Tributyl phosphite supplier

Name
TRIBUTYL PHOSPHITE
EINECS 203-061-3
CAS No. 102-85-2
Article Data45
CAS DataBase
Density g/cm³
Solubility Not miscible or difficult to mix in water.
Melting Point -80 °C
Formula C12H27 O3 P
Boiling Point 125 °C
Molecular Weight 250.318
Flash Point 121.1°C
Transport Information
Appearance Clear colorless liquid
Safety Moderately toxic by ingestion and skin contact. A skin and eye irritant. Has been known to damage eyes. Combustible when exposed to heat or flame. To fight fire, use CO₂, dry chemical. When heated to decomposition it emits toxic fumes of PO_x.
Risk Codes 21-34
Molecular Structure
Hazard Symbols
Synonyms 1-Butanol,1,1',1''-phosphinidynetri- (6CI); Butyl phosphite, (BuO)3P (4CI); JP 304; NSC2675; Phosphorus tributoxide (P(OBu)3); Tri-n-butyl phosphite;Tributoxyphosphine; Tributyl phosphite
PSA 41.28000
LogP 4.66340

Synthetic route

: O,O-dibutyl (tributoxymethyl)phosphonate

A: 102-85-2
tri-n-butyl phosphite

B: 542-52-9
Dibutyl carbonate

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate under 8 Torr; Heating;	A 71% B n/a

: O,O-dibutyl (tributoxymethyl)phosphonate

: 102-85-2
tri-n-butyl phosphite

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate under 8 Torr; Heating;	71%

: 71-36-3
butan-1-ol

: 102-85-2
tri-n-butyl phosphite

Conditions

Conditions	Yield
With potassium phosphate; tetrahexylammonium chloride; phosphorus trichloride In dichloromethane at 20℃; for 3h;	69%
With sodium hexachloroplatinate; phosphan at 24.9℃; Rate constant; Kinetics; also in the presence of LiCl, HCl, H2O, LiBr, NaI; var. conc. of reactants;
With ammonia; Petroleum ether; phosphorus trichloride

: 51104-80-4
diethyl ester of 2-phenylethynylphosphonous acid

: 71-36-3
butan-1-ol

A: 102-85-2
tri-n-butyl phosphite

B: 536-74-3
phenylacetylene

Conditions

Conditions	Yield
With C4H9ONa Product distribution; Heating; oth. alcohols;	A 63% B n/a

...Expand

: 42964-63-6
S,S-diethyl-N-diethylamidodithiophosphite

: 71-36-3
butan-1-ol

A: 688-62-0
triethyl trithiophosphite

B: 102-85-2
tri-n-butyl phosphite

Conditions

Conditions	Yield
at 160℃; for 8h; Product distribution; Mechanism;	A 36% B 40%

...Expand

: 42964-63-6
S,S-diethyl-N-diethylamidodithiophosphite

: 71-36-3
butan-1-ol

A: 688-62-0
triethyl trithiophosphite

B: 102-85-2
tri-n-butyl phosphite

C: 109-89-7
diethylamine

D: 75-08-1
ethanethiol

Conditions

Conditions	Yield
at 160℃; for 8h;	A 36% B 40% C n/a D n/a

...Expand

: 110-86-1
pyridine

: 10496-13-6
butyl dichlorophosphite

: 71-36-3
butan-1-ol

: 102-85-2
tri-n-butyl phosphite

...Expand

: 101-02-0
triphenyl phosphite

: 2372-45-4
sodium butanolate

: 102-85-2
tri-n-butyl phosphite

Conditions

Conditions	Yield
With benzene

: 10496-13-6
butyl dichlorophosphite

: 2372-45-4
sodium butanolate

A: 4124-92-9
dibutyl chlorophosphite

B: 102-85-2
tri-n-butyl phosphite

...Expand

: 2372-45-4
sodium butanolate

A: 1809-19-4
dibutyl hydrogen phosphite

B: 102-85-2
tri-n-butyl phosphite

Conditions

Conditions	Yield
With diethyl ether; phosphorus trichloride

: 30653-71-5
dibutyl phosphonite

: 102-85-2
tri-n-butyl phosphite

Conditions

Conditions	Yield
boron trifluoride diethyl etherate at 100 - 160℃; decomposition;

: 109-47-7
dibutyl hydrogen phosphite

A: 102-85-2
tri-n-butyl phosphite

B: 54305-86-1
diphosphorous acid tetrabutyl ester

C: 1474-75-5
n-butyl pyrophosphate

D: 682-23-5
O,O'-dibutyl-phosphoric O,O'-dibutyl-phosphorous anhydride

Conditions

Conditions	Yield
With sodium perchlorate In acetonitrile electrochemical oxidation, 2.4 A h; Pt anode, Ni cathode; Ag/AgNO3 reference electrode; Title compound not separated from byproducts;

...Expand

: 110-86-1
pyridine

: 60-29-7
diethyl ether

: 71-36-3
butan-1-ol

: 7719-12-2, 52843-90-0
phosphorus trichloride

: 102-85-2
tri-n-butyl phosphite

Conditions

Conditions	Yield
at -10℃;

...Expand

magnesium butylate: magnesium butylate

: 102-85-2
tri-n-butyl phosphite

Conditions

Conditions	Yield
With diethyl ether; phosphorus trichloride

: 54305-86-1
diphosphorous acid tetrabutyl ester

A: 102-85-2
tri-n-butyl phosphite

B nitryl chloride: nitryl chloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 64 percent / BF3*Et2O / diethyl ether / Ambient temperature 2: 71 percent / fluoroboron etherate / 8 Torr / Heating View Scheme

: 109-47-7
dibutyl hydrogen phosphite

A: 102-85-2
tri-n-butyl phosphite

B nitryl chloride: nitryl chloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 68 percent / sodium / diethyl ether / 0.5 h / 0 °C 2: 71 percent / fluoroboron etherate / 8 Torr / Heating View Scheme

: trans-(ruthenium(II)dimethylglyoximate)2(triphenylphosphine)(tri-n-butylphosphite)

: 603-35-0
triphenylphosphine

: trans-(ruthenium(II)dimethylglyoximate)2(triphenylphosphine)2

B: 102-85-2
tri-n-butyl phosphite

Conditions

Conditions	Yield
In toluene Kinetics; Soln. is prepared by injecting the ligand into serum-capped cell (under N2) containing the thermostated soln. of the complex.; UV-spectroscopy.;

...Expand

: 1809-19-4
dibutyl hydrogen phosphite

: 102-85-2
tri-n-butyl phosphite

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium 2: boron trifluoride diethyl etherate / 8 Torr / Heating View Scheme

: 54305-86-1
diphosphorous acid tetrabutyl ester

: 102-85-2
tri-n-butyl phosphite

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: boron trifluoride diethyl etherate / diethyl ether / 20 °C 2: boron trifluoride diethyl etherate / 8 Torr / Heating View Scheme

: 110-52-1
1,4-dibromo-butane

: 102-85-2
tri-n-butyl phosphite

: dibutyl(4-bromobutyl)phosphonate

Conditions

Conditions	Yield
at 118℃; for 6h;	100%

: 102-85-2
tri-n-butyl phosphite

: 21988-87-4
1,3,5-tris(bromomethyl)-2,4,6-trimethylbenzene

: 612040-41-2
C36H69O9P3

Conditions

Conditions	Yield
at 130℃; for 16.5h;	100%

: tricarbonyl(η-tropylium)chromium tetrafluoroborate

: 102-85-2
tri-n-butyl phosphite

: 61824-16-6
tricarbonyl[1-6-η-7-tri(nbutoxy)phosphoniocyclohepta-1,3,5-triene] chromium tetrafluoroborate

Conditions

Conditions	Yield
In dichloromethane org. compd. addn. dropwise to Cr-compd. suspn., pptn. on slow diethyl ether addn.; ppt. filtration off, washing (diethyl ether); elem. anal.;	100%
In acetone Kinetics; excess org. compd. addn. to Cr-compd. soln. at const. temp. (1, 5, 10, 15 and 20.5°C); stopped-flow UV spectroscopic monitoring;

: 102-85-2
tri-n-butyl phosphite

: 38521-51-6
2,3,4,5,6-pentabromobenzyl bromide

: 95452-28-1
dibutyl pentabromobenzylphosphonate

Conditions

Conditions	Yield
at 25 - 156℃; Inert atmosphere;	100%

: 542-69-8
1-iodo-butane

: 102-85-2
tri-n-butyl phosphite

: 78-46-6
dibutyl butylphosphonate

Conditions

Conditions	Yield
at 160℃; for 1.5h; Michaelis-Arbuzov Synthesis;	99%
at 150 - 160℃;

: 102-85-2
tri-n-butyl phosphite

: 104-15-4
toluene-4-sulfonic acid

: 1809-19-4
dibutyl hydrogen phosphite

Conditions

Conditions	Yield
In 1,2-dichloro-ethane for 24h; Ambient temperature; molar ratio 1:1;	98%

: C21H21F3INO

: 102-85-2
tri-n-butyl phosphite

: 9-[5-(dibutoxyphosphinyl)pentyl]-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxamide

Conditions

Conditions	Yield
at 120℃; for 18h; Neat (no solvent);	98%

: C22H23F3INO

: 102-85-2
tri-n-butyl phosphite

: [6-[9-[((2,2,2-trifluoroethyl)amino)carbonyl]-9H-fluoren-9-yl]hexyl]phosphonic acid, dibutyl ester

Conditions

Conditions	Yield
at 120℃; for 18h; Neat (no solvent);	98%

: 102-85-2
tri-n-butyl phosphite

: 18992-03-5
octadecyl bromoacetate

: 951643-33-7
octadecyl diethylphosphonoacetate

Conditions

Conditions	Yield
at 100 - 150℃; Inert atmosphere;	98%

: 102-85-2
tri-n-butyl phosphite

: 544-25-2
Cyclohepta-1,3,5-triene

: dibutyl cyclohepta-2,4,6-trien-1-ylphosphonate

Conditions

Conditions	Yield
Stage #1: Cyclohepta-1,3,5-triene With 2,3-dicyano-5,6-dichloro-p-benzoquinone In 1,2-dichloro-ethane at 20℃; for 0.0833333h; Michaelis-Arbuzov Synthesis; Inert atmosphere; Stage #2: tri-n-butyl phosphite	98%

: 102-85-2
tri-n-butyl phosphite

: 91-13-4
α,α'-dibromo-o-xylene

: tetrabutyl (1,2-phenylenebis(methylene))bis(phosphonate)

Conditions

Conditions	Yield
at 120℃; for 16h;	97%
at 120℃; for 16h;	97%

: 102-85-2
tri-n-butyl phosphite

: 40244-90-4
Chlorodiisopropylphosphane

: 42003-70-3
1,1-dibutoxy-2,2-diisopropyldiphosphine 1-oxide

Conditions

Conditions	Yield
With nickel dichloride at 150℃; for 0.5h;	96%

: 102-85-2
tri-n-butyl phosphite

: 9-[5-(dibutoxyphosphinyl)pentyl]-N-propyl-9H-fluorene-9-carboxamide

Conditions

Conditions	Yield
at 120℃; for 18h;	96%

: 102-85-2
tri-n-butyl phosphite

: 18226-42-1
1,3,5-Tris(bromomethyl)benzene

: 876908-95-1
C33H63O9P3

Conditions

Conditions	Yield
at 130℃; for 16.5h;	96%

: 102-85-2
tri-n-butyl phosphite

: 13992-25-1
1-azido-1-deoxy-β-D-glucopyranoside tetraacetate

: 1240498-34-3
2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl dibutyl phosphoramidate

Conditions

Conditions	Yield
In dichloromethane at 20℃; Staudinger reaction; stereoselective reaction;	96%
In tetrahydrofuran at 25℃; for 24h; Staudinger Azide Reduction; chemoselective reaction;	90%

: 102-85-2
tri-n-butyl phosphite

: 37942-07-7
3,5-di-tert-butyl-2-hydroxybenzaldehyde

: 109-77-3
malononitrile

: dibutyl (2-amino-6,8-di-tert-butyl-3-cyano-4H-chromen-4-yl)phosphonate

Conditions

Conditions	Yield
With silver In ethanol for 0.5h; Reflux;	96%

...Expand

: 512-56-1
trimethyl phosphite

: 77-99-6
1,1,1-tri(hydroxymethyl)propane

: 102-85-2
tri-n-butyl phosphite

: 126-58-9
Dipentaerythritol

: C13H25O10P3

Conditions

Conditions	Yield
Stage #1: 1,1,1-tri(hydroxymethyl)propane; tri-n-butyl phosphite; Dipentaerythritol With sulfuric acid at 85℃; for 5h; Inert atmosphere; Stage #2: trimethyl phosphite With 1-Bromopentane at 185℃; for 16h;	95.6%

...Expand

: 102-85-2
tri-n-butyl phosphite

: 66517-44-0
tert-butyldiiodophosphane

: C20H45O6P3

Conditions

Conditions	Yield
In dichloromethane at -40℃;	95%

: 102-85-2
tri-n-butyl phosphite

: 78-46-6
dibutyl butylphosphonate

Conditions

Conditions	Yield
With iodine for 24h; Heating;	95%
With trifluorormethanesulfonic acid at 60℃; for 16h; Schlenk technique; Inert atmosphere;	85%
With trifluorormethanesulfonic acid at 60℃; for 16h; Inert atmosphere;

: 102-85-2
tri-n-butyl phosphite

: 684-16-2
Hexafluoroacetone

: 87779-54-2
2,2,2-Tributoxy-4,4,5,5-tetrakis-trifluoromethyl-2λ5-[1,3,2]dioxaphospholane

Conditions

Conditions	Yield
at 25℃; for 96h; sealed tube;	95%

: 102-85-2
tri-n-butyl phosphite

: 300344-95-0
E-3-bromo-1-propenyl t-butyl sulfone

: 300344-96-1
[(E)-3-(2-Methyl-propane-2-sulfonyl)-allyl]-phosphonic acid dibutyl ester

Conditions

Conditions	Yield
at 130℃; for 12h; Arbusov substitution;	95%

: 12266-72-7
(1,5-cylooctadiene)di-iodoplatinum(II)

: 102-85-2
tri-n-butyl phosphite

: 97277-53-7
cis-diiodobis(tri-n-butyl phosphite)platinum(II)

Conditions

Conditions	Yield
In hexane (white spot N2); to the starting complex in hexane addn. of the phosphite (2,5 h); oil is dried under vac., chromy., elem. anal.;	95%

: 102-85-2
tri-n-butyl phosphite

: C110H55ClO10

: C114H64O10

Conditions

Conditions	Yield
In toluene at 100 - 105℃; Arbuzov Reaction; Inert atmosphere;	95%

: 102-85-2
tri-n-butyl phosphite

: 3206-35-7
(4-chloro-benzylidene)-hydrazinecarboxylic acid ethyl ester

: 762-42-5
dimethyl acetylenedicarboxylate

: dimethyl 2-(dibutoxyphosphoryl)-3-[2-(4-chlorobenzylidene)-1-(ethoxycarbonyl)hydrazino]succinate

Conditions

Conditions	Yield
In acetonitrile at 20℃; for 24h;	94%

...Expand

: 102-85-2
tri-n-butyl phosphite

: 4083-64-1
Tosyl isocyanate

: 62-53-3
aniline

: 1256338-86-9
C18H22N2O3S

Conditions

Conditions	Yield
Stage #1: Tosyl isocyanate; aniline In dichloromethane at 25℃; for 0.0833333h; Stage #2: tri-n-butyl phosphite With dimethyl acetylenedicarboxylate In dichloromethane at 25℃; for 2h;	94%

...Expand

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: 102-85-2
tri-n-butyl phosphite

: 109-77-3
malononitrile

: dibutyl (2-amino-3-cyano-6-methoxy-4H-chromen-4-yl)phosphonate

Conditions

Conditions	Yield
With silver In ethanol for 0.25h; Reflux;	94%

...Expand

: 102-85-2
tri-n-butyl phosphite

: 80-97-7
Cholestanol

: Phosphoric acid dibutyl ester (3S,5S,8R,9S,10S,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Conditions

Conditions	Yield
With lutidine; tellurium tetrachloride In dichloromethane for 1h; Ambient temperature;	93%

: 102-85-2
tri-n-butyl phosphite

: 112-55-0
1-dodecylthiol

: Thiophosphoric acid O,O'-dibutyl ester S-dodecyl ester

Conditions

Conditions	Yield
With 2,6-dimethylpyridine; tellurium tetrachloride In dichloromethane for 1h; -42 deg C, 5-10 min; room temp. 1 h;	93%

: 102-85-2
tri-n-butyl phosphite

: 37746-78-4
4-bromo-trans-crotonic acid ethyl ester

: (E)-4-(Dibutoxy-phosphoryl)-but-2-enoic acid ethyl ester

Conditions

Conditions	Yield
at 85 - 90℃; for 12h;	93%

: 102-85-2
tri-n-butyl phosphite

: 95-53-4
o-toluidine

: 108-46-3
recorcinol

: 6264-98-8
3-(o-tolylamino)phenol

Conditions

Conditions	Yield
In water	93%

...Expand

Tributyl phosphite Chemical Properties

IUPAC Name:Tributyl phosphite (102-85-2)
Synonyms: 1,1,1-Phosphinidynetri-1-butano ; Butyl phosphite ((C₄H₉O)₃P) ; jp304 ; Phosphorus derivative ; Phosphorustributoxide(p(obu)3) ; Syn-O-Ad P-312 ; Tributoxyphosphine ; Tributylfosfit
Product Categories: Organic Building Blocks;Organic Phosphates/Phosphites;Phosphorus Compounds
CAS: 102-85-2
Molecular Formula :C₁₂H₂₇O₃P
Molecular Weight: 250.31
Molecular Structure:
EINECS: 203-061-3
Mol File: 102-85-2.mol
Flash Point: 121.1 °C
Enthalpy of Vaporization: 48.57 kJ/mol
Melting point: -80 °C
Boiling Point: 268.1 °C at 760 mmHg
Vapour Pressure: 0.013 mmHg at 25°C
Density : 0.925 g/mL at 25 °C(lit.)
Refractive index: n20/D 1.431(lit.)
BRN: 1703866
Appearance: Clear colorless liquid

Tributyl phosphite Uses

Tributyl phosphite (102-85-2) is used as lubricants, preservatives, heat stabilizers of Intensifier.

Tributyl phosphite Toxicity Data With Reference

1.	skn-rbt 10 mg/24H	JIHTAB Journal of Industrial Hygiene and Toxicology. 26 (1944),269.
2.	eye-rbt 500 mg	AJOPAA American Journal of Ophthalmology. 29 (1946),1363.
3.	orl-rat LD50:3000 mg/kg	JIHTAB Journal of Industrial Hygiene and Toxicology. 26 (1944),269.
4.	skn-rbt LD50:2 g/kg	AIHAAP American Industrial Hygiene Association Journal. 34 (1973),286.

Tributyl phosphite Consensus Reports

Reported in EPA TSCA Inventory.

Tributyl phosphite Safety Profile

Hazard Codes C
Risk Statements 21-34
21:Tributyl phosphite (102-85-2) is harmful in contact with skin.
34: Tributyl phosphite (102-85-2) can causes burns.
Safety Statements 26-36/37/39-45
25: Avoid contact with eyes
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
RIDADR UN 3265 8/PG 3
WGK Germany 3
RTECS TH0875000

Tributyl phosphite Specification

1.General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
2.Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam
3.Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
4.Storage: Store Tributyl phosphite (102-85-2) in a cool, dry place. Store in a tightly closed container.

Product Name

TRIBUTYL PHOSPHITE

Synthetic route

Tributyl phosphite Chemical Properties

Tributyl phosphite Uses

Tributyl phosphite Toxicity Data With Reference

Tributyl phosphite Consensus Reports

Tributyl phosphite Safety Profile

Tributyl phosphite Specification

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