Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
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inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is
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inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine chemicals, ph
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryStorage:room temperature Package:25kg/drum Application:Chemicals Transportation:Express/Sea/Air Port:any port in china
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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inquiryWe Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O
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inquiryHigh quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
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inquirySuperior quality, moderate price & quick delivery. Appearance:white crystalline powder Storage:Sealed in a cool ,dry and microtherm place , avoid light . Package:100g/bottle,1kg/bottle,25kg/drum or as per your request Application:It is an impo
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inquiryTAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp
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inquiryTIANFU CHEM---Ethanone, 2-bromo-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-Appearance:Colorless to light yellow liquid Storage:Room temperature Package:20kg/drum, 200kg/drum or 1000kg/IBC Drum Application:Water treatment Transportation:By sea , by air
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inquiryWe product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:Chemical intermediate
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inquirybulk productionChemsigma International Co.,Ltd. is a chemical manufacturer, specialize in custom synthesis and organic chemical manufacturing for overseas customers, in the field of API, pharmaceutical intermediates, chemical intermediates, fine chem
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inquiryEthanone, 2-bromo-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:pharmaceutical intermediate Transportation:by air, by sea, by express
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inquiryBest Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP
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inquiry2-Methoxypropene
2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In dichloromethane at 0℃; for 0.666667h; | 100% |
With resin-SO3H In dichloromethane | |
With toluene-4-sulfonic acid In tetrahydrofuran at -10 - 10℃; for 1h; |
2,2-dimethoxy-propane
2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In dichloromethane | 99% |
With toluene-4-sulfonic acid In dichloromethane at 20℃; | 84% |
In dichloromethane at 20℃; for 10h; | 82% |
1-(2,2-dimethyl-4H-benzo[d][1,3]dioxan-6-yl)ethanone
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
Conditions | Yield |
---|---|
With bromine In diethyl ether at 10 - 15℃; for 2.33333h; | 81.03% |
Stage #1: 1-(2,2-dimethyl-4H-benzo[d][1,3]dioxan-6-yl)ethanone With sodium hexamethyldisilazane In tetrahydrofuran at -78℃; for 1h; Stage #2: With chloro-trimethyl-silane In tetrahydrofuran at -78℃; for 0.5h; Stage #3: With bromine In tetrahydrofuran at -78℃; for 1h; | 57% |
Stage #1: 1-(2,2-dimethyl-4H-benzo[d][1,3]dioxan-6-yl)ethanone With sodium hexamethyldisilazane In tetrahydrofuran at -75 - -70℃; for 1h; Stage #2: With chloro-trimethyl-silane; bromine In tetrahydrofuran at -75 - -70℃; | 55% |
4'-acetoxy-3'-(acetoxymethyl)acetophenone
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: polyvinylpyridinium bromide perbromide resin / CH2Cl2 2: 1N HBr / tetrahydrofuran / 75 °C 3: resin-SO3H / CH2Cl2 View Scheme |
3'-acetoxymethyl-4'-acetoxy-2-bromoacetophenone
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1N HBr / tetrahydrofuran / 75 °C 2: resin-SO3H / CH2Cl2 View Scheme |
4-Hydroxyacetophenone
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: resin-bound piperazinomethylpolystyrene / H2O; tetrahydrofuran 1.2: 14 percent / pTSA / toluene / 110 °C 2.1: polyvinylpyridinium bromide perbromide resin / CH2Cl2 3.1: 1N HBr / tetrahydrofuran / 75 °C 4.1: resin-SO3H / CH2Cl2 View Scheme |
salicylaldehyde
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: aluminum (III) chloride / dichloromethane / 15 h / Reflux 2: sodium tetrahydroborate; acetic acid / 1 h / 10 °C 3: dichloromethane / 10 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: aluminum (III) chloride / dichloromethane / 0.5 h / 50 °C 1.2: 12 h / 40 °C 2.1: sodium tetrahydroborate; acetic acid / 0 - 20 °C / Inert atmosphere 3.1: toluene-4-sulfonic acid / dichloromethane / 20 °C View Scheme |
5-(2-bromoacetyl)-2-hydroxybenzaldehyde
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium tetrahydroborate; acetic acid / 1 h / 10 °C 2: dichloromethane / 10 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: sodium tetrahydroborate; acetic acid / 0 - 20 °C / Inert atmosphere 2: toluene-4-sulfonic acid / dichloromethane / 20 °C View Scheme |
5-bromo-2-hydroxybenzyl alcohol
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: acetone 2: n-butyllithium / tetrahydrofuran 3: sodium hexamethyldisilazane / tetrahydrofuran 4: bromine View Scheme | |
Multi-step reaction with 3 steps 1.1: aluminum (III) chloride / tetrahydrofuran / 1 h / 0 - 30 °C / Inert atmosphere 2.1: n-butyllithium / tetrahydrofuran / 1 h / -75 - -70 °C 2.2: -75 - -70 °C 3.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -75 - -70 °C 3.2: -75 - -70 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 20 °C 2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere 2.2: 4 h / -78 °C / Inert atmosphere 3.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C 3.2: 1 h / -78 °C 3.3: 1 h / -78 °C View Scheme |
6-bromo-2,2-dimethyl-4H-benzo[1,3]dioxine
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: n-butyllithium / tetrahydrofuran 2: sodium hexamethyldisilazane / tetrahydrofuran 3: bromine View Scheme | |
Multi-step reaction with 2 steps 1.1: n-butyllithium / tetrahydrofuran / 1 h / -75 - -70 °C 1.2: -75 - -70 °C 2.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -75 - -70 °C 2.2: -75 - -70 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere 1.2: 4 h / -78 °C / Inert atmosphere 2.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C 2.2: 1 h / -78 °C 2.3: 1 h / -78 °C View Scheme |
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
Conditions | Yield |
---|---|
With bromine |
5-bromosalicyclaldehyde
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sodium tetrahydroborate; ethanol / 5 h / 0 - 20 °C 2.1: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 20 °C 3.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere 3.2: 4 h / -78 °C / Inert atmosphere 4.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C 4.2: 1 h / -78 °C 4.3: 1 h / -78 °C View Scheme |
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
2-azido-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanone
Conditions | Yield |
---|---|
With sodium azide In N,N-dimethyl-formamide at 20 - 30℃; for 2h; | 97% |
With sodium azide In N,N-dimethyl-formamide at 20℃; for 2h; | 95% |
With sodium azide In N,N-dimethyl-formamide at 20℃; for 2h; | 89% |
With sodium azide In DMF (N,N-dimethyl-formamide) at 20℃; for 2h; | |
With sodium azide In DMF (N,N-dimethyl-formamide) at 20℃; for 2h; |
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
Conditions | Yield |
---|---|
With sodium formate; η5-pentamethylcyclopentadienylrhodium dimer In water at 20℃; for 12h; | 93% |
With 2-(morpholin-4-yl)ethanol; β-nicotinamide adenine dinucleotide phosphate disodium salt; alcohol dehydrogenase CDX-005; nitric acid In water; dimethyl sulfoxide; isopropyl alcohol at 25℃; for 24h; Reagent/catalyst; Solvent; Large scale; Enzymatic reaction; | 86.7% |
With (1R,2S)-1-Amino-2-indanol; dimethyl sulfide borane In tetrahydrofuran at 20 - 25℃; for 3.5h; | 76.12% |
tert-butylamine
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
Conditions | Yield |
---|---|
With potassium carbonate In tetrahydrofuran; water | 93% |
(2S)-2-phenylglycinol
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
(1'S)-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-2-(2-hydroxy-1-phenyl-ethylamino)-ethanone
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran for 4h; | 80% |
With resin-N(iPr)2 In tetrahydrofuran |
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
(R)-2-Bromo-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)ethanol
Conditions | Yield |
---|---|
Stage #1: 2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone With sodium tetrahydroborate In methanol at 0℃; for 0.5h; Stage #2: With ammonium chloride In methanol; water at 0℃; | 79% |
With sodium tetrahydroborate In methanol at 0 - 20℃; for 1h; |
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 12h; | 71% |
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 12h; | 70% |
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 12h; | 68% |
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 12h; | 65% |
(S)-2-methoxy-1-phenylethylamine
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-[(1S)-2-methoxy-1-phenylethylamino]ethanone
Conditions | Yield |
---|---|
With polystyryldiisopropylethylamine In tetrahydrofuran for 2h; | 64% |
iminodicarboxylic acid di-tert-butyl ester
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
di-(tert-butyl) 2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-oxoethyliminodicarbonate
Conditions | Yield |
---|---|
With caesium carbonate In acetonitrile at 20 - 25℃; for 6h; Inert atmosphere; | 64% |
With caesium carbonate In acetonitrile at 21℃; for 24h; | 28% |
With caesium carbonate In acetonitrile at 21℃; for 24h; |
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 28 percent / Cs2CO3 / acetonitrile / 24 h / 21 °C 2: 43 percent / CF3CO2H / CH2Cl2 / 4 h / 20 °C 3: 99 percent / (R)-tetrahydro-1-Me-3,3-Ph2-1H,3H-pyrrolo[1,2-c][1,3-2]oxaza; borole; BH3*THF / toluene / 5 - 20 °C 4: 70 percent / NaH / dimethylformamide / 3 h / 20 °C 5: 77 percent / NaH / dimethylformamide / 4 h / 5 - 20 °C 6: 96 percent / KOSiMe3 / tetrahydrofuran / 1 h / Heating 7: 80 percent / AcOH; MeOH / 72 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: resin-N(iPr)2 / tetrahydrofuran 2.1: CaCl2 / methanol / 0.17 h / 0 °C 2.2: 76 percent / resin-NMe3(1+)*BH4(1-) / methanol / 2 h / 0 - 20 °C 3.1: (polystyrylmethyl)trimethylammonium cyanoborohydride; AcOH / CH2Cl2 3.2: 98 percent / resin-NMe3(1+)*NaCO3(1-) / CH2Cl2 4.1: H2 / Pd(OH)2/C / ethyl acetate / 2 h 4.2: 87 percent / SCX-2 View Scheme |
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
(R)-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-(6-(4-phenylbutoxy)hexylamino)ethanol
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 28 percent / Cs2CO3 / acetonitrile / 24 h / 21 °C 2: 43 percent / CF3CO2H / CH2Cl2 / 4 h / 20 °C 3: 99 percent / (R)-tetrahydro-1-Me-3,3-Ph2-1H,3H-pyrrolo[1,2-c][1,3-2]oxaza; borole; BH3*THF / toluene / 5 - 20 °C 4: 70 percent / NaH / dimethylformamide / 3 h / 20 °C 5: 77 percent / NaH / dimethylformamide / 4 h / 5 - 20 °C 6: 96 percent / KOSiMe3 / tetrahydrofuran / 1 h / Heating View Scheme | |
Multi-step reaction with 4 steps 1: 80 percent / i-Pr2NEt / tetrahydrofuran / 4 h 2: 76 percent / CaCl2*2H2O; NaBH4 / methanol / 2 h / 0 °C 3: 87 percent / sodium triacetoxyborohydride / CH2Cl2 / 18 h 4: 87 percent / H2 / aq. Pd(OH)2/C / ethanol / 18 h View Scheme |
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
(5R)-5-(2,2-dimethyl- 4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 28 percent / Cs2CO3 / acetonitrile / 24 h / 21 °C 2: 43 percent / CF3CO2H / CH2Cl2 / 4 h / 20 °C 3: 99 percent / (R)-tetrahydro-1-Me-3,3-Ph2-1H,3H-pyrrolo[1,2-c][1,3-2]oxaza; borole; BH3*THF / toluene / 5 - 20 °C 4: 70 percent / NaH / dimethylformamide / 3 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1: caesium carbonate / acetonitrile / 6 h / 20 - 25 °C / Inert atmosphere 2: trifluoroacetic acid / dichloromethane / 5 h / 10 - 25 °C 3: dimethylsulfide borane complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran; toluene / 1 h / -10 °C 4: potassium tert-butylate / N,N-dimethyl-formamide / 1 h / 10 - 20 °C View Scheme | |
Multi-step reaction with 4 steps 1: caesium carbonate / acetonitrile / 20 °C 2: trifluoroacetic acid / dichloromethane / 2 h / 10 °C 3: (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; dimethylsulfide borane complex / toluene; tetrahydrofuran / 0.67 h / -10 °C / Inert atmosphere 4: potassium tert-butylate / N,N-dimethyl-formamide / 3 h / 0 - 20 °C / Inert atmosphere View Scheme |
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
tert-butyl 2-(2,2-dimethyl-4H-1,3-benzodioxane-6-yl)-2-carbonylethylcarbamate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 28 percent / Cs2CO3 / acetonitrile / 24 h / 21 °C 2: 43 percent / CF3CO2H / CH2Cl2 / 4 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: caesium carbonate / acetonitrile / 6 h / 20 - 25 °C / Inert atmosphere 2: trifluoroacetic acid / dichloromethane / 5 h / 10 - 25 °C View Scheme | |
Multi-step reaction with 2 steps 1: caesium carbonate / acetonitrile / 20 °C 2: trifluoroacetic acid / dichloromethane / 2 h / 10 °C View Scheme |
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
tert-butyl (2R)-2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-hydroxyethylcarbamate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 28 percent / Cs2CO3 / acetonitrile / 24 h / 21 °C 2: 43 percent / CF3CO2H / CH2Cl2 / 4 h / 20 °C 3: 99 percent / (R)-tetrahydro-1-Me-3,3-Ph2-1H,3H-pyrrolo[1,2-c][1,3-2]oxaza; borole; BH3*THF / toluene / 5 - 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: caesium carbonate / acetonitrile / 6 h / 20 - 25 °C / Inert atmosphere 2: trifluoroacetic acid / dichloromethane / 5 h / 10 - 25 °C 3: dimethylsulfide borane complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran; toluene / 1 h / -10 °C View Scheme | |
Multi-step reaction with 3 steps 1: caesium carbonate / acetonitrile / 20 °C 2: trifluoroacetic acid / dichloromethane / 2 h / 10 °C 3: (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; dimethylsulfide borane complex / toluene; tetrahydrofuran / 0.67 h / -10 °C / Inert atmosphere View Scheme |
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
(5R)-5-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-3-[6-(4-phenylbutoxy)hexyl]-1,3-oxazolidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 28 percent / Cs2CO3 / acetonitrile / 24 h / 21 °C 2: 43 percent / CF3CO2H / CH2Cl2 / 4 h / 20 °C 3: 99 percent / (R)-tetrahydro-1-Me-3,3-Ph2-1H,3H-pyrrolo[1,2-c][1,3-2]oxaza; borole; BH3*THF / toluene / 5 - 20 °C 4: 70 percent / NaH / dimethylformamide / 3 h / 20 °C 5: 77 percent / NaH / dimethylformamide / 4 h / 5 - 20 °C View Scheme |
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 64 percent / polystyryldiisopropylethylamine / tetrahydrofuran / 2 h 2: 91 percent / CaCl2; polystyryl(trimethyl)ammonium borohydride / methanol / 2 h / 0 - 20 °C View Scheme |
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 80 percent / i-Pr2NEt / tetrahydrofuran / 4 h 2: CaCl2*2H2O; NaBH4 / methanol / 2 h / 0 °C View Scheme |
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
(1R,1'S)-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-2-(2-hydroxy-1-phenyl-ethylamino)-ethanol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 80 percent / i-Pr2NEt / tetrahydrofuran / 4 h 2: 76 percent / CaCl2*2H2O; NaBH4 / methanol / 2 h / 0 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: resin-N(iPr)2 / tetrahydrofuran 2.1: CaCl2 / methanol / 0.17 h / 0 °C 2.2: 76 percent / resin-NMe3(1+)*BH4(1-) / methanol / 2 h / 0 - 20 °C View Scheme |
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 80 percent / i-Pr2NEt / tetrahydrofuran / 4 h 2: 91 percent / CH2Cl2 / 0.25 h 3: 87 percent / CaCl2; polystyryl(trimethyl)ammonium borohydride / methanol / 2 h / 0 - 20 °C View Scheme |
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
(4S)-3-[2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-oxoethyl]-4-phenyl-1,3-oxazolidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 80 percent / i-Pr2NEt / tetrahydrofuran / 4 h 2: 91 percent / CH2Cl2 / 0.25 h View Scheme |
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
(1R,1'S)-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-2-{(2-hydroxy-1-phenyl-ethyl)-[6-(4-phenyl-butoxy)-hexyl]-amino}-ethanol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 80 percent / i-Pr2NEt / tetrahydrofuran / 4 h 2: 76 percent / CaCl2*2H2O; NaBH4 / methanol / 2 h / 0 °C 3: 87 percent / sodium triacetoxyborohydride / CH2Cl2 / 18 h View Scheme | |
Multi-step reaction with 3 steps 1.1: resin-N(iPr)2 / tetrahydrofuran 2.1: CaCl2 / methanol / 0.17 h / 0 °C 2.2: 76 percent / resin-NMe3(1+)*BH4(1-) / methanol / 2 h / 0 - 20 °C 3.1: (polystyrylmethyl)trimethylammonium cyanoborohydride; AcOH / CH2Cl2 3.2: 98 percent / resin-NMe3(1+)*NaCO3(1-) / CH2Cl2 View Scheme |
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: resin-N(iPr)2 / tetrahydrofuran 2.1: CaCl2 / methanol / 0.17 h / 0 °C 2.2: 76 percent / resin-NMe3(1+)*BH4(1-) / methanol / 2 h / 0 - 20 °C 3.1: H2 / Pd(OH)2/C / ethyl acetate View Scheme |
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