Tetrahydro pyrrole supplier

Name
Tetrahydro pyrrole
EINECS 204-648-7
CAS No. 123-75-1
Article Data313
CAS DataBase
Density 0.866 g/cm³
Solubility Miscible with water
Melting Point -63 °C, 210 K, -81 °F
Formula C₄H₉N
Boiling Point 89.451 °C at 760 mmHg
Molecular Weight 71.1222
Flash Point 2.778 °C
Transport Information UN 1922 3/PG 2
Appearance Colourless to pale yellow liquid
Safety 16-26-36/37/39-45-33
Risk Codes 11-22-23-34-35-20/21/22-20/22
Molecular Structure
Hazard Symbols F,T,C
Synonyms Pyrrolidin;Tetramethylenimine;Pyrrolidine ring;Perhydropyrrole;Pyrrole, tetrahydro-;2,3,4,5-Tetrahydropyrrole;Azacyclopentane;Butylenimine;Pyrrolidine (Tetrahydropyrrole);Pyrrolidine 99%;Pyrrolidine;Prolamine;
PSA 12.03000
LogP 0.69860

Synthetic route

: 109-97-7
pyrrole

: 123-75-1
pyrrolidine

Conditions

Conditions	Yield
With 5% Ru/MgO; hydrogen In tetrahydrofuran at 150℃; under 38002.6 Torr; for 0.7h;	100%
With dichloro(μ-chloro)(μ-hydrido)bis(η-p-cymene)diruthenium(II); hydrogen In neat (no solvent) at 90℃; under 60006 Torr; for 40h;	89%
With Cp*Rh(2-(2-pyridyl)phenyl)H; hydrogen In neat (no solvent) at 100℃; under 27361.8 Torr; for 48h; Catalytic behavior; Glovebox;	74%

: 56475-80-0
N-(methoxycarbonyl)pyrrolidine

: 123-75-1
pyrrolidine

Conditions

Conditions	Yield
With tert-butylamine In methanol for 3h; Heating;	100%
With methyllithium; lithium bromide In tetrahydrofuran at 0℃; for 1h;	95%

: 78521-30-9
1-(pyrrolidinyl)-2,4-dinitronaphthalene

: 74-89-5
methylamine

A: 123-75-1
pyrrolidine

B: 39139-78-1
1-(Methylamino)-2,4-dinitronaphthalene

Conditions

Conditions	Yield
In water at 30℃; for 1h;	A n/a B 98%

...Expand

: 616-45-5
2-pyrrolidinon

: 123-75-1
pyrrolidine

Conditions

Conditions	Yield
With methanesulfonic acid; ruthenium(1,1,1-tris(di(3,5-dimethylphenyl)phosphinomethyl)ethane)(η4-trimethylenemethane); hydrogen In tetrahydrofuran at 160℃; under 75007.5 Torr; for 16h; Autoclave; Schlenk technique;	98%
With tris(pentafluorophenyl)borate; C21H35BrMnNO2P2; potassium tert-butylate; hydrogen In m-xylene at 150℃; under 37503.8 Torr; for 72h;	81%
With borane-ammonia complex; boron trifluoride diethyl etherate; tris(pentafluorophenyl)borate In 1,2-dichloro-ethane at 60℃; for 16h;	77%

: 110-60-1
1,4-diaminobutane

: 123-75-1
pyrrolidine

Conditions

Conditions	Yield
HZSM-5(280) zeolite In water at 300℃; Cyclization;	97%
tris(triphenylphosphine)ruthenium(II) chloride In diphenylether at 180℃; for 5h; Product distribution; other α,ω-aliphatic diamines;	90%
With carbonylchloro[4,5-bis(diisopropylphosphinomethyl)acridine]hydridoruthenium(II) In 1,4-dioxane; water at 100℃; for 22h; Schlenk technique; Inert atmosphere;	88%

: 123477-57-6
pyrrolidine-1-carboxylic acid prop-2-ynyl ester

: 123-75-1
pyrrolidine

Conditions

Conditions	Yield
With benzyltriethylammonium tetrathiomolybdate In acetonitrile at 20℃; for 2.5h;	97%

: 110-63-4
Butane-1,4-diol

: 123-75-1
pyrrolidine

Conditions

Conditions	Yield
With ammonia; hydrogen; CuO/ZnO/Al2O3 at 220℃; under 26252.1 Torr;	94%
With aluminum oxide; ammonia at 400℃;
With aluminum oxide; ammonia at 325℃;

: 5470-26-8
ethyl pyrrolidine-1-carboxylate

: 123-75-1
pyrrolidine

Conditions

Conditions	Yield
With methyllithium; lithium bromide In tetrahydrofuran at 0℃; for 1h;	94%

: 142653-70-1
1-(9-fluorenylmethoxycarbonyl)pyrrolidine

: 123-75-1
pyrrolidine

Conditions

Conditions	Yield
With triethylamine; 1-butyl-3-methylimidazolium Tetrafluoroborate In neat (no solvent) at 25℃; for 0.0666667h; Green chemistry;	93%

: 29897-82-3
N-benzylpyrrolidine

: 123-75-1
pyrrolidine

Conditions

Conditions	Yield
With 9,10-Dicyanoanthracene In water; acetonitrile Irradiation;	90%

: 13325-10-5
4-Aminobutanol

: 123-75-1
pyrrolidine

Conditions

Conditions	Yield
With carbonylchloro[4,5-bis(diisopropylphosphinomethyl)acridine]hydridoruthenium(II) In 1,4-dioxane; water at 100℃; for 10h; Schlenk technique; Inert atmosphere;	88%
With aluminum oxide; nitrogen at 400℃;
dihydridotetrakis(triphenylphosphine)ruthenium In neat (no solvent) at 155℃; for 24h;	79 % Chromat.

: C13H14BrN3O3

A: 123-75-1
pyrrolidine

B: 80166-90-1
5-Bromo-7-nitroindoline

Conditions

Conditions	Yield
With water In 1,4-dioxane; dichloromethane at 20℃; for 12h; UV-irradiation;	A 88% B n/a

: 86953-79-9
tert-butyl pyrrolidine-1-carboxylate

A: 123-75-1
pyrrolidine

B: 115-11-7
isobutene

Conditions

Conditions	Yield
With methanesulfonic acid In tetrahydrofuran at 45℃; Solvent; Temperature;	A 83% B n/a
With cyclohexene at 260.9℃; under 44 Torr; Kinetics; Further Variations:; Pressures; Temperatures;

: 930-55-2
N-nitrosopyrrolidine

: 123-75-1
pyrrolidine

Conditions

Conditions	Yield
With isocyanate de chlorosulfonyle In diethyl ether for 10h; Ambient temperature;	78%

: 67-56-1
methanol

: 57671-12-2
N-(4-methylphenylsulfinyl)pyrrolidine

A: 123-75-1
pyrrolidine

B: 672-78-6
methyl p-toluene sulfinate

Conditions

Conditions	Yield
With tetraethylammonium tosylate Electrochemical reaction; reticulated vitreous carbon anode; Pt cathode;	A n/a B 75%

...Expand

: C20H22NO2S(1+)*BF4(1-)

A: 123-75-1
pyrrolidine

B: 766-92-7
[(methylthio)methyl]-benzene

C: 19532-98-0
N1,N2-dimethylphthalamide

Conditions

Conditions	Yield
With methylamine at 30℃; for 20h;	A n/a B 74% C n/a

...Expand

: 110-63-4
Butane-1,4-diol

A: 123-75-1
pyrrolidine

B: 767-10-2
1-butylpyrrolidine

C: 93264-47-2
4-(pyrrolidin-1-yl)butan-1-ol

D: 41726-75-4
1,4-di-(1-pyrrolidinyl)butane

E: 109-73-9
N-butylamine

Conditions

Conditions	Yield
With ammonia; hydrogen; iron RFC at 260℃; Product distribution; Mechanism; other temp. (280, 300, 310 deg C);	A 71% B 12% C n/a D n/a E 9%

...Expand

: C17H22NO2S(1+)*BF4(1-)

A: 123-75-1
pyrrolidine

B: 1613-51-0
sulfure de pentamethylene

C: 19532-98-0
N1,N2-dimethylphthalamide

Conditions

Conditions	Yield
With methylamine at 30℃; for 20h;	A n/a B 71% C n/a

...Expand

: C20H30NO2S(1+)*BF4(1-)

A: 123-75-1
pyrrolidine

B: 544-40-1
Dibutyl sulfide

C: 19532-98-0
N1,N2-dimethylphthalamide

Conditions

Conditions	Yield
With methylamine at 30℃; for 20h;	A n/a B 70% C n/a

...Expand

: 73722-93-7
C6H12NO(1+)*CH3O4S(1-)

A: 123-75-1
pyrrolidine

B: 3760-54-1
1-pyrrolidinecarboxaldehyde

C: 930-55-2
N-nitrosopyrrolidine

Conditions

Conditions	Yield
With sodium nitrite In water	A n/a B 70% C n/a

...Expand

: 123-75-1
pyrrolidine

: 108-30-5
succinic acid anhydride

: 69338-35-8
4-oxo-4-(1-pyrrolidinyl)butanoic acid

Conditions

Conditions	Yield
In acetonitrile at 20℃;	100%
In chloroform for 1h; Heating;	83%
With diethyl ether
Reflux;
In toluene for 2.5h; Reflux;

: 123-75-1
pyrrolidine

: 764-85-2
Nonanoyl chloride

: 20308-70-7
1-(pyrrolidin-1-yl)nonan-1-one

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 14h; Inert atmosphere;	100%
With diethyl ether; triethylamine

: 123-75-1
pyrrolidine

: 38460-95-6
undec-10-enoyl chloride

: 95018-99-8
1-(pyrrolidin-1-yl)undec-10-en-1-one

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 14h; Inert atmosphere;	100%
With triethylamine In dichloromethane at 0 - 23℃; for 14h;	100%
With triethylamine In dichloromethane at 0 - 23℃; for 14h;	100%

: 123-75-1
pyrrolidine

: 601-57-0
Cholest-4-en-3-one

: 2309-31-1
1-cholesta-3,5-dien-3-yl-pyrrolidine

Conditions

Conditions	Yield
In benzene for 24h; Heating;	100%
In benzene	100%
	93%

: 123-75-1
pyrrolidine

: 286-20-4
cyclohexane-1,2-epoxide

: 69420-67-3
(+/-)-trans-[2-(pyrrolidinyl)]cyclohexanol

Conditions

Conditions	Yield
for 114h; Heating;	100%
With lithium bromide at 20℃; for 2h;	100%
With zinc(II) perchlorate hexahydrate at 80℃; for 1h;	100%

: 123-75-1
pyrrolidine

: 108-94-1
cyclohexanone

: 1125-99-1
1-(1-Cyclohexen-1-yl)pyrrolidine

Conditions

Conditions	Yield
In toluene for 18h; Molecular sieve; Dean-Stark trap; Heating / reflux;	100%
With sulfuric acid In toluene Dean-Stark; Reflux;	99%
With K-10 Montmorillonite clay In toluene for 2.5h; Heating;	95%

: 123-75-1
pyrrolidine

: 100-00-5
4-chlorobenzonitrile

: 10220-22-1
1-(4-nitro-phenyl)-pyrrolidine

Conditions

Conditions	Yield
In tetrahydrofuran at 50℃; under 4500360 Torr; for 20h;	100%
In tetrahydrofuran at 50℃; under 6000 Torr; for 2h; Product distribution; other pressure;	100%
at 108℃; for 2h; Neat (no solvent);	98%

: 123-75-1
pyrrolidine

: 292638-85-8
acrylic acid methyl ester

: 22041-21-0
methyl 3-(pyrrolidin-1-yl)propanoate

Conditions

Conditions	Yield
With zirconium(IV) chloride In dichloromethane at 20℃; for 0.75h; Michael addition;	100%
With silica-supported aluminum chloride at 60℃; for 2h; Michael addition; Neat (no solvent);	100%
In dichloromethane at 0 - 20℃; for 2h;	100%

: 123-75-1
pyrrolidine

: 79-04-9
chloroacetyl chloride

: 20266-00-6
chloroacetic acid pyrrolidide

Conditions

Conditions	Yield
In acetone at 20℃;	100%
In tetrahydrofuran at 0 - 20℃; for 3.5h;	99%
In tetrahydrofuran at 20℃; for 12h; Acylation;	98%

: 123-75-1
pyrrolidine

: 103-80-0
phenylacetyl chloride

: 3389-53-5
phenylacetylpyrrolidine

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃;	100%
With triethylamine In dichloromethane at 20℃; for 14h; Inert atmosphere;	100%
With triethylamine In dichloromethane at 20℃;	92%

: 123-75-1
pyrrolidine

: 3760-55-2
1-nitropyrrolidine

Conditions

Conditions	Yield
With 2-(trifluoromethyl)-2-propyl nitrate at 50℃; for 168h;	100%
With nitronium trifluoromethanesulfonate In dichloromethane at -20℃; for 1h;	43%
With tetrachloromethane; dinitrogen pentoxide
With butyl nitrate; ethylmagnesium bromide 1.) benzene, 15 min, 2.) benzene, 0.5 h; Yield given. Multistep reaction;

: 123-75-1
pyrrolidine

: 285-67-6
Cyclopentene oxide

: 32635-39-5
(+/-)-trans-(1-pyrrolidinyl)cyclopentan-2-ol

Conditions

Conditions	Yield
bismuth(lll) trifluoromethanesulfonate at 160℃; for 0.25h; microwave irradiation;	100%
With triethylaluminum 1.) toluene, CH2Cl2, 25-30 deg C, 30 min, 2.) room temperature; Yield given. Multistep reaction;
In water
With potassium carbonate
In ethanol at 80℃; for 18h; Inert atmosphere;

: 123-75-1
pyrrolidine

: 96-48-0
4-butanolide

: 73200-24-5
4-hydroxy-1-(pyrrolidin-1-yl)butan-1-one

Conditions

Conditions	Yield
With triethylamine Inert atmosphere; Reflux;	100%
With triethylamine for 16h; Reflux;	94%
In benzene for 3h; Heating;	90%

: 123-75-1
pyrrolidine

: 542-28-9
3,4,5,6-tetrahydro-2H-pyran-2-one

: 73200-35-8
5-hydroxy-1-(pyrrolidin-1-yl)pentan-1-one

Conditions

Conditions	Yield
With triethylamine Inert atmosphere; Reflux;	100%
In benzene	82%

: 123-75-1
pyrrolidine

: 103-82-2
phenylacetic acid

: 3389-53-5
phenylacetylpyrrolidine

Conditions

Conditions	Yield
Stage #1: phenylacetic acid With 4-iodofuran-3-yl-boronic acid In dichloromethane for 0.166667h; Molecular sieve 4Å; Stage #2: pyrrolidine In dichloromethane at 25℃; for 6h; Product distribution / selectivity;	100%
With 4 A molecular sieve at 150℃; for 2h;	98%
With tetramethylorthosilicate In toluene at 110℃; for 1h; Inert atmosphere;	98%

: 123-75-1
pyrrolidine

: 636-98-6
p-nitrobenzene iodide

: 10220-22-1
1-(4-nitro-phenyl)-pyrrolidine

Conditions

Conditions	Yield
In tetrahydrofuran at 50℃; under 9000720 Torr; for 20h;	100%
With copper(l) iodide; 1-(5,6,7,8-tetrahydroquinolin-8-yl)ethan-1-one; caesium carbonate In N,N-dimethyl-formamide at 25℃; for 24h; Ullmann condensation; Inert atmosphere;	95%
With copper(l) iodide In N,N-dimethyl acetamide at 130℃; for 24h;	95%

: 123-75-1
pyrrolidine

: 72553-83-4
1-Chlor-4-phenyl-pyridazino<4,5-d>pyridazin

: 83490-50-0
1-Pyrrolidino-4-phenyl-pyridazino<4,5-d>pyridazin

Conditions

Conditions	Yield
for 3h; Heating;	100%

: 123-75-1
pyrrolidine

: 74151-83-0
6'-chloro-1,3,1',3'-tetramethyl-3H,1'H-[4,5']bipyrimidinyl-2,6,2',4'-tetraone

: 1,3,1',3'-Tetramethyl-6-pyrrolidin-1-yl-1H,1'H-[5,5']bipyrimidinyl-2,4,2',4'-tetraone

Conditions

Conditions	Yield
	100%

: 123-75-1
pyrrolidine

: 2033-24-1
cycl-isopropylidene malonate

: 96-17-3, 57456-98-1
2-Methylbutyraldehyde

: 2,2-Dimethyl-5-(2-methyl-1-pyrrolidin-1-yl-butyl)-[1,3]dioxane-4,6-dione

Conditions

Conditions	Yield
In diethyl ether for 0.166667h;	100%

...Expand

: 123-75-1
pyrrolidine

: 2033-24-1
cycl-isopropylidene malonate

: 123-05-7
d,l-2-ethylhexanal

: 93498-12-5
5-(2-Ethyl-1-pyrrolidin-1-yl-hexyl)-2,2-dimethyl-[1,3]dioxane-4,6-dione

Conditions

Conditions	Yield
In diethyl ether for 0.166667h;	100%

...Expand

: 123-75-1
pyrrolidine

: 2033-24-1
cycl-isopropylidene malonate

: 100-52-7
benzaldehyde

: 93498-11-4
2,2-Dimethyl-5-(phenyl-pyrrolidin-1-yl-methyl)-[1,3]dioxane-4,6-dione

Conditions

Conditions	Yield
In diethyl ether for 0.166667h;	100%

...Expand

: 123-75-1
pyrrolidine

: 2033-24-1
cycl-isopropylidene malonate

: 123-38-6
propionaldehyde

: 93498-07-8
2,2-Dimethyl-5-(1-pyrrolidin-1-yl-propyl)-[1,3]dioxane-4,6-dione

Conditions

Conditions	Yield
In diethyl ether for 0.166667h;	100%

...Expand

: 123-75-1
pyrrolidine

: 2033-24-1
cycl-isopropylidene malonate

: 123-72-8
butyraldehyde

: 93498-08-9
2,2-Dimethyl-5-(1-pyrrolidin-1-yl-butyl)-[1,3]dioxane-4,6-dione

Conditions

Conditions	Yield
In diethyl ether for 0.166667h;	100%

...Expand

: 123-75-1
pyrrolidine

: 2033-24-1
cycl-isopropylidene malonate

: 78-84-2
isobutyraldehyde

: 93498-09-0
2,2-Dimethyl-5-(2-methyl-1-pyrrolidin-1-yl-propyl)-[1,3]dioxane-4,6-dione

Conditions

Conditions	Yield
In diethyl ether for 0.166667h;	100%

...Expand

: 123-75-1
pyrrolidine

: 50-00-0
formaldehyd

: 142238-04-8
1-acetyl-3-(2-propynyl)-2-imidazolidone

: 142237-98-7
1-Acetyl-3-(4-pyrrolidin-1-yl-but-2-ynyl)-imidazolidin-2-one

Conditions

Conditions	Yield
With acetic acid; copper(l) chloride In 1,4-dioxane at 50℃; for 4h;	100%

...Expand

: 123-75-1
pyrrolidine

: 1008-76-0
4,5-dihydro-5-phenyl-2(3H)-furanone

: 99802-88-7
4-hydroxy-4-phenyl-1-(pyrrolidine-1-yl)butan-1-one

Conditions

Conditions	Yield
With triethylamine Reflux; Inert atmosphere;	100%
With triethylamine for 72h; Schlenk technique; Reflux;	97%
In water for 4h; Heating;	90%

: 123-75-1
pyrrolidine

: 5911-65-9
5,6,9,10,11,11a-Hexahydro-2,3-dimethoxy-8,10-dioxo-8H-benzoquinolizine

: 85222-89-5
5,6,11,11a-Tetrahydro-2,3-dimethoxy-8-oxo-10-(1-pyrrolidinyl)-8H-benzoquinolizine

Conditions

Conditions	Yield
In benzene for 1h; Heating;	100%

: 123-75-1
pyrrolidine

: 18410-00-9
7α,11β-eudesm-4-en-12,6α-olide

: (S)-2-((1S,2S,4aR)-1-Hydroxy-4a,8-dimethyl-1,2,3,4,4a,5,6,7-octahydro-naphthalen-2-yl)-1-pyrrolidin-1-yl-propan-1-one

Conditions

Conditions	Yield
In benzene for 30h; Ambient temperature;	100%

: 123-75-1
pyrrolidine

: 10180-76-4, 42807-16-9, 42807-20-5, 62870-77-3, 70469-41-9, 96987-20-1
Sant-3-enolid

: (S)-2-((1S,2S,4aR)-1-Hydroxy-4a,8-dimethyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-2-yl)-1-pyrrolidin-1-yl-propan-1-one

Conditions

Conditions	Yield
In benzene for 18h; Ambient temperature;	100%

Tetrahydro pyrrole Consensus Reports

Reported in EPA TSCA Inventory.

Tetrahydro pyrrole Standards and Recommendations

DOT Classification: 3;
Label: Flammable Liquid

Tetrahydro pyrrole Specification

The Pyrrolidine with CAS registry number of 123-75-1 is also known as Tetrahydropyrrole. The IUPAC name and product name are the same. It belongs to product categories of Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines; Flavor. Its EINECS registry number is 204-648-7. In addition, the formula is C₄H₉N and the molecular weight is 71.12. This chemical is a colourless to pale yellow liquid and should be sealed in dark place.

Physical properties about Pyrrolidine are: (1)ACD/LogP: 0.09; (2)ACD/BCF (pH 5.5): 1; (3)ACD/BCF (pH 7.4): 1; (4)ACD/KOC (pH 5.5): 1; (5)ACD/KOC (pH 7.4): 1; (6)#H bond acceptors: 1; (7)#H bond donors: 1; (8)Index of Refraction: 1.428; (9)Molar Refractivity: 21.795 cm³; (10)Molar Volume: 84.749 cm³; (11)Surface Tension: 26.891 dyne/cm; (12)Density: 0.839 g/cm³; (13)Flash Point: 2.778 °C; (14)Enthalpy of Vaporization: 33.01 kJ/mol; (15)Boiling Point: 89.451 °C at 760 mmHg; (16)Vapour Pressure: 58.582 mmHg at 25 °C.

Preparation of Pyrrolidine: it is prepared by reaction of maleic anhydride. Product is obtained by hydrogenation and amination.

Pyrrolidine is prepared by reaction of maleic anhydride.

Uses of Pyrrolidine: it is used to produce 1-prop-2-ynyl-pyrrolidine by reaction with 3-bromo-propyne. The reaction occurs with reagents KOH, alumina and solvent aliquat 336 at 20 °C. The yield is about 55%. Besides, it is also used as pharmaceutical raw materials, organic synthesis and special organic solvent.

Pyrrolidine is used to produce 1-prop-2-ynyl-pyrrolidine by reaction with 3-bromo-propyne.

When you are using this chemical, please be cautious about it. As a chemical, it is harmful by inhalation, in contact with skin and if swallowed. It is highly flammable and may cause severe burns. During using it, wear suitable protective clothing, gloves and eye/face protection. Take precautionary measures against static discharges and keep away from sources of ignition. If contact with eyes accidently, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
1. Canonical SMILES: C1CCNC1
2. InChI: InChI=1S/C4H9N/c1-2-4-5-3-1/h5H,1-4H2
3. InChIKey: RWRDLPDLKQPQOW-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LDLo	oral	250mg/kg (250mg/kg)		"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 104, 1982.
mammal (species unspecified)	LD50	oral	250mg/kg (250mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 39(4), Pg. 86, 1974.
mouse	LC50	inhalation	1300mg/m³/2H (1300mg/m³)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT VASCULAR: OTHER CHANGES	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 18(2), Pg. 29, 1974.
mouse	LD50	intraperitoneal	420mg/kg (420mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 88, Pg. 82, 1946.
mouse	LD50	intravenous	56mg/kg (56mg/kg)		U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#06769,
mouse	LD50	oral	450mg/kg (450mg/kg)		Bollettino Chimico Farmaceutico. Vol. 103, Pg. 414, 1964.
rabbit	LDLo	oral	250mg/kg (250mg/kg)		"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 104, 1982.
rat	LD50	oral	300mg/kg (300mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT VASCULAR: OTHER CHANGES	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 18(2), Pg. 29, 1974.

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