Guanosine 5'-monophosphate disodium salt supplier

Name
Guanosine 5'-monophosphate disodium salt
EINECS 226-914-1
CAS No. 5550-12-9
Article Data3
CAS DataBase
Density
Solubility >50 g/L in water
Melting Point 300 °C
Formula C₁₀H₁₂N₅Na₂O₈P
Boiling Point 890.2oC at 760 mmHg
Molecular Weight 407.187
Flash Point 492.2oC
Transport Information
Appearance White crystalline powder
Safety 22-24/25-36/37/39-27-26
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 5'-Guanylicacid, disodium salt (7CI,8CI,9CI);5'-GMP disodium salt;Disodium 5'-GMP;Disodium 5'-guanylate;Disodium GMP;Disodium guanosine 5'-monophosphate;Disodium guanosine 5'-phosphate;Disodium guanylate;E 627;GMP disodium salt;GMP sodium salt;Guanosine 5'-monophosphate disodium salt;Guanosine5'-phosphate disodium salt;Guanylic acid sodium salt;NSC 20265;Sodium5'-guanylate;Sodium GMP;Sodium guanosine 5'-monophosphate;Sodium guanylate;
PSA 221.51000
LogP -1.11210

Synthetic route

: guanosine-5'-phosphoro-(2-aminoimidazole)

A: 7720-39-0
1H-imidazol-2-amine

B: 5550-12-9
guanosine 5'-monophosphate disodium

Conditions

Conditions	Yield
With trimethyl phosphite; water; sodium chloride; magnesium chloride; N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid In water-d2 at 25℃; Kinetics;

: 80242-42-8
guanosine-5'-(2-methylimidazol-1-yl phosphate)

A: 693-98-1
2-methylimidazole

B: 5550-12-9
guanosine 5'-monophosphate disodium

Conditions

Conditions	Yield
With trimethyl phosphite; water; sodium chloride; magnesium chloride; N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid In water-d2 at 25℃; Kinetics;

: C10H14N6O10P2(2-)*2Na(1+)

: 5550-12-9
guanosine 5'-monophosphate disodium

Conditions

Conditions	Yield
With water; zinc(II) cation pH=5.5;

: 5550-12-9
guanosine 5'-monophosphate disodium

: 85-32-5
5'-guanosine monophosphate

Conditions

Conditions	Yield
With Dowex 50W×8 resin In water at 20℃; for 0.5h;	99%
With Dowex 50WX-8 200 mesh, H+

: 288-32-4
1H-imidazole

: 5550-12-9
guanosine 5'-monophosphate disodium

: 121-44-8
triethylamine

: triethylammonium guanosin-5'-yl monophosphate P-imidazolide

Conditions

Conditions	Yield
With 2,2'-dipyridyldisulphide; triphenylphosphine In N,N-dimethyl-formamide at 20℃;	90%

...Expand

: 5550-12-9
guanosine 5'-monophosphate disodium

: 874-98-6
1-bromomethyl-3-methoxybenzene

: ((2R,3S,4R,5R)-5-(2-amino-7-(3-methoxybenzyl)-6-oxo-1H-purin-1-ium-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Conditions

Conditions	Yield
In dimethyl sulfoxide at 20℃; for 24h;	81%

: 15663-27-1
cisplatin

: 5550-12-9
guanosine 5'-monophosphate disodium

: cis-[Pt(NH3)2(5'-guanosine monophosphateNa2)2]Cl2

Conditions

Conditions	Yield
In water mixture is heated at 50°C for about 3-5 h with stirring; the clear soln. is left overnight at room temp.;; concn. under vacuum; pptn. with acetone, then with ether; white ppt. isfiltered off, washed with acetone, then with ether and dried in air;;	75%
In water stirring Pt-complex with 2 equiv. of ligand (room temp., 3 h, in dark);

: 5550-12-9
guanosine 5'-monophosphate disodium

: 622-95-7
4-chlorobenzyl bromide

: ((2R,3S,4R,5R)-5-(2-amino-7-(4-chlorobenzyl)-6-oxo-1H-purin-1-ium-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Conditions

Conditions	Yield
In dimethyl sulfoxide at 20℃; for 24h;	75%

: 5550-12-9
guanosine 5'-monophosphate disodium

: 89-92-9
2-methylbenzyl bromide

: ((2R,3S,4R,5R)-5-(2-amino-7-(2-methylbenzyl)-6-oxo-1H-purin-1-ium-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Conditions

Conditions	Yield
In dimethyl sulfoxide at 20℃; for 24h;	71%

: 5550-12-9
guanosine 5'-monophosphate disodium

: 100-39-0
benzyl bromide

: ((2R,3S,4R,5R)-5-(2-amino-7-benzyl-6-oxo-1H-purin-1-ium-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Conditions

Conditions	Yield
In dimethyl sulfoxide at 20℃; for 24h;	70%

: 2466-76-4
N-Acetylimidazole

: 5550-12-9
guanosine 5'-monophosphate disodium

: 2′,3′-di-O-acetyl β-guanosine-5′-phosphate

Conditions

Conditions	Yield
With sodium hydroxide In water at 20℃; for 4h; pH=8;	70%

: 5550-12-9
guanosine 5'-monophosphate disodium

: guanosine 5′-(2-fluorodiphosphate) disodium salt

Conditions

Conditions	Yield
With fluorophosphate imidazolide lithium salt; magnesium chloride In N,N-dimethyl-formamide for 2h;	69%

: 110-91-8
morpholine

: 5550-12-9
guanosine 5'-monophosphate disodium

: 538-75-0
dicyclohexyl-carbodiimide

: 7390-53-6
guanosine-5'-monophosphate morpholidate

Conditions

Conditions	Yield
Stage #1: morpholine; guanosine 5'-monophosphate disodium With Dowex 50W-X8 resin In water Stage #2: morpholine; dicyclohexyl-carbodiimide In tert-butyl alcohol at 100℃; for 5h; Further stages.;	68%

...Expand

: 5550-12-9
guanosine 5'-monophosphate disodium

: 939-26-4
2-bromomethylnaphthyl bromide

: ((2R,3S,4R,5R)-5-(2-amino-7-(naphthalen-2-ylmethyl)-6-oxo-1H-purin-1-ium-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Conditions

Conditions	Yield
In dimethyl sulfoxide at 20℃; for 24h;	68%

: 5550-12-9
guanosine 5'-monophosphate disodium

: 611-17-6
1-bromomethyl-2-chlorobenzene

: ((2R,3S,4R,5R)-5-(2-amino-7-(2-chlorobenzyl)-6-oxo-1H-purin-1-ium-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Conditions

Conditions	Yield
In dimethyl sulfoxide at 20℃; for 24h;	67%

: 5550-12-9
guanosine 5'-monophosphate disodium

: 85482-13-9
2,5-dichlorobenzylbromide

: ((2R,3S,4R,5R)-5-(2-amino-7-(2,5-dichlorobenzyl)-6-oxo-1H-purin-1-ium-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Conditions

Conditions	Yield
In dimethyl sulfoxide at 20℃; for 24h;	64%

: 6232-88-8
4-bromomethylbenzoic Acid

: 5550-12-9
guanosine 5'-monophosphate disodium

: ((2R,3S,4R,5R)-5-(2-amino-7-(4-carboxybenzyl)-6-oxo-1H-purin-1-ium-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Conditions

Conditions	Yield
In dimethyl sulfoxide at 20℃; for 24h;	62%

: cis-{Pt(NH3)2(1-methylimidazole-N3)Cl}NO3

: 5550-12-9
guanosine 5'-monophosphate disodium

: cis-{Pt(NH3)2(1-methylimidazole-N3)(5'-guanosinemonophosphate-N7)} * 4 H2O

Conditions

Conditions	Yield
With water In water dissolving cis-(Pt(NH3)2(C3H3N2(CH3))Cl)NO3 in H2O, addn. of disodium salt of 5'-guanosinemonophosphate; warming to 50°C for 50 h;; filtering, concg. under reduced pressure; addn. of abs. ethanol (pptn.); elem. anal.;;	60%

: 5550-12-9
guanosine 5'-monophosphate disodium

: 459-46-1
4-Fluorobenzyl bromide

: ((2R,3S,4R,5R)-5-(2-amino-7-(4-fluorobenzyl)-6-oxo-1H-purin-1-ium-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Conditions

Conditions	Yield
In dimethyl sulfoxide at 20℃; for 24h;	56%

: hexammine cobalt(III) chloride

: 5550-12-9
guanosine 5'-monophosphate disodium

: 2Co(NH3)6(3+)*3(O3POCH2(CHCH(OH)CH(OH)CH(C5H2N4O(NH2))O))(2-)*13H2O={Co(NH3)6}2{C10H12N5PO8}3*13H2O

Conditions

Conditions	Yield
In water Dropwise addn. of Co-complex soln. to soln. of Na2(5'-GMP);; Cooling in a refrigerator, filtn., washing of orange solid (cold H2O), drying in a desiccator, elem. anal.;	54%

: 620-13-3
1-bromomethyl-3-methyl-benzene

: 5550-12-9
guanosine 5'-monophosphate disodium

: ((2R,3S,4R,5R)-5-(2-amino-7-(3-methylbenzyl)-6-oxo-1H-purin-1-ium-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Conditions

Conditions	Yield
In dimethyl sulfoxide at 20℃; for 24h;	51%

: 446-48-0
o-fluorobenzyl bromide

: 5550-12-9
guanosine 5'-monophosphate disodium

: ((2R,3S,4R,5R)-5-(2-amino-7-(2-fluorobenzyl)-6-oxo-1H-purin-1-ium-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Conditions

Conditions	Yield
In dimethyl sulfoxide at 20℃; for 24h;	48%

: 5550-12-9
guanosine 5'-monophosphate disodium

: 81778-09-8
1-(bromomethyl)-2-chloro-5-fluorobenzene

: ((2R,3S,4R,5R)-5-(2-amino-7-(2-chloro-5-fluorobenzyl)-6-oxo-1H-purin-1-ium-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Conditions

Conditions	Yield
In dimethyl sulfoxide at 20℃; for 24h;	41%

: 5550-12-9
guanosine 5'-monophosphate disodium

: 622-95-7
4-chlorobenzyl bromide

: 76-05-1
trifluoroacetic acid

: 7-(4-chlorobenzyl)guanosine-5'-monophosphate trifluoroacetate

Conditions

Conditions	Yield
Stage #1: guanosine 5'-monophosphate disodium; 4-chlorobenzyl bromide In dimethyl sulfoxide for 22h; Stage #2: trifluoroacetic acid In water; acetonitrile for 0.5h;	38%

...Expand

: 5550-12-9
guanosine 5'-monophosphate disodium

: 3958-57-4
1-bromomethyl-3-nitrobenzene

: ((2R,3S,4R,5R)-5-(2-amino-7-(3-nitrobenzyl)-6-oxo-1H-purin-1-ium-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Conditions

Conditions	Yield
In dimethyl sulfoxide at 20℃; for 24h;	37%

: 5550-12-9
guanosine 5'-monophosphate disodium

: 8-trifluoromethylguanosine 5′-monophosphate ammonium salt

Conditions

Conditions	Yield
Stage #1: guanosine 5'-monophosphate disodium With tert.-butylhydroperoxide In water; acetic acid; dimethyl sulfoxide at 0 - 20℃; for 72h; Stage #2: With ammonium acetate In acetonitrile pH=5.9;	35%

: 5550-12-9
guanosine 5'-monophosphate disodium

: 402-23-3
1-bromomethyl-3-trifluoromethylbenzene

: ((2R,3S,4R,5R)-5-(2-amino-6-oxo-7-(3-(trifluoromethyl)benzyl)-1H-purin-1-ium-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Conditions

Conditions	Yield
In dimethyl sulfoxide at 20℃; for 24h;	34%

: 5550-12-9
guanosine 5'-monophosphate disodium

: 766-80-3
1-bromomethyl-3-chlorobenzene

: ((2R,3S,4R,5R)-5-(2-amino-7-(3-chlorobenzyl)-6-oxo-1H-purin-1-ium-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Conditions

Conditions	Yield
In dimethyl sulfoxide at 20℃; for 24h;	33%

: 5550-12-9
guanosine 5'-monophosphate disodium

: 456-41-7
1-(Bromomethyl)-3-fluorobenzene

: ((2R,3S,4R,5R)-5-(2-amino-7-(3-fluorobenzyl)-6-oxo-1H-purin-1-ium-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Conditions

Conditions	Yield
In dimethyl sulfoxide at 20℃; for 24h;	32%

: 5550-12-9
guanosine 5'-monophosphate disodium

: 456-41-7
1-(Bromomethyl)-3-fluorobenzene

: ((2R,3S,4R,5R)-5-(2-amino-7-(3-fluorobenzyl)-6-oxo-1,6-dihydro-9H-purin-7-ium-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate

Conditions

Conditions	Yield
In dimethyl sulfoxide at 20℃; for 18h; Inert atmosphere;	32%

: butynediazo acetamide

: 5550-12-9
guanosine 5'-monophosphate disodium

: C16H19N6O9P(2-)

Conditions

Conditions	Yield
With copper(II) sulfate; sodium L-ascorbate In water at 20℃; for 1h;	31%

: 6-amino-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)hexanamide

: 5550-12-9
guanosine 5'-monophosphate disodium

: ((2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydro-furan-2-yl)methylhydrogen(6-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)amino)-6-oxohexyl)phosphoramidate

Conditions

Conditions	Yield
With 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water; dimethyl sulfoxide at 25℃; pH=7.2;	31%

: 110-91-8
morpholine

: 5550-12-9
guanosine 5'-monophosphate disodium

: guanosine-5′-phosphoromorpholidate

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In water; tert-butyl alcohol at 100℃; for 5h; Reagent/catalyst;	27%

Guanosine 5'-monophosphate disodium salt Chemical Properties

IUPAC Name:disodium [5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate
Molecular Formula:C₁₀H₁₂N₅Na₂O₈P
Molecular Weight:407.184281 g/mol
Appearance:White crystalline powder
Melting Point:300 °C
Solubility:slightly soluble in ethanol, acetone and ether
storage temp.:2-8 °C
Water Solubility:>50 g/L
FEMA:3668
EINECS:226-914-1
Synonyms of GUANYLIC ACID SODIUM SALT(5550-12-9):
GMP-5;5’-gmpdisodiumsalt;disodium5’-gmp;disodiumgmp;gmpsodiumsalt;sodium5’-guanylate;sodiumgmp;sodiumguanosine5’-monophosphate;Guanosine 5'-monophosphate disodium salt
Categories of GUANYLIC ACID SODIUM SALT(5550-12-9):
Pharmaceutical Intermediates;Biochemistry;Nucleosides, Nucleotides & Related Reagents;Nucleotides and their analogs;Nucleic acids

Guanosine 5'-monophosphate disodium salt Uses

GUANYLIC ACID SODIUM SALT(5550-12-9) is mainly used as a condiment.

Guanosine 5'-monophosphate disodium salt Toxicity Data With Reference

1.	cyt-ham:fbr 1 g/L	FCTOD7 Food and Chemical Toxicology. 22 (1984),623.
2.	ipr-rat LD50:3880 mg/kg	AJINO* Ajinomoto Co., Inc. (9W. 57th St., Suite 4625, New York, NY 10019)
3.	scu-rat LD50:3400 mg/kg	AJINO* Ajinomoto Co., Inc. (9W. 57th St., Suite 4625, New York, NY 10019)
4.	ivn-rat LD50:2720 mg/kg	AJINO* Ajinomoto Co., Inc. (9W. 57th St., Suite 4625, New York, NY 10019)
5.	orl-mus LD50:15 g/kg	AJINO* Ajinomoto Co., Inc. (9W. 57th St., Suite 4625, New York, NY 10019)
6.	ipr-mus LD50:5010 mg/kg	AJINO* Ajinomoto Co., Inc. (9W. 57th St., Suite 4625, New York, NY 10019)
7.	scu-mus LD50:5050 mg/kg	AJINO* Ajinomoto Co., Inc. (9W. 57th St., Suite 4625, New York, NY 10019)
8.	ivn-mus LD50:3580 mg/kg	AJINO* Ajinomoto Co., Inc. (9W. 57th St., Suite 4625, New York, NY 10019)

Guanosine 5'-monophosphate disodium salt Consensus Reports

Reported in EPA TSCA Inventory.

Guanosine 5'-monophosphate disodium salt Safety Profile

Safety Information of GUANYLIC ACID SODIUM SALT(5550-12-9):
Hazard Codes:Xi
Risk Statements:36/37/38
36/37/38:Irritating to eyes, respiratory system and skin
Safety Statements:22-24/25-36/37/39-27-26
22:Do not breathe dust
24/25:Avoid contact with skin and eyes
36/37/39:Wear suitable protective clothing, gloves and eye/face protection
27:Take off immediately all contaminated clothing
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
WGK Germany:2
RTECS:MF9290000
Moderately toxic by intraperitoneal, subcutaneous, and intravenous routes. Mildly toxic by ingestion. Mutation data reported. When heated to decomposition it emits toxic fumes of PO_x, NO_x, and Na₂O.

Product Name

Guanosine 5'-monophosphate disodium salt

Synthetic route

Guanosine 5'-monophosphate disodium salt Chemical Properties

Guanosine 5'-monophosphate disodium salt Uses

Guanosine 5'-monophosphate disodium salt Toxicity Data With Reference

Guanosine 5'-monophosphate disodium salt Consensus Reports

Guanosine 5'-monophosphate disodium salt Safety Profile

Related Products

Hot Products