N-Benzylhydroxylamine supplier

Name
N-BENZYLHYDROXYLAMINE HYDROCHLORIDE
EINECS
CAS No. 622-30-0
Article Data85
CAS DataBase
Density 1.098g/cm³
Solubility
Melting Point ~105 °C
Formula C₇H₉NO
Boiling Point 253.9 °C at 760 mmHg
Molecular Weight 123.155
Flash Point 135.2 °C
Transport Information
Appearance
Safety 26-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Hydroxylamine,N-benzyl- (6CI,7CI,8CI);Benzylhydroxylamine;N-Benzylhydroxylamine;N-Hydroxybenzylamine;O-Benzylhydroxyamine;
PSA 32.26000
LogP 1.55630

Synthetic route

: 932-90-1
Benzaldoxime

: 622-30-0
N-benzyl hydroxylalmine

Conditions

Conditions	Yield
With K12(Ga4(1,5-bis(2,3-dihydroxybenzamido)naphthalene))6; potassium phosphate; borane pyridine In water-d2 at 20℃; for 22h; Reagent/catalyst; Inert atmosphere; Sealed tube;	100%
With Benzyltriethylammonium borohydride for 0.133333h; solid-phase conditions;	95%
With sodium cyanoborohydride at 20℃;	80%

: 29601-98-7
N-benzylhydroxylamine hydrochloride

: 622-30-0
N-benzyl hydroxylalmine

Conditions

Conditions	Yield
With sodium hydrogencarbonate In water	100%
With sodium hydrogencarbonate In methanol for 0.25h;
With 4-methyl-morpholine In dichloromethane Schlenk technique; Inert atmosphere;

: 932-90-1, 622-31-1, 140461-24-1, 140461-25-2, 622-32-2
syn-benzaldehyde oxime

: 622-30-0
N-benzyl hydroxylalmine

Conditions

Conditions	Yield
With sodium cyanoborohydride; acetyl chloride In methanol at 0℃;	94%
With hydrogenchloride; sodium cyanoborohydride In methanol at 25℃; for 4h;	87%
With hydrogenchloride; sodium cyanoborohydride In methanol pH=3;	61%
With hydrogenchloride; sodium cyanoborohydride In methanol at 20℃; for 3h;	49%

: 622-32-2
(Z)-benzaldehyde oxime

: 622-30-0
N-benzyl hydroxylalmine

Conditions

Conditions	Yield
With hydrogenchloride; sodium cyanoborohydride In methanol at 25℃; for 3.5h; Reduction;	94%

: 100-46-9
benzylamine

A: 622-30-0
N-benzyl hydroxylalmine

B: 932-90-1
Benzaldoxime

Conditions

Conditions	Yield
With 4a-FlEt-OOH In 1,4-dioxane at 30℃; Rate constant;	A n/a B 90%

: 113768-51-7
ethyl 2-benzyl-2,5-dihydro-3-methyl-5-oxoisoxazole-4-carboxylate

: 622-30-0
N-benzyl hydroxylalmine

Conditions

Conditions	Yield
With hydrogenchloride; acetic acid In water	81%

: 3376-26-9
N-Benzylidenebenzylamine N-oxide

: 622-30-0
N-benzyl hydroxylalmine

Conditions

Conditions	Yield
With hydrogenchloride steam destillation;	79%
With sulfuric acid In water for 4h; Heating;	71%
With hydrogenchloride In water for 1h; Reflux;

: 100-39-0
benzyl bromide

: 622-30-0
N-benzyl hydroxylalmine

Conditions

Conditions	Yield
With hydroxylamine monohydrate In methanol at 100℃; under 18100.7 Torr; for 0.166667h; Flow reactor; chemoselective reaction;	76%

: 100-44-7
benzyl chloride

: 622-30-0
N-benzyl hydroxylalmine

Conditions

Conditions	Yield
With hydroxylamine monohydrate In methanol at 100℃; under 18100.7 Torr; for 0.166667h; Flow reactor; chemoselective reaction;	65%
With hydroxylamine hydrochloride; triethylamine In water; dimethyl sulfoxide at 100℃; for 1h;	38%

: 104701-87-3
(2S)-3-(tert-butyl-dimethyl-silyloxy)-2-methyl-propanal

A: 622-30-0
N-benzyl hydroxylalmine

B: 112057-68-8, 299179-53-6
(R)-(-)-N-(3-t-butyldimethylsilyloxy-2-methylpropylidene)benzylamine N-oxide

Conditions

Conditions	Yield
With calcium chloride In argon	A n/a B 64%

: 122744-71-2
trans-Dihydro-3-phenyl-5-(phenylmethyl)-6-heptyl-1,2,4,5-trioxazine

A: 124-13-0
Octanal

B: 16204-37-8
3,6-diphenyl-1,2,4,5-tetraoxane

C: 72552-76-2
α-Heptyl-N-benzylnitrone

D: 100-52-7
benzaldehyde

E: 622-30-0
N-benzyl hydroxylalmine

F: 65-85-0
benzoic acid

Conditions

Conditions	Yield
With trifluoroacetic acid In dichloromethane for 15h; Product distribution; Ambient temperature;	A 26% B 11% C 25% D 30% E 25% F 16%

...Expand

: 4383-24-8
N,O-dibenzylhydroxylamine

A: 100-44-7
benzyl chloride

B: 622-30-0
N-benzyl hydroxylalmine

Conditions

Conditions	Yield
With hydrogenchloride at 130℃; im geschlossenen Rohr;

: 38636-02-1
N-benzyl-O-benzoylhydroxylamine

: 141-52-6
sodium ethanolate

A: 622-30-0
N-benzyl hydroxylalmine

B: 65-85-0
benzoic acid

...Expand

: 3376-26-9
N-Benzylidenebenzylamine N-oxide

A: 622-30-0
N-benzyl hydroxylalmine

B: 588-64-7
benzaldehyde phenylhydrazone

Conditions

Conditions	Yield
With phenylhydrazine at 80℃;

: 3376-29-2
N-benzyl-1,1-diphenylmethanimine oxide

: 622-30-0
N-benzyl hydroxylalmine

Conditions

Conditions	Yield
With hydrogenchloride

: 3376-29-2
N-benzyl-1,1-diphenylmethanimine oxide

A: 119-61-9
benzophenone

B: 622-30-0
N-benzyl hydroxylalmine

Conditions

Conditions	Yield
Hydrolyse;

: 112408-47-6
N,N,O-tribenzylhydroxylamine

: 622-30-0
N-benzyl hydroxylalmine

Conditions

Conditions	Yield
bei der Destillation im Vakuum;

: 100-44-7
benzyl chloride

: 64-19-7
acetic acid

: 127-06-0
acetone oxime

: 622-30-0
N-benzyl hydroxylalmine

...Expand

: 100-44-7
benzyl chloride

: 621-07-8
N,N-dibenzylhydroxylamine

A: 620-40-6
tribenzylamine

B: 622-30-0
N-benzyl hydroxylalmine

C: 100-46-9
benzylamine

D: 103-49-1
dibenzylamine

...Expand

: 3376-26-9
N-Benzylidenebenzylamine N-oxide

: 100-63-0
phenylhydrazine

A: 622-30-0
N-benzyl hydroxylalmine

B: 588-64-7
benzaldehyde phenylhydrazone

...Expand

: 38636-02-1
N-benzyl-O-benzoylhydroxylamine

: 622-30-0
N-benzyl hydroxylalmine

Conditions

Conditions	Yield
With sodium hydroxide In methanol

: 52245-12-2
N-Benzyl-4-methyl-N-(2,4,6-trimethyl-benzyloxy)-benzenesulfonamide

: 622-30-0
N-benzyl hydroxylalmine

Conditions

Conditions	Yield
With hydrogen bromide In acetic acid

: 5815-55-4
N,N-Dibenzyl-O-ethyl-hydroxylamin

: 622-30-0
N-benzyl hydroxylalmine

Conditions

Conditions	Yield
With peracetic acid In acetonitrile

: 100-39-0
benzyl bromide

A: 622-33-3
N-benzyloxyamine

B: 622-30-0
N-benzyl hydroxylalmine

C: 621-07-8
N,N-dibenzylhydroxylamine

Conditions

Conditions	Yield
With hydroxylamine hydrochloride; potassium tert-butylate In tert-butyl alcohol for 1.33333h; Ambient temperature; Yield given. Yields of byproduct given;

...Expand

: 146085-62-3
N-benzyl-O-(p-methylbenzyl)hydroxylamine

A: 100-52-7
benzaldehyde

B: 104-82-5
4-Methylbenzyl chloride

C: 622-30-0
N-benzyl hydroxylalmine

Conditions

Conditions	Yield
With hydrogenchloride for 5h; Heating;	A 0.3 mmol B 2.4 mmol C 0.2 g

...Expand

: 7339-99-3
N-benzylbenzohydroxamic acid

A: 622-30-0
N-benzyl hydroxylalmine

B: 65-85-0
benzoic acid

Conditions

Conditions	Yield
With hydrogenchloride In 1,4-dioxane at 55℃; Rate constant; Thermodynamic data; Mechanism; var. conc. HCl; ΔH(excit.), ΔS(excit.), ΔG(excit.);
With hydrogenchloride; cetyltrimethylammonim bromide In 1,4-dioxane Kinetics; Activation energy; Further Variations:; Reagents; Hydrolysis;

: 85407-77-8
N-Benzyl-p-fluorobenzohydroxamic acid

A: 456-22-4
4-Fluorobenzoic acid

B: 622-30-0
N-benzyl hydroxylalmine

Conditions

Conditions	Yield
With hydrogenchloride In 1,4-dioxane at 55℃; Rate constant; Thermodynamic data; Mechanism; var. conc. HCl; ΔH(excit.), ΔS(excit.), ΔG(excit.);

: N-Benzyl-N-hydroxy-4-methyl-benzamide

A: 99-94-5
p-Toluic acid

B: 622-30-0
N-benzyl hydroxylalmine

Conditions

Conditions	Yield
With hydrogenchloride In 1,4-dioxane at 55℃; Rate constant; Thermodynamic data; Mechanism; var. conc. HCl; ΔH(excit.), ΔS(excit.), ΔG(excit.);

: 75-07-0
acetaldehyde

: 622-30-0
N-benzyl hydroxylalmine

: 243140-08-1
5(Z)-N-ethylidene-1-phenylmethanamine N-oxide

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 1h;	100%
With sodium sulfate In dichloromethane Ambient temperature;	55%

: 75-07-0
acetaldehyde

: 622-30-0
N-benzyl hydroxylalmine

: 20135-15-3, 243140-08-1, 139189-66-5
N-ethylidenebenzylamine N-oxide

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane at 20℃; for 1h; Inert atmosphere;	100%
With magnesium sulfate In dichloromethane at 20℃; for 1h; Inert atmosphere;	100%
With magnesium sulfate In dichloromethane at 20℃; for 1h; Inert atmosphere;	100%

: 20498-05-9
3-allylcyclohexanone

: 622-30-0
N-benzyl hydroxylalmine

: 86437-24-3, 104265-41-0
(1S,5R,7R)-2-Benzyl-3-oxa-2-aza-tricyclo[5.3.1.01,5]undecane

Conditions

Conditions	Yield
at 80℃; for 3h; aromatic solvent;	100%
In methanol; benzene for 3h; Heating; azeotropic water removal;	100%

: 622-30-0
N-benzyl hydroxylalmine

: 15186-48-8
2,3-isopropylidene-glyceraldehyde

: 91190-38-4, 111058-38-9, 1165677-00-8
N-benzyl-2,3-O-isopropylidene-D-glyceraldehyde nitrone

Conditions

Conditions	Yield
With sodium sulfate In dichloromethane at 20℃; for 16.5h; Inert atmosphere;	100%
With magnesium sulfate In dichloromethane for 2h;	95%
With magnesium sulfate In dichloromethane at 20℃; Condensation;	94%

: 622-30-0
N-benzyl hydroxylalmine

: 107-13-1
acrylonitrile

: 3-(benzyl(hydroxy)amino)propanenitrile

Conditions

Conditions	Yield
In chloroform-d1 at 20℃; for 0.166667h;	100%

: 622-30-0
N-benzyl hydroxylalmine

: 78-84-2
isobutyraldehyde

: 105623-17-4, 115869-93-7
(Z)-N-(2-methylpropylidene)benzylamine N-oxide

Conditions

Conditions	Yield
In diethyl ether at 20℃; for 1h;	99%
With magnesium sulfate In diethyl ether for 15h;	84%
With magnesium sulfate In dichloromethane for 4h; Ambient temperature;	83%
With magnesium sulfate In diethyl ether for 15h; Addition;	78%
With magnesium sulfate In diethyl ether at 20℃; for 15h; Inert atmosphere;	65%

: 2386-64-3
ethylmagnesium chloride

: 622-30-0
N-benzyl hydroxylalmine

: 111612-92-1, 138515-69-2
(4S,5S)-(Z)-N-(2,2,5-trimethyl-1,3-dioxolan-4-yl)methylenebenzylamine N-oxide

Conditions

Conditions	Yield
for 20h;	99%

: 60656-87-3
benzyloxyacetoaldehyde

: 622-30-0
N-benzyl hydroxylalmine

: 192220-12-5, 199463-78-0
(Z)-N-[2-(benzyloxy)ethylidene]benzylamine N-oxide

Conditions

Conditions	Yield
In dichloromethane for 12h; Ambient temperature;	99%
In dichloromethane at 20℃;	97%

: 16212-06-9
phenyl styryl sulfone

: 622-30-0
N-benzyl hydroxylalmine

: N-(2-benzenesulfonyl-1-phenyl-ethyl)-N-benzyl-hydroxylamine

Conditions

Conditions	Yield
In ethanol for 12h;	99%

: 123-11-5
4-methoxy-benzaldehyde

: 622-30-0
N-benzyl hydroxylalmine

: 32114-41-3, 115175-98-9
N-benzyl-α-(4-methoxyphenyl)nitrone

Conditions

Conditions	Yield
In toluene at 20℃; for 12h; Molecular sieve;	99%
In dichloromethane for 24h; Heating;	80%
With magnesium sulfate In dichloromethane at 20℃;	55%

: 622-30-0
N-benzyl hydroxylalmine

: 2043-61-0
cyclohexanecarbaldehyde

: 22687-06-5, 309918-57-8
(Z)-N-(cyclohexylmethylene)-1-phenylmethanamine oxide

Conditions

Conditions	Yield
With magnesium sulfate In toluene at 20℃; for 16.5h; Inert atmosphere;	99%
With magnesium sulfate In diethyl ether for 18h;	88%
With magnesium sulfate In dichloromethane at 20℃;	56%
at 20℃;

: 100-52-7
benzaldehyde

: 622-30-0
N-benzyl hydroxylalmine

: 77681-22-2, 3376-26-9, 85225-56-5
(Z)-N-benzylidenebenzylamine N-oxide

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane at 20℃; for 15h; Inert atmosphere;	99%
With magnesium sulfate In dichloromethane for 15h; Addition;	92%
With magnesium sulfate In dichloromethane for 24h;	92%

: 66-99-9
β-naphthaldehyde

: 622-30-0
N-benzyl hydroxylalmine

: 22661-26-3
C-(2-naphthyl)-N-benzylnitrone

Conditions

Conditions	Yield
for 0.0666667h; Ionic liquid; Microwave irradiation;	99%
Inert atmosphere;

: 60656-87-3
benzyloxyacetoaldehyde

: 622-30-0
N-benzyl hydroxylalmine

: 192220-12-5, 199463-78-0
(C-benzyloxymethane-N-benzyl)nitrone

Conditions

Conditions	Yield
In chloroform for 3h;	99%

: 104-88-1
4-chlorobenzaldehyde

: 622-30-0
N-benzyl hydroxylalmine

: 22687-09-8
4-chloro-benzaldehyde-(N-benzyl oxime )

Conditions

Conditions	Yield
With pyrrolidine In dichloromethane at 20℃; for 0.05h;	99%
Inert atmosphere;

: 622-30-0
N-benzyl hydroxylalmine

: 98-80-6
phenylboronic acid

: 758640-21-0
N-Benzylaniline

Conditions

Conditions	Yield
With trichloroacetonitrile In tert-butyl alcohol at 28℃; Solvent;	99%

: 1765-93-1
4-fluoroboronic acid

: 622-30-0
N-benzyl hydroxylalmine

: 370-77-4
N-benzyl-p-fluoroaniline

Conditions

Conditions	Yield
With trichloroacetonitrile In tert-butyl alcohol at 28℃;	99%

: 17933-03-8
m-tolylboronic acid

: 622-30-0
N-benzyl hydroxylalmine

: 5405-17-4
N-benzyl-3-methylaniline

Conditions

Conditions	Yield
With trichloroacetonitrile In tert-butyl alcohol at 28℃;	99%

: 5720-05-8
4-methylphenylboronic acid

: 622-30-0
N-benzyl hydroxylalmine

: 5405-15-2
N-benzyl-N-(4-methylphenyl)amine

Conditions

Conditions	Yield
With trichloroacetonitrile In tert-butyl alcohol at 28℃;	99%

: 100124-06-9
4-dibenzofurylboronic acid

: 622-30-0
N-benzyl hydroxylalmine

: N-benzyldibenzo[b,d]furan-4-amine

Conditions

Conditions	Yield
With trichloroacetonitrile In tert-butyl alcohol at 28℃;	99%

: 50-00-0
formaldehyd

: 622-30-0
N-benzyl hydroxylalmine

: 74635-18-0
N-benzylmethylene nitrone

Conditions

Conditions	Yield
In ethanol for 1h;	98%
With diethyl ether

: 622-30-0
N-benzyl hydroxylalmine

: 67-64-1
acetone

: 159330-32-2
N-(1-methylethylidene)benzylamine N-oxide

Conditions

Conditions	Yield
With magnesium sulfate; zinc(II) chloride In dichloromethane for 0.0833333h; Ambient temperature;	98%
for 1.5h; Heating;

: 126983-27-5
(R)-(E)-but-2-enoic acid 4,4-dimethyl-2-oxotetrahydrofuran-3-yl ester

: 622-30-0
N-benzyl hydroxylalmine

: 95503-62-1
N-Benzyl-3-methylisoxazolidin-5-one

Conditions

Conditions	Yield
In tetrahydrofuran at 22℃; for 25h;	98%

: 622-30-0
N-benzyl hydroxylalmine

: 158092-04-7
4-Phenyl-3-oxahept-6-enal

: 158091-86-2
C19H21NO2

Conditions

Conditions	Yield
With magnesium sulfate In diethyl ether at 0℃; for 1h; Condensation;	98%

: 622-30-0
N-benzyl hydroxylalmine

: 55385-72-3
(3aS,3bR,7aS,8aR)-2,2,5,5-tetramethyltetrahydro-8aH-[1,3]dioxolo[4′,5′:4,5]furo[3,2-d][1,3]dioxine-8a-carbaldehyde

: 315203-56-6
N-(1-deoxo-2,3:4,6-di-O-isoprpylidene-α-L-xylo-hex-2-ul-1-ylidene)benzylamine N-oxide

Conditions

Conditions	Yield
In diethyl ether at 0℃; for 1h; Condensation;	98%

: 1111158-63-4
(4R)-3-benzyl-2-oxo-oxazolidine-4-carbaldehyde

: 622-30-0
N-benzyl hydroxylalmine

: 1111158-64-5
(4S)-3-benzyl-2-oxo-1,3-oxazolidine-4-methylidenbenzylamine-N-oxide

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane at 20℃; for 3h; Inert atmosphere;	98%

: 627-37-2
N-methyl-N-allylamine

: 622-30-0
N-benzyl hydroxylalmine

: N2-benzyl-N2-hydroxy-N1-methylpropane-1,2-diamine

Conditions

Conditions	Yield
With formaldehyd In tert-butyl alcohol at 30℃; for 24h; Reagent/catalyst; Solvent; Temperature; Time; Inert atmosphere;	98%
In neat (no solvent) at 80℃; for 6h; Inert atmosphere; regioselective reaction;	92%
With benzyloxyacetoaldehyde In benzene at 20℃; for 24h; Inert atmosphere;	72%

N-Benzylhydroxylamine Specification

The N-Benzylhydroxylamine, with the cas registry number 622-30-0, has the systematic name of N-hydroxy-1-phenylmethanamine. It belongs to the category of Polyamines. And the molecular formula of the chemical is C₇H₉NO.

The characteristics of this chemical are as followings: (1)ACD/LogP: 1.30; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.22; (4)ACD/LogD (pH 7.4): 1.3; (5)ACD/BCF (pH 5.5): 4.76; (6)ACD/BCF (pH 7.4): 5.73; (7)ACD/KOC (pH 5.5): 100.69; (8)ACD/KOC (pH 7.4): 121.38; (9)#H bond acceptors: 2; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 3; (12)Polar Surface Area: 12.47Å²; (13)Index of Refraction: 1.561; (14)Molar Refractivity: 36.29 cm³; (15)Molar Volume: 112 cm³; (16)Polarizability: 14.39×10^-24cm³; (17)Surface Tension: 44 dyne/cm; (18)Density: 1.098 g/cm³; (19)Flash Point: 135.2 °C ; (20)Enthalpy of Vaporization: 51.91 kJ/mol; (21)Boiling Point: 253.9 °C at 760 mmHg; (22)Vapour Pressure: 0.00923 mmHg at 25°C.

You should be cautious while dealing with this chemical. It irritates to the skin eyes and respiratory system. Therefore, you had better take the following instructions: Wear suitable gloves and eye/face protection, and if in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

Addtionally, the following datas could be converted into the molecular structure:
(1)SMILES: ONCc1ccccc1
(2)InChI: InChI=1/C7H9NO/c9-8-6-7-4-2-1-3-5-7/h1-5,8-9H,6H2
(3)InChIKey: LVCDXCQFSONNDO-UHFFFAOYAD

Product Name

N-BENZYLHYDROXYLAMINE HYDROCHLORIDE

Synthetic route

N-Benzylhydroxylamine Specification

Related Products

Hot Products