Tetradecanedioic acid supplier

Name
Tetradecanedioic acid
EINECS 212-476-9
CAS No. 821-38-5
Article Data39
CAS DataBase
Density 1.038 g/cm³
Solubility slightly soluble in water
Melting Point 124-127 °C(lit.)
Formula C₁₄H₂₆O₄
Boiling Point 434.1 °C at 760 mmHg
Molecular Weight 258.358
Flash Point 230.5 °C
Transport Information
Appearance white fine powder
Safety 26-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 1,12-Dicarboxydodecane;1,12-Dodecanedicarboxylic acid;1,14-Tetradecanedioic acid;DCA 14;NSC 9504;Tetradecane-1,14-dioic acid;
PSA 74.60000
LogP 3.83680

Synthetic route

: 81393-28-4
C22H34O8

: 821-38-5
1,14-tetradecanedioic acid

Conditions

Conditions	Yield
With hydrogenchloride In water Heating;	96%

: 87145-86-6
2,2':5',2"-terthiophene-5,5"-dicarboxylic acid

: 821-38-5
1,14-tetradecanedioic acid

Conditions

Conditions	Yield
With nickel In water for 20h; Heating;	85%

: 201230-82-2
carbon monoxide

: 22104-81-0
dodec-2-en-1-ol

: 821-38-5
1,14-tetradecanedioic acid

Conditions

Conditions	Yield
With HeMaRaphos; water; toluene-4-sulfonic acid; palladium dichloride In tetrahydrofuran at 125℃; under 30003 Torr; for 24h; Autoclave; Green chemistry; regioselective reaction;	60%

: 1647-16-1
1,10-decadiene

: 108-24-7
acetic anhydride

A: 65423-25-8
11-dodecenoic acid

B: 821-38-5
1,14-tetradecanedioic acid

Conditions

Conditions	Yield
With oxygen; cobalt(II) acetate; manganese(II) acetate In acetic acid at 130℃; for 5h;	A 18% B 8%

...Expand

: 110-52-1
1,4-dibromo-butane

: 821-38-5
1,14-tetradecanedioic acid

Conditions

Conditions	Yield
With diethyl ether; magnesium Behandeln des Reaktionprodukts mit CO2;

: 24772-65-4
1,12-diiodododecane

: 151-50-8
potassium cyanide

: 821-38-5
1,14-tetradecanedioic acid

Conditions

Conditions	Yield
With ethanol Erwaermen des Reaktionsgemisches mit aethanol.Kalilauge;

: 17351-34-7
pentadec-14-enoic acid

: 821-38-5
1,14-tetradecanedioic acid

Conditions

Conditions	Yield
With ozone

: 17278-74-9
14-hydroxymyristic acid

: 821-38-5
1,14-tetradecanedioic acid

Conditions

Conditions	Yield
With chromic acid; acetic acid

: 45281-27-4
docos-14-enoic acid

A: 124-07-2
Octanoic acid

B: 821-38-5
1,14-tetradecanedioic acid

Conditions

Conditions	Yield
Ozonspaltung;

: 3860-19-3
4,11-dioxo-tetradecanedioic acid

: 821-38-5
1,14-tetradecanedioic acid

Conditions

Conditions	Yield
With potassium hydroxide; hydrazine hydrate; diethylene glycol
With sodium hydroxide; hydrazine hydrate In diethylene glycol at 200 - 220℃;

: 101108-19-4
7-semicarbazono-tetradecanedioic acid

: 821-38-5
1,14-tetradecanedioic acid

Conditions

Conditions	Yield
With potassium hydroxide; hydrazine hydrate; diethylene glycol

: 502-30-7
13-cyclopent-2-enyl-tridecanoic acid

: 821-38-5
1,14-tetradecanedioic acid

Conditions

Conditions	Yield
With permanganate(VII) ion

: 3603-99-4
cyclotetradecanone

: 821-38-5
1,14-tetradecanedioic acid

Conditions

Conditions	Yield
With chromium(VI) oxide; acetic acid

: 855359-65-8
2,2'-ethanediyl-bis-cyclohexane-1,3-dione

: 821-38-5
1,14-tetradecanedioic acid

Conditions

Conditions	Yield
With sodium hydroxide; hydrazine hydrate; diethylene glycol at 125℃; Reagens 4: Methanol; anschliessend auf 195grad;

: 540-88-5
acetic acid tert-butyl ester

: 4101-68-2
1,10-dibromodecane

: 821-38-5
1,14-tetradecanedioic acid

Conditions

Conditions	Yield
With lithium amide; ammonia at -40℃; Erhitzen des Reaktionsprodukts mit Dioxan und konz. wss. Salzsaeure;

: 1007476-32-5
sodium ethyl acetylacetate enolate

: 4101-68-2
1,10-dibromodecane

: 821-38-5
1,14-tetradecanedioic acid

Conditions

Conditions	Yield
With ethanol Erwaermen des Reaktionsprodukts mit konz.wss.Kalilauge;

: 7735-44-6
Tetradecandisaeuredinitril

: 821-38-5
1,14-tetradecanedioic acid

Conditions

Conditions	Yield
With sulfuric acid; acetic anhydride In water Heating;

: 5024-21-5
dimethyl tetradecanedioate

: 821-38-5
1,14-tetradecanedioic acid

Conditions

Conditions	Yield
With sodium hydroxide In methanol
saponification;
With potassium hydroxide In methanol for 24h; Heating;

: 14108-92-0
cyclopentadeca-1,2-diene

: 821-38-5
1,14-tetradecanedioic acid

Conditions

Conditions	Yield
(i) O3, (ii) AcOOH; Multistep reaction;

: carboxy-methyl sodium ; sodium-salt

: 4101-68-2
1,10-dibromodecane

: 821-38-5
1,14-tetradecanedioic acid

Conditions

Conditions	Yield
With sodium isopropylate

: 32400-35-4
2-(3-Methylbut-2-enyliden)-cyclododecanon

: 821-38-5
1,14-tetradecanedioic acid

Conditions

Conditions	Yield
With ozone

: 57-57-8
β-Propiolactone

: 45037-87-4
1,8-octanediyldimagnesium dibromide

: 821-38-5
1,14-tetradecanedioic acid

Conditions

Conditions	Yield
With dilithium tetrachlorocuprate In tetrahydrofuran at 0℃; for 3h;

: 88739-43-9
1-(tert-Butyl-dimethyl-silanyloxy)-cycloheptyl-hydroperoxide

: 821-38-5
1,14-tetradecanedioic acid

Conditions

Conditions	Yield
With sulfuric acid; water; iron(II) sulfate 1.) 0 deg C, methanol 2.) RT; Yield given. Multistep reaction;

: 502-42-1
cycloheptanone

A: 111-16-0
heptanedioic acid

B: 111-14-8
oenanthic acid

C: 821-38-5
1,14-tetradecanedioic acid

D: 55311-03-0
(1,1'-bicycloheptyl)-2,2'-dione

E: 55311-13-2
7-(2-Oxo-cycloheptyl)-heptanoic acid

Conditions

Conditions	Yield
With dihydrogen peroxide at 120 - 140℃; Product distribution; oxidative cleavage of cycloalkanones by hydrogen peroxide;

...Expand

: 502-42-1
cycloheptanone

A: 111-16-0
heptanedioic acid

B: 111-14-8
oenanthic acid

C: 821-38-5
1,14-tetradecanedioic acid

D: 55311-13-2
7-(2-Oxo-cycloheptyl)-heptanoic acid

Conditions

Conditions	Yield
With dihydrogen peroxide at 120 - 140℃; Yield given. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;

...Expand

: 502-42-1
cycloheptanone

A: 111-14-8
oenanthic acid

B: 821-38-5
1,14-tetradecanedioic acid

C: 55311-03-0
(1,1'-bicycloheptyl)-2,2'-dione

D: 55311-13-2
7-(2-Oxo-cycloheptyl)-heptanoic acid

Conditions

Conditions	Yield
With dihydrogen peroxide at 120 - 140℃; Yield given. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;

...Expand

: 2,3,17-Trioxabicyclo<12.2.1>heptadecane

A: 821-38-5
1,14-tetradecanedioic acid

B: 14-oxotetradecanoic acid

Conditions

Conditions	Yield
In benzene-d6 at 80℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

: 5675-51-4
1,12-dodecandiol

carbon monoxide: carbon monoxide

: 821-38-5
1,14-tetradecanedioic acid

Conditions

Conditions	Yield
With iodine; tetracarbonyl nickel at 260℃; under 147102 Torr;

dodecane-tetracarboxylic acid-(1.1.12.12): dodecane-tetracarboxylic acid-(1.1.12.12)

: 821-38-5
1,14-tetradecanedioic acid

: 821-38-5
1,14-tetradecanedioic acid

: 19812-64-7
1,14-tetradecanediol

Conditions

Conditions	Yield
With borane In tetrahydrofuran Reflux;	100%
With dimethylsulfide borane complex In tetrahydrofuran at 50℃; for 4h; Reduction;	98%
With dimethylsulfide borane complex In tetrahydrofuran at 0 - 20℃; for 7h;	97%

: 67-56-1
methanol

: 821-38-5
1,14-tetradecanedioic acid

: 5024-21-5
dimethyl tetradecanedioate

Conditions

Conditions	Yield
With thionyl chloride for 24h; Inert atmosphere;	100%
With sulfuric acid Heating;
With thionyl chloride at 20℃; for 6h;
With thionyl chloride at 20℃;

: 821-38-5
1,14-tetradecanedioic acid

: 21646-49-1
tetradecanedioyl dichloride

Conditions

Conditions	Yield
With oxalyl dichloride In chloroform at 20℃; Heating / reflux;	99%
With oxalyl dichloride In chloroform at 20℃; Heating / reflux;	99%
With oxalyl dichloride In dichloromethane at 20℃; for 24h; Inert atmosphere;	91%

: 592-84-7
n-butyl formate

: 821-38-5
1,14-tetradecanedioic acid

A: 15805-82-0
Tetradecanedioic acid dibutyl ester

B: Tetradecanedioic acid monobutyl ester

Conditions

Conditions	Yield
With Dowex 50W-X2 (50-100 mesh) In octane at 100℃; for 12.5h;	A 6% B 89%
With Dowex 50Wx2 In octane at 100℃; for 12.5h; Esterification;	A 6% B 89%

...Expand

: 821-38-5
1,14-tetradecanedioic acid

: 57-88-5
cholesterol

: tetradecanedioic acid bis-[17-(1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] ester

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 12h;	87%

: 63987-96-2
thallium salt of Δ2-1,3-thiazoline-2-thiol

: 821-38-5
1,14-tetradecanedioic acid

: 74058-86-9
1,14-Bis-(2-thioxo-thiazolidin-3-yl)-tetradecane-1,14-dione

Conditions

Conditions	Yield
In tetrahydrofuran Ambient temperature;	85%

: 821-38-5
1,14-tetradecanedioic acid

: Tetradecanoic acid (R)-4-[(2-tert-butoxycarbonylamino-ethoxy)-methoxy-phosphoryloxy]-3-hydroxy-butyl ester

: Tetradecanedioic acid bis-{(R)-1-[(2-tert-butoxycarbonylamino-ethoxy)-methoxy-phosphoryloxymethyl]-3-tetradecanoyloxy-propyl} ester

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide; dmap In dichloromethane at 0 - 24℃; for 12h;	84%

: 821-38-5
1,14-tetradecanedioic acid

: 190579-30-7
3β-hydroxy-14β,16β-O-(4-methoxybenzylidene)card-20(22)-enolide

: 190579-40-9
hydrogen 14β,16β-O-(4-methoxybenzylidene)card-20(22)-enolide-3β-yl 1,12-dodecanedicarboxylate

Conditions

Conditions	Yield
With pyridine; p-toluenesulfonyl chloride for 4h; Ambient temperature;	81%

: 123-86-4
acetic acid butyl ester

: 821-38-5
1,14-tetradecanedioic acid

A: 15805-82-0
Tetradecanedioic acid dibutyl ester

B: Tetradecanedioic acid monobutyl ester

Conditions

Conditions	Yield
With Dowex 50Wx2 In octane at 110℃; for 25h; Esterification;	A 4% B 80%

...Expand

: 821-38-5
1,14-tetradecanedioic acid

: 101403-24-1
(S)-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-propylamine hydrochloride

: 1403823-09-5
N1,N14-bis((S)-5-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-N1,N14-dipropyltetradecanediamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 24h;	80%

: 821-38-5
1,14-tetradecanedioic acid

: 124-68-5
2-Amino-2-methyl-1-propanol

: 1194063-44-9
C22H40N2O2

Conditions

Conditions	Yield
at 170℃; for 0.416667h; Microwave irradiation; Neat (no solvent); open vessel;	78%

: 821-38-5
1,14-tetradecanedioic acid

: 95-54-5
1,2-diamino-benzene

: 158076-61-0
C26H34N4

Conditions

Conditions	Yield
With hydrogenchloride at 135℃; for 20h;	76%

: 821-38-5
1,14-tetradecanedioic acid

: 25526-93-6
alovudine

: 3'-fluoro-2′,3′-dideoxy-5'-O-(13-carboxyltridecanoate)thymidine

Conditions

Conditions	Yield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 4h;	75%

: 821-38-5
1,14-tetradecanedioic acid

: 82389-25-1
phorbol 13-acetate 20-tritylether

: 561063-36-3
Tetradecanedioic acid mono-((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-acetoxy-4a,7b-dihydroxy-1,1,6,8-tetramethyl-5-oxo-3-trityloxymethyl-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl) ester

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at -78 - 20℃;	73%

: 821-38-5
1,14-tetradecanedioic acid

: 92590-31-3
phorbol 12-acetate-20-trityl

: 561063-48-7
Tetradecanedioic acid mono-((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9-acetoxy-4a,7b-dihydroxy-1,1,6,8-tetramethyl-5-oxo-3-trityloxymethyl-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-cyclopropa[3,4]benzo[1,2-e]azulen-9a-yl) ester

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃;	73%

: 821-38-5
1,14-tetradecanedioic acid

: 36062-19-8
1,3-diaminoguanidine hydrochloride

: 1338484-49-3
1,12-bis(3,4-diamino-1,2,4-triazol-5-yl)dodecane

Conditions

Conditions	Yield
Stage #1: 1,14-tetradecanedioic acid; 1,3-diaminoguanidine hydrochloride at 50 - 120℃; for 4.5h; Stage #2: With sodium hydroxide In water pH=8;	72%

: 821-38-5
1,14-tetradecanedioic acid

: 24666-56-6
rac-α-aminoglutarimide hydrochloride

: N1,N14-bis(2,6-dioxopiperidin-3-yl)tetradecanediamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃;	72%

: 821-38-5
1,14-tetradecanedioic acid

: 1078691-95-8
(+)-D-glucosamine hydrochloride

: C20H37NO8

Conditions

Conditions	Yield
With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; sodium hydroxide In methanol; water at 20℃;	70%
Stage #1: 1,14-tetradecanedioic acid With sodium hydroxide In methanol at 20℃; Stage #2: (+)-D-glucosamine hydrochloride With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride at 20℃; for 30h;	64%

: 821-38-5
1,14-tetradecanedioic acid

: 1365246-86-1
(-)-N4-(4,4'-dimethoxytrityl)-5-fluoro-2',3'-dideoxy-3'-thiacytidine

: C43H52FN3O8S

Conditions

Conditions	Yield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;	68%

: 821-38-5
1,14-tetradecanedioic acid

: 85721-33-1
ciprofloxacin

: 1350462-69-9
C48H58F2N6O8

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 4h;	66%

: 821-38-5
1,14-tetradecanedioic acid

: 30516-87-1
3'-azido-2',3'-deoxythymidine

: 1396742-25-8
C34H48N10O10

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 20℃; for 12h;	61%
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;	30%

: 3590-93-0, 85440-15-9, 123287-54-7, 123287-57-0
4'-demethyl-4-deoxypodophyllotoxin

: 821-38-5
1,14-tetradecanedioic acid

: Tetradecanedioic acid mono-[2,6-dimethoxy-4-((5R,5aR,8aR)-6-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl)-phenyl] ester

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0℃; for 2h;	60%

: 821-38-5
1,14-tetradecanedioic acid

: 80379-10-8, 108530-03-6, 142631-59-2, 3205-25-2
1-(2-nitrophenyl)ethan-1-ol

: N-(2-{1-[(13-carboxytridecanoyl)oxy]ethyl}phenyl)-N-oxohydroxylammonium

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; N,N-dimethyl-formamide at 0 - 25℃; Inert atmosphere;	58%

: 821-38-5
1,14-tetradecanedioic acid

: 443-48-1
metronidazole

: C20H33N3O6

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dimethyl sulfoxide at 40℃; for 24h;	57.4%

: 821-38-5
1,14-tetradecanedioic acid

: tetradecanedioyl difluoride

Conditions

Conditions	Yield
With sodium fluoride; ethanaminium,N-(difluoro-λ4-sulfanylidene)-N-ethyl-,tetrafluoroborate at 20℃; for 24h; Inert atmosphere;	57%

: 7-[4-(2-chloroacetyl) piperazin-1-yl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

: 821-38-5
1,14-tetradecanedioic acid

: 1350462-75-7
C52H62F2N6O12

Conditions

Conditions	Yield
Stage #1: 1,14-tetradecanedioic acid With caesium carbonate In N,N-dimethyl-formamide at 50℃; for 1h; Stage #2: 7-[4-(2-chloroacetyl) piperazin-1-yl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid With tetra-(n-butyl)ammonium iodide In N,N-dimethyl-formamide at 50℃; for 72h;	56%

: 821-38-5
1,14-tetradecanedioic acid

: [1-deamino,8-lysine]vasotocin

: C100H154N24O26S4

Conditions

Conditions	Yield
With 1-hydroxy-pyrrolidine-2,5-dione; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide In N,N-dimethyl-formamide for 7h;	56%

Tetradecanedioic acid Chemical Properties

IUPAC Name: Tetradecanedioic acid
Systematic of Tetradecanedioic acid (CAS NO.821-38-5): 1,12-Dodecanedicarboxylic acid ; EINECS 212-476-9 ; NSC 9504 ; Tetradecane-1,14-dioic acid
CAS NO: 821-38-5
Molecular Formula of Tetradecanedioic acid (CAS NO.821-38-5): C₁₄H₂₆O₄
Molecular Weight: 258.3538
Molecular Structure:

Product Categories: alpha,omega-Alkanedicarboxylic Acids ; alpha,omega-Bifunctional Alkanes ; Monofunctional & alpha,omega-Bifunctional Alkanes
Melting Point: 124-127 °C
Polar Surface Area: 52.6 Å²
Index of Refraction: 1.474
Molar Refractivity: 70.03 cm³
Molar Volume: 248.8 cm³
Surface Tension: 41.7 dyne/cm
Density of Tetradecanedioic acid (CAS NO.821-38-5): 1.038 g/cm³
Flash Point: 230.5 °C
Enthalpy of Vaporization: 75.67 kJ/mol
Boiling Point: 434.1 °C at 760 mmHg
Vapour Pressure: 9.48E-09 mmHg at 25°C

Tetradecanedioic acid Uses

Tetradecanedioic acid (821-38-5) is used in a variety of industrial applications include:
Plasticizer for polymers
Biodegradable solvents and lubricants
Engineering plastics
Epoxy curing agent
Adhesive and powder coating
Corrosion inhibitor
Perfumery and pharmaceutical
Electrolyte

Tetradecanedioic acid Safety Profile

Hazard Codes: Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36: Wear suitable protective clothing

Tetradecanedioic acid Specification

1. Fire Fighting Measures
General Information: As in any fire, Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
2. Handling and Storage
Handling: Wash thoroughly after handling. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage: Store in a cool, dry place. Store in a tightly closed container.

Product Name

Tetradecanedioic acid

Synthetic route

Tetradecanedioic acid Chemical Properties

Tetradecanedioic acid Uses

Tetradecanedioic acid Safety Profile

Tetradecanedioic acid Specification

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