2-Aminoethylmethylsulfone hydrochloride supplier

Name
2-Aminoethylmethylsulfone hydrochloride
EINECS 1806241-263-5
CAS No. 104458-24-4
Article Data9
CAS DataBase
Density
Solubility
Melting Point 168.0 to 172.0 °C
Formula C₃H₉NO₂S^.HCl
Boiling Point 325.8 °C at 760 mmHg
Molecular Weight 159.637
Flash Point 150.8 °C
Transport Information
Appearance power
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Ethanamine,2-(methylsulfonyl)-, hydrochloride (9CI);2-(Methylsulfonyl)ethanaminehydrochloride;2-(Methylsulfonyl)ethylamine hydrochloride;2-Aminoethyl methylsulfone hydrochloride;2-aminoethylmethylsulfone hydrochloride;
PSA 68.54000
LogP 1.57280

Synthetic route

: 154095-06-4
tert-butyl 2-(methylsulfonyl)ethylcarbamate

: 104458-24-4
2-(methylsulfonyl)ethylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In ethyl acetate at 0 - 20℃;	97%
With hydrogenchloride In ethanol at 20℃; Temperature;	88%
With hydrogenchloride In diethyl ether; ethyl acetate at 20℃;	78%

: 18542-42-2
(2-aminoethyl)methylsulfide

: 104458-24-4
2-(methylsulfonyl)ethylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; dihydrogen peroxide In water at 25 - 30℃; pH=3 - 4; Solvent;	94.8%

: 2-<2-(methylsulfonyl)ethyl>-1H-isoindole-1,3(2H)dione

: 104458-24-4
2-(methylsulfonyl)ethylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; water at 100℃; for 10h; Reagent/catalyst; Temperature;	92.1%
With hydrogenchloride In water at 100℃; for 10h;	92.1%

hydrochloride of methyl-<β-amino-ethyl>-sulfide: hydrochloride of methyl-<β-amino-ethyl>-sulfide

: 104458-24-4
2-(methylsulfonyl)ethylamine hydrochloride

Conditions

Conditions	Yield
With potassium permanganate; water

: 49773-20-8
2-Methanesulfonyl-ethylamine

: 104458-24-4
2-(methylsulfonyl)ethylamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol Product distribution / selectivity;

: 104458-24-4
2-(methylsulfonyl)ethylamine hydrochloride

: 231278-84-5
5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde

: 231277-92-2
lapatanib

Conditions

Conditions	Yield
Stage #1: 2-(methylsulfonyl)ethylamine hydrochloride With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 0.333333h; Stage #2: 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde With acetic acid In tetrahydrofuran at 40℃; for 2h; Stage #3: With sodium tris(acetoxy)borohydride In tetrahydrofuran at 25 - 40℃; for 3h; Concentration;	100%
Stage #1: 2-(methylsulfonyl)ethylamine hydrochloride; 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 50 - 60℃; for 4h; Stage #2: With sodium cyanoborohydride In isopropyl alcohol at 20℃; for 2h;	92.6%
Stage #1: 2-(methylsulfonyl)ethylamine hydrochloride With sodium sulfate; triethylamine In methanol at 0℃; for 0.333333h; Stage #2: 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde With formic acid; sodium cyanoborohydride In tetrahydrofuran; methanol; N,N-dimethyl-formamide for 2h; pH=5 - 6;	82%

: 1440511-82-9
5-(4-(3-chloro-4-hydroxyphenylamino)quinazolin-6-yl)furan-2-carbaldehyde tosylate

: 104458-24-4
2-(methylsulfonyl)ethylamine hydrochloride

: 1440511-83-0
2-chloro-4-(6-(5-((2-(methylsulfonyl)ethylimino)methyl)furan-2-yl)quinazolin-4-ylamino)phenol

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In methanol at 20 - 25℃; for 20h;	97.1%

: C27H19ClFN3O3

: 104458-24-4
2-(methylsulfonyl)ethylamine hydrochloride

: 231277-92-2
lapatanib

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 25 - 30℃; Inert atmosphere;	97%

: 104458-24-4
2-(methylsulfonyl)ethylamine hydrochloride

: 231278-84-5
5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde

: 1227853-06-6
N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(5-((2-(methylsulfonyl)ethylimino)methyl)furan-2-yl)quinazolin-4-amine

Conditions

Conditions	Yield
With triethylamine In methanol for 12h; Reflux;	96%
With triethylamine In methanol for 12h; Reflux;	96%
With triethylamine In methanol for 12h; Reflux;

: 104458-24-4
2-(methylsulfonyl)ethylamine hydrochloride

: 104-15-4
toluene-4-sulfonic acid

: 231278-84-5
5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde

: 388082-78-8
lapatinib ditosylate

Conditions

Conditions	Yield
Stage #1: 2-(methylsulfonyl)ethylamine hydrochloride; 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde With tetrabutylammomium bromide; triethylamine In tetrahydrofuran at 30℃; for 3h; Stage #2: With sodium tris(acetoxy)borohydride In tetrahydrofuran at 20℃; for 4h; Stage #3: toluene-4-sulfonic acid In tetrahydrofuran at 50℃; for 1h;	94.9%
Stage #1: 2-(methylsulfonyl)ethylamine hydrochloride; 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde With acetic acid; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 3h; Stage #2: With sodium tris(acetoxy)borohydride In tetrahydrofuran at 20℃; for 12h; Stage #3: toluene-4-sulfonic acid In tetrahydrofuran at 20℃; for 12h;	82.8%
Stage #1: 2-(methylsulfonyl)ethylamine hydrochloride; 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde With acetic acid; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; N,N-dimethyl-formamide at 35℃; for 1h; Stage #2: With sodium tris(acetoxy)borohydride In tetrahydrofuran; N,N-dimethyl-formamide at 20 - 25℃; for 2h; Stage #3: toluene-4-sulfonic acid	72%
Stage #1: 2-(methylsulfonyl)ethylamine hydrochloride; 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; acetic acid at 30 - 35℃; for 1h; Stage #2: With sodium tris(acetoxy)borohydride In tetrahydrofuran; acetic acid at 22℃; for 2 - 4h; Stage #3: toluene-4-sulfonic acid With sodium hydroxide In tetrahydrofuran; acetic acid

...Expand

: 1899-24-7
5-bromo-2-furancarboxaldehyde

: 104458-24-4
2-(methylsulfonyl)ethylamine hydrochloride

: (E)-N-((5-bromofuran-2-yl)methylene)-2-(methylsulfonyl)ethylamine

Conditions

Conditions	Yield
Stage #1: 5-bromo-2-furancarboxaldehyde; 2-(methylsulfonyl)ethylamine hydrochloride With magnesium sulfate In dichloromethane at -5℃; for 2h; Inert atmosphere; Stage #2: With triethylamine In dichloromethane at -5℃; for 2h; Inert atmosphere;	94.25%

: 1446358-48-0
3-(3-(4-chloro-5-fluoropyrimidin-2-yl)-1-(2-fluorobenzyl)-1H-pyrazol-5-yl)isoxazole

: 104458-24-4
2-(methylsulfonyl)ethylamine hydrochloride

: C20H18F2N6O3S

Conditions

Conditions	Yield
With triethylamine In 1,4-dioxane; water at 100℃; for 17h;	91%

: 50-00-0
formaldehyd

: 6-(furan-2-yl)-4-[3-chloro-4-(3-fluorobenzyloxy)phenyl]aminoquinazoline

: 104458-24-4
2-(methylsulfonyl)ethylamine hydrochloride

: 231277-92-2
lapatanib

Conditions

Conditions	Yield
In tetrahydrofuran at 35 - 40℃; for 4h;	90.3%

...Expand

: 104458-24-4
2-(methylsulfonyl)ethylamine hydrochloride

: 219946-62-0
D-arabinono-1,4-lactone 5-(dihydrogenophosphate)

: N-(5-phosphate-D-arabinoyl)-2-(methylsulfonyl)ethanamine

Conditions

Conditions	Yield
Stage #1: 2-(methylsulfonyl)ethylamine hydrochloride With sodium methylate at 35℃; Inert atmosphere; Stage #2: D-arabinono-1,4-lactone 5-(dihydrogenophosphate) With methanol at 20℃; for 1.5h; Inert atmosphere;	89%

: 16588-16-2
ethyl 4-chloro-3-nitrobenzoate

: 104458-24-4
2-(methylsulfonyl)ethylamine hydrochloride

: ethyl 4-((2-(methylsulfonyl)ethyl)amino)-3-nitrobenzoate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 60℃; for 16h;	89%

: 104458-24-4
2-(methylsulfonyl)ethylamine hydrochloride

: 5453-04-3, 866541-93-7, 1189561-66-7
(±)-gossypol acetic acid

: C36H44N2O10S2

Conditions

Conditions	Yield
Stage #1: 2-(methylsulfonyl)ethylamine hydrochloride With sodium hydroxide In ethanol for 1h; Reflux; Stage #2: (±)-gossypol acetic acid In ethanol for 5h; Reflux;	86.8%

: 650626-22-5
4-((E)-{[1-(3-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]hydrazono}methyl)benzoic acid

: 104458-24-4
2-(methylsulfonyl)ethylamine hydrochloride

: 4-((E)-{[1-(3-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]hydrazono}methyl)-N-[2-(methylsulfonyl)ethyl]benzamide

Conditions

Conditions	Yield
With diethyl cyanophosphonate; triethylamine In DMF (N,N-dimethyl-formamide) at 20℃; for 16h;	84%

: 104458-24-4
2-(methylsulfonyl)ethylamine hydrochloride

: 104-15-4
toluene-4-sulfonic acid

: 231278-84-5
5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde

: N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulphonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine bis(4-methylbenzenesulphonate) monohydrate

Conditions

Conditions	Yield
Stage #1: 2-(methylsulfonyl)ethylamine hydrochloride; 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde With acetic acid; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 3h; Stage #2: With sodium tris(acetoxy)borohydride In tetrahydrofuran at 20℃; for 12h; Stage #3: toluene-4-sulfonic acid With water In tetrahydrofuran at 20℃; for 12h;	82.8%

...Expand

: 2-amino-5-[(5-formyl)furan-2-yl]benzonitrile p-toluenesulfonic acid

: 104458-24-4
2-(methylsulfonyl)ethylamine hydrochloride

: 2-amino-5-[5-[[[2-(methanesulfonyl)ethyl]amino]methyl]furan-2-yl]benzonitrile

Conditions

Conditions	Yield
Stage #1: 2-amino-5-[(5-formyl)furan-2-yl]benzonitrile p-toluenesulfonic acid; 2-(methylsulfonyl)ethylamine hydrochloride With acetic acid; triethylamine In tetrahydrofuran at 20 - 35℃; for 1h; Stage #2: With sodium tris(acetoxy)borohydride In tetrahydrofuran at 22 - 25℃; for 2.5h;	82.7%

: 4-(4-(E)-(propen-1-yl)phenylamino)-6-(5-formylfuran-2-yl)quinazoline

: 104458-24-4
2-(methylsulfonyl)ethylamine hydrochloride

: 4-(4-(E)-(propen-1-yl)phenylamino)-6-(5-((2-(methylsulfonyl)ethyl)aminomethyl)furan-2-yl)quinazoline

Conditions

Conditions	Yield
Stage #1: 2-(methylsulfonyl)ethylamine hydrochloride With sodium sulfate; triethylamine In methanol at 0℃; for 0.333333h; Stage #2: 4-(4-(E)-(propen-1-yl)phenylamino)-6-(5-formylfuran-2-yl)quinazoline With formic acid; sodium cyanoborohydride In tetrahydrofuran; methanol; N,N-dimethyl-formamide for 2h; pH=5 - 6;	82.6%

: 650637-47-1
4-((E)-{[1-(6-methoxypyridin-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]hydrazono}methyl)benzoic acid

: 104458-24-4
2-(methylsulfonyl)ethylamine hydrochloride

: 4-((E)-{[1-(6-methoxypyridin-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]hydrazono}methyl)-N-[2-(methylsulfonyl)ethyl]benzamide

Conditions

Conditions	Yield
With diethyl cyanophosphonate; triethylamine In DMF (N,N-dimethyl-formamide) at 20℃; for 16h;	81%

: 4-((E)-{[1-(2-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]hydrazono}methyl)benzoic acid

: 104458-24-4
2-(methylsulfonyl)ethylamine hydrochloride

: 4-((E)-{[1-(2-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]hydrazono}methyl)-N-[2-(methylsulfonyl)ethyl]benzamide hydrochloride

Conditions

Conditions	Yield
Stage #1: 4-((E)-{[1-(2-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]hydrazono}methyl)benzoic acid; 2-(methylsulfonyl)ethylamine hydrochloride With diethyl cyanophosphonate; triethylamine In DMF (N,N-dimethyl-formamide) at 20℃; for 16h; Stage #2: With hydrogenchloride In water	81%

: 104458-24-4
2-(methylsulfonyl)ethylamine hydrochloride

: 650627-05-7
4-((E)-{[1-(3-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]hydrazono}methyl)benzoic acid

: 4-((E)-{[1-(3-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]hydrazono}methyl)-N-[2-(methylsulfonyl)ethyl]benzamide

Conditions

Conditions	Yield
With diethyl cyanophosphonate; triethylamine In DMF (N,N-dimethyl-formamide) at 20℃; for 16h;	81%

: 650626-44-1
4-((E)-{[1-(3-nitrophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]hydrazono}methyl)benzoic acid

: 104458-24-4
2-(methylsulfonyl)ethylamine hydrochloride

: N-[2-(methylsulfonyl)ethyl]-4-((E)-{[1-(3-nitrophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]hydrazono}methyl)benzamide

Conditions

Conditions	Yield
With diethyl cyanophosphonate; triethylamine In DMF (N,N-dimethyl-formamide) at 20℃; for 16h;	80%

: 104458-24-4
2-(methylsulfonyl)ethylamine hydrochloride

: 104-15-4
toluene-4-sulfonic acid

: N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulphonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine bis(4-methylbenzenesulphonate) monohydrate

Conditions

Conditions	Yield
Stage #1: 5-(4-[3-chloro-4-(3-fluorobenzyloxy)-anilino]-6-quinazolinyl)-furan-2-carbaldehyde 4-methylbenzenesulfonate; 2-(methylsulfonyl)ethylamine hydrochloride With acetic acid; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 30 - 35℃; for 1h; Stage #2: With sodium tris(acetoxy)borohydride In tetrahydrofuran at 22℃; for 2h; Stage #3: toluene-4-sulfonic acid With sodium hydroxide; water more than 3 stages;	80%

Yield

Stage #1: 5-(4-[3-chloro-4-(3-fluorobenzyloxy)-anilino]-6-quinazolinyl)-furan-2-carbaldehyde 4-methylbenzenesulfonate; 2-(methylsulfonyl)ethylamine hydrochloride With acetic acid; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 30 - 35℃; for 1h;
Stage #2: With sodium tris(acetoxy)borohydride In tetrahydrofuran at 22℃; for 2h;
Stage #3: toluene-4-sulfonic acid With sodium hydroxide; water more than 3 stages;

80%

: 1383531-70-1
5-[4-(tetrahydro-2H-pyran-2-yloxy)quinazolin-6-yl]furan-2-carbaldehyde

: 104458-24-4
2-(methylsulfonyl)ethylamine hydrochloride

: 1383531-71-2
2-(methylsulphonyl)-N-({5-[4-(tetrahydro-2H-pyran-2-yloxy)quinazolin-6-yl]furan-2-yl}methyl)ethanamine

Conditions

Conditions	Yield
Stage #1: 5-[4-(tetrahydro-2H-pyran-2-yloxy)quinazolin-6-yl]furan-2-carbaldheyde; 2-(methylsulfonyl)ethylamine hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 20 - 35℃; for 0.5h; Inert atmosphere; Stage #2: With sodium tris(acetoxy)borohydride In dichloromethane at 20 - 25℃; for 2h; Stage #3: With sodium hydrogencarbonate In dichloromethane	80%
Stage #1: 5-[4-(tetrahydro-2H-pyran-2-yloxy)quinazolin-6-yl]furan-2-carbaldheyde; 2-(methylsulfonyl)ethylamine hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 30 - 35℃; for 0.5h; Inert atmosphere; Stage #2: With sodium tris(acetoxy)borohydride In dichloromethane at 20 - 25℃; for 2h;	80%
Stage #1: 5-[4-(tetrahydro-2H-pyran-2-yloxy)quinazolin-6-yl]furan-2-carbaldheyde; 2-(methylsulfonyl)ethylamine hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 20 - 35℃; for 0.5h; Inert atmosphere; Stage #2: With sodium tris(acetoxy)borohydride In dichloromethane at 20 - 25℃; for 2h; Inert atmosphere;	80%

: 4-(3-ethynyl-phenylamino)-6-(5-formylfuran-2-yl)quinazoline

: 104458-24-4
2-(methylsulfonyl)ethylamine hydrochloride

: 4-(3-ethynylphenylamino)-6-(5-((2-(methylsulfonyl)ethyl)aminomethyl)furan-2-yl)quinazoline

Conditions

Conditions	Yield
Stage #1: 2-(methylsulfonyl)ethylamine hydrochloride With sodium sulfate; triethylamine In methanol at 0℃; for 0.333333h; Stage #2: 4-(3-ethynyl-phenylamino)-6-(5-formylfuran-2-yl)quinazoline With formic acid; sodium cyanoborohydride In tetrahydrofuran; methanol; N,N-dimethyl-formamide for 2h; pH=5 - 6;	79.7%

: 1421356-86-6
4-(3-chloro-4-fluorophenylamino)-6-(5-formylfuran-2-yl)quinazoline

: 104458-24-4
2-(methylsulfonyl)ethylamine hydrochloride

: 4-(3-chloro-4-fluorophenylamino)-6-(5-((2-(methylsulfonyl)ethyl)aminomethyl)furan-2-yl)quinazoline

Conditions

Conditions	Yield
Stage #1: 2-(methylsulfonyl)ethylamine hydrochloride With sodium sulfate; triethylamine In methanol at 0℃; for 0.333333h; Stage #2: N-(3-chloro-4-fluorophenyl)-6-(5-formyl-2-furyl)-4-quinazolinamine With formic acid; sodium cyanoborohydride In tetrahydrofuran; methanol; N,N-dimethyl-formamide for 2h; pH=5 - 6;	78.1%

: 104458-24-4
2-(methylsulfonyl)ethylamine hydrochloride

: 76-05-1
trifluoroacetic acid

: 897732-57-9
(2-methanesulfonyl-ethyl)-(6-methyl-5-nitro-pyridin-2-yl)-amine trifluoroacetate

Conditions

Conditions	Yield
Stage #1: 6-fluoro-2-methyl-3-nitro-pyridine; 2-(methylsulfonyl)ethylamine hydrochloride With potassium carbonate In tetrahydrofuran at 20 - 60℃; for 100h; Stage #2: trifluoroacetic acid	78%

: 1637438-04-0
(S)-4-(4-((2-hydroxy-1-phenylethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-3-methoxybenzaldehyde

: 104458-24-4
2-(methylsulfonyl)ethylamine hydrochloride

: (S)-2-((6-(2-methoxy-4-(((2-(methylsulfonyl)ethyl)amino)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-phenylethan-1-ol

Conditions

Conditions	Yield
Stage #1: 2-(methylsulfonyl)ethylamine hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.5h; Stage #2: (S)-4-(4-((2-hydroxy-1-phenylethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-3-methoxybenzaldehyde In dichloromethane at 20℃; for 6h; Stage #3: With sodium tetrahydroborate In methanol for 3h;	77%

: 650626-61-2
4-((E)-{[1-(4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]hydrazono}methyl)benzoic acid

: 104458-24-4
2-(methylsulfonyl)ethylamine hydrochloride

: 4-((E)-{[1-(4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]hydrazono}methyl)-N-[2-(methylsulfonyl)ethyl]benzamide

Conditions

Conditions	Yield
With diethyl cyanophosphonate; triethylamine In DMF (N,N-dimethyl-formamide) at 20℃; for 16h;	76%

2-Aminoethylmethylsulfone hydrochloride Specification

The Ethanamine,2-(methylsulfonyl)-, hydrochloride (1:1), with CAS registry number 104458-24-4, belongs to the following product category: Intermediate of lapatinib ditosylate. It has the systematic name of 2-(methylsulfonyl)ethanamine hydrochloride (1:1). And the chemical formula of this chemical is C₃H₉NO₂S^.HCl.

Physical properties of Ethanamine,2-(methylsulfonyl)-, hydrochloride (1:1): (1)# of Rule of 5 Violations: 0; (2)ACD/BCF (pH 5.5): 1; (3)ACD/BCF (pH 7.4): 1; (4)ACD/KOC (pH 5.5): 1; (5)ACD/KOC (pH 7.4): 2; (6)#H bond acceptors: 3; (7)#H bond donors: 2; (8)#Freely Rotating Bonds: 3; (9)Polar Surface Area: 68.54 Å²; (10)Enthalpy of Vaporization: 57.92 kJ/mol; (11)Vapour Pressure: 0.000163 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES: Cl.CS(=O)(=O)CCN
(2)InChI: InChI=1/C3H9NO2S.ClH/c1-7(5,6)3-2-4;/h2-4H2,1H3;1H
(3)InChIKey: AMYYUKGKCJKCBI-UHFFFAOYAR
(4)Std. InChI: InChI=1S/C3H9NO2S.ClH/c1-7(5,6)3-2-4;/h2-4H2,1H3;1H
(5)Std. InChIKey: AMYYUKGKCJKCBI-UHFFFAOYSA-N

Product Name

2-Aminoethylmethylsulfone hydrochloride

Synthetic route

2-Aminoethylmethylsulfone hydrochloride Specification

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