Conditions | Yield |
---|---|
100% |
Conditions | Yield |
---|---|
With 1-methyl-1H-imidazole; diethyl chlorophosphate | 94% |
With pyridine hydrochloride; trifluoroacetic acid |
chloro-trimethyl-silane
C6H9F3O4S
A
trifluoracetyl chloride
B
Trimethylsilyl-1-butansulfonat
Conditions | Yield |
---|---|
for 24h; Ambient temperature; | A n/a B 91% |
1-Chlor-1,2,2,2-tetrafluorethansulfenylchlorid
A
trifluoracetyl chloride
B
trifluorothioacetyl fluoride
Conditions | Yield |
---|---|
With Cu-cuttings In gas at 400℃; under 0.008 Torr; | A 1% B 89% |
trifluorormethanesulfonic acid
hexaiodobenzene
A
trifluoracetyl chloride
B
C6I6(2+)*2CF3O3S(1-)
C
C6ClI5(1+)*2CF3O3S(1-)
Conditions | Yield |
---|---|
With chlorine; trifluoroacetyl triflate at 25℃; for 4h; Product distribution; Mechanism; various oxidating agent; | A n/a B 88% C 7% |
With chlorine; trifluoroacetyl triflate at 25℃; for 4h; | A n/a B 88% C 7% |
With chlorin; trifluoroacetyl triflate at 25℃; for 4h; | A n/a B 88% C 7% |
methanesulphonyltrifluoroacetic anhydride
acetyl chloride
A
trifluoracetyl chloride
B
Acetyl methanesulfonate
Conditions | Yield |
---|---|
at 50℃; for 1h; Yield given; | A n/a B 86.5% |
at 50℃; for 1h; Yields of byproduct given; | A n/a B 86.5% |
Conditions | Yield |
---|---|
With phosphorus pentachloride In 1,2-dichloro-ethane for 3h; | 81% |
With benzoyl chloride at 200℃; for 3.5h; | 50% |
With phosphorus pentachloride |
trifluorothioacetic acid
A
trifluoracetyl chloride
B
N-Chlorosulfuryltrifluoroacetimide
Conditions | Yield |
---|---|
With isocyanate de chlorosulfonyle Ambient temperature; | A n/a B 66% |
1,2-bis(trifluoroacetyl)hydrazine
A
trifluoracetyl chloride
B
2,5-dichloro-1,1,1,6,6,6-hexafluoro-3,4-diaza-hexa-2,4-diene
Conditions | Yield |
---|---|
With N,N-dimethylaniline hydrochloride; trichlorophosphate Heating; Yield given; | A n/a B 48% |
With N,N-dimethylaniline hydrochloride; trichlorophosphate Heating; Yields of byproduct given; | A n/a B 48% |
1,1,1-trifluoro-2,2-dichloroethane
A
trifluoracetyl chloride
B
trifluoroacetic acid
Conditions | Yield |
---|---|
With oxygen; chlorine Irradiation.UV-Licht; |
Conditions | Yield |
---|---|
With zinc(II) chloride |
Conditions | Yield |
---|---|
With sulfur trioxide |
Conditions | Yield |
---|---|
With p-toluenesulfonyl chloride |
diethyl chlorophosphate
trifluoroacetic anhydride
A
trifluoracetyl chloride
B
O,O-Diethyl O-Trifluoroacetyl Phosphate
Conditions | Yield |
---|---|
With 1-methyl-1H-imidazole Ambient temperature; |
trifluoroacetic anhydride
A
trifluoracetyl chloride
B
O,O-Diethyl O-Trifluoroacetyl Phosphate
Conditions | Yield |
---|---|
With 1-methyl-1H-imidazole; diethyl chlorophosphate Ambient temperature; Yield given; |
1,1,1-trifluoro-2-chloroethylperoxyl radical
A
trifluoracetyl chloride
C
C2HClF3O
Conditions | Yield |
---|---|
at 22.9℃; Rate constant; self-reaction; |
C2HClF3O
trifluoracetyl chloride
Conditions | Yield |
---|---|
With oxygen at 22.9℃; under 700 Torr; Product distribution; |
Conditions | Yield |
---|---|
With oxygen; chlorine Oxidation; Photolysis; | 102 % |
Stage #1: 1,1,1-trifluoro-2,2-dichloroethane With oxygen at 20 - 40℃; under 1000 - 2000 Torr; Stage #2: for 8h; Conversion of starting material; UV-irradiation; | |
With ozone; copper(II) sulfate at 30℃; for 730.5h; Reagent/catalyst; Temperature; Irradiation; | |
With oxygen at 5℃; for 1h; Concentration; Temperature; Irradiation; |
trifluoracetyl chloride
Conditions | Yield |
---|---|
With phosphorus trichloride |
trifluoracetyl chloride
Conditions | Yield |
---|---|
With trichlorophosphate |
2,2,2-Trifluoroacetaldehyde
chlorine
A
trifluoracetyl chloride
B
trifluoromethan
C
chlorotrifluoromethane
Conditions | Yield |
---|---|
im UV-Licht; |
1,1,1-Trichloro-2,2,2-trifluoroethane
A
trifluoracetyl chloride
B
methylammonium carbonate
Conditions | Yield |
---|---|
UV-Licht.Irradiation; |
1,1,1-trifluoro-2,2-dichloroethane
A
hydrogenchloride
B
trifluoracetyl chloride
C
methylammonium carbonate
D
trifluoroacetic acid
Conditions | Yield |
---|---|
im UV-Licht; |
1,1,1-trifluoro-2,2-dichloroethane
chlorine
A
hydrogenchloride
B
trifluoracetyl chloride
C
methylammonium carbonate
D
trifluoroacetic acid
Conditions | Yield |
---|---|
im UV-Licht; |
3-chlorotrifluoro-1,2-oxathietane 2,2-dioxide
4-chlorotrifluoro-1,2-oxathietane 2,2-dioxide
A
chlorotrifluoroethylene oxide
B
trifluoracetyl chloride
C
chlorodifluoroacetyl fluoride
Conditions | Yield |
---|---|
byproducts: SO2; at 245-255°C; detected by IR- and mass spectroscopy; | |
byproducts: SO2; at 245-255°C; |
trans-1-chloro-3,3,3-trifluoropropene
A
trifluoracetyl chloride
B
formyl chloride
C
2,2,2-Trifluoroacetaldehyde
D
3,3,3-trifluoro-2-chloropropionaldehyde
E
3,3,3-trifluoro-2-chloropropionyl chloride
Conditions | Yield |
---|---|
With nitrogen; oxygen; chlorine at 21.84℃; under 700 Torr; UV-irradiation; |
trans-1-chloro-3,3,3-trifluoropropene
A
trifluoracetyl chloride
B
formyl chloride
C
2,2,2-Trifluoroacetaldehyde
D
3,3,3-trifluoro-2-chloropropionaldehyde
E
3,3,3-trifluoro-2-chloropropionyl chloride
F
3,3-dichloro-1,1,1-trifluoroacetone
Conditions | Yield |
---|---|
With nitrogen; oxygen; chlorine at 21.84℃; under 700 Torr; UV-irradiation; |
trans-1-chloro-3,3,3-trifluoropropene
A
trifluoracetyl chloride
B
formyl chloride
C
3,3,3-trifluoro-2-chloropropionaldehyde
D
3,3,3-trifluoro-2-chloropropionyl chloride
E
3,3-dichloro-1,1,1-trifluoroacetone
Conditions | Yield |
---|---|
With nitrogen; oxygen; chlorine at 21.84℃; under 700 Torr; UV-irradiation; |
trifluoracetyl chloride
2-Amino-3-trifluoromethylsulfanyl-benzoic acid
2-Trifluoromethyl-8-trifluoromethylsulfanyl-benzo[d][1,3]oxazin-4-one
Conditions | Yield |
---|---|
With 4-methyl-morpholine In dichloromethane for 20h; Ambient temperature; | 100% |
trifluoracetyl chloride
di-H-trifluoroethane-2-sulfonyl fluoride
triethylamine
Conditions | Yield |
---|---|
In diethyl ether at -70 - 20℃; | 100% |
trifluoracetyl chloride
ethyl vinyl ether
4-chloro-4-ethoxy-1,1,1-trifluoro-3-butan-2-one
Conditions | Yield |
---|---|
at -30℃; Product distribution / selectivity; | 100% |
at 0 - 25℃; for 3.95h; Product distribution / selectivity; | 93% |
at 0 - 25℃; for 3.95h; Product distribution / selectivity; | 93% |
trifluoracetyl chloride
ethyl vinyl ether
A
4-ethoxy-1,1,1-trifluoro-3-butene-2-one
B
4-chloro-4-ethoxy-1,1,1-trifluoro-3-butan-2-one
Conditions | Yield |
---|---|
With sodium hydroxide at -10 - 80℃; under 262.526 - 760.051 Torr; Product distribution / selectivity; | A 85% B 100% |
Conditions | Yield |
---|---|
In dichloromethane at 0℃; for 2h; Inert atmosphere; | 100% |
trifluoracetyl chloride
3-methyl-5-aminopyrazole
3-trifluoroacetylamino-5-methylpyrazole
Conditions | Yield |
---|---|
With triethylamine In 1,4-dioxane at 10 - 20℃; | 99% |
trifluoracetyl chloride
3-dimethylaminoacrylonitrile
2-((dimethylamino)methylene)-4,4,4-trifluoro-3-oxobutyronitrile
Conditions | Yield |
---|---|
With pyridine In toluene Product distribution / selectivity; Cooling with ice; Inert atmosphere; | 99% |
trifluoracetyl chloride
2-(2,4-dimethylphenylsulphanyl)benzeneamine
Conditions | Yield |
---|---|
With sodium hydroxide In acetonitrile | 98% |
Conditions | Yield |
---|---|
at 35 - 58℃; for 1h; Temperature; | 97.86% |
With hydrogenchloride In water; ethyl acetate at 40 - 60℃; for 0.333333h; Temperature; |
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide for 4h; Heating; | 97% |
trifluoracetyl chloride
N-(2-(2-bromopyridin-3-yl)ethyl)-2,2,2-trifluoroacetamide
Conditions | Yield |
---|---|
With pyridine In dichloromethane at 0 - 20℃; Inert atmosphere; | 97% |
Conditions | Yield |
---|---|
20°C, 12 h, shaking in autoclave; | 96.5% |
20°C, 12 h, shaking in autoclave; | 96.5% |
trifluoracetyl chloride
1,1,1-trifluoro-3-(triphenylphosphoranylidene)-2-propanone
Conditions | Yield |
---|---|
In toluene 1.) 110 deg C, 4 h, 2.) r.t., 1 h; | 96% |
trifluoracetyl chloride
Conditions | Yield |
---|---|
In acetonitrile at 55℃; for 0.416667h; Microwave irradiation; | 96% |
trifluoracetyl chloride
2-ethoxyprop-1-ene
1,1,1-trifluoro-4-ethoxypent-3-en-2-one
Conditions | Yield |
---|---|
With diethylamine In cyclohexane at 5 - 10℃; for 3h; Reagent/catalyst; Solvent; Temperature; Large scale; | 96% |
trifluoracetyl chloride
9,10,11-Trimethoxy-3-methylsulfanyl-6,7-dihydro-5H-dibenzo[a,c]cyclohepten-5-ol
Conditions | Yield |
---|---|
In pyridine | 95.2% |
trifluoracetyl chloride
2-Oxa-3-azabicyclo<2.2.2>oct-5-ene hydrochloride
Conditions | Yield |
---|---|
With triethylamine In dichloromethane for 12h; | 95% |
trifluoracetyl chloride
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride
N-trifluoroacetyl-L-phenylalanine
Conditions | Yield |
---|---|
In trifluoroacetic acid | 95% |
Conditions | Yield |
---|---|
at -30℃; | 95% |
trifluoracetyl chloride
dimethyl (2,2,2-trichloro-1-hydroxyethyl)phosphonothioate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at -20 - 20℃; | 94.7% |
trifluoracetyl chloride
2-phenyl-5-methoxyltryptamine
Conditions | Yield |
---|---|
With triethylamine In dichloromethane for 3h; Ambient temperature; | 94% |
With triethylamine In dichloromethane |
Conditions | Yield |
---|---|
With triethylamine In dichloromethane for 3h; Ambient temperature; | 94% |
With triethylamine In dichloromethane |
trifluoracetyl chloride
methyl 2-(4-{[4-(trifluoromethyl)-1,3-thiazol-2-yl]amino}phenyl)propanoate
methyl 2-(4-{(trifluoroacetyl)[4-(trifluoromethyl)-1,3-thiazol-2-yl]amino}phenyl)propanoate
Conditions | Yield |
---|---|
With potassium carbonate In tetrahydrofuran for 4h; Reflux; | 94% |
trifluoracetyl chloride
para-methylacetophenone
4,4,4-trifluoro-1-(4-methylphenyl)butane-1,3-dione
Conditions | Yield |
---|---|
Stage #1: para-methylacetophenone With sodium methylate In di-isopropyl ether at 50℃; for 6h; Stage #2: trifluoracetyl chloride In toluene at 40℃; for 2h; Reagent/catalyst; Concentration; Temperature; Solvent; | 93% |
trifluoracetyl chloride
ethyl vinyl ether
4-ethoxy-1,1,1-trifluoro-3-butene-2-one
Conditions | Yield |
---|---|
With pyridine In toluene at 0 - 5℃; for 4h; Temperature; Sealed tube; | 92.3% |
at 0 - 80℃; Product distribution / selectivity; thermolysis; | 90.4% |
at 10 - 80℃; for 8h; Product distribution / selectivity; Inert atmosphere; Industry scale; | 87% |
With 2,6-di-tert-butyl-4-methyl-phenol at 0 - 80℃; Product distribution / selectivity; thermolysis; | 83% |
trifluoracetyl chloride
4-benzylpyperidine
1-(trifluoroacetyl)-4-benzylpiperidine
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 1h; Acylation; | 92% |
trifluoracetyl chloride
2,2-dimethyl-1,3-dioxolane-4-methanamine
Conditions | Yield |
---|---|
With triethylamine In dichloromethane Cooling with ice; | 92% |
IUPAC Name: 2,2,2-Trifluoroacetyl chloride (354-32-5)
Synonyms: Trifluoroacetyl chloride ; Acetyl chloride, trifluoro- ; Perfluoroacetylchloride ; Trifluoro-acetylchlorid ;Trifluoroacetyl chloride cyl. with 800 ; Trifluoroacetylchloride97% ; Trifluoracetylchlorid ; Trifluoroacetic acid chloride
CAS: 354-32-5
Molecular Formula: C2ClF3O
Molecular Weight:132.47
Molecular Structure:
EINECS: 206-556-2
Product Categories: Chemical Synthesis;Compressed and Liquefied Gases;Synthetic Reagents
Mol File: 354-32-5.mol
Surface Tension: 18.3 dyne/cm
Density: 1.532 g/cm3
Melting point: -146 °C(lit.)
Enthalpy of Vaporization: 23.25 kJ/mol
Boiling Point: -27 °C(lit.)
Vapour Pressure: 3760 mmHg at 25°C
Vapor density: 4.6 (vs air)
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
guinea pig | LC | inhalation | > 35300ppb/6H (35.3ppm) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | National Technical Information Service. Vol. OTS0536764, |
mouse | LCLo | inhalation | 35300ppb/6H (35.3ppm) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | National Technical Information Service. Vol. OTS0536764, |
rat | LCLo | inhalation | 35300ppb/6H (35.3ppm) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | National Technical Information Service. Vol. OTS0536764, |
Reported in EPA TSCA Inventory.
Hazard Codes C
Risk Statements 14-35-37
14: Trifluoroacetyl chloride (354-32-5) reacts violently with water
35: Trifluoroacetyl chloride (354-32-5) can causes severe burns
37: Irritating to the respiratory system
Safety Statements 26-36/37/39-45
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
36/37/39: Trifluoroacetyl chloride (354-32-5) used, please wear suitable protective clothing, gloves and eye/face protection
RIDADR UN 3057 2.3
WGK Germany 2
RTECS AO7150000
F 4.5-19-21
Hazard Note Corrosive
HazardClass 2.3 .
DOT Classification: 2.2; Label: Nonflammable Gas, Corrosive
1.General Description: A colorless gas. Shipped as a liquid under own vapor pressure. Contact with the unconfined liquid may frostbite unprotected skin. Very toxic by inhalation and may severely irritate skin, eyes, and mucous membranes. Under prolonged exposure to fire or heat the containers may rupture violently and rocket.
2.Air & Water Reactions: Reacts avidly with water and with moisture in the air to give fumes of hydrogen chloride, a water-soluble toxic gas.
3.Reactivity Profile: Trifluoroacetyl chloride is incompatible with strong oxidizing agents, alcohols, amines, alkalis. Reacts vigorously with amines and alkalis. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
4.Health Hazard: Toxic; may be fatal if inhaled, ingested or absorbed through skin. Vapors are extremely irritating and corrosive. Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control may cause pollution.
5.Fire Hazard: Some may burn but none ignite readily. Vapors from liquefied gas are initially heavier than air and spread along ground. Some of these materials may react violently with water. Cylinders exposed to fire may vent and release toxic and/or corrosive gas through pressure relief devices. Containers may explode when heated. Ruptured cylinders may rocket.
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