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ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price. 1.Quick response within 24 hours. 2.Best quality in your requirement. 3.We pay more attention on delivery time, and usually ship on time. 4.Free samples will be provided. 5.Ensure specifications an

Lapatinib Ditosylate Monohydrate

Cas:388082-78-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enterprises in

Lapatinib ditosylate monohydrate

Cas:388082-78-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Hysen Pharma co.,Ltd.

Hangzhou Hysen pharma CO.,LTD. is a professional Pharmaceutical company. We are specialized in manufacturing and R&D of API & Intermediates, Contract Manufacturing, Contract Research, and International Trading business as well. *We ow

Lapatinib Ditosylate CAS:388082-78-8

Cas:388082-78-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Lapatinib ditosylate Manufacturer/High quality/Best price/In stock

Cas:388082-78-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu

Lapatinib ditosylate CAS No.388082-78-8

Cas:388082-78-8

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:Yellow powder Package:1kg/foil bag; 1kg/tin ; 25kg/drum ; 25k

Antineoplastic agent Lapatinib ditosylate CAS 388082-78-8 with competitive price

Cas:388082-78-8

Min.Order:1 Kilogram

FOB Price: $700.0

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

Name Lapatinib Synonyms N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine Molecular Formul

Manufacture Lapatinib Ditosylate Monohydrate

Cas:388082-78-8

Min.Order:100 Gram

Negotiable

Type:Other

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Lapatinib Ditosylate

Cas:388082-78-8

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Lapatinib ditosylate 388082-78-8 GMP manufacturer

Cas:388082-78-8

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Lapatinib ditosylate

Cas:388082-78-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

Our advantage: 1: High quality and Competitive price 2: Quality control, GC&HPLC&NMR or as your requested 3: Packing as your requested, and double check before shipment 4: Prompt shipment with professional documents 5: Excellent after-

Lapatinib CAS NO.388082-78-8

Cas:388082-78-8

Min.Order:1 Kilogram

FOB Price: $1.0 / 3.0

Type:Trading Company

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Lapatinib Ditosylate

Cas:388082-78-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:Lapatinib Ditosylate CAS NO:388082-78-8 Grade:Medical scientific research and export Molecular formula:C41H40ClFN4O11S3 Molecular weight:915.4229 Product Quality 12 years of chemical raw materials Mature operation of the industry Syst

Lapatinib Ditosylate/ CAS:388082-78-8/Lapatinib Ditosylate raw material/ high-quality

Cas:388082-78-8

Min.Order:25 Kilogram

FOB Price: $2.0 / 3.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--388082-78-8-- Lapatinib ditosylate in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business rel

TIANFUCHEM--388082-78-8-- Lapatinib ditosylate in stock

Cas:388082-78-8

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc. We are specialized in chemical synthesis, process development of pharmaceu

Lapatinib Ditosylate

Cas:388082-78-8

Min.Order:1 Gram

FOB Price: $2.5 / 3.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be

Lapatinib sitosylate cas 388082-78-8

Cas:388082-78-8

Min.Order:1 Gram

Negotiable

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 388082-78-8 with competitive price

Cas:388082-78-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hubei Vanz Pharm Co.,Ltd

cas 388082-78-8 99% Lapatinib ditosylate powder Product Name: Lapatinib ditosylate CAS: 388082-78-8 MF: C41H40ClFN4O11S3 MW: 925.46 EINECS: 642-915-3 Appearance:white Storage:roo

cas 388082-78-8 99% Lapatinib ditosylate powder

Cas:388082-78-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name: Lapatinib ditosylate monohydrate Synonyms: Lapatinib ditosylate hydrate; N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine bis(4-methylbenzenesulfonate) monohydrate CAS:

Lapatinib ditosylate monohydrate

Cas:388082-78-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...)

388082-78-8CAS NO.: 388082-78-8

Cas:388082-78-8

Min.Order:1 Gram

FOB Price: $5.0

Type:Lab/Research institutions

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

Shanghai Upbio Tech Co.,Ltd

1,In No Less ten years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermedi

High quality Lapatinib Ditosylate 99%

Cas:388082-78-8

Min.Order:100 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

HANWAYS CHEMPHARM CO.,LIMITED

We have two GMP facilities in Hubei Province and cooperative factories in Zhejiang Province We are concentrating on the R&D and technical service of APIs and pharmaceutical intermediates We strive to provide world-class service for every cl

Lapatinib ditosylate CAS No. 388082-78-8

Cas:388082-78-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Trading Company

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Anticancer drugs Lapatinib ditosylate/CAS:388082-78-8

Cas:388082-78-8

Min.Order:500 Gram

FOB Price: $2143.0 / 2345.4

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Lapatinib ditosylate CAS:388082-78-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic int

Lapatinib ditosylate CAS:388082-78-8

Cas:388082-78-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Changchun Artel lmport and Export trade company

1)quick response within 12 hours; 2)quality guarantee: all products are strictly tested by our qc, confirmed by qa and approved by third party lab in china, usa, canada, germany, uk, italy, france etc. 3) oem/odm available; 4) reasonable &amp

Lapatinib ditosylate monohydrate CAS NO.388082-78-8

Cas:388082-78-8

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Lonwin Chemical Group Limited

Lapatinib Ditosylate CAS: 388082-78-8 Specification WATER CONTENT NMT 0.5% w/w 9 SPECIFIC OPTICAL ROTATION Between +108 and +115 measured at 365 nm. 10 R

Factory supply Lapatinib Ditosylate

Cas:388082-78-8

Min.Order:1 Kilogram

Negotiable

Type:Other

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Triumph International Development Limilted

Appearance:Yellow solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:By Sea/Air/Courier Port:Qingdao/Shanghai

Sell/Synthesis Lapatinib ditosylate|388082-78-8 99% Yellow solid

Cas:388082-78-8

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Synthetic route

2-(methylsulfonyl)ethylamine hydrochloride
104458-24-4

2-(methylsulfonyl)ethylamine hydrochloride

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde
231278-84-5

5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde

lapatinib ditosylate
388082-78-8

lapatinib ditosylate

Conditions
ConditionsYield
Stage #1: 2-(methylsulfonyl)ethylamine hydrochloride; 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde With tetrabutylammomium bromide; triethylamine In tetrahydrofuran at 30℃; for 3h;
Stage #2: With sodium tris(acetoxy)borohydride In tetrahydrofuran at 20℃; for 4h;
Stage #3: toluene-4-sulfonic acid In tetrahydrofuran at 50℃; for 1h;
94.9%
Stage #1: 2-(methylsulfonyl)ethylamine hydrochloride; 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde With acetic acid; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 3h;
Stage #2: With sodium tris(acetoxy)borohydride In tetrahydrofuran at 20℃; for 12h;
Stage #3: toluene-4-sulfonic acid In tetrahydrofuran at 20℃; for 12h;
82.8%
Stage #1: 2-(methylsulfonyl)ethylamine hydrochloride; 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde With acetic acid; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; N,N-dimethyl-formamide at 35℃; for 1h;
Stage #2: With sodium tris(acetoxy)borohydride In tetrahydrofuran; N,N-dimethyl-formamide at 20 - 25℃; for 2h;
Stage #3: toluene-4-sulfonic acid
72%
Stage #1: 2-(methylsulfonyl)ethylamine hydrochloride; 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; acetic acid at 30 - 35℃; for 1h;
Stage #2: With sodium tris(acetoxy)borohydride In tetrahydrofuran; acetic acid at 22℃; for 2 - 4h;
Stage #3: toluene-4-sulfonic acid With sodium hydroxide In tetrahydrofuran; acetic acid
2-Methanesulfonyl-ethylamine
49773-20-8

2-Methanesulfonyl-ethylamine

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde
231278-84-5

5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde

lapatinib ditosylate
388082-78-8

lapatinib ditosylate

Conditions
ConditionsYield
Stage #1: 2-Methanesulfonyl-ethylamine; 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde In methanol; dichloromethane at 20℃;
Stage #2: With hydrogen In methanol; dichloromethane Inert atmosphere;
Stage #3: toluene-4-sulfonic acid In methanol; dichloromethane
93%
lapatanib
231277-92-2

lapatanib

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

lapatinib ditosylate
388082-78-8

lapatinib ditosylate

Conditions
ConditionsYield
In tetrahydrofuran at 20 - 57.5℃;92.5%
In methanol at 45 - 65℃; Reflux;88%
In methanol at 25 - 65℃; for 3h;88%
N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazoline-4-amine hydrochloride

N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazoline-4-amine hydrochloride

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

lapatinib ditosylate
388082-78-8

lapatinib ditosylate

Conditions
ConditionsYield
Stage #1: N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazoline-4-amine hydrochloride With sodium hydroxide In water; ethyl acetate pH=~ 10; Inert atmosphere;
Stage #2: toluene-4-sulfonic acid In N,N-dimethyl-formamide at 40℃; for 1h;
90.1%
lapatinib monohydrochloride
1383531-68-7

lapatinib monohydrochloride

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

lapatinib ditosylate
388082-78-8

lapatinib ditosylate

Conditions
ConditionsYield
Stage #1: lapatinib monohydrochloride With sodium hydroxide In water; ethyl acetate pH=10; Inert atmosphere;
Stage #2: toluene-4-sulfonic acid In N,N-dimethyl-formamide at 40℃; for 1h;
90.1%
2-Methanesulfonyl-ethylamine
49773-20-8

2-Methanesulfonyl-ethylamine

5-(4-[3-chloro-4-(3-fluorobenzyloxy)-anilino]-6-quinazolinyl)-furan-2-carbaldehyde tosylate

5-(4-[3-chloro-4-(3-fluorobenzyloxy)-anilino]-6-quinazolinyl)-furan-2-carbaldehyde tosylate

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

lapatinib ditosylate
388082-78-8

lapatinib ditosylate

Conditions
ConditionsYield
Stage #1: 2-Methanesulfonyl-ethylamine; 5-(4-[3-chloro-4-(3-fluorobenzyloxy)-anilino]-6-quinazolinyl)-furan-2-carbaldehyde tosylate With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; isopropyl alcohol for 1h; Industrial scale;
Stage #2: With sodium tris(acetoxy)borohydride; isopropyl alcohol In tetrahydrofuran at 20℃; for 1.66667h; Industrial scale;
Stage #3: toluene-4-sulfonic acid Industrial scale; Further stages;
88%
N’-(2-cyano-4-iodophenyl)-N,N-dimethyl formamidine
903597-10-4

N’-(2-cyano-4-iodophenyl)-N,N-dimethyl formamidine

lapatinib ditosylate
388082-78-8

lapatinib ditosylate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: acetic acid / 2 h / 115 - 120 °C
2: triethylamine; 1,2-dimethoxyethane / palladium 10% on activated carbon / methanol / Inert atmosphere
3: triethylamine / methanol / 12 h / Reflux
4: methanol / tetrahydrofuran / 0 - 15 °C
5: methanol / 3 h / Reflux
View Scheme
5-formylfurane-2-boronic acid
27329-70-0

5-formylfurane-2-boronic acid

lapatinib ditosylate
388082-78-8

lapatinib ditosylate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: triethylamine / palladium 10% on activated carbon / 1,2-dimethoxyethane; methanol / 15 h / 45 - 50 °C / Inert atmosphere
2: triethylamine / methanol / 12 h / Reflux
3: sodium tetrahydroborate / tetrahydrofuran; methanol / 4 h / 10 - 15 °C
4: methanol / 3 h / 25 - 65 °C
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine; palladium / tetrahydrofuran; ethanol / 7 h / 65 °C / Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.33 h / 20 °C
2.2: 2 h / 40 °C
2.3: 3 h / 25 - 40 °C
3.1: tetrahydrofuran / 6 h / 65 °C
View Scheme
Multi-step reaction with 3 steps
1.1: palladium 10% on activated carbon / isopropyl methanesulfonate / 0.08 h
1.2: 3 h / 70 °C
3.1: tetrahydrofuran / 4 h / 20 - 55 °C
View Scheme
Multi-step reaction with 4 steps
1.1: palladium 10% on activated carbon / isopropyl methanesulfonate / 0.08 h
1.2: 3 h / 70 °C
2.1: isopropyl methanesulfonate; water / 4.08 - 4.17 h / 25 - 65 °C
3.1: acetic acid; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 30 - 35 °C
3.2: 2.25 h / 22 - 23 °C
3.3: 0.5 h
4.1: tetrahydrofuran / 4 h / 20 - 55 °C
View Scheme
3-chloro-4-(3-fluorobenzyloxy)aniline
202197-26-0

3-chloro-4-(3-fluorobenzyloxy)aniline

lapatinib ditosylate
388082-78-8

lapatinib ditosylate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: acetic acid / toluene / 2 h / Reflux
2: acetic acid / xylene / 10 h / Reflux
3: triethylamine / palladium 10% on activated carbon / 1,2-dimethoxyethane; methanol / 15 h / 45 - 50 °C / Inert atmosphere
4: triethylamine / methanol / 12 h / Reflux
5: sodium tetrahydroborate / tetrahydrofuran; methanol / 4 h / 10 - 15 °C
6: methanol / 3 h / 25 - 65 °C
View Scheme
Multi-step reaction with 5 steps
1.1: 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 25 °C
1.2: 0.33 - 0.5 h
2.1: palladium 10% on activated carbon / ethanol; water / 0.08 h
2.2: 3 h / 70 °C
3.1: tetrahydrofuran; ethanol; isopropyl methanesulfonate; water / 2.08 h / 20 - 65 °C
4.1: acetic acid; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 30 - 35 °C
4.2: 2 - 4 h / 22 - 23 °C
4.3: 0.5 h
5.1: tetrahydrofuran; water / 3 - 4 h / 20 - 63 °C
View Scheme
Multi-step reaction with 5 steps
1.1: tributyl-amine / toluene / 70 - 80 °C
1.2: 2 h / Heating / reflux
2.1: palladium 10% on activated carbon / ethanol; water / 0.08 h
2.2: 3 h / 70 °C
3.1: tetrahydrofuran; ethanol; isopropyl methanesulfonate; water / 2.08 h / 20 - 65 °C
4.1: acetic acid; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 30 - 35 °C
4.2: 2 - 4 h / 22 - 23 °C
4.3: 0.5 h
5.1: tetrahydrofuran; water / 3 - 4 h / 20 - 63 °C
View Scheme
N(1)-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-N,N-dimethylformamidine
1227853-05-5

N(1)-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-N,N-dimethylformamidine

lapatinib ditosylate
388082-78-8

lapatinib ditosylate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: acetic acid / xylene / 10 h / Reflux
2: triethylamine / palladium 10% on activated carbon / 1,2-dimethoxyethane; methanol / 15 h / 45 - 50 °C / Inert atmosphere
3: triethylamine / methanol / 12 h / Reflux
4: sodium tetrahydroborate / tetrahydrofuran; methanol / 4 h / 10 - 15 °C
5: methanol / 3 h / 25 - 65 °C
View Scheme
2-(diethoxymethyl)furan
13529-27-6

2-(diethoxymethyl)furan

lapatinib ditosylate
388082-78-8

lapatinib ditosylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: n-butyllithium / 1,2-dimethoxyethane / 2.75 h / -40 - -35 °C / Inert atmosphere
1.2: 2.5 h / -40 - -35 °C
2.1: N-ethyl-N,N-diisopropylamine; acetic acid / tetrahydrofuran / 2 h / 30 - 35 °C
2.2: 3 h / 20 - 25 °C
3.1: Isopropyl acetate / 1 h / 65 - 70 °C
View Scheme
6-iodo-4-hydroxyquinazoline
16064-08-7

6-iodo-4-hydroxyquinazoline

lapatinib ditosylate
388082-78-8

lapatinib ditosylate

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: trifluoroacetic acid / toluene / 110 - 115 °C / Molecular sieve; Inert atmosphere
2.1: potassium carbonate / triphenyl-arsane; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 2 h / 60 - 65 °C / Inert atmosphere
3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 - 35 °C / Inert atmosphere
3.2: 2 h / 20 - 25 °C
4.1: toluene-4-sulfonic acid / methanol / 1 h / 25 °C
5.1: trichlorophosphate / toluene / 0.17 h / 20 °C / Inert atmosphere
5.2: 3 h / 30 - 75 °C
6.1: isopropyl alcohol / 4 h / 70 °C / Inert atmosphere
7.1: sodium hydroxide / ethyl acetate; water / pH ~ 10 / Inert atmosphere
7.2: 1 h / 40 °C
View Scheme
Multi-step reaction with 8 steps
1.1: trifluoroacetic acid / toluene / 110 - 115 °C / Molecular sieve; Inert atmosphere
2.1: potassium carbonate / triphenyl-arsane; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 2 h / 60 - 65 °C / Inert atmosphere
3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 - 35 °C / Inert atmosphere
4.1: sodium tris(acetoxy)borohydride / dichloromethane / 2 h / 20 - 25 °C
5.1: toluene-4-sulfonic acid; methanol / 1 h / 25 °C
6.1: triethylamine; trichlorophosphate / toluene / 3 h / 75 °C / Inert atmosphere
7.1: isopropyl alcohol / 4 h / 70 °C / Inert atmosphere
8.1: sodium hydroxide / ethyl acetate; water / pH 10 / Inert atmosphere
8.2: 1 h / 40 °C
View Scheme
Multi-step reaction with 9 steps
1.1: trifluoroacetic acid / toluene / 110 °C / Inert atmosphere
2.1: bis(dibenzylideneacetone)-palladium(0); potassium carbonate; triphenyl-arsane / N,N-dimethyl-formamide / 2 h / 60 - 65 °C / Inert atmosphere
3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 - 35 °C / Inert atmosphere
3.2: 2 h / 20 - 25 °C / Inert atmosphere
4.1: triethylamine / N,N-dimethyl-formamide / 1 h / 20 - 55 °C / Inert atmosphere
5.1: sulfuric acid / acetonitrile / 5.25 h / 40 °C / Inert atmosphere
6.1: trichlorophosphate; triethylamine / 1,4-dioxane / 20 - 100 °C / Inert atmosphere
7.1: 1,4-dioxane / 1 h / 55 - 60 °C / Inert atmosphere
8.1: potassium carbonate / 1,4-dioxane; water / 2 h / 55 - 85 °C / Inert atmosphere
9.1: N,N-dimethyl-formamide / 1 h / 35 - 40 °C / Inert atmosphere
View Scheme
Multi-step reaction with 9 steps
1.1: trifluoroacetic acid / toluene / 110 °C / Inert atmosphere
2.1: bis(dibenzylideneacetone)-palladium(0); potassium carbonate; triphenyl-arsane / N,N-dimethyl-formamide / 2 h / 60 - 65 °C / Inert atmosphere
3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 - 35 °C / Inert atmosphere
3.2: 2 h / 20 - 25 °C / Inert atmosphere
4.1: sulfuric acid; methanol / 2.5 h / 40 - 45 °C / Inert atmosphere
4.2: pH 6-7
5.1: triethylamine / N,N-dimethyl-formamide / 20 - 25 °C / Inert atmosphere
6.1: trichlorophosphate; triethylamine / 1,4-dioxane / 20 - 100 °C / Inert atmosphere
7.1: 1,4-dioxane / 1 h / 55 - 60 °C / Inert atmosphere
8.1: potassium carbonate / 1,4-dioxane; water / 2 h / 55 - 85 °C / Inert atmosphere
9.1: N,N-dimethyl-formamide / 1 h / 35 - 40 °C / Inert atmosphere
View Scheme
2-(methylsulphonyl)-N-({5-[4-(tetrahydro-2H-pyran-2-yloxy)quinazolin-6-yl]furan-2-yl}methyl)ethanamine
1383531-71-2

2-(methylsulphonyl)-N-({5-[4-(tetrahydro-2H-pyran-2-yloxy)quinazolin-6-yl]furan-2-yl}methyl)ethanamine

lapatinib ditosylate
388082-78-8

lapatinib ditosylate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: toluene-4-sulfonic acid / methanol / 1 h / 25 °C
2.1: trichlorophosphate / toluene / 0.17 h / 20 °C / Inert atmosphere
2.2: 3 h / 30 - 75 °C
3.1: isopropyl alcohol / 4 h / 70 °C / Inert atmosphere
4.1: sodium hydroxide / ethyl acetate; water / pH ~ 10 / Inert atmosphere
4.2: 1 h / 40 °C
View Scheme
Multi-step reaction with 4 steps
1.1: toluene-4-sulfonic acid; methanol / 1 h / 25 °C
2.1: triethylamine; trichlorophosphate / toluene / 3 h / 75 °C / Inert atmosphere
3.1: isopropyl alcohol / 4 h / 70 °C / Inert atmosphere
4.1: sodium hydroxide / ethyl acetate; water / pH 10 / Inert atmosphere
4.2: 1 h / 40 °C
View Scheme
Multi-step reaction with 6 steps
1.1: sulfuric acid; methanol / 2.5 h / 40 - 45 °C / Inert atmosphere
1.2: pH 6-7
2.1: triethylamine / N,N-dimethyl-formamide / 20 - 25 °C / Inert atmosphere
3.1: trichlorophosphate; triethylamine / 1,4-dioxane / 20 - 100 °C / Inert atmosphere
4.1: 1,4-dioxane / 1 h / 55 - 60 °C / Inert atmosphere
5.1: potassium carbonate / 1,4-dioxane; water / 2 h / 55 - 85 °C / Inert atmosphere
6.1: N,N-dimethyl-formamide / 1 h / 35 - 40 °C / Inert atmosphere
View Scheme
Multi-step reaction with 6 steps
1: triethylamine / N,N-dimethyl-formamide / 1 h / 20 - 55 °C / Inert atmosphere
2: sulfuric acid / acetonitrile / 5.25 h / 40 °C / Inert atmosphere
3: trichlorophosphate; triethylamine / 1,4-dioxane / 20 - 100 °C / Inert atmosphere
4: 1,4-dioxane / 1 h / 55 - 60 °C / Inert atmosphere
5: potassium carbonate / 1,4-dioxane; water / 2 h / 55 - 85 °C / Inert atmosphere
6: N,N-dimethyl-formamide / 1 h / 35 - 40 °C / Inert atmosphere
View Scheme
5-[4-(tetrahydro-2H-pyran-2-yloxy)quinazolin-6-yl]furan-2-carbaldehyde
1383531-70-1

5-[4-(tetrahydro-2H-pyran-2-yloxy)quinazolin-6-yl]furan-2-carbaldehyde

lapatinib ditosylate
388082-78-8

lapatinib ditosylate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 - 35 °C / Inert atmosphere
1.2: 2 h / 20 - 25 °C
2.1: toluene-4-sulfonic acid / methanol / 1 h / 25 °C
3.1: trichlorophosphate / toluene / 0.17 h / 20 °C / Inert atmosphere
3.2: 3 h / 30 - 75 °C
4.1: isopropyl alcohol / 4 h / 70 °C / Inert atmosphere
5.1: sodium hydroxide / ethyl acetate; water / pH ~ 10 / Inert atmosphere
5.2: 1 h / 40 °C
View Scheme
Multi-step reaction with 6 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 - 35 °C / Inert atmosphere
2.1: sodium tris(acetoxy)borohydride / dichloromethane / 2 h / 20 - 25 °C
3.1: toluene-4-sulfonic acid; methanol / 1 h / 25 °C
4.1: triethylamine; trichlorophosphate / toluene / 3 h / 75 °C / Inert atmosphere
5.1: isopropyl alcohol / 4 h / 70 °C / Inert atmosphere
6.1: sodium hydroxide / ethyl acetate; water / pH 10 / Inert atmosphere
6.2: 1 h / 40 °C
View Scheme
Multi-step reaction with 7 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 - 35 °C / Inert atmosphere
1.2: 2 h / 20 - 25 °C / Inert atmosphere
2.1: triethylamine / N,N-dimethyl-formamide / 1 h / 20 - 55 °C / Inert atmosphere
3.1: sulfuric acid / acetonitrile / 5.25 h / 40 °C / Inert atmosphere
4.1: trichlorophosphate; triethylamine / 1,4-dioxane / 20 - 100 °C / Inert atmosphere
5.1: 1,4-dioxane / 1 h / 55 - 60 °C / Inert atmosphere
6.1: potassium carbonate / 1,4-dioxane; water / 2 h / 55 - 85 °C / Inert atmosphere
7.1: N,N-dimethyl-formamide / 1 h / 35 - 40 °C / Inert atmosphere
View Scheme
Multi-step reaction with 7 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 - 35 °C / Inert atmosphere
1.2: 2 h / 20 - 25 °C / Inert atmosphere
2.1: sulfuric acid; methanol / 2.5 h / 40 - 45 °C / Inert atmosphere
2.2: pH 6-7
3.1: triethylamine / N,N-dimethyl-formamide / 20 - 25 °C / Inert atmosphere
4.1: trichlorophosphate; triethylamine / 1,4-dioxane / 20 - 100 °C / Inert atmosphere
5.1: 1,4-dioxane / 1 h / 55 - 60 °C / Inert atmosphere
6.1: potassium carbonate / 1,4-dioxane; water / 2 h / 55 - 85 °C / Inert atmosphere
7.1: N,N-dimethyl-formamide / 1 h / 35 - 40 °C / Inert atmosphere
View Scheme
6-[5-({[2-(methylsulphonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-ol
1334953-74-0

6-[5-({[2-(methylsulphonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-ol

lapatinib ditosylate
388082-78-8

lapatinib ditosylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: trichlorophosphate / toluene / 0.17 h / 20 °C / Inert atmosphere
1.2: 3 h / 30 - 75 °C
2.1: isopropyl alcohol / 4 h / 70 °C / Inert atmosphere
3.1: sodium hydroxide / ethyl acetate; water / pH ~ 10 / Inert atmosphere
3.2: 1 h / 40 °C
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine; trichlorophosphate / toluene / 3 h / 75 °C / Inert atmosphere
2.1: isopropyl alcohol / 4 h / 70 °C / Inert atmosphere
3.1: sodium hydroxide / ethyl acetate; water / pH 10 / Inert atmosphere
3.2: 1 h / 40 °C
View Scheme
Multi-step reaction with 4 steps
1.1: dmap / tetrahydrofuran / 2.5 h / 25 - 30 °C / Inert atmosphere
2.1: thionyl chloride; N,N-dimethyl-formamide / chloroform / 5.75 h / Reflux; Inert atmosphere
3.1: tetrahydrofuran / 25 - 65 °C / Inert atmosphere
4.1: water; sodium hydroxide / methanol / 2 h / 25 - 30 °C / Reflux
4.2: 3.5 h / 45 - 50 °C / Reflux
View Scheme
Multi-step reaction with 5 steps
1: triethylamine / N,N-dimethyl-formamide / 20 - 25 °C / Inert atmosphere
2: trichlorophosphate; triethylamine / 1,4-dioxane / 20 - 100 °C / Inert atmosphere
3: 1,4-dioxane / 1 h / 55 - 60 °C / Inert atmosphere
4: potassium carbonate / 1,4-dioxane; water / 2 h / 55 - 85 °C / Inert atmosphere
5: N,N-dimethyl-formamide / 1 h / 35 - 40 °C / Inert atmosphere
View Scheme
6-iodo-4-(tetrahydro-2H-pyran-2-yloxy)quinazoline
1383531-69-8

6-iodo-4-(tetrahydro-2H-pyran-2-yloxy)quinazoline

lapatinib ditosylate
388082-78-8

lapatinib ditosylate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: potassium carbonate / triphenyl-arsane; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 2 h / 60 - 65 °C / Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 - 35 °C / Inert atmosphere
2.2: 2 h / 20 - 25 °C
3.1: toluene-4-sulfonic acid / methanol / 1 h / 25 °C
4.1: trichlorophosphate / toluene / 0.17 h / 20 °C / Inert atmosphere
4.2: 3 h / 30 - 75 °C
5.1: isopropyl alcohol / 4 h / 70 °C / Inert atmosphere
6.1: sodium hydroxide / ethyl acetate; water / pH ~ 10 / Inert atmosphere
6.2: 1 h / 40 °C
View Scheme
Multi-step reaction with 7 steps
1.1: potassium carbonate / triphenyl-arsane; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 2 h / 60 - 65 °C / Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 - 35 °C / Inert atmosphere
3.1: sodium tris(acetoxy)borohydride / dichloromethane / 2 h / 20 - 25 °C
4.1: toluene-4-sulfonic acid; methanol / 1 h / 25 °C
5.1: triethylamine; trichlorophosphate / toluene / 3 h / 75 °C / Inert atmosphere
6.1: isopropyl alcohol / 4 h / 70 °C / Inert atmosphere
7.1: sodium hydroxide / ethyl acetate; water / pH 10 / Inert atmosphere
7.2: 1 h / 40 °C
View Scheme
Multi-step reaction with 8 steps
1.1: bis(dibenzylideneacetone)-palladium(0); potassium carbonate; triphenyl-arsane / N,N-dimethyl-formamide / 2 h / 60 - 65 °C / Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 - 35 °C / Inert atmosphere
2.2: 2 h / 20 - 25 °C / Inert atmosphere
3.1: sulfuric acid; methanol / 2.5 h / 40 - 45 °C / Inert atmosphere
3.2: pH 6-7
4.1: triethylamine / N,N-dimethyl-formamide / 20 - 25 °C / Inert atmosphere
5.1: trichlorophosphate; triethylamine / 1,4-dioxane / 20 - 100 °C / Inert atmosphere
6.1: 1,4-dioxane / 1 h / 55 - 60 °C / Inert atmosphere
7.1: potassium carbonate / 1,4-dioxane; water / 2 h / 55 - 85 °C / Inert atmosphere
8.1: N,N-dimethyl-formamide / 1 h / 35 - 40 °C / Inert atmosphere
View Scheme
Multi-step reaction with 8 steps
1.1: bis(dibenzylideneacetone)-palladium(0); potassium carbonate; triphenyl-arsane / N,N-dimethyl-formamide / 2 h / 60 - 65 °C / Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 - 35 °C / Inert atmosphere
2.2: 2 h / 20 - 25 °C / Inert atmosphere
3.1: triethylamine / N,N-dimethyl-formamide / 1 h / 20 - 55 °C / Inert atmosphere
4.1: sulfuric acid / acetonitrile / 5.25 h / 40 °C / Inert atmosphere
5.1: trichlorophosphate; triethylamine / 1,4-dioxane / 20 - 100 °C / Inert atmosphere
6.1: 1,4-dioxane / 1 h / 55 - 60 °C / Inert atmosphere
7.1: potassium carbonate / 1,4-dioxane; water / 2 h / 55 - 85 °C / Inert atmosphere
8.1: N,N-dimethyl-formamide / 1 h / 35 - 40 °C / Inert atmosphere
View Scheme
C21H23N3O5S

C21H23N3O5S

lapatinib ditosylate
388082-78-8

lapatinib ditosylate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium tris(acetoxy)borohydride / dichloromethane / 2 h / 20 - 25 °C
2.1: toluene-4-sulfonic acid; methanol / 1 h / 25 °C
3.1: triethylamine; trichlorophosphate / toluene / 3 h / 75 °C / Inert atmosphere
4.1: isopropyl alcohol / 4 h / 70 °C / Inert atmosphere
5.1: sodium hydroxide / ethyl acetate; water / pH 10 / Inert atmosphere
5.2: 1 h / 40 °C
View Scheme
4-chloro-6-iodoquinazoline
98556-31-1

4-chloro-6-iodoquinazoline

lapatinib ditosylate
388082-78-8

lapatinib ditosylate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: acetonitrile / 1 h / Reflux
2.1: triethylamine; palladium 10% on activated carbon / water; 1,2-dimethoxyethane; methanol / 45 - 50 °C
3.1: water / 20 - 30 °C
4.1: N-ethyl-N,N-diisopropylamine / methanol / 20 h / 20 - 25 °C
5.1: sodium hydroxide / methanol / 20 h / 20 - 25 °C
6.1: sodium tris(acetoxy)borohydride / tetrahydrofuran / 1 h / 20 - 25 °C
6.3: 3 h
View Scheme
Multi-step reaction with 5 steps
1.1: toluene / 1 h / 90 °C
1.2: 5 h / 20 - 72 °C
2.1: N-ethyl-N,N-diisopropylamine / palladium 10% on activated carbon / ethanol / 3 h / 70 °C
3.1: tetrahydrofuran; ethanol; water / 4 h / 25 - 65 °C
4.1: acetic acid; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 30 - 35 °C
4.2: 2.25 h / 22 °C
5.1: tetrahydrofuran; water / 3.5 h / 20 - 60 °C
View Scheme
Multi-step reaction with 5 steps
1.1: toluene / 1 h / 90 °C
1.2: 3 h / 20 - 72 °C
2.1: N-ethyl-N,N-diisopropylamine / palladium 10% on activated carbon / ethanol / 3 h / 70 °C
3.1: ethanol; water / 4 h / 25 - 65 °C
4.1: acetic acid; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 30 - 35 °C
4.2: 2.25 h / 22 °C
5.1: tetrahydrofuran; water / 2.5 h / 60 °C
View Scheme
2-chloro 4-aminophenol
3964-52-1

2-chloro 4-aminophenol

lapatinib ditosylate
388082-78-8

lapatinib ditosylate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: acetonitrile / 1 h / Reflux
2.1: triethylamine; palladium 10% on activated carbon / water; 1,2-dimethoxyethane; methanol / 45 - 50 °C
3.1: water / 20 - 30 °C
4.1: N-ethyl-N,N-diisopropylamine / methanol / 20 h / 20 - 25 °C
5.1: sodium hydroxide / methanol / 20 h / 20 - 25 °C
6.1: sodium tris(acetoxy)borohydride / tetrahydrofuran / 1 h / 20 - 25 °C
6.3: 3 h
View Scheme
2-chloro-4-(6-iodoquinazolin-4-ylamino)phenol
908332-08-1

2-chloro-4-(6-iodoquinazolin-4-ylamino)phenol

lapatinib ditosylate
388082-78-8

lapatinib ditosylate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: triethylamine; palladium 10% on activated carbon / water; 1,2-dimethoxyethane; methanol / 45 - 50 °C
2.1: water / 20 - 30 °C
3.1: N-ethyl-N,N-diisopropylamine / methanol / 20 h / 20 - 25 °C
4.1: sodium hydroxide / methanol / 20 h / 20 - 25 °C
5.1: sodium tris(acetoxy)borohydride / tetrahydrofuran / 1 h / 20 - 25 °C
5.3: 3 h
View Scheme
lapatinib ditosylate
388082-78-8

lapatinib ditosylate

N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulphonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine bis(4-methylbenzenesulphonate) monohydrate

N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulphonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine bis(4-methylbenzenesulphonate) monohydrate

Conditions
ConditionsYield
With water100%
With water In tetrahydrofuran at 55 - 60℃; for 0.5h;
With water In tetrahydrofuran at 5 - 64℃; for 2.5 - 4h; Heating / reflux;
lapatinib ditosylate
388082-78-8

lapatinib ditosylate

lapatanib
231277-92-2

lapatanib

Conditions
ConditionsYield
Stage #1: lapatinib ditosylate In ethyl acetate at 20℃; for 1h;
Stage #2: With sodium carbonate In water; ethyl acetate for 1h;
96.2%
With sodium carbonate In water; acetonitrile at 5 - 40℃; for 3.58333h;91%
With sodium carbonate In water; ethyl acetate at 22 - 70℃; for 3.25h;56%

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