ethanolamine
Conditions | Yield |
---|---|
With sodium hydrogen sulfate; silica gel In methanol; dichloromethane at 20℃; for 3.5h; | 95% |
benzylamine
5-(2-hydroxyethyl)hexahydro-1,3,5-dithiazine
A
1,3,5-Tribenzyl-1,3,5-triazacyclohexane
B
ethanolamine
Conditions | Yield |
---|---|
at 20℃; for 24h; | A 95% B n/a |
Conditions | Yield |
---|---|
With hydrogen In para-xylene; isopropyl alcohol at 25℃; under 760.051 Torr; for 3h; | A 5% B 95% |
Conditions | Yield |
---|---|
With sulfuric acid; hydrogen In water at 79.84℃; under 60006 Torr; | 92.3% |
With zinc borohydride In tetrahydrofuran for 7h; Heating; | 70% |
With sodium tetrahydroborate; iodine In tetrahydrofuran |
Conditions | Yield |
---|---|
With caesium carbonate In methanol at 60℃; for 8h; | 92% |
N-tritylethanolamine
ethanolamine
Conditions | Yield |
---|---|
With sodium hydrogen sulfate; silica gel In methanol; dichloromethane at 20℃; for 3.5h; | 90% |
Conditions | Yield |
---|---|
With ammonium formate; palladium on activated charcoal In methanol for 0.166667h; Heating; | 86% |
With 9,10-Dicyanoanthracene In water; acetonitrile Irradiation; | 80% |
With di-isopropyl azodicarboxylate In tetrahydrofuran at 20℃; for 336h; |
glycolaldehyde dimer
ethanolamine
Conditions | Yield |
---|---|
With ammonium hydroxide; Ni6AlO(z); hydrogen at 80℃; under 3750.38 Torr; for 3h; Autoclave; | 85% |
With ammonia; hydrogen; cobalt/manganese/sodium/phosphorous reduced catalyst In water at 100℃; under 75007.5 Torr; for 8h; Product distribution / selectivity; Autoclave; |
2-(3-nitrophenoxy)ethanamine
B
meta-nitrophenol
C
N-(2-hydroxyethyl)-3-nitroaniline
D
ethanolamine
Conditions | Yield |
---|---|
With deuteriated sodium hydroxide In water-d2 at 20℃; for 0.833333h; Smiles rearrangement; UV-irradiation; | A 15% B n/a C 73% D n/a |
Conditions | Yield |
---|---|
With sodium tetrahydroborate In diethylene glycol dimethyl ether at 76 - 78℃; for 3h; | 70% |
With lithium aluminium tetrahydride In tetrahydrofuran for 5h; |
Conditions | Yield |
---|---|
With hydrogen; iridium In cyclohexane; glycerol at 180℃; under 15001.5 Torr; for 3.08h; Reagent/catalyst; Temperature; Solvent; Pressure; Autoclave; | 61% |
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran for 2h; Heating; | 55% |
oxirane
ammonia
A
triethanolamine
B
ethanolamine
C
2,2'-iminobis[ethanol]
Conditions | Yield |
---|---|
water at 48.84 - 76.84℃; under 12751.3 Torr; for 0.25h; | A 7.7% B 52.1% C 40.2% |
ethylene glycol
A
piperazine
B
ethanolamine
C
2-(2-Aminoethylamino)ethanol
D
ethylenediamine
E
1,5-diamino-3-azapentane
F
2,2'-iminobis[ethanol]
Conditions | Yield |
---|---|
Stage #1: ethylene glycol With ammonia; hydrogen at 150℃; under 150015 Torr; Stage #2: copper oxide; graphite; molybdenum oxide; nickel oxide; zirconium dioxide; mixture of at 170℃; under 150015 Torr; | A 6.8% B 29% C 5.7% D 49.5% E 3.9% F 1.7% |
With ammonia; hydrogen at 170 - 180℃; under 150015 Torr; Conversion of starting material; | |
With ammonia; water; hydrogen at 180℃; under 150015 Torr; Conversion of starting material; | |
With ammonia; hydrogen at 150 - 170℃; under 150015 Torr; Conversion of starting material; | |
With ammonia; hydrogen at 200℃; under 150015 Torr; Conversion of starting material; |
2-(Ethylamino)ethanol
A
formaldehyd
B
ethylamine
C
ethanolamine
D
acetaldehyde
Conditions | Yield |
---|---|
With water at 25℃; anodic oxidation, pH 10, carbonate buffer; Further byproducts given; | A 14% B 43% C 45% D 44% |
2-(Ethylamino)ethanol
A
formaldehyd
B
ethylamine
C
ethanolamine
D
acetaldehyde
E
Glycolaldehyde
Conditions | Yield |
---|---|
With water at 25℃; Product distribution; Mechanism; anodic oxidation, carbonate buffer, pH 10; effect of substituents investigated with different types of β-alkanolamines; | A 14% B 43% C 45% D 44% E n/a |
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran for 2h; Heating; | 44% |
2-aminoethyl vinyl ether
A
2-methyl-2,3,4,5-tetrahydroisoxazole
B
N-Ethylideneethanolamine Vinyl Ether
C
ethanolamine
Conditions | Yield |
---|---|
With palladium dichloride In benzene Heating; | A 21% B 33% C n/a |
mercury(II) diacetate In hexane at 60℃; for 4h; | A 20% B 28.3 g C 26.1 g |
phenyllithium
N-(1,2,5-trimethylpiperidinylidene-4-)-β-hydroxyethylamine
A
1,2,5-trimethyl-4-piperidone
B
ethanolamine
C
1,2,5-trimethyl-4-phenyl-4-N-(β-hydroxyethyl)aminopiperidine
Conditions | Yield |
---|---|
In diethyl ether | A n/a B n/a C 11% |
Conditions | Yield |
---|---|
Stage #1: benzaldehyde; ethanolamine In methanol at 20℃; for 0.25h; Stage #2: With methanol; sodium tetrahydroborate at 0 - 20℃; | 100% |
With copper chromium spinel oxide; hydrogen; barium(II) oxide at 130℃; under 37503 Torr; for 1h; | 97.8% |
Stage #1: benzaldehyde; ethanolamine With magnesium sulfate In methanol at 20℃; for 18h; Stage #2: With sodium tetrahydroborate In methanol at 0 - 20℃; for 1h; | 95% |
formaldehyd
ethanolamine
1,3,5-tris(2-hydroxyethyl)-1,3,5-triazacyclohexane
Conditions | Yield |
---|---|
In methanol at 20℃; for 16h; | 100% |
In methanol for 48h; | 86% |
With water | |
In ethanol Cyclization; | |
at 50 - 80℃; for 1h; | 92 g |
Conditions | Yield |
---|---|
Stage #1: formaldehyd; ethanolamine In water at 10℃; for 24h; Stage #2: With sulfur dioxide In water at 20℃; pH=<= 1.0; | 100% |
With water und anschliessende Saettigung mit SO2; |
Conditions | Yield |
---|---|
With 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine In acetonitrile at 20℃; for 15h; Schlenk technique; Inert atmosphere; | 100% |
at 100 - 120℃; |
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; for 1h; | 100% |
In benzene for 0.5h; Ambient temperature; | 95% |
With triethylamine In dichloromethane at 20℃; for 6h; Large scale; | 95.3% |
ethanolamine
4-methyl-2-pentanone
(2-aminoethanol)methyl isobutyl ketimine
Conditions | Yield |
---|---|
at 76 - 99℃; under 252.025 Torr; for 2h; Dean-Stark; | 100% |
In cyclohexane at 90.7 - 105.9℃; for 2h; Dean-Stark; Reflux; | 99% |
In cyclohexane at 90.7 - 105.9℃; for 2h; Dean-Stark; | 99% |
ethanolamine
p-toluenesulfonyl chloride
N-(2-hydroxy-ethyl)-4-methyl-benzenesulfonamide
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; for 18h; Inert atmosphere; | 100% |
With triethylamine In dichloromethane at 0 - 20℃; for 24h; | 99% |
With pyridine at 5 - 20℃; | 96% |
Conditions | Yield |
---|---|
Stage #1: ethanolamine With sodium ethanolate at 20℃; for 0.5h; Stage #2: formic acid ethyl ester In ethanol for 1h; Heating; Further stages.; | 100% |
at 10 - 20℃; for 12h; | 100% |
99% |
ethyl trifluoroacetate,
ethanolamine
N-(2-hydroxyethyl)-2,2,2-trifluoroacetamide
Conditions | Yield |
---|---|
In acetonitrile | 100% |
at 20℃; for 2h; | 100% |
With triethylamine In methanol; water | 95% |
ethanolamine
phosphonic acid diethyl ester
(2-hydroxy-ethyl)-phosphoramidic acid diethyl ester
Conditions | Yield |
---|---|
With potassium carbonate; potassium hydrogencarbonate; tetrabutylammomium bromide In tetrachloromethane; dichloromethane at 15 - 20℃; for 2h; | 100% |
With tetrachloromethane; triethylamine In tetrahydrofuran at 0 - 20℃; Atherton-Tood reaction; Inert atmosphere; | 100% |
With triethylamine In tetrachloromethane; benzene |
ethanolamine
1-phenylbutan-1,3-dione
(Z)-3-(2-hydroxyethylamino)-1-phenylbut-2-en-1-one
Conditions | Yield |
---|---|
at 130℃; for 0.0833333h; microwave irradiation; | 100% |
With potassium dihydrogenphosphate at 50℃; for 0.5h; neat (no solvent); | 96% |
With β‐cyclodextrin In water at 20℃; for 0.5h; chemospecific reaction; | 88% |
2-[2-(vinyloxy)ethoxymethyl]oxirane
ethanolamine
Conditions | Yield |
---|---|
at 60℃; for 4h; | 100% |
trimethylsilyl isocyanate
ethanolamine
<2-(trimethylsilyloxy)ethyl>urea
Conditions | Yield |
---|---|
at 20 - 80℃; for 2h; | 100% |
2,2,4-trichlorobutanal
ethanolamine
7,7-Dichloro-hexahydro-pyrrolo[2,1-b]oxazole
Conditions | Yield |
---|---|
100% |
di-tert-butyl dicarbonate
ethanolamine
2-(N-tert-butoxycarbonylamino)ethanol
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 5h; | 100% |
aminosulfonic acid at 25 - 28℃; for 0.0833333h; | 100% |
With sodium hydroxide In 1,4-dioxane; water at 0℃; for 2h; | 100% |
5-(dimethylamino)naphth-1-ylsulfonyl chloride
ethanolamine
5-dimethylamino-N-(2-hydroxyethyl)naphthalene-1-sulfonamide
Conditions | Yield |
---|---|
With pyridine for 17h; sulfonylation; | 100% |
With triethylamine In dichloromethane | 98% |
In water at 80℃; | 96% |
Conditions | Yield |
---|---|
In tetrahydrofuran at -5 - 19℃; for 2h; | 100% |
o-formylbenzonitrile
ethanolamine
3-(2-Hydroxy-ethylamino)-2,3-dihydro-isoindol-1-one
Conditions | Yield |
---|---|
at 40℃; for 1h; | 100% |
2-(vinyloxy)ethyl isothiocyanate
ethanolamine
1-(2-Hydroxy-ethyl)-3-(2-vinyloxy-ethyl)-thiourea
Conditions | Yield |
---|---|
100% |
Conditions | Yield |
---|---|
In water at 65℃; for 14h; | 100% |
ethanolamine
2,3:5,6-di-O-cyclohexylidene-D-manno-furanose
Conditions | Yield |
---|---|
With acetic acid In benzene for 1h; Heating; | 100% |
ethanolamine
Conditions | Yield |
---|---|
In diethyl ether; water at 20℃; for 12h; | 100% |
ethanolamine
4-(ethoxycarbonylamino)-thiophene-3-carboxaldehyde
(4-{[(E)-2-Hydroxy-ethylimino]-methyl}-thiophen-3-yl)-carbamic acid ethyl ester
Conditions | Yield |
---|---|
In ethanol for 0.333333h; Heating; | 100% |
ethanolamine
(2-Ethyl-4-formyl-thiophen-3-yl)-carbamic acid ethyl ester
(2-Ethyl-4-{[(E)-2-hydroxy-ethylimino]-methyl}-thiophen-3-yl)-carbamic acid ethyl ester
Conditions | Yield |
---|---|
In ethanol for 0.333333h; Heating; | 100% |
ethanolamine
(4-Formyl-2,5-dimethyl-thiophen-3-yl)-carbamic acid ethyl ester
(4-{[(E)-2-Hydroxy-ethylimino]-methyl}-2,5-dimethyl-thiophen-3-yl)-carbamic acid ethyl ester
Conditions | Yield |
---|---|
In ethanol for 0.333333h; Heating; | 100% |
ethanolamine
1-Methyl-6-methylsulfanyl-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydro-pyrimidine-5-carbonitrile
6-(2-Hydroxy-ethylamino)-1-methyl-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydro-pyrimidine-5-carbonitrile
Conditions | Yield |
---|---|
In acetonitrile for 0.0833333h; Ambient temperature; | 100% |
ethanolamine
5-Methoxy-4-phenyl-5,6-dihydro-4H-[1,3,4]thiadiazine
Conditions | Yield |
---|---|
Ambient temperature; | 100% |
ethanolamine
tetramethyl-2,2,3,3-dimethylamino-5-ethoxy-7 carboethoxy-9 trioxa-1,4,6 diaza-8,9 phospha(V)-5 spiro(4,4)noneme-7,8
Conditions | Yield |
---|---|
In diethyl ether for 1h; Ambient temperature; | 100% |
ethanolamine
2-Fluorobenzoyl chloride
2-fluoro-N-(2-hydroxyethyl)benzamide
Conditions | Yield |
---|---|
With sodium hydroxide In dichloromethane; water for 1h; Ambient temperature; | 100% |
With triethylamine In dichloromethane at 25℃; for 2h; | 95% |
With potassium carbonate In methanol at 0 - 20℃; for 15h; Inert atmosphere; |
ethanolamine
2-fluoro-2,2-dinitroethylchloroformate, pentafluorosulfanylimine
N-(2-hydroxyethyl)-2-fluoro-2,2-dinitroethyl carbamate, pentafluorosulfanylimine
Conditions | Yield |
---|---|
In dichloromethane at 0℃; for 1.5h; | 100% |
The molecular structure of Ethanolamine (CAS No. 141-43-5):
IUPAC Name: 2-Aminoethanol
Molecular Formula: C2H7NO
Molecular Weight: 61.10g/mol
EINECS: 205-483-3
Melting Point: 10.3 ºC
Freely Rotating Bonds: 3
Polar Surface Area: 46.25 Å2
Index of Refraction: 1.435
Molar Refractivity: 16.38 cm3
Molar Volume: 62.7 cm3
Polarizability: 6.49 ×10-24cm3
Surface Tension: 39.7 dyne/cm
Density: 0.973 g/cm3
Flash Point: 93.3 °C
Melting point: 10-11 °C(lit.)
Enthalpy of Vaporization: 47.43 kJ/mol
Boiling Point: 170.9 °C at 760 mmHg
Vapour Pressure: 0.458 mmHg at 25°C
EINECS: 205-483-3
Product Categories: Pharmaceutical Intermediates; Thanolamine Series; omega-Aminoalkanols; omega-Functional Alkanols, Carboxylic Acids, Amines & Halides
Ethanolamine (CAS NO.141-43-5) is produced by reacting ethylene oxide with aqueous ammonia; the reaction also produces diethanolamine and triethanolamine.
1. | ratLD50:1500mg/kg | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 23(9), Pg. 55, 1979. | ||
2. | ratLD50:1720mg/kg | Toxicology and Applied Pharmacology. Vol. 42, Pg. 417, 1977. | ||
3. | rabbitLD50:1mL/kg | Union Carbide Data Sheet. Vol. 1/13/1972, | ||
4. | mouseLD50:700mg/kg | Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 4, Pg. 81, 1962. |
Hazard Codes: T C
Risk Statements: 20/21/22-34-39/23/24/25-23/24/25-10
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
R34: Causes burns.
R23/24/25: Toxic by inhalation, in contact with skin and if swallowed.
R10: Flammable.
Safety Statements: 26-36/37/39-45
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 2924 3/PG 3
WGK Germany: 1
RTECS: KJ5775000
F: 8-10-23
HazardClass: 8
PackingGroup: III
Ethanolamine , with CAS number of 141-43-5, can be called 1-Amino-2-hydroxyethane ; 2-Amino-1-ethanol ; 2-Aminoaethanol ; EPA Pesticide Chemical Code 011601 ; Glycinol (monoethanolamine) ; Monoaethanolamin ; Monoethanolamine . It can be used in organic synthesis.The extinguishing agent of Ethanolamine (CAS NO.141-43-5) are dry powder, foam, sand, carbon dioxide, water mist.
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