Chemvon Biotechnology is one of the leading high-technology manufacturer in the field of pharmaceutical and fine chemical industry. From origins as a research group in technology service, chemvon has progressed into an integrated company with a k
Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryItems Standard Result Appearance White or almost white crystalline powder Complies Assay,HPLC 95.
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inquiryWe can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO
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inquiryCalcipotriol / Calcipotriene CAS:112828-00-9/112965-21-6 Calcipotriol Monohydrate CAS:147657-22-5 HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
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inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryName Calcipotriene Synonyms (1S,3S,5Z)-5-[(2E)-2-[(1R,3aR,7aR)-1-[(E,2S)-5-Cyclopropyl-5-hydroxy-pent-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-met
1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:112965-21-6
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inquiryBeluga chemical professional supply High quality,Calcipotriene manufacturers 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made in China an
Cas:112965-21-6
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Overview of Our Factories Our Factories production lines Our Factories R&D ability Our Factories warehouse Our Factorie
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
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inquiryHubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other
Cas:112965-21-6
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inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:112965-21-6
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inquiryFactory direct sales, accept customization. Calcipotriene also known as Calcipotriol, is a topical vitaminD3 derivative effective in the treatment of psoriasis vulgaris. The drug acts by binding to vitamin D3 receptors in the skin keratinocytes, pro
Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquiryWe are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
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inquiryWe have years of experience to produce Dapagliflozin .We can provide high quality,cheap price,spot supply and good service. If you have any questions,pls do not hesitate to contact us. Hangzhou Hysen pharma CO.,LTD. is a professional Pharmaceutical
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inquiryOur company was built in 2009 with an ISO certificate. In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so o
Cas:112965-21-6
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Type:Lab/Research institutions
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:112965-21-6
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Type:Lab/Research institutions
inquiry(1S,3R)-bis(tert-butyldimethylsilyloxy)-20(R)-(3'(S)-cyclopropyl-3'-hydroxyprop-1'(E)-enyl)-9,10-secopregna-5(Z),7(E),10(19)-triene
calcipotriene
Conditions | Yield |
---|---|
With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; | 87% |
With tetrabutyl ammonium fluoride In tetrahydrofuran at 60℃; for 0.833333h; | 73% |
With tetrabutyl ammonium fluoride In tetrahydrofuran at 40℃; for 2h; | |
With tetrabutyl ammonium fluoride In tetrahydrofuran at 60℃; | |
Stage #1: (1S,3R)-bis(tert-butyldimethylsilyloxy)-20(R)-(3'(S)-cyclopropyl-3'-hydroxyprop-1'(E)-enyl)-9,10-secopregna-5(Z),7(E),10(19)-triene With tetrabutyl ammonium fluoride In tetrahydrofuran at 60 - 65℃; for 2h; Stage #2: With water; sodium hydrogencarbonate In tetrahydrofuran; ethyl acetate for 0.25h; |
Cyclopropyl methyl ketone
calcipotriene
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1: 87 percent / bromine / methanol / 0.5 h / Ambient temperature 2: 84 percent 3: 86 percent / 2N sodium hydroxide / H2O; CH2Cl2 5: N-methylmorpholine N-oxide, selenium dioxide 6: imidazole / dimethylformamide 7: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H 8: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation 9: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C View Scheme | |
Multi-step reaction with 7 steps 1: 87 percent / bromine / methanol / 0.5 h / Ambient temperature 2: 84 percent 3: 86 percent / 2N sodium hydroxide / H2O; CH2Cl2 4: dimethylsulfoxide / 4 h / 105 °C 5: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H 6: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation 7: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C View Scheme |
2-bromo-1-cyclopropylethan-1-one
calcipotriene
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: 84 percent 2: 86 percent / 2N sodium hydroxide / H2O; CH2Cl2 4: N-methylmorpholine N-oxide, selenium dioxide 5: imidazole / dimethylformamide 6: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H 7: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation 8: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C View Scheme | |
Multi-step reaction with 6 steps 1: 84 percent 2: 86 percent / 2N sodium hydroxide / H2O; CH2Cl2 3: dimethylsulfoxide / 4 h / 105 °C 4: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H 5: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation 6: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C View Scheme |
1-cyclopropyl-2-(triphenyl-λ5-phosphanylidene)ethan-1-one
calcipotriene
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 2: N-methylmorpholine N-oxide, selenium dioxide 3: imidazole / dimethylformamide 4: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H 5: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation 6: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C View Scheme | |
Multi-step reaction with 4 steps 1: dimethylsulfoxide / 4 h / 105 °C 2: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H 3: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation 4: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C View Scheme |
3(R)-(tert-butyldimethylsilyloxy)-20(S)-formyl-9,10-secopregna-5(Z),7(E),10(19)-triene
calcipotriene
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 2: N-methylmorpholine N-oxide, selenium dioxide 3: imidazole / dimethylformamide 4: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H 5: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation 6: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C View Scheme |
(S)-3-[(1R,3aS,7aR)-7a-Methyl-1-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-(4E)-ylidenemethyl]-2,2-dioxo-2,3,4,5,6,7-hexahydro-1H-2λ6-benzo[c]thiophen-5-ol
calcipotriene
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1: 42 percent / imidazole / dimethylformamide / 1.5 h / 20 °C 2: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C 2.) CH2Cl2, MeOH, -60 to 0 deg C 3: NaHCO3 / aq. ethanol / Heating 5: N-methylmorpholine N-oxide, selenium dioxide 6: imidazole / dimethylformamide 7: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H 8: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation 9: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C View Scheme | |
Multi-step reaction with 9 steps 1: 52 percent / imidazole / dimethylformamide / 1.5 h / 20 °C 2: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C 2.) CH2Cl2, MeOH, -60 to 0 deg C 3: NaHCO3 / aq. ethanol / Heating 5: N-methylmorpholine N-oxide, selenium dioxide 6: imidazole / dimethylformamide 7: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H 8: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation 9: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C View Scheme |
20(R),3(R)-(tert-butyldimethylsilyloxy)-20-(3'-cyclopropyl-3'-oxoprop-1'(E)-enyl)-9,10-secopregna-5(Z),7(E),10(19)-triene
calcipotriene
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: N-methylmorpholine N-oxide, selenium dioxide 2: imidazole / dimethylformamide 3: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H 4: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation 5: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C View Scheme |
calcipotriene
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: imidazole / dimethylformamide 2: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H 3: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation 4: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C View Scheme |
(2-cyclopropyl-2-oxoethyl) (triphenyl)phosphonium bromide
calcipotriene
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 86 percent / 2N sodium hydroxide / H2O; CH2Cl2 3: N-methylmorpholine N-oxide, selenium dioxide 4: imidazole / dimethylformamide 5: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H 6: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation 7: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C View Scheme | |
Multi-step reaction with 5 steps 1: 86 percent / 2N sodium hydroxide / H2O; CH2Cl2 2: dimethylsulfoxide / 4 h / 105 °C 3: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H 4: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation 5: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C View Scheme |
(7Z)-Vitamin D2
calcipotriene
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1: liq. SO2 / 0.5 h / Heating 2: 42 percent / imidazole / dimethylformamide / 1.5 h / 20 °C 3: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C 2.) CH2Cl2, MeOH, -60 to 0 deg C 4: NaHCO3 / aq. ethanol / Heating 6: N-methylmorpholine N-oxide, selenium dioxide 7: imidazole / dimethylformamide 8: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H 9: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation 10: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C View Scheme | |
Multi-step reaction with 10 steps 1: liq. SO2 / 0.5 h / Heating 2: 52 percent / imidazole / dimethylformamide / 1.5 h / 20 °C 3: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C 2.) CH2Cl2, MeOH, -60 to 0 deg C 4: NaHCO3 / aq. ethanol / Heating 6: N-methylmorpholine N-oxide, selenium dioxide 7: imidazole / dimethylformamide 8: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H 9: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation 10: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C View Scheme |
3(S)-tert-butyldimethylsilyloxy-20(S)-formyl-9,10-secoprega-5,7(E),10(19)-triene
calcipotriene
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: NaHCO3 / aq. ethanol / Heating 3: N-methylmorpholine N-oxide, selenium dioxide 4: imidazole / dimethylformamide 5: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H 6: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation 7: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C View Scheme |
3(S)-tert-butyldimethylsilyloxy-20(S)-formyl-9,10-secoprega-5,7(E),10(19)-triene
calcipotriene
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: NaHCO3 / aq. ethanol / Heating 3: N-methylmorpholine N-oxide, selenium dioxide 4: imidazole / dimethylformamide 5: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H 6: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation 7: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C View Scheme |
(3S,6R)-(tert-butyldimethylsilyloxy)-9,10-seco-ergosta-5,7(E),10(19),22(E)-tetraene SO2 adduct
calcipotriene
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C 2.) CH2Cl2, MeOH, -60 to 0 deg C 2: NaHCO3 / aq. ethanol / Heating 4: N-methylmorpholine N-oxide, selenium dioxide 5: imidazole / dimethylformamide 6: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H 7: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation 8: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C View Scheme |
(3S,6S)-(tert-butyldimethylsilyloxy)-9,10-seco-ergosta-5,7(E),10(19),22(E)-tetraene SO2-adduct
calcipotriene
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C 2.) CH2Cl2, MeOH, -60 to 0 deg C 2: NaHCO3 / aq. ethanol / Heating 4: N-methylmorpholine N-oxide, selenium dioxide 5: imidazole / dimethylformamide 6: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H 7: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation 8: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C View Scheme |
(1S,3R,3'S)-bis(tert-butyldimethylsilyloxy)-20(R)-(3'-cyclopropyl-3'-hydroxyprop-1'(E)-enyl)-9,10-secopregna-5(E),7(E),10(19)-triene
calcipotriene
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation 2: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C View Scheme |
1(S),3(R)-bis(tert-butyldimethylsilyloxy)-20(R)-(3’-cyclopropyl-3’-oxypropyl-1’(E)-enyl)-9,10-secopregna-5(E),7(E),10(19)-triene
calcipotriene
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H 2: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation 3: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C View Scheme |
A
20(R)-(3'(R)-cyclopropyl-3'-hydroxyprop-1'(E)-enyl)-1(S),3(R)-dihydroxy-9,10-secopregna-5(Z),7(E),10(19)-triene
B
calcipotriene
Conditions | Yield |
---|---|
With silica gel In hexane; dichloromethane for 24h; Product distribution / selectivity; |
Conditions | Yield |
---|---|
In acetone for 3h; Purification / work up; |
PRI-2205
calcipotriene
Conditions | Yield |
---|---|
With 9-acetylanthracene In acetone at 10℃; Product distribution / selectivity; UV-irradiation; |
C27H40O3
B
calcipotriene
Conditions | Yield |
---|---|
With 9-acetylanthracene In acetone at 10℃; Product distribution / selectivity; UV-irradiation; |
C35H60O2Si2
calcipotriene
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: bis(cyclohexanyl)borane; diethylzinc; (2R)-3-exo-(dimethylamino)isoborneol / hexane / -20 - 0 °C 1.2: 0 °C 2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C View Scheme |
[(2Z)-2-[(3S,5R)-3,5-bis(tert-butyldimethylsilanyloxy)-2-methylenecyclohexylidene]ethyl]diphenylphosphine oxide
calcipotriene
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: n-hexyllithium / -78 °C 2.1: bis(cyclohexanyl)borane; diethylzinc; (2R)-3-exo-(dimethylamino)isoborneol / hexane / -20 - 0 °C 2.2: 0 °C 3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C View Scheme |
calcipotriene
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: 2,4,6-trimethyl-pyridine; trifluoroacetic anhydride / acetonitrile / 0.17 h / 30 °C / Inert atmosphere 1.2: 0.08 h 2.1: dichloromethane / 0.17 h / -50 °C / Inert atmosphere 3.1: N-ethyl-N,N-diisopropylamine / water; acetonitrile 4.1: hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide / isopropyl alcohol / 20 - 30 °C 5.1: potassium hexamethylsilazane / tetrahydrofuran / 2 h / -50 °C / Inert atmosphere 6.1: triethylamine; anthracene / toluene / 1.5 h / 20 °C / UV-irradiation 6.2: 1 h / 60 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: 2,4,6-trimethyl-pyridine; trifluoroacetic anhydride / acetonitrile / 0.17 h / 30 °C / Inert atmosphere 1.2: 0.08 h 2.1: dichloromethane / 0.17 h / -50 °C / Inert atmosphere 3.1: lithium diisopropyl amide / tetrahydrofuran; N,N-dimethyl-formamide / 0.08 h 3.2: 2 h / 30 °C 4.1: 3-chloro-benzenecarboperoxoic acid / acetonitrile / 0 - 20 °C 5.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -30 °C / Inert atmosphere 6.1: triethylamine; anthracene / toluene / 1.5 h / 20 °C / UV-irradiation 6.2: 1 h / 60 °C View Scheme |
calcipotriene
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: potassium carbonate; acetic anhydride / acetonitrile / 0.5 h / 50 °C / Inert atmosphere 1.2: 0.17 h 2.1: triethylamine / acetonitrile / 0.5 h / 0 °C / Inert atmosphere 3.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.08 h / Inert atmosphere 3.2: 2 h / 30 °C 4.1: 3-chloro-benzenecarboperoxoic acid / acetonitrile / 0 - 20 °C 5.1: sodium hexamethyldisilazane / diethyl ether / 3 h / -80 °C / Inert atmosphere 6.1: triethylamine; anthracene / toluene / 1.5 h / UV-irradiation 6.2: 1 h / 60 °C 6.3: 3 h / 20 °C View Scheme |
calcipotriene
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / -30 °C / Inert atmosphere 2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C 3.1: 3-chloro-benzenecarboperoxoic acid / acetonitrile / 2 h / 20 - 50 °C 4.1: lithium hexamethyldisilazane / tetrahydrofuran; 1,4-dioxane / 2 h / -20 °C / Inert atmosphere 5.1: triethylamine; anthracene / toluene / 1.5 h / UV-irradiation 5.2: 1 h / 60 °C 5.3: 3 h / 20 °C / 760.05 Torr View Scheme |
calcipotriene
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: dichloromethane / 0.17 h / -50 °C / Inert atmosphere 2.1: N-ethyl-N,N-diisopropylamine / water; acetonitrile 3.1: hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide / isopropyl alcohol / 20 - 30 °C 4.1: potassium hexamethylsilazane / tetrahydrofuran / 2 h / -50 °C / Inert atmosphere 5.1: triethylamine; anthracene / toluene / 1.5 h / 20 °C / UV-irradiation 5.2: 1 h / 60 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: dichloromethane / 0.17 h / -50 °C / Inert atmosphere 2.1: lithium diisopropyl amide / tetrahydrofuran; N,N-dimethyl-formamide / 0.08 h 2.2: 2 h / 30 °C 3.1: 3-chloro-benzenecarboperoxoic acid / acetonitrile / 0 - 20 °C 4.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -30 °C / Inert atmosphere 5.1: triethylamine; anthracene / toluene / 1.5 h / 20 °C / UV-irradiation 5.2: 1 h / 60 °C View Scheme |
calcipotriene
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: triethylamine / acetonitrile / 0.5 h / 0 °C / Inert atmosphere 2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.08 h / Inert atmosphere 2.2: 2 h / 30 °C 3.1: 3-chloro-benzenecarboperoxoic acid / acetonitrile / 0 - 20 °C 4.1: sodium hexamethyldisilazane / diethyl ether / 3 h / -80 °C / Inert atmosphere 5.1: triethylamine; anthracene / toluene / 1.5 h / UV-irradiation 5.2: 1 h / 60 °C 5.3: 3 h / 20 °C View Scheme |
calcipotriene
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C 2.1: 3-chloro-benzenecarboperoxoic acid / acetonitrile / 2 h / 20 - 50 °C 3.1: lithium hexamethyldisilazane / tetrahydrofuran; 1,4-dioxane / 2 h / -20 °C / Inert atmosphere 4.1: triethylamine; anthracene / toluene / 1.5 h / UV-irradiation 4.2: 1 h / 60 °C 4.3: 3 h / 20 °C / 760.05 Torr View Scheme |
all-cis-6,9,12-octadecatrienoic acid
calcipotriene
Conditions | Yield |
---|---|
With 4-(dimethylamino)pypiridine; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 3h; |
(9Z,12Z,15Z)-octadeca-9-12,15-trienoic acid
calcipotriene
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 3h; |
(9Z,12Z,15Z)-octadeca-9-12,15-trienoic acid
calcipotriene
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 3h; |
calcipotriene
Conditions | Yield |
---|---|
With water In ethyl acetate | |
With ammonia; water at 25 - 40℃; for 12 - 50h; pH=> 7; Product distribution / selectivity; |
calcipotriene
calci-dioxole
Conditions | Yield |
---|---|
With oxygen; methylene blue In methanol at 20℃; Photolysis; |
calcipotriene
Conditions | Yield |
---|---|
With hydrogenchloride; oxygen In ethanol at 20℃; |
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