Nonaethylene glycol monomethyl ether supplier

Name
NONAETHYLENE GLYCOL MONOMETHYL ETHER
EINECS
CAS No. 6048-68-6
Article Data12
CAS DataBase
Density 1.079g/cm³
Solubility
Melting Point 14 °C
Formula C₁₉H₄₀O₁₀
Boiling Point 490.1 °C at 760 mmHg
Molecular Weight 428.521
Flash Point 250.2 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol(6CI,8CI,9CI);Ethanol, 2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-;Methoxynonaethylene glycol;Nonaethylene glycol, monomethyl ether;
PSA 103.30000
LogP -0.24210

Synthetic route

: 211859-58-4
1-Phenyl-2,5,8,11,14,17,20,23,26,29-decaoxatriacontane

: 6048-68-6
2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol

Conditions

Conditions	Yield
With hydrogen; palladium 10% on activated carbon In tetrahydrofuran for 1.08333h;	97%
With hydrogen; palladium 10% on activated carbon In methanol under 2.58551 Torr;	74%

: 2615-15-8
pentaethylene glycol

: 62921-74-8
2-(2-(2-methoxyethoxy)ethoxy)ethyl p-toluenesulfonate

: 6048-68-6
2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol

Conditions

Conditions	Yield
With potassium hydroxide In tetrahydrofuran for 18h; Inert atmosphere; Reflux;	65%

: 2615-15-8
pentaethylene glycol

: 72593-77-2
3,6,9-trioxadecyl bromide

: 6048-68-6
2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol

Conditions

Conditions	Yield
Stage #1: pentaethylene glycol With sodium hydride In toluene at 20℃; for 2h; Stage #2: 3,6,9-trioxadecyl bromide In toluene at 20℃; for 1h;	51%

: 4437-01-8
3,6,9,12,15,18,21-heptaoxadocosan-1-ol

: 6048-68-6
2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol

Conditions

Conditions	Yield
With benzenesulfonyl chloride; benzene Erwaermen des Reaktionsprodukts mit Natrium-diaethylenglykolat in Diaethylenglykol;

: 23601-40-3
hexaethylene glycol monomethyl ether

: 6048-68-6
2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol

Conditions

Conditions	Yield
With sodium hydroxide; benzenesulfonyl chloride; benzene Erwaermen des Reaktionsprodukts mit Natrium-triaethylenglykolat in Triaethylenglykol;

: 23778-52-1
3,6,9,12,15-pentaoxahexadecanol

: 6048-68-6
2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: benzene; benzenesulfonyl chloride; sodium hydroxide / Erwaermen des Reaktionsprodukts mit Natrium-diaethylenglykolat in Diaethylenglykol 2: benzene; benzenesulfonyl chloride / Erwaermen des Reaktionsprodukts mit Natrium-diaethylenglykolat in Diaethylenglykol View Scheme

: 112-35-6
triethylene glucol monomethyl ether

: 6048-68-6
2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium hydroxide; benzenesulfonyl chloride; benzene / Erwaermen des Reaktionsprodukts mit Natrium-triaethylenglykolat in Triaethylenglykol 2: sodium hydroxide; benzenesulfonyl chloride; benzene / Erwaermen des Reaktionsprodukts mit Natrium-triaethylenglykolat in Triaethylenglykol View Scheme

: 6048-68-6
2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol

: 106-96-7
propargyl bromide

: 1233324-30-5
2,5,8,11,14,17,20,23,26,29-decaoxadotriacont-31-yne

Conditions

Conditions	Yield
Stage #1: 2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol With sodium hydride In tetrahydrofuran; mineral oil Stage #2: propargyl bromide In tetrahydrofuran; mineral oil at 0 - 20℃; for 4h;	99%
With potassium tert-butylate In tetrahydrofuran at 0 - 20℃; for 168h; Inert atmosphere;	34%

: 6048-68-6
2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol

: 66885-68-5
(E)-p-formylcinnamic acid

: 4-Formylcinnamic acid nonaethylene glycol methyl ether ester

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In xylene for 4h; Heating / reflux;	97%

: 6048-68-6
2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol

: 102013-72-9
2,5,8,11,14,17,20,23,26-nonaoxaoctacosan-28-oic acid

Conditions

Conditions	Yield
With Jones reagent In acetone at 20℃; for 2h;	90%

: 6048-68-6
2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol

: 471-53-4
enoxolone

: C49H84O13

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 14h; Reagent/catalyst; Solvent; Temperature;	80%

: 6048-68-6
2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol

: 98-59-9
p-toluenesulfonyl chloride

: 211859-75-5
nonaethylene glycol methyl tosyl ether

Conditions

Conditions	Yield
With sodium hydroxide; PEG 550 In tetrahydrofuran; water	78%

: (14)CC30H36N6O3

: 6048-68-6
2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol

: (14)CC46H72N4O13

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile Heating;	71%

: 696661-26-4
C17H12O3

: 6048-68-6
2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol

: 1016567-41-1
2,5,8,11,14,17,20,23,26-nonaoxaoctacosan-28-yl 3-(4-methylphenyl)-1-oxo-1H-indene-2-carboxylate

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap In dichloromethane at 20℃;	68%

: 211859-64-2
(E)-1,3-Bis(cyclohexylmethyl)-8-(4-(2-(1H-imidazol-1-ylcarbonyl)vinyl)phenyl)-9H-purin-2,6(1H,3H)-dione

: 6048-68-6
2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol

: 211859-42-6
(E)-4-(1,3-Bis(cyclohexylmethyl)-1,2,3,6-tetrahydro-2.6-dioxo-9H-purin-8-yl)cinnamic Acid Nonaethylene Glycol Monomethyl Ether Ester

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile for 18h; Heating / reflux;	65%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 6048-68-6
2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol

: tert-butyl 2,5,8,11,14,17,20,23,26,29-decaoxahentriacontan-31-oate

Conditions

Conditions	Yield
Stage #1: 2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 0.5h; Stage #2: bromoacetic acid tert-butyl ester In tetrahydrofuran; mineral oil at 20℃; for 1h;	59%
Stage #1: 2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol With sodium hydride In tetrahydrofuran at 20℃; for 0.5h; Stage #2: bromoacetic acid tert-butyl ester In tetrahydrofuran at 20℃; for 1h;	59%
Stage #1: 2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol With sodium hydride In tetrahydrofuran at 20℃; for 0.5h; Stage #2: bromoacetic acid tert-butyl ester In tetrahydrofuran at 20℃; for 1h;	59%
Stage #1: 2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol With sodium hydride In tetrahydrofuran at 20℃; for 0.5h; Stage #2: bromoacetic acid tert-butyl ester In tetrahydrofuran at 20℃; for 1h;	59%

: 6048-68-6
2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol

: 73870-24-3
4-bromomethyl pyridine hydrobromide

: C25H45NO10

Conditions

Conditions	Yield
Stage #1: 2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol With sodium hydride In tetrahydrofuran; mineral oil at 25℃; for 0.5h; Inert atmosphere; Stage #2: 4-bromomethyl pyridine hydrobromide With sodium hydride In tetrahydrofuran; mineral oil at 25℃; for 14.5h; Inert atmosphere;	53%

: 211859-79-9
2-(1,3-Bis(cyclohexylmethyl)-1,2,3,6-tetrahydro-2,6-dioxo-9H-purin-8-yl)benzoic acid

: 6048-68-6
2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol

: 2-[1,3-Bis(cyclohexylmethyl)-1,2,3,6-tetrahydro-2,6-dioxo-9H-purin-8-yl]benzoic acid Nonaethylene Glycol Methyl Ether Ester

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile Heating / reflux;	43%

: 6048-68-6
2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol

: 125562-30-3
28-bromo-2,5,8,11,14,17,20,23,26-nonaoxaoctacosane

Conditions

Conditions	Yield
With phosphorus tribromide In diethyl ether at 0℃;	22%
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 16 h / 20 °C / Inert atmosphere 2: tetrabutylammomium bromide / acetonitrile / 16 h / 50 °C / Inert atmosphere View Scheme

: 177352-23-7
(E)-4-(1,3-Bis(cyclohexylmethyl)-1,2,3,6-tetrahydro-6-oxo-2-thioxo-9H-purin-8-yl)cinnamic Acid

: 6048-68-6
2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol

: (E)-4-(1,3-Bis(cyclohexylmethyl)-1,2,3,6-tetrahydro-6-oxo-2-thioxo-9H-purin-8-yl)cinnamic Acid Nonaethylene Glycol Methyl Ether Ester

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile Heating / reflux;	20%

: 87-06-9
3-butyl-1-chloro-isoquinoline

: 6048-68-6
2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol

: 104509-87-7
3-butyl-1-(26-methoxy-3,6,9,12,15,18,21,24-octaoxa-hexacosyloxy)-isoquinoline

Conditions

Conditions	Yield
With sodium at 100 - 110℃;

: 55150-50-0
4-butyl-1-chloro-isoquinoline

: 6048-68-6
2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol

: 104508-91-0
4-butyl-1-(26-methoxy-3,6,9,12,15,18,21,24-octaoxa-hexacosyloxy)-isoquinoline

Conditions

Conditions	Yield
With sodium at 100 - 110℃;

: 858194-04-4
1-chloro-3-hexylisoquinoline

: 6048-68-6
2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol

: 104399-40-8
3-hexyl-1-(26-methoxy-3,6,9,12,15,18,21,24-octaoxa-hexacosyloxy)-isoquinoline

Conditions

Conditions	Yield
With sodium at 110℃;

: 6048-68-6
2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol

: 1-methoxy-26-methylamino-3,6,9,12,15,18,21,24-octaoxa-hexacosane

Conditions

Conditions	Yield
With sodium hydroxide; benzenesulfonyl chloride; benzene Beim Erwaermen des Reaktionsprodukts mit Methylamin in Aethanol;
Multi-step reaction with 2 steps 1: 78 percent / NaOH; PEG 550 / H2O; tetrahydrofuran 2: 96 percent / ethanol View Scheme

: 1037620-58-8
(13)C6C22H34N4O4

: 6048-68-6
2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol

: (13)C6C41H72N4O13

: 6048-68-6
2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol

: 104-15-4
toluene-4-sulfonic acid

: 211859-75-5
nonaethylene glycol methyl tosyl ether

Conditions

Conditions	Yield
In pyridine at 20℃;

: (E)-1,3-bis(cyclohexylmethyl)-8-(3-(2-(1H-imidazol-1-ylcarbonyl)vinyl)phenyl)-9H-purin-2,6(1H,3H)-dione

: 6048-68-6
2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol

: (E)-3-[1,3-Bis(cyclohexylmethyl)-1,2,3,6-tetrahydro-2,6-dioxo-9H-purin-8-yl]cinnamic Acid Nonaethylene Glycol Methyl Ether Ester

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In DMF (N,N-dimethyl-formamide) at 55℃; for 20h;

: C31H34N6O3

: 6048-68-6
2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol

: 3-{4-[1,3-Bis(cyclohexylmethyl)-1,2,3,6-tetrahydro-2,6-dioxo-9H-purin-8-yl]phenyl}propiolic Acid Nonaethylene Glycol Methyl Ether Ester

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In DMF (N,N-dimethyl-formamide) at 20 - 40℃; for 2h;

Nonaethylene glycol monomethyl ether Specification

The Nonaethylene glycol monomethyl ether with cas registry number of 6048-68-6, belongs to the following product categories: Ethylene Glycols & Monofunctional Ethylene Glycols; Monofunctional Ethylene Glycols. This chemical's molecular formula is C19H40O10 and molecular weight is 428.51.Its systematic name is 2,5,8,11,14,17,20,23,26-nonaoxaoctacosan-28-ol.

Physical properties about Nonaethylene glycol monomethyl ether are: (1)ACD/BCF (pH 5.5): 1; (2)ACD/BCF (pH 7.4): 1; (3)ACD/KOC (pH 5.5): 1; (4)ACD/KOC (pH 7.4): 1; (5)#H bond acceptors: 10; (6)#H bond donors: 1; (7)#Freely Rotating Bonds: 27; (8)Polar Surface Area: 92.3 Å²; (9)Index of Refraction: 1.453; (10)Molar Refractivity: 107.31 cm³; (11)Molar Volume: 396.9 cm³; (12)Polarizability: 42.54×10^-24cm³; (13)Surface Tension: 37.4 dyne/cm; (14)Enthalpy of Vaporization: 87.15 kJ/mol; (15)Vapour Pressure: 1.17E-11 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES:O(CCOCCOCCO)CCOCCOCCOCCOCCOCCOC;
(2)InChI:InChI=1/C19H40O10/c1-21-4-5-23-8-9-25-12-13-27-16-17-29-19-18-28-15-14-26-11-10-24-7-6-22-3-2-20/h20H,2-19H2,1H3;
(3)InChIKey:VVHAVLIDQNWEKF-UHFFFAOYAD;

Product Name

NONAETHYLENE GLYCOL MONOMETHYL ETHER

Synthetic route

Nonaethylene glycol monomethyl ether Specification

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