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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

2-Chloro-4,5-difluorobenzoic acid

Cas:110877-64-0

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2-Chloride-4,5-Difluoride Benzoic Acids supplier in China

Cas:110877-64-0

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res

2-Chloro-4,5-difluorobenzoic acid

Cas:110877-64-0

Min.Order:10 Kilogram

FOB Price: $95.0 / 100.0

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 2-chloro-4,5-difluorobenzoic acid

Cas:110877-64-0

Min.Order:1

Negotiable

Type:Other

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-Chloro-4,5-difluorobenzoic acid

Cas:110877-64-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

2-Chloro-4, 5-Difluorobenzoic Acid CAS 110877-64-0

Cas:110877-64-0

Min.Order:1 Kilogram

FOB Price: $10.0 / 16.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 110877-64-0 with best quality

Cas:110877-64-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after the dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available &diam

2-Chloro-4,5-difluorobenzoic acid CAS110877-64-0

Cas:110877-64-0

Min.Order:1 Kilogram

FOB Price: $7.0 / 10.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Benzoicacid, 2-chloro-4,5-difluoro- 110877-64-0

Cas:110877-64-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: 2-Chloro-4,5-difluorobenzoic acid Synonyms: RARECHEM AL BO 1000;TIMTEC-BB SBB003616;2-CHLORO-4,5-DIFLUOROBENZOIC ACID;2-CHLORO-4 5-DIFLUOROBENZENE ACID 98%;2-Chloro-4,5-difluorobenzoic acid, 99+%;2-Chloro-4,5-difluorobenzoic acid

2-Chloro-4,5-difluorobenzoic acid

Cas:110877-64-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

2-Chloro-4,5-difluorobenzoic acid CAS:110877-64-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high qualit

2-Chloro-4,5-difluorobenzoic acid CAS:110877-64-0

Cas:110877-64-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Benzoicacid, 2-chloro-4,5-difluoro-

Cas:110877-64-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,

2-Chloro-4,5-difluorobenzoic acid CAS NO.110877-64-0

Cas:110877-64-0

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Benzoicacid, 2-chloro-4,5-difluoro-

Cas:110877-64-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2-chloride-4,5-difluoride benzoic acids

Cas:110877-64-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We have s

2-Chloro-4,5-difluorobenzoic acid

Cas:110877-64-0

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

CAS110877-64-0 2-Chloro-4,5-difluorobenzoic acid

Cas:110877-64-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

2-Chloro-4,5-difluorobenzoic acid

Cas:110877-64-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Benzoicacid, 2-chloro-4,5-difluoro-

Cas:110877-64-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

2-Chloro-4,5-difluorobenzoic acid

Cas:110877-64-0

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 2-Chloride-4,5-Difluoride Benzoic Acids

Cas:110877-64-0

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

2-Chloro-4,5-difluorobenzoicacid

Cas:110877-64-0

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so

2-Chloro-4,5-difluorobenzoic acid

Cas:110877-64-0

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

2-Chloro-4,5-difluorobenzoic acid

Cas:110877-64-0

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

2-Chloro-4,5-difluorobenzoic acid

Cas:110877-64-0

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

2-Chloro-4,5-difluorobenzoic acid

Cas:110877-64-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Hot Sales 2-Chloro-4,5-difluorobenzoic acid CAS NO.110877-64-0 CAS NO.110877-64-0

Cas:110877-64-0

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

2-Chloro-4,5-difluorobenzoic acid

Cas:110877-64-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

2-chloro-4,5-difluorobenzoic Acid

Cas:110877-64-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

2-Chloro-4,5-difluorobenzoic acid

Cas:110877-64-0

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Synthetic route

2'-chloro-4',5'-difluoroacetophenone
121872-94-4

2'-chloro-4',5'-difluoroacetophenone

2-chloro-4,5-difluorobenzoic acid
110877-64-0

2-chloro-4,5-difluorobenzoic acid

Conditions
ConditionsYield
With sodium hypochlorite Oxidation;90%
With hydrogenchloride; sodium hypochlorite In dichloromethane85.1%
With hydrogenchloride; sodium hypochlorite In dichloromethane85.1%
With sodium hypochlorite for 6h; Heating;80%
With hydrogenchloride; sodium hydroxide; sodium hypobromide; bromine; sodium hydrogensulfite In 1,4-dioxane; dichloromethane; water
2-chloro-5-fluoro-4-nitrobenzoic acid

2-chloro-5-fluoro-4-nitrobenzoic acid

4-chlorosulfonyl chloride

4-chlorosulfonyl chloride

2-chloro-4,5-difluorobenzoic acid
110877-64-0

2-chloro-4,5-difluorobenzoic acid

Conditions
ConditionsYield
With KF; benzenesulfonyl chloride In sulfolane; thionyl chloride75%
2-chloro-4,5-difluoro-α-chloroacetophenone
133117-00-7

2-chloro-4,5-difluoro-α-chloroacetophenone

2-chloro-4,5-difluorobenzoic acid
110877-64-0

2-chloro-4,5-difluorobenzoic acid

Conditions
ConditionsYield
With sodium hypochlorite Oxidation;
4-chloro-1,2-difluorobenzene
696-02-6

4-chloro-1,2-difluorobenzene

2-chloro-4,5-difluorobenzoic acid
110877-64-0

2-chloro-4,5-difluorobenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 80 percent / AlCl3
2: 90 percent / 5 percent NaOCl
View Scheme
Multi-step reaction with 2 steps
1: 95 percent / AlCl3
2: 5 percent NaOCl
View Scheme
Multi-step reaction with 2 steps
1: 75 percent / AlCl3 / 9 h / 60 °C
2: 80 percent / NaOCl / 6 h / Heating
View Scheme
2-fluoro-5-chloronitrobenzene
345-18-6

2-fluoro-5-chloronitrobenzene

2-chloro-4,5-difluorobenzoic acid
110877-64-0

2-chloro-4,5-difluorobenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: H2 / 5 percent Pt/C / 1,2-dimethoxy-ethane / 24 h / 2585.74 Torr
2: BF3*Et2O; t-BuONO / 1,2-dimethoxy-ethane / 1 h / -5 °C
3: 49 percent / 0.5 h / 170 °C
4: 80 percent / AlCl3
5: 90 percent / 5 percent NaOCl
View Scheme
Multi-step reaction with 5 steps
1: H2 / 5 percent Pt/C / 1,2-dimethoxy-ethane / 24 h / 2585.74 Torr
2: BF3*Et2O; t-BuONO / 1,2-dimethoxy-ethane / 1 h / -5 °C
3: 49 percent / 0.5 h / 170 °C
4: 95 percent / AlCl3
5: 5 percent NaOCl
View Scheme
5-chloro-2-fluoroaniline
2106-05-0

5-chloro-2-fluoroaniline

2-chloro-4,5-difluorobenzoic acid
110877-64-0

2-chloro-4,5-difluorobenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: BF3*Et2O; t-BuONO / 1,2-dimethoxy-ethane / 1 h / -5 °C
2: 49 percent / 0.5 h / 170 °C
3: 80 percent / AlCl3
4: 90 percent / 5 percent NaOCl
View Scheme
Multi-step reaction with 4 steps
1: BF3*Et2O; t-BuONO / 1,2-dimethoxy-ethane / 1 h / -5 °C
2: 49 percent / 0.5 h / 170 °C
3: 95 percent / AlCl3
4: 5 percent NaOCl
View Scheme
2,5-dichloronitrobenzene
89-61-2

2,5-dichloronitrobenzene

potassium-compound of 1-<4-hydroxy-phenyl>-ethanone

potassium-compound of 1-<4-hydroxy-phenyl>-ethanone

2-chloro-4,5-difluorobenzoic acid
110877-64-0

2-chloro-4,5-difluorobenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 52 percent / KF; 18-crown-6 / tetrahydrothiophene 1,1-dioxide / 32 h / 180 °C
2: H2 / 5 percent Pt/C / 1,2-dimethoxy-ethane / 24 h / 2585.74 Torr
3: BF3*Et2O; t-BuONO / 1,2-dimethoxy-ethane / 1 h / -5 °C
4: 49 percent / 0.5 h / 170 °C
5: 80 percent / AlCl3
6: 90 percent / 5 percent NaOCl
View Scheme
Multi-step reaction with 6 steps
1: 52 percent / KF; 18-crown-6 / tetrahydrothiophene 1,1-dioxide / 32 h / 180 °C
2: H2 / 5 percent Pt/C / 1,2-dimethoxy-ethane / 24 h / 2585.74 Torr
3: BF3*Et2O; t-BuONO / 1,2-dimethoxy-ethane / 1 h / -5 °C
4: 49 percent / 0.5 h / 170 °C
5: 95 percent / AlCl3
6: 5 percent NaOCl
View Scheme
2-Fluoro-5-chlorophenyldiazonium tetrafluoroborate

2-Fluoro-5-chlorophenyldiazonium tetrafluoroborate

2-chloro-4,5-difluorobenzoic acid
110877-64-0

2-chloro-4,5-difluorobenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 49 percent / 0.5 h / 170 °C
2: 80 percent / AlCl3
3: 90 percent / 5 percent NaOCl
View Scheme
Multi-step reaction with 3 steps
1: 49 percent / 0.5 h / 170 °C
2: 95 percent / AlCl3
3: 5 percent NaOCl
View Scheme
ortho-difluorobenzene
367-11-3

ortho-difluorobenzene

2-chloro-4,5-difluorobenzoic acid
110877-64-0

2-chloro-4,5-difluorobenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 90 percent / FeCl3, Cl2 / 3 h / 50 °C
2: 75 percent / AlCl3 / 9 h / 60 °C
3: 80 percent / NaOCl / 6 h / Heating
View Scheme
2-chloro-4,5-difluorobenzotrichloride
136364-59-5

2-chloro-4,5-difluorobenzotrichloride

2-chloro-4,5-difluorobenzoic acid
110877-64-0

2-chloro-4,5-difluorobenzoic acid

Conditions
ConditionsYield
With sulfuric acid
With sulfuric acid
ammonium persulfate

ammonium persulfate

2-chloro-4,5-difluorobenzophenone

2-chloro-4,5-difluorobenzophenone

2-chloro-4,5-difluorobenzoic acid
110877-64-0

2-chloro-4,5-difluorobenzoic acid

Conditions
ConditionsYield
With sulfuric acid In water; acetic acid
2-chloro-4,5-difluoro-α,α-dichloroacetophenone

2-chloro-4,5-difluoro-α,α-dichloroacetophenone

sodium disulfite

sodium disulfite

water
7732-18-5

water

2-chloro-4,5-difluorobenzoic acid
110877-64-0

2-chloro-4,5-difluorobenzoic acid

Conditions
ConditionsYield
With hydrogenchloride; sodium hydroxide; bromine In sodium hypobromide
sodium disulfite

sodium disulfite

2-chloro-4,5-difluoro-α-chloroacetophenone
133117-00-7

2-chloro-4,5-difluoro-α-chloroacetophenone

2-chloro-4,5-difluorobenzoic acid
110877-64-0

2-chloro-4,5-difluorobenzoic acid

Conditions
ConditionsYield
With hydrogenchloride In sodium hypobromide
2-chloro-4,5-difluoro-α,α-dichloroacetophenone

2-chloro-4,5-difluoro-α,α-dichloroacetophenone

sodium disulfite

sodium disulfite

2-chloro-4,5-difluorobenzoic acid
110877-64-0

2-chloro-4,5-difluorobenzoic acid

Conditions
ConditionsYield
With hydrogenchloride In sodium hypochlorite
tert.-butylnitrite
540-80-7

tert.-butylnitrite

2-amino-4,5-difluorobenzoic acid
83506-93-8

2-amino-4,5-difluorobenzoic acid

2-chloro-4,5-difluorobenzoic acid
110877-64-0

2-chloro-4,5-difluorobenzoic acid

Conditions
ConditionsYield
With hydrogenchloride In water; acetonitrile
2-amino-4,5-difluorobenzoic acid
83506-93-8

2-amino-4,5-difluorobenzoic acid

2-chloro-4,5-difluorobenzoic acid
110877-64-0

2-chloro-4,5-difluorobenzoic acid

Conditions
ConditionsYield
With sodium nitrate; copper(l) chloride In hydrogenchloride; water
2-chloro-4,5-difluorobenzoic acid
110877-64-0

2-chloro-4,5-difluorobenzoic acid

2-chloro-4,5-difluorobenzoyl chloride
121872-95-5

2-chloro-4,5-difluorobenzoyl chloride

Conditions
ConditionsYield
With pyridine; thionyl chloride In toluene92.1%
With N,N-dimethyl-formamide In dichloromethane for 3h; Ambient temperature;
With thionyl chloride; N,N-dimethyl-formamide for 2h; Heating;
methanol
67-56-1

methanol

2-chloro-4,5-difluorobenzoic acid
110877-64-0

2-chloro-4,5-difluorobenzoic acid

2-Chloro-4,5-difluorobenzoic acid methyl ester
128800-36-2

2-Chloro-4,5-difluorobenzoic acid methyl ester

Conditions
ConditionsYield
With sulfuric acid at 60℃; for 48h;86.6%
With acetyl chloride at 0℃;84%
With acetyl chloride at 20℃; Cooling with ice;
With acetyl chloride for 65h; Reflux;
2-chloro-4,5-difluorobenzoic acid
110877-64-0

2-chloro-4,5-difluorobenzoic acid

acetyl chloride
75-36-5

acetyl chloride

2-Chloro-4,5-difluorobenzoic acid methyl ester
128800-36-2

2-Chloro-4,5-difluorobenzoic acid methyl ester

Conditions
ConditionsYield
In methanol84%
2-chloro-4,5-difluorobenzoic acid
110877-64-0

2-chloro-4,5-difluorobenzoic acid

3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-ylamine
19541-96-9

3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-ylamine

4,5-difluoro-2-[[3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-yl]amino]benzoic acid
364727-90-2

4,5-difluoro-2-[[3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-yl]amino]benzoic acid

Conditions
ConditionsYield
With potassium carbonate; acetic acid In N,N-dimethyl-formamide81%
With potassium carbonate; acetic acid In N,N-dimethyl-formamide81%
2-chloro-4,5-difluorobenzoic acid
110877-64-0

2-chloro-4,5-difluorobenzoic acid

metronidazole
443-48-1

metronidazole

2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl 2-chloro-4,5-difluorobenzoate
1403815-92-8

2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl 2-chloro-4,5-difluorobenzoate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃;80%
3-methyl-1-(6-methylpyridin-2-yl)-1H-pyrazol-5-amine
364728-13-2

3-methyl-1-(6-methylpyridin-2-yl)-1H-pyrazol-5-amine

2-chloro-4,5-difluorobenzoic acid
110877-64-0

2-chloro-4,5-difluorobenzoic acid

A

4-chloro-6,7-difluoro-3-methyl-1-(6-methyl-2-pyridinyl)-1H-pyrazolo[3,4-b]quinoline
364728-21-2

4-chloro-6,7-difluoro-3-methyl-1-(6-methyl-2-pyridinyl)-1H-pyrazolo[3,4-b]quinoline

B

4,5-difluoro-2-[[3-methyl-1-(6-methyl-2-pyridinyl)-1H-pyrazol-5-yl]amino]benzoic acid
364728-20-1

4,5-difluoro-2-[[3-methyl-1-(6-methyl-2-pyridinyl)-1H-pyrazol-5-yl]amino]benzoic acid

Conditions
ConditionsYield
With hydrogenchloride; potassium carbonate In N,N-dimethyl-formamideA 39%
B 79%
2-chloro-4,5-difluorobenzoic acid
110877-64-0

2-chloro-4,5-difluorobenzoic acid

4-amino-5-(3-pyridyl)-4H-1,2,4-triazole-3-thiol
78027-00-6

4-amino-5-(3-pyridyl)-4H-1,2,4-triazole-3-thiol

6-(2-chloro-4,5-difluorophenyl)-3-(pyridin-3-yl)[1,2,4]-triazolo[3,4-b][1,3,4]thiadiazole

6-(2-chloro-4,5-difluorophenyl)-3-(pyridin-3-yl)[1,2,4]-triazolo[3,4-b][1,3,4]thiadiazole

Conditions
ConditionsYield
With trichlorophosphate for 6h; Reflux;79%
2-chloro-4,5-difluorobenzoic acid
110877-64-0

2-chloro-4,5-difluorobenzoic acid

phenylmethanethiol
100-53-8

phenylmethanethiol

4-(benzylthio)-2-chloro-5-fluorobenzoic acid

4-(benzylthio)-2-chloro-5-fluorobenzoic acid

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 70℃; for 6h;79%
2-chloro-4,5-difluorobenzoic acid
110877-64-0

2-chloro-4,5-difluorobenzoic acid

2-chloro-4,5-difluorobenzamide
296274-32-3

2-chloro-4,5-difluorobenzamide

Conditions
ConditionsYield
Stage #1: 2-chloro-4,5-difluorobenzoic acid With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 1h;
Stage #2: With ammonia In water; N,N-dimethyl-formamide at 0 - 20℃; for 0.5h;
76%
Stage #1: 2-chloro-4,5-difluorobenzoic acid With thionyl chloride In toluene at 60℃; for 1.5h; Heating / reflux;
Stage #2: With pyridine In toluene at 60℃; for 1.5h;
Stage #3: With ammonia In toluene at 20 - 35℃;
2-chloro-4,5-difluorobenzoic acid
110877-64-0

2-chloro-4,5-difluorobenzoic acid

benzylamine
100-46-9

benzylamine

N-benzyl-2-chloro-4,5-difluorobenzamide
710981-36-5

N-benzyl-2-chloro-4,5-difluorobenzamide

Conditions
ConditionsYield
Stage #1: 2-chloro-4,5-difluorobenzoic acid With triethylamine; isobutyl chloroformate In dichloromethane for 0.25h; Inert atmosphere; Schlenk technique;
Stage #2: benzylamine In dichloromethane at 0℃;
76%
2-chloro-4,5-difluorobenzoic acid
110877-64-0

2-chloro-4,5-difluorobenzoic acid

4-amino-3-(2-furyl)-5-mercapto[4H]-1,2,4-triazole
80809-38-7

4-amino-3-(2-furyl)-5-mercapto[4H]-1,2,4-triazole

6-(2-chloro-4,5-difluorophenyl)-3-(furan-2-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

6-(2-chloro-4,5-difluorophenyl)-3-(furan-2-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

Conditions
ConditionsYield
With trichlorophosphate Reflux;75%
4-amino-5-(pyridin-4-yl)-4H-1,2,4-triazole-3-thiol
36209-51-5

4-amino-5-(pyridin-4-yl)-4H-1,2,4-triazole-3-thiol

2-chloro-4,5-difluorobenzoic acid
110877-64-0

2-chloro-4,5-difluorobenzoic acid

6-(2-chloro-4,5-difluorophenyl)-3-(pyridin-4-yl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
1607018-29-0

6-(2-chloro-4,5-difluorophenyl)-3-(pyridin-4-yl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

Conditions
ConditionsYield
With trichlorophosphate Reflux;74%
2-Amino-4,6-dimethylpyridine
5407-87-4

2-Amino-4,6-dimethylpyridine

2-chloro-4,5-difluorobenzoic acid
110877-64-0

2-chloro-4,5-difluorobenzoic acid

N-(4,6-dimethylpyridin-2-yl)-2-chloro-4,5-difluorobenzamide

N-(4,6-dimethylpyridin-2-yl)-2-chloro-4,5-difluorobenzamide

Conditions
ConditionsYield
With O-phenyl phosphorodichloridate; triethylamine In 1,2-dichloro-ethane at 20℃; for 24h;72%
3-ethyl-1-(2-pyridinyl)-1H-pyrazol-5-ylamine
364728-11-0

3-ethyl-1-(2-pyridinyl)-1H-pyrazol-5-ylamine

2-chloro-4,5-difluorobenzoic acid
110877-64-0

2-chloro-4,5-difluorobenzoic acid

A

4-chloro-3-ethyl-6,7-difluoro-1-(2-pyridinyl)-1H-pyrazolo[3,4-b]quinoline
364727-14-0

4-chloro-3-ethyl-6,7-difluoro-1-(2-pyridinyl)-1H-pyrazolo[3,4-b]quinoline

B

4,5-difluoro-2-[[3-ethyl-1-(2-pyridinyl)-1H-pyrazol-5-yl]amino]benzoic acid
364728-18-7

4,5-difluoro-2-[[3-ethyl-1-(2-pyridinyl)-1H-pyrazol-5-yl]amino]benzoic acid

Conditions
ConditionsYield
With hydrogenchloride; potassium carbonate In N,N-dimethyl-formamideA 50%
B 66%
ethanamine hydrochloride
557-66-4

ethanamine hydrochloride

2-chloro-4,5-difluorobenzoic acid
110877-64-0

2-chloro-4,5-difluorobenzoic acid

2-(ethylamino)-4,5-difluorobenzoic acid

2-(ethylamino)-4,5-difluorobenzoic acid

Conditions
ConditionsYield
With potassium phosphate; copper(l) iodide In N,N-dimethyl-formamide at 140℃; for 1.5h; Microwave irradiation;65%
3-methyl-1-(3-pyridinyl)-1H-pyrazol-5-ylamine dihydrochloride

3-methyl-1-(3-pyridinyl)-1H-pyrazol-5-ylamine dihydrochloride

2-chloro-4,5-difluorobenzoic acid
110877-64-0

2-chloro-4,5-difluorobenzoic acid

A

4-chloro-6,7-difluoro-3-methyl-1-(3-pyridinyl)-1H-pyrazolo[3,4-b]quinoline
364727-16-2

4-chloro-6,7-difluoro-3-methyl-1-(3-pyridinyl)-1H-pyrazolo[3,4-b]quinoline

B

4,5-difluoro-2-[[3-methyl-1-(3-pyridinyl)-1H-pyrazol-5-yl]amino]benzoic acid

4,5-difluoro-2-[[3-methyl-1-(3-pyridinyl)-1H-pyrazol-5-yl]amino]benzoic acid

Conditions
ConditionsYield
With hydrogenchloride; potassium carbonate In N,N-dimethyl-formamideA 8%
B 63%
2-chloro-4,5-difluorobenzoic acid
110877-64-0

2-chloro-4,5-difluorobenzoic acid

1,1,1,3,3,3-hexamethyl-disilazane
999-97-3

1,1,1,3,3,3-hexamethyl-disilazane

trimethylsilyl 2-chloro-4,5-difluorobenzoate

trimethylsilyl 2-chloro-4,5-difluorobenzoate

Conditions
ConditionsYield
With iodine In neat (no solvent) at 20℃; for 96h; Green chemistry;62%
1-(tert-butyl)-2-iodobenzene
62171-59-9

1-(tert-butyl)-2-iodobenzene

2-chloro-4,5-difluorobenzoic acid
110877-64-0

2-chloro-4,5-difluorobenzoic acid

C16H14F2

C16H14F2

Conditions
ConditionsYield
With tetrabutyl-ammonium chloride; palladium diacetate; potassium carbonate; Tri(p-tolyl)phosphine In N,N-dimethyl-formamide at 140℃; for 12h; Schlenk technique; Inert atmosphere;58%
2-chloro-4,5-difluorobenzoic acid
110877-64-0

2-chloro-4,5-difluorobenzoic acid

2-bromocyclooctyl 2-chloro-4,5-difluorobenzoate

2-bromocyclooctyl 2-chloro-4,5-difluorobenzoate

Conditions
ConditionsYield
With N-Bromosuccinimide; 5,6-difluoro-2-(1-phenylethyl)benzo[d][1,2]selenazol-3(2H)-one In dichloromethane at 20℃; for 8h;56%
2-chloro-4,5-difluorobenzoic acid
110877-64-0

2-chloro-4,5-difluorobenzoic acid

1-(2-pyridinyl)-1H-pyrazol-5-ylamine
89977-46-8

1-(2-pyridinyl)-1H-pyrazol-5-ylamine

4,5-difluoro-2-[[1-(2-pyridinyl)-1H-pyrazol-5-yl]amino]benzoic acid
364728-10-9

4,5-difluoro-2-[[1-(2-pyridinyl)-1H-pyrazol-5-yl]amino]benzoic acid

Conditions
ConditionsYield
With hydrogenchloride; potassium carbonate In N,N-dimethyl-formamide55%
methanol
67-56-1

methanol

dysprosium(III) nitrate hexahydrate

dysprosium(III) nitrate hexahydrate

N-Methyldiethanolamine
105-59-9

N-Methyldiethanolamine

chromium(III) chloride hexahydrate

chromium(III) chloride hexahydrate

2-chloro-4,5-difluorobenzoic acid
110877-64-0

2-chloro-4,5-difluorobenzoic acid

2Cr(3+)*2Dy(3+)*1.4CH3O(1-)*0.6HO(1-)*4C7H2ClF2O2(1-)*2C5H11NO2(2-)*2NO3(1-)*0.6CH4O

2Cr(3+)*2Dy(3+)*1.4CH3O(1-)*0.6HO(1-)*4C7H2ClF2O2(1-)*2C5H11NO2(2-)*2NO3(1-)*0.6CH4O

Conditions
ConditionsYield
Stage #1: dysprosium(III) nitrate hexahydrate; N-Methyldiethanolamine; chromium(III) chloride hexahydrate; 2-chloro-4,5-difluorobenzoic acid With triethylamine In acetonitrile for 2h;
Stage #2: methanol In diethyl ether
49%
methanol
67-56-1

methanol

terbium(III) nitrate hexahydrate

terbium(III) nitrate hexahydrate

N-Methyldiethanolamine
105-59-9

N-Methyldiethanolamine

chromium(III) chloride hexahydrate

chromium(III) chloride hexahydrate

2-chloro-4,5-difluorobenzoic acid
110877-64-0

2-chloro-4,5-difluorobenzoic acid

2Cr(3+)*2Tb(3+)*0.8CH3O(1-)*1.2HO(1-)*4C7H2ClF2O2(1-)*2C5H11NO2(2-)*2NO3(1-)*1.2CH4O

2Cr(3+)*2Tb(3+)*0.8CH3O(1-)*1.2HO(1-)*4C7H2ClF2O2(1-)*2C5H11NO2(2-)*2NO3(1-)*1.2CH4O

Conditions
ConditionsYield
Stage #1: terbium(III) nitrate hexahydrate; N-Methyldiethanolamine; chromium(III) chloride hexahydrate; 2-chloro-4,5-difluorobenzoic acid With triethylamine In acetonitrile for 2h;
Stage #2: methanol In diethyl ether
42%
methanol
67-56-1

methanol

holmium(III) nitrate hexahydrate

holmium(III) nitrate hexahydrate

N-Methyldiethanolamine
105-59-9

N-Methyldiethanolamine

chromium(III) chloride hexahydrate

chromium(III) chloride hexahydrate

2-chloro-4,5-difluorobenzoic acid
110877-64-0

2-chloro-4,5-difluorobenzoic acid

2Cr(3+)*2Ho(3+)*1.16CH3O(1-)*0.84HO(1-)*4C7H2ClF2O2(1-)*2C5H11NO2(2-)*2NO3(1-)*0.84CH4O

2Cr(3+)*2Ho(3+)*1.16CH3O(1-)*0.84HO(1-)*4C7H2ClF2O2(1-)*2C5H11NO2(2-)*2NO3(1-)*0.84CH4O

Conditions
ConditionsYield
Stage #1: holmium(III) nitrate hexahydrate; N-Methyldiethanolamine; chromium(III) chloride hexahydrate; 2-chloro-4,5-difluorobenzoic acid With triethylamine In acetonitrile for 2h;
Stage #2: methanol In diethyl ether
39%

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