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HANWAYS CHEMPHARM CO.,LIMITED

We are concentrating on APIs and pharmaceutical intermediates. With in depth knowledge and understanding in this industry, we are indulged in supplying a wide assortments of lapatinib from Wuhan, Hubei, China. It is ma

lapatinib

Cas:231277-92-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Trading Company

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DALIAN BAIJIA IMPORT AND EXPORT CO., LTD

Dalian Bajia import and export co. ltd have great engineer make more great quality cargo will meet all customer request . Now we have own lab for cargo even my cargo is so less but quality and quantity and shippment will be promise as we are pro

LAPATINIB

Cas:231277-92-2

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Lapatinib Manufacturer/High quality/Best price/In stock

Cas:231277-92-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Lapatinib supplier in China

Cas:231277-92-2

Min.Order:0 Metric Ton

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Kono Chem Co.,Ltd

Lapatinib Manufacturer CAS No.231277-92-2 Product Name: Lapatinib Synonyms: N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine; 4-Quinazolinam

CAS:231277-92-2 Lapatinib factory sales

Cas:231277-92-2

Min.Order:1 Kilogram

Negotiable

Type:Other

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Hubei Vanz Pharm Co.,Ltd

Hubei Vanz Pharm Co., is the leading manufacture of APIs, supplements raw powder and some customization products. located in Wuhan, Hubei province. We are one of the most professional company in pharm/chemical industry for more than 10 years. We e

Lapatinib 231277-92-2

Cas:231277-92-2

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Name Lapatinib Synonyms N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine Molecular Structu

Lapatinib best price

Cas:231277-92-2

Min.Order:1 Gram

FOB Price: $1.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

Hebei yanxi chemical co., LTD is a professional research, development and production 2-phenylacetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low carbon environ

Lapatinib CAS NO.231277-92-2

Cas:231277-92-2

Min.Order:100 Gram

FOB Price: $2.0

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:cool dry place Package:1g/foil bag Application:medicine raw material Transportation:by courie

Manufacturer high quality Lapatinib Cas 231277-92-2 with good price

Cas:231277-92-2

Min.Order:1 Gram

Negotiable

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

Name Lapatinib Synonyms N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine Molecular Formul

Good quality Laparinib or Lapatinib Ditosylate stock

Cas:231277-92-2

Min.Order:100 Gram

Negotiable

Type:Other

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Lapatinib

Cas:231277-92-2

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Lapatinib 231277-92-2 ISO Producer

Cas:231277-92-2

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Lapatinib

Cas:231277-92-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

CHemwill -- Lapatinib

Cas:231277-92-2

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:Lapatinib CAS NO: 231277-92-2 Molecular formula:C29H26ClFN4O4S Molecular weight:581.0575 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability

Lapatinib/CAS:231277-92-2/Raw material supply

Cas:231277-92-2

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--231277-92-2-- Lapatinib in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business relationships

TIANFUCHEM--231277-92-2-- Lapatinib in stock

Cas:231277-92-2

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be

GMP High Purity Lapatinib CAS 231277-92-2

Cas:231277-92-2

Min.Order:1 Kilogram

FOB Price: $20.0 / 80.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 231277-92-2 with competitive price

Cas:231277-92-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Lapatinib

Cas:231277-92-2

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Lapatinib/ LIDE PHARMA- Factory supply / Best price

Cas:231277-92-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

[English Name] Lapatinib [Test Method]HPLC [CAS No.] 231277-92-2 [Mol. Formula]C29H26ClFN4O4S [Purity]> 99% by HPLC [Packaging]1KG,25KG/DRUM... Package and quantity according to customer's detail requirement [Remark] In stock,

Lapatinib 231277-92-2

Cas:231277-92-2

Min.Order:25 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Lapatinib 231277-92-2

Cas:231277-92-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

100% Safe Customs Clearance Fast Delivery Lapatinib Raw White Powder 100% Safe Customs Clearance

Cas:231277-92-2

Min.Order:10 Gram

FOB Price: $3.5

Type:Trading Company

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

An antineoplastic agent Lapatinib/CAS:231277-92-2

Cas:231277-92-2

Min.Order:5 Gram

FOB Price: $31.0 / 47.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Lapatinib CAS: 231277-92-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

Lapatinib CAS: 231277-92-2

Cas:231277-92-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Lapatinib

Cas:231277-92-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Superiority We can customize and synthesize products that other suppliers may not be able to provide. Advantage cof, mof ligand manufacturer Product Detail bes

Low price 99% Lapatinib CAS:231277-92-2

Cas:231277-92-2

Min.Order:100 Kilogram

Negotiable

Type:Trading Company

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Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

Lapatinib CAS231277-92-2

Cas:231277-92-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:231277-92-2

Cas:231277-92-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Synthetic route

2-(methylsulfonyl)ethylamine hydrochloride
104458-24-4

2-(methylsulfonyl)ethylamine hydrochloride

5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde
231278-84-5

5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde

lapatanib
231277-92-2

lapatanib

Conditions
ConditionsYield
Stage #1: 2-(methylsulfonyl)ethylamine hydrochloride With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 0.333333h;
Stage #2: 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde With acetic acid In tetrahydrofuran at 40℃; for 2h;
Stage #3: With sodium tris(acetoxy)borohydride In tetrahydrofuran at 25 - 40℃; for 3h; Concentration;
100%
Stage #1: 2-(methylsulfonyl)ethylamine hydrochloride; 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 50 - 60℃; for 4h;
Stage #2: With sodium cyanoborohydride In isopropyl alcohol at 20℃; for 2h;
92.6%
Stage #1: 2-(methylsulfonyl)ethylamine hydrochloride With sodium sulfate; triethylamine In methanol at 0℃; for 0.333333h;
Stage #2: 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde With formic acid; sodium cyanoborohydride In tetrahydrofuran; methanol; N,N-dimethyl-formamide for 2h; pH=5 - 6;
82%
C27H19ClFN3O3

C27H19ClFN3O3

2-(methylsulfonyl)ethylamine hydrochloride
104458-24-4

2-(methylsulfonyl)ethylamine hydrochloride

lapatanib
231277-92-2

lapatanib

Conditions
ConditionsYield
With triethylamine In dichloromethane at 25 - 30℃; Inert atmosphere;97%
lapatinib ditosylate
388082-78-8

lapatinib ditosylate

lapatanib
231277-92-2

lapatanib

Conditions
ConditionsYield
Stage #1: lapatinib ditosylate In ethyl acetate at 20℃; for 1h;
Stage #2: With sodium carbonate In water; ethyl acetate for 1h;
96.2%
With sodium carbonate In water; acetonitrile at 5 - 40℃; for 3.58333h;91%
With sodium carbonate In water; ethyl acetate at 22 - 70℃; for 3.25h;56%
formaldehyd
50-00-0

formaldehyd

6-(furan-2-yl)-4-[3-chloro-4-(3-fluorobenzyloxy)phenyl]aminoquinazoline

6-(furan-2-yl)-4-[3-chloro-4-(3-fluorobenzyloxy)phenyl]aminoquinazoline

2-(methylsulfonyl)ethylamine hydrochloride
104458-24-4

2-(methylsulfonyl)ethylamine hydrochloride

lapatanib
231277-92-2

lapatanib

Conditions
ConditionsYield
In tetrahydrofuran at 35 - 40℃; for 4h;90.3%
C11H18BNO5S

C11H18BNO5S

N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-iodoquinazolin-4-amine
231278-20-9

N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-iodoquinazolin-4-amine

lapatanib
231277-92-2

lapatanib

Conditions
ConditionsYield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium dihydrogenphosphate In N,N-dimethyl-formamide at 80℃; for 5h; Temperature; Solvent; Reagent/catalyst; Inert atmosphere;89.8%
2-Methanesulfonyl-ethylamine
49773-20-8

2-Methanesulfonyl-ethylamine

5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde
231278-84-5

5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde

lapatanib
231277-92-2

lapatanib

Conditions
ConditionsYield
Stage #1: 2-Methanesulfonyl-ethylamine; 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde In methanol; dichloromethane at 20℃;
Stage #2: With hydrogen In methanol; dichloromethane Inert atmosphere;
85%
Stage #1: 2-Methanesulfonyl-ethylamine; 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde With sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine
Stage #2: With toluene-4-sulfonic acid
80%
Stage #1: 2-Methanesulfonyl-ethylamine; 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde With triethylamine In tetrahydrofuran; methanol for 3h;
Stage #2: With methanol; sodium tetrahydroborate In tetrahydrofuran at 20℃; Cooling with ice;
70%
C18H22N4O3S

C18H22N4O3S

3-chloro-4-(3-fluorobenzyloxy)aniline
202197-26-0

3-chloro-4-(3-fluorobenzyloxy)aniline

lapatanib
231277-92-2

lapatanib

Conditions
ConditionsYield
With acetic acid for 1h; Reflux; Industrial scale;84.2%
N(1)-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-N,N-dimethylformamidine
1227853-05-5

N(1)-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-N,N-dimethylformamidine

2-amino-5-[5-[[[2-(methanesulfonyl)ethyl]amino]methyl]furan-2-yl]benzonitrile

2-amino-5-[5-[[[2-(methanesulfonyl)ethyl]amino]methyl]furan-2-yl]benzonitrile

lapatanib
231277-92-2

lapatanib

Conditions
ConditionsYield
With acetic acid for 1h; Reflux; Industrial scale;82.4%
NEU-0000388

NEU-0000388

lapatanib
231277-92-2

lapatanib

Conditions
ConditionsYield
With 20% palladium hydroxide-activated charcoal; hydrogen In methanol at 20℃; under 2585.81 - 2844.39 Torr;81.67%
N-((5-bromofuran-2-yl)methyl)-2-(methylsulfonyl)ethanamine
845658-68-6

N-((5-bromofuran-2-yl)methyl)-2-(methylsulfonyl)ethanamine

N-[3-chloro-4-[(3-fluorobenzyl)oxy]phenyl]-6-bromo-quinazolin-4-amine
944549-41-1

N-[3-chloro-4-[(3-fluorobenzyl)oxy]phenyl]-6-bromo-quinazolin-4-amine

bis(pinacol)diborane
73183-34-3

bis(pinacol)diborane

lapatanib
231277-92-2

lapatanib

Conditions
ConditionsYield
Stage #1: N-((5-bromofuran-2-yl)methyl)-2-(methylsulfonyl)ethanamine; bis(pinacol)diborane With bis-triphenylphosphine-palladium(II) chloride; potassium acetate In dimethyl sulfoxide at 75℃; for 5h; Inert atmosphere;
Stage #2: N-[3-chloro-4-[(3-fluorobenzyl)oxy]phenyl]-6-bromo-quinazolin-4-amine In dimethyl sulfoxide at 75℃; for 16h; Catalytic behavior; Temperature; Solvent; Reagent/catalyst;
47%
3-chloro-4-(3-fluorobenzyloxy)nitrobenzene
443882-99-3

3-chloro-4-(3-fluorobenzyloxy)nitrobenzene

lapatanib
231277-92-2

lapatanib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: H2 / Pt/C / ethanol; tetrahydrofuran
2: propan-2-ol / 70 °C
3: Pd(OAc)2; PPh3; Et3N / dimethylformamide
4: Na(OAc)3BH; HOAc / CH2Cl2
View Scheme
Multi-step reaction with 5 steps
1.1: platinum on carbon; hydrogen / ethanol / 0.83 h / 1292.9 Torr / High pressure
2.1: isopropyl alcohol / 3.5 h / 70 °C
3.1: bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / 1,4-dioxane / Inert atmosphere; Reflux
4.1: hydrogenchloride / 1,4-dioxane; tetrahydrofuran / 20 °C
5.1: triethylamine / tetrahydrofuran; methanol / 3 h
5.2: 20 °C / Cooling with ice
View Scheme
Multi-step reaction with 3 steps
1.1: iron; hydrogenchloride / ethanol; water / 3 h / 70 °C
2.1: acetic acid / 1.5 h / 90 °C
3.1: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / dimethyl sulfoxide / 5 h / 75 °C / Inert atmosphere
3.2: 16 h / 75 °C
View Scheme
Multi-step reaction with 4 steps
1: zinc; ammonium chloride / ethanol; water / 12 h / 60 °C
2: isopropyl alcohol / Reflux
3: potassium carbonate; palladium diacetate / ethanol; tetrahydrofuran / 2 h / Reflux
4: 20% palladium hydroxide-activated charcoal; hydrogen / methanol / 20 °C / 2585.81 - 2844.39 Torr
View Scheme
4-chloro-6-iodoquinazoline
98556-31-1

4-chloro-6-iodoquinazoline

lapatanib
231277-92-2

lapatanib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: propan-2-ol / 70 °C
2: Pd(OAc)2; PPh3; Et3N / dimethylformamide
3: Na(OAc)3BH; HOAc / CH2Cl2
View Scheme
Multi-step reaction with 3 steps
1: isopropyl alcohol / Reflux
2: potassium carbonate; palladium diacetate / ethanol; tetrahydrofuran / 2 h / Reflux
3: 20% palladium hydroxide-activated charcoal; hydrogen / methanol / 20 °C / 2585.81 - 2844.39 Torr
View Scheme
Multi-step reaction with 4 steps
1.1: toluene / 1 h / 90 °C
1.2: 5 h / 20 - 72 °C
2.1: N-ethyl-N,N-diisopropylamine / palladium 10% on activated carbon / ethanol / 3 h / 70 °C
3.1: tetrahydrofuran; ethanol; water / 4 h / 25 - 65 °C
4.1: acetic acid; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 30 - 35 °C
4.2: 2.25 h / 22 °C
View Scheme
2-chloro-4-nitrophenol
619-08-9

2-chloro-4-nitrophenol

lapatanib
231277-92-2

lapatanib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: K2CO3 / acetonitrile
2: H2 / Pt/C / ethanol; tetrahydrofuran
3: propan-2-ol / 70 °C
4: Pd(OAc)2; PPh3; Et3N / dimethylformamide
5: Na(OAc)3BH; HOAc / CH2Cl2
View Scheme
Multi-step reaction with 6 steps
1.1: potassium carbonate / acetonitrile / 2 h / 20 - 60 °C / Inert atmosphere
2.1: platinum on carbon; hydrogen / ethanol / 0.83 h / 1292.9 Torr / High pressure
3.1: isopropyl alcohol / 3.5 h / 70 °C
4.1: bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / 1,4-dioxane / Inert atmosphere; Reflux
5.1: hydrogenchloride / 1,4-dioxane; tetrahydrofuran / 20 °C
6.1: triethylamine / tetrahydrofuran; methanol / 3 h
6.2: 20 °C / Cooling with ice
View Scheme
Multi-step reaction with 4 steps
1.1: potassium carbonate / acetonitrile / 0.5 h / 20 °C
1.2: Reflux
2.1: iron; hydrogenchloride / ethanol; water / 3 h / 70 °C
3.1: acetic acid / 1.5 h / 90 °C
4.1: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / dimethyl sulfoxide / 5 h / 75 °C / Inert atmosphere
4.2: 16 h / 75 °C
View Scheme
Multi-step reaction with 5 steps
1: potassium carbonate / acetonitrile / 2 h / 60 °C / Inert atmosphere
2: zinc; ammonium chloride / ethanol; water / 12 h / 60 °C
3: isopropyl alcohol / Reflux
4: potassium carbonate; palladium diacetate / ethanol; tetrahydrofuran / 2 h / Reflux
5: 20% palladium hydroxide-activated charcoal; hydrogen / methanol / 20 °C / 2585.81 - 2844.39 Torr
View Scheme
1-(Bromomethyl)-3-fluorobenzene
456-41-7

1-(Bromomethyl)-3-fluorobenzene

lapatanib
231277-92-2

lapatanib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: K2CO3 / acetonitrile
2: H2 / Pt/C / ethanol; tetrahydrofuran
3: propan-2-ol / 70 °C
4: Pd(OAc)2; PPh3; Et3N / dimethylformamide
5: Na(OAc)3BH; HOAc / CH2Cl2
View Scheme
Multi-step reaction with 6 steps
1.1: potassium carbonate / acetonitrile / 2 h / 20 - 60 °C / Inert atmosphere
2.1: platinum on carbon; hydrogen / ethanol / 0.83 h / 1292.9 Torr / High pressure
3.1: isopropyl alcohol / 3.5 h / 70 °C
4.1: bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / 1,4-dioxane / Inert atmosphere; Reflux
5.1: hydrogenchloride / 1,4-dioxane; tetrahydrofuran / 20 °C
6.1: triethylamine / tetrahydrofuran; methanol / 3 h
6.2: 20 °C / Cooling with ice
View Scheme
Multi-step reaction with 4 steps
1.1: potassium carbonate / acetonitrile / 0.5 h / 20 °C
1.2: Reflux
2.1: iron; hydrogenchloride / ethanol; water / 3 h / 70 °C
3.1: acetic acid / 1.5 h / 90 °C
4.1: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / dimethyl sulfoxide / 5 h / 75 °C / Inert atmosphere
4.2: 16 h / 75 °C
View Scheme
Multi-step reaction with 5 steps
1: potassium carbonate / acetonitrile / 2 h / 60 °C / Inert atmosphere
2: zinc; ammonium chloride / ethanol; water / 12 h / 60 °C
3: isopropyl alcohol / Reflux
4: potassium carbonate; palladium diacetate / ethanol; tetrahydrofuran / 2 h / Reflux
5: 20% palladium hydroxide-activated charcoal; hydrogen / methanol / 20 °C / 2585.81 - 2844.39 Torr
View Scheme
N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-iodoquinazolin-4-amine
231278-20-9

N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-iodoquinazolin-4-amine

lapatanib
231277-92-2

lapatanib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Pd(OAc)2; PPh3; Et3N / dimethylformamide
2: Na(OAc)3BH; HOAc / CH2Cl2
View Scheme
Multi-step reaction with 3 steps
1: triethylamine; 1,2-dimethoxyethane / palladium 10% on activated carbon / methanol / Inert atmosphere
2: triethylamine / methanol / 12 h / Reflux
3: methanol / tetrahydrofuran / 0 - 15 °C
View Scheme
Multi-step reaction with 3 steps
1: triethylamine / palladium 10% on activated carbon / 1,2-dimethoxyethane; methanol / 15 h / 45 - 50 °C / Inert atmosphere
2: triethylamine / methanol / 12 h / Reflux
3: sodium tetrahydroborate / tetrahydrofuran; methanol / 4 h / 10 - 15 °C
View Scheme
3-chloro-4-(3-fluorobenzyloxy)aniline
202197-26-0

3-chloro-4-(3-fluorobenzyloxy)aniline

lapatanib
231277-92-2

lapatanib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: propan-2-ol / 70 °C
2: Pd(OAc)2; PPh3; Et3N / dimethylformamide
3: Na(OAc)3BH; HOAc / CH2Cl2
View Scheme
Multi-step reaction with 5 steps
1: acetic acid / toluene / 2 h / Reflux
2: acetic acid / xylene / 10 h / Reflux
3: triethylamine / palladium 10% on activated carbon / 1,2-dimethoxyethane; methanol / 15 h / 45 - 50 °C / Inert atmosphere
4: triethylamine / methanol / 12 h / Reflux
5: sodium tetrahydroborate / tetrahydrofuran; methanol / 4 h / 10 - 15 °C
View Scheme
Multi-step reaction with 4 steps
1.1: isopropyl alcohol / 3.5 h / 70 °C
2.1: bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / 1,4-dioxane / Inert atmosphere; Reflux
3.1: hydrogenchloride / 1,4-dioxane; tetrahydrofuran / 20 °C
4.1: triethylamine / tetrahydrofuran; methanol / 3 h
4.2: 20 °C / Cooling with ice
View Scheme
5-(4-[3-chloro-4-(3-fluorobenzyloxy)-anilino]-6-quinazolinyl)-furan-2-carbaldehyde 4-methylbenzenesulfonate

5-(4-[3-chloro-4-(3-fluorobenzyloxy)-anilino]-6-quinazolinyl)-furan-2-carbaldehyde 4-methylbenzenesulfonate

2-(methylsulfonyl)ethylamine hydrochloride
104458-24-4

2-(methylsulfonyl)ethylamine hydrochloride

lapatanib
231277-92-2

lapatanib

Conditions
ConditionsYield
Stage #1: 5-(4-[3-chloro-4-(3-fluorobenzyloxy)-anilino]-6-quinazolinyl)-furan-2-carbaldehyde 4-methylbenzenesulfonate; 2-(methylsulfonyl)ethylamine hydrochloride With acetic acid; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 30 - 35℃; for 1h;
Stage #2: With sodium tris(acetoxy)borohydride In tetrahydrofuran at 22 - 23℃; for 2.25h;
Stage #3: With sodium hydroxide In tetrahydrofuran; water for 0.5h;
Stage #1: 5-(4-[3-chloro-4-(3-fluorobenzyloxy)-anilino]-6-quinazolinyl)-furan-2-carbaldehyde 4-methylbenzenesulfonate; 2-(methylsulfonyl)ethylamine hydrochloride With sodium acetate; acetic acid In ethyl acetate at 25 - 30℃; for 1h;
Stage #2: With sodium tris(acetoxy)borohydride In ethyl acetate at 25 - 30℃; for 1.5h;
Stage #3: With water; sodium carbonate In ethyl acetate Product distribution / selectivity;
Stage #1: 5-(4-[3-chloro-4-(3-fluorobenzyloxy)-anilino]-6-quinazolinyl)-furan-2-carbaldehyde 4-methylbenzenesulfonate; 2-(methylsulfonyl)ethylamine hydrochloride With acetic acid; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 30 - 35℃; for 1h;
Stage #2: With sodium tris(acetoxy)borohydride In tetrahydrofuran at 22℃; for 2.25h;
N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(5-((2-(methylsulfonyl)ethylimino)methyl)furan-2-yl)quinazolin-4-amine
1227853-06-6

N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(5-((2-(methylsulfonyl)ethylimino)methyl)furan-2-yl)quinazolin-4-amine

lapatanib
231277-92-2

lapatanib

Conditions
ConditionsYield
Stage #1: N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(5-((2-(methylsulfonyl)ethylimino)methyl)furan-2-yl)quinazolin-4-amine With methanol; sodium tetrahydroborate In tetrahydrofuran at 0 - 15℃;
Stage #2: With water In tetrahydrofuran
With methanol In tetrahydrofuran at 0 - 15℃;
With sodium tetrahydroborate In tetrahydrofuran; methanol at 10 - 15℃; for 4h;
anthranilic acid nitrile
1885-29-6

anthranilic acid nitrile

lapatanib
231277-92-2

lapatanib

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: Iodine monochloride; acetic acid / 3 h / 25 - 35 °C
2: 2 h / 70 - 75 °C
3: acetic acid / 2 h / 115 - 120 °C
4: triethylamine; 1,2-dimethoxyethane / palladium 10% on activated carbon / methanol / Inert atmosphere
5: triethylamine / methanol / 12 h / Reflux
6: methanol / tetrahydrofuran / 0 - 15 °C
View Scheme
Multi-step reaction with 5 steps
1: acetic acid / 3 h / 25 - 35 °C
2: acetic acid / xylene / 10 h / Reflux
3: triethylamine / palladium 10% on activated carbon / 1,2-dimethoxyethane; methanol / 15 h / 45 - 50 °C / Inert atmosphere
4: triethylamine / methanol / 12 h / Reflux
5: sodium tetrahydroborate / tetrahydrofuran; methanol / 4 h / 10 - 15 °C
View Scheme
Multi-step reaction with 4 steps
1.1: acetic acid; Iodine monochloride / 3 h / 20 °C
2.1: triethylamine; palladium 10% on activated carbon / methanol; 1,2-dimethoxyethane / 3 h / 20 - 45 °C
2.2: 60 °C
3.1: triethylamine; acetic acid / tetrahydrofuran / 1 h / 20 - 35 °C
3.2: 2.5 h / 22 - 25 °C
4.1: acetic acid / 1 h / Reflux; Industrial scale
View Scheme
5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde
231278-84-5

5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde

lapatanib
231277-92-2

lapatanib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / methanol / 12 h / Reflux
2: methanol / tetrahydrofuran / 0 - 15 °C
View Scheme
Multi-step reaction with 2 steps
1: triethylamine / methanol / 12 h / Reflux
2: sodium tetrahydroborate / tetrahydrofuran; methanol / 4 h / 10 - 15 °C
View Scheme
Multi-step reaction with 2 steps
1.1: tetrahydrofuran; ethanol; water / 4 h / 25 - 65 °C
2.1: acetic acid; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 30 - 35 °C
2.2: 2.25 h / 22 °C
View Scheme
5-iodoanthranilonitrile
132131-24-9

5-iodoanthranilonitrile

lapatanib
231277-92-2

lapatanib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 2 h / 70 - 75 °C
2: acetic acid / 2 h / 115 - 120 °C
3: triethylamine; 1,2-dimethoxyethane / palladium 10% on activated carbon / methanol / Inert atmosphere
4: triethylamine / methanol / 12 h / Reflux
5: methanol / tetrahydrofuran / 0 - 15 °C
View Scheme
Multi-step reaction with 4 steps
1: acetic acid / xylene / 10 h / Reflux
2: triethylamine / palladium 10% on activated carbon / 1,2-dimethoxyethane; methanol / 15 h / 45 - 50 °C / Inert atmosphere
3: triethylamine / methanol / 12 h / Reflux
4: sodium tetrahydroborate / tetrahydrofuran; methanol / 4 h / 10 - 15 °C
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine; palladium 10% on activated carbon / methanol; 1,2-dimethoxyethane / 3 h / 20 - 45 °C
1.2: 60 °C
2.1: triethylamine; acetic acid / tetrahydrofuran / 1 h / 20 - 35 °C
2.2: 2.5 h / 22 - 25 °C
3.1: acetic acid / 1 h / Reflux; Industrial scale
View Scheme
N’-(2-cyano-4-iodophenyl)-N,N-dimethyl formamidine
903597-10-4

N’-(2-cyano-4-iodophenyl)-N,N-dimethyl formamidine

lapatanib
231277-92-2

lapatanib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: acetic acid / 2 h / 115 - 120 °C
2: triethylamine; 1,2-dimethoxyethane / palladium 10% on activated carbon / methanol / Inert atmosphere
3: triethylamine / methanol / 12 h / Reflux
4: methanol / tetrahydrofuran / 0 - 15 °C
View Scheme
Multi-step reaction with 3 steps
1.1: acetic acid / 0.25 h / 125 - 130 °C
2.1: palladium 10% on activated carbon; triethylamine / methanol; 1,2-dimethoxyethane / 0.5 h / 50 °C
3.1: triethylamine; sodium sulfate / methanol / 0.33 h / 0 °C
3.2: 2 h / pH 5 - 6
View Scheme
5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde hydrochloride
388082-76-6

5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde hydrochloride

2-(methylsulfonyl)ethylamine hydrochloride
104458-24-4

2-(methylsulfonyl)ethylamine hydrochloride

lapatanib
231277-92-2

lapatanib

Conditions
ConditionsYield
Stage #1: 2-(methylsulfonyl)ethylamine hydrochloride With acetic acid; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 0.5h;
Stage #2: 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde hydrochloride With water In tetrahydrofuran at 20℃; for 4h;
Stage #3: With sodium tris(acetoxy)borohydride In tetrahydrofuran
N-((5-(4-chloro-quinazoline-6-yl)furan-2-yl)methyl)-2-methylsulfonyl ethylamine
1334953-75-1

N-((5-(4-chloro-quinazoline-6-yl)furan-2-yl)methyl)-2-methylsulfonyl ethylamine

3-chloro-4-(3-fluorobenzyloxy)aniline
202197-26-0

3-chloro-4-(3-fluorobenzyloxy)aniline

lapatanib
231277-92-2

lapatanib

Conditions
ConditionsYield
Stage #1: N-((5-(4-chloro-quinazoline-6-yl)furan-2-yl)methyl)-2-methylsulfonyl ethylamine; 3-chloro-4-(3-fluorobenzyloxy)aniline In toluene; butanone at 20 - 90℃;
Stage #2: With sodium hydroxide In tetrahydrofuran; water; toluene; butanone at 20℃;
5-formylfurane-2-boronic acid
27329-70-0

5-formylfurane-2-boronic acid

lapatanib
231277-92-2

lapatanib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine / palladium 10% on activated carbon / 1,2-dimethoxyethane; methanol / 15 h / 45 - 50 °C / Inert atmosphere
2: triethylamine / methanol / 12 h / Reflux
3: sodium tetrahydroborate / tetrahydrofuran; methanol / 4 h / 10 - 15 °C
View Scheme
Multi-step reaction with 3 steps
1.1: tetrahydrofuran / 2 h / 20 °C
2.1: palladium 10% on activated carbon / methanol / 8 h / Reflux
3.1: N-ethyl-N,N-diisopropylamine; acetic acid / tetrahydrofuran / 1 h / 40 °C
3.2: 3 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: tetrahydrofuran / 2 h / 20 °C
2.1: palladium 10% on activated carbon; N-ethyl-N,N-diisopropylamine / methanol / 8 h / Reflux
3.1: N-ethyl-N,N-diisopropylamine; acetic acid / tetrahydrofuran / 1 h / 40 °C
3.2: 3 h / 20 °C
View Scheme
N(1)-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-N,N-dimethylformamidine
1227853-05-5

N(1)-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-N,N-dimethylformamidine

lapatanib
231277-92-2

lapatanib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: acetic acid / xylene / 10 h / Reflux
2: triethylamine / palladium 10% on activated carbon / 1,2-dimethoxyethane; methanol / 15 h / 45 - 50 °C / Inert atmosphere
3: triethylamine / methanol / 12 h / Reflux
4: sodium tetrahydroborate / tetrahydrofuran; methanol / 4 h / 10 - 15 °C
View Scheme
2-Methanesulfonyl-ethylamine
49773-20-8

2-Methanesulfonyl-ethylamine

5-(4-[3-chloro-4-(3-fluorobenzyloxy)-anilino]-6-quinazolinyl)-furan-2-carbaldehyde tosylate

5-(4-[3-chloro-4-(3-fluorobenzyloxy)-anilino]-6-quinazolinyl)-furan-2-carbaldehyde tosylate

lapatanib
231277-92-2

lapatanib

Conditions
ConditionsYield
Stage #1: 2-Methanesulfonyl-ethylamine; 5-(4-[3-chloro-4-(3-fluorobenzyloxy)-anilino]-6-quinazolinyl)-furan-2-carbaldehyde tosylate With acetic acid; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 30 - 35℃; for 2h;
Stage #2: With sodium tris(acetoxy)borohydride In tetrahydrofuran at 20 - 25℃; for 3h;
Stage #3: With water; sodium hydroxide In tetrahydrofuran
2-(diethoxymethyl)furan
13529-27-6

2-(diethoxymethyl)furan

lapatanib
231277-92-2

lapatanib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: n-butyllithium / 1,2-dimethoxyethane / 2.75 h / -40 - -35 °C / Inert atmosphere
1.2: 2.5 h / -40 - -35 °C
2.1: N-ethyl-N,N-diisopropylamine; acetic acid / tetrahydrofuran / 2 h / 30 - 35 °C
2.2: 3 h / 20 - 25 °C
View Scheme
Multi-step reaction with 3 steps
1.1: n-butyllithium / hexane; 1,2-dimethoxyethane / 5 h / -50 °C / Inert atmosphere
1.2: 6.5 h / -40 - 20 °C / Inert atmosphere
2.1: palladium 10% on activated carbon; N-ethyl-N,N-diisopropylamine / methanol / 8 h / Reflux
3.1: N-ethyl-N,N-diisopropylamine; acetic acid / tetrahydrofuran / 1 h / 40 °C
3.2: 3 h / 20 °C
View Scheme
5-formylfurane-2-boronic acid
27329-70-0

5-formylfurane-2-boronic acid

N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-iodoquinazolin-4-amine
231278-20-9

N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-iodoquinazolin-4-amine

lapatanib
231277-92-2

lapatanib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: palladium 10% on activated carbon; triethylamine / 1,2-dimethoxyethane; methanol / 14 h / 50 °C
2.1: N-ethyl-N,N-diisopropylamine; acetic acid / tetrahydrofuran / 1 h / 40 °C
2.2: 3 h / 20 °C
View Scheme
lapatanib
231277-92-2

lapatanib

lapatinib hydrogen bromide salt
1092929-27-5

lapatinib hydrogen bromide salt

Conditions
ConditionsYield
With hydrogen bromide In tetrahydrofuran; water at 21 - 60℃; for 23.5833h;99.9%
With hydrogen bromide In methanol; water Reflux;83.4%
lapatanib
231277-92-2

lapatanib

lapatinib dihydrochloride

lapatinib dihydrochloride

Conditions
ConditionsYield
With hydrogenchloride In methanol; water Reflux;96.5%
With hydrogenchloride In methanol; water at 20℃;93%
With hydrogenchloride In methanol at 25℃; for 20h;
lapatanib
231277-92-2

lapatanib

lapatinib monohydrochloride
1383531-68-7

lapatinib monohydrochloride

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran; water at 20℃;96%
With hydrogenchloride In methanol; water Reflux;95.2%
lapatanib
231277-92-2

lapatanib

lapatinib nitric acid salt

lapatinib nitric acid salt

Conditions
ConditionsYield
With nitric acid In water; acetonitrile Reflux;95.8%
lapatanib
231277-92-2

lapatanib

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

({5-[4-({3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}amino)quinazolin-6-yl]furan-2-yl}methyl) [2-(methylsulfonyl)ethyl]azanium 4-methylbenzenesulfonate

({5-[4-({3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}amino)quinazolin-6-yl]furan-2-yl}methyl) [2-(methylsulfonyl)ethyl]azanium 4-methylbenzenesulfonate

Conditions
ConditionsYield
In methanol at 20℃;95%
In methanol at 25℃; for 20h;
lapatanib
231277-92-2

lapatanib

benzenesulfonic acid
98-11-3

benzenesulfonic acid

N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine ditosylate

N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine ditosylate

Conditions
ConditionsYield
In acetonitrile at 20℃; Heating;94.5%
lapatanib
231277-92-2

lapatanib

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

lapatinib difumarate

lapatinib difumarate

Conditions
ConditionsYield
In acetonitrile Heating;94.3%
lapatanib
231277-92-2

lapatanib

methanesulfonic acid
75-75-2

methanesulfonic acid

lapatinib dimesylate

lapatinib dimesylate

Conditions
ConditionsYield
In propan-1-ol at 20℃; Product distribution / selectivity; Heating;93.2%
lapatanib
231277-92-2

lapatanib

benzoic acid
65-85-0

benzoic acid

lapatinib dibenzoate

lapatinib dibenzoate

Conditions
ConditionsYield
In tetrahydrofuran; water at 60℃; for 0.5h;93%
lapatanib
231277-92-2

lapatanib

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

lapatinib ditosylate
388082-78-8

lapatinib ditosylate

Conditions
ConditionsYield
In tetrahydrofuran at 20 - 57.5℃;92.5%
In methanol at 45 - 65℃; Reflux;88%
In methanol at 25 - 65℃; for 3h;88%
lapatanib
231277-92-2

lapatanib

(1S)-10-camphorsulfonic acid
3144-16-9

(1S)-10-camphorsulfonic acid

lapatinib (1S)(+)-camphorsulfonic acid salt

lapatinib (1S)(+)-camphorsulfonic acid salt

Conditions
ConditionsYield
In acetone at 20℃; for 24h;89.8%
lapatanib
231277-92-2

lapatanib

ethanesulfonic acid
594-45-6

ethanesulfonic acid

lapatinib diesylate

lapatinib diesylate

Conditions
ConditionsYield
In methanol at 21 - 60℃; for 26.5h;89.3%
lapatanib
231277-92-2

lapatanib

maleic acid
110-16-7

maleic acid

lapatinib dimaleate

lapatinib dimaleate

Conditions
ConditionsYield
In ethanol; water Product distribution / selectivity; Heating;89%
lapatanib
231277-92-2

lapatanib

naphthalene-1,5-disulfonate
81-04-9

naphthalene-1,5-disulfonate

lapatinib naphthalene-1,5-disulfonic acid salt

lapatinib naphthalene-1,5-disulfonic acid salt

Conditions
ConditionsYield
In methanol Reflux;86.5%
lapatanib
231277-92-2

lapatanib

citric acid
77-92-9

citric acid

lapatinib citric acid salt
1092929-12-8

lapatinib citric acid salt

Conditions
ConditionsYield
In methanol for 1h; Concentration; Solvent; Temperature; Reflux;86.2%
In tetrahydrofuran at 21 - 60℃; for 4h; Product distribution / selectivity;62.6%
lapatanib
231277-92-2

lapatanib

methanesulfonic acid
75-75-2

methanesulfonic acid

lapatinib monomesylate
1092928-98-7

lapatinib monomesylate

Conditions
ConditionsYield
In water; acetone at 50 - 55℃; Product distribution / selectivity;85.8%
lapatanib
231277-92-2

lapatanib

naphthalene-2-sulfonate
120-18-3

naphthalene-2-sulfonate

lapatinib naphthalene-2-sulfonic acid salt

lapatinib naphthalene-2-sulfonic acid salt

Conditions
ConditionsYield
In acetonitrile Concentration; Solvent; Reflux;85.4%
lapatanib
231277-92-2

lapatanib

(S)-Malic acid
97-67-6

(S)-Malic acid

lapatinib mono-L-malate
1092929-16-2

lapatinib mono-L-malate

Conditions
ConditionsYield
In isopropyl methanesulfonate; water Product distribution / selectivity; Heating;85.1%
lapatanib
231277-92-2

lapatanib

aspirin
50-78-2

aspirin

alapatinib

alapatinib

Conditions
ConditionsYield
With dmap; diisopropyl-carbodiimide In diethyl ether at -20℃; Reagent/catalyst; Solvent; Temperature; Schlenk technique; Inert atmosphere;85%
lapatanib
231277-92-2

lapatanib

ethanesulfonic acid
594-45-6

ethanesulfonic acid

lapatinib monoesylate
1092929-02-6

lapatinib monoesylate

Conditions
ConditionsYield
In water; acetone at 21℃; for 18.5h; Reflux;84.7%
lapatanib
231277-92-2

lapatanib

(S)-Malic acid
97-67-6

(S)-Malic acid

lapatinib di-L-malate

lapatinib di-L-malate

Conditions
ConditionsYield
In ethyl acetate at 20℃; Heating;84.6%
lapatanib
231277-92-2

lapatanib

malonic acid
141-82-2

malonic acid

lapatinib dimalonate

lapatinib dimalonate

Conditions
ConditionsYield
In ethanol Reflux;83.4%

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