methanol
L-phenylalanine
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
Conditions | Yield |
---|---|
With thionyl chloride 1.) from 0 deg C to RT, 100 min, 2.) reflux, 2 h; | 100% |
With thionyl chloride for 2h; Heating; | 100% |
With thionyl chloride at 20℃; | 100% |
Conditions | Yield |
---|---|
With thionyl chloride In methanol | 100% |
With thionyl chloride In methanol at 0 - 20℃; | 100% |
With thionyl chloride In methanol | 98% |
(S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In ethyl acetate at 0℃; for 2h; | 100% |
With hydrogenchloride In 1,4-dioxane for 2h; | |
With hydrogenchloride In 1,4-dioxane at 21 - 23℃; for 1h; | |
With hydrogenchloride In 1,4-dioxane at 21 - 23℃; for 1h; |
L-phenylalanine
2,2-dimethoxy-propane
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride at 20℃; for 18h; | 99% |
With hydrogenchloride Ambient temperature; | |
With hydrogenchloride at 20℃; |
N-formyl-L-phenylalanine-methylester
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In methanol for 1h; Heating; | 99% |
chloro-trimethyl-silane
L-phenylalanine
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
Conditions | Yield |
---|---|
In methanol at 20℃; for 24h; | 99% |
methanol
(S)-3-amino-4-phenyl-2-butanone
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
Conditions | Yield |
---|---|
With thionyl chloride at 0 - 80℃; for 4.5h; | 98% |
(S)-methyl 2-(2,4-dinitrophenylsulfonamido)-3-phenylpropanoate
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
Conditions | Yield |
---|---|
Stage #1: (S)-methyl 2-(2,4-dinitrophenylsulfonamido)-3-phenylpropanoate With thiophenol In N,N-dimethyl-formamide at 20℃; for 0.25h; Stage #2: With hydrogenchloride | 96% |
2-methyl-propan-1-ol
(S)-N-acetylphenylalanine
A
2-methylpropyl acetate
B
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
Conditions | Yield |
---|---|
Stage #1: (S)-N-acetylphenylalanine With triphenyl phosphite; chlorine; triethylamine In tetrahydrofuran at -30℃; Stage #2: 2-methyl-propan-1-ol In tetrahydrofuran at -30 - 20℃; Stage #3: With water | A n/a B 95% |
methanol
L-phenylalanine hydrochloride
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
Conditions | Yield |
---|---|
With thionyl chloride at -10 - 20℃; for 16h; | 95% |
With thionyl chloride at 0℃; | 93% |
With acetyl chloride at 20℃; for 0.5h; |
methanol
N-tert-butoxycarbonyl-L-phenylalanine
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
Conditions | Yield |
---|---|
With chloro-trimethyl-silane at 20℃; for 19h; Esterification; de-tert-butoxycarbonylation; | 94% |
With thionyl chloride at 50℃; for 5h; Inert atmosphere; |
methyl N-{[2-(trimethylsilyl)ethyl]sulfonyl}-L-phenylalaninate
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
Conditions | Yield |
---|---|
With cesium fluoride In N,N-dimethyl-formamide at 95℃; for 10h; | 87% |
(S)-methyl 2-(2-nitrophenylsulfonamido)-3-phenylpropanoate
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
Conditions | Yield |
---|---|
Stage #1: (S)-methyl 2-(2-nitrophenylsulfonamido)-3-phenylpropanoate With 1,8-diazabicyclo[5.4.0]undec-7-ene; 2-hydroxyethanethiol In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: With hydrogenchloride | 81% |
(S)-2-benzylamino-3-phenyl-propionic acid methyl ester
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
Conditions | Yield |
---|---|
Stage #1: (S)-2-benzylamino-3-phenyl-propionic acid methyl ester With tert.-butylhydroperoxide; dirhodium(II) tetrakis(caprolactam) In acetonitrile at 20℃; for 16h; Stage #2: With hydrogenchloride In diethyl ether at 20℃; for 6h; | 78% |
methyl (S)-3-phenyl-2-(1H-pyrrol-1-yl)propanoate
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
Conditions | Yield |
---|---|
Stage #1: methyl (S)-3-phenyl-2-(1H-pyrrol-1-yl)propanoate With ozone In methanol at -78℃; for 2.5h; Inert atmosphere; Stage #2: With thiourea In methanol at -78 - 0℃; for 1.5h; Inert atmosphere; Stage #3: With hydrogenchloride In 1,4-dioxane; methanol at 0 - 20℃; for 6h; Inert atmosphere; | 71% |
N-formyl-L-phenylalanine
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride |
methanol
DL-β-chloro-β-phenylalanine hydrochloride
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
Conditions | Yield |
---|---|
Yield given. Multistep reaction; |
NPS-Phe-OMe
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In diethyl ether |
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In diethyl ether at 20℃; Hydrolysis; |
L-phenylalanine
methyl iodide
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
Conditions | Yield |
---|---|
Stage #1: L-phenylalanine With thionyl chloride Stage #2: methyl iodide |
methanol
Phe-Chlor
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: LDA / tetrahydrofuran / -78 °C 1.2: 85 percent / tetrahydrofuran / -78 °C 2.1: aq. HCl / diethyl ether / 20 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 94 percent / dicyclohexylcarbodi-imide, 4-dimethylaminopyridine / 1) 0 deg C, 5 min, 2) 25 deg C, 3 h 2: HCl / diethyl ether View Scheme |
(R,S)-2-amino-3-phenylpropionamide
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: enzymatic hydrolysis with pronase immobilized on ketonic polymer; effects of pH, substrat concentration, catalyst mass 2: 99 percent / SOCl2 / 3 h / Heating View Scheme |
methyl (2S)-2-amino-3-phenylpropanoate
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In water |
C10H13NO2*C30H46N2O4*ClH
A
(6S,17S)-1,4-di[N-(S)-α-phenylethyl]-1,4-diaza-6,17-dimethyl-7,10,13,19-tetraoxacyclooctadecane
B
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
Conditions | Yield |
---|---|
In chloroform-d1; d(4)-methanol Equilibrium constant; Inert atmosphere; |
C10H13NO2*C34H46N2O4*ClH
A
(6S,17S)-1,4-di[N-(S)-α-phenylethyl]-1,4-diaza-6,17-dimethyl-11,12-benzo-7,10,13,19-tetraoxacyclooctadec-11-ene
B
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
Conditions | Yield |
---|---|
In chloroform-d1; d(4)-methanol Equilibrium constant; Inert atmosphere; |
C10H13NO2*C42H54N2O6*ClH
A
(6S,17S)-1,4-di[N-(S)-α-phenylethyl]-1,4-diaza-6,17-diphenoxymethyl-7,10,13,19-tetraoxacyclooctadecane
B
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
Conditions | Yield |
---|---|
In chloroform-d1; d(4)-methanol Equilibrium constant; Inert atmosphere; |
Z-Leu-OH
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
N-(benzyloxycarbonyl)-L-leucyl-L-phenylalanine methyl ester
Conditions | Yield |
---|---|
In ethyl acetate at 40℃; thermolysin, 0.05 M 2-(N-morpholino)ethanesulfonic acid - NaOH buffer pH 6.0 - 7.0, CaCl2; | 100% |
With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide In tetrahydrofuran at 0 - 20℃; for 21h; | 97% |
With N-ethylmorpholine;; isobutyl chloroformate In ethyl acetate 1.) 1 h, -30 deg C, 2.) 1 h, room temperature; | 65% |
t-Boc-L-valine
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
N-tert-butoxycarbonyl-L-valyl-L-phenylalanine methyl ester
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 24h; | 100% |
Stage #1: t-Boc-L-valine With 2,6-dimethylpyridine; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); 6-chloro-1-hydroxybenzotriazole In dichloromethane; N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: methyl (2S)-2-amino-3-phenylpropanoate hydrochloride With 2,6-dimethylpyridine In dichloromethane; N,N-dimethyl-formamide | 97% |
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; acetonitrile at 20℃; for 3h; | 89% |
N-(tert-butyloxycarbonyl)-L-isoleucine
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
(S)-methyl 2-((2S,3S)-2-((tert-butoxycarbonyl)amino)-3-methylpentanamido)-3-phenylpropanoate
Conditions | Yield |
---|---|
Stage #1: N-(tert-butyloxycarbonyl)-L-isoleucine With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate at 20℃; for 0.166667h; Stage #2: methyl (2S)-2-amino-3-phenylpropanoate hydrochloride at 20℃; for 1h; | 100% |
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In acetonitrile at 0 - 20℃; for 2h; | 98% |
Stage #1: methyl (2S)-2-amino-3-phenylpropanoate hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; Inert atmosphere; Stage #2: N-(tert-butyloxycarbonyl)-L-isoleucine With benzotriazol-1-ol In dichloromethane at 0℃; for 0.25h; Inert atmosphere; Stage #3: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 12h; Inert atmosphere; | 88% |
di-tert-butyl dicarbonate
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
(S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester
Conditions | Yield |
---|---|
With triethylamine In dichloromethane for 24h; Ambient temperature; | 100% |
With triethylamine In tetrahydrofuran at 0 - 20℃; Inert atmosphere; | 100% |
In tetrahydrofuran; methanol at 20℃; for 4h; Inert atmosphere; | 99% |
N-Cbz-L-Asp
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
N-benzyloxycarbonyl-L-aspartyl-L-phenylalanine methyl ester-L-phenylalanine methyl ester complex
Conditions | Yield |
---|---|
With sodium hydroxide In water at 40℃; for 20h; immobilized thermolysin, pH 6.5; | 100% |
BOC-ALA-HOBt
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
N-tert-butyloxycarbonylalanylphenylalanine methyl ester
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide for 0.5h; | 100% |
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
(R)-2-azido-3-phenylpropanoic acid
Conditions | Yield |
---|---|
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride | 100% |
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
(2S)-2-azido-3-phenylpropanoic acid
Conditions | Yield |
---|---|
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide 1.) 0 deg C, 2 h; 2.) room temp., 24 h; | 100% |
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
N-(tert-butoxycarbonyl)-2-methyl-L-proline
N-(tertbutyloxycarbonyl)-α-methyl-L-prolyl-L-phenylalanine methyl ester
Conditions | Yield |
---|---|
With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide In dichloromethane Ambient temperature; | 100% |
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
benzaldehyde
(S)-2-(benzylidene-amino)-3-phenyl-propionic acid methyl ester
Conditions | Yield |
---|---|
With magnesium sulfate; triethylamine In dichloromethane | 100% |
Stage #1: methyl (2S)-2-amino-3-phenylpropanoate hydrochloride With magnesium sulfate; triethylamine In dichloromethane at 20℃; for 0.25h; Inert atmosphere; Stage #2: benzaldehyde In dichloromethane at 20℃; Inert atmosphere; | 97% |
With triethylamine In chloroform at 0 - 20℃; for 24h; Inert atmosphere; Sealed tube; | 96% |
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
4-methoxy-benzaldehyde
methyl (E,S)-2-(4-methoxybenzylideneamino)-3-phenylpropionate
Conditions | Yield |
---|---|
With sodium carbonate In methanol for 12h; Ambient temperature; | 100% |
With 4 A molecular sieve; titanium tetrachloride; sodium sulfate; triethylamine In dichloromethane at 20℃; for 8h; | 94% |
With sodium hydrogencarbonate In methanol Reflux; | 87% |
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
N-Benzyloxycarbonyl-L-proline
N-carbobenzoxy-L-prolyl-L-phenylalanine methyl ester
Conditions | Yield |
---|---|
With N-Ethylmaleimide; benzotriazol-1-ol; dicyclohexyl-carbodiimide In tetrahydrofuran at 25℃; for 18h; pH 7.0-7.5; | 100% |
With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 19h; | 92% |
With triethylamine; 2-Pyridon-1-yl diphenyl phosphate In N,N-dimethyl-formamide for 3h; Ambient temperature; | 85% |
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane for 96h; Ambient temperature; | 100% |
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
chloroformic acid ethyl ester
methyl (S)-2-ethyloxycarbonylamino-3-phenylpropanoate
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In water at 0 - 20℃; | 100% |
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere; | 93% |
With triethylamine In tetrahydrofuran at 0 - 20℃; | 87% |
With sodium hydrogencarbonate for 4h; Ambient temperature; Yield given; |
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
N-[3β-hydroxy-lup-20(29)-en-28-oyl]-8-aminooctanoic acid
(S)-2-{8-[((1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-Acetoxy-1-isopropenyl-5a,5b,8,8,11a-pentamethyl-icosahydro-cyclopenta[a]chrysene-3a-carbonyl)-amino]-octanoylamino}-3-phenyl-propionic acid methyl ester
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane for 15h; Ambient temperature; | 100% |
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
5-[tert-butoxycarbonyl-(3,5-di-tert-butylbenzyl)-amino]pentanoic acid
2-{5-[tert-butoxycarbonyl(3,5-di-tert-butylbenzyl)amino]pentanoylamino}-3-phenylpropanoic acid methyl ester
Conditions | Yield |
---|---|
Stage #1: 5-[tert-butoxycarbonyl-(3,5-di-tert-butylbenzyl)-amino]pentanoic acid With 1,1'-carbonyldiimidazole In dichloromethane for 0.333333h; Stage #2: methyl (2S)-2-amino-3-phenylpropanoate hydrochloride With 1H-imidazole In dichloromethane at 20℃; | 100% |
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
(3S,4S)-1-(4-fluorobenzoyl)-3-triisopropylsiloxy-4-difluoromethylazetidin-2-one
Conditions | Yield |
---|---|
With 4-methyl-morpholine In dichloromethane at 25℃; for 12h; | 100% |
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
Boc-Trp-OH
Nα-(tert-butoxycarbonyl)-L-tryptophyl-L-phenylalanine methyl ester
Conditions | Yield |
---|---|
Stage #1: methyl (2S)-2-amino-3-phenylpropanoate hydrochloride With sodium carbonate In dichloromethane; water Stage #2: Boc-Trp-OH With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 2h; | 100% |
With O‑(6‑chlorobezotriazol‑1‑yl)‑N,N,N,N‑tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h; Inert atmosphere; | 99% |
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In acetonitrile at 0 - 20℃; for 2h; | 96% |
4-(1-carboxymethyl-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-ylmethyl)imidazole-1-carboxylic acid tert-butyl ester
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
4-{1-[(1-methoxycarbonyl-2-phenylethylcarbamoyl)methyl]-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-ylmethyl}-imidazole-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; | 100% |
di-tert-butyl dicarbonate
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
methyl (S)-2-[bis(tert-butoxycarbonyl) amino]-3-phenylpropanoate
Conditions | Yield |
---|---|
Stage #1: methyl (2S)-2-amino-3-phenylpropanoate hydrochloride With sodium carbonate In tetrahydrofuran; water at 20℃; for 2h; Stage #2: di-tert-butyl dicarbonate With dmap In acetonitrile at 20℃; for 12h; | 100% |
Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / water; tetrahydrofuran / 16 h / 22 °C / Inert atmosphere 2: dmap / acetonitrile / 16 h / 22 °C / Inert atmosphere View Scheme |
2-pyrazylcarboxylic acid
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
N-(2-pyrazinylcarbonyl)-L-phenylalanine methyl ester
Conditions | Yield |
---|---|
With 4-methyl-morpholine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In dichloromethane; acetonitrile at -15 - 25℃; for 5h; Product distribution / selectivity; | 100% |
With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide In tetrahydrofuran at 0℃; for 2.66667h; | 98% |
Stage #1: 2-pyrazylcarboxylic acid With benzotriazol-1-ol; dicyclohexyl-carbodiimide In tetrahydrofuran at 0℃; for 0.666667h; Stage #2: methyl (2S)-2-amino-3-phenylpropanoate hydrochloride With 4-methyl-morpholine In tetrahydrofuran for 12h; | 98% |
sodium acetate
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
(S)-N-acetylphenylalanine
Conditions | Yield |
---|---|
With C16H20N5O2(1+)*Cl(1-) In dichloromethane at 20℃; for 0.166667h; | 100% |
With 4-methyl-morpholine In methanol at 20℃; for 24h; | 90% |
(2S-trans)-3-butyl-oxirane carboxylic acid.dicyclohexylammonium salt
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
pivaloyl chloride
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran; ethyl acetate | 100% |
(R)-3-benzyloxycarbonyl-2-pentylpropanoic acid
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
N-[(R)-3-benzyloxycarbonyl-2-pentylpropanoyl]-L-phenylalanine methyl ester
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 2h; | 100% |
carbon monoxide
17-iodo-5α-androst-16-ene
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
C30H41NO3
Conditions | Yield |
---|---|
With palladium diacetate; triethylamine; triphenylphosphine at 100℃; for 8h; | 100% |
O-methyl-N-tert-butoxycarbonyl-L-tyrosine
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
Conditions | Yield |
---|---|
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane for 15h; | 100% |
Conditions | Yield |
---|---|
Stage #1: methyl (2S)-2-amino-3-phenylpropanoate hydrochloride With triethylamine In tetrahydrofuran for 0.0833333h; Stage #2: tert-butyl isothiocyanate In tetrahydrofuran for 1h; Heating / reflux; | 100% |
Molecular structure of Methyl L-phenylalaninate hydrochloride (CAS NO.7524-50-7) is:
Product Name: Methyl L-phenylalaninate hydrochloride
CAS Registry Number: 7524-50-7
IUPAC Name: methyl 2-amino-3-phenylpropanoate hydrochloride
Molecular Weight: 215.67666 [g/mol]
Molecular Formula: C10H14ClNO2
H-Bond Donor: 2
H-Bond Acceptor: 3
EINECS: 231-383-4
Melting Point: 158-162 °C(lit.)
Sensitive: Hygroscopic
Flash Point: 126 °C
Enthalpy of Vaporization: 50.2 kJ/mol
Boiling Point: 264.2 °C at 760 mmHg
Vapour Pressure: 0.00986 mmHg at 25°C
Product Categories: Protected Amino Acids;Amino Acids Series;Aminoacids Derivatives;Amino Acid Derivatives;Amino Acids;Phenylalanine [Phe, F];Amino Acids and Derivatives;Amino Acid Methyl Esters;Amino Acids (C-Protected);Biochemistry;Amino hydrochloride;Amino Acid Derivatives;Peptide Synthesis;Phenylalanine
Methyl L-phenylalaninate hydrochloride (CAS NO.7524-50-7) is used as pharmaceutical intermediates.
Safty information about Methyl L-phenylalaninate hydrochloride (CAS NO.7524-50-7) is:
Hazard Codes: Xi, C
Risk Statements: 36/37/38-34
R36/37/38:Irritating to eyes, respiratory system and skin.
R34:Causes burns.
Safety Statements: 24/25-45-36/37/39-27-26
S24/25:Avoid contact with skin and eyes.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S27:Take off immediately all contaminated clothing.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29224995
Methyl L-phenylalaninate hydrochloride , its cas register number is 7524-50-7. It also can be called L-Phenylalanine, methyl ester, hydrochloride ; Methyl (2S)-2-amino-3-phenylpropanoate hydrochloride ; L-Phenylalanine methyl ester hydrochloride .It is a white to off-white fine crystalline powder.
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