5-(P-benzyloxyphenyl) hydantoin
(D)-p-benzyloxyphenylglycine
N-(hydroxyphenyl)glycine
Conditions | Yield |
---|---|
With acetic acid; Pd-C In conc. NaOH; hydrogen | 92% |
DL-p-hydroxyphenylglycine methyl ester
N-(hydroxyphenyl)glycine
Conditions | Yield |
---|---|
76% |
4-hydroxyphenyl-glycine ethyl ester
N-(hydroxyphenyl)glycine
Conditions | Yield |
---|---|
With hydrogenchloride | 66.5% |
Conditions | Yield |
---|---|
With ammonium acetate In water | 50.4% |
Conditions | Yield |
---|---|
With ammonium acetate In water | 33.6% |
Conditions | Yield |
---|---|
With ammonium acetate In water | 28.9% |
2-((4-hydroxyphenyl)amino)acetonitrile
N-(hydroxyphenyl)glycine
Conditions | Yield |
---|---|
With sodium hydroxide |
Conditions | Yield |
---|---|
With water at 85 - 90℃; |
Conditions | Yield |
---|---|
With water | |
With water; sodium acetate |
4-amino-phenol
chloroacetic acid
A
N-(hydroxyphenyl)glycine
B
(4-hydroxy-phenylimino)-di-acetic acid
Conditions | Yield |
---|---|
With sodium hydroxide |
ethanol
4-amino-phenol
A
N-(hydroxyphenyl)glycine
B
N-(4-hydroxy-phenyl)-glycine-(4-hydroxy-anilide)
Conditions | Yield |
---|---|
With water |
4-amino-phenol
A
N-(hydroxyphenyl)glycine
B
N-(4-hydroxy-phenyl)-glycine-(4-hydroxy-anilide)
Conditions | Yield |
---|---|
With ethanol |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: NaHSO3 / 20 °C 2: diluted NaOH-solution View Scheme |
N-(hydroxyphenyl)glycine
Conditions | Yield |
---|---|
In water |
N-(hydroxyphenyl)glycine
Conditions | Yield |
---|---|
With ammonia In hydrogenchloride; dichloromethane; water |
N-(hydroxyphenyl)glycine
Conditions | Yield |
---|---|
In hydrogenchloride |
N-(hydroxyphenyl)glycine
DL-p-hydroxyphenylglycine methyl ester
Conditions | Yield |
---|---|
In methanol; HCl (gas) | 99% |
With thionyl chloride In methanol |
methanol
N-(hydroxyphenyl)glycine
DL-p-hydroxyphenylglycine methyl ester
Conditions | Yield |
---|---|
With 732 strong acid resin at 65 - 70℃; Reagent/catalyst; | 96.1% |
With hydrogenchloride |
sulfuric acid
N-(hydroxyphenyl)glycine
DL-p-hydroxyphenylglycine methyl ester
Conditions | Yield |
---|---|
With ammonium hydroxide In methanol | 89.5% |
di-tert-butyl dicarbonate
N-(hydroxyphenyl)glycine
sodium hydrogencarbonate
(R)-N-(tert-butoxycarbonyl)-4-hydroxyphenylglycine methyl ester
Conditions | Yield |
---|---|
With thionyl chloride In methanol; ethyl acetate | 87% |
di-tert-butyl dicarbonate
N-(hydroxyphenyl)glycine
N-t-butoxycarbonyl-p-hydroxyphenylglycine
Conditions | Yield |
---|---|
With triethylamine In methanol; water; ethyl acetate; benzene | 86% |
N-(hydroxyphenyl)glycine
4-cyanomethylphenol
Conditions | Yield |
---|---|
With sodium hydroxide In water; N,N-dimethyl-formamide | 80% |
N-(hydroxyphenyl)glycine
isatin-5-monosulphonic acid
4-hydroxy-benzaldehyde
Conditions | Yield |
---|---|
With acetic acid In water | 79.4% |
Conditions | Yield |
---|---|
In 1-methyl-pyrrolidin-2-one; water | 75% |
Conditions | Yield |
---|---|
In water; acetic acid | 68% |
N-(hydroxyphenyl)glycine
water
iron(III) chloride
salicylaldehyde
sodium hydroxide
Conditions | Yield |
---|---|
In methanol; ethanol; water 2-(4-hydroxyphenyl)aminoacetic acid, NaOH and salicylaldehyde dissolved in MeOH; heated with stirring for 2 h; cooled to room temp.; EtOH soln. of FeCl3 added with stirring; stirred for 0.5 h; NaOH in distd. H2O added; stirred for 0.5 h; filtered; crystd. from filtrate by slow evapn. at room temp. for 1 wk; elem. anal.; | 63% |
Conditions | Yield |
---|---|
In water | 62% |
N-(hydroxyphenyl)glycine
water
iron(III) chloride
salicylaldehyde
sodium hydroxide
Conditions | Yield |
---|---|
In methanol; ethanol; water HOC6H4NH2CH2COOH, NaOH and HOC6H4CHO in MeOH heated with stirring (2 h);cooled to room temp.; EtOH soln. of FeCl3 added with stirring; stirred (0.5 h); aq. NaOH added; stirred (0.5 h); filtered; crystd. from filtrat e; more NaOH and HOC6H4CHO added; crystd. for 1 wk; elem. anal.; | 45% |
Conditions | Yield |
---|---|
In water | 37.2% |
tridecanal
N-(hydroxyphenyl)glycine
fullerene-C60
Conditions | Yield |
---|---|
In chlorobenzene for 3h; Reflux; | 35.1% |
thiophene-2-carbaldehyde
N-(hydroxyphenyl)glycine
fullerene-C60
Conditions | Yield |
---|---|
In chlorobenzene for 3h; Reflux; | 34.8% |
caprinaldehyde
N-(hydroxyphenyl)glycine
fullerene-C60
Conditions | Yield |
---|---|
In chlorobenzene for 3h; Reflux; | 33.6% |
N-(hydroxyphenyl)glycine
fullerene-C60
isobutyraldehyde
Conditions | Yield |
---|---|
In chlorobenzene for 3h; Reflux; | 33.4% |
formaldehyd
N-(hydroxyphenyl)glycine
fullerene-C60
Conditions | Yield |
---|---|
In toluene Heating; | 33% |
N-(hydroxyphenyl)glycine
butyraldehyde
fullerene-C60
Conditions | Yield |
---|---|
In chlorobenzene for 3h; Reflux; | 32.3% |
N-(hydroxyphenyl)glycine
3,4-dimethoxy-benzaldehyde
fullerene-C60
Conditions | Yield |
---|---|
In chlorobenzene for 3h; Reflux; | 32% |
2,2'-bithiophene-5-carboxaldehyde
N-(hydroxyphenyl)glycine
fullerene-C60
Conditions | Yield |
---|---|
In chlorobenzene for 3h; Reflux; | 31.6% |
heptanal
N-(hydroxyphenyl)glycine
fullerene-C60
Conditions | Yield |
---|---|
In chlorobenzene for 3h; Reflux; | 30.9% |
This chemical is called N-(4-Hydroxyphenyl)glycine, and it can also be named as Glycin. The CAS registry number of this chemical is 122-87-2, and its product categories are Glycine Derivatives; Peptide Synthesis; Unnatural Amino Acid Derivatives. This chemical is typically characterized as thin plates of white or silvery powder when it's fresh. It is sparingly soluble in water and most organic solvents. The N-(4-Hydroxyphenyl)glycine is rarely used as a developing agent today, because it is expensive and its manufactured for specialty applications only.
Other characteristics of the N-(4-Hydroxyphenyl)glycine can be summarised as followings: (1)ACD/LogP: -0.13; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.37; (4)ACD/LogD (pH 7.4): -3.12; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1.16; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 4; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 4; (12)Polar Surface Area: 38.77 Å2; (13)Index of Refraction: 1.664; (14)Molar Refractivity: 43.94 cm3; (15)Molar Volume: 118.4 cm3; (16)Polarizability: 17.41×10-24cm3; (17)Surface Tension: 70.1 dyne/cm; (18)Density: 1.411 g/cm3; (19)Flash Point: 223.7 °C; (20)Enthalpy of Vaporization: 74.24 kJ/mol; (21)Boiling Point: 446.3 °C at 760 mmHg; (22)Vapour Pressure: 9.49E-09 mmHg at 25°C.
When you are using this chemical, please be cautious about it as the following: This chemical is irritating to eyes, respiratory system and skin, so you should wear suitable protective clothing when you use it. In case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.
You can still convert the following datas into molecular structure:
1.SMILES: O=C(O)CNc1ccc(O)cc1
2.InChI: InChI=1/C8H9NO3/c10-7-3-1-6(2-4-7)9-5-8(11)12/h1-4,9-10H,5H2,(H,11,12)
3.InChIKey: WRUZLCLJULHLEY-UHFFFAOYAB
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