Product Name

  • Name

    Salicylhydrazide

  • EINECS 213-311-3
  • CAS No. 936-02-7
  • Article Data176
  • CAS DataBase
  • Density 1.318 g/cm3
  • Solubility
  • Melting Point 147-150 °C(lit.)
  • Formula C7H8N2O2
  • Boiling Point 274.61°C (rough estimate)
  • Molecular Weight 152.153
  • Flash Point
  • Transport Information
  • Appearance white to off-white crystalline powder
  • Safety 26-36
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 936-02-7 (Salicylhydrazide)
  • Hazard Symbols IrritantXi
  • Synonyms o-Hydroxybenzhydrazide;o-Hydroxybenzoic acid hydrazide;o-Hydroxybenzoylhydrazide;Salicylicacid, hydrazide (6CI,7CI,8CI);2-Hydroxybenzenecarboxylic acid hydrazide;2-Hydroxybenzoic acid hydrazide;2-Hydroxybenzoichydrazide;NSC 652;Salicyl hydrazide;Salicyloyl hydrazide;
  • PSA 75.35000
  • LogP 1.08690

Synthetic route

2-hydroxy-benzoic acid ethyl ester
118-61-6

2-hydroxy-benzoic acid ethyl ester

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

Conditions
ConditionsYield
With hydrazine hydrate In ethanol at 70℃; for 0.00111111h;99.1%
With hydrazine hydrate In ethanol; water Reflux;85%
With hydrazine hydrate In ethanol at 80℃; for 12h;82%
methyl salicylate
119-36-8

methyl salicylate

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

Conditions
ConditionsYield
With hydrazine hydrate In ethanol for 0.0166667h; microwave irradiation;98%
With hydrazine hydrate In methanol for 6h; Reflux;94.9%
With hydrazine hydrate In methanol for 12h; Reflux;92%
salicylic acid
69-72-7

salicylic acid

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

Conditions
ConditionsYield
With hydrazine hydrate for 0.0388889h; Microwave irradiation;89%
Stage #1: salicylic acid With sulfuric acid In ethanol for 6h; Reflux;
Stage #2: With hydrazine hydrate; sodium hydrogencarbonate; acetic acid Reflux;		85%
Stage #1: salicylic acid With potassium carbonate; dimethyl sulfate In acetone at 55℃; for 24h;
Stage #2: With hydrazine hydrate In methanol for 2h; Reflux;		80%
n-butyl salicylate
2052-14-4

n-butyl salicylate

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

Conditions
ConditionsYield
With hydrazine hydrate In ethanol for 6h; Reflux;74.4%
phenyl Salicylate
118-55-8

phenyl Salicylate

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

Conditions
ConditionsYield
With hydrazine In isopropyl alcohol for 0.333333h; Heating;66%
With sodium hydroxide; hydrazine In water; acetonitrile at 30℃; Rate constant; pH=11.68-12.46, variation of pH;
methyl 2-amino-4-(4-methoxyphenyl)-5-oxo-4,5-dihydropyrano[3,2-c]chromene-3-carboxylate
607697-15-4

methyl 2-amino-4-(4-methoxyphenyl)-5-oxo-4,5-dihydropyrano[3,2-c]chromene-3-carboxylate

A

3-(5-amino-3-oxopyrazolin-4-yl)-3-(4-methoxyphenyl)propanoylhydrazide
1184912-51-3

3-(5-amino-3-oxopyrazolin-4-yl)-3-(4-methoxyphenyl)propanoylhydrazide

B

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

Conditions
ConditionsYield
With hydrazine hydrate In ethanol for 8h; Reflux;A 41%
B n/a
N'-benzylidene-2-hydroxybenzohydrazide
59395-02-7, 18269-02-8

N'-benzylidene-2-hydroxybenzohydrazide

A

benzaldehyde
100-52-7

benzaldehyde

B

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

Conditions
ConditionsYield
With ethanol-acidic buffer Rate constant; Thermodynamic data; the effects of pH, and temperature on the reaction rate and the activation energy and thermodynamic parameters;
With ethanol-acidic buffer Rate constant; Thermodynamic data; -ΔG(excit.), ΔH(excit.), -ΔS(excit), Ea(excit.);
2'-(4-dimethylaminobenzylidene)-2-hydroxybenzoylhydrazide
87444-18-6

2'-(4-dimethylaminobenzylidene)-2-hydroxybenzoylhydrazide

A

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

B

4-dimethylamino-benzaldehyde
100-10-7

4-dimethylamino-benzaldehyde

Conditions
ConditionsYield
With ethanol-acidic buffer Rate constant; Thermodynamic data; -ΔG(excit.), ΔH(excit.),-ΔS(excit), Ea(excit.);
N'-[(4-nitrophenyl)methylidene]-2-hydroxybenzohydrazide
72323-41-2

N'-[(4-nitrophenyl)methylidene]-2-hydroxybenzohydrazide

A

4-nitrobenzaldehdye
555-16-8

4-nitrobenzaldehdye

B

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

Conditions
ConditionsYield
With ethanol-acidic buffer Rate constant; Thermodynamic data; -ΔG(excit.), ΔH(excit.),-ΔS(excit), Ea(excit.);
N'-[(4-methoxyphenyl)methylidene]-2-hydroxybenzohydrazide
3291-01-8

N'-[(4-methoxyphenyl)methylidene]-2-hydroxybenzohydrazide

A

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

B

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

Conditions
ConditionsYield
With ethanol-acidic buffer Rate constant; Thermodynamic data; -ΔG(excit.), ΔH(excit.),-ΔS(excit), Ea(excit.);
2-nitro-benzylidene salicylichydrazide
70203-00-8

2-nitro-benzylidene salicylichydrazide

A

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

B

2-nitro-benzaldehyde
552-89-6

2-nitro-benzaldehyde

Conditions
ConditionsYield
With ethanol-acidic buffer Rate constant; Thermodynamic data; -ΔG(excit.), ΔH(excit.),-ΔS(excit), Ea(excit.);
(E)-N'-(4-hydroxybenzylidene)-2-hydroxybenzohydrazide
87444-15-3

(E)-N'-(4-hydroxybenzylidene)-2-hydroxybenzohydrazide

A

4-hydroxy-benzaldehyde
123-08-0

4-hydroxy-benzaldehyde

B

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

Conditions
ConditionsYield
With ethanol-acidic buffer Rate constant; Thermodynamic data; -ΔG(excit.), ΔH(excit.),-ΔS(excit), Ea(excit.);
salicylic acid-(3-nitro-benzylidenehydrazide)
72323-40-1

salicylic acid-(3-nitro-benzylidenehydrazide)

A

3-nitro-benzaldehyde
99-61-6

3-nitro-benzaldehyde

B

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

Conditions
ConditionsYield
With ethanol-acidic buffer Rate constant; Thermodynamic data; -ΔG(excit.), ΔH(excit.),-ΔS(excit), Ea(excit.);
phenyl Salicylate
118-55-8

phenyl Salicylate

A

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

B

phenol
108-95-2

phenol

Conditions
ConditionsYield
With sodium hydroxide; hydrazine hydrate In acetonitrile at 30℃; Rate constant; var. conc. of sodium dodecyl sulphate, DABCO, NaOH; other temperature: 37 deg C;
anionic phenyl salicylate
61141-14-8

anionic phenyl salicylate

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

Conditions
ConditionsYield
With sodium hydroxide; hydrazine In water; acetonitrile at 35℃; Kinetics; aminolysis;
Mn(2+)*C7H8N2O2*C7H8N2O*2Cl(1-)*NH3*H2O=Mn(C7H8N2O2)(C7H8N2O)Cl2*NH3*H2O

Mn(2+)*C7H8N2O2*C7H8N2O*2Cl(1-)*NH3*H2O=Mn(C7H8N2O2)(C7H8N2O)Cl2*NH3*H2O

A

manganese oxide

manganese oxide

B

benzoic acid hydrazide
613-94-5

benzoic acid hydrazide

C

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

Conditions
ConditionsYield
byproducts: H2O, Cl2, NH3; at 140°C loses water; at 340°C loses NH3 and benzohydrazide; at 510°C loses 2-hydroxybenzohydrazide and Cl2;
...Expand
Mn(2+)*2C7H8N2O2*C6H9N3O2*2Cl(1-)=Mn(C7H8N2O2)2(C6H9N3O2)Cl2

Mn(2+)*2C7H8N2O2*C6H9N3O2*2Cl(1-)=Mn(C7H8N2O2)2(C6H9N3O2)Cl2

A

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

B

manganese(ll) chloride

manganese(ll) chloride

C

D,L-histidine
71-00-1

D,L-histidine

Conditions
ConditionsYield
thermal decompn. with releasing 2-hydroxybenzohydrazide at 300 and 520°C, histidine at 580°C; MnCl2 converts into manganese oxide at 600°C;
...Expand
2-hydroxybenzoic acid ester

2-hydroxybenzoic acid ester

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

Conditions
ConditionsYield
With hydrazine hydrate In ethanol Reflux;
tert-butyl 2-(2-hydroxybenzoyl)hydrazinecarboxylate
1354716-45-2

tert-butyl 2-(2-hydroxybenzoyl)hydrazinecarboxylate

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane
N'-(2-phenyl-2-ethylidene)-2-hydroxybenzohydrazide
70203-02-0

N'-(2-phenyl-2-ethylidene)-2-hydroxybenzohydrazide

A

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

B

acetophenone
98-86-2

acetophenone

Conditions
ConditionsYield
With sulfuric acid In water
N'-[2-(4-chlorophenyl)-2-ethylidene]-2-hydroxybenzohydrazide

N'-[2-(4-chlorophenyl)-2-ethylidene]-2-hydroxybenzohydrazide

A

para-chloroacetophenone
99-91-2

para-chloroacetophenone

B

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

Conditions
ConditionsYield
With sulfuric acid In water
N'-[2-(4-bromophenyl)-2-ethylidene]-2-hydroxybenzohydrazide

N'-[2-(4-bromophenyl)-2-ethylidene]-2-hydroxybenzohydrazide

A

para-bromoacetophenone
99-90-1

para-bromoacetophenone

B

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

Conditions
ConditionsYield
With sulfuric acid In water
N'-[2-(4-nitrophenyl)-2-ethylidene]-2-hydroxybenzohydrazide

N'-[2-(4-nitrophenyl)-2-ethylidene]-2-hydroxybenzohydrazide

A

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

B

(4-nitrophenyl)ethanone
100-19-6

(4-nitrophenyl)ethanone

Conditions
ConditionsYield
With sulfuric acid In water
N'-[2-(4-methylphenyl)-2-ethylidene]-2-hydroxybenzohydrazide

N'-[2-(4-methylphenyl)-2-ethylidene]-2-hydroxybenzohydrazide

A

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

B

para-methylacetophenone
122-00-9

para-methylacetophenone

Conditions
ConditionsYield
With sulfuric acid In water
salicylamide
65-45-2

salicylamide

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

Conditions
ConditionsYield
With methylethyl ketazine; water at 100 - 120℃;145.2 g
potassium thioacyanate
333-20-0

potassium thioacyanate

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

1-(2-hydroxybenzoyl)-3-thiosemicarbazide
58975-69-2

1-(2-hydroxybenzoyl)-3-thiosemicarbazide

Conditions
ConditionsYield
With hydrogenchloride In water100%
With hydrogenchloride In water at 95℃; for 4h;84%
With hydrogenchloride for 3h; Heating;
With hydrogenchloride In water
1-(2-furyl)-1-ethanone
1192-62-7

1-(2-furyl)-1-ethanone

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

(E)-N'-(1-(furan-2-yl)ethylidene)-2-hydroxybenzohydrazide
1206732-62-8

(E)-N'-(1-(furan-2-yl)ethylidene)-2-hydroxybenzohydrazide

Conditions
ConditionsYield
at 194℃; under 4650.47 Torr; for 0.0416667h; Microwave irradiation; neat (no solvent);100%
cyclohexanone
108-94-1

cyclohexanone

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

N'-cyclohexylidene-2-hydroxybenzohydrazide
100615-79-0

N'-cyclohexylidene-2-hydroxybenzohydrazide

Conditions
ConditionsYield
at 137℃; under 1875.19 Torr; for 0.0666667h; Microwave irradiation; neat (no solvent);100%
2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

cyclopentanone
120-92-3

cyclopentanone

N'-cyclopentylidene-2-hydroxybenzohydrazide
100135-10-2

N'-cyclopentylidene-2-hydroxybenzohydrazide

Conditions
ConditionsYield
at 114℃; under 1425.14 Torr; for 0.0833333h; Microwave irradiation; neat (no solvent);100%
4-(Diethylamino)salicylaldehyde
17754-90-4

4-(Diethylamino)salicylaldehyde

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

N’-[4-(diethylamino)-2-hydroxybenzylidene]-2-hydroxybenzohydrazide
316130-82-2

N’-[4-(diethylamino)-2-hydroxybenzylidene]-2-hydroxybenzohydrazide

Conditions
ConditionsYield
With acetic acid at 20℃;100%
In methanol for 1h; Reflux;89%
With piperidine In ethanol for 4h; Reflux;81%
In ethanol at 78℃; for 0.6h;80%
5-(2',4'-difluorophenyl)furan-2-carbaldehyde

5-(2',4'-difluorophenyl)furan-2-carbaldehyde

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

(E)-5-(2',4-difluorophenyl)furan-2-carbaldehyde 2-hydroxybenzoylhydrazone
1259371-00-0

(E)-5-(2',4-difluorophenyl)furan-2-carbaldehyde 2-hydroxybenzoylhydrazone

Conditions
ConditionsYield
With acetic acid In ethanol for 5h; Reflux; diastereoselective reaction;99.68%
4-((methylthio)(phenyl)methylene) morpholinium iodide
31646-28-3

4-((methylthio)(phenyl)methylene) morpholinium iodide

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

2-(5-phenyl-1,3,4-oxadiazol-2-yl)phenol
18233-24-4

2-(5-phenyl-1,3,4-oxadiazol-2-yl)phenol

Conditions
ConditionsYield
In pyridine for 16h; Ambient temperature;99%
1-(α-methylsulfanyl-benzylidene)-piperidinium; iodide
61135-82-8

1-(α-methylsulfanyl-benzylidene)-piperidinium; iodide

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

2-(5-phenyl-1,3,4-oxadiazol-2-yl)phenol
18233-24-4

2-(5-phenyl-1,3,4-oxadiazol-2-yl)phenol

Conditions
ConditionsYield
In pyridine for 16h; Ambient temperature;99%
2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

4-(m-chloro-α-methylthiobenzylidene)morpholinium iodide
76591-84-9

4-(m-chloro-α-methylthiobenzylidene)morpholinium iodide

2-[5-(3-Chloro-phenyl)-[1,3,4]oxadiazol-2-yl]-phenol
111997-56-9

2-[5-(3-Chloro-phenyl)-[1,3,4]oxadiazol-2-yl]-phenol

Conditions
ConditionsYield
In pyridine for 16h; Ambient temperature;99%
3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one
771-03-9

3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

3-[1-(2'-hydroxybenzoyl)-hydrazono-ethyl]-4-hydroxy-6-methyl-2H-pyran-2-one

3-[1-(2'-hydroxybenzoyl)-hydrazono-ethyl]-4-hydroxy-6-methyl-2H-pyran-2-one

Conditions
ConditionsYield
In methanol for 2h; Reflux;99%
2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

phenylacetylene
536-74-3

phenylacetylene

(E)-2-hydroxy-N'-(1-phenylethylidene)benzohydrazide
1206732-60-6

(E)-2-hydroxy-N'-(1-phenylethylidene)benzohydrazide

Conditions
ConditionsYield
With [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I) In chlorobenzene at 60℃; for 2h;99%
2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

1-isothiocyanato-4-methylbenzene
622-59-3

1-isothiocyanato-4-methylbenzene

1-salicyloyl-4-p-tolyl thiosemicarbazide
94565-94-3

1-salicyloyl-4-p-tolyl thiosemicarbazide

Conditions
ConditionsYield
In ethanol for 1h; Heating;98%
ethyl 4-oxo-1,4-dihydro-2H-3,1-benzoxazine-2-carboxylate
31143-83-6

ethyl 4-oxo-1,4-dihydro-2H-3,1-benzoxazine-2-carboxylate

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

2-({Ethoxycarbonyl-[(2-hydroxy-benzoyl)-hydrazono]-methyl}-amino)-benzoic acid
82059-05-0

2-({Ethoxycarbonyl-[(2-hydroxy-benzoyl)-hydrazono]-methyl}-amino)-benzoic acid

Conditions
ConditionsYield
In 1,4-dioxane Heating;98%
phenyl isothiocyanate
103-72-0

phenyl isothiocyanate

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

2-(2-hydroxybenzoyl)-N-phenylhydrazincarbothioamide
37536-32-6

2-(2-hydroxybenzoyl)-N-phenylhydrazincarbothioamide

Conditions
ConditionsYield
In ethanol for 0.05h; microwave irradiation;98%
In ethanol at 50 - 60℃; for 10h;88.8%
In ethanol for 0.25h; Reflux;86%
4-Chlorophenyl isothiocyanate
2131-55-7

4-Chlorophenyl isothiocyanate

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

4-(4-chlorophenyl)-1-(2-hydroxybenzoyl)-3-thiosemicarbazide
26131-23-7

4-(4-chlorophenyl)-1-(2-hydroxybenzoyl)-3-thiosemicarbazide

Conditions
ConditionsYield
In ethanol for 1h; Heating;98%
In ethanol for 0.25h; Reflux;85%
In methanol at 20℃; under 760.051 Torr; for 24h;20%
2,5-dimethylphenyl isothiocyanate
19241-15-7

2,5-dimethylphenyl isothiocyanate

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

C16H17N3O2S
94565-95-4

C16H17N3O2S

Conditions
ConditionsYield
In ethanol for 1h; Heating;98%
2-thioxo-5H-1,3-dithiolo[4,5-b][1,4]dithiepin-6(7H)-one
129993-53-9

2-thioxo-5H-1,3-dithiolo[4,5-b][1,4]dithiepin-6(7H)-one

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

2-Hydroxy-benzoic acid (2-thioxo-[1,3]dithiolo[4,5-b][1,4]dithiepin-6-ylidene)-hydrazide

2-Hydroxy-benzoic acid (2-thioxo-[1,3]dithiolo[4,5-b][1,4]dithiepin-6-ylidene)-hydrazide

Conditions
ConditionsYield
In diethyl ether Ambient temperature;98%
succinic acid anhydride
108-30-5

succinic acid anhydride

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

4-[N'-(2-hydroxy-benzoyl)-hydrazino]-4-oxo-butyric acid

4-[N'-(2-hydroxy-benzoyl)-hydrazino]-4-oxo-butyric acid

Conditions
ConditionsYield
In ethyl acetate at 20℃;98%
2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

butanone
78-93-3

butanone

(E)-N'-(butan-2-ylidene)-2-hydroxybenzohydrazide
1206732-58-2

(E)-N'-(butan-2-ylidene)-2-hydroxybenzohydrazide

Conditions
ConditionsYield
at 95℃; under 1575.16 Torr; for 0.05h; Microwave irradiation; neat (no solvent);98%
2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

2-mercaptopropanoic acid
79-42-5

2-mercaptopropanoic acid

1-methylcyclohexan-4-one
589-92-4

1-methylcyclohexan-4-one

2-hydroxy-N-(2,8-dimethyl-3-oxo-1-thia-4-azaspiro[4.5]dec-4-yl)benzamide

2-hydroxy-N-(2,8-dimethyl-3-oxo-1-thia-4-azaspiro[4.5]dec-4-yl)benzamide

Conditions
ConditionsYield
In benzene for 6h; Reflux; Dean-Stark;98%
...Expand
2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carboxylic acid

1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carboxylic acid

N'-(2-hydroxybenzoyl)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbohydrazide

N'-(2-hydroxybenzoyl)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbohydrazide

Conditions
ConditionsYield
Stage #1: 2-Hydroxybenzoylhydrazine; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carboxylic acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate In N,N-dimethyl-formamide for 0.333333h;
Stage #2: With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 1h;		98%
2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

3-imino-2H-phenylchromene-2-carbonitrile
80860-05-5

3-imino-2H-phenylchromene-2-carbonitrile

C21H13N3O3

C21H13N3O3

Conditions
ConditionsYield
With acetic acid In chloroform at 20℃; for 144h;98%
4,5-Diazafluoren-9-one
50890-67-0

4,5-Diazafluoren-9-one

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

4,5-diazafluorene-9-one salicyloylhydrazone
301669-06-7

4,5-diazafluorene-9-one salicyloylhydrazone

Conditions
ConditionsYield
With toluene-4-sulfonic acid In ethanol for 6h; Reflux;97.4%
2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

2-tolyl isothiocyanate
614-69-7

2-tolyl isothiocyanate

1-(2-Hydroxy-benzoyl)-4-(2-methyl-phenyl)-thiosemicarbazid
81518-25-4

1-(2-Hydroxy-benzoyl)-4-(2-methyl-phenyl)-thiosemicarbazid

Conditions
ConditionsYield
In ethanol for 1h; Heating;97%
2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

7,7-dimethyl-2-(4-pyridyl)-5,6,7,8-tetrahydro-5-quinazolone
213271-09-1

7,7-dimethyl-2-(4-pyridyl)-5,6,7,8-tetrahydro-5-quinazolone

5-(2-hydroxybenzoylhydrazono)-2-(4-pyridyl)-7,7-dimethyl-5,6,7,8-tetrahydroquinazoline

5-(2-hydroxybenzoylhydrazono)-2-(4-pyridyl)-7,7-dimethyl-5,6,7,8-tetrahydroquinazoline

Conditions
ConditionsYield
In pyridine for 3.5h; Heating;97%
3-acetyl-4-hydroxychromen-2-one
2555-37-5

3-acetyl-4-hydroxychromen-2-one

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

3-{1-[(2-hydroxybenzoyl)hydrazono]ethyl}-4-hydroxy-2H-1-benzopyran-2-one
1352444-55-3

3-{1-[(2-hydroxybenzoyl)hydrazono]ethyl}-4-hydroxy-2H-1-benzopyran-2-one

Conditions
ConditionsYield
In propan-1-ol for 24h; Reflux;97%
In propan-1-ol for 24h; Reflux;97%
2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

mercaptoacetic acid
68-11-1

mercaptoacetic acid

4-tercbutyl-cyclohexanone
98-53-3

4-tercbutyl-cyclohexanone

2-hydroxy-N-(3-oxo-8-tert-butyl-1-thia-4-azaspiro[4.5]dec-4-yl)benzamide

2-hydroxy-N-(3-oxo-8-tert-butyl-1-thia-4-azaspiro[4.5]dec-4-yl)benzamide

Conditions
ConditionsYield
In benzene for 6h; Reflux; Dean-Stark;97%
...Expand
4-methyl-1,2,3-thiadiazole-5-carbaldehyde
127108-66-1

4-methyl-1,2,3-thiadiazole-5-carbaldehyde

2-Hydroxybenzoylhydrazine
936-02-7

2-Hydroxybenzoylhydrazine

C11H10N4O2S

C11H10N4O2S

Conditions
ConditionsYield
In ethanol Reflux;97%

Salicylhydrazide Chemical Properties

IUPAC Name: 2-Hydroxybenzohydrazide
The MF of 2-Hydroxybenzohydrazide (936-02-7) is C7H8N2O2.

                               
The MW of 2-Hydroxybenzohydrazide (936-02-7) is 152.15.
Synonyms of 2-Hydroxybenzohydrazide (936-02-7): 2-Hydroxybenzene-1-carbohydrazide ; 2-Hydroxybenzohydrazide ; Benzoic acid, 2-hydroxy-, hydrazide ; 2-Hydroxybenzoic acid hydrazide ; 2-Hydroxybenzoylhydrazine
Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes
Form: white to off-white crystalline powder
Index of Refraction: 1.622  
EINECS: 213-311-3
Density: 1.318 g/ml
Melting Point: 147-150 °C
Solubility in water: Soluble
BRN: 472355

Salicylhydrazide Toxicity Data With Reference

1.    

ipr-mus LD50:100 mg/kg

     JMPCAS    Journal of Medicinal and Pharmaceutical Chemistry. 4 (1961),259.

Salicylhydrazide Consensus Reports

Reported in EPA TSCA Inventory.

Salicylhydrazide Safety Profile

Poison by intraperitoneal route. When heated to decomposition it emits toxic vapors of NOx.
Safety information of 2-Hydroxybenzohydrazide (936-02-7):
Hazard Codes  Xi
Risk Statements 
36/37/38  Irritating to eyes, respiratory system and skin
Safety Statements 
26  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36  Wear suitable protective clothing
WGK Germany  3
RTECS  VO3700000

Salicylhydrazide Specification

Store in a cool, dry place. Keep container closed when not in use.Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.

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