Conditions | Yield |
---|---|
With magneticnanosolidsuperacid In cyclohexane; water at 83 - 85℃; Reagent/catalyst; Temperature; | 97% |
Stage #1: fenofibric acid; isopropyl alcohol With thionyl chloride for 7h; Reflux; Stage #2: With potassium carbonate In water at 60 - 65℃; | 96.6% |
With macroporous strong acid cation exchange resin D001 In water; toluene at 110℃; | 92.4% |
Conditions | Yield |
---|---|
Stage #1: fenofibric acid With potassium carbonate In Isopropyl acetate; dimethyl sulfoxide at 20 - 90℃; for 0.75h; Industry scale; Inert atmosphere; Stage #2: isopropyl bromide In Isopropyl acetate; dimethyl sulfoxide at 80 - 95℃; for 5.83333h; | 94.9% |
fenofibrate
Conditions | Yield |
---|---|
With tert.-butylhydroperoxide; copper (II) carbonate hydroxide; TPGS-750-M In water at 20℃; Green chemistry; | 91% |
isopropyl 2-bromo-2‑methylpropanoate
4-chloro-4'-hydroxybenzophenone
fenofibrate
Conditions | Yield |
---|---|
With potassium hydrogencarbonate In isopropyl alcohol for 48h; Reflux; | 90% |
Stage #1: 4-chloro-4'-hydroxybenzophenone With sodium hydroxide In butanone for 1h; Reflux; Stage #2: isopropyl 2-bromo-2‑methylpropanoate In butanone for 8h; Reflux; | 90% |
Stage #1: 4-chloro-4'-hydroxybenzophenone With potassium hydrogencarbonate In isopropyl alcohol at 25℃; for 0.166667h; Stage #2: isopropyl 2-bromo-2‑methylpropanoate In isopropyl alcohol at 90℃; for 48h; | 90% |
isopropyl 2-(4-iodophenoxy)-2-methylpropanoate
4-Chlorophenylboronic acid
molybdenum hexacarbonyl
fenofibrate
Conditions | Yield |
---|---|
With potassium phosphate; palladium(II) trifluoroacetate In water; acetonitrile at 50℃; for 6h; Suzuki Coupling; Inert atmosphere; Sealed tube; | 90% |
carbon monoxide
isopropyl 2-(4-iodophenoxy)-2-methylpropanoate
4-Chlorophenylboronic acid
fenofibrate
Conditions | Yield |
---|---|
With potassium carbonate; palladium dichloride at 80℃; for 16h; Sealed tube; | 89% |
With tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; triethylamine In 1,4-dioxane at 80℃; for 20h; Inert atmosphere; Sealed tube; Cooling with ice; | 80% |
With potassium carbonate; triphenylphosphine; palladium dichloride at 80℃; for 18h; | 65 %Chromat. |
isopropyl 2-(4-iodophenoxy)-2-methylpropanoate
4-Chlorophenylboronic acid
9-methyl-9H-fluorene-9-carbonyl chloride
fenofibrate
Conditions | Yield |
---|---|
Stage #1: 9-methyl-9H-fluorene-9-carbonyl chloride With N-ethyl-N,N-diisopropylamine; bis(dibenzylideneacetone)-palladium(0); tri tert-butylphosphoniumtetrafluoroborate at 80℃; Stage #2: isopropyl 2-(4-iodophenoxy)-2-methylpropanoate; 4-Chlorophenylboronic acid With potassium carbonate; palladium dichloride at 80℃; | 84% |
isopropyl 2-(4-bromophenoxy)-2-methylpropanoate
2-(4-chloro-phenyl)-[1,3,6,2]dioxazaborocane
9-methyl-9H-fluorene-9-carbonyl chloride
fenofibrate
Conditions | Yield |
---|---|
With palladium(II) acetylacetonate; N-ethyl-N,N-diisopropylamine; bis(dibenzylideneacetone)-palladium(0); tri tert-butylphosphoniumtetrafluoroborate; di(1-adamantyl)-N-butylphosphine hydroiodide In water; N,N-dimethyl-formamide; toluene at 80℃; for 16h; Suzuki-Miyaura Coupling; Inert atmosphere; Glovebox; | 83% |
Conditions | Yield |
---|---|
With 2,6-di-tert-butyl-pyridine; bis(η3-allyl-μ-chloropalladium(II)); silver(I) triflimide In 1,2-dichloro-ethane at 65℃; under 22801.5 Torr; for 24h; Reagent/catalyst; Inert atmosphere; Sealed tube; Glovebox; Schlenk technique; | 83% |
4-((4-chlorophenyl)(hydroxy)methyl)phenol
fenofibrate
Conditions | Yield |
---|---|
With oxygen; Langlois reagent In acetonitrile at 25℃; under 760.051 Torr; for 12h; Irradiation; | 83% |
carbon monoxide
isopropyl 2-(4-iodophenoxy)-2-methylpropanoate
fenofibrate
Conditions | Yield |
---|---|
With sodium carbonate; Trimethylacetic acid at 120℃; under 760.051 Torr; for 12h; Suzuki Coupling; | 80% |
Conditions | Yield |
---|---|
With palladium diacetate; N-picolinoylcyclohexylamine; potassium hydrogencarbonate In tert-Amyl alcohol at 150℃; for 24h; | 75% |
fenofibrate
Conditions | Yield |
---|---|
With 1-hydroxy-pyrrolidine-2,5-dione; graphitic carbon nitride; oxygen In acetonitrile at 20℃; Inert atmosphere; Irradiation; | 75% |
With 1,1'-bis-(diphenylphosphino)ferrocene; oxygen; 2,5-Dimercapto-1,3,4-thiadiazole In acetonitrile at 20 - 80℃; under 760.051 Torr; for 15h; Schlenk technique; | 67% |
1-Chloro-4-iodobenzene
fenofibrate
Conditions | Yield |
---|---|
With (1,2-dimethoxyethane)dichloronickel(II); [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate; lithium carbonate; 4,4'-di-tert-butyl-2,2'-bipyridine In water; N,N-dimethyl-formamide for 96h; Inert atmosphere; Irradiation; | 71% |
With [nickel(II)dichloride(dimethoxyethane)]; Ir[dF(CF3)ppy]2(dtbbpy)PF6; lithium carbonate; 4,4'-di-tert-butyl-2,2'-bipyridine In water; N,N-dimethyl-formamide for 96h; Inert atmosphere; Sealed tube; Microwave irradiation; | 71% |
3-oxobenzo[d]isothiazole-2(3H)-carbaldehyde 1,1-dioxide
isopropyl 2-(4-iodophenoxy)-2-methylpropanoate
4-Chlorophenylboronic acid
fenofibrate
Conditions | Yield |
---|---|
With potassium phosphate; sodium carbonate; N-ethyl-N,N-diisopropylamine at 120℃; for 48h; | 69% |
S-(2-pyridinyl) 4-chlorobenzenecarbothioate
fenofibrate
Conditions | Yield |
---|---|
With 4,4'-di-tert-butyl-2,2'-bipyridine; cobalt(II) chloride In tetrahydrofuran at 25℃; for 4h; | 65% |
Conditions | Yield |
---|---|
With nickel(II) bromide dimethoxyethane; potassium phosphate; Ir(dFCF3(ppy))2(4,4’-ditert-butyl-2,2’-bipyrididyl)PF6; caesium carbonate; triphenylphosphine; 4,4'-di-tert-butyl-2,2'-bipyridine In N,N-dimethyl-formamide; acetonitrile at 25℃; for 20h; Inert atmosphere; | 65% |
isopropyl 2-(4-iodophenoxy)-2-methylpropanoate
para-Chlorobenzyl alcohol
fenofibrate
Conditions | Yield |
---|---|
With tert.-butylhydroperoxide; palladium diacetate; silver(l) oxide In water at 120℃; for 24h; Schlenk technique; Inert atmosphere; | 52% |
(p-chlorophenyl)triethoxysilane
fenofibrate
Conditions | Yield |
---|---|
With lithium acetate; palladium diacetate; triethylamine tris(hydrogen fluoride); tricyclohexylphosphine In 1,4-dioxane; water at 90℃; for 6h; Hiyama Coupling; | 45% |
chloroform
4-chloro-4'-hydroxybenzophenone
isopropyl alcohol
acetone
fenofibrate
Conditions | Yield |
---|---|
(i) KOH, (ii) /BRN= 1731042/, (iii) /BRN= 635639/, H2SO4, benzene; Multistep reaction; |
4-chloro-4'-hydroxybenzophenone
fenofibrate
Conditions | Yield |
---|---|
With potassium carbonate In water | |
Multi-step reaction with 2 steps 1: sodium hydroxide 2: sulfuric acid View Scheme |
2-(4-chlorophenyl)-1,3-dithiane
isopropyl 2-(4-bromophenoxy)-2-methylpropanoate
fenofibrate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: bis(η3-allyl-μ-chloropalladium(II)); lithium hexamethyldisilazane; nixantphos / 3 h / 20 °C / Schlenk technique; Sealed tube; Inert atmosphere 2: N-Bromosuccinimide; water / 1.5 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: nixantphos; bis(η3-allyl-μ-chloropalladium(II)); lithium hexamethyldisilazane / tetrahydrofuran / 3 h / 24 °C / Sealed tube; Inert atmosphere; Schlenk technique 2: N-Bromosuccinimide; water / tetrahydrofuran / 1.5 h / 24 °C View Scheme |
fenofibrate
Conditions | Yield |
---|---|
With N-Bromosuccinimide; water at 20℃; for 1.5h; | 3.1 g |
With N-Bromosuccinimide; water In tetrahydrofuran at 24℃; for 1.5h; | 3.1 g |
4-Hydroxyacetophenone
fenofibrate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: potassium carbonate / acetonitrile / 12 h / 90 °C 2: selenium(IV) oxide; pyridine / 14 h / 110 °C 3: (1,2-dimethoxyethane)dichloronickel(II); [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate; lithium carbonate; 4,4'-di-tert-butyl-2,2'-bipyridine / N,N-dimethyl-formamide; water / 96 h / Inert atmosphere; Irradiation View Scheme |
isopropyl 2-bromo-2‑methylpropanoate
fenofibrate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: potassium carbonate / acetonitrile / 12 h / 90 °C 2: selenium(IV) oxide; pyridine / 14 h / 110 °C 3: (1,2-dimethoxyethane)dichloronickel(II); [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate; lithium carbonate; 4,4'-di-tert-butyl-2,2'-bipyridine / N,N-dimethyl-formamide; water / 96 h / Inert atmosphere; Irradiation View Scheme |
fenofibrate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere; Schlenk technique 2: potassium carbonate / acetonitrile / 18 h / Inert atmosphere; Schlenk technique; Reflux View Scheme |
4-fluoroboronic acid
fenofibrate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: C42H36ClFeN2O4PPdS*C6H15N; sodium carbonate / water; toluene / 1 h / 50 °C / Inert atmosphere; Schlenk technique 2: sodium hydroxide / water; dimethyl sulfoxide / 16 h / 120 °C / Inert atmosphere; Schlenk technique 3: potassium carbonate / acetonitrile / 18 h / Inert atmosphere; Schlenk technique; Reflux View Scheme |
4-fluorobenzoyl chloride
fenofibrate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: C42H36ClFeN2O4PPdS*C6H15N; sodium carbonate / water; toluene / 1 h / 50 °C / Inert atmosphere; Schlenk technique 2: sodium hydroxide / water; dimethyl sulfoxide / 16 h / 120 °C / Inert atmosphere; Schlenk technique 3: potassium carbonate / acetonitrile / 18 h / Inert atmosphere; Schlenk technique; Reflux View Scheme |
4-Chlorophenylboronic acid
fenofibrate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: C42H36ClFeN2O4PPdS*C6H15N; sodium carbonate / water; toluene / 1 h / 50 °C / Inert atmosphere; Schlenk technique 2: sodium hydroxide / water; dimethyl sulfoxide / 16 h / 120 °C / Inert atmosphere; Schlenk technique 3: potassium carbonate / acetonitrile / 18 h / Inert atmosphere; Schlenk technique; Reflux View Scheme |
Conditions | Yield |
---|---|
In ethanol at 80℃; for 5h; Solvent; Large scale; | 100% |
fenofibrate
fenofibric acid
Conditions | Yield |
---|---|
With water; triethylamine; lithium bromide In acetonitrile for 7h; Heating; | 99% |
With iodine; aluminium In acetonitrile at 80℃; for 18h; | 97% |
With sodium hydroxide In methanol at 69.85℃; for 4h; | 85% |
Dibenzothiophene sulfoxide
trifluoromethylsulfonic anhydride
fenofibrate
Conditions | Yield |
---|---|
In dichloromethane at -40 - 25℃; for 0.5h; Schlenk technique; Inert atmosphere; Glovebox; | 98% |
fenofibrate
Conditions | Yield |
---|---|
With silver hexafluoroantimonate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; 2-methyl-3-trifluoromethylaniline; water-d2; para-chlorobenzoic acid In 1,2-dichloro-ethane at 120℃; for 16h; Schlenk technique; Inert atmosphere; | 98% |
fenofibrate
4-((4-chlorophenyl)(hydroxy)methyl)phenol
Conditions | Yield |
---|---|
With C28H35ClCoN5(1+)*Cl(1-); potassium tert-butylate; hydrogen In tetrahydrofuran at 20℃; under 37503.8 Torr; for 16h; Pressure; Temperature; Autoclave; | 97% |
With potassium borohydride |
fenofibrate
isopropyl 2-(4-(4-deuteriobenzoyl)phenoxy)-2-methylpropanoate
Conditions | Yield |
---|---|
With bis(η3-allyl-μ-chloropalladium(II)); 1-deuteriodiphenylmethanol; 3-(2,6-dibenzhydryl-4-methylphenyl)-4,5-dimethyl-1-(2,4,6-trimethylbenzyl)imidazolium chloride; caesium carbonate In toluene at 90℃; for 16h; Inert atmosphere; | 95% |
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; d8-isopropanol; potassium carbonate; bis(dibenzylideneacetone)-palladium(0) In acetonitrile at 100℃; for 2.5h; Inert atmosphere; Microwave irradiation; | 90% |
fenofibrate
Conditions | Yield |
---|---|
With 1,1,1,3,3,3-hexamethyl-disilazane; scandium tris(trifluoromethanesulfonate) In chlorobenzene at 90℃; for 24h; Inert atmosphere; | 93% |
Conditions | Yield |
---|---|
With potassium phosphate monohydrate; tris(1-adamantyl)phosphine; C28H26N2O8Pd2S2 In tetrahydrofuran; toluene at 100℃; for 5h; Suzuki-Miyaura Coupling; Inert atmosphere; Schlenk technique; | 92% |
With potassium phosphate monohydrate; tris(1-adamantyl)phosphine; {2-[((acetyl-κO)amino)phenyl-κC](tri-1-adamantylphosphine)palladium}(p-toluenesulfonate) In tetrahydrofuran; toluene at 100℃; for 5h; Suzuki-Miyaura Coupling; Inert atmosphere; | 92% |
Conditions | Yield |
---|---|
With potassium phosphate monohydrate; palladium diacetate; N2Phos In water; toluene at 45℃; for 16h; Suzuki-Miyaura Coupling; | 92% |
With C35H47O3P*C15H16N(1-)*CH3O3S(1-)*Pd(2+); triethylamine In tetrahydrofuran; water at 45℃; for 24h; Suzuki-Miyaura Coupling; | 91% |
fenofibrate
3-trifluoromethylaniline
Conditions | Yield |
---|---|
With methanesulfonato(2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II); potassium hydroxide In water; toluene at 110℃; Flow reactor; | 91% |
Conditions | Yield |
---|---|
With C17H24N5Ru(1+)*F6P(1-); potassium acetate; potassium carbonate In 1-methyl-pyrrolidin-2-one at 35℃; for 24h; Inert atmosphere; | 90% |
With C17H24N5Ru(1+)*F6P(1-); potassium acetate; potassium carbonate In 1-methyl-pyrrolidin-2-one at 35℃; for 24h; Inert atmosphere; Glovebox; | 90% |
fenofibrate
1-phenyl-2-bromoethane
Conditions | Yield |
---|---|
With 2.9-dimethyl-1,10-phenanthroline; nickel(II) perchlorate hexahydrate; tetrabutylammomium bromide In N,N-dimethyl acetamide at 20℃; for 10h; Glovebox; Sealed tube; Electrochemical reaction; Inert atmosphere; regioselective reaction; | 90% |
fenofibrate
4-fluoroaniline
Conditions | Yield |
---|---|
With Pd(PAd3)(4-FC6H4)Br; triethylamine In water; toluene at 100℃; for 36h; Solvent; Temperature; Inert atmosphere; Glovebox; | 90% |
Conditions | Yield |
---|---|
Stage #1: 2-methyl-4,5-dihydro-1,3-oxazole; fenofibrate With magnesium(II) perchlorate In acetonitrile at 20℃; Inert atmosphere; Electrochemical reaction; Stage #2: With sodium hydrogencarbonate In hexane; water; ethyl acetate Inert atmosphere; chemoselective reaction; | 88% |
Conditions | Yield |
---|---|
With tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; C20H28N4O2Pd(2+)*2BF4(1-) In acetonitrile at 23℃; for 24h; regioselective reaction; | 88% |
fenofibrate
isopropyl 2-(4-(4-hydroxybenzoyl)phenoxy)-2-methylpropanoate
Conditions | Yield |
---|---|
With tris(6,6'-diamino-2,2'-bipyridine); 4,4-diphenyl-1,3,5,7,8-pentamethyl-2,6-diethyl-4-bora-3a,4a-diaza-s-indacene; Br2Ni*3H2O; water; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide; acetonitrile at 20℃; for 24h; Glovebox; Irradiation; Inert atmosphere; | 88% |
With acetylhydroxamic acid; potassium carbonate In dimethyl sulfoxide at 80℃; for 40h; Sealed tube; | 46% |
fenofibrate
Conditions | Yield |
---|---|
With dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; [(2-di-cyclohexylphosphino-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1‘-biphenyl)-2-(2‘-amino-1,1’-biphenyl)]palladium(II) methanesulfonate In tetrahydrofuran at 80℃; for 2h; Inert atmosphere; Schlenk technique; | 88% |
Conditions | Yield |
---|---|
With trifluoroacetic anhydride In acetonitrile at 0 - 23℃; under 760.051 Torr; for 2h; | 88% |
fenofibrate
acetone
Conditions | Yield |
---|---|
With bis(1,5-cyclooctadiene)nickel (0); (R)-1-[(Sp)-2-(dicyclohexylphosphanyl)ferrocenylethyl]diphenylphosphane; cesium fluoride at 120℃; for 18h; Reagent/catalyst; Inert atmosphere; | 88% |
fenofibrate
Conditions | Yield |
---|---|
With caesium carbonate; palladium dichloride; ruphos In tetrahydrofuran; water at 85℃; for 20h; Sealed tube; Inert atmosphere; | 86% |
Suzuki Coupling; Schlenk technique; | |
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium carbonate In 1,4-dioxane; water at 90℃; Schlenk technique; Inert atmosphere; | |
With caesium carbonate; palladium dichloride; ruphos In tetrahydrofuran; water at 85℃; for 20h; Inert atmosphere; Sealed tube; |
1-fluoro-2-iodoethane
fenofibrate
Conditions | Yield |
---|---|
With manganese; 4,4'-Dimethoxy-2,2'-bipyridin; magnesium chloride; nickel dibromide In 1-methyl-pyrrolidin-2-one at 80℃; for 24h; Schlenk technique; Inert atmosphere; Sealed tube; | 86% |
With manganese; 4,4'-Dimethoxy-2,2'-bipyridin; magnesium chloride; nickel dibromide In 1-methyl-pyrrolidin-2-one at 80℃; for 24h; Inert atmosphere; Sealed tube; | 86% |
Conditions | Yield |
---|---|
With (1,2-dimethoxyethane)dichloronickel(II); lithium perchlorate; potassium carbonate; 4,4'-di-tert-butyl-2,2'-bipyridine In N,N-dimethyl-formamide at 20℃; Electrochemical reaction; Inert atmosphere; Glovebox; | 86% |
1,1,1-trifluoro-2-chloroethane
fenofibrate
Conditions | Yield |
---|---|
With 4,4'-di-tert-butyl-2,2'-bipyridine; magnesium chloride; nickel dibromide; zinc In N,N-dimethyl acetamide at 80℃; for 12h; Inert atmosphere; Schlenk technique; | 85% |
Fenofibrate (CAS NO.49562-28-9) was discovered by Groupe Fournier SA, before it was acquired in 2005 by Solvay Pharmaceutical, a business unit owned by the Belgian corporation, Solvay S.A. Fenofibrate is sold under the brand name Tricor and Trilipix by Abbott Labs, Lipofen by Kowa Pharmaceuticals America Inc, Lofibra by Teva, Lipanthyl and Lipidil by Solvay Pharmaceutical and Fenocor-67 by Ordain Health Care Pvt Ltd.
The pharmaceutical form and the strength may change from one country to another, and from one brand to another. In the United States, Tricor was reformulated in 2005 and is available in tablets of 48 and 145 mg. This reformulation is controversial and is the subject of antitrust litigation by generic drug manufacturer Teva. Also available in the United States, Lofibra is available in 54 and 160 mg tablets, as well as 67, 134, and 200 mg micronized capsules. Generic equivalents of Lofibra capsules are currently available in all three strengths in the United States. In Europe, it is available in either coated tablet or capsule; the strength range includes 67, 145, 160 and 200 mg. The differences among strengths are a result of altered bioavailability (the fraction absorbed by the body) due to particle size. For example, 200 mg can be replaced by 160 mg micronized fenofibrate. The 145 mg strength is a new strength appeared in 2005-2006 which also replaces 200 or 160 mg as the fenofibrate is nanonised (ie the particle size is below 400 nm).
Fenofibrate, with the IUPAC Name of propan-2-yl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate, is one kind of drug. This chemical belongs to the Product Categories which include Active Pharmaceutical Ingredients; Intermediates & Fine Chemicals; Pharmaceuticals; Intracellular receptor. It is mainly used to reduce Cholesterol levels in patients at risk of cardiovascular disease. Like other fibrates, it reduces both low-density lipoprotein (LDL) and very low density lipoprotein (VLDL) levels, as well as increasing high-density lipoprotein (HDL) levels and reducing tryglycerides level. It also appears to have a beneficial effect on the Insulin resistance featured by the metabolic syndrome. It is used alone or in conjunction with statins in the treatment of hyperCholesterolemia and hypertriglyceridemia.
Physical properties about Fenofibrate are: (1)ACD/LogP: 5.801; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): 5.80; (4)ACD/LogD (pH 7.4): 5.80; (5)ACD/BCF (pH 5.5): 15087.66; (6)ACD/BCF (pH 7.4): 15087.66; (7)ACD/KOC (pH 5.5): 34091.39; (8)ACD/KOC (pH 7.4): 34091.39; (9)#H bond acceptors: 4; (10)#Freely Rotating Bonds: 7; (11)Index of Refraction: 1.547; (12)Molar Refractivity: 97.116 cm3; (13)Molar Volume: 306.449 cm3; (14)Polarizability: 38.5 10-24cm3; (15)Surface Tension: 40.9819984436035 dyne/cm; (16)Density: 1.177 g/cm3; (17)Flash Point: 165.356 °C; (18)Enthalpy of Vaporization: 73.22 kJ/mol; (19)Boiling Point: 469.774 °C at 760 mmHg; (20)Vapour Pressure: 0 mmHg at 25°C
When you are using Fenofibrate, please be cautious about it as the following:
1.Wear suitable protective clothing;
2. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice;
You could convert the following datas into the molecular structure:
(1)InChI=1S/C20H21ClO4/c1-13(2)24-19(23)20(3,4)25-17-11-7-15(8-12-17)18(22)14-5-9-16(21)10-6-14/h5-13H,1-4H3;
(2)InChIKey=YMTINGFKWWXKFG-UHFFFAOYSA-N;
(3)Smilesc1(C(c2ccc(Cl)cc2)=O)ccc(OC(C(OC(C)C)=O)(C)C)cc1
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | oral | > 4gm/kg (4000mg/kg) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 23(Suppl, | |
hamster | LD50 | oral | > 5gm/kg (5000mg/kg) | American Journal of Medicine. Vol. 83(Suppl, | |
mouse | LD50 | oral | 1600mg/kg (1600mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 885, 1976. | |
rat | LD50 | oral | > 2gm/kg (2000mg/kg) | LIVER: OTHER CHANGES | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 23(Suppl, |
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