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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

6-Bromoacetyl-2,2-dimethyl-4H-benzo[1,3]dioxine

Cas:102293-80-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-Bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-ethanone

Cas:102293-80-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFU CHEM---Ethanone, 2-bromo-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-

Cas:102293-80-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Ethanone, 2-bromo-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-

Cas:102293-80-1

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 102293-80-1 with competitive price

Cas:102293-80-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

Ethanone, 2-bromo-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl) CAS NO 102293-80-1

Cas:102293-80-1

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine chemicals, ph

2-Bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

Cas:102293-80-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Ethanone, 2-bromo-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)- 102293-80-1

Cas:102293-80-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Storage:room temperature Package:25kg/drum Application:Chemicals Transportation:Express/Sea/Air Port:any port in china

2-Bromo-1-(2,2-dimethyl-4h-1,3-benzodioxin-6-yl)ethanone

Cas:102293-80-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Ethanone, 2-bromo-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-

Cas:102293-80-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

high purity 2-BROMO-1-(2,2-DIMETHYL-4H-1,3-BENZODIOXIN-6-YL)ETHANONE

Cas:102293-80-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Ethanone, 2-bromo-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-

Cas:102293-80-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

2-BROMO-1-(2,2-DIMETHYL-4H-1,3-BENZODIOXIN-6-YL)ETHANONE

Cas:102293-80-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

Ethanone, 2-bromo-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-

Cas:102293-80-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

6-Bromoacetyl-2,2-dimethyl-4H-benzo[1,3]dioxine

Cas:102293-80-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

2-bromo-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-Ethanone

Cas:102293-80-1

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

Ethanone, 2-broMo-1-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-

Cas:102293-80-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white crystalline powder Storage:Sealed in a cool ,dry and microtherm place , avoid light . Package:100g/bottle,1kg/bottle,25kg/drum or as per your request Application:It is an impo

2-bromo-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanone supplier in China

Cas:102293-80-1

Min.Order:100 Gram

Negotiable

Type:Trading Company

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

Ethanone, 2-bromo-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-

Cas:102293-80-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

2-Bromo-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanone

Cas:102293-80-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

Ethanone, 2-bromo-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-

Cas:102293-80-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

TIANFU CHEM---Ethanone, 2-bromo-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-Appearance:Colorless to light yellow liquid Storage:Room temperature Package:20kg/drum, 200kg/drum or 1000kg/IBC Drum Application:Water treatment Transportation:By sea , by air

TIANFU CHEM---Ethanone, 2-bromo-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-

Cas:102293-80-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU TIANYE CHEMICALS CO., LTD.

We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:Chemical intermediate

2-bromo-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanone

Cas:102293-80-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemsigma International Co.,Ltd.

bulk productionChemsigma International Co.,Ltd. is a chemical manufacturer, specialize in custom synthesis and organic chemical manufacturing for overseas customers, in the field of API, pharmaceutical intermediates, chemical intermediates, fine chem

6-Bromoacetyl-2,2-dimethyl-4H-benzo[1,3]dioxine

Cas:102293-80-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Circle Star Chem-medical Technology co.,Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:25kg,50kg,180kg,200kg,250kg,1000kg,customization Application:Pharma;Industry;Agricultural;chemical reaserch Tran

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

Cas:102293-80-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fandachem Co.,Ltd

Ethanone, 2-bromo-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:pharmaceutical intermediate Transportation:by air, by sea, by express

Ethanone, 2-bromo-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-

Cas:102293-80-1

Min.Order:0

Negotiable

Type:Other

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

Ethanone, 2-bromo-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-

Cas:102293-80-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemlyte Solutions

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

2-BROMO-1-(2,2-DIMETHYL-4H-1,3-BENZODIOXIN-6-YL)ETHANONE

Cas:102293-80-1

Min.Order:0

Negotiable

Type:Other

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

Ethanone, 2-bromo-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-

Cas:102293-80-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

LEAP CHEM Co., Ltd.

Best Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP

Ethanone, 2-bromo-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-

Cas:102293-80-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

2-Methoxypropene
116-11-0

2-Methoxypropene

2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone
62932-94-9

2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
102293-80-1

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

Conditions
ConditionsYield
With toluene-4-sulfonic acid In dichloromethane at 0℃; for 0.666667h;100%
With resin-SO3H In dichloromethane
With toluene-4-sulfonic acid In tetrahydrofuran at -10 - 10℃; for 1h;
2,2-dimethoxy-propane
77-76-9

2,2-dimethoxy-propane

2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone
62932-94-9

2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
102293-80-1

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

Conditions
ConditionsYield
With toluene-4-sulfonic acid In dichloromethane99%
With toluene-4-sulfonic acid In dichloromethane at 20℃;84%
In dichloromethane at 20℃; for 10h;82%
1-(2,2-dimethyl-4H-benzo[d][1,3]dioxan-6-yl)ethanone
54030-34-1

1-(2,2-dimethyl-4H-benzo[d][1,3]dioxan-6-yl)ethanone

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
102293-80-1

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

Conditions
ConditionsYield
With bromine In diethyl ether at 10 - 15℃; for 2.33333h;81.03%
Stage #1: 1-(2,2-dimethyl-4H-benzo[d][1,3]dioxan-6-yl)ethanone With sodium hexamethyldisilazane In tetrahydrofuran at -78℃; for 1h;
Stage #2: With chloro-trimethyl-silane In tetrahydrofuran at -78℃; for 0.5h;
Stage #3: With bromine In tetrahydrofuran at -78℃; for 1h;
57%
Stage #1: 1-(2,2-dimethyl-4H-benzo[d][1,3]dioxan-6-yl)ethanone With sodium hexamethyldisilazane In tetrahydrofuran at -75 - -70℃; for 1h;
Stage #2: With chloro-trimethyl-silane; bromine In tetrahydrofuran at -75 - -70℃;
55%
4'-acetoxy-3'-(acetoxymethyl)acetophenone
24085-06-1

4'-acetoxy-3'-(acetoxymethyl)acetophenone

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
102293-80-1

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: polyvinylpyridinium bromide perbromide resin / CH2Cl2
2: 1N HBr / tetrahydrofuran / 75 °C
3: resin-SO3H / CH2Cl2
View Scheme
3'-acetoxymethyl-4'-acetoxy-2-bromoacetophenone
24085-07-2

3'-acetoxymethyl-4'-acetoxy-2-bromoacetophenone

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
102293-80-1

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1N HBr / tetrahydrofuran / 75 °C
2: resin-SO3H / CH2Cl2
View Scheme
4-Hydroxyacetophenone
99-93-4

4-Hydroxyacetophenone

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
102293-80-1

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: resin-bound piperazinomethylpolystyrene / H2O; tetrahydrofuran
1.2: 14 percent / pTSA / toluene / 110 °C
2.1: polyvinylpyridinium bromide perbromide resin / CH2Cl2
3.1: 1N HBr / tetrahydrofuran / 75 °C
4.1: resin-SO3H / CH2Cl2
View Scheme
salicylaldehyde
90-02-8

salicylaldehyde

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
102293-80-1

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: aluminum (III) chloride / dichloromethane / 15 h / Reflux
2: sodium tetrahydroborate; acetic acid / 1 h / 10 °C
3: dichloromethane / 10 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: aluminum (III) chloride / dichloromethane / 0.5 h / 50 °C
1.2: 12 h / 40 °C
2.1: sodium tetrahydroborate; acetic acid / 0 - 20 °C / Inert atmosphere
3.1: toluene-4-sulfonic acid / dichloromethane / 20 °C
View Scheme
5-(2-bromoacetyl)-2-hydroxybenzaldehyde
115787-50-3

5-(2-bromoacetyl)-2-hydroxybenzaldehyde

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
102293-80-1

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium tetrahydroborate; acetic acid / 1 h / 10 °C
2: dichloromethane / 10 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium tetrahydroborate; acetic acid / 0 - 20 °C / Inert atmosphere
2: toluene-4-sulfonic acid / dichloromethane / 20 °C
View Scheme
5-bromo-2-hydroxybenzyl alcohol
2316-64-5

5-bromo-2-hydroxybenzyl alcohol

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
102293-80-1

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: acetone
2: n-butyllithium / tetrahydrofuran
3: sodium hexamethyldisilazane / tetrahydrofuran
4: bromine
View Scheme
Multi-step reaction with 3 steps
1.1: aluminum (III) chloride / tetrahydrofuran / 1 h / 0 - 30 °C / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran / 1 h / -75 - -70 °C
2.2: -75 - -70 °C
3.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -75 - -70 °C
3.2: -75 - -70 °C
View Scheme
Multi-step reaction with 3 steps
1.1: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 20 °C
2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
2.2: 4 h / -78 °C / Inert atmosphere
3.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C
3.2: 1 h / -78 °C
3.3: 1 h / -78 °C
View Scheme
6-bromo-2,2-dimethyl-4H-benzo[1,3]dioxine
52113-69-6

6-bromo-2,2-dimethyl-4H-benzo[1,3]dioxine

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
102293-80-1

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: n-butyllithium / tetrahydrofuran
2: sodium hexamethyldisilazane / tetrahydrofuran
3: bromine
View Scheme
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran / 1 h / -75 - -70 °C
1.2: -75 - -70 °C
2.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -75 - -70 °C
2.2: -75 - -70 °C
View Scheme
Multi-step reaction with 2 steps
1.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
1.2: 4 h / -78 °C / Inert atmosphere
2.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C
2.2: 1 h / -78 °C
2.3: 1 h / -78 °C
View Scheme
C15H22O3Si

C15H22O3Si

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
102293-80-1

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

Conditions
ConditionsYield
With bromine
5-bromosalicyclaldehyde
1761-61-1

5-bromosalicyclaldehyde

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
102293-80-1

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium tetrahydroborate; ethanol / 5 h / 0 - 20 °C
2.1: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 20 °C
3.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
3.2: 4 h / -78 °C / Inert atmosphere
4.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C
4.2: 1 h / -78 °C
4.3: 1 h / -78 °C
View Scheme
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
102293-80-1

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

2-azido-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanone
384340-05-0

2-azido-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanone

Conditions
ConditionsYield
With sodium azide In N,N-dimethyl-formamide at 20 - 30℃; for 2h;97%
With sodium azide In N,N-dimethyl-formamide at 20℃; for 2h;95%
With sodium azide In N,N-dimethyl-formamide at 20℃; for 2h;89%
With sodium azide In DMF (N,N-dimethyl-formamide) at 20℃; for 2h;
With sodium azide In DMF (N,N-dimethyl-formamide) at 20℃; for 2h;
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
102293-80-1

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

(R)-2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanol

(R)-2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanol

Conditions
ConditionsYield
With sodium formate; η5-pentamethylcyclopentadienylrhodium dimer In water at 20℃; for 12h;93%
With 2-(morpholin-4-yl)ethanol; β-nicotinamide adenine dinucleotide phosphate disodium salt; alcohol dehydrogenase CDX-005; nitric acid In water; dimethyl sulfoxide; isopropyl alcohol at 25℃; for 24h; Reagent/catalyst; Solvent; Large scale; Enzymatic reaction;86.7%
With (1R,2S)-1-Amino-2-indanol; dimethyl sulfide borane In tetrahydrofuran at 20 - 25℃; for 3.5h;76.12%
tert-butylamine
75-64-9

tert-butylamine

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
102293-80-1

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

C16H23NO3

C16H23NO3

Conditions
ConditionsYield
With potassium carbonate In tetrahydrofuran; water93%
(2S)-2-phenylglycinol
20989-17-7

(2S)-2-phenylglycinol

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
102293-80-1

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

(1'S)-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-2-(2-hydroxy-1-phenyl-ethylamino)-ethanone
380414-67-5

(1'S)-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-2-(2-hydroxy-1-phenyl-ethylamino)-ethanone

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran for 4h;80%
With resin-N(iPr)2 In tetrahydrofuran
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
102293-80-1

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

(R)-2-Bromo-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)ethanol
956234-46-1

(R)-2-Bromo-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)ethanol

Conditions
ConditionsYield
Stage #1: 2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone With sodium tetrahydroborate In methanol at 0℃; for 0.5h;
Stage #2: With ammonium chloride In methanol; water at 0℃;
79%
With sodium tetrahydroborate In methanol at 0 - 20℃; for 1h;
C27H35N3O3

C27H35N3O3

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
102293-80-1

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

2-(4-(benzyl(2-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-oxoethyl)amino)butyl)-4-(3,4-dimethoxyphenyl)-4a,5,6,7,8,8a-hexahydrophthalazin-1(2H)-one

2-(4-(benzyl(2-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-oxoethyl)amino)butyl)-4-(3,4-dimethoxyphenyl)-4a,5,6,7,8,8a-hexahydrophthalazin-1(2H)-one

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 12h;71%
C28H37N3O3

C28H37N3O3

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
102293-80-1

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

2-(5-(benzyl(2-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-oxoethyl)amino)pentyl)-4-(3,4-dimethoxyphenyl)-4a,5,6,7,8,8a-hexahydrophthalazin-1(2H)-one

2-(5-(benzyl(2-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-oxoethyl)amino)pentyl)-4-(3,4-dimethoxyphenyl)-4a,5,6,7,8,8a-hexahydrophthalazin-1(2H)-one

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 12h;70%
C29H39N3O3

C29H39N3O3

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
102293-80-1

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

2-(6-(benzyl(2-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-oxoethyl)amino)hexyl)-4-(3,4-dimethoxyphenyl)-4a,5,6,7,8,8a-hexahydrophthalazin-1(2H)-one

2-(6-(benzyl(2-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-oxoethyl)amino)hexyl)-4-(3,4-dimethoxyphenyl)-4a,5,6,7,8,8a-hexahydrophthalazin-1(2H)-one

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 12h;68%
C25H31N3O3

C25H31N3O3

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
102293-80-1

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

cis-2-(3-(benzyl(2-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-oxoethyl)amino)propyl)-4-(3,4-dimethoxyphenyl)-4a,5,6,7,8,8a-hexahydrophthalazin-1(2H)-one

cis-2-(3-(benzyl(2-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-oxoethyl)amino)propyl)-4-(3,4-dimethoxyphenyl)-4a,5,6,7,8,8a-hexahydrophthalazin-1(2H)-one

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 12h;65%
(S)-2-methoxy-1-phenylethylamine
91298-74-7

(S)-2-methoxy-1-phenylethylamine

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
102293-80-1

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-[(1S)-2-methoxy-1-phenylethylamino]ethanone
500317-68-0

1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-[(1S)-2-methoxy-1-phenylethylamino]ethanone

Conditions
ConditionsYield
With polystyryldiisopropylethylamine In tetrahydrofuran for 2h;64%
iminodicarboxylic acid di-tert-butyl ester
51779-32-9

iminodicarboxylic acid di-tert-butyl ester

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
102293-80-1

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

di-(tert-butyl) 2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-oxoethyliminodicarbonate
452339-70-7

di-(tert-butyl) 2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-oxoethyliminodicarbonate

Conditions
ConditionsYield
With caesium carbonate In acetonitrile at 20 - 25℃; for 6h; Inert atmosphere;64%
With caesium carbonate In acetonitrile at 21℃; for 24h;28%
With caesium carbonate In acetonitrile at 21℃; for 24h;
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
102293-80-1

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

(R)-(-)-salmeterol

(R)-(-)-salmeterol

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 28 percent / Cs2CO3 / acetonitrile / 24 h / 21 °C
2: 43 percent / CF3CO2H / CH2Cl2 / 4 h / 20 °C
3: 99 percent / (R)-tetrahydro-1-Me-3,3-Ph2-1H,3H-pyrrolo[1,2-c][1,3-2]oxaza; borole; BH3*THF / toluene / 5 - 20 °C
4: 70 percent / NaH / dimethylformamide / 3 h / 20 °C
5: 77 percent / NaH / dimethylformamide / 4 h / 5 - 20 °C
6: 96 percent / KOSiMe3 / tetrahydrofuran / 1 h / Heating
7: 80 percent / AcOH; MeOH / 72 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: resin-N(iPr)2 / tetrahydrofuran
2.1: CaCl2 / methanol / 0.17 h / 0 °C
2.2: 76 percent / resin-NMe3(1+)*BH4(1-) / methanol / 2 h / 0 - 20 °C
3.1: (polystyrylmethyl)trimethylammonium cyanoborohydride; AcOH / CH2Cl2
3.2: 98 percent / resin-NMe3(1+)*NaCO3(1-) / CH2Cl2
4.1: H2 / Pd(OH)2/C / ethyl acetate / 2 h
4.2: 87 percent / SCX-2
View Scheme
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
102293-80-1

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

(R)-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-(6-(4-phenylbutoxy)hexylamino)ethanol
590410-69-8

(R)-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-(6-(4-phenylbutoxy)hexylamino)ethanol

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 28 percent / Cs2CO3 / acetonitrile / 24 h / 21 °C
2: 43 percent / CF3CO2H / CH2Cl2 / 4 h / 20 °C
3: 99 percent / (R)-tetrahydro-1-Me-3,3-Ph2-1H,3H-pyrrolo[1,2-c][1,3-2]oxaza; borole; BH3*THF / toluene / 5 - 20 °C
4: 70 percent / NaH / dimethylformamide / 3 h / 20 °C
5: 77 percent / NaH / dimethylformamide / 4 h / 5 - 20 °C
6: 96 percent / KOSiMe3 / tetrahydrofuran / 1 h / Heating
View Scheme
Multi-step reaction with 4 steps
1: 80 percent / i-Pr2NEt / tetrahydrofuran / 4 h
2: 76 percent / CaCl2*2H2O; NaBH4 / methanol / 2 h / 0 °C
3: 87 percent / sodium triacetoxyborohydride / CH2Cl2 / 18 h
4: 87 percent / H2 / aq. Pd(OH)2/C / ethanol / 18 h
View Scheme
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
102293-80-1

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

(5R)-5-(2,2-dimethyl- 4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one
452339-73-0

(5R)-5-(2,2-dimethyl- 4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 28 percent / Cs2CO3 / acetonitrile / 24 h / 21 °C
2: 43 percent / CF3CO2H / CH2Cl2 / 4 h / 20 °C
3: 99 percent / (R)-tetrahydro-1-Me-3,3-Ph2-1H,3H-pyrrolo[1,2-c][1,3-2]oxaza; borole; BH3*THF / toluene / 5 - 20 °C
4: 70 percent / NaH / dimethylformamide / 3 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: caesium carbonate / acetonitrile / 6 h / 20 - 25 °C / Inert atmosphere
2: trifluoroacetic acid / dichloromethane / 5 h / 10 - 25 °C
3: dimethylsulfide borane complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran; toluene / 1 h / -10 °C
4: potassium tert-butylate / N,N-dimethyl-formamide / 1 h / 10 - 20 °C
View Scheme
Multi-step reaction with 4 steps
1: caesium carbonate / acetonitrile / 20 °C
2: trifluoroacetic acid / dichloromethane / 2 h / 10 °C
3: (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; dimethylsulfide borane complex / toluene; tetrahydrofuran / 0.67 h / -10 °C / Inert atmosphere
4: potassium tert-butylate / N,N-dimethyl-formamide / 3 h / 0 - 20 °C / Inert atmosphere
View Scheme
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
102293-80-1

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

tert-butyl 2-(2,2-dimethyl-4H-1,3-benzodioxane-6-yl)-2-carbonylethylcarbamate
452339-71-8

tert-butyl 2-(2,2-dimethyl-4H-1,3-benzodioxane-6-yl)-2-carbonylethylcarbamate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 28 percent / Cs2CO3 / acetonitrile / 24 h / 21 °C
2: 43 percent / CF3CO2H / CH2Cl2 / 4 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: caesium carbonate / acetonitrile / 6 h / 20 - 25 °C / Inert atmosphere
2: trifluoroacetic acid / dichloromethane / 5 h / 10 - 25 °C
View Scheme
Multi-step reaction with 2 steps
1: caesium carbonate / acetonitrile / 20 °C
2: trifluoroacetic acid / dichloromethane / 2 h / 10 °C
View Scheme
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
102293-80-1

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

tert-butyl (2R)-2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-hydroxyethylcarbamate
452339-72-9

tert-butyl (2R)-2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-hydroxyethylcarbamate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 28 percent / Cs2CO3 / acetonitrile / 24 h / 21 °C
2: 43 percent / CF3CO2H / CH2Cl2 / 4 h / 20 °C
3: 99 percent / (R)-tetrahydro-1-Me-3,3-Ph2-1H,3H-pyrrolo[1,2-c][1,3-2]oxaza; borole; BH3*THF / toluene / 5 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1: caesium carbonate / acetonitrile / 6 h / 20 - 25 °C / Inert atmosphere
2: trifluoroacetic acid / dichloromethane / 5 h / 10 - 25 °C
3: dimethylsulfide borane complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran; toluene / 1 h / -10 °C
View Scheme
Multi-step reaction with 3 steps
1: caesium carbonate / acetonitrile / 20 °C
2: trifluoroacetic acid / dichloromethane / 2 h / 10 °C
3: (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; dimethylsulfide borane complex / toluene; tetrahydrofuran / 0.67 h / -10 °C / Inert atmosphere
View Scheme
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
102293-80-1

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

(5R)-5-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-3-[6-(4-phenylbutoxy)hexyl]-1,3-oxazolidin-2-one
590410-68-7

(5R)-5-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-3-[6-(4-phenylbutoxy)hexyl]-1,3-oxazolidin-2-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 28 percent / Cs2CO3 / acetonitrile / 24 h / 21 °C
2: 43 percent / CF3CO2H / CH2Cl2 / 4 h / 20 °C
3: 99 percent / (R)-tetrahydro-1-Me-3,3-Ph2-1H,3H-pyrrolo[1,2-c][1,3-2]oxaza; borole; BH3*THF / toluene / 5 - 20 °C
4: 70 percent / NaH / dimethylformamide / 3 h / 20 °C
5: 77 percent / NaH / dimethylformamide / 4 h / 5 - 20 °C
View Scheme
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
102293-80-1

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-[(1S)-2-methoxy-1-phenylethylamino]ethanol

1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-[(1S)-2-methoxy-1-phenylethylamino]ethanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 64 percent / polystyryldiisopropylethylamine / tetrahydrofuran / 2 h
2: 91 percent / CaCl2; polystyryl(trimethyl)ammonium borohydride / methanol / 2 h / 0 - 20 °C
View Scheme
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
102293-80-1

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

(1S)-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-[(1S)-2-hydroxy-1-phenylethylamino]ethanol

(1S)-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-[(1S)-2-hydroxy-1-phenylethylamino]ethanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 80 percent / i-Pr2NEt / tetrahydrofuran / 4 h
2: CaCl2*2H2O; NaBH4 / methanol / 2 h / 0 °C
View Scheme
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
102293-80-1

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

(1R,1'S)-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-2-(2-hydroxy-1-phenyl-ethylamino)-ethanol
380414-68-6

(1R,1'S)-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-2-(2-hydroxy-1-phenyl-ethylamino)-ethanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 80 percent / i-Pr2NEt / tetrahydrofuran / 4 h
2: 76 percent / CaCl2*2H2O; NaBH4 / methanol / 2 h / 0 °C
View Scheme
Multi-step reaction with 2 steps
1.1: resin-N(iPr)2 / tetrahydrofuran
2.1: CaCl2 / methanol / 0.17 h / 0 °C
2.2: 76 percent / resin-NMe3(1+)*BH4(1-) / methanol / 2 h / 0 - 20 °C
View Scheme
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
102293-80-1

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

(4S)-3-[2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-hydroxyethyl]-4-phenyl-1,3-oxazolidin-2-one

(4S)-3-[2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-hydroxyethyl]-4-phenyl-1,3-oxazolidin-2-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 80 percent / i-Pr2NEt / tetrahydrofuran / 4 h
2: 91 percent / CH2Cl2 / 0.25 h
3: 87 percent / CaCl2; polystyryl(trimethyl)ammonium borohydride / methanol / 2 h / 0 - 20 °C
View Scheme
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
102293-80-1

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

(4S)-3-[2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-oxoethyl]-4-phenyl-1,3-oxazolidin-2-one
500317-72-6

(4S)-3-[2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-oxoethyl]-4-phenyl-1,3-oxazolidin-2-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 80 percent / i-Pr2NEt / tetrahydrofuran / 4 h
2: 91 percent / CH2Cl2 / 0.25 h
View Scheme
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
102293-80-1

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

(1R,1'S)-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-2-{(2-hydroxy-1-phenyl-ethyl)-[6-(4-phenyl-butoxy)-hexyl]-amino}-ethanol
380414-69-7

(1R,1'S)-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-2-{(2-hydroxy-1-phenyl-ethyl)-[6-(4-phenyl-butoxy)-hexyl]-amino}-ethanol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 80 percent / i-Pr2NEt / tetrahydrofuran / 4 h
2: 76 percent / CaCl2*2H2O; NaBH4 / methanol / 2 h / 0 °C
3: 87 percent / sodium triacetoxyborohydride / CH2Cl2 / 18 h
View Scheme
Multi-step reaction with 3 steps
1.1: resin-N(iPr)2 / tetrahydrofuran
2.1: CaCl2 / methanol / 0.17 h / 0 °C
2.2: 76 percent / resin-NMe3(1+)*BH4(1-) / methanol / 2 h / 0 - 20 °C
3.1: (polystyrylmethyl)trimethylammonium cyanoborohydride; AcOH / CH2Cl2
3.2: 98 percent / resin-NMe3(1+)*NaCO3(1-) / CH2Cl2
View Scheme
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
102293-80-1

2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone

2-{bis-[6-(4-phenyl-butoxy)-hexyl]-amino}-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-ethanol

2-{bis-[6-(4-phenyl-butoxy)-hexyl]-amino}-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-ethanol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: resin-N(iPr)2 / tetrahydrofuran
2.1: CaCl2 / methanol / 0.17 h / 0 °C
2.2: 76 percent / resin-NMe3(1+)*BH4(1-) / methanol / 2 h / 0 - 20 °C
3.1: H2 / Pd(OH)2/C / ethyl acetate
View Scheme

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