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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

2-Aminoethylmethylsulfone hydrochloride Manufacturer/High quality/Best price/In stock

Cas:104458-24-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2-Aminoethylmethylsulfonehydrochloride supplier in China

Cas:104458-24-4

Min.Order:1 Metric Ton

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance White to pale yellow powder White powder Assay, wt% ≥98.

High purity Various Specifications 2-Aminoethylmethylsulfone hydrochloride CAS:104458-24-4

Cas:104458-24-4

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

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Kono Chem Co.,Ltd

QuickDetails Type:HerbalExtract,plantextract Variety:soybeanoligosaccharide Form:Powder Part:Leaf …Appearance:Solid Storage:Preserve in tightly sealed,light and oxygen resistant containers Package:D

2-Aminoethylmethylsulfone hydrochloride

Cas:104458-24-4

Min.Order:1 Kilogram

FOB Price: $20.0

Type:Other

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Jinan Finer Chemical Co., Ltd

Product description: Product name 2-Aminoethylmethylsulfone hydrochloride CAS number 104458-24-4 Assay ≥99% Appearance Off-white to yellowish powder Capacity 100mt/year Applicat

2-Aminoethylmethylsulfone hydrochloride

Cas:104458-24-4

Min.Order:100 Gram

FOB Price: $12.0

Type:Lab/Research institutions

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Hangzhou Think Chemical Co. Ltd

Lapatinib Intermediates 4-Chloro-6-iodoquinazoline[CAS:98556-31-1] 2-(Methylsulfonyl)ethylamine Hydrochloride[CAS:104458-24-4] Molecular Formula C3H9NO2S.HCl Molecular Weight 1

Manufacture 2-(Methylsulfonyl)ethylamine Hydrochloride

Cas:104458-24-4

Min.Order:1 Kilogram

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Type:Other

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 2-(methanesulfonyl)ethylamine hydrochloride

Cas:104458-24-4

Min.Order:1

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Type:Other

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ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price. 1.Quick response within 24 hours. 2.Best quality in your requirement. 3.We pay more attention on delivery time, and usually ship on time. 4.Free samples will be provided. 5.Ensure specifications an

2-Aminoethylmethylsulfone hydrochloride

Cas:104458-24-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Hebei yanxi chemical co.,LTD.

Our advantage: 1: High quality and Competitive price 2: Quality control, GC&HPLC&NMR or as your requested 3: Packing as your requested, and double check before shipment 4: Prompt shipment with professional documents 5: Excellent after-

2-Aminoethylmethylsulfone Hydrochloride CAS NO.104458-24-4

Cas:104458-24-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 3.0

Type:Trading Company

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-(Methylsulfonyl)-ethanamine hydrochloride

Cas:104458-24-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM-- 104458-24-4 -- 2-Aminoethylmethylsulfone hydrochloride in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established s

TIANFUCHEM-- 104458-24-4 -- 2-Aminoethylmethylsulfone hydrochloride in stock

Cas:104458-24-4

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

2-Aminoethylmethylsulfone hydrochloride

Cas:104458-24-4

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be

2-Aminoethylmethylsulfone Hydrochloride cas 104458-24-4

Cas:104458-24-4

Min.Order:1 Gram

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Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 104458-24-4 with competitive price

Cas:104458-24-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

2-(Methylsulfonyl)-ethanaMine hydrochloride

Cas:104458-24-4

Min.Order:10 Kilogram

FOB Price: $180.0 / 200.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product name 2-Aminoethylmethylsulfone hydrochloride CAS 104458-24-4 Molecular Formula C3H10ClNO2S Molecular Weight 159.63 Me

2-Aminoethylmethylsulfone hydrochloride

Cas:104458-24-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:powder Storage:Store in sealed containers at cool & dry pla

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Ethanamine,2-(methylsulfonyl)-, hydrochloride (1:1) 104458-24-4

Cas:104458-24-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Animal Pharmaceuticals, 2-Aminoethylmethylsulfone hydrochloride CAS:104458-24-4

Cas:104458-24-4

Min.Order:1 Gram

FOB Price: $4.0 / 5.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

2-Aminoethylmethylsulfone hydrochloride CAS:104458-24-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high

2-Aminoethylmethylsulfone hydrochloride CAS:104458-24-4

Cas:104458-24-4

Min.Order:1 Gram

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Ethanamine,2-(methylsulfonyl)-, hydrochloride (1:1)

Cas:104458-24-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Changchun Artel lmport and Export trade company

best price,best quality and fast delivery assurance available in sample product and customization with years of export experience along with excellent quality, advanced services and competitive prices the quality of products conform u

2-Aminoethylmethylsulfone hydrochloride CAS NO.104458-24-4

Cas:104458-24-4

Min.Order:10 Gram

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Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:104458-24-4

Cas:104458-24-4

Min.Order:0

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Lonwin Chemical Group Limited

2-Aminoethylmethylsulfone hydrochloride CAS: 104458-24-4 Specification Product Name Soybean oligosaccharides Brand Name PB Latin Name Lycopus lucidus Turuz CAS 10094-58-3 Molecular formula C24H42O2

Factory supply 2-Aminoethylmethylsulfone hydrochloride

Cas:104458-24-4

Min.Order:1 Kilogram

Negotiable

Type:Other

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2-Aminoethylmethylsulfone Hydrochloride

Cas:104458-24-4

Min.Order:0

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Type:Manufacturers

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Hangzhou Maytime Bio-Tech Co.,Ltd.

We have one R&D laboratory and two product bases in Hangzhou which are established as per GMP requirements. Our technical force is rich and has a passel of technologists who have engaged in research and production of medication for

CAS NO.104458-24-4 2-Aminoethylmethylsulfone hydrochloride

Cas:104458-24-4

Min.Order:1 Kilogram

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Type:Other

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Specification:USP/EP Month production ablity:50kg/Month Low price& High quality Manufacturer Appearance:white powder Storage:Room Temperature Application:104458-24-4

Lapatinib intermediate 104458-24-4

Cas:104458-24-4

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

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Triumph International Development Limilted

Appearance:off-white to white solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:As customer request Port:Qingda

Ethanamine,2-(methylsulfonyl)-, hydrochloride (1:1) 104458-24-4

Cas:104458-24-4

Min.Order:1 Kilogram

FOB Price: $10.0

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

2-Aminoethylmethylsulfone hydrochloride

Cas:104458-24-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

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Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

2-Aminoethylmethylsulfone hydrochloride 104458-24-4

Cas:104458-24-4

Min.Order:100 Gram

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Synthetic route

tert-butyl 2-(methylsulfonyl)ethylcarbamate
154095-06-4

tert-butyl 2-(methylsulfonyl)ethylcarbamate

2-(methylsulfonyl)ethylamine hydrochloride
104458-24-4

2-(methylsulfonyl)ethylamine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethyl acetate at 0 - 20℃;97%
With hydrogenchloride In ethanol at 20℃; Temperature;88%
With hydrogenchloride In diethyl ether; ethyl acetate at 20℃;78%
(2-aminoethyl)methylsulfide
18542-42-2

(2-aminoethyl)methylsulfide

2-(methylsulfonyl)ethylamine hydrochloride
104458-24-4

2-(methylsulfonyl)ethylamine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; dihydrogen peroxide In water at 25 - 30℃; pH=3 - 4; Solvent;94.8%
2-<2-(methylsulfonyl)ethyl>-1H-isoindole-1,3(2H)dione

2-<2-(methylsulfonyl)ethyl>-1H-isoindole-1,3(2H)dione

2-(methylsulfonyl)ethylamine hydrochloride
104458-24-4

2-(methylsulfonyl)ethylamine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; water at 100℃; for 10h; Reagent/catalyst; Temperature;92.1%
With hydrogenchloride In water at 100℃; for 10h;92.1%
hydrochloride of methyl-<β-amino-ethyl>-sulfide

hydrochloride of methyl-<β-amino-ethyl>-sulfide

2-(methylsulfonyl)ethylamine hydrochloride
104458-24-4

2-(methylsulfonyl)ethylamine hydrochloride

Conditions
ConditionsYield
With potassium permanganate; water
2-Methanesulfonyl-ethylamine
49773-20-8

2-Methanesulfonyl-ethylamine

2-(methylsulfonyl)ethylamine hydrochloride
104458-24-4

2-(methylsulfonyl)ethylamine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethanol Product distribution / selectivity;
2-(methylsulfonyl)ethylamine hydrochloride
104458-24-4

2-(methylsulfonyl)ethylamine hydrochloride

5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde
231278-84-5

5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde

lapatanib
231277-92-2

lapatanib

Conditions
ConditionsYield
Stage #1: 2-(methylsulfonyl)ethylamine hydrochloride With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 0.333333h;
Stage #2: 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde With acetic acid In tetrahydrofuran at 40℃; for 2h;
Stage #3: With sodium tris(acetoxy)borohydride In tetrahydrofuran at 25 - 40℃; for 3h; Concentration;
100%
Stage #1: 2-(methylsulfonyl)ethylamine hydrochloride; 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 50 - 60℃; for 4h;
Stage #2: With sodium cyanoborohydride In isopropyl alcohol at 20℃; for 2h;
92.6%
Stage #1: 2-(methylsulfonyl)ethylamine hydrochloride With sodium sulfate; triethylamine In methanol at 0℃; for 0.333333h;
Stage #2: 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde With formic acid; sodium cyanoborohydride In tetrahydrofuran; methanol; N,N-dimethyl-formamide for 2h; pH=5 - 6;
82%
5-(4-(3-chloro-4-hydroxyphenylamino)quinazolin-6-yl)furan-2-carbaldehyde tosylate
1440511-82-9

5-(4-(3-chloro-4-hydroxyphenylamino)quinazolin-6-yl)furan-2-carbaldehyde tosylate

2-(methylsulfonyl)ethylamine hydrochloride
104458-24-4

2-(methylsulfonyl)ethylamine hydrochloride

2-chloro-4-(6-(5-((2-(methylsulfonyl)ethylimino)methyl)furan-2-yl)quinazolin-4-ylamino)phenol
1440511-83-0

2-chloro-4-(6-(5-((2-(methylsulfonyl)ethylimino)methyl)furan-2-yl)quinazolin-4-ylamino)phenol

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In methanol at 20 - 25℃; for 20h;97.1%
C27H19ClFN3O3

C27H19ClFN3O3

2-(methylsulfonyl)ethylamine hydrochloride
104458-24-4

2-(methylsulfonyl)ethylamine hydrochloride

lapatanib
231277-92-2

lapatanib

Conditions
ConditionsYield
With triethylamine In dichloromethane at 25 - 30℃; Inert atmosphere;97%
2-(methylsulfonyl)ethylamine hydrochloride
104458-24-4

2-(methylsulfonyl)ethylamine hydrochloride

5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde
231278-84-5

5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde

N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(5-((2-(methylsulfonyl)ethylimino)methyl)furan-2-yl)quinazolin-4-amine
1227853-06-6

N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(5-((2-(methylsulfonyl)ethylimino)methyl)furan-2-yl)quinazolin-4-amine

Conditions
ConditionsYield
With triethylamine In methanol for 12h; Reflux;96%
With triethylamine In methanol for 12h; Reflux;96%
With triethylamine In methanol for 12h; Reflux;
2-(methylsulfonyl)ethylamine hydrochloride
104458-24-4

2-(methylsulfonyl)ethylamine hydrochloride

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde
231278-84-5

5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde

lapatinib ditosylate
388082-78-8

lapatinib ditosylate

Conditions
ConditionsYield
Stage #1: 2-(methylsulfonyl)ethylamine hydrochloride; 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde With tetrabutylammomium bromide; triethylamine In tetrahydrofuran at 30℃; for 3h;
Stage #2: With sodium tris(acetoxy)borohydride In tetrahydrofuran at 20℃; for 4h;
Stage #3: toluene-4-sulfonic acid In tetrahydrofuran at 50℃; for 1h;
94.9%
Stage #1: 2-(methylsulfonyl)ethylamine hydrochloride; 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde With acetic acid; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 3h;
Stage #2: With sodium tris(acetoxy)borohydride In tetrahydrofuran at 20℃; for 12h;
Stage #3: toluene-4-sulfonic acid In tetrahydrofuran at 20℃; for 12h;
82.8%
Stage #1: 2-(methylsulfonyl)ethylamine hydrochloride; 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde With acetic acid; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; N,N-dimethyl-formamide at 35℃; for 1h;
Stage #2: With sodium tris(acetoxy)borohydride In tetrahydrofuran; N,N-dimethyl-formamide at 20 - 25℃; for 2h;
Stage #3: toluene-4-sulfonic acid
72%
Stage #1: 2-(methylsulfonyl)ethylamine hydrochloride; 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; acetic acid at 30 - 35℃; for 1h;
Stage #2: With sodium tris(acetoxy)borohydride In tetrahydrofuran; acetic acid at 22℃; for 2 - 4h;
Stage #3: toluene-4-sulfonic acid With sodium hydroxide In tetrahydrofuran; acetic acid
5-bromo-2-furancarboxaldehyde
1899-24-7

5-bromo-2-furancarboxaldehyde

2-(methylsulfonyl)ethylamine hydrochloride
104458-24-4

2-(methylsulfonyl)ethylamine hydrochloride

(E)-N-((5-bromofuran-2-yl)methylene)-2-(methylsulfonyl)ethylamine

(E)-N-((5-bromofuran-2-yl)methylene)-2-(methylsulfonyl)ethylamine

Conditions
ConditionsYield
Stage #1: 5-bromo-2-furancarboxaldehyde; 2-(methylsulfonyl)ethylamine hydrochloride With magnesium sulfate In dichloromethane at -5℃; for 2h; Inert atmosphere;
Stage #2: With triethylamine In dichloromethane at -5℃; for 2h; Inert atmosphere;
94.25%
3-(3-(4-chloro-5-fluoropyrimidin-2-yl)-1-(2-fluorobenzyl)-1H-pyrazol-5-yl)isoxazole
1446358-48-0

3-(3-(4-chloro-5-fluoropyrimidin-2-yl)-1-(2-fluorobenzyl)-1H-pyrazol-5-yl)isoxazole

2-(methylsulfonyl)ethylamine hydrochloride
104458-24-4

2-(methylsulfonyl)ethylamine hydrochloride

C20H18F2N6O3S

C20H18F2N6O3S

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane; water at 100℃; for 17h;91%
formaldehyd
50-00-0

formaldehyd

6-(furan-2-yl)-4-[3-chloro-4-(3-fluorobenzyloxy)phenyl]aminoquinazoline

6-(furan-2-yl)-4-[3-chloro-4-(3-fluorobenzyloxy)phenyl]aminoquinazoline

2-(methylsulfonyl)ethylamine hydrochloride
104458-24-4

2-(methylsulfonyl)ethylamine hydrochloride

lapatanib
231277-92-2

lapatanib

Conditions
ConditionsYield
In tetrahydrofuran at 35 - 40℃; for 4h;90.3%
2-(methylsulfonyl)ethylamine hydrochloride
104458-24-4

2-(methylsulfonyl)ethylamine hydrochloride

D-arabinono-1,4-lactone 5-(dihydrogenophosphate)
219946-62-0

D-arabinono-1,4-lactone 5-(dihydrogenophosphate)

N-(5-phosphate-D-arabinoyl)-2-(methylsulfonyl)ethanamine

N-(5-phosphate-D-arabinoyl)-2-(methylsulfonyl)ethanamine

Conditions
ConditionsYield
Stage #1: 2-(methylsulfonyl)ethylamine hydrochloride With sodium methylate at 35℃; Inert atmosphere;
Stage #2: D-arabinono-1,4-lactone 5-(dihydrogenophosphate) With methanol at 20℃; for 1.5h; Inert atmosphere;
89%
ethyl 4-chloro-3-nitrobenzoate
16588-16-2

ethyl 4-chloro-3-nitrobenzoate

2-(methylsulfonyl)ethylamine hydrochloride
104458-24-4

2-(methylsulfonyl)ethylamine hydrochloride

ethyl 4-((2-(methylsulfonyl)ethyl)amino)-3-nitrobenzoate

ethyl 4-((2-(methylsulfonyl)ethyl)amino)-3-nitrobenzoate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 60℃; for 16h;89%
2-(methylsulfonyl)ethylamine hydrochloride
104458-24-4

2-(methylsulfonyl)ethylamine hydrochloride

(±)-gossypol acetic acid
5453-04-3, 866541-93-7, 1189561-66-7

(±)-gossypol acetic acid

C36H44N2O10S2

C36H44N2O10S2

Conditions
ConditionsYield
Stage #1: 2-(methylsulfonyl)ethylamine hydrochloride With sodium hydroxide In ethanol for 1h; Reflux;
Stage #2: (±)-gossypol acetic acid In ethanol for 5h; Reflux;
86.8%
4-((E)-{[1-(3-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]hydrazono}methyl)benzoic acid
650626-22-5

4-((E)-{[1-(3-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]hydrazono}methyl)benzoic acid

2-(methylsulfonyl)ethylamine hydrochloride
104458-24-4

2-(methylsulfonyl)ethylamine hydrochloride

4-((E)-{[1-(3-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]hydrazono}methyl)-N-[2-(methylsulfonyl)ethyl]benzamide

4-((E)-{[1-(3-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]hydrazono}methyl)-N-[2-(methylsulfonyl)ethyl]benzamide

Conditions
ConditionsYield
With diethyl cyanophosphonate; triethylamine In DMF (N,N-dimethyl-formamide) at 20℃; for 16h;84%
2-(methylsulfonyl)ethylamine hydrochloride
104458-24-4

2-(methylsulfonyl)ethylamine hydrochloride

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde
231278-84-5

5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde

N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulphonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine bis(4-methylbenzenesulphonate) monohydrate

N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulphonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine bis(4-methylbenzenesulphonate) monohydrate

Conditions
ConditionsYield
Stage #1: 2-(methylsulfonyl)ethylamine hydrochloride; 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde With acetic acid; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 3h;
Stage #2: With sodium tris(acetoxy)borohydride In tetrahydrofuran at 20℃; for 12h;
Stage #3: toluene-4-sulfonic acid With water In tetrahydrofuran at 20℃; for 12h;
82.8%
2-amino-5-[(5-formyl)furan-2-yl]benzonitrile p-toluenesulfonic acid

2-amino-5-[(5-formyl)furan-2-yl]benzonitrile p-toluenesulfonic acid

2-(methylsulfonyl)ethylamine hydrochloride
104458-24-4

2-(methylsulfonyl)ethylamine hydrochloride

2-amino-5-[5-[[[2-(methanesulfonyl)ethyl]amino]methyl]furan-2-yl]benzonitrile

2-amino-5-[5-[[[2-(methanesulfonyl)ethyl]amino]methyl]furan-2-yl]benzonitrile

Conditions
ConditionsYield
Stage #1: 2-amino-5-[(5-formyl)furan-2-yl]benzonitrile p-toluenesulfonic acid; 2-(methylsulfonyl)ethylamine hydrochloride With acetic acid; triethylamine In tetrahydrofuran at 20 - 35℃; for 1h;
Stage #2: With sodium tris(acetoxy)borohydride In tetrahydrofuran at 22 - 25℃; for 2.5h;
82.7%
4-(4-(E)-(propen-1-yl)phenylamino)-6-(5-formylfuran-2-yl)quinazoline

4-(4-(E)-(propen-1-yl)phenylamino)-6-(5-formylfuran-2-yl)quinazoline

2-(methylsulfonyl)ethylamine hydrochloride
104458-24-4

2-(methylsulfonyl)ethylamine hydrochloride

4-(4-(E)-(propen-1-yl)phenylamino)-6-(5-((2-(methylsulfonyl)ethyl)aminomethyl)furan-2-yl)quinazoline

4-(4-(E)-(propen-1-yl)phenylamino)-6-(5-((2-(methylsulfonyl)ethyl)aminomethyl)furan-2-yl)quinazoline

Conditions
ConditionsYield
Stage #1: 2-(methylsulfonyl)ethylamine hydrochloride With sodium sulfate; triethylamine In methanol at 0℃; for 0.333333h;
Stage #2: 4-(4-(E)-(propen-1-yl)phenylamino)-6-(5-formylfuran-2-yl)quinazoline With formic acid; sodium cyanoborohydride In tetrahydrofuran; methanol; N,N-dimethyl-formamide for 2h; pH=5 - 6;
82.6%
4-((E)-{[1-(6-methoxypyridin-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]hydrazono}methyl)benzoic acid
650637-47-1

4-((E)-{[1-(6-methoxypyridin-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]hydrazono}methyl)benzoic acid

2-(methylsulfonyl)ethylamine hydrochloride
104458-24-4

2-(methylsulfonyl)ethylamine hydrochloride

4-((E)-{[1-(6-methoxypyridin-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]hydrazono}methyl)-N-[2-(methylsulfonyl)ethyl]benzamide

4-((E)-{[1-(6-methoxypyridin-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]hydrazono}methyl)-N-[2-(methylsulfonyl)ethyl]benzamide

Conditions
ConditionsYield
With diethyl cyanophosphonate; triethylamine In DMF (N,N-dimethyl-formamide) at 20℃; for 16h;81%
4-((E)-{[1-(2-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]hydrazono}methyl)benzoic acid

4-((E)-{[1-(2-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]hydrazono}methyl)benzoic acid

2-(methylsulfonyl)ethylamine hydrochloride
104458-24-4

2-(methylsulfonyl)ethylamine hydrochloride

4-((E)-{[1-(2-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]hydrazono}methyl)-N-[2-(methylsulfonyl)ethyl]benzamide hydrochloride

4-((E)-{[1-(2-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]hydrazono}methyl)-N-[2-(methylsulfonyl)ethyl]benzamide hydrochloride

Conditions
ConditionsYield
Stage #1: 4-((E)-{[1-(2-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]hydrazono}methyl)benzoic acid; 2-(methylsulfonyl)ethylamine hydrochloride With diethyl cyanophosphonate; triethylamine In DMF (N,N-dimethyl-formamide) at 20℃; for 16h;
Stage #2: With hydrogenchloride In water
81%
2-(methylsulfonyl)ethylamine hydrochloride
104458-24-4

2-(methylsulfonyl)ethylamine hydrochloride

4-((E)-{[1-(3-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]hydrazono}methyl)benzoic acid
650627-05-7

4-((E)-{[1-(3-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]hydrazono}methyl)benzoic acid

4-((E)-{[1-(3-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]hydrazono}methyl)-N-[2-(methylsulfonyl)ethyl]benzamide

4-((E)-{[1-(3-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]hydrazono}methyl)-N-[2-(methylsulfonyl)ethyl]benzamide

Conditions
ConditionsYield
With diethyl cyanophosphonate; triethylamine In DMF (N,N-dimethyl-formamide) at 20℃; for 16h;81%
4-((E)-{[1-(3-nitrophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]hydrazono}methyl)benzoic acid
650626-44-1

4-((E)-{[1-(3-nitrophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]hydrazono}methyl)benzoic acid

2-(methylsulfonyl)ethylamine hydrochloride
104458-24-4

2-(methylsulfonyl)ethylamine hydrochloride

N-[2-(methylsulfonyl)ethyl]-4-((E)-{[1-(3-nitrophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]hydrazono}methyl)benzamide

N-[2-(methylsulfonyl)ethyl]-4-((E)-{[1-(3-nitrophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]hydrazono}methyl)benzamide

Conditions
ConditionsYield
With diethyl cyanophosphonate; triethylamine In DMF (N,N-dimethyl-formamide) at 20℃; for 16h;80%
2-(methylsulfonyl)ethylamine hydrochloride
104458-24-4

2-(methylsulfonyl)ethylamine hydrochloride

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulphonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine bis(4-methylbenzenesulphonate) monohydrate

N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulphonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine bis(4-methylbenzenesulphonate) monohydrate

Conditions
ConditionsYield
Stage #1: 5-(4-[3-chloro-4-(3-fluorobenzyloxy)-anilino]-6-quinazolinyl)-furan-2-carbaldehyde 4-methylbenzenesulfonate; 2-(methylsulfonyl)ethylamine hydrochloride With acetic acid; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 30 - 35℃; for 1h;
Stage #2: With sodium tris(acetoxy)borohydride In tetrahydrofuran at 22℃; for 2h;
Stage #3: toluene-4-sulfonic acid With sodium hydroxide; water more than 3 stages;
80%
5-[4-(tetrahydro-2H-pyran-2-yloxy)quinazolin-6-yl]furan-2-carbaldehyde
1383531-70-1

5-[4-(tetrahydro-2H-pyran-2-yloxy)quinazolin-6-yl]furan-2-carbaldehyde

2-(methylsulfonyl)ethylamine hydrochloride
104458-24-4

2-(methylsulfonyl)ethylamine hydrochloride

2-(methylsulphonyl)-N-({5-[4-(tetrahydro-2H-pyran-2-yloxy)quinazolin-6-yl]furan-2-yl}methyl)ethanamine
1383531-71-2

2-(methylsulphonyl)-N-({5-[4-(tetrahydro-2H-pyran-2-yloxy)quinazolin-6-yl]furan-2-yl}methyl)ethanamine

Conditions
ConditionsYield
Stage #1: 5-[4-(tetrahydro-2H-pyran-2-yloxy)quinazolin-6-yl]furan-2-carbaldheyde; 2-(methylsulfonyl)ethylamine hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 20 - 35℃; for 0.5h; Inert atmosphere;
Stage #2: With sodium tris(acetoxy)borohydride In dichloromethane at 20 - 25℃; for 2h;
Stage #3: With sodium hydrogencarbonate In dichloromethane
80%
Stage #1: 5-[4-(tetrahydro-2H-pyran-2-yloxy)quinazolin-6-yl]furan-2-carbaldheyde; 2-(methylsulfonyl)ethylamine hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 30 - 35℃; for 0.5h; Inert atmosphere;
Stage #2: With sodium tris(acetoxy)borohydride In dichloromethane at 20 - 25℃; for 2h;
80%
Stage #1: 5-[4-(tetrahydro-2H-pyran-2-yloxy)quinazolin-6-yl]furan-2-carbaldheyde; 2-(methylsulfonyl)ethylamine hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 20 - 35℃; for 0.5h; Inert atmosphere;
Stage #2: With sodium tris(acetoxy)borohydride In dichloromethane at 20 - 25℃; for 2h; Inert atmosphere;
80%
4-(3-ethynyl-phenylamino)-6-(5-formylfuran-2-yl)quinazoline

4-(3-ethynyl-phenylamino)-6-(5-formylfuran-2-yl)quinazoline

2-(methylsulfonyl)ethylamine hydrochloride
104458-24-4

2-(methylsulfonyl)ethylamine hydrochloride

4-(3-ethynylphenylamino)-6-(5-((2-(methylsulfonyl)ethyl)aminomethyl)furan-2-yl)quinazoline

4-(3-ethynylphenylamino)-6-(5-((2-(methylsulfonyl)ethyl)aminomethyl)furan-2-yl)quinazoline

Conditions
ConditionsYield
Stage #1: 2-(methylsulfonyl)ethylamine hydrochloride With sodium sulfate; triethylamine In methanol at 0℃; for 0.333333h;
Stage #2: 4-(3-ethynyl-phenylamino)-6-(5-formylfuran-2-yl)quinazoline With formic acid; sodium cyanoborohydride In tetrahydrofuran; methanol; N,N-dimethyl-formamide for 2h; pH=5 - 6;
79.7%
4-(3-chloro-4-fluorophenylamino)-6-(5-formylfuran-2-yl)quinazoline
1421356-86-6

4-(3-chloro-4-fluorophenylamino)-6-(5-formylfuran-2-yl)quinazoline

2-(methylsulfonyl)ethylamine hydrochloride
104458-24-4

2-(methylsulfonyl)ethylamine hydrochloride

4-(3-chloro-4-fluorophenylamino)-6-(5-((2-(methylsulfonyl)ethyl)aminomethyl)furan-2-yl)quinazoline

4-(3-chloro-4-fluorophenylamino)-6-(5-((2-(methylsulfonyl)ethyl)aminomethyl)furan-2-yl)quinazoline

Conditions
ConditionsYield
Stage #1: 2-(methylsulfonyl)ethylamine hydrochloride With sodium sulfate; triethylamine In methanol at 0℃; for 0.333333h;
Stage #2: N-(3-chloro-4-fluorophenyl)-6-(5-formyl-2-furyl)-4-quinazolinamine With formic acid; sodium cyanoborohydride In tetrahydrofuran; methanol; N,N-dimethyl-formamide for 2h; pH=5 - 6;
78.1%
2-(methylsulfonyl)ethylamine hydrochloride
104458-24-4

2-(methylsulfonyl)ethylamine hydrochloride

trifluoroacetic acid
76-05-1

trifluoroacetic acid

(2-methanesulfonyl-ethyl)-(6-methyl-5-nitro-pyridin-2-yl)-amine trifluoroacetate
897732-57-9

(2-methanesulfonyl-ethyl)-(6-methyl-5-nitro-pyridin-2-yl)-amine trifluoroacetate

Conditions
ConditionsYield
Stage #1: 6-fluoro-2-methyl-3-nitro-pyridine; 2-(methylsulfonyl)ethylamine hydrochloride With potassium carbonate In tetrahydrofuran at 20 - 60℃; for 100h;
Stage #2: trifluoroacetic acid
78%
(S)-4-(4-((2-hydroxy-1-phenylethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-3-methoxybenzaldehyde
1637438-04-0

(S)-4-(4-((2-hydroxy-1-phenylethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-3-methoxybenzaldehyde

2-(methylsulfonyl)ethylamine hydrochloride
104458-24-4

2-(methylsulfonyl)ethylamine hydrochloride

(S)-2-((6-(2-methoxy-4-(((2-(methylsulfonyl)ethyl)amino)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-phenylethan-1-ol

(S)-2-((6-(2-methoxy-4-(((2-(methylsulfonyl)ethyl)amino)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-phenylethan-1-ol

Conditions
ConditionsYield
Stage #1: 2-(methylsulfonyl)ethylamine hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.5h;
Stage #2: (S)-4-(4-((2-hydroxy-1-phenylethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-3-methoxybenzaldehyde In dichloromethane at 20℃; for 6h;
Stage #3: With sodium tetrahydroborate In methanol for 3h;
77%
4-((E)-{[1-(4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]hydrazono}methyl)benzoic acid
650626-61-2

4-((E)-{[1-(4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]hydrazono}methyl)benzoic acid

2-(methylsulfonyl)ethylamine hydrochloride
104458-24-4

2-(methylsulfonyl)ethylamine hydrochloride

4-((E)-{[1-(4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]hydrazono}methyl)-N-[2-(methylsulfonyl)ethyl]benzamide

4-((E)-{[1-(4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]hydrazono}methyl)-N-[2-(methylsulfonyl)ethyl]benzamide

Conditions
ConditionsYield
With diethyl cyanophosphonate; triethylamine In DMF (N,N-dimethyl-formamide) at 20℃; for 16h;76%

Raw Materials

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