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Shanghai Systeam Biochem CO.,ltd

(S)-5-BOC-5-AZASPIRO[2.4]HEPTANE-6-CARBOXYLIC ACID(We are one of a few suppliers that can offer custom synthesis service of this product) We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and cont

(S)-5-BOC-5-AZASPIRO[2.4]HEPTANE-6-CARBOXYLIC ACID

Cas:1129634-44-1

Min.Order:500 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------

High purity 1129634-44-1 (S)-5-BOC-5-AZASPIRO[2.4]HEPTANE-6-CARBOXYLIC ACID

Cas:1129634-44-1

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

(S)-5-(tert-Butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylic acid CAS No.:1129634-44-1 Name: (S)-5-(tert-Butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylic acid Molecular Structure Molecular Formula: C12H19

Henan Allgreen Chemical Co.,Ltd

(S)-5-BOC-5-AZASPIRO[2.4]HEPTANE-6-CARBOXYLIC ACID Basic information Product Name: (S)-5-BOC-5-AZASPIRO[2.4]HEPTANE-6-CARBOXYLIC ACID Synonyms: (S)-5-BOC-5-AZASPIRO

(S)-5-BOC-5-AZASPIRO[2.4]HEPTANE-6-CARBOXYLIC ACID

Cas:1129634-44-1

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

(S)-5-BOC-5-AZASPIRO[2.4]HEPTANE-6-CARBOXYLIC ACID

Cas:1129634-44-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

(S)-5-(tert-Butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylic acid

Cas:1129634-44-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(S)-5-(tert-Butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylic acid

Cas:1129634-44-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/947.html Product Name (S)-5-(tert-Butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylic acid

(S)-5-(tert-Butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylic acid

Cas:1129634-44-1

Min.Order:1 Gram

FOB Price: $66.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Competitive Price High Quality Fast Delivery custom-made Welcome to Henan Tianfu Chemical Co., Ltd. website. Our company engages in Sodium Tripolyphosphate (STPP) and Sodium Hexametabphosphate (SHMP) production; development of noble me

(S)-5-BOC-5-AZASPIRO[2.4]HEPTANE-6-CARBOXYLIC ACID

Cas:1129634-44-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 1129634-44-1 with competitive price

Cas:1129634-44-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Ledipasvir intermediate 2

Cas:1129634-44-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

(S)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylic acidCAS1129634-44-1

Cas:1129634-44-1

Min.Order:1 Kilogram

FOB Price: $10.0 / 20.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name: (S)-5-Boc-5-Azaspiro[2.4]heptane-6-carboxylic acid Synonyms: Ledipasvir Intermediate-3 CAS:1129634-44-1 Appearance: white powder Storage:Store in cool and dry place, away from sun light. Package: 25kgs/drum Application: Pharmaceutical Inte

(S)-5-Boc-5-Azaspiro[2.4]heptane-6-carboxylic acid

Cas:1129634-44-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

high quality 1129634-44-1 Ledipasvir side chain with best price

Cas:1129634-44-1

Min.Order:10 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

(S)-5-BOC-5-AZASPIRO[2.4]HEPTANE-6-CARBOXYLIC ACID 1129634-44-1

Cas:1129634-44-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac

(S)-5-(tert-Butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylic acid

Cas:1129634-44-1

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

(S)-5-BOC-5-AZASPIRO[2.4]HEPTANE-6-CARBOXYLIC ACID

Cas:1129634-44-1

Min.Order:1 Kilogram

FOB Price: $42.0 / 56.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

(S)-5-BOC-5-AZASPIRO[2.4]HEPTANE-6-CARBOXYLIC ACID CAS:1129634-44-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializ

(S)-5-BOC-5-AZASPIRO[2.4]HEPTANE-6-CARBOXYLIC ACID CAS:1129634-44-1

Cas:1129634-44-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

(S)-5-BOC-5-AZASPIRO[2.4]HEPTANE-6-CARBOXYLIC ACID

Cas:1129634-44-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

We are concentrating on the R&D and technical service of APIs and pharmaceutical intermediates Application:Pharmaceutical intermediate Port:Chinese main port

Ledipasvir intermediate 2

Cas:1129634-44-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

(S)-5-BOC-5-AZASPIRO[2.4]HEPTANE-6-CARBOXYLIC ACID

Cas:1129634-44-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and qua

(S)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylic acid

Cas:1129634-44-1

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

(S)-5-BOC-5-AZASPIRO[2.4]HEPTANE-6-CARBOXYLIC ACID

Cas:1129634-44-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

(S)-5-BOC-5-AZASPIRO[2.4]HEPTANE-6-CARBOXYLIC ACID

Cas:1129634-44-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(S)-5-(tert-butoxycarbonyl)- 5-azaspiro[2.4]heptane-6-carboxylic acid

Cas:1129634-44-1

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Saiwante (shanghai) New Material Technology Co., Ltd.

Boiling Point: 377.4±35.0 °C(Predicted) PKA: 4.04±0.20(Predicted) PSA: 66.84000 Density: 1.23±0.1 g/cm3(Predicted) LogP: 1.79850 Storage Temp.: 2-8°C Purity/Quality: 99% Appearance:white powder Storage:cool and dry

1129634-44-1(S)-5-BOC-5-AZASPIRO[2.4]HEPTANE-6-CARBOXYLIC ACID

Cas:1129634-44-1

Min.Order:1 Gram

FOB Price: $6.0

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

(S)-5-BOC-5-AZASPIRO[2.4]HEPTANE-6-CARBOXYLIC ACID

Cas:1129634-44-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

(S)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylic acid

Cas:1129634-44-1

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

(S)-5-BOC-5-AZASPIRO[2.4]HEPTANE-6-CARBOXYLIC ACID

Cas:1129634-44-1

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

(S)-5-BOC-5-AZASPIRO[2.4]HEPTANE-6-CARBOXYLIC ACIDAppearance:white powder Storage:Protected from light, stored hermetically and in a dry place Package:according to customers' requirements Application:Pharmaceutical Transportation:By air(EMS or EUB or

(S)-5-BOC-5-AZASPIRO[2.4]HEPTANE-6-CARBOXYLIC ACID

Cas:1129634-44-1

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Synthetic route

(6S)-5-tert-butyl 6-methyl 5-azaspiro[2.4]heptane-5,6-dicarboxylate
1129634-43-0

(6S)-5-tert-butyl 6-methyl 5-azaspiro[2.4]heptane-5,6-dicarboxylate

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

Conditions
ConditionsYield
Stage #1: (6S)-5-tert-butyl 6-methyl 5-azaspiro[2.4]heptane-5,6-dicarboxylate With lithium hydroxide monohydrate; water In ethanol at 20℃; for 20h;
Stage #2: With hydrogenchloride In water pH=2; Ice bath;
100%
With water; sodium hydroxide In ethanol for 24h;34%
With water; lithium hydroxide In tetrahydrofuran; methanol at 60℃; for 16h;
With water; lithium hydroxide In tetrahydrofuran at 20℃;2.4 g
(6S)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylic acid R-α-methylbenzylamine salt

(6S)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylic acid R-α-methylbenzylamine salt

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

Conditions
ConditionsYield
With hydrogenchloride In Isopropyl acetate; water at 0℃; pH=3 - 4;100%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(S)-5-azaspiro[2.4]heptane-6-carboxylic acid D-di-p-methylbenzoyltartrate

(S)-5-azaspiro[2.4]heptane-6-carboxylic acid D-di-p-methylbenzoyltartrate

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

Conditions
ConditionsYield
Stage #1: (S)-5-azaspiro[2.4]heptane-6-carboxylic acid D-di-p-methylbenzoyltartrate With hydrogenchloride In dichloromethane; water for 0.333333h; pH=2-3;
Stage #2: di-tert-butyl dicarbonate With sodium hydroxide In dichloromethane; water at 0 - 50℃; pH=10-11;
100%
(6S)-1,1-dibromo-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylic acid
1412903-77-5

(6S)-1,1-dibromo-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylic acid

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

Conditions
ConditionsYield
With leaded bronze CuSn7Pb15 In methanol; N,N-dimethyl-formamide at 25℃; Reagent/catalyst; Solvent; Electrolysis;98%
With N-methyl-N,N,N-triethylammonium methylsulfate In N,N-dimethyl-formamide at 25℃; Electrolysis;93%
With palladium 10% on activated carbon; hydrogen; potassium hydroxide In isopropyl alcohol at 40℃; under 760.051 Torr; Inert atmosphere;82%
C28H34N2O5

C28H34N2O5

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran at 0 - 20℃; for 4h;97%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(S)-5-azaspiro[2.4]heptane-6-carboxylic acid D-tartrate

(S)-5-azaspiro[2.4]heptane-6-carboxylic acid D-tartrate

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

Conditions
ConditionsYield
Stage #1: di-tert-butyl dicarbonate; (S)-5-azaspiro[2.4]heptane-6-carboxylic acid D-tartrate With hydrogenchloride In dichloromethane; water pH=2;
Stage #2: di-tert-butyl dicarbonate With sodium hydroxide In dichloromethane; water at 0 - 20℃; for 15h; pH=10;
93%
C13H22BrNO4

C13H22BrNO4

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

Conditions
ConditionsYield
Stage #1: C13H22BrNO4 With sodium hydride In tetrahydrofuran at 0 - 50℃; for 10h;
Stage #2: With sodium hydroxide In tetrahydrofuran; water at 50℃; for 5h; Solvent; Reagent/catalyst;
92%
(6S)-5-tert-butyl 6-methyl 1,1-dibromo-5-azaspiro[2.4]heptane-5,6-dicarboxylate
1412903-76-4

(6S)-5-tert-butyl 6-methyl 1,1-dibromo-5-azaspiro[2.4]heptane-5,6-dicarboxylate

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

Conditions
ConditionsYield
With V-50; hypophosphorous acid; triethylamine In water at 100℃;79%
Multi-step reaction with 2 steps
1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 1.5 h / 20 °C
2: 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane / toluene / 7 h / 110 °C
View Scheme
C14H23NO4

C14H23NO4

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

Conditions
ConditionsYield
With water; lithium hydroxide In 2-methyltetrahydrofuran at 50℃;71%
(S)-6-hydroxymethyl-5-azaspiro[2.4]heptane-5-carboxylic acid tert-butyl ester
1262397-12-5

(S)-6-hydroxymethyl-5-azaspiro[2.4]heptane-5-carboxylic acid tert-butyl ester

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

Conditions
ConditionsYield
With Jones reagent In acetone at 0 - 37℃; for 2h;70%
(±)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylic acid

(±)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylic acid

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

Conditions
ConditionsYield
With (1S,2R)-1-amino-2-indanol In 2-methyltetrahydrofuran at 55℃; for 1.16667h;33%
Multi-step reaction with 2 steps
1: 2-methyltetrahydrofuran / 1 h / 55 °C
2: hydrogenchloride / water; 2-methyltetrahydrofuran / 0.5 h
View Scheme
Multi-step reaction with 2 steps
1: isopropyl alcohol; Isopropyl acetate / 60 °C
2: hydrogenchloride / water; Isopropyl acetate / 0 °C / pH 3 - 4
View Scheme
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: triethylamine
2.1: sodium periodate; ruthenium trichloride
4.1: diethylzinc; trifluoroacetic acid / hexane; dichloromethane / 1 h / -5 °C / Inert atmosphere
4.2: 72 h / -5 - 30 °C / Inert atmosphere
4.3: 24 h / 20 °C
5.1: water; sodium hydroxide / ethanol / 24 h
View Scheme
Multi-step reaction with 5 steps
1.1: triethylamine
2.1: sodium periodate; ruthenium trichloride
4.1: diethylzinc; trifluoroacetic acid / hexane; dichloromethane / 1 h / -5 °C / Inert atmosphere
4.2: 72 h / -5 - 30 °C / Inert atmosphere
5.1: water; sodium hydroxide / ethanol / 24 h
View Scheme
(S)-1-tert-butyl 2-methyl 4-methylenepyrrolidine-1,2-dicarboxylate
84348-39-0

(S)-1-tert-butyl 2-methyl 4-methylenepyrrolidine-1,2-dicarboxylate

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: diethylzinc; trifluoroacetic acid / hexane; dichloromethane / 1 h / -5 °C / Inert atmosphere
1.2: 72 h / -5 - 30 °C / Inert atmosphere
1.3: 24 h / 20 °C
2.1: water; sodium hydroxide / ethanol / 24 h
View Scheme
Multi-step reaction with 2 steps
1.1: diethylzinc; trifluoroacetic acid / hexane; dichloromethane / 1 h / -5 °C / Inert atmosphere
1.2: 72 h / -5 - 30 °C / Inert atmosphere
2.1: water; sodium hydroxide / ethanol / 24 h
View Scheme
Multi-step reaction with 3 steps
1.1: tetrabutylammomium bromide / 1,2-dichloro-ethane / 3.17 h / 70 °C / Inert atmosphere
2.1: 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane / toluene / 24 h / 0 - 90 °C
3.1: water; lithium hydroxide monohydrate / ethanol / 20 h / 20 °C
3.2: pH 2 / Ice bath
View Scheme
4R-4-hydroxyproline
51-35-4

4R-4-hydroxyproline

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: thionyl chloride
2.1: triethylamine
3.1: sodium periodate; ruthenium trichloride
5.1: diethylzinc; trifluoroacetic acid / hexane; dichloromethane / 1 h / -5 °C / Inert atmosphere
5.2: 72 h / -5 - 30 °C / Inert atmosphere
5.3: 24 h / 20 °C
6.1: water; sodium hydroxide / ethanol / 24 h
View Scheme
Multi-step reaction with 6 steps
1.1: thionyl chloride
2.1: triethylamine
3.1: sodium periodate; ruthenium trichloride
5.1: diethylzinc; trifluoroacetic acid / hexane; dichloromethane / 1 h / -5 °C / Inert atmosphere
5.2: 72 h / -5 - 30 °C / Inert atmosphere
6.1: water; sodium hydroxide / ethanol / 24 h
View Scheme
(S)-1-(tert-butoxycarbonyl)-4-methylenepyrrolidine-2-carboxylic acid
84348-38-9

(S)-1-(tert-butoxycarbonyl)-4-methylenepyrrolidine-2-carboxylic acid

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: potassium carbonate; N,N-dimethyl-formamide / 7 h / 20 °C
2.1: tetrabutylammomium bromide / 1,2-dichloro-ethane / 3.17 h / 70 °C / Inert atmosphere
3.1: 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane / toluene / 24 h / 0 - 90 °C
4.1: water; lithium hydroxide monohydrate / ethanol / 20 h / 20 °C
4.2: pH 2 / Ice bath
View Scheme
Multi-step reaction with 4 steps
1: potassium carbonate; N,N-dimethyl-formamide / 7 h / 20 °C
2: tetrabutylammomium bromide / 1,2-dichloro-ethane / 3.17 h / 70 °C / Inert atmosphere
3: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 1.5 h / 20 °C
4: 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane / toluene / 7 h / 110 °C
View Scheme
Multi-step reaction with 2 steps
1: benzyltrimethylammonium chloride; sodium hydroxide / dichloromethane / 33 - 38 °C
2: palladium 10% on activated carbon; potassium hydroxide; hydrogen / isopropyl alcohol / 40 °C / 760.05 Torr / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: sodium hydroxide; benzyltrimethylammonium chloride / dichloromethane / 1 h / 28 - 38 °C
2: potassium hydroxide; 8 % Pd/C; hydrogen / isopropyl alcohol / 38 °C / 1520.1 Torr
View Scheme
Multi-step reaction with 3 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
2.1: trifluoroacetic acid; diethylzinc / dichloromethane; hexane / 2 h / 5 °C / Inert atmosphere
2.2: 90 h / Inert atmosphere
3.1: water; lithium hydroxide / tetrahydrofuran / 20 °C
View Scheme
(3R,7aS)-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one
103201-79-2

(3R,7aS)-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -50 - -40 °C
1.2: 0.5 h / -55 - -45 °C
2.1: potassium hydrogencarbonate / methanol; water / 10 - 50 °C
3.1: potassium tert-butylate / tetrahydrofuran / 1 h / 10 - 60 °C
3.2: 10 - 60 °C
4.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 50 - 60 °C
5.1: palladium 10% on activated carbon; ammonium formate / methanol; water / 10 - 50 °C / Inert atmosphere
6.1: dichloromethane / 20 - 45 °C
6.2: 20 °C
7.1: Jones reagent / acetone / 2 h / 0 - 37 °C
View Scheme
C15H20N2O2

C15H20N2O2

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: potassium hydrogencarbonate / methanol; water / 10 - 50 °C
2.1: potassium tert-butylate / tetrahydrofuran / 1 h / 10 - 60 °C
2.2: 10 - 60 °C
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 50 - 60 °C
4.1: palladium 10% on activated carbon; ammonium formate / methanol; water / 10 - 50 °C / Inert atmosphere
5.1: dichloromethane / 20 - 45 °C
5.2: 20 °C
6.1: Jones reagent / acetone / 2 h / 0 - 37 °C
View Scheme
(3R,7aS)-6-methylene-3-phenyltetrahydropyrrolo[1,2-c]oxazol-5(1H)-one
958275-39-3

(3R,7aS)-6-methylene-3-phenyltetrahydropyrrolo[1,2-c]oxazol-5(1H)-one

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: potassium tert-butylate / tetrahydrofuran / 1 h / 10 - 60 °C
1.2: 10 - 60 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 50 - 60 °C
3.1: palladium 10% on activated carbon; ammonium formate / methanol; water / 10 - 50 °C / Inert atmosphere
4.1: dichloromethane / 20 - 45 °C
4.2: 20 °C
5.1: Jones reagent / acetone / 2 h / 0 - 37 °C
View Scheme
(3’R,7a’S)-3’-phenyldihydro-1‘H-spiro[cyclopropane-1,6’-pyrrolo[1,2-c][1,3]oxazol]-5’-one
1431322-84-7

(3’R,7a’S)-3’-phenyldihydro-1‘H-spiro[cyclopropane-1,6’-pyrrolo[1,2-c][1,3]oxazol]-5’-one

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 50 - 60 °C
2.1: palladium 10% on activated carbon; ammonium formate / methanol; water / 10 - 50 °C / Inert atmosphere
3.1: dichloromethane / 20 - 45 °C
3.2: 20 °C
4.1: Jones reagent / acetone / 2 h / 0 - 37 °C
View Scheme
((S)-(5-benzyl-5-azaspiro[2.4]heptan-6-yl)methanol)
1431322-85-8

((S)-(5-benzyl-5-azaspiro[2.4]heptan-6-yl)methanol)

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: palladium 10% on activated carbon; ammonium formate / methanol; water / 10 - 50 °C / Inert atmosphere
2.1: dichloromethane / 20 - 45 °C
2.2: 20 °C
3.1: Jones reagent / acetone / 2 h / 0 - 37 °C
View Scheme
(S)-1-(5-azaspiro[2.4]hept-6-yl)methanol
1431322-86-9

(S)-1-(5-azaspiro[2.4]hept-6-yl)methanol

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: dichloromethane / 20 - 45 °C
1.2: 20 °C
2.1: Jones reagent / acetone / 2 h / 0 - 37 °C
View Scheme
(S)-Pyroglutaminol
17342-08-4

(S)-Pyroglutaminol

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: toluene-4-sulfonic acid / toluene / Reflux; Dean-Stark
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -50 - -40 °C
2.2: 0.5 h / -55 - -45 °C
3.1: potassium hydrogencarbonate / methanol; water / 10 - 50 °C
4.1: potassium tert-butylate / tetrahydrofuran / 1 h / 10 - 60 °C
4.2: 10 - 60 °C
5.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 50 - 60 °C
6.1: palladium 10% on activated carbon; ammonium formate / methanol; water / 10 - 50 °C / Inert atmosphere
7.1: dichloromethane / 20 - 45 °C
7.2: 20 °C
8.1: Jones reagent / acetone / 2 h / 0 - 37 °C
View Scheme
Chloroiodomethane
593-71-5

Chloroiodomethane

(S)-1-(tert-butoxycarbonyl)-4-methylenepyrrolidine-2-carboxylic acid
84348-38-9

(S)-1-(tert-butoxycarbonyl)-4-methylenepyrrolidine-2-carboxylic acid

A

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

B

C11H16INO4

C11H16INO4

Conditions
ConditionsYield
Stage #1: Chloroiodomethane; (S)-1-(tert-butoxycarbonyl)-4-methylenepyrrolidine-2-carboxylic acid With diethylzinc In n-heptane; dichloromethane at -5 - 20℃; for 19.5h;
Stage #2: With lithium hydroxide monohydrate; water In methanol at 15 - 25℃; for 13.5h;
Stage #3: With iodine; sodium hydrogencarbonate In water at 25℃; for 40h;
[1-(hydroxymethyl)cyclopropyl]methanol
39590-81-3

[1-(hydroxymethyl)cyclopropyl]methanol

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: triphenylphosphine; 1H-imidazole; iodine / dichloromethane / 2.5 h / 0 - 10 °C
2: sodium hydride / mineral oil; N,N-dimethyl acetamide / 1 h / 0 - 11 °C
3: water; lithium hydroxide / 2-methyltetrahydrofuran / 50 °C
4: 2-methyltetrahydrofuran / 1 h / 55 °C
5: hydrogenchloride / water; 2-methyltetrahydrofuran / 0.5 h
View Scheme
Multi-step reaction with 6 steps
1: triethylamine / acetone / 3 h / 0 - 20 °C
2: sodium iodide / acetone / 35 °C
3: sodium hydride / mineral oil; N,N-dimethyl acetamide / 1 h / 0 - 11 °C
4: water; lithium hydroxide / 2-methyltetrahydrofuran / 50 °C
5: 2-methyltetrahydrofuran / 1 h / 55 °C
6: hydrogenchloride / water; 2-methyltetrahydrofuran / 0.5 h
View Scheme
Multi-step reaction with 4 steps
1: triphenylphosphine; iodine; 1H-imidazole / dichloromethane / 3 h / 10 °C
2: sodium hydride / N,N-dimethyl acetamide; mineral oil / 4.5 h / 0 - 11 °C
3: lithium hydroxide; water / 2-methyltetrahydrofuran / 50 °C / Inert atmosphere
4: (1S,2R)-1-amino-2-indanol / 2-methyltetrahydrofuran / 1.17 h / 55 °C
View Scheme
[1-(hydroxymethyl)cyclopropyl]methanol
39590-81-3

[1-(hydroxymethyl)cyclopropyl]methanol

A

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

B

C14H23NO4

C14H23NO4

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triphenylphosphine; 1H-imidazole; iodine / dichloromethane / 2.5 h / 0 - 10 °C
2: sodium hydride / mineral oil; N,N-dimethyl acetamide / 1 h / 0 - 11 °C
3: Novozym® 435 / aq. phosphate buffer; acetonitrile / 40 °C / pH 7 / Resolution of racemate
View Scheme
Multi-step reaction with 4 steps
1: triethylamine / acetone / 3 h / 0 - 20 °C
2: sodium iodide / acetone / 35 °C
3: sodium hydride / mineral oil; N,N-dimethyl acetamide / 1 h / 0 - 11 °C
4: Novozym® 435 / aq. phosphate buffer; acetonitrile / 40 °C / pH 7 / Resolution of racemate
View Scheme
1,1-bis(iodomethyl)cyclopropane
83321-23-7

1,1-bis(iodomethyl)cyclopropane

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 1 h / 0 - 11 °C
2: water; lithium hydroxide / 2-methyltetrahydrofuran / 50 °C
3: 2-methyltetrahydrofuran / 1 h / 55 °C
4: hydrogenchloride / water; 2-methyltetrahydrofuran / 0.5 h
View Scheme
Multi-step reaction with 3 steps
1: sodium hydride / N,N-dimethyl acetamide; mineral oil / 4.5 h / 0 - 11 °C
2: lithium hydroxide; water / 2-methyltetrahydrofuran / 50 °C / Inert atmosphere
3: (1S,2R)-1-amino-2-indanol / 2-methyltetrahydrofuran / 1.17 h / 55 °C
View Scheme
1,1-bis(iodomethyl)cyclopropane
83321-23-7

1,1-bis(iodomethyl)cyclopropane

A

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

B

C14H23NO4

C14H23NO4

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 1 h / 0 - 11 °C
2: Novozym® 435 / aq. phosphate buffer; acetonitrile / 40 °C / pH 7 / Resolution of racemate
View Scheme
picolinic acid hydrazide
1452-63-7

picolinic acid hydrazide

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

C18H24N4O4

C18H24N4O4

Conditions
ConditionsYield
Stage #1: (6S)-5-[(tert-butoxy)carbonyl]-5-azaspiro[2.4]heptane-6-carboxylic acid With 1-methyl-1H-imidazole; methanesulfonyl chloride In N,N-dimethyl-formamide at 0℃; for 0.25h;
Stage #2: picolinic acid hydrazide In N,N-dimethyl-d6-formamide for 6h;
100%
Stage #1: (6S)-5-[(tert-butoxy)carbonyl]-5-azaspiro[2.4]heptane-6-carboxylic acid With 1-methyl-1H-imidazole; methanesulfonyl chloride In N,N-dimethyl-formamide at 0℃; for 0.25h;
Stage #2: picolinic acid hydrazide In N,N-dimethyl-formamide for 6h;
100%
(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

C12H10BrF3O4S

C12H10BrF3O4S

C24H28F3NO8S

C24H28F3NO8S

Conditions
ConditionsYield
With triethylamine In acetonitrile at 0 - 20℃; for 2h;100%
(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

1-(7-bromo-9,9-difluoro-9-hydrofluoren-2-yl)-2-chloroethanone

1-(7-bromo-9,9-difluoro-9-hydrofluoren-2-yl)-2-chloroethanone

(S)-6-(2-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-2-oxoethyl) 5-tert-butyl 5-azaspiro[2.4]heptane-5,6-dicarboxylate

(S)-6-(2-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-2-oxoethyl) 5-tert-butyl 5-azaspiro[2.4]heptane-5,6-dicarboxylate

Conditions
ConditionsYield
Stage #1: (6S)-5-[(tert-butoxy)carbonyl]-5-azaspiro[2.4]heptane-6-carboxylic acid With potassium carbonate In acetone at 35℃; for 3h; Inert atmosphere;
Stage #2: 1-(7-bromo-9,9-difluoro-9-hydrofluoren-2-yl)-2-chloroethanone With sodium iodide In acetone at 35℃; for 3h;
97%
With potassium carbonate; potassium iodide In acetone at 60℃; for 3h;88%
With N-ethyl-N,N-diisopropylamine; potassium iodide In acetonitrile at 20℃; for 5h;
Stage #1: (6S)-5-[(tert-butoxy)carbonyl]-5-azaspiro[2.4]heptane-6-carboxylic acid With potassium tert-butylate In tetrahydrofuran at 30℃; for 25h;
Stage #2: 1-(7-bromo-9,9-difluoro-9-hydrofluoren-2-yl)-2-chloroethanone In acetone at 50℃; for 1.5h; Temperature;
(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

2-bromo-1-(4-iodophenyl)ethanone
31827-94-8

2-bromo-1-(4-iodophenyl)ethanone

C20H24INO5
1430104-98-5

C20H24INO5

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 3h;96%
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 0.25h;
(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

(S)-6-hydroxymethyl-5-azaspiro[2.4]heptane-5-carboxylic acid tert-butyl ester
1262397-12-5

(S)-6-hydroxymethyl-5-azaspiro[2.4]heptane-5-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With borane-dimethyl sulfide complex In tetrahydrofuran at -4 - 24℃; for 4.5h; Solvent; Temperature;92.8%
With borane-THF
(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

methyl chloroformate
79-22-1

methyl chloroformate

C10H15NO4
1383708-08-4

C10H15NO4

Conditions
ConditionsYield
With triethylamine92%
(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

C8H10NO4(1-)*K(1+)

C8H10NO4(1-)*K(1+)

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran; 2-methyltetrahydrofuran at 20 - 40℃; for 3h;86%
(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

(S)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylate
1441673-92-2

(S)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylate

Conditions
ConditionsYield
With potassium tert-butylate In 2-methyltetrahydrofuran at 20 - 40℃; for 3.5h;86%
With potassium tert-butylate In tetrahydrofuran at 10 - 40℃; for 6h;86%
(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

C21H15F2N3O*2ClH

C21H15F2N3O*2ClH

C45H49F2N5O7

C45H49F2N5O7

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 20℃;85%
(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

C21H17N3O*2ClH

C21H17N3O*2ClH

C45H51N5O7

C45H51N5O7

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 20℃;82%
(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

[6-[6-(trifluoromethyl)pyridin-3-yl]pyrimidin-4-yl]methanamine hydrochloride

[6-[6-(trifluoromethyl)pyridin-3-yl]pyrimidin-4-yl]methanamine hydrochloride

(S)-tert-butyl 6-(((6-(6-(trifluoromethyl)pyridin-3-yl)pyrimidin-4-yl)methyl)carbamoyl)-5-azaspiro[2.4]heptane-5-carboxylate

(S)-tert-butyl 6-(((6-(6-(trifluoromethyl)pyridin-3-yl)pyrimidin-4-yl)methyl)carbamoyl)-5-azaspiro[2.4]heptane-5-carboxylate

Conditions
ConditionsYield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In ethyl acetate at 20 - 60℃;76%
(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

trifluoroacetic acid
76-05-1

trifluoroacetic acid

(S)-6-carboxy-5-azaspiro[2.4]heptan-5-ium trifluoroacetate

(S)-6-carboxy-5-azaspiro[2.4]heptan-5-ium trifluoroacetate

Conditions
ConditionsYield
In dichloromethane at 0 - 20℃; for 16h;75%
In dichloromethane at 20℃; for 2h;
(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

benzyl chloroformate
501-53-1

benzyl chloroformate

(S)-5-((benzyloxy)carbonyl)-5-azaspiro[2.4]heptane-6-carboxylic acid
1256388-47-2

(S)-5-((benzyloxy)carbonyl)-5-azaspiro[2.4]heptane-6-carboxylic acid

Conditions
ConditionsYield
Stage #1: (6S)-5-[(tert-butoxy)carbonyl]-5-azaspiro[2.4]heptane-6-carboxylic acid With trifluoroacetic acid In dichloromethane at 20℃; for 3h;
Stage #2: benzyl chloroformate With sodium hydrogencarbonate In water at 0 - 20℃;
75%
pyrid-2-ylhydrazine
4930-98-7

pyrid-2-ylhydrazine

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

tert-butyl (S)-6-(2-(pyridin-2-yl)hydrazine-1-carbonyl)-5-azaspiro[2.4]heptane-5-carboxylate

tert-butyl (S)-6-(2-(pyridin-2-yl)hydrazine-1-carbonyl)-5-azaspiro[2.4]heptane-5-carboxylate

Conditions
ConditionsYield
Stage #1: (6S)-5-[(tert-butoxy)carbonyl]-5-azaspiro[2.4]heptane-6-carboxylic acid With 1-methyl-1H-imidazole; methanesulfonyl chloride In N,N-dimethyl-formamide at 0℃; for 0.25h;
Stage #2: pyrid-2-ylhydrazine In N,N-dimethyl-d6-formamide for 6h;
71%
Stage #1: (6S)-5-[(tert-butoxy)carbonyl]-5-azaspiro[2.4]heptane-6-carboxylic acid With 1-methyl-1H-imidazole; methanesulfonyl chloride In N,N-dimethyl-formamide at 0℃; for 0.25h;
Stage #2: pyrid-2-ylhydrazine In N,N-dimethyl-formamide for 6h;
71%
(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

N-cyclohexyl-2-fluoro-6-nitrobenzamide

N-cyclohexyl-2-fluoro-6-nitrobenzamide

tert-butyl (S)-6-(cyclohexyl(2-fluoro-6-nitrobenzoyl)carbamoyl)-5-azaspiro[2.4]heptane-5-carboxylate

tert-butyl (S)-6-(cyclohexyl(2-fluoro-6-nitrobenzoyl)carbamoyl)-5-azaspiro[2.4]heptane-5-carboxylate

Conditions
ConditionsYield
Stage #1: N-cyclohexyl-2-fluoro-6-nitrobenzamide With thionyl chloride In N,N-dimethyl-formamide at 80℃; for 2h; Inert atmosphere;
Stage #2: (6S)-5-[(tert-butoxy)carbonyl]-5-azaspiro[2.4]heptane-6-carboxylic acid With triethylamine In dichloromethane at 0 - 20℃; for 7h; Inert atmosphere;
56%
(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

2-amino-5-fluorobenzoic acid
446-08-2

2-amino-5-fluorobenzoic acid

aniline
62-53-3

aniline

tert-butyl (S)-6-(6-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)-5-azaspiro[2.4]heptane-5-carboxylate

tert-butyl (S)-6-(6-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)-5-azaspiro[2.4]heptane-5-carboxylate

Conditions
ConditionsYield
Stage #1: (6S)-5-[(tert-butoxy)carbonyl]-5-azaspiro[2.4]heptane-6-carboxylic acid; 2-amino-5-fluorobenzoic acid With pyridine; triphenyl phosphite at 70℃; Inert atmosphere;
Stage #2: aniline at 70℃; for 3h; Inert atmosphere;
54%
(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

N-cyclopentyl-2-fluoro-6-nitrobenzamide

N-cyclopentyl-2-fluoro-6-nitrobenzamide

tert-butyl (S)-6-(cyclopentyl(2-fluoro-6-nitrobenzoyl)carbamoyl)-5-azaspiro[2.4]heptane-5-carboxylate

tert-butyl (S)-6-(cyclopentyl(2-fluoro-6-nitrobenzoyl)carbamoyl)-5-azaspiro[2.4]heptane-5-carboxylate

Conditions
ConditionsYield
Stage #1: N-cyclopentyl-2-fluoro-6-nitrobenzamide With thionyl chloride In N,N-dimethyl-formamide at 80℃; for 2h; Inert atmosphere;
Stage #2: (6S)-5-[(tert-butoxy)carbonyl]-5-azaspiro[2.4]heptane-6-carboxylic acid With triethylamine In dichloromethane at 0 - 20℃; for 7h; Inert atmosphere;
53%
(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

2-amino-6-fluorobenzoic acid
434-76-4

2-amino-6-fluorobenzoic acid

aniline
62-53-3

aniline

tert-butyl (S)-6-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)-5-azaspiro[2.4]heptane-5-carboxylate

tert-butyl (S)-6-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)-5-azaspiro[2.4]heptane-5-carboxylate

Conditions
ConditionsYield
Stage #1: (6S)-5-[(tert-butoxy)carbonyl]-5-azaspiro[2.4]heptane-6-carboxylic acid; 2-amino-6-fluorobenzoic acid With pyridine; triphenyl phosphite at 70℃; Inert atmosphere;
Stage #2: aniline at 70℃; for 3h; Inert atmosphere;
53%
(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

para-bromophenacyl bromide
99-73-0

para-bromophenacyl bromide

C20H24BrNO5

C20H24BrNO5

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 2h;50%
(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid
1129634-44-1

(6S)-(5-(tert-butoxycarbonyl))-5-azaspiro[2.4]heptane-6-carboxylic acid

2-chloro-6-aminobenzoic acid
2148-56-3

2-chloro-6-aminobenzoic acid

aniline
62-53-3

aniline

(S)-6-(3-phenyl-4-oxo-5-chloro-3,4-dihydroquinazolin-2-yl)-5-azaspiro[2.4]heptane-5-carboxylic acid tert-butyl ester

(S)-6-(3-phenyl-4-oxo-5-chloro-3,4-dihydroquinazolin-2-yl)-5-azaspiro[2.4]heptane-5-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
Stage #1: (6S)-5-[(tert-butoxy)carbonyl]-5-azaspiro[2.4]heptane-6-carboxylic acid; 2-chloro-6-aminobenzoic acid With pyridine; triphenyl phosphite at 70℃; Inert atmosphere;
Stage #2: aniline for 3h; Inert atmosphere;
49%
Stage #1: (6S)-5-[(tert-butoxy)carbonyl]-5-azaspiro[2.4]heptane-6-carboxylic acid; 2-chloro-6-aminobenzoic acid With pyridine; triphenyl phosphite at 70℃; Inert atmosphere;
Stage #2: aniline at 70℃; for 3h; Inert atmosphere;
49%

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