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Chemvon Biotechnology Co. Ltd.

Chemvon Biotechnology is one of the leading high-technology manufacturer in the field of pharmaceutical and fine chemical industry. From origins as a research group in technology service, chemvon has progressed into an integrated company with a k

Calcipotriol

Cas:112965-21-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Calcipotriene/ LIDE PHARMA- Factory supply / Best price

Cas:112965-21-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Calcipotriene Manufacturer/High quality/Best price/In stock

Cas:112965-21-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance White or almost white crystalline powder Complies Assay,HPLC 95.

High purity Various Specifications Calcipotriene CAS:112965-21-6

Cas:112965-21-6

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

calcipotriol manufacturer/supplier

Cas:112965-21-6

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Hangzhou Think Chemical Co. Ltd

Calcipotriol / Calcipotriene CAS:112828-00-9/112965-21-6 Calcipotriol Monohydrate CAS:147657-22-5 HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years

Manufacture Calcipotriol or Calcipotriene and intermediates

Cas:112965-21-6

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Calcipotriol

Cas:112965-21-6

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Calcipotriene 112965-21-6 GMP Manufacturer

Cas:112965-21-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Calcipotriene

Cas:112965-21-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Calcipotriene

Cas:112965-21-6

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 112965-21-6 with competitive price

Cas:112965-21-6

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Name Calcipotriene Synonyms (1S,3S,5Z)-5-[(2E)-2-[(1R,3aR,7aR)-1-[(E,2S)-5-Cyclopropyl-5-hydroxy-pent-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-met

Calcipotriene

Cas:112965-21-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

High quality Calcipotriene 112965-21-6

Cas:112965-21-6

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Calcipotriene 112965-21-6

Cas:112965-21-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Calcipotriene

Cas:112965-21-6

Min.Order:1 Kilogram

FOB Price: $86.0 / 100.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply High quality,Calcipotriene manufacturers 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made in China an

High quality,Calcipotriene manufacturers

Cas:112965-21-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Calcipotriene

Cas:112965-21-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:112965-21-6

Cas:112965-21-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Leader Biochemical Group

Overview of Our Factories Our Factories production lines Our Factories R&D ability Our Factories warehouse Our Factorie

China Biggest Factory & Manufacturer supply Calcipotriene

Cas:112965-21-6

Min.Order:1 Kilogram

FOB Price: $5.0 / 10.0

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

99% BP Standard High Purity 99% Pharmaceutical Raw Materials Calcipotriene CAS 112965-21-6

Cas:112965-21-6

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

High Purity Calcipotriene CAS 112965-21-6 with Fast Shipment

Cas:112965-21-6

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Calcipotriene 112965-21-6

Cas:112965-21-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Tianjin Kind Pharma Co., Ltd.

Factory direct sales, accept customization. Calcipotriene also known as Calcipotriol, is a topical vitaminD3 derivative effective in the treatment of psoriasis vulgaris. The drug acts by binding to vitamin D3 receptors in the skin keratinocytes, pro

calcipotriol

Cas:112965-21-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

CALCIPOTRIOL

Cas:112965-21-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Calcipotriene

Cas:112965-21-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Calcipotriol

Cas:112965-21-6

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

99% BP Standard High Purity 99% Pharmaceutical Raw Materials Calcipotriene CAS 112965-21-6

Cas:112965-21-6

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Hangzhou Hysen Pharma co.,Ltd.

We have years of experience to produce Dapagliflozin .We can provide high quality,cheap price,spot supply and good service. If you have any questions,pls do not hesitate to contact us. Hangzhou Hysen pharma CO.,LTD. is a professional Pharmaceutical

Calcipotriol factory supply

Cas:112965-21-6

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate. In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so o

TIANFU CHEM Calcipotriene

Cas:112965-21-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Calcipotriene Manufacturer/High quality/Best price/In stock

Cas:112965-21-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

(1S,3R)-bis(tert-butyldimethylsilyloxy)-20(R)-(3'(S)-cyclopropyl-3'-hydroxyprop-1'(E)-enyl)-9,10-secopregna-5(Z),7(E),10(19)-triene
112875-61-3

(1S,3R)-bis(tert-butyldimethylsilyloxy)-20(R)-(3'(S)-cyclopropyl-3'-hydroxyprop-1'(E)-enyl)-9,10-secopregna-5(Z),7(E),10(19)-triene

calcipotriene
112965-21-6

calcipotriene

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃;87%
With tetrabutyl ammonium fluoride In tetrahydrofuran at 60℃; for 0.833333h;73%
With tetrabutyl ammonium fluoride In tetrahydrofuran at 40℃; for 2h;
With tetrabutyl ammonium fluoride In tetrahydrofuran at 60℃;
Stage #1: (1S,3R)-bis(tert-butyldimethylsilyloxy)-20(R)-(3'(S)-cyclopropyl-3'-hydroxyprop-1'(E)-enyl)-9,10-secopregna-5(Z),7(E),10(19)-triene With tetrabutyl ammonium fluoride In tetrahydrofuran at 60 - 65℃; for 2h;
Stage #2: With water; sodium hydrogencarbonate In tetrahydrofuran; ethyl acetate for 0.25h;
Cyclopropyl methyl ketone
765-43-5

Cyclopropyl methyl ketone

calcipotriene
112965-21-6

calcipotriene

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: 87 percent / bromine / methanol / 0.5 h / Ambient temperature
2: 84 percent
3: 86 percent / 2N sodium hydroxide / H2O; CH2Cl2
5: N-methylmorpholine N-oxide, selenium dioxide
6: imidazole / dimethylformamide
7: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H
8: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation
9: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C
View Scheme
Multi-step reaction with 7 steps
1: 87 percent / bromine / methanol / 0.5 h / Ambient temperature
2: 84 percent
3: 86 percent / 2N sodium hydroxide / H2O; CH2Cl2
4: dimethylsulfoxide / 4 h / 105 °C
5: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H
6: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation
7: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C
View Scheme
2-bromo-1-cyclopropylethan-1-one
69267-75-0

2-bromo-1-cyclopropylethan-1-one

calcipotriene
112965-21-6

calcipotriene

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 84 percent
2: 86 percent / 2N sodium hydroxide / H2O; CH2Cl2
4: N-methylmorpholine N-oxide, selenium dioxide
5: imidazole / dimethylformamide
6: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H
7: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation
8: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C
View Scheme
Multi-step reaction with 6 steps
1: 84 percent
2: 86 percent / 2N sodium hydroxide / H2O; CH2Cl2
3: dimethylsulfoxide / 4 h / 105 °C
4: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H
5: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation
6: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C
View Scheme
1-cyclopropyl-2-(triphenyl-λ5-phosphanylidene)ethan-1-one
7691-76-1

1-cyclopropyl-2-(triphenyl-λ5-phosphanylidene)ethan-1-one

calcipotriene
112965-21-6

calcipotriene

Conditions
ConditionsYield
Multi-step reaction with 6 steps
2: N-methylmorpholine N-oxide, selenium dioxide
3: imidazole / dimethylformamide
4: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H
5: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation
6: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C
View Scheme
Multi-step reaction with 4 steps
1: dimethylsulfoxide / 4 h / 105 °C
2: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H
3: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation
4: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C
View Scheme
3(R)-(tert-butyldimethylsilyloxy)-20(S)-formyl-9,10-secopregna-5(Z),7(E),10(19)-triene
112828-12-3

3(R)-(tert-butyldimethylsilyloxy)-20(S)-formyl-9,10-secopregna-5(Z),7(E),10(19)-triene

calcipotriene
112965-21-6

calcipotriene

Conditions
ConditionsYield
Multi-step reaction with 6 steps
2: N-methylmorpholine N-oxide, selenium dioxide
3: imidazole / dimethylformamide
4: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H
5: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation
6: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C
View Scheme
(S)-3-[(1R,3aS,7aR)-7a-Methyl-1-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-(4E)-ylidenemethyl]-2,2-dioxo-2,3,4,5,6,7-hexahydro-1H-2λ6-benzo[c]thiophen-5-ol
87680-65-7

(S)-3-[(1R,3aS,7aR)-7a-Methyl-1-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-(4E)-ylidenemethyl]-2,2-dioxo-2,3,4,5,6,7-hexahydro-1H-2λ6-benzo[c]thiophen-5-ol

calcipotriene
112965-21-6

calcipotriene

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: 42 percent / imidazole / dimethylformamide / 1.5 h / 20 °C
2: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C 2.) CH2Cl2, MeOH, -60 to 0 deg C
3: NaHCO3 / aq. ethanol / Heating
5: N-methylmorpholine N-oxide, selenium dioxide
6: imidazole / dimethylformamide
7: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H
8: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation
9: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C
View Scheme
Multi-step reaction with 9 steps
1: 52 percent / imidazole / dimethylformamide / 1.5 h / 20 °C
2: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C 2.) CH2Cl2, MeOH, -60 to 0 deg C
3: NaHCO3 / aq. ethanol / Heating
5: N-methylmorpholine N-oxide, selenium dioxide
6: imidazole / dimethylformamide
7: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H
8: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation
9: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C
View Scheme
20(R),3(R)-(tert-butyldimethylsilyloxy)-20-(3'-cyclopropyl-3'-oxoprop-1'(E)-enyl)-9,10-secopregna-5(Z),7(E),10(19)-triene
112849-18-0

20(R),3(R)-(tert-butyldimethylsilyloxy)-20-(3'-cyclopropyl-3'-oxoprop-1'(E)-enyl)-9,10-secopregna-5(Z),7(E),10(19)-triene

calcipotriene
112965-21-6

calcipotriene

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: N-methylmorpholine N-oxide, selenium dioxide
2: imidazole / dimethylformamide
3: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H
4: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation
5: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C
View Scheme
(E)-(R)-4-{(1R,3aS,7aR)-4-[2-[(R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-2-methylene-cyclohex-(E)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-1-cyclopropyl-pent-2-en-1-one

(E)-(R)-4-{(1R,3aS,7aR)-4-[2-[(R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-2-methylene-cyclohex-(E)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-1-cyclopropyl-pent-2-en-1-one

calcipotriene
112965-21-6

calcipotriene

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: imidazole / dimethylformamide
2: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H
3: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation
4: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C
View Scheme
(2-cyclopropyl-2-oxoethyl) (triphenyl)phosphonium bromide
112849-15-7

(2-cyclopropyl-2-oxoethyl) (triphenyl)phosphonium bromide

calcipotriene
112965-21-6

calcipotriene

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 86 percent / 2N sodium hydroxide / H2O; CH2Cl2
3: N-methylmorpholine N-oxide, selenium dioxide
4: imidazole / dimethylformamide
5: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H
6: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation
7: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C
View Scheme
Multi-step reaction with 5 steps
1: 86 percent / 2N sodium hydroxide / H2O; CH2Cl2
2: dimethylsulfoxide / 4 h / 105 °C
3: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H
4: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation
5: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C
View Scheme
(7Z)-Vitamin D2
247900-07-8

(7Z)-Vitamin D2

calcipotriene
112965-21-6

calcipotriene

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: liq. SO2 / 0.5 h / Heating
2: 42 percent / imidazole / dimethylformamide / 1.5 h / 20 °C
3: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C 2.) CH2Cl2, MeOH, -60 to 0 deg C
4: NaHCO3 / aq. ethanol / Heating
6: N-methylmorpholine N-oxide, selenium dioxide
7: imidazole / dimethylformamide
8: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H
9: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation
10: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C
View Scheme
Multi-step reaction with 10 steps
1: liq. SO2 / 0.5 h / Heating
2: 52 percent / imidazole / dimethylformamide / 1.5 h / 20 °C
3: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C 2.) CH2Cl2, MeOH, -60 to 0 deg C
4: NaHCO3 / aq. ethanol / Heating
6: N-methylmorpholine N-oxide, selenium dioxide
7: imidazole / dimethylformamide
8: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H
9: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation
10: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C
View Scheme
3(S)-tert-butyldimethylsilyloxy-20(S)-formyl-9,10-secoprega-5,7(E),10(19)-triene
87407-47-4

3(S)-tert-butyldimethylsilyloxy-20(S)-formyl-9,10-secoprega-5,7(E),10(19)-triene

calcipotriene
112965-21-6

calcipotriene

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: NaHCO3 / aq. ethanol / Heating
3: N-methylmorpholine N-oxide, selenium dioxide
4: imidazole / dimethylformamide
5: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H
6: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation
7: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C
View Scheme
3(S)-tert-butyldimethylsilyloxy-20(S)-formyl-9,10-secoprega-5,7(E),10(19)-triene
87422-13-7

3(S)-tert-butyldimethylsilyloxy-20(S)-formyl-9,10-secoprega-5,7(E),10(19)-triene

calcipotriene
112965-21-6

calcipotriene

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: NaHCO3 / aq. ethanol / Heating
3: N-methylmorpholine N-oxide, selenium dioxide
4: imidazole / dimethylformamide
5: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H
6: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation
7: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C
View Scheme
(3S,6R)-(tert-butyldimethylsilyloxy)-9,10-seco-ergosta-5,7(E),10(19),22(E)-tetraene SO2 adduct
87417-26-3

(3S,6R)-(tert-butyldimethylsilyloxy)-9,10-seco-ergosta-5,7(E),10(19),22(E)-tetraene SO2 adduct

calcipotriene
112965-21-6

calcipotriene

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C 2.) CH2Cl2, MeOH, -60 to 0 deg C
2: NaHCO3 / aq. ethanol / Heating
4: N-methylmorpholine N-oxide, selenium dioxide
5: imidazole / dimethylformamide
6: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H
7: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation
8: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C
View Scheme
(3S,6S)-(tert-butyldimethylsilyloxy)-9,10-seco-ergosta-5,7(E),10(19),22(E)-tetraene SO2-adduct
87417-26-3, 87417-27-4

(3S,6S)-(tert-butyldimethylsilyloxy)-9,10-seco-ergosta-5,7(E),10(19),22(E)-tetraene SO2-adduct

calcipotriene
112965-21-6

calcipotriene

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C 2.) CH2Cl2, MeOH, -60 to 0 deg C
2: NaHCO3 / aq. ethanol / Heating
4: N-methylmorpholine N-oxide, selenium dioxide
5: imidazole / dimethylformamide
6: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H
7: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation
8: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C
View Scheme
(1S,3R,3'S)-bis(tert-butyldimethylsilyloxy)-20(R)-(3'-cyclopropyl-3'-hydroxyprop-1'(E)-enyl)-9,10-secopregna-5(E),7(E),10(19)-triene
112849-27-1

(1S,3R,3'S)-bis(tert-butyldimethylsilyloxy)-20(R)-(3'-cyclopropyl-3'-hydroxyprop-1'(E)-enyl)-9,10-secopregna-5(E),7(E),10(19)-triene

calcipotriene
112965-21-6

calcipotriene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation
2: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C
View Scheme
1(S),3(R)-bis(tert-butyldimethylsilyloxy)-20(R)-(3’-cyclopropyl-3’-oxypropyl-1’(E)-enyl)-9,10-secopregna-5(E),7(E),10(19)-triene
112849-17-9

1(S),3(R)-bis(tert-butyldimethylsilyloxy)-20(R)-(3’-cyclopropyl-3’-oxypropyl-1’(E)-enyl)-9,10-secopregna-5(E),7(E),10(19)-triene

calcipotriene
112965-21-6

calcipotriene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 33 percent / NaBH4, CeCl3*6H2O / methanol / further reag.: (S)-BINAL-H
2: anthracene, triethylamine / toluene / 1 h / 20 °C / Irradiation
3: 73 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 60 °C
View Scheme
(5Z,7E,22E)-(1S,3R,24R)-24-acetoxy-26,27-cyclo-9,10-secocholesta-5,7,10(19),22-tetraene-1,3-diol

(5Z,7E,22E)-(1S,3R,24R)-24-acetoxy-26,27-cyclo-9,10-secocholesta-5,7,10(19),22-tetraene-1,3-diol

A

20(R)-(3'(R)-cyclopropyl-3'-hydroxyprop-1'(E)-enyl)-1(S),3(R)-dihydroxy-9,10-secopregna-5(Z),7(E),10(19)-triene
112827-99-3

20(R)-(3'(R)-cyclopropyl-3'-hydroxyprop-1'(E)-enyl)-1(S),3(R)-dihydroxy-9,10-secopregna-5(Z),7(E),10(19)-triene

B

calcipotriene
112965-21-6

calcipotriene

Conditions
ConditionsYield
With silica gel In hexane; dichloromethane for 24h; Product distribution / selectivity;
PRI-2201

PRI-2201

phenylboronic acid
98-80-6

phenylboronic acid

A

C33H43BO3
934338-46-2

C33H43BO3

B

calcipotriene
112965-21-6

calcipotriene

Conditions
ConditionsYield
In acetone for 3h; Purification / work up;
PRI-2205
113082-99-8

PRI-2205

calcipotriene
112965-21-6

calcipotriene

Conditions
ConditionsYield
With 9-acetylanthracene In acetone at 10℃; Product distribution / selectivity; UV-irradiation;
C27H40O3
934338-38-2

C27H40O3

A

(5Z,7E,22E,24R)-24-cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1β,3β,24-triol

(5Z,7E,22E,24R)-24-cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1β,3β,24-triol

B

calcipotriene
112965-21-6

calcipotriene

Conditions
ConditionsYield
With 9-acetylanthracene In acetone at 10℃; Product distribution / selectivity; UV-irradiation;
C35H60O2Si2
590366-68-0

C35H60O2Si2

calcipotriene
112965-21-6

calcipotriene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: bis(cyclohexanyl)borane; diethylzinc; (2R)-3-exo-(dimethylamino)isoborneol / hexane / -20 - 0 °C
1.2: 0 °C
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C
View Scheme
[(2Z)-2-[(3S,5R)-3,5-bis(tert-butyldimethylsilanyloxy)-2-methylenecyclohexylidene]ethyl]diphenylphosphine oxide
81522-68-1

[(2Z)-2-[(3S,5R)-3,5-bis(tert-butyldimethylsilanyloxy)-2-methylenecyclohexylidene]ethyl]diphenylphosphine oxide

calcipotriene
112965-21-6

calcipotriene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: n-hexyllithium / -78 °C
2.1: bis(cyclohexanyl)borane; diethylzinc; (2R)-3-exo-(dimethylamino)isoborneol / hexane / -20 - 0 °C
2.2: 0 °C
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C
View Scheme
tert-butyl[(1S)-1-cyclopropyl-2-[(R)-4-methylbenzenesulfinyl]ethoxy]dimethylsilane

tert-butyl[(1S)-1-cyclopropyl-2-[(R)-4-methylbenzenesulfinyl]ethoxy]dimethylsilane

calcipotriene
112965-21-6

calcipotriene

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: 2,4,6-trimethyl-pyridine; trifluoroacetic anhydride / acetonitrile / 0.17 h / 30 °C / Inert atmosphere
1.2: 0.08 h
2.1: dichloromethane / 0.17 h / -50 °C / Inert atmosphere
3.1: N-ethyl-N,N-diisopropylamine / water; acetonitrile
4.1: hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide / isopropyl alcohol / 20 - 30 °C
5.1: potassium hexamethylsilazane / tetrahydrofuran / 2 h / -50 °C / Inert atmosphere
6.1: triethylamine; anthracene / toluene / 1.5 h / 20 °C / UV-irradiation
6.2: 1 h / 60 °C
View Scheme
Multi-step reaction with 6 steps
1.1: 2,4,6-trimethyl-pyridine; trifluoroacetic anhydride / acetonitrile / 0.17 h / 30 °C / Inert atmosphere
1.2: 0.08 h
2.1: dichloromethane / 0.17 h / -50 °C / Inert atmosphere
3.1: lithium diisopropyl amide / tetrahydrofuran; N,N-dimethyl-formamide / 0.08 h
3.2: 2 h / 30 °C
4.1: 3-chloro-benzenecarboperoxoic acid / acetonitrile / 0 - 20 °C
5.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -30 °C / Inert atmosphere
6.1: triethylamine; anthracene / toluene / 1.5 h / 20 °C / UV-irradiation
6.2: 1 h / 60 °C
View Scheme
(1S,2R)-1-cyclopropyl-2-(p-tolylsulfoxy)-O-methoxy methyl ether

(1S,2R)-1-cyclopropyl-2-(p-tolylsulfoxy)-O-methoxy methyl ether

calcipotriene
112965-21-6

calcipotriene

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: potassium carbonate; acetic anhydride / acetonitrile / 0.5 h / 50 °C / Inert atmosphere
1.2: 0.17 h
2.1: triethylamine / acetonitrile / 0.5 h / 0 °C / Inert atmosphere
3.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.08 h / Inert atmosphere
3.2: 2 h / 30 °C
4.1: 3-chloro-benzenecarboperoxoic acid / acetonitrile / 0 - 20 °C
5.1: sodium hexamethyldisilazane / diethyl ether / 3 h / -80 °C / Inert atmosphere
6.1: triethylamine; anthracene / toluene / 1.5 h / UV-irradiation
6.2: 1 h / 60 °C
6.3: 3 h / 20 °C
View Scheme
(S)-2-{[(benzyloxy)carbonyl]oxy}-2-cyclopropylethan-1-ol

(S)-2-{[(benzyloxy)carbonyl]oxy}-2-cyclopropylethan-1-ol

calcipotriene
112965-21-6

calcipotriene

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / -30 °C / Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C
3.1: 3-chloro-benzenecarboperoxoic acid / acetonitrile / 2 h / 20 - 50 °C
4.1: lithium hexamethyldisilazane / tetrahydrofuran; 1,4-dioxane / 2 h / -20 °C / Inert atmosphere
5.1: triethylamine; anthracene / toluene / 1.5 h / UV-irradiation
5.2: 1 h / 60 °C
5.3: 3 h / 20 °C / 760.05 Torr
View Scheme
(S)-2-[(tert-butyldimethylsilyl)oxy]-2-cyclopropylethan-1-ol

(S)-2-[(tert-butyldimethylsilyl)oxy]-2-cyclopropylethan-1-ol

calcipotriene
112965-21-6

calcipotriene

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: dichloromethane / 0.17 h / -50 °C / Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine / water; acetonitrile
3.1: hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide / isopropyl alcohol / 20 - 30 °C
4.1: potassium hexamethylsilazane / tetrahydrofuran / 2 h / -50 °C / Inert atmosphere
5.1: triethylamine; anthracene / toluene / 1.5 h / 20 °C / UV-irradiation
5.2: 1 h / 60 °C
View Scheme
Multi-step reaction with 5 steps
1.1: dichloromethane / 0.17 h / -50 °C / Inert atmosphere
2.1: lithium diisopropyl amide / tetrahydrofuran; N,N-dimethyl-formamide / 0.08 h
2.2: 2 h / 30 °C
3.1: 3-chloro-benzenecarboperoxoic acid / acetonitrile / 0 - 20 °C
4.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -30 °C / Inert atmosphere
5.1: triethylamine; anthracene / toluene / 1.5 h / 20 °C / UV-irradiation
5.2: 1 h / 60 °C
View Scheme
(S)-2-cyclopropyl-2-(methoxymethoxy)ethan-1-ol

(S)-2-cyclopropyl-2-(methoxymethoxy)ethan-1-ol

calcipotriene
112965-21-6

calcipotriene

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: triethylamine / acetonitrile / 0.5 h / 0 °C / Inert atmosphere
2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.08 h / Inert atmosphere
2.2: 2 h / 30 °C
3.1: 3-chloro-benzenecarboperoxoic acid / acetonitrile / 0 - 20 °C
4.1: sodium hexamethyldisilazane / diethyl ether / 3 h / -80 °C / Inert atmosphere
5.1: triethylamine; anthracene / toluene / 1.5 h / UV-irradiation
5.2: 1 h / 60 °C
5.3: 3 h / 20 °C
View Scheme
(1S)-2-{[(benzyloxy)carbonyl]oxy}-2-cyclopropylethyl trifluoromethanesulfonate

(1S)-2-{[(benzyloxy)carbonyl]oxy}-2-cyclopropylethyl trifluoromethanesulfonate

calcipotriene
112965-21-6

calcipotriene

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C
2.1: 3-chloro-benzenecarboperoxoic acid / acetonitrile / 2 h / 20 - 50 °C
3.1: lithium hexamethyldisilazane / tetrahydrofuran; 1,4-dioxane / 2 h / -20 °C / Inert atmosphere
4.1: triethylamine; anthracene / toluene / 1.5 h / UV-irradiation
4.2: 1 h / 60 °C
4.3: 3 h / 20 °C / 760.05 Torr
View Scheme
all-cis-6,9,12-octadecatrienoic acid
506-26-3

all-cis-6,9,12-octadecatrienoic acid

calcipotriene
112965-21-6

calcipotriene

A

calcipotriol 24-γ-linolenoate

calcipotriol 24-γ-linolenoate

B

calcipotriol bis(γ-linolenoate)

calcipotriol bis(γ-linolenoate)

Conditions
ConditionsYield
With 4-(dimethylamino)pypiridine; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 3h;
(9Z,12Z,15Z)-octadeca-9-12,15-trienoic acid
463-40-1

(9Z,12Z,15Z)-octadeca-9-12,15-trienoic acid

calcipotriene
112965-21-6

calcipotriene

A

calcipotriol 24-linolenoate

calcipotriol 24-linolenoate

B

calcipotriol dilinolenoate

calcipotriol dilinolenoate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 3h;
(9Z,12Z,15Z)-octadeca-9-12,15-trienoic acid
463-40-1

(9Z,12Z,15Z)-octadeca-9-12,15-trienoic acid

calcipotriene
112965-21-6

calcipotriene

calcipotriol mono-linoleic ester

calcipotriol mono-linoleic ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 3h;
calcipotriene
112965-21-6

calcipotriene

calcipotriol monohydrate

calcipotriol monohydrate

Conditions
ConditionsYield
With water In ethyl acetate
With ammonia; water at 25 - 40℃; for 12 - 50h; pH=> 7; Product distribution / selectivity;
calcipotriene
112965-21-6

calcipotriene

calci-dioxole
1201658-10-7

calci-dioxole

Conditions
ConditionsYield
With oxygen; methylene blue In methanol at 20℃; Photolysis;
calcipotriene
112965-21-6

calcipotriene

calci-Cl

calci-Cl

Conditions
ConditionsYield
With hydrogenchloride; oxygen In ethanol at 20℃;
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