Ethanol, 2-amino-,1-(hydrogen sulfate) supplier

Name
2-AMINOETHYL HYDROGEN SULFATE
EINECS 213-135-7
CAS No. 926-39-6
Article Data29
CAS DataBase
Density 1.566 g/cm³
Solubility almost transparency
Melting Point 277 °C (dec.)(lit.)
Formula C₂H₇NO₄S
Boiling Point 296.49℃[at 101 325 Pa]
Molecular Weight 141.148
Flash Point
Transport Information
Appearance white to slightly beige fine crystalline powder
Safety 26-36
Risk Codes 22-36/37/38
Molecular Structure
Hazard Symbols Xn
Synonyms Ethanol,2-amino-, hydrogen sulfate (7CI);Ethanol, 2-amino-, hydrogen sulfate (ester)(8CI,9CI);Ethanol, 2-amino-, sulfate (6CI);2-Aminoethanol hydrogen sulfate(ester);2-Aminoethyl hydrogen sulfate;2-Aminoethyl sulfate;2-Aminoethylsulfuric acid;Ethanolamine O-sulfate;Ethanolamine sulfate;Mono(2-aminoethyl)sulfate;NSC 204188;NSC 3532;WAS-34;
PSA 98.00000
LogP 0.54560

Synthetic route

: 141-43-5
ethanolamine

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

Conditions

Conditions	Yield
With sulfuric acid; tetrabutylammomium bromide In toluene at 40℃; for 1.5h;	99%
With sulfuric acid In water at -5 - 5℃; for 0.5h;	90.72%
With sulfuric acid	89%

: 151-56-4
ethyleneimine

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

Conditions

Conditions	Yield
With sulfuric acid

: 497-25-6
dimethylenecyclourethane

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

Conditions

Conditions	Yield
With sulfuric acid

: 2576-47-8
2-bromoethylamine hydrobromide

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

Conditions

Conditions	Yield
With silver sulfate

: 141-43-5
ethanolamine

: 77-78-1
dimethyl sulfate

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

: 861555-02-4
(2-amino-ethyl)-nitroso-amidosulfuric acid

: 108-95-2
phenol

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

: 1072-53-3
ethyleneglycol sulfate

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

Conditions

Conditions	Yield
With ammonia In dichloromethane

: 151-56-4
ethyleneimine

: 7664-93-9
sulfuric acid

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

: 7664-93-9
sulfuric acid

: 7446-11-9
sulfur trioxide

: 141-43-5
ethanolamine

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

...Expand

N-nitroso-ethylenediamine-N-sulfonic acid: N-nitroso-ethylenediamine-N-sulfonic acid

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

Conditions

Conditions	Yield
With phenol

: 7803-63-6
ammonium bisulfate

: 141-43-5
ethanolamine

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

Conditions

Conditions	Yield
With ammonium sulfate

: 109-58-0
N-β-aminoethylcarbamic acid

: 142-27-8
carbamic acid-(2-amino-ethyl ester)

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

: 7664-93-9
sulfuric acid

: 141-43-5
ethanolamine

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

Conditions

Conditions	Yield
at 270 - 280℃; Product distribution / selectivity;

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

: 90-02-8
salicylaldehyde

: 110925-66-1
C9H10NO5S(1-)*Na(1+)

Conditions

Conditions	Yield
With sodium hydroxide In ethanol	95%

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

: 121-33-5
vanillin

: 110925-69-4
C10H12NO6S(1-)*Na(1+)

Conditions

Conditions	Yield
With sodium hydroxide In ethanol	94%

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

: 107-35-7
Tau

Conditions

Conditions	Yield
Stage #1: sulfuric acid mono-(2-amino-ethyl ester) With ammonium sulfite monohydrate at 120℃; for 18h; Autoclave; Stage #2: With ammonium sulfite monohydrate; sodium hydroxide In water pH=7.2; Temperature;	88.1%
With water; sodium sulfite

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

: 708-06-5
2-hydroxynaphthalene-1-carbaldehyde

: 110925-71-8
C13H12NO5S(1-)*Na(1+)

Conditions

Conditions	Yield
With sodium hydroxide In ethanol	88%

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

: 98769-72-3, 98819-72-8
(-)-(2S,3S)-3-(2-ethoxyphenoxy)-3-phenylpropene-1,2-epoxide

A: 1250978-71-2
2-{[(2S,3S)-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropyl]amino}ethyl hydrogen sulfate

B: 1250978-88-1
C36H43NO10S

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In ethanol; toluene	A 86% B n/a
With 1,8-diazabicyclo[5.4.0]undec-7-ene In methanol at 70℃;	A 92 %Chromat. B 6 %Chromat.

...Expand

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

: 141-43-5
ethanolamine

: 107-35-7
Tau

Conditions

Conditions	Yield
With ammonium sulfate; sulfuric acid; ammonium sulfite monohydrate In water at 110℃; for 24h; pH=6.2 - 7.2; Autoclave;	85%

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

: 123-11-5
4-methoxy-benzaldehyde

: 110925-68-3
C10H12NO5S(1-)*Na(1+)

Conditions

Conditions	Yield
With sodium hydroxide In ethanol	83%

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 110925-70-7
C11H14NO6S(1-)*Na(1+)

Conditions

Conditions	Yield
With sodium hydroxide In ethanol	80.2%

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

: 98769-72-3, 98819-72-8
(-)-(2S,3S)-3-(2-ethoxyphenoxy)-3-phenylpropene-1,2-epoxide

: 1250978-71-2
2-{[(2S,3S)-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropyl]amino}ethyl hydrogen sulfate

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene Inert atmosphere;	78%
Stage #1: sulfuric acid mono-(2-amino-ethyl ester) With 1,8-diazabicyclo[5.4.0]undec-7-ene In ethanol; toluene at 65℃; for 1h; Stage #2: (-)-(2S,3S)-3-(2-ethoxyphenoxy)-3-phenylpropene-1,2-epoxide In ethanol; toluene at 65 - 70℃; for 3h;	74%
Stage #1: sulfuric acid mono-(2-amino-ethyl ester) With 1,8-diazabicyclo[5.4.0]undec-7-ene In ethanol; toluene at 65℃; for 1h; Stage #2: (-)-(2S,3S)-3-(2-ethoxyphenoxy)-3-phenylpropene-1,2-epoxide In ethanol; toluene at 70℃; for 3h;	1.1 kg
With 1,8-diazabicyclo[5.4.0]undec-7-ene In ethanol; toluene at 65 - 70℃;

: 1452772-76-7
(2R,3S)-3-(2-ethoxyphenoxy)-3-phenylpropene-1,2-epoxide

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

: 1356958-71-8
{[(2R,3S)-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropyl]amino}ethyl hydrogen sulfate

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene Inert atmosphere;	78%

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

: 30190-85-3
1-(inden-7-yloxy)-2,3-epoxypropane

: 65043-22-3
2-(7-indenyloxymethyl)-morpholine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; sodium hydroxide In methanol 1.) 55 deg C, 16 h; 2.) iso-PrOH, acetone, 0-5 deg C, 15 min.;	73%

: 75-15-0
carbon disulfide

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

: 134469-06-0
thiazolidine-2-thione

Conditions

Conditions	Yield
With potassium hydroxide	68%
With sodium hydroxide In ethanol at 40℃; for 3h;	68%
With sodium hydroxide In ethanol; water for 0.666667h; Heating;
With potassium hydroxide

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

: 721453-42-5
(+/-)-2-(2-ethoxy-4-iodophenyloxymethyl)oxirane

: 721453-43-6
(+/-)-2-[(2-ethoxy-4-iodophenoxy)methyl]morpholine

Conditions

Conditions	Yield
With sodium hydroxide In isopropyl alcohol for 8h; Heating;	67%

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

: 721453-55-0
(+/-)-2-(5-chloro-2-methoxyphenyloxymethyl)oxirane

: 721453-56-1
(+/-)-2-[(5-chloro-2-methoxyphenoxy)methyl]morpholine

Conditions

Conditions	Yield
With sodium hydroxide In isopropyl alcohol Heating;	65%

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

: 551-06-4
1-isothiocyanatonaphthalene

: 35160-17-9
(4,5-dihydro-thiazol-2-yl)-naphthalen-1-yl-amine

Conditions

Conditions	Yield
With sodium hydroxide; ethanol	64%

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

: 14618-80-5
(R)-benzyl glycidol

: 135065-70-2
(2R)-2-[(benzyloxy)methyl]morpholine

Conditions

Conditions	Yield
With sodium hydroxide In water at 50 - 55℃; for 21h;	62%
With sodium hydroxide In methanol; water at 50℃;	49%
With sodium hydroxide In methanol; water at 50℃;	49%

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

: 151-56-4
ethyleneimine

Conditions

Conditions	Yield
With sodium hydroxide In water Heating;	60%
With sodium hydroxide
With potassium hydroxide

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

: 5392-12-1
2-methoxy-1-naphthaldehyde

: 110925-72-9
2-Methoxy-1-naphthalideneiminoethyl hydrogen sulfate sodium salt

Conditions

Conditions	Yield
With sodium hydroxide In ethanol	58.1%

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

: 300-84-5
hypotaurine

Conditions

Conditions	Yield
With sodium dithionite; water at 90 - 100℃; for 12h; Temperature; Inert atmosphere;	53.87%

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

: (R)-1-chloro-3-(3,5-dichlorophenyl)propan-2-ol

: (R)-2-(3,5-dichlorobenzyl)morpholine

Conditions

Conditions	Yield
With sodium hydroxide In methanol; water; toluene at 40 - 65℃; for 21.5h;	53%

: (R)-1-chloro-3-(2-methoxyphenyl)-2-propanol

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

: (R)-2-(2-methoxybenzyl)morpholine

Conditions

Conditions	Yield
With sodium hydroxide In methanol; water; toluene at 20 - 65℃; for 19.0833h;	50%

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

: 2930-05-4, 14618-80-5, 89616-40-0, 16495-13-9
(S)-benzyl glycidyl ether

: 167357-55-3
(+)-2(S)-(phenylmethyloxymethyl)morpholine

Conditions

Conditions	Yield
With sodium hydroxide In methanol; water at 50 - 55℃; for 17h;	49%
With sodium hydroxide In methanol; water at 50 - 55℃; for 17h;	49%
Stage #1: sulfuric acid mono-(2-amino-ethyl ester); (S)-benzyl glycidyl ether With sodium hydroxide In methanol; water at 40℃; for 4h; Stage #2: With sodium hydroxide In methanol; water; toluene at 65℃; for 12h;

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

: 1598383-26-6
(R)-1-chloro-3-thiophen-2-yl-propan-2-ol

: 1598383-27-7
(R)-2-(thiophen-2-ylmethyl)-morpholine

Conditions

Conditions	Yield
Stage #1: (R)-1-chloro-3-thiophen-2-yl-propan-2-ol With sodium hydroxide In methanol; water at 20℃; for 0.0833333h; Stage #2: sulfuric acid mono-(2-amino-ethyl ester) In methanol; water at 45℃; for 2.75h; Stage #3: With sodium hydroxide In methanol; water; toluene at 65℃;	48%

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

: 622-59-3
1-isothiocyanato-4-methylbenzene

: 102942-89-2
N-(4-Methylphenyl)-4,5-dihydro-2-thiazolamine

Conditions

Conditions	Yield
With sodium hydroxide; ethanol	44%

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

: 95-01-2
2,4-Dihydroxybenzaldehyde

: 110925-67-2
C9H10NO6S(1-)*Na(1+)

Conditions

Conditions	Yield
With sodium hydroxide In ethanol	44%

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

: 110-16-7
maleic acid

: 2-(benzyloxymethyl)morpholine hydrogen maleate

Conditions

Conditions	Yield
With sulfuric acid In methanol; water; toluene	40%

: 5296-35-5
1,2-Anhydro-3-O-(o-ethoxyphenyl)-glycerol

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

: 46817-91-8
viloxazine

Conditions

Conditions	Yield
With potassium hydroxide In methanol; water Product distribution / selectivity;	39.8%

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

: 137935-40-1
(2-nitro-4-trifluoromethylphenyl)isothiocyanate

: 137935-32-1
(4,5-Dihydro-thiazol-2-yl)-(2-nitro-4-trifluoromethyl-phenyl)-amine

Conditions

Conditions	Yield
With sodium hydroxide; ethanol	39%

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

: 100-52-7
benzaldehyde

: 110925-65-0
C9H10NO4S(1-)*Na(1+)

Conditions

Conditions	Yield
With sodium hydroxide In ethanol at 60 - 70℃; for 2h;	38.2%

Ethanol, 2-amino-,1-(hydrogen sulfate) Specification

The Ethanol, 2-amino-,1-(hydrogen sulfate), with the CAS registry number 926-39-6 and EINECS registry number 213-135-7, has the systematic name and IUPAC name of 2-aminoethyl hydrogen sulfate. It is a kind of white to slightly beige fine crystalline powder, and shoud be stored in the dry and cool environment. And the molecular formula of the chemical is C₂H₇NO₄S.

The characteristics of Ethanol, 2-amino-,1-(hydrogen sulfate) are as followings: (1)ACD/LogP: -1.02; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -3.53; (4)ACD/LogD (pH 7.4): -3.67; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 5; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 4; (12)Polar Surface Area: 64.22 Å²; (13)Index of Refraction: 1.511; (14)Molar Refractivity: 27.01 cm³; (15)Molar Volume: 90.1 cm³; (16)Polarizability: 10.71×10^-24cm³; (17)Surface Tension: 69.6 dyne/cm; (18)Density: 1.566 g/cm³.

Preparation of Ethanol, 2-amino-,1-(hydrogen sulfate): This chemical can be prepared by 2-amino-ethanol. The reaction will need reagent conc. sulfuric acid, and temperature 160°C.

Uses of Ethanol, 2-amino-,1-(hydrogen sulfate): It can react with 2-Trifluormethyl-phenyl-isothiocyanat to produce (4,5-dihydro-thiazol-2-yl)-(2-trifluoromethyl-phenyl)-amine. This reaction will need reagent NaOH and 50% EtOH. And the yield is about 20%.

You should be cautious while dealing with this chemical. It irritates to eyes, respiratory system and skin, and it is also harmful if swallowed. Therefore, you had better take the following instructions: Wear suitable protective clothing, and if in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

Addtionally, the following datas could be converted into the molecular structure:
(1)SMILES: O=S(=O)(O)OCCN
(2)InChI: InChI=1/C2H7NO4S/c3-1-2-7-8(4,5)6/h1-3H2,(H,4,5,6)
(3)InChIKey: WSYUEVRAMDSJKL-UHFFFAOYAA

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	> 2gm/kg (2000mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Neuropharmacology. Vol. 21, Pg. 803, 1982.
mouse	LD50	oral	1100mg/kg (1100mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 33(10), Pg. 57, 1989.

Product Name

2-AMINOETHYL HYDROGEN SULFATE

Synthetic route

Ethanol, 2-amino-,1-(hydrogen sulfate) Specification

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