Methyl sulfone supplier | CasNO.67-71-0

Name
Dimethyl sulfone
EINECS 200-665-9
CAS No. 67-71-0
Article Data217
CAS DataBase
Density 1.139 g/cm³
Solubility 150 g/L (20 °C) in water
Melting Point 107-109 °C(lit.)
Formula C₂H₆O₂S
Boiling Point 240.9 °C at 760 mmHg
Molecular Weight 94.1344
Flash Point 132.7 °C
Transport Information
Appearance colourless crystals
Safety 22-24/25
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Methane,sulfonylbis- (9CI);Methyl sulfone (6CI,8CI);Dimethyl sulfone;Dimethylsulphone;Lignisul MSM;MSM;Methylsulfonylmethane;NSC 63345;Opti MSM;Opti-dimethyl sulfone;Dimethyl sulfone (MSM);
PSA 42.52000
LogP 0.74160

Synthetic route

: 75-18-3
dimethylsulfide

: 67-71-0
dimethylsulfone

Conditions

Conditions	Yield
With sodium periodate; ruthenium-carbon composite In water at 20℃; for 2h;	100%
With C4H9N2O9W In methanol; water at 20℃; for 1.16h; chemoselective reaction;	99%
With anthracene; oxygen; acetic acid In isopropyl alcohol at 75℃; for 2h; Temperature; Irradiation;	99%

: 67-68-5
dimethyl sulfoxide

: 67-71-0
dimethylsulfone

Conditions

Conditions	Yield
With sodium molybdate dihydrate; dihydrogen peroxide In methanol; water at 25℃; for 0.5h; Kinetics; Concentration;	100%
With iron(II) perchlorate monohydrate; ozone; acetonitrile	100%
With dihydrogen peroxide; [(η5-C5Me5)Mo(CO)3Cl] In acetonitrile at 35℃; for 2h;	99%

: 98-88-4
benzoyl chloride

: C8H10CuO2S(1-)*Br(1-)*Mg(2+)

A: 119-61-9
benzophenone

B: 67-71-0
dimethylsulfone

Conditions

Conditions	Yield
With ammonium chloride In tetrahydrofuran at -78℃; for 0.25h;	A 97% B n/a

...Expand

: 930-68-7
cyclohexenone

: lithium (methylsulfonyl)methyl(tert-butyl)cuprate

A: 67-71-0
dimethylsulfone

B: 936-99-2
3-tert-butylcyclohexanone

Conditions

Conditions	Yield
With ammonium chloride In tetrahydrofuran at 0℃;	A n/a B 96%

...Expand

: 106466-53-9
3-(4-chlorophenyl)-4-dimethylsulfiliminofurazan

A: 67-71-0
dimethylsulfone

B: 106446-22-4
3-(4-chlorophenyl)-4-nitrofurazan

Conditions

Conditions	Yield
With trifluoroacetyl peroxide In dichloromethane Heating;	A n/a B 96%

: 930-68-7
cyclohexenone

: CH3SO2CH2CuCH3(1-)*Li(1+)=(CH3SO2CH2CuCH3)Li

A: 67-71-0
dimethylsulfone

B: 591-24-2, 625-96-7
3-Methylcyclohexanone

Conditions

Conditions	Yield
With ammonium chloride In tetrahydrofuran at 0℃;	A n/a B 95%

...Expand

: 106466-53-9
3-(4-chlorophenyl)-4-dimethylsulfiliminofurazan

A: 67-71-0
dimethylsulfone

B: 106446-22-4
3-(4-chlorophenyl)-4-nitrofurazan

C: 3-(4-chlorophenyl)-4-dimethylsulfoximinofurazan

D: 106446-23-5
azoxy(4-chlorophenylfurazan)

Conditions

Conditions	Yield
With 4 A molecular sieve; 3,3-dimethyldioxirane In acetone for 16h; Ambient temperature;	A n/a B n/a C 87% D n/a

...Expand

: C95H88N4O4Pd

: 67-68-5
dimethyl sulfoxide

A: 67-71-0
dimethylsulfone

: C95H88N4O3Pd

Conditions

Conditions	Yield
In benzene at 20℃; for 6h;	A n/a B 82%

...Expand

: 286-28-2
cyclohexene sulfide

A: 21386-28-7
Tetramethyleethylenepisulfoxid

B: 67-71-0
dimethylsulfone

Conditions

Conditions	Yield
With oxygen; dimethyl sulfoxide at -40℃; Irradiation; methylene blue sensitizer;	A 79% B n/a

: 75-18-3
dimethylsulfide

A: 67-71-0
dimethylsulfone

B: 22230-82-6
((methyl-d3)sulfonyl)methane-d3

C: 67-68-5
dimethyl sulfoxide

Conditions

Conditions	Yield
With <18O,2H6>DMSO; oxygen; methylene blue In [D3]acetonitrile for 0.166667h; Mechanism; Product distribution; Irradiation;	A 7.4% B n/a C 77.5%

...Expand

: 67-68-5
dimethyl sulfoxide

A: rans-2-pinanol

B: 67-71-0
dimethylsulfone

Conditions

Conditions	Yield
With pinanyl hydroperoxide In various solvent(s) at 80℃; for 70h;	A 71.7% B 75.9%

: 119-61-9
benzophenone

: 89278-87-5
C8H9ClO2S

A: 67-71-0
dimethylsulfone

B: 106-48-9
4-chloro-phenol

Conditions

Conditions	Yield
for 5h; Product distribution;	A 73% B n/a

...Expand

: 3-(Dimethylsulfonio)-2,4-dioxo-1-oxaspiro<4.5>decan-3-id

A: 67-71-0
dimethylsulfone

B: 83527-51-9
1-Oxaspiro<4.5>decan-2,3,4-trion

C: 67-68-5
dimethyl sulfoxide

Conditions

Conditions	Yield
With ozone In dichloromethane at 0℃;	A n/a B 73% C n/a

...Expand

: 67-68-5
dimethyl sulfoxide

: 908093-98-1
diazodiphenylmethane

A: 119-61-9
benzophenone

B: 67-71-0
dimethylsulfone

Conditions

Conditions	Yield
With oxygen In acetonitrile at 25℃; Product distribution; Flash photolysis;	A 71% B 23.6%

...Expand

: 89278-87-5
C8H9ClO2S

: 100-52-7
benzaldehyde

A: 67-71-0
dimethylsulfone

B: 15436-11-0
(E)-methyl styryl sulfone

C: 89278-80-8
2-(p-Chlorophenoxy)-2-phenylethyl methyl sulfone

D: 89278-86-4
2-(Benzoyloxy)-2-phenylethyl methyl sulfone

E: 106-48-9
4-chloro-phenol

Conditions

Conditions	Yield
for 3h; Product distribution;	A 30% B 6% C 4.5% D 6.6% E 70%

...Expand

: 90344-86-8
3-chloro-2H-thiete 1,1-dioxide

: 67-71-0
dimethylsulfone

Conditions

Conditions	Yield
With sodium hydroxide for 0.166667h; Heating;	68%

: 74379-39-8
Bis-[2,6-bis-(difluoro-nitro-methyl)-2,6-bis-trifluoromethyl-3,6-dihydro-2H-[1,3,5]oxadiazin-4-yl]-amine; compound with methanesulfinylmethane

A: 75-18-3
dimethylsulfide

B: 67-71-0
dimethylsulfone

C: 74379-34-3
4,4'-iminobis<2,6-bis(difluoronitromethyl)-5,6-dihydro-2,6-bis(trifluoromethyl)-2H-1,3,5-oxadiazine>

Conditions

Conditions	Yield
With sulfuric acid at 50 - 60℃; for 2h;	A n/a B n/a C 67%

...Expand

: 76473-17-1
6-amino-1,3-dimethyl-5-<(p-nitrobenzylidene)amino>uracil

A: 1094-63-9
8-(p-Nitrophenyl)theophylline

B: 67-71-0
dimethylsulfone

Conditions

Conditions	Yield
With Ni-PO In dimethyl sulfoxide at 80℃; for 7.5h;	A 65% B n/a

: 89278-87-5
C8H9ClO2S

: 100-52-7
benzaldehyde

A: 67-71-0
dimethylsulfone

B: 15436-11-0
(E)-methyl styryl sulfone

C: 89278-80-8
2-(p-Chlorophenoxy)-2-phenylethyl methyl sulfone

D: 106-48-9
4-chloro-phenol

Conditions

Conditions	Yield
at -60℃; for 3h; Product distribution;	A 65% B 27.5% C 22% D n/a

...Expand

: 89278-87-5
C8H9ClO2S

: 98-53-3
4-tercbutyl-cyclohexanone

A: 67-71-0
dimethylsulfone

B: 89278-78-4
(4-tert-Butyl-1-cyclohexenyl)methyl methyl sulfone

C: 89278-77-3
<1-<(Methylsulfonyl)methyl>-1-(p-chlorophenoxy)-4-tert-butyl>cyclohexane

D: 106-48-9
4-chloro-phenol

Conditions

Conditions	Yield
at -60℃; for 3h; Product distribution;	A 64% B 42% C 3.7% D n/a

...Expand

: 110-05-4
di-tert-butyl peroxide

: 20277-69-4
sodium methansulfinate

: 67-71-0
dimethylsulfone

Conditions

Conditions	Yield
In water at 100℃; for 12h; Sealed tube;	61%
With water at 110℃; for 12h; Sealed tube; Green chemistry;	61%

: 67-71-0
dimethylsulfone

: C10H15N3O5

: C10H14ClN3O4

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 26h;	100%

: 30570-86-6
3-phenyl-1,3,4,5-tetrahydro-benzo[b]azepine-2-thione

: 67-71-0
dimethylsulfone

: 28717-73-9
2-methylsulfanyl-3-phenyl-4,5-dihydro-3H-benzo[b]azepine

Conditions

Conditions	Yield
In sodium hydroxide	99%

: 67-71-0
dimethylsulfone

: 52079-23-9
(3S)-3-hydroxydihydrofuran-2(3H)-one

: 1177369-50-4
methyl (S)-4-hydroxy-2-methoxybutyrate

Conditions

Conditions	Yield
Stage #1: (3S)-3-hydroxydihydrofuran-2(3H)-one With sodium hydride In tetrahydrofuran at 0℃; for 0.5h; Stage #2: dimethylsulfone In tetrahydrofuran at 20℃; Stage #3: potassium carbonate In methanol at 0℃; for 1h;	99%

: 864830-16-0
5-bromo-2-fluoro-4-methyl-pyridine

: 67-71-0
dimethylsulfone

: 5-bromo-4-methyl-2-((methylsulfonyl)methyl)pyridine

Conditions

Conditions	Yield
With sodium hexamethyldisilazane In tetrahydrofuran at -30 - 30℃;	98%

: 67-71-0
dimethylsulfone

: 117142-10-6, 50376-42-6
desoxydemethylenechicanine

: 54548-00-4
isoguaiacin dimethyl ether

Conditions

Conditions	Yield
With potassium carbonate In acetone	95%

: 67-71-0
dimethylsulfone

: 97966-31-9
3-ethoxy-4-methoxybenzoic acid methyl ester

: 1450657-28-9
1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-one

Conditions

Conditions	Yield
Stage #1: dimethylsulfone With sodium hydride In hexane at 15 - 35℃; Inert atmosphere; Stage #2: 3-ethoxy-4-methoxybenzoic acid methyl ester In hexane at 30 - 35℃; for 6h; Solvent; Temperature; Reagent/catalyst; Inert atmosphere;	95%
With potassium tert-butylate In dimethyl sulfoxide at 55℃; for 1.5h; Temperature; Inert atmosphere;	50%

: 67-71-0
dimethylsulfone

: 108947-14-4
3-Methyl-2-(methylpropionylamino)benzofuran-5-ol

: 108947-16-6
5-Methoxy-3-methyl-2-(methylpropionylamino)benzofuran

Conditions

Conditions	Yield
With potassium hydroxide In 1,4-dioxane; water Ambient temperature;	94%

: 67-71-0
dimethylsulfone

: 4780-79-4
1-naphthalene methanol

: 826-74-4
1-vinylnaphthalene

Conditions

Conditions	Yield
With platinum on carbon; potassium tert-butylate; hydrogen In toluene under 1875.19 Torr; for 15h; Inert atmosphere; Reflux;	94%
With C24H20ClN2OPRu; potassium tert-butylate In 1,4-dioxane at 125℃; for 5h; Inert atmosphere; Schlenk technique; Glovebox;	50%

: 67-71-0
dimethylsulfone

: 3597-91-9
biphenyl-4-yl methanol

: 2350-89-2
p-vinylbiphenyl

Conditions

Conditions	Yield
With platinum on carbon; potassium tert-butylate; hydrogen In toluene under 1875.19 Torr; for 12h; Catalytic behavior; Inert atmosphere; Reflux;	94%

: 67-71-0
dimethylsulfone

: 84592-24-5
2,7-dichloro-3,8-dihydroxy-1,4,9-trimethyl-11-oxo-11H-dibenzo<1,4>dioxepin-6-carbaldehyde

: 84608-39-9
2,7-dichloro-3,8-dimethoxy-1,4,9-trimethyl-11-oxo-11H-dibenzo<1,4>dioxepin-6-carbaldehyde

Conditions

Conditions	Yield
With potassium carbonate In acetone for 0.25h; Heating;	93%

: 67-71-0
dimethylsulfone

: C30H44N2O3S

: (1aS,3aR,3bS,5aR,6R,8aS,8bS,10R,10aR)-10-Methoxy-3a,5a-dimethyl-6-((R)-1-methyl-allyl)-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalene

Conditions

Conditions	Yield
Stage #1: dimethylsulfone With n-butyllithium In tetrahydrofuran; hexane for 0.25h; Metallation; Stage #2: C30H44N2O3S In tetrahydrofuran; hexane for 16h; Substitution;	93%

: 67-71-0
dimethylsulfone

: 279222-12-7
3α,5-cyclo-23,24-dinor-6β-methoxy-5α-cholane-24-al (E)-tosylhydrazone

: 54604-87-4
6β-methoxy-3α,5-cyclo-24-nor-5α-chol-22-ene

Conditions

Conditions	Yield
Stage #1: dimethylsulfone With n-butyllithium In tetrahydrofuran; hexane for 0.25h; Stage #2: 3α,5-cyclo-23,24-dinor-6β-methoxy-5α-cholane-24-al (E)-tosylhydrazone In tetrahydrofuran; hexane at 20℃; for 16h; Further stages.;	93%

: 67-71-0
dimethylsulfone

: 60758-86-3
3-ethoxy-4-methoxybenzenecarbonitrile

: 1450657-28-9
1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-one

Conditions

Conditions	Yield
Stage #1: dimethylsulfone With n-butyllithium In tetrahydrofuran; hexane Large scale; Stage #2: 3-ethoxy-4-methoxybenzenecarbonitrile In tetrahydrofuran; hexane at 0 - 5℃; Large scale; Stage #3: With hydrogenchloride; water In tetrahydrofuran; hexane Large scale;	93%
Stage #1: dimethylsulfone With n-butyllithium In tetrahydrofuran; hexane at 0 - 10℃; for 3h; Inert atmosphere; Stage #2: 3-ethoxy-4-methoxybenzenecarbonitrile In tetrahydrofuran at 0 - 20℃; for 6h;	81%
Stage #1: dimethylsulfone With n-butyllithium In tetrahydrofuran; hexane at 0 - 10℃; for 3h; Inert atmosphere; Industrial scale; Stage #2: 3-ethoxy-4-methoxybenzenecarbonitrile In tetrahydrofuran at 0 - 20℃; for 6h; Solvent; Concentration; Industrial scale;	81%

: 67-71-0
dimethylsulfone

: 87885-96-9
8-phenylindeno<1,2-c>isoxazol-7-one

: 87885-98-1
C18H15NO3S

Conditions

Conditions	Yield
at 85 - 90℃; for 312h; sealed flask;	92%

: 67-71-0
dimethylsulfone

: 1131-52-8
3-ethoxy-4-methoxybenzaldehyde

: 253168-94-4
2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine

Conditions

Conditions	Yield
Stage #1: dimethylsulfone With n-butyllithium In tetrahydrofuran; hexane at -20 - 0℃; for 1h; Stage #2: 3-ethoxy-4-methoxybenzaldehyde With lithium hexamethyldisilazane In tetrahydrofuran; hexane at -40 - -30℃; for 1h; Stage #3: With boron trifluoride diethyl etherate In tetrahydrofuran; hexane at -30 - 0℃; Temperature;	91.5%
Stage #1: 3-ethoxy-4-methoxybenzaldehyde With lithium hexamethyldisilazane at -78℃; Stage #2: dimethylsulfone With n-butyllithium; boron trifluoride diethyl etherate at -78℃;	41%

: 67-71-0
dimethylsulfone

: 75446-68-3
2-phenyl-4,5-tridecamethylenepyrazolone

: 75446-69-4
2-phenyl-1-methyl-4,5-tridecamethylenepyrazol-3-one

Conditions

Conditions	Yield
In toluene at 120℃; for 1.5h;	91%

Methyl sulfone Chemical Properties

Product Name: Methyl sulfone (CAS NO.67-71-0)

IUPAC Name: methylsulfonylmethane
Molecular Formula: C₂H₆O₂S
Molecular Weight: 94.132840 g/mol
Appearance: white crystalline flakes, great Stink
Density:1,16 g/cm³
Melting Point: 108-110 °C
Boiling Point: 238 °C
Flash Point: 143 °C
Solubility: water, ethanol, benzene, methanol and acetone, slightly soluble in ether and chloroform
Water Solubility: 150 g/L (20 °C)
Merck: 14,3258
BRN: 1737717
Index of Refraction: 1.402
Molar Refractivity: 20.11 cm³
Molar Volume: 82.5 cm³
Categories: Pharmaceutical Intermediates; Miscellaneous; Nutritional Supplements; Food & Flavor Additives

Methyl sulfone Uses

Methyl sulfone (CAS NO.67-71-0) is used as a high temp solvent for many inorganic and organic substances. It is also used as gas chromatography stationary phase and analytical reagent.

Methyl sulfone Safety Profile

Safety Information of Methyl sulfone (CAS NO.67-71-0):
Safety Statements:22-24/25
22:Do not breathe dust
24/25:Avoid contact with skin and eyes
WGK Germany:1
RTECS:PB2785000
HS Code:29309070

Methyl sulfone Specification

Methyl sulfone , its CAS NO. is 67-71-0, the synonyms are Dimethyl sulfone ; Dimethyl sulphone ; MSM ; Methyl sulfone ; Methylsulfonylmethane ; Sulfonylbismethane ; Dimethyl sulphone ; Methane, 1,1'-sulfonylbis- ; Methane, sulfonylbis- ; Methyl sulfone ; Methane, sulfonylbis- ; Methylsulfonyl methane ; Sulfonylbismethane .

Product Name

Dimethyl sulfone

Synthetic route

Methyl sulfone Chemical Properties

Methyl sulfone Uses

Methyl sulfone Safety Profile

Methyl sulfone Specification

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