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Hangzhou Huarong Pharm Co., Ltd.

KDMF USDMF EDMF are all available! Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for t

Irinotecan Hcl KDMF USDMF EDMF

Cas:100286-90-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

high purity Irinotecan hydrochloride cas no.100286-90-6

Cas:100286-90-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Irinotecan hydrochloride Manufacturer/High quality/Best price/In stock

Cas:100286-90-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Kono Chem Co.,Ltd

QuickDetails CASNo.: 136572-09-3 OtherNames: … Appearance:White fine powder Storage:Preserve in tightly sealed,light and oxygen resistant containers Package:Drum and foil bag,or required by clients Application:For supplements and pharmaceut

Irinotecan hydrochloride

Cas:100286-90-6

Min.Order:1 Kilogram

FOB Price: $150.0

Type:Other

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Irinotecan hydrochloride injection 40mg/2ml;100mg/5ml

Cas:100286-90-6

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Irinotecan hydrochloride Cas 100286-90-6 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Yellowish or yellow crystalline powder Storage:Refrigerator Pac

Factory supply Irinotecan hydrochloride Cas 100286-90-6 with favorable price

Cas:100286-90-6

Min.Order:10 Gram

FOB Price: $43.0 / 45.0

Type:Trading Company

inquiry

Hefei TNJ chemical industry co.,ltd

Good products, good service. We have professional sales team working on sales service for 15 years. Good products can win good market but can not stand long without good service. We have strict sales regulation and service procedure to make sure yo

Irinotecan Hydrochloride

Cas:100286-90-6

Min.Order:1 Metric Ton

Negotiable

Type:Trading Company

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Irinotecan

Cas:100286-90-6

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Natural Extract 98% Irinotecan hydrochloride 100286-90-6 HACCP Manufacturer

Cas:100286-90-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Irinotecan hydrochloride

Cas:100286-90-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name:Irinotecan HCL CAS NO:100286-90-6 Grade:Medical scientific research and export Molecular formula:C33H39ClN4O6 Molecular weight:623.139 Product Quality 12 years of chemical raw materials Mature operation of the industry System stabilit

Irinotecan HCL/ CAS:100286-90-6/Irinotecan HCL raw material/ high-quality

Cas:100286-90-6

Min.Order:25 Kilogram

FOB Price: $2.0 / 3.0

Type:Other

inquiry

Henan Tianfu Chemical Co., Ltd.

Product Name: Irinotecan hydrochloride Synonyms: Camptothecin II;CPT-II;[1,4′-Bipiperidine]-1′-carboxylic acid, CPT-11,(S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,

100286-90-6 Irinotecan hydrochloride

Cas:100286-90-6

Min.Order:1 Gram

FOB Price: $8900.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

China Made Irinotecan HCl Powder Pharmaceutical Chemicals CAS 100286-90-6

Cas:100286-90-6

Min.Order:1 Kilogram

FOB Price: $50.0 / 80.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 100286-90-6 with competitive price

Cas:100286-90-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Irinotecan hydrochloride

Cas:100286-90-6

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Irinotecan hydrochloride/ LIDE PHARMA- Factory supply / Best price

Cas:100286-90-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

Our Adwantage: 1.We have stock so we can delivery quickly at the very day when receive the payment. 2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order. 3.High quality gua

Irinotecan hydrochloride / Irinotecan HCl CAS 100286-90-6

Cas:100286-90-6

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

99% Pharmaceutical Grade Irinotecan Hydrochloride CAS No.: 100286-90-6 with High Quality Irinotecan HCl

Cas:100286-90-6

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Irinotecan hydrochloride 100286-90-6

Cas:100286-90-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Leader Biochemical Group

About Product Details Items Specifications Test Results Appearance White to white crystalline powde

Supply High Quality Irinotecan hydrochloride CAS 100286-90-6 For research Use only

Cas:100286-90-6

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Irinotecan hydrochloride CAS:100286-90-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic

Irinotecan hydrochloride CAS:100286-90-6

Cas:100286-90-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Irinotecan hcl

Cas:100286-90-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

1)quick response within 12 hours; 2)quality guarantee: all products are strictly tested by our qc, confirmed by qa and approved by third party lab in china, usa, canada, germany, uk, italy, france etc. 3) oem/odm available; 4) reasonable &amp

high purity Irinotecan hydrochloride cas no.100286-90-6 CAS NO.100286-90-6

Cas:100286-90-6

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:100286-90-6

Cas:100286-90-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou ZeErRui Chemical Co., Ltd.

Hangzhou ZeErRui Chemical Co., Ltd. is a leading company that is focused on developing and producing high-quality flavor ingredients used for foods, pharmaceutic, cosmetics, and daily-use goods. Our goal is to produce flavor ingredients through scien

Irinotecan Hydrochloride china manufacture

Cas:100286-90-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Irinotecan hydrochloride

Cas:100286-90-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

Good Quality Irinotecan hydrochloride CAS 100286-90-6

Cas:100286-90-6

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Irinotecan hydrochloride

Cas:100286-90-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Binbo Biological Co., Ltd

1.high purity 2.consistent quality 3.competitive price 4.fast shipping Binbo Biological Products Co. Ltd., is a professional high-tech enterprise which engaged in Biological products and raw materials. Binbo is engaged in R&D with perfect eq

High Quality Irinotecan hydrochloride Powder

Cas:100286-90-6

Min.Order:1 Kilogram

FOB Price: $0.1 / 0.2

Type:Lab/Research institutions

inquiry

Synthetic route

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

Conditions
ConditionsYield
With hydrogenchloride In dichloromethane; water at 0℃; for 2 - 3h; Product distribution / selectivity;100%
With hydrogenchloride In tetrahydrofuran; water Product distribution / selectivity;100%
With hydrogenchloride In water Product distribution / selectivity;95%
4-piperidinopiperidin
4897-50-1

4-piperidinopiperidin

7-ethyl-10-hydroxycamptothecin
86639-52-3, 110714-48-2, 130144-34-2

7-ethyl-10-hydroxycamptothecin

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

Conditions
ConditionsYield
Stage #1: 4-piperidinopiperidine-1-carbonyl chloride hydrochloride; 7-ethyl-10-hydroxycamptothecin With triethylamine In pyridine; dichloromethane at 30 - 40℃; for 1.5h;
Stage #2: 4-piperidinopiperidin In pyridine; dichloromethane for 0.5h;
90%
1-chloroformyl-4-piperidinylpiperidine monohydrochloride

1-chloroformyl-4-piperidinylpiperidine monohydrochloride

7-ethyl-10-hydroxycamptothecin
86639-52-3, 110714-48-2, 130144-34-2

7-ethyl-10-hydroxycamptothecin

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

Conditions
ConditionsYield
Stage #1: 4-piperidinopiperidine-1-carbonyl chloride hydrochloride; 7-ethyl-10-hydroxycamptothecin With pyridine; triethylamine In dichloromethane at 30 - 40℃; for 1.5h;
Stage #2: With 4-piperidinopiperidin In dichloromethane at 0 - 80℃; for 0.5h; pH=4.0;
Stage #3: With hydrogenchloride In water; acetonitrile at 20℃; for 20h; Product distribution / selectivity;
90%
Stage #1: 4-piperidinopiperidine-1-carbonyl chloride hydrochloride; 7-ethyl-10-hydroxycamptothecin With pyridine; triethylamine In dichloromethane at 20℃; for 2h;
Stage #2: With hydrogenchloride In water at 0 - 80℃; for 20h; pH=4.0; Product distribution / selectivity;
80%
With triethylamine In pyridine; dichloromethane; water at 20℃; for 2h;80%
irinotecan carboxylate

irinotecan carboxylate

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

Conditions
ConditionsYield
With Britton-Robinson's buffer pH 6.0; water at 37℃; Equilibrium constant; Kinetics; Thermodynamic data; Ea, A, var. pH, var. temp., var. time;
7-ethyl-10-[4-(1-piperidino)-1-piperidino]carboxyoxycamptothecin acetic acid salt

7-ethyl-10-[4-(1-piperidino)-1-piperidino]carboxyoxycamptothecin acetic acid salt

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

Conditions
ConditionsYield
With hydrogenchloride In ethanol; n-heptane; water at 0 - 10℃; for 1h; pH=< 4;
With hydrogenchloride In ethanol; water; ethyl acetate at 0 - 10℃; for 1h; pH=< 4;
With hydrogenchloride In ethanol; water; ethyl acetate at 0 - 10℃; for 1h; pH=< 4;
With hydrogenchloride In methanol; water; ethyl acetate at 0 - 10℃; for 1h; pH=< 4;
With hydrogenchloride In methanol at 50℃;
(S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinolin-9-yl [1,4'bipiperidine]-1'-carboxylate acetate

(S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinolin-9-yl [1,4'bipiperidine]-1'-carboxylate acetate

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

Conditions
ConditionsYield
With hydrogenchloride In methanol; water at 50℃;
4-piperidinopiperidin
4897-50-1

4-piperidinopiperidin

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: dichloromethane; acetonitrile / 20 - 70 °C
1.2: 20 °C
2.1: triethylamine; pyridine; acetamide / dichloromethane / 2 h / 30 - 40 °C / Inert atmosphere
3.1: hydrogenchloride / water
View Scheme
Multi-step reaction with 3 steps
1.1: dichloromethane; hexane; acetonitrile / 20 - 25 °C
1.2: 20 °C
2.1: pyridine / dichloromethane; acetamide / 2 h / 30 - 40 °C / Inert atmosphere
3.1: hydrogenchloride / water / 20 h / 2 - 70 °C
View Scheme
Multi-step reaction with 3 steps
1: dichloromethane / 0 - 20 °C
2: 1-Methylpyrrolidine / dichloromethane / 20 - 45 °C
3: hydrogenchloride / water / 3 h / 70 °C
View Scheme
Multi-step reaction with 3 steps
1: N,N-dimethyl-formamide / 3 h / 60 - 65 °C
2: dichloromethane / 6 h / 45 - 50 °C
3: hydrogenchloride / water / 12 h / 20 °C
View Scheme
7-ethyl-10-hydroxycamptothecin
86639-52-3, 110714-48-2, 130144-34-2

7-ethyl-10-hydroxycamptothecin

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine; pyridine; acetamide / dichloromethane / 2 h / 30 - 40 °C / Inert atmosphere
2: hydrogenchloride / water
View Scheme
Multi-step reaction with 2 steps
1: pyridine / dichloromethane; acetamide / 2 h / 30 - 40 °C / Inert atmosphere
2: hydrogenchloride / water / 20 h / 2 - 70 °C
View Scheme
4-piperidinopiperidine-1-carbonyl chloride
103816-19-9

4-piperidinopiperidine-1-carbonyl chloride

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine; pyridine; acetamide / dichloromethane / 2 h / 30 - 40 °C / Inert atmosphere
2: hydrogenchloride / water
View Scheme
Multi-step reaction with 2 steps
1: pyridine / dichloromethane; acetamide / 2 h / 30 - 40 °C / Inert atmosphere
2: hydrogenchloride / water / 20 h / 2 - 70 °C
View Scheme
(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
110351-94-5

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: trifluoroacetic acid / toluene / 20 h / 85 - 90 °C / Industry scale
2: 1-Methylpyrrolidine / dichloromethane / 20 - 45 °C
3: hydrogenchloride / water / 3 h / 70 °C
View Scheme
2'-amino-5'-hydroxypropiophenone
35364-15-9

2'-amino-5'-hydroxypropiophenone

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: trifluoroacetic acid / toluene / 20 h / 85 - 90 °C / Industry scale
2: 1-Methylpyrrolidine / dichloromethane / 20 - 45 °C
3: hydrogenchloride / water / 3 h / 70 °C
View Scheme
Multi-step reaction with 3 steps
1: trifluoroacetic acid / toluene / 6 h / 80 °C
2: triethylamine; pyridine / 2 h / 20 °C / Inert atmosphere
3: hydrogenchloride; water / 3 h / 20 - 70 °C
View Scheme
Multi-step reaction with 4 steps
1.1: toluene-4-sulfonic acid / toluene / 5 h / Reflux
2.1: lithium hydroxide / methanol; water / 1 h / 25 - 30 °C
2.2: 18 - 22 °C
3.1: sulfuric acid / 2 h / 0 - 5 °C
4.1: triethylamine; pyridine / dichloromethane / 20 - 40 °C
4.2: pH 2-3
View Scheme
1-(5-fluoro-2-nitrophenyl)propan-1-one
924648-17-9

1-(5-fluoro-2-nitrophenyl)propan-1-one

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: sodium hydroxide / 2 h / 0 - 20 °C
2: lithium chloride / N,N-dimethyl-formamide / 6 h / Reflux
3: sodium carbonate; sodium dithionite; water / 1 h / 20 °C
4: trifluoroacetic acid / toluene / 6 h / 80 °C
5: triethylamine; pyridine / 2 h / 20 °C / Inert atmosphere
6: hydrogenchloride; water / 3 h / 20 - 70 °C
View Scheme
1-(5-methoxy-2-nitrophenyl)propan-1-one

1-(5-methoxy-2-nitrophenyl)propan-1-one

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: lithium chloride / N,N-dimethyl-formamide / 6 h / Reflux
2: sodium carbonate; sodium dithionite; water / 1 h / 20 °C
3: trifluoroacetic acid / toluene / 6 h / 80 °C
4: triethylamine; pyridine / 2 h / 20 °C / Inert atmosphere
5: hydrogenchloride; water / 3 h / 20 - 70 °C
View Scheme
1-(5-hydroxy-2-nitrophenyl)propan-1-one
453518-19-9

1-(5-hydroxy-2-nitrophenyl)propan-1-one

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium carbonate; sodium dithionite; water / 1 h / 20 °C
2: trifluoroacetic acid / toluene / 6 h / 80 °C
3: triethylamine; pyridine / 2 h / 20 °C / Inert atmosphere
4: hydrogenchloride; water / 3 h / 20 - 70 °C
View Scheme
3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1.1: hydroxylamine hydrochloride; sodium hydroxide; water / ethanol / 4 h / 5 °C
2.1: acetic anhydride / 2 h / 110 °C
3.1: magnesium / tetrahydrofuran / 0.5 h / 40 °C
3.2: 1 h / 40 °C
4.1: nitric acid / dichloromethane / 12 h / 10 - 20 °C
5.1: sodium hydroxide / 2 h / 0 - 20 °C
6.1: lithium chloride / N,N-dimethyl-formamide / 6 h / Reflux
7.1: sodium carbonate; sodium dithionite; water / 1 h / 20 °C
8.1: trifluoroacetic acid / toluene / 6 h / 80 °C
9.1: triethylamine; pyridine / 2 h / 20 °C / Inert atmosphere
10.1: hydrogenchloride; water / 3 h / 20 - 70 °C
View Scheme
3-fluorobenzaldehyde oxime
458-02-6

3-fluorobenzaldehyde oxime

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: acetic anhydride / 2 h / 110 °C
2.1: magnesium / tetrahydrofuran / 0.5 h / 40 °C
2.2: 1 h / 40 °C
3.1: nitric acid / dichloromethane / 12 h / 10 - 20 °C
4.1: sodium hydroxide / 2 h / 0 - 20 °C
5.1: lithium chloride / N,N-dimethyl-formamide / 6 h / Reflux
6.1: sodium carbonate; sodium dithionite; water / 1 h / 20 °C
7.1: trifluoroacetic acid / toluene / 6 h / 80 °C
8.1: triethylamine; pyridine / 2 h / 20 °C / Inert atmosphere
9.1: hydrogenchloride; water / 3 h / 20 - 70 °C
View Scheme
m-Fluorobenzonitrile
403-54-3

m-Fluorobenzonitrile

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: magnesium / tetrahydrofuran / 0.5 h / 40 °C
1.2: 1 h / 40 °C
2.1: nitric acid / dichloromethane / 12 h / 10 - 20 °C
3.1: sodium hydroxide / 2 h / 0 - 20 °C
4.1: lithium chloride / N,N-dimethyl-formamide / 6 h / Reflux
5.1: sodium carbonate; sodium dithionite; water / 1 h / 20 °C
6.1: trifluoroacetic acid / toluene / 6 h / 80 °C
7.1: triethylamine; pyridine / 2 h / 20 °C / Inert atmosphere
8.1: hydrogenchloride; water / 3 h / 20 - 70 °C
View Scheme
1-(3-fluorophenyl)propan-1-one
455-67-4

1-(3-fluorophenyl)propan-1-one

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: nitric acid / dichloromethane / 12 h / 10 - 20 °C
2: sodium hydroxide / 2 h / 0 - 20 °C
3: lithium chloride / N,N-dimethyl-formamide / 6 h / Reflux
4: sodium carbonate; sodium dithionite; water / 1 h / 20 °C
5: trifluoroacetic acid / toluene / 6 h / 80 °C
6: triethylamine; pyridine / 2 h / 20 °C / Inert atmosphere
7: hydrogenchloride; water / 3 h / 20 - 70 °C
View Scheme
4-piperidinopiperidine-1-carbonyl chloride
103816-19-9

4-piperidinopiperidine-1-carbonyl chloride

7-ethyl-10-hydroxycamptothecin
86639-52-3, 110714-48-2, 130144-34-2

7-ethyl-10-hydroxycamptothecin

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

Conditions
ConditionsYield
Stage #1: 4-piperidinopiperidine-1-carbonyl chloride; 7-ethyl-10-hydroxycamptothecin With dmap; triethylamine In dichloromethane at 20℃;
Stage #2: With hydrogenchloride In methanol pH=1 - 2; Reagent/catalyst;
14.1 g
4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
102978-40-5

4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: toluene-4-sulfonic acid / toluene / 5 h / Reflux
2.1: lithium hydroxide / methanol; water / 1 h / 25 - 30 °C
2.2: 18 - 22 °C
3.1: sulfuric acid / 2 h / 0 - 5 °C
4.1: triethylamine; pyridine / dichloromethane / 20 - 40 °C
4.2: pH 2-3
View Scheme
4,11-diethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14 (4H,12H)-dione
130144-34-2

4,11-diethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14 (4H,12H)-dione

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: lithium hydroxide / methanol; water / 1 h / 25 - 30 °C
1.2: 18 - 22 °C
2.1: sulfuric acid / 2 h / 0 - 5 °C
3.1: triethylamine; pyridine / dichloromethane / 20 - 40 °C
3.2: pH 2-3
View Scheme
camptothecin
7689-03-4

camptothecin

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: ferrous(II) sulfate heptahydrate; sulfuric acid; acetic acid / water / 5 °C
1.2: 0.25 h / 5 °C
2.1: acetic acid; dihydrogen peroxide / 8 h / 80 °C
3.1: sulfuric acid; water / 1,4-dioxane; acetonitrile / Inert atmosphere; Irradiation
4.1: dichloromethane / 6 h / 45 - 50 °C
5.1: hydrogenchloride / water / 12 h / 20 °C
View Scheme
7-ethylcamptothecin
78287-27-1

7-ethylcamptothecin

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: acetic acid; dihydrogen peroxide / 8 h / 80 °C
2: sulfuric acid; water / 1,4-dioxane; acetonitrile / Inert atmosphere; Irradiation
3: dichloromethane / 6 h / 45 - 50 °C
4: hydrogenchloride / water / 12 h / 20 °C
View Scheme
7-Ethylcamptothecin 1-Oxide
86639-51-2

7-Ethylcamptothecin 1-Oxide

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sulfuric acid; water / 1,4-dioxane; acetonitrile / Inert atmosphere; Irradiation
2: dichloromethane / 6 h / 45 - 50 °C
3: hydrogenchloride / water / 12 h / 20 °C
View Scheme
N-(t-butoxycarbonyl)glycinal
89711-08-0

N-(t-butoxycarbonyl)glycinal

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

t-boc-glycine-irinotecan hydrochloride

t-boc-glycine-irinotecan hydrochloride

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 17℃; Inert atmosphere;95%
2-azidoacetic acid
18523-48-3

2-azidoacetic acid

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

C35H39N7O7*ClH

C35H39N7O7*ClH

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane; acetonitrile at 0 - 20℃; Inert atmosphere;95%
irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

14-azido-3,6,9,12-tetraoxa-1-tetradecanoic acid
201467-81-4

14-azido-3,6,9,12-tetraoxa-1-tetradecanoic acid

20-O-(14-azido-4,7,10,13-tetraoxattetradecanoyl)irinotecan

20-O-(14-azido-4,7,10,13-tetraoxattetradecanoyl)irinotecan

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane Inert atmosphere;90%
irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

irinotecan hydrochloride trihydrate
136572-09-3

irinotecan hydrochloride trihydrate

Conditions
ConditionsYield
With hydrogenchloride; water In ethanol at 75 - 80℃;87%
With water In ethanol Heating / reflux;
triethylammonium sucrose octasulfate

triethylammonium sucrose octasulfate

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

irinotecan sucrosofate

irinotecan sucrosofate

Conditions
ConditionsYield
With hydrogenchloride In water at 65℃; for 0.0833333h;84%
C21H27FNO5P

C21H27FNO5P

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

C54H63FN5O10P

C54H63FN5O10P

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 30℃;77.1%
2-(4-(((4-bromophenyl)(diethoxyphosphoryl)methyl)amino)phenyl)acetic acid

2-(4-(((4-bromophenyl)(diethoxyphosphoryl)methyl)amino)phenyl)acetic acid

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

C52H59BrN5O10P

C52H59BrN5O10P

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 30℃;76.7%
2-(4-(((3-bromophenyl)(diethoxyphosphoryl)methyl)amino)phenyl)acetic acid

2-(4-(((3-bromophenyl)(diethoxyphosphoryl)methyl)amino)phenyl)acetic acid

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

C52H59BrN5O10P

C52H59BrN5O10P

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 30℃;74.3%
C21H27BrNO5P

C21H27BrNO5P

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

C54H63BrN5O10P

C54H63BrN5O10P

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 30℃;73.7%
2-(4-(((diethoxyphosphoryl)(4-fluorophenyl)methyl)amino)phenyl)acetic acid

2-(4-(((diethoxyphosphoryl)(4-fluorophenyl)methyl)amino)phenyl)acetic acid

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

C52H59FN5O10P

C52H59FN5O10P

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 30℃;73.5%
1,4-oxathiane-2,6-dione
3261-87-8

1,4-oxathiane-2,6-dione

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

C37H42N4O9S

C37H42N4O9S

Conditions
ConditionsYield
Stage #1: irinotecan hydrochloirde With dmap In dichloromethane for 0.166667h;
Stage #2: 1,4-oxathiane-2,6-dione With dmap In dichloromethane at 20℃; for 19h;
73%
C21H27FNO5P

C21H27FNO5P

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

C54H63FN5O10P

C54H63FN5O10P

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 30℃;72.8%
C21H27BrNO5P

C21H27BrNO5P

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

C54H63BrN5O10P

C54H63BrN5O10P

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 30℃;71%
C19H23ClNO5P

C19H23ClNO5P

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

C52H59ClN5O10P

C52H59ClN5O10P

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 30℃;70.5%
C19H23ClNO5P

C19H23ClNO5P

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

C52H59ClN5O10P

C52H59ClN5O10P

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 30℃;69.5%
C22H30NO6P

C22H30NO6P

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

C55H66N5O11P

C55H66N5O11P

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 30℃;69%
C21H27ClNO5P

C21H27ClNO5P

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

C54H63ClN5O10P

C54H63ClN5O10P

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 30℃;67.6%
2-(4-(((diethoxyphosphoryl)(phenyl)methyl)amino)phenyl)acetic acid

2-(4-(((diethoxyphosphoryl)(phenyl)methyl)amino)phenyl)acetic acid

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

C52H60N5O10P

C52H60N5O10P

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 30℃;67.2%
6-azidohexanoic acid
79598-53-1

6-azidohexanoic acid

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

C39H47N7O7

C39H47N7O7

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane; acetonitrile at 20℃;67%
C21H28NO5P

C21H28NO5P

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

C54H64N5O10P

C54H64N5O10P

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 30℃;66.7%
C22H30NO5P

C22H30NO5P

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

C55H66N5O10P

C55H66N5O10P

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 30℃;65.7%
C21H27ClNO5P

C21H27ClNO5P

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

C54H63ClN5O10P

C54H63ClN5O10P

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 30℃;65.7%
2-(4-(((diethoxyphosphoryl)(4-methoxyphenyl)methyl)amino)phenyl)acetic acid

2-(4-(((diethoxyphosphoryl)(4-methoxyphenyl)methyl)amino)phenyl)acetic acid

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

C53H62N5O11P

C53H62N5O11P

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 30℃;63.8%
C22H30NO6P

C22H30NO6P

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

C55H66N5O11P

C55H66N5O11P

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 30℃;60.5%
2-(4-(((diethoxyphosphoryl)(3-fluorophenyl)methyl)amino)phenyl)acetic acid

2-(4-(((diethoxyphosphoryl)(3-fluorophenyl)methyl)amino)phenyl)acetic acid

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

C52H59FN5O10P

C52H59FN5O10P

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 30℃;60.3%
2-(4-(((diethoxyphosphoryl)(3-methoxyphenyl)methyl)amino)phenyl)acetic acid

2-(4-(((diethoxyphosphoryl)(3-methoxyphenyl)methyl)amino)phenyl)acetic acid

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

C53H62N5O11P

C53H62N5O11P

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 30℃;57.8%
C20H26NO5P

C20H26NO5P

irinotecan hydrochloirde
100286-90-6

irinotecan hydrochloirde

C53H62N5O10P

C53H62N5O10P

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 30℃;57.4%

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