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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

hydroxychloroquine

Cas:118-42-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------

High purity 118-42-3 Hydroxychloroquine

Cas:118-42-3

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol

Cas:118-42-3

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Hydroxychloroquine

Cas:118-42-3

Min.Order:1

Negotiable

Type:Other

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&D b

Hydroxychloroquine/ LIDE PHARMA- Factory supply / Best price

Cas:118-42-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol CAS 118-42-3

Cas:118-42-3

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 118-42-3 with competitive price

Cas:118-42-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Item Name Hydroxychloroquine CAS NO 118-42-3 Apparence White Powder Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:drum Applic

Hydroxychloroquine

Cas:118-42-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:White powder Storage:Room temperature Package:25kg/drum Application:Synthetic anti-malaria Chemicals Transportation:Express/Sea/Air Port:Any port in china

High Purity Hydroxychloroquine CAS:118-42-3

Cas:118-42-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Ethanol,2-[[4-[(7-chloro-4-quinolinyl)amino]pentyl]ethylamino]- 118-42-3

Cas:118-42-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

1.Strong backup of factory:hign ability,favorable quality and competitive price. 2.Most of our products in catalogue are have stock. 3.Free sample could be provided. 4.Suitable package to protect the product the product quality. 5.the lead time

Hydroxychloroquine

Cas:118-42-3

Min.Order:1 Kilogram

FOB Price: $2000.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Hydroxychloroquine CAS:118-42-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermed

Hydroxychloroquine CAS:118-42-3

Cas:118-42-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Ethanol,2-[[4-[(7-chloro-4-quinolinyl)amino]pentyl]ethylamino]-

Cas:118-42-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol

Cas:118-42-3

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Changchun Artel lmport and Export trade company

Melting point 89-91° Boiling point 516.7±50.0 °C(Predicted) density 1.1438 (rough estimate) refractive index 1.5790 (

Hydroxychloroquine

Cas:118-42-3

Min.Order:100 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Ethanol,2-[[4-[(7-chloro-4-quinolinyl)amino]pentyl]ethylamino]-

Cas:118-42-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

HYDROXYCHLOROQUINE

Cas:118-42-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Ethanol,2-[[4-[(7-chloro-4-quinolinyl)amino]pentyl]ethylamino]-

Cas:118-42-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hefei Zhaobo Technology Co., Ltd.

Our Advantages Production: Advanced chemical equipment with years of experience.Staffs for producing various extract products. Quality Control:A complete set of Testing Professional and Analysis Equipment ensures the Quality Requirements and Speci

Hydroxychloroquine CAS 118-42-3

Cas:118-42-3

Min.Order:1 Kilogram

FOB Price: $150.0 / 180.0

Type:Trading Company

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Ethanol,2-[[4-[(7-chloro-4-quinolinyl)amino]pentyl]ethylamino]-

Cas:118-42-3

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol

Cas:118-42-3

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol

Cas:118-42-3

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

hydroxychloroquine

Cas:118-42-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Buy Top Quality2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol

Cas:118-42-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Hydroxychloroquine

Cas:118-42-3

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol

Cas:118-42-3

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol

Cas:118-42-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol

Cas:118-42-3

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol

Cas:118-42-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol

Cas:118-42-3

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Synthetic route

Plaquenil

Plaquenil

hydroxychloroquine
118-42-3

hydroxychloroquine

Conditions
ConditionsYield
With sodium hydroxide In water at 20℃; Cooling with ice;97.6%
With sodium hydroxide In water; ethyl acetate at 0℃; for 1h;91%
With sodium hydroxide In water at 0℃; for 0.5h;91%
With ammonia In chloroform at 20℃; for 1h; pH=9;90%
With ammonium hydroxide In water
4,7-dichloroquinoline
86-98-6

4,7-dichloroquinoline

rac-5--2-pentanamine
69559-11-1

rac-5--2-pentanamine

hydroxychloroquine
118-42-3

hydroxychloroquine

Conditions
ConditionsYield
With KF/Al2O3 In toluene at 110 - 120℃; for 12h; Reagent/catalyst; Solvent; Temperature; Large scale;94%
With sodium hydroxide at 140℃; for 6h; pH=7 - Ca. 8; Temperature; pH-value; Inert atmosphere;91.2%
at 78 - 130℃; for 8.33333h; Temperature; Inert atmosphere;90.3%
2,3-dichloroquinoline
613-18-3

2,3-dichloroquinoline

rac-5--2-pentanamine
69559-11-1

rac-5--2-pentanamine

hydroxychloroquine
118-42-3

hydroxychloroquine

Conditions
ConditionsYield
In ethylene glycol at 90 - 100℃; for 24h; Temperature; Large scale;92.3%
hydroxychloroquine hydrochloride

hydroxychloroquine hydrochloride

hydroxychloroquine
118-42-3

hydroxychloroquine

Conditions
ConditionsYield
With sodium t-butanolate In isopropyl alcohol Solvent; Reagent/catalyst;88.3%
7-chloro-4-fluoroquinoline
103526-68-7

7-chloro-4-fluoroquinoline

rac-5--2-pentanamine
69559-11-1

rac-5--2-pentanamine

hydroxychloroquine
118-42-3

hydroxychloroquine

Conditions
ConditionsYield
In acetonitrile for 3h;88.3%
4,7-dichloroquinoline
86-98-6

4,7-dichloroquinoline

(+-)-2--ethanol

(+-)-2--ethanol

hydroxychloroquine
118-42-3

hydroxychloroquine

Conditions
ConditionsYield
With phenol at 125 - 130℃;
With potassium iodide; phenol
5-(N-ethyl-N-2-hydroxyethylamine)-2-pentanone
74509-79-8

5-(N-ethyl-N-2-hydroxyethylamine)-2-pentanone

hydroxychloroquine
118-42-3

hydroxychloroquine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate; hydroxylamine / tetrahydrofuran / 0.17 h / 100 °C / Inert atmosphere; Flow reactor
2: hydrogen / tetrahydrofuran / 4 h / 80 °C / 7500.75 Torr / Inert atmosphere; Flow reactor
3: potassium carbonate; triethylamine / ethanol / 6 h / 125 °C / Inert atmosphere; Flow reactor
View Scheme
5-iodo-2-pentanone
3695-29-2

5-iodo-2-pentanone

hydroxychloroquine
118-42-3

hydroxychloroquine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium carbonate / tetrahydrofuran / 0.17 h / 80 - 100 °C / Flow reactor; Inert atmosphere
2: potassium carbonate; hydroxylamine / tetrahydrofuran / 0.17 h / 100 °C / Inert atmosphere; Flow reactor
3: hydrogen / tetrahydrofuran / 4 h / 80 °C / 7500.75 Torr / Inert atmosphere; Flow reactor
4: potassium carbonate; triethylamine / ethanol / 6 h / 125 °C / Inert atmosphere; Flow reactor
View Scheme
Multi-step reaction with 3 steps
1.1: potassium carbonate / tetrahydrofuran / Flow reactor; Inert atmosphere
1.2: 100 °C / Flow reactor; Inert atmosphere
2.1: hydrogen / tetrahydrofuran / 80 °C / 7500.75 Torr
3.1: potassium carbonate; triethylamine / ethanol / 6 h / 125 °C / 775.74 Torr / Inert atmosphere
View Scheme
3-acetyl-2-oxo-4,5-dihydrofuran
517-23-7

3-acetyl-2-oxo-4,5-dihydrofuran

hydroxychloroquine
118-42-3

hydroxychloroquine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: hydrogen iodide / water / 0.08 h / 80 °C / 2250.23 Torr / Inert atmosphere; Flow reactor
2: potassium carbonate / tetrahydrofuran / 0.17 h / 80 - 100 °C / Flow reactor; Inert atmosphere
3: potassium carbonate; hydroxylamine / tetrahydrofuran / 0.17 h / 100 °C / Inert atmosphere; Flow reactor
4: hydrogen / tetrahydrofuran / 4 h / 80 °C / 7500.75 Torr / Inert atmosphere; Flow reactor
5: potassium carbonate; triethylamine / ethanol / 6 h / 125 °C / Inert atmosphere; Flow reactor
View Scheme
Multi-step reaction with 4 steps
1.1: sodium hydrogencarbonate; hydrogen iodide / water / 80 °C / Inert atmosphere
2.1: potassium carbonate / tetrahydrofuran / Flow reactor; Inert atmosphere
2.2: 100 °C / Flow reactor; Inert atmosphere
3.1: hydrogen / tetrahydrofuran / 80 °C / 7500.75 Torr
4.1: potassium carbonate; triethylamine / ethanol / 6 h / 125 °C / 775.74 Torr / Inert atmosphere
View Scheme
4,7-dichloroquinoline
86-98-6

4,7-dichloroquinoline

hydroxychloroquine
118-42-3

hydroxychloroquine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 19 h / 110 - 130 °C
2: sodium t-butanolate / isopropyl alcohol
View Scheme
Multi-step reaction with 2 steps
1: cetyltrimethylammonim bromide; potassium fluoride / acetonitrile / 2 h / 80 °C / Inert atmosphere
2: acetonitrile / 3 h
View Scheme
rac-5--2-pentanamine
69559-11-1

rac-5--2-pentanamine

hydroxychloroquine
118-42-3

hydroxychloroquine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 19 h / 110 - 130 °C
2: sodium t-butanolate / isopropyl alcohol
View Scheme
hydroxychloroquine
118-42-3

hydroxychloroquine

Plaquenil

Plaquenil

Conditions
ConditionsYield
With sulfuric acid In water at 15 - 55℃; for 5h; Temperature; Solvent;98%
With sulfuric acid In ethanol at 5 - 10℃; for 12h; Large scale;98.6%
With sulfuric acid In ethanol at 0 - 30℃; for 5h; pH=4.5 - 5.5; Solvent;96.1%
1-ethenesulfonyl-piperidine
66089-45-0

1-ethenesulfonyl-piperidine

hydroxychloroquine
118-42-3

hydroxychloroquine

N4-(7-chloroquinolin-4-yl)-N1-ethyl-N1-(2-(2-(piperidin-1-ylsulfonyl)ethoxy)ethyl)pentane-1,4-diamine

N4-(7-chloroquinolin-4-yl)-N1-ethyl-N1-(2-(2-(piperidin-1-ylsulfonyl)ethoxy)ethyl)pentane-1,4-diamine

Conditions
ConditionsYield
Stage #1: hydroxychloroquine With silver(I) acetate; 1,2-bis-(diphenylphosphino)ethane In N,N-dimethyl-formamide at -20℃; Inert atmosphere;
Stage #2: 1-ethenesulfonyl-piperidine With potassium hexamethylsilazane In tetrahydrofuran; N,N-dimethyl-formamide at -20℃; for 9h; Inert atmosphere; regioselective reaction;
92%
2,2,2-trifluoroethyl benzoate
1579-72-2

2,2,2-trifluoroethyl benzoate

hydroxychloroquine
118-42-3

hydroxychloroquine

2-((4-((7-chloroquinolin-4-yl)amino)pentyl)(ethyl)amino)ethyl benzoate

2-((4-((7-chloroquinolin-4-yl)amino)pentyl)(ethyl)amino)ethyl benzoate

Conditions
ConditionsYield
With (μ-oxo)bis[(1,2-ethanediamino-N,N'-bis(salicylidene))iron(III)] In toluene at 120℃; for 5h; Inert atmosphere; Schlenk technique; chemoselective reaction;89%
hydroxychloroquine
118-42-3

hydroxychloroquine

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

C22H28ClN5O2

C22H28ClN5O2

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 20℃; for 4h; Inert atmosphere; Schlenk technique;75%
hydroxychloroquine
118-42-3

hydroxychloroquine

C18H25ClN6

C18H25ClN6

Conditions
ConditionsYield
With diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide for 48h; Inert atmosphere;70%
With diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 20℃; for 48h; Inert atmosphere;
hydroxychloroquine
118-42-3

hydroxychloroquine

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

rac-N1-(2-((tert-butyldimethylsilyl)oxy)ethyl)-N4-(7-chloroquinolin-4-yl)-N1-ethylpentane-1,4-diamine

rac-N1-(2-((tert-butyldimethylsilyl)oxy)ethyl)-N4-(7-chloroquinolin-4-yl)-N1-ethylpentane-1,4-diamine

Conditions
ConditionsYield
With triethylamine In 1,2-dichloro-ethane at 20℃; for 48h;68%
hydroxychloroquine
118-42-3

hydroxychloroquine

(R)-Hydroxychloroquine

(R)-Hydroxychloroquine

Conditions
ConditionsYield
Stage #1: hydroxychloroquine With (S)-Malic acid In ethanol; ethyl acetate at 0 - 5℃; for 0.5h;
Stage #2: With sodium methylate In methanol at 0 - 20℃; for 0.5h; Reagent/catalyst; Solvent;
64%
hydroxychloroquine
118-42-3

hydroxychloroquine

(S)-Hydroxychloroquine

(S)-Hydroxychloroquine

Conditions
ConditionsYield
Stage #1: hydroxychloroquine With D-Malic acid In ethanol; ethyl acetate at 0 - 5℃; for 0.5h;
Stage #2: With sodium methylate In methanol at 0 - 20℃; for 0.5h; Reagent/catalyst; Solvent;
56%
hydroxychloroquine
118-42-3

hydroxychloroquine

acrylonitrile
107-13-1

acrylonitrile

3-(2-((4-((7-chloroquinolin-4-yl)amino)pentyl)(ethyl)amino)ethoxy)propanenitrile
1606176-75-3

3-(2-((4-((7-chloroquinolin-4-yl)amino)pentyl)(ethyl)amino)ethoxy)propanenitrile

Conditions
ConditionsYield
With n-butyllithium; copper(I) 2-hydroxy-3-methylbenzoate; 1,2-bis-(diphenylphosphino)ethane In hexane; N,N-dimethyl-formamide at 20℃; for 3h; Michael Addition; Inert atmosphere; chemoselective reaction;56%
hydroxychloroquine
118-42-3

hydroxychloroquine

6‐(3‐methyl‐1,4‐dioxo‐1,4‐dihydronaphthalen‐2‐yl)hexanoic acid
84978-05-2

6‐(3‐methyl‐1,4‐dioxo‐1,4‐dihydronaphthalen‐2‐yl)hexanoic acid

2-[4-[(7-chloro-4-quinolyl)amino]pentyl(ethyl)amino]ethyl-6-[2-(3-methyl)-1,4-naphthoquinolyl]hexanoate

2-[4-[(7-chloro-4-quinolyl)amino]pentyl(ethyl)amino]ethyl-6-[2-(3-methyl)-1,4-naphthoquinolyl]hexanoate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 24h;53%
(9Z,12Z,15Z)-octadeca-9-12,15-trienoic acid
463-40-1

(9Z,12Z,15Z)-octadeca-9-12,15-trienoic acid

hydroxychloroquine
118-42-3

hydroxychloroquine

hydroxychloroquine linolenate

hydroxychloroquine linolenate

Conditions
ConditionsYield
Stage #1: (9Z,12Z,15Z)-octadeca-9-12,15-trienoic acid With 4-methyl-morpholine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 0.5h; Cooling with ice; Inert atmosphere;
Stage #2: hydroxychloroquine In dichloromethane at 20℃; for 12h; Reagent/catalyst; Inert atmosphere;
52.5%
4,7-dichloroquinoline
86-98-6

4,7-dichloroquinoline

hydroxychloroquine
118-42-3

hydroxychloroquine

C27H30Cl2N4O

C27H30Cl2N4O

Conditions
ConditionsYield
With potassium tert-butylate at 110 - 115℃; for 4h;50.3%
tert-Butyl acrylate
1663-39-4

tert-Butyl acrylate

hydroxychloroquine
118-42-3

hydroxychloroquine

C25H38ClN3O3

C25H38ClN3O3

Conditions
ConditionsYield
With silver(I) acetate; sodium hexamethyldisilazane; 1,2-bis-(diphenylphosphino)ethane In N,N-dimethyl-formamide at -20℃; chemoselective reaction;33%
succinic acid anhydride
108-30-5

succinic acid anhydride

hydroxychloroquine
118-42-3

hydroxychloroquine

hydroxychloroquine-succinate
1057094-59-3

hydroxychloroquine-succinate

Conditions
ConditionsYield
With dmap; sodium sulfate In pyridine at 20℃; for 6h;
hydroxychloroquine
118-42-3

hydroxychloroquine

2-cyanoethyl N,N,N′,N′-tetraisopropylphosphordiamidite

2-cyanoethyl N,N,N′,N′-tetraisopropylphosphordiamidite

hydroxychloroquine phosphoramidite

hydroxychloroquine phosphoramidite

Conditions
ConditionsYield
With 1H-tetrazole In dichloromethane; acetonitrile at 20℃; for 1.5 - 2h;
hydroxychloroquine
118-42-3

hydroxychloroquine

C18H24ClN3O

C18H24ClN3O

Conditions
ConditionsYield
pH=8; Electrochemical reaction;
hydroxychloroquine
118-42-3

hydroxychloroquine

rac-(9-(7-chloroquinolin-4-yl)-14-ethyl-16-hydroxy-10-methyl-3,8-dioxo-7-oxa-2,9,14-triazahexadecane-1,1-diyl)diphosphonic acid

rac-(9-(7-chloroquinolin-4-yl)-14-ethyl-16-hydroxy-10-methyl-3,8-dioxo-7-oxa-2,9,14-triazahexadecane-1,1-diyl)diphosphonic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triethylamine / 1,2-dichloro-ethane / 48 h / 20 °C
2.1: potassium carbonate / dichloromethane / 2 h / 0 °C
2.2: 36 h / 0 - 20 °C
View Scheme
(4-biphenylyl)acetic acid
5728-52-9

(4-biphenylyl)acetic acid

hydroxychloroquine
118-42-3

hydroxychloroquine

HBA

HBA

Conditions
ConditionsYield
Stage #1: (4-biphenylyl)acetic acid With 1,1'-carbonyldiimidazole In chloroform at 20℃; for 2 - 5h;
Stage #2: hydroxychloroquine In chloroform at 70℃; for 10 - 12h; Reflux;
hydroxychloroquine
118-42-3

hydroxychloroquine

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
53-86-1

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

HIN

HIN

Conditions
ConditionsYield
Stage #1: [1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid With 1,1'-carbonyldiimidazole In chloroform at 20℃; for 2 - 5h;
Stage #2: hydroxychloroquine In chloroform at 70℃; for 10 - 12h; Reflux;
hydroxychloroquine
118-42-3

hydroxychloroquine

aceclofenac
89796-99-6

aceclofenac

HA

HA

Conditions
ConditionsYield
Stage #1: aceclofenac With 1,1'-carbonyldiimidazole In chloroform at 20℃; for 2 - 5h;
Stage #2: hydroxychloroquine In chloroform at 70℃; for 10 - 12h; Reflux;
[2-(2,6-dichloroanilino)phenyl]acetic acid
15307-86-5

[2-(2,6-dichloroanilino)phenyl]acetic acid

hydroxychloroquine
118-42-3

hydroxychloroquine

HD

HD

Conditions
ConditionsYield
Stage #1: [2-(2,6-dichloroanilino)phenyl]acetic acid With 1,1'-carbonyldiimidazole In chloroform at 20℃; for 2 - 5h;
Stage #2: hydroxychloroquine In chloroform at 70℃; for 10 - 12h; Reflux;
hydroxychloroquine
118-42-3

hydroxychloroquine

licofelone
156897-06-2

licofelone

HL

HL

Conditions
ConditionsYield
Stage #1: licofelone With 1,1'-carbonyldiimidazole In chloroform at 20℃; for 2 - 5h;
Stage #2: hydroxychloroquine In chloroform at 70℃; for 10 - 12h; Reflux;

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