Tributyl phosphate supplier

Name
Tributyl phosphate
EINECS 204-800-2
CAS No. 126-73-8
Article Data121
CAS DataBase
Density 0.986 g/cm³
Solubility 0.6 g/100 mL in water
Melting Point -79 °C
Formula C₁₂H₂₇O₄P
Boiling Point 288.3 °C at 760 mmHg
Molecular Weight 266.318
Flash Point 193.3 °C
Transport Information UN 1208 3/PG 2
Appearance clear liquid
Safety 36/37-46-45-36/37/39-16-53
Risk Codes 22-38-40-62-48/20-36/37/38-11
Molecular Structure
Hazard Symbols Xn,F
Synonyms Tributilfosfato;Celluphos 4;Butyl phosphate, tri-;1-dibutoxyphosphoryloxybutane;Butyl phosphate, ((BuO)3PO);Phosphoric acid tributyl ester;Tributyle (phosphate de)(FRENCH);Tributylfosfaat;Disflamoll TB;Tributoxyphosphine oxide;TBP;Tributylphosphat;Tri-n-butyl phosphate;Butyl phosphate;TBP Tributyl phosphate;Tributyl phosphate (TBP);
PSA 54.57000
LogP 4.54460

Synthetic route

: 71-36-3
butan-1-ol

: 126-73-8
phosphoric acid tributyl ester

Conditions

Conditions	Yield
With oxygen; phosphan; copper dichloride at 24.9℃; Rate constant; Product distribution; other acohols and reagents, var. concentration of reagents and temperatures;	100%
With oxygen; phosphan; copper dichloride at 24.9℃;	100%
With oxygen; copper dichloride at 59.9℃;	100%

: 71-36-3
butan-1-ol

A: 126-73-8
phosphoric acid tributyl ester

B: 109-69-3
n-Butyl chloride

Conditions

Conditions	Yield
With hydrogenchloride; water; oxygen; copper dichloride at 59.9℃; Product distribution; Mechanism; other alcohols, var. conc. of reagents, var. temperat.;	A 100% B n/a
With phosphan; chlorine Rate constant; Thermodynamic data; Ea, ΔS(excit.); also in the presence of pyridine;

: 2372-45-4
sodium butanolate

: 126-73-8
phosphoric acid tributyl ester

Conditions

Conditions	Yield
With trichlorophosphate In butan-1-ol at 10 - 30℃; for 1.83333h;	98%
With diethyl ether; trichlorophosphate; butan-1-ol at 0℃;

: 71-36-3
butan-1-ol

A: 1809-19-4
dibutyl hydrogen phosphite

B: 126-73-8
phosphoric acid tributyl ester

Conditions

Conditions	Yield
With sodium hypophosphite; copper dichloride at 24.9℃; for 214h;	A 5.5% B 94.5%
With hydrogenchloride; zinc(II) phosphide; iron(III) chloride at 70℃;	A 90% B 9%
With sodium hypophosphite; copper dichloride at 24.9℃; for 173h;	A 16.7% B 87.3%

: 78-47-7
O,O,O-tributyl phosphorothioate

: 126-73-8
phosphoric acid tributyl ester

Conditions

Conditions	Yield
With ozone In dichloromethane at -75℃;	92%

: 71-36-3
butan-1-ol

A: 126-73-8
phosphoric acid tributyl ester

B: 109-69-3
n-Butyl chloride

C: 142-96-1
dibutyl ether

Conditions

Conditions	Yield
With oxygen; phosphan; copper(l) chloride; copper dichloride at 24.9℃; Kinetics; Product distribution; Mechanism; ΔE(excit.), ΔS(excit.); other reagents, other catalysts;	A 90% B n/a C n/a
With oxygen; phosphan; copper(l) chloride; copper dichloride at 24.9℃;	A 90% B n/a C n/a

...Expand

: 71-36-3
butan-1-ol

A: 1623-15-0
n-butyl phosphoric acid

B: 126-73-8
phosphoric acid tributyl ester

C: 107-66-4
dibutyl phosphate

Conditions

Conditions	Yield
With phosphorus; tetraethylammonium iodide In water; acetonitrile electrolysis;	A n/a B 87% C n/a

...Expand

: 542-69-8
1-iodo-butane

: 107-66-4
dibutyl phosphate

: 126-73-8
phosphoric acid tributyl ester

Conditions

Conditions	Yield
With cesium fluoride In acetonitrile for 6h; Ambient temperature; also with n-butylbromide;	86%

: 71-36-3
butan-1-ol

A: 126-73-8
phosphoric acid tributyl ester

B: 72095-77-3
butylbis(α-hydroxybutyl)phosphine oxide

Conditions

Conditions	Yield
With phosphan; p-benzoquinone at 80℃; Kinetics; Condensation; oxidation;	A 15% B 85%

: 71-36-3
butan-1-ol

A: 126-73-8
phosphoric acid tributyl ester

B: 107-66-4
dibutyl phosphate

Conditions

Conditions	Yield
With sodium bromate; phosphan at 80℃; Kinetics; Condensation;	A 20% B 80%
With sodium hypophosphite; copper dichloride at 24.9℃; for 4h;	A 22.2% B 77.8%
With phosphorous; air; ruthenium hydroxide trichloride; copper dichloride at 80℃; oxidative alkoxylation;	A 33.7% B 11.3%

: 1809-19-4
dibutyl hydrogen phosphite

: 71-36-3
butan-1-ol

: 126-73-8
phosphoric acid tributyl ester

Conditions

Conditions	Yield
With sodium hydroxide; tetrabutylammomium bromide In tetrachloromethane; dichloromethane at 15℃; for 3h;	71.6%

: 102-85-2
tri-n-butyl phosphite

A: 625-22-9
sulfuric acid dibutyl ester

B: 126-73-8
phosphoric acid tributyl ester

C: 78-46-6
dibutyl butylphosphonate

Conditions

Conditions	Yield
With sulfur trioxide In dichloromethane at -50℃;	A 28% B 70% C 2%

...Expand

: 102-85-2
tri-n-butyl phosphite

: 4128-31-8
rac-octan-2-ol

A: 126-73-8
phosphoric acid tributyl ester

B: Phosphoric acid dibutyl ester 1-methyl-heptyl ester

Conditions

Conditions	Yield
With lutidine; tellurium tetrachloride In dichloromethane for 3h; Ambient temperature;	A 30% B 70%

...Expand

: 102-85-2
tri-n-butyl phosphite

A: 625-22-9
sulfuric acid dibutyl ester

B: 126-73-8
phosphoric acid tributyl ester

C: 78-47-7
O,O,O-tributyl phosphorothioate

D: 78-46-6
dibutyl butylphosphonate

Conditions

Conditions	Yield
With sulfur trioxide In dichloromethane at -50℃;	A 2% B 64% C 22% D 12%

...Expand

: 71-36-3
butan-1-ol

A: 126-73-8
phosphoric acid tributyl ester

B: 78-46-6
dibutyl butylphosphonate

Conditions

Conditions	Yield
With phosphorous; tetraethylammonium iodide In acetonitrile at 56℃; electrolysis;	A 60% B 15%
With phosphorous In acetonitrile at 56℃; Electrolysis;	A 60% B 15%

: 71-36-3
butan-1-ol

A: 126-73-8
phosphoric acid tributyl ester

B: 1474-75-5
n-butyl pyrophosphate

Conditions

Conditions	Yield
With tetraethylammonium iodide; water In acetonitrile at 55℃; electrosynthesis;	A 16% B 51%

: 102-85-2
tri-n-butyl phosphite

A: 1809-19-4
dibutyl hydrogen phosphite

B: 126-73-8
phosphoric acid tributyl ester

Conditions

Conditions	Yield
With HOF* CH3CN In dichloromethane at 0℃; for 0.0833333h;	A 50% B 40%

: 102-85-2
tri-n-butyl phosphite

: 122-97-4
3-Phenyl-1-propanol

A: 126-73-8
phosphoric acid tributyl ester

B: 144357-50-6
dibutyl 3-phenylpropyl phosphate

C: 144357-51-7
butyl bis(3-phenylpropyl) phosphate

Conditions

Conditions	Yield
Stage #1: tri-n-butyl phosphite; 3-Phenyl-1-propanol With 1H-tetrazole In dichloromethane at 20℃; for 22h; transesterification; Stage #2: With 3-chloro-benzenecarboperoxoic acid In dichloromethane at -78 - 20℃; for 0.5h; Oxidation;	A 21% B 36% C 16%
With 1H-tetrazole; 3-chloro-benzenecarboperoxoic acid multistep reaction: transesterification of trialkyl phosphites with an alcohol;
With 1H-tetrazole; 3-chloro-benzenecarboperoxoic acid 1) CH2Cl2, room temperature, 22 h; Yield given. Multistep reaction. Yields of byproduct given;

...Expand

: 102-85-2
tri-n-butyl phosphite

: 126-73-8
phosphoric acid tributyl ester

Conditions

Conditions	Yield
With Cumene hydroperoxide In benzene at 20℃; Rate constant;
With dinitrogen tetraoxide im Stickstoff-Strom;
With nitrosylchloride anschliessenden Erhitzen auf 150grad;

: 3085-30-1
aluminum tri-n-butoxide

: 126-73-8
phosphoric acid tributyl ester

Conditions

Conditions	Yield
With trichlorophosphate; benzene

: 107-66-4
dibutyl phosphate

: 126-73-8
phosphoric acid tributyl ester

Conditions

Conditions	Yield
With sodium hydroxide at 255℃;

: 67-56-1
methanol

: 102-85-2
tri-n-butyl phosphite

A: 7242-59-3
dibutyl methyl phosphate

B: 126-73-8
phosphoric acid tributyl ester

Conditions

Conditions	Yield
With oxygen; methylene blue In acetonitrile at 20℃; for 0.166667h; Mechanism; Product distribution; Irradiation; without methanol; other reaction time; also in the presence of diphenyl sulfides or sulfoxides as trapping agents of intermediates;	A n/a B 73 % Chromat.

...Expand

: 102-85-2
tri-n-butyl phosphite

: 2375-33-9
chlorofluoronitromethane

A: 126-73-8
phosphoric acid tributyl ester

B: 109-69-3
n-Butyl chloride

C: 114192-97-1
C9H19FNO4P

D: 114192-96-0
C9H19FNO4P

Conditions

Conditions	Yield
at 50℃; for 2h; Title compound not separated from byproducts;

...Expand

: 102-85-2
tri-n-butyl phosphite

: 18057-16-4
trimethylsilyl(cumyl) peroxide

A: 1066-40-6
Trimethylsilanol

B: 126-73-8
phosphoric acid tributyl ester

C: 107-46-0
Hexamethyldisiloxane

D: 617-94-7
1-methyl-1-phenylethyl alcohol

E: 14629-57-3
1-phenyl-1-methyl-1-trimethylsiloxyethane

F: 98-86-2
acetophenone

Conditions

Conditions	Yield
In various solvent(s) at 343℃; Rate constant; Mechanism; Product distribution; E(activ.);

...Expand

: 102-85-2
tri-n-butyl phosphite

A: 126-73-8
phosphoric acid tributyl ester

B: 144357-50-6
dibutyl 3-phenylpropyl phosphate

C: 144357-51-7
butyl bis(3-phenylpropyl) phosphate

Conditions

Conditions	Yield
With 1H-tetrazole; 3-Phenyl-1-propanol; 3-chloro-benzenecarboperoxoic acid 1) CH2Cl2, room temperature, 22 h; Yield given. Multistep reaction. Yields of byproduct given;

...Expand

: 102-85-2
tri-n-butyl phosphite

A: 126-73-8
phosphoric acid tributyl ester

B: 819-43-2
dibutyl chlorophosphate

Conditions

Conditions	Yield
With sulfuryl dichloride at 20 - 30℃;	A 10 % Spectr. B 90 % Spectr.

: 71-36-3
butan-1-ol

: 819-43-2
dibutyl chlorophosphate

: 126-73-8
phosphoric acid tributyl ester

Conditions

Conditions	Yield
at 60℃; Rate constant; Thermodynamic data; activation energy, activation enthalpy, other temperature (40, 50, 70, 80 deg C);
at 60℃; Rate constant; other temperature (50, 80 deg C);

: 71-36-3
butan-1-ol

A: 126-73-8
phosphoric acid tributyl ester

B: 142-96-1
dibutyl ether

Conditions

Conditions	Yield
With phosphan; copper dichloride In N,N-dimethyl-formamide at 24.9℃; Rate constant; Thermodynamic data; ΔS(excit); reaction also with FeCl3;
With phosphan; copper dichloride In N,N-dimethyl-formamide at 59.9℃;
With oxygen; phosphan; copper(ll) bromide at 50℃; Catalytic behavior; Kinetics; Mechanism; Reagent/catalyst; Temperature;

: 1498-52-8
butyl dichlorophosphate

: 819-43-2
dibutyl chlorophosphate

: 126-73-8
phosphoric acid tributyl ester

Conditions

Conditions	Yield
at 20.1℃; Rate constant; Kinetics; var. molar ratios of edduct, temp., and solvents; also with HCl;

: 2372-45-4
sodium butanolate

: 266356-64-3
dibutyl (4,6-dimethyl-2-pyrimidyl) phosphate

A: 108-79-2
4,6-dimethylpirimidin-2-one

B: 126-73-8
phosphoric acid tributyl ester

Conditions

Conditions	Yield
In para-xylene at 140℃; for 2h; Product distribution; phosphorylation;

...Expand

: 126-73-8
phosphoric acid tributyl ester

: 109-65-9
1-bromo-butane

Conditions

Conditions	Yield
With salophen(tBu)AlBr In chloroform-d1 at 20℃; for 0.5 - 24h; Product distribution / selectivity;	100%
With (N,N'-ethylenebis(3,5-di-tert-butylsalicylideneimine))AlBr In chloroform-d1 at 20℃; for 0.5 - 24h; Product distribution / selectivity;	12%
With (N,N'-propylenebis(3,5-di-tert-butylsalicylideneimine))AlBr In chloroform-d1 at 20℃; for 0.5 - 24h; Product distribution / selectivity;	7%

: (N,N'-propylenebis(3,5-di-tert-butylsalicylideneimine))AlBr

: 126-73-8
phosphoric acid tributyl ester

: 890084-07-8
[(N,N'-propylenebis(3,5-di-tert-butylsalicylideneimine))AlO]2[(BuO)2PO]2

Conditions

Conditions	Yield
In toluene to soln. Al complex in toluene (BuO)3PO was added, stirred for 48 h; soln. was filtered, concd. and cooled to -30°C for several days, ppt. was filtered, washed with ether and hexane and dried in vacuo; elem. anal.;	100%

: 848906-02-5
1,2,3,4-tetramethylimidazolium methyl carbonate

: 126-73-8
phosphoric acid tributyl ester

: 1,2,3,4-tetramethylimidazolium dibutylphosphate

Conditions

Conditions	Yield
Stage #1: phosphoric acid tributyl ester With diethylamine at 125℃; for 70h; Stage #2: 1,2,3,4-tetramethylimidazolium methyl carbonate In methanol	99.5%

: 123-73-9
trans-Crotonaldehyde

: 126-73-8
phosphoric acid tributyl ester

: 24224-99-5
benzenesulfonyl cyanide

: 24244-60-8
2-(phenylsulfonyl)pyridine

Conditions

Conditions	Yield
In toluene; butan-1-ol	99%

...Expand

: 616-47-7
1-methyl-1H-imidazole

: 126-73-8
phosphoric acid tributyl ester

: 1-n-butyl-3-methylimidazolium dibutyl phosphate

Conditions

Conditions	Yield
at 170℃; for 5h;	98%
at 150℃; for 24h;	92%

: 126-73-8
phosphoric acid tributyl ester

: 5292-43-3
bromoacetic acid tert-butyl ester

: 103717-32-4
t-butyl-2-(dibutoxyphosphoryl)acetate

Conditions

Conditions	Yield
at 90℃; for 24h; Inert atmosphere;	98%

: 126-73-8
phosphoric acid tributyl ester

: 107-66-4
dibutyl phosphate

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water for 2.5h; Heating;	97%
With sodium hydroxide
With hydrogenchloride In hydrogenchloride byproducts: C4H9Cl; hydrolysis of TBP in concd. HCl;; hydrolytic decompn. of 18.5 % TBP in 6 days at ambient temp.;;
With HCl In hydrogenchloride byproducts: C4H9Cl; hydrolysis of TBP in concd. HCl;; hydrolytic decompn. of 18.5 % TBP in 6 days at ambient temp.;;

: 126-73-8
phosphoric acid tributyl ester

: 127-09-3
sodium acetate

: 123-86-4
acetic acid butyl ester

Conditions

Conditions	Yield
at 200 - 220℃; for 5h;	96%
Heating;

: 126-73-8
phosphoric acid tributyl ester

: 85355-10-8
sodium [2-13C,2H3]acetate

: 120388-51-4
butyl <2-13C,2H3>acetate

Conditions

Conditions	Yield
for 5h; Heating;	96%

: neodymium trifluoromethanesulfonate nonahydrate

: 126-73-8
phosphoric acid tributyl ester

: Nd(3+)*3CF3O3S(1-)*H2O*3C12H27O4P

Conditions

Conditions	Yield
In tetrahydrofuran at 90℃; for 8h;	95.1%

: 126-73-8
phosphoric acid tributyl ester

: 99-56-9
4-Nitrophenylene-1,2-diamine

: 4-nitro-2-benzimidazolone

Conditions

Conditions	Yield
With urea In 2-methylchlorobenzene; water	95%

: 2634-33-5
1,2-benzisothiazolin-3-one

: 126-73-8
phosphoric acid tributyl ester

: 4299-07-4
2-butyl-1,2-benzothiazolin-3-one

Conditions

Conditions	Yield
Stage #1: 1,2-benzisothiazolin-3-one With sodium methylate In methanol at 25℃; for 1h; Stage #2: phosphoric acid tributyl ester In methanol for 4h;	95%

: 109-72-8, 29786-93-4
n-butyllithium

: 126-73-8
phosphoric acid tributyl ester

: 78-46-6
dibutyl butylphosphonate

Conditions

Conditions	Yield
In tetrahydrofuran; hexane at -78 - 0℃;	94%

: 126-73-8
phosphoric acid tributyl ester

: 121-69-7
N,N-dimethyl-aniline

: dibutyl ((methyl(phenyl)amino)methyl)phosphonate

Conditions

Conditions	Yield
With sodium benzoate; tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; dichloro(dimethylglyoxime)(dimethylglyoximato)cobalt(III) In 1,2-dichloro-ethane; acetonitrile at 25℃; for 24h; Inert atmosphere; Schlenk technique; Irradiation;	94%

: 126-73-8
phosphoric acid tributyl ester

: neodymium(III) trifluoromethanesufonate

: Nd(CF3SO3)3*3TBP

Conditions

Conditions	Yield
at 120℃; for 12h; Inert atmosphere;	92.5%

: 126-73-8
phosphoric acid tributyl ester

: 92-77-3
2,3-oxynaphthoic acid phenylamide

: 762-42-5
dimethyl acetylenedicarboxylate

: dimethyl 2-(dibutoxyphosphoryl)-3-[2-hydroxy-3-(phenylcarbamoyl)naphthalen-1-yl]succinate

Conditions

Conditions	Yield
In acetone at 20℃; for 24h;	91%

...Expand

: 126-73-8
phosphoric acid tributyl ester

: 96-22-0
pentan-3-one

: 19780-41-7
3-ethylheptan-3-ol

Conditions

Conditions	Yield
With lithium In tetrahydrofuran at -30℃; for 0.25h;	90%

: 126-73-8
phosphoric acid tributyl ester

: 135-61-5
naphthol ASD

: 762-42-5
dimethyl acetylenedicarboxylate

: dimethyl 2-(dibutoxyphosphoryl)-3-[2-hydroxy-3-(2-methylphenylcarbamoyl)naphthalen-1-yl]succinate

Conditions

Conditions	Yield
In acetone at 20℃; for 24h;	90%

...Expand

: 111-87-5
octanol

: 126-73-8
phosphoric acid tributyl ester

: 53839-23-9
1-butoxyoctane

Conditions

Conditions	Yield
With iron(II) triflate In neat (no solvent) at 100℃;	90%

: 126-73-8
phosphoric acid tributyl ester

: 13291-89-9
[2-13C]-sodium acetate

: 121919-87-7
n-Butyl<2-(13)C>acetate

Conditions

Conditions	Yield
at 210℃; for 6h;	88%

: 126-73-8
phosphoric acid tributyl ester

: 100-52-7
benzaldehyde

: 583-03-9
1-Phenyl-1-pentanol

Conditions

Conditions	Yield
With lithium In tetrahydrofuran at -30℃; for 0.25h;	86%

: 126-73-8
phosphoric acid tributyl ester

: 104-15-4
toluene-4-sulfonic acid

: 778-28-9
butyl para-toluenesulfonate

Conditions

Conditions	Yield
In methyl cyclohexane for 72h; Heating;	86%

: 126-73-8
phosphoric acid tributyl ester

: 104-15-4
toluene-4-sulfonic acid

: 108-88-3
toluene

A: 778-28-9
butyl para-toluenesulfonate

B: 1595-16-0
1-sec-butyl-4-methylbenzene

C: 1595-06-8, 88329-15-1
2-sec-butyltoluene

Conditions

Conditions	Yield
In methyl cyclohexane for 72h; Product distribution; Heating; investigate effect of molar ratio, solvent and reaction time;	A 86% B n/a C n/a

...Expand

Tributyl phosphate Consensus Reports

Reported in EPA TSCA Inventory.

Tributyl phosphate Standards and Recommendations

OSHA PEL: TWA 0.2 ppm
ACGIH TLV: TWA 0.2 ppm

Tributyl phosphate Analytical Methods

For occupational chemical analysis use NIOSH: Tributyl Phosphate, S208.

Tributyl phosphate Specification

1. Introduction of Tributyl phosphate
Tributyl phosphate, with CAS number of 126-73-8, can be called Tributilfosfato; Celluphos 4 ; Butyl phosphate, tri-; 1-dibutoxyphosphoryloxybutane; Butyl phosphate; Phosphoric acid tributyl ester; tributyl ester; Tributoxyphosphine oxide; TBP Tributyl phosphate; Tributyl phosphate (TBP). Tributyl phosphate, known commonly as TBP, is a solvent and plasticizer for cellulose esters such as nitrocellulose and cellulose acetate. The major uses of TBP in industry are as a component of aircraft hydraulic fluid and as a solvent for extraction and purification of rare earth metals from their ores. Tributyl phosphate is used also in mercerizing liquids, where it improves their wetting properties. Tributyl phosphate is also used as a heat exchange medium. TBP is used in some consumer products such as herbicides and water thinned paints and tinting bases.

2. Properties of Tributyl phosphate
H bond acceptors: 4
H bond donors: 0
Freely Rotating Bonds: 12
Polar Surface Area: 54.57Å2
Index of Refraction: 1.43
Molar Refractivity: 69.75 cm³Molar Volume: 269.8 cm³Surface Tension: 31.7 dyne/cm
Density: 0.986 g/cm³Flash Point: 193.3 °C
Enthalpy of Vaporization: 50.64 kJ/mol
Boiling Point: 288.3 °C at 760 mmHg
Vapour Pressure: 0.00409 mmHg at 25°C
Melting point: -79 °C
Water Solubility: 0.6 g/100 mL
Merck :14,9618
BRN: 1710584
Stability: Stable. Combustible. Incompatible with strong oxidizing agents. May be water sensitive
Product Categories: Organics; Functional Materials; Phosphates (Plasticizer); Plasticizer; Organic Building Blocks; Organic Phosphates/Phosphites; Phosphorus Compounds; Alphabetic; TP - TZ;T-Z, Puriss p.a.; Analytical Reagents for General Use; Puriss p.a.; Analytical/Chromatography; Ion Sensor Materials; Plasticizer for ISE

3. Structure Descriptors of Tributyl phosphate
InChI
InChI=1/C12H27O4P/c1-4-7-10-14-17(13,15-11-8-5-2)16-12-9-6-3/h4-12H2,1-3H3
Smiles
P(OCCCC)(OCCCC)(OCCCC)=O

4. Toxicity of Tributyl phosphate

1.	skn-rbt 10 mg/24H	JIHTAB Journal of Industrial Hygiene and Toxicology. 26 (1944),269.
2.	eye-rbt 97 mg	AJOPAA American Journal of Ophthalmology. 29 (1946),1363.
3.	orl-rat LD50:1390 mg/kg	JTSCDR Journal of Toxicological Sciences. 5 (1980),270.
4.	ipr-rat LD50:251 mg/kg	GTPZAB Gigiena Truda i Professionalnye Zabolevaniia. Labor Hygiene and Occupational Diseases. 15 (8)(1971),30.
5.	ivn-rat LDLo:100 mg/kg	NATUAS Nature. 179 (1957),154.
6.	orl-mus LD50:1189 mg/kg	GTPZAB Gigiena Truda i Professionalnye Zabolevaniia. Labor Hygiene and Occupational Diseases. 15 (8)(1971),30.
7.	ihl-mus LC50:1300 mg/m³	GTPZAB Gigiena Truda i Professionalnye Zabolevaniia. Labor Hygiene and Occupational Diseases. 15 (8)(1971),30.
8.	ipr-mus LD50:159 mg/kg	GTPZAB Gigiena Truda i Professionalnye Zabolevaniia. Labor Hygiene and Occupational Diseases. 15 (8)(1971),30.
9.	scu-mus LDLo:3 g/kg	EDWU** Beitrag zur Toxikologie Technischer Weichmachungsmittel, Heinrich Eller Dissertation .(Pharmakologischen Institut der Universitat Wurzburg,Germany.: 1937).
10.

5. Safety Information of Tributyl phosphate
Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion, inhalation, and subcutaneous routes. Experimental reproductive effects. A skin, eye, and mucous membrane irritant. Combustible when exposed to heat or flame. To fight fire, use CO₂, dry chemical, fog, mist. When heated to decomposition it emits toxic fumes of POx.
Hazard Codes:

Xn,

F
Risk Statements: 22-38-40-62-48/22-36/37/38-11
R22:Harmful if swallowed.
R38:Irritating to skin.
R40:Limited evidence of a carcinogenic effect.
R62:Risk of impaired fertility.
R48/22:Harmful: danger of serious damage to health by prolonged exposure if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
R11:Highly flammable.
Safety Statements: 36/37-46-45-36/37/39-16-53
S36/37:Wear suitable protective clothing and gloves.
S46:If swallowed, seek medical advice immediately and show this container or label.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S16:Keep away from sources of ignition.
S53:Avoid exposure - obtain special instructions before use.
RIDADR: UN 1208 3/PG 2
WGK Germany: 2
RTECS: TC7700000
HS Code: 29190010

6. Preparation of Tributyl phosphate
Tributyl phosphate is manufactured by esterification of orthophosphoric acid with butyl alcohol. A laboratory synthesis proceeds with phosphorus oxychloride:
POCl₃ + 3C₄H₉OH → PO(OC₄H₉)₃ + 3HCl

Product Name

Tributyl phosphate

Synthetic route

Tributyl phosphate Consensus Reports

Tributyl phosphate Standards and Recommendations

Tributyl phosphate Analytical Methods

Tributyl phosphate Specification

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