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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price in China. If you are looking for the product’s supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product specifica

Esomeprazole

Cas:119141-88-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Chongqing Lummy Long Yu Pharmaceutical Co. ,Ltd

Product technology and quality stability,perennial production,to meet the supply demand. Quality: 1. Order products, before delivery, according to customer needs, we will provide such as COA, or customer specified demand quality indicators. 2.

Esomeprazole

Cas:119141-88-7

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay 99.9%min 99.9% Hangzhou Dingyan Chem is a leading manufacturer and supplier of che

High quality 119141-88-7 Esomeprazole Sodium

Cas:119141-88-7

Min.Order:1 Kilogram

FOB Price: $1300.0 / 1600.0

Type:Trading Company

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu

Esomeprazole 119141-88-7 API

Cas:119141-88-7

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Stable stock and competitive price Appearance:White powder Storage:Room temperature with sealed well Package:1KG 5KG 25KG Application:As Pharm raw material Transportation:By Courier,Sea or air Port:Shanghai

Esomeprazole

Cas:119141-88-7

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hebei yanxi chemical co.,LTD.

Hebei yanxi chemical co., LTD is a professional research, development and production Cyromazine、lead diacetate trihydrate /Lead acetate trihydrateC、 2-phenylacetamide 、 4-Aminophenyl-1-phenethylpiperidine 、Citric acid monohydrate 、 Citric acid/c

1H-Benzimidazole,6-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-

Cas:119141-88-7

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Manufacturers

inquiry

Henan Allgreen Chemical Co.,Ltd

T he company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality service Appearance:white pow

Esomeprazole

Cas:119141-88-7

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Esomeprazole 119141-88-7 GMP Manufacturer

Cas:119141-88-7

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name:Esomeprazole CAS NO:119141-88-7 Molecular formula:C17H19N3O3S Molecular weight:345.4161 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability

Esomeprazole/CAS:119141-88-7/Raw material supply

Cas:119141-88-7

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Esomeprazole/ LIDE PHARMA- Factory supply / Best price

Cas:119141-88-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Esomeprazole Basic information Product Name: Esomeprazole Synonyms: Esomeprazole(Na、Mg);(5-methoxy-1H-benzimidazol-2-yl)[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]

Esomeprazole 119141-88-7

Cas:119141-88-7

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu

Esomeprazole CAS No. 119141-88-7

Cas:119141-88-7

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 119141-88-7 with best quality

Cas:119141-88-7

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

Esomeprazole For Treatment Of Esophagitis

Cas:119141-88-7

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1H-Benzimidazole,6-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]- 119141-88-7

Cas:119141-88-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Qingdao Beluga Import and Export Co., LTD

Esomeprazole CAS:119141-88-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediat

Esomeprazole CAS:119141-88-7

Cas:119141-88-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1H-Benzimidazole,6-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-

Cas:119141-88-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,

Esomeprazole CAS NO.119141-88-7

Cas:119141-88-7

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several

Esomeprazole cas:119141-88-7

Cas:119141-88-7

Min.Order:25 Gram

FOB Price: $90.0 / 100.0

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1H-Benzimidazole,6-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-

Cas:119141-88-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Esomeprazole

Cas:119141-88-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Esomeprazole

Cas:119141-88-7

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Triumph International Development Limilted

Appearance:white crystalline powder Storage:Sealed in dry,Room Temperature Application:(-)-Omeprazole can be used to treat migraine. Esomeprazole is used to treat certain stomach and esophagus problems (such as acid reflux, ulcers). It w

Esomeprazole

Cas:119141-88-7

Min.Order:25 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Esomeprazole

Cas:119141-88-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Esomeprazole

Cas:119141-88-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi New nine Material Technology Co., Ltd.

Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality control system,assigning specific persons in charge of each part of production,from raw material purchase to assembly. 2 Professional R&D

Esomeprazole CAS NO.119141-88-7

Cas:119141-88-7

Min.Order:10 Gram

FOB Price: $5.0 / 10.0

Type:Trading Company

inquiry

Hangzhou Think Chemical Co. Ltd

Product Name:Esomeprazole Batch No:20201020 Analysis Date:2020-10-20 Retest Date:2022-10-19 HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years

Esomeprazole(Sodium)

Cas:119141-88-7

Min.Order:25 Kilogram

FOB Price: $340.0 / 350.0

Type:Other

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

Esomeprazole

Cas:119141-88-7

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Esomeprazole

Cas:119141-88-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Synthetic route

omeprazole sulfide
73590-85-9

omeprazole sulfide

esomeprazole
119141-88-7

esomeprazole

Conditions
ConditionsYield
Stage #1: omeprazole sulfide With titanium(IV) isopropylate; diethyl (2S,3S)-tartrate In water; toluene at 65 - 70℃; for 0.833333h;
Stage #2: With Cumene hydroperoxide; N-ethyl-N,N-diisopropylamine In water; toluene at 2 - 5℃;
99.2%
With C23H48NO(1+)*2H(1+)*O40PW12(3-); dihydrogen peroxide; sodium hydrogencarbonate; (1S,2S)-cyclohexane-1,2-diammonium 2,3-dihydroxysuccinate In water; acetone at 28℃; for 15h; Temperature;95.6%
With dihydrogen peroxide In water at 25℃; for 3h; Solvent;95%
S-omeprazole*(S)-[1.1'-binaphthalen]-2.2'-diol inclusion complex

S-omeprazole*(S)-[1.1'-binaphthalen]-2.2'-diol inclusion complex

esomeprazole
119141-88-7

esomeprazole

Conditions
ConditionsYield
With sodium hydroxide In water; toluene pH=11.5 - 12.0; Product distribution / selectivity;99%
With sodium hydroxide In tert-butyl methyl ether; water pH=11.3; Product distribution / selectivity;99%
With sodium hydroxide; water In toluene pH=11.5 - 12; Product distribution / selectivity;99%
(S)-omeprazole N-benzylcinchoninium salt

(S)-omeprazole N-benzylcinchoninium salt

A

N-benzylcinchoninium chloride

N-benzylcinchoninium chloride

B

esomeprazole
119141-88-7

esomeprazole

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water at 0℃; for 1h; pH=3 - 3.5; Product distribution / selectivity;A 99%
B n/a
(S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole [(S)-1,1,2-triphenyl-1,2-ethanediol]2

(S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole [(S)-1,1,2-triphenyl-1,2-ethanediol]2

esomeprazole
119141-88-7

esomeprazole

Conditions
ConditionsYield
Stage #1: (S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole [(S)-1,1,2-triphenyl-1,2-ethanediol]2 With sodium hydroxide In water; toluene at 80℃;
Stage #2: With acetic acid In water; toluene at 0℃; for 2h; Product distribution / selectivity;
98%
Stage #1: (S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole [(S)-1,1,2-triphenyl-1,2-ethanediol]2 With potassium hydroxide In water; toluene at 80℃;
Stage #2: With acetic acid In water; toluene at 0℃; for 2h; Product distribution / selectivity;
95%
Stage #1: (S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole [(S)-1,1,2-triphenyl-1,2-ethanediol]2 With sodium hydroxide In dichloromethane; water Heating / reflux;
Stage #2: With acetic acid In dichloromethane; water at 0℃; for 1h; Product distribution / selectivity;
84%
(S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole [(S)-1,1,2-triphenyl-1,2-ethanediol]2

(S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole [(S)-1,1,2-triphenyl-1,2-ethanediol]2

A

(S)-1,1,2-triphenyl-1,2-ethanediol
108998-83-0

(S)-1,1,2-triphenyl-1,2-ethanediol

B

esomeprazole
119141-88-7

esomeprazole

Conditions
ConditionsYield
Stage #1: (S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole [(S)-1,1,2-triphenyl-1,2-ethanediol]2 With sodium hydroxide In dichloromethane; water Heating / reflux;
Stage #2: With ammonium acetate In dichloromethane; water at 0℃; for 2h; Product distribution / selectivity;
A n/a
B 96%
C9H12ClMgNO

C9H12ClMgNO

(S)-5-methoxy-1H-benzimidazole-2-sulfinic acid-(S)-1-phenyl ethylester

(S)-5-methoxy-1H-benzimidazole-2-sulfinic acid-(S)-1-phenyl ethylester

esomeprazole
119141-88-7

esomeprazole

Conditions
ConditionsYield
In tetrahydrofuran at -5 - 5℃; for 3h; Temperature;92.3%
In tetrahydrofuran at -5 - 0℃; for 3h; Temperature;733.2 g
(S)-5-methoxy-1H-benzimidazole-2-sulfinic acid-(S)-1-phenyl ethylester

(S)-5-methoxy-1H-benzimidazole-2-sulfinic acid-(S)-1-phenyl ethylester

(chloromethyl)-4-methoxy-3,5-dimethylpyridine
84006-10-0

(chloromethyl)-4-methoxy-3,5-dimethylpyridine

esomeprazole
119141-88-7

esomeprazole

Conditions
ConditionsYield
Stage #1: (chloromethyl)-4-methoxy-3,5-dimethylpyridine With iodine; magnesium In tetrahydrofuran at 30℃; for 5h; Inert atmosphere;
Stage #2: (S)-5-methoxy-1H-benzimidazole-2-sulfinic acid-(S)-1-phenyl-ethylester In tetrahydrofuran at -5 - 0℃; for 3h; stereoselective reaction;
92.3%
(S)-5-methoxy-1H-benzimidazole-2-sulfinic acid-(S)-1-phenyl ethylester

(S)-5-methoxy-1H-benzimidazole-2-sulfinic acid-(S)-1-phenyl ethylester

C8H10ClMgNO

C8H10ClMgNO

esomeprazole
119141-88-7

esomeprazole

Conditions
ConditionsYield
In tetrahydrofuran at -5 - 0℃; Reagent/catalyst; Temperature;92.3%
(S)-5-methoxy-1H-benzimidazole-2-sulfinic acid-(S)-1-phenyl ethylester

(S)-5-methoxy-1H-benzimidazole-2-sulfinic acid-(S)-1-phenyl ethylester

C9H12ClNOZn

C9H12ClNOZn

esomeprazole
119141-88-7

esomeprazole

Conditions
ConditionsYield
In tetrahydrofuran at -15 - 0℃; for 1h; stereoselective reaction;90.2%
omeprazole sodium

omeprazole sodium

esomeprazole
119141-88-7

esomeprazole

Conditions
ConditionsYield
Stage #1: omeprazole sodium With titanium(IV) isopropylate; diethyl (2S,3S)-tartrate; water; triethylamine In acetone at 35 - 40℃; Large scale;
Stage #2: With (S)-Mandelic acid In acetone at 35 - 40℃; for 2h; Large scale;
Stage #3: With sodium hydrogencarbonate In dichloromethane; water for 0.5h; Large scale;
78%
omeprazole
73590-58-6

omeprazole

esomeprazole
119141-88-7

esomeprazole

Conditions
ConditionsYield
Stage #1: omeprazole With titanium(IV) isopropylate; diethyl (2S,3S)-tartrate; water; triethylamine In acetone at 35 - 40℃; Large scale;
Stage #2: With (S)-Mandelic acid In acetone at 35 - 40℃; for 2h; Large scale;
Stage #3: With sodium hydrogencarbonate In dichloromethane; water for 0.5h; Large scale;
73%
enantiomeric resolution; inclusion complexation with (S)-(-)-2,2'-dihydroxy-1,1'-binaphthyl;
With diethylamine In methanol Purification / work up; Chiral high performance liquid chromatography; Resolution of racemate;
esomeprazole sodium salt

esomeprazole sodium salt

esomeprazole
119141-88-7

esomeprazole

Conditions
ConditionsYield
Stage #1: esomeprazole sodium salt With titanium(IV) isopropylate; diethyl (2S,3S)-tartrate In water; acetone at 37 - 42℃;
Stage #2: With (S)-Mandelic acid; sodium methylate; triethylamine In water; acetone
Stage #3: With sodium hydroxide In water for 1h;
70.8%
With acetic acid In water at 20℃; pH=~ 9 - 10;
(S)-5-methoxy-2-[[(3,5-dimethyl-4-nitro-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole

(S)-5-methoxy-2-[[(3,5-dimethyl-4-nitro-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole

sodium methylate
124-41-4

sodium methylate

esomeprazole
119141-88-7

esomeprazole

Conditions
ConditionsYield
In methanol at 10 - 50℃; for 3h;
omeprazole
73590-58-6

omeprazole

A

(R)-omeprazole
119141-89-8

(R)-omeprazole

B

esomeprazole
119141-88-7

esomeprazole

Conditions
ConditionsYield
With triethylamine In methanol Purification / work up; Chiral supercritical fluid chromatography; Resolution of racemate;
With N,N-dimethyl-ethanamine In ethanol Purification / work up; Chiral supercritical fluid chromatography; Resolution of racemate;
With N,N-dimethyl-ethanamine In methanol Purification / work up; Chiral supercritical fluid chromatography; Resolution of racemate;
1-(S)-camphor sulfonyl-5-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(S)-sulfinyl]-1H-benzimidazole

1-(S)-camphor sulfonyl-5-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(S)-sulfinyl]-1H-benzimidazole

esomeprazole
119141-88-7

esomeprazole

Conditions
ConditionsYield
Stage #1: 1-(S)-camphor sulfonyl-5-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(S)-sulfinyl]-1H-benzimidazole With methanol; sodium hydroxide; water at 25℃; for 3.16667h;
Stage #2: With acetic acid In methanol; water pH=6.8;
1-(S)-camphor sulfonyl-6-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(S)-sulfinyl]-1H-benzimidazole

1-(S)-camphor sulfonyl-6-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(S)-sulfinyl]-1H-benzimidazole

1-(S)-camphor sulfonyl-5-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(S)-sulfinyl]-1H-benzimidazole

1-(S)-camphor sulfonyl-5-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(S)-sulfinyl]-1H-benzimidazole

esomeprazole
119141-88-7

esomeprazole

Conditions
ConditionsYield
Stage #1: 1-(S)-camphor sulfonyl-6-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(S)-sulfinyl]-1H-benzimidazole; 1-(S)-camphor sulfonyl-5-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(S)-sulfinyl]-1H-benzimidazole With methanol at 25℃; for 0.5h;
Stage #2: With methanol; sodium hydroxide; water at 25℃; for 3.16667h;
Stage #3: With water; acetic acid In methanol pH=6.8;
(S)-5-methoxy-2-(4-methoxy-3,5-dimethylpyridin-2-ylmethane-sulfinyl)-1H-benzimidazole mandalate salt

(S)-5-methoxy-2-(4-methoxy-3,5-dimethylpyridin-2-ylmethane-sulfinyl)-1H-benzimidazole mandalate salt

esomeprazole
119141-88-7

esomeprazole

Conditions
ConditionsYield
With sodium hydrogencarbonate In dichloromethane; water for 0.25 - 0.5h;
esomeprazole magnesium salt

esomeprazole magnesium salt

esomeprazole
119141-88-7

esomeprazole

Conditions
ConditionsYield
Stage #1: esomeprazole magnesium salt With acetic acid In methanol; water at 15 - 20℃; pH=8.0;
Stage #2: With sodium hydroxide In water pH=12.0;
Stage #3: With acetic acid In methanol; water at 15 - 20℃; Product distribution / selectivity;
n/a
With acetic acid In water at 20℃; pH=~ 9 - 10;
esomeprazole potassium

esomeprazole potassium

esomeprazole
119141-88-7

esomeprazole

Conditions
ConditionsYield
With acetic acid In tetrahydrofuran; water at 0 - 30℃; for 2h; pH=7.5 - 8; Product distribution / selectivity;
With acetic acid; diethylamine In water
With acetic acid; methylamine In ethanol; water at 10 - 30℃;
omeprazole sulfide
73590-85-9

omeprazole sulfide

A

(R)-omeprazole
119141-89-8

(R)-omeprazole

B

esomeprazole
119141-88-7

esomeprazole

Conditions
ConditionsYield
With 1,2:4,5-di-O-cyclohexylidene-D-fructopyranose; Cumene hydroperoxide; vanadium(V) oxytripropoxide; N-ethyl-N,N-diisopropylamine In water; ethyl acetate at 20 - 55℃; for 20.1667 - 20.25h; Product distribution / selectivity;
With Oxone; ethylenediaminetetraacetic acid; sodium hydrogencarbonate; 1,2:4,5-di-O-cyclohexylidene-β-D-erythro-hexo-2,3-diulopyranose In acetonitrile at -10 - 20℃; for 3.16667 - 3.25h; Product distribution / selectivity;
Stage #1: omeprazole sulfide With diethyl (2S,3S)-tartrate; titanium(IV) isopropylate In water; toluene at 55℃; for 1h;
Stage #2: With Cumene hydroperoxide In water; toluene at 30℃; for 4.5h; Further stages. Title compound not separated from byproducts.;
(-)-menthyl (S)-5-methoxy-2-benzimidazolylsulphinate
1080503-75-8

(-)-menthyl (S)-5-methoxy-2-benzimidazolylsulphinate

2,3,5-trimethyl-4-methoxypyridine
109371-19-9

2,3,5-trimethyl-4-methoxypyridine

esomeprazole
119141-88-7

esomeprazole

Conditions
ConditionsYield
Stage #1: 4-methoxy-2,3,5-trimethylpyridine With tert.-butyl lithium In tetrahydrofuran at -90 - -80℃;
Stage #2: (-)-menthyl (S)-5-methoxy-2-benzimidazolylsulphinate In tetrahydrofuran at -80 - -20℃; Product distribution / selectivity;
(S)-omeprazole N-benzylcinchoninium salt

(S)-omeprazole N-benzylcinchoninium salt

esomeprazole
119141-88-7

esomeprazole

Conditions
ConditionsYield
With Dowex 50W, H(1+) form In ethanol at 0℃; for 0.5h; pH=4; Product distribution / selectivity;n/a
(S)-omeprazole N-methylcinchonidinium salt

(S)-omeprazole N-methylcinchonidinium salt

esomeprazole
119141-88-7

esomeprazole

Conditions
ConditionsYield
Stage #1: (S)-omeprazole N-methylcinchonidinium salt With hydrogenchloride In water; toluene at 5 - 10℃; for 1h; pH=3;
Stage #2: With sodium hydroxide In water; toluene
Stage #3: With acetic acid In toluene at 5℃; for 0.5h; Product distribution / selectivity;
n/a
With Dowex 50W, H(1+) form In ethanol at 0℃; for 0.5h; pH=4; Product distribution / selectivity;
5-methoxy-2-[(S)-(4-methoxy-3,5-dimethyl-2-pyridinylmethyl)sulphinyl]-1H-benzimidazole barium salt

5-methoxy-2-[(S)-(4-methoxy-3,5-dimethyl-2-pyridinylmethyl)sulphinyl]-1H-benzimidazole barium salt

esomeprazole
119141-88-7

esomeprazole

Conditions
ConditionsYield
With water; acetic acid In dichloromethane at 15℃; for 0.25h; pH=6.5 - 7.0; Product distribution / selectivity;
(S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-7H-benzimidazole strontium salt

(S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-7H-benzimidazole strontium salt

esomeprazole
119141-88-7

esomeprazole

Conditions
ConditionsYield
With water; acetic acid In dichloromethane at 15℃; for 0.25h; pH=6.5 - 7.0; Product distribution / selectivity;
omeprazole sulfide
73590-85-9

omeprazole sulfide

A

(R)-omeprazole
119141-89-8

(R)-omeprazole

B

omeprazole sulphone

omeprazole sulphone

C

esomeprazole
119141-88-7

esomeprazole

Conditions
ConditionsYield
Stage #1: omeprazole sulfide With titanium(IV) isopropylate; diethyl (2S,3S)-tartrate In water at 20 - 70℃; for 1.5h; Heating / reflux;
Stage #2: With Cumene hydroperoxide In water at 20℃; Product distribution / selectivity;
Stage #1: omeprazole sulfide With titanium(IV) isopropylate; diethyl (2S,3S)-tartrate In dichloromethane; water at 20 - 70℃; for 1.5h; Heating / reflux;
Stage #2: With Cumene hydroperoxide In dichloromethane; water at 20℃; Product distribution / selectivity;
With dihydrogen peroxide; Mn-complex of (R,R)-1,2-bis(3,5-di-tert-butyl-2-hydroxybenzylamino)cyclohexane In water; acetonitrile at -10℃; for 5h; Product distribution / selectivity;A n/a
B n/a
C n/a
S-omeprazole*(S)-[1.1'-binaphthalen]-2.2'-diol inclusion complex

S-omeprazole*(S)-[1.1'-binaphthalen]-2.2'-diol inclusion complex

(S)-[1,1']-binaphthalenyl-2,2'-diol
18531-99-2

(S)-[1,1']-binaphthalenyl-2,2'-diol

B

esomeprazole
119141-88-7

esomeprazole

Conditions
ConditionsYield
Stage #1: S-omeprazole*(S)-[1.1'-binaphthalen]-2.2'-diol inclusion complex With sodium hydroxide In tert-butyl methyl ether; water at 20 - 30℃;
Stage #2: With acetic acid In dichloromethane; water pH=7 - 8;
A n/a
B n/a
1-(S)-camphor sulfonyl-5-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(R/S)-sulfinyl]-1H-benzimidazole

1-(S)-camphor sulfonyl-5-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(R/S)-sulfinyl]-1H-benzimidazole

A

(R)-omeprazole
119141-89-8

(R)-omeprazole

B

esomeprazole
119141-88-7

esomeprazole

Conditions
ConditionsYield
Stage #1: 1-(S)-camphor sulfonyl-5-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(R/S)-sulfinyl]-1H-benzimidazole With water; sodium hydroxide at 25℃; for 6.5h;
Stage #2: With hydrogenchloride In dichloromethane; water pH=7.0; Product distribution / selectivity;
esomeprazole
119141-88-7

esomeprazole

esomeprazole magnesium salt

esomeprazole magnesium salt

Conditions
ConditionsYield
With magnesium methanolate In methanol at 20℃; for 1h;100%
With hydrogenchloride; ammonium hydroxide; magnesium chloride In water at 0 - 5℃; for 2h; pH=7 - 8.5; pH-value; Reagent/catalyst;86.5%
Stage #1: esomeprazole With magnesium methanolate In methanol at 25 - 30℃; for 2h;
Stage #2: In methanol; tert-butyl methyl ether for 2h; Temperature;
74.7%
esomeprazole
119141-88-7

esomeprazole

esomeprazole sodium salt

esomeprazole sodium salt

Conditions
ConditionsYield
With sodium methylate In methanol at 20℃; for 1h;100%
With sodium hydroxide In methanol at 25℃; for 1h; Solvent;95.2%
With sodium methylate In methanol at 40℃; for 6h;94.82%
L-arginine
74-79-3

L-arginine

esomeprazole
119141-88-7

esomeprazole

esomeprazole L-arginine salt
942472-45-9

esomeprazole L-arginine salt

Conditions
ConditionsYield
In methanol; water100%
esomeprazole
119141-88-7

esomeprazole

esomeprazole potassium

esomeprazole potassium

Conditions
ConditionsYield
With potassium hydroxide In methanol at 10℃; for 12.25h;95%
With potassium hydroxide In methanol; toluene at 10 - 30℃; for 2.5h;84.33%
With potassium hydroxide In methanol at 5 - 25℃; for 14.5h;n/a
With potassium hydroxide In dichloromethane; water for 2h; Product distribution / selectivity;
With potassium hydroxide In methanol; butanone Cooling with ice;
sodium hydroxide
1310-73-2

sodium hydroxide

esomeprazole
119141-88-7

esomeprazole

esomeprazole sodium salt

esomeprazole sodium salt

Conditions
ConditionsYield
In water Product distribution / selectivity;87%
Stage #1: sodium hydroxide; esomeprazole In methanol; water at 30 - 31℃; for 0.666667h;
Stage #2: In acetone for 1h; Product distribution / selectivity;
Stage #1: sodium hydroxide; esomeprazole In methanol; dichloromethane at 26℃; for 1h;
Stage #2: In dichloromethane at 29℃; for 1.5h; Product distribution / selectivity;
Stage #1: sodium hydroxide; esomeprazole In methanol; acetonitrile at 26℃; for 1h;
Stage #2: In dichloromethane at 29℃; for 1.5h; Product distribution / selectivity;
In methanol at 5 - 30℃; for 11.25 - 11.5h; Product distribution / selectivity;
1-Adamantanamine
768-94-5

1-Adamantanamine

esomeprazole
119141-88-7

esomeprazole

(S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzimidazole 1-adamantan ammonium salt

(S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzimidazole 1-adamantan ammonium salt

Conditions
ConditionsYield
In acetonitrile at 20℃; for 2h;83%
tert-butylamine
75-64-9

tert-butylamine

esomeprazole
119141-88-7

esomeprazole

(S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzimidazole tert-butyl ammonium

(S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzimidazole tert-butyl ammonium

Conditions
ConditionsYield
In acetonitrile at 20℃; for 2h;59%
sodium hydroxide
1310-73-2

sodium hydroxide

esomeprazole
119141-88-7

esomeprazole

omeprazole sodium

omeprazole sodium

Conditions
ConditionsYield
Stage #1: sodium hydroxide; esomeprazole In methanol; water for 0.666667h;
Stage #2: In acetone for 0.5h; Product distribution / selectivity;
Stage #1: sodium hydroxide; esomeprazole In methanol; isopropyl alcohol for 1.5h;
Stage #2: In isopropyl alcohol at 10℃; for 1h;
Stage #1: sodium hydroxide; esomeprazole In methanol; toluene for 1.5h;
Stage #2: In toluene at 29℃; for 1.33333h;
Stage #1: sodium hydroxide; esomeprazole In methanol at 29℃; for 3.5h;
Stage #2: In ethyl acetate at 29℃; for 2.25h;
In methanol at 30℃; for 3.5h;
benzyl chloroformate
501-53-1

benzyl chloroformate

esomeprazole
119141-88-7

esomeprazole

A

(S)-6-methoxy-1-benzyloxycarbonyl-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
960010-92-8

(S)-6-methoxy-1-benzyloxycarbonyl-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole

B

(S)-5-methoxy-1-benzyloxycarbonyl-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
960010-91-7

(S)-5-methoxy-1-benzyloxycarbonyl-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole

Conditions
ConditionsYield
With triethylamine In dichloromethane; 4-methyl-2-pentanone at 0 - 10℃; for 1 - 4h;
magnesium ethylate
2414-98-4

magnesium ethylate

esomeprazole
119141-88-7

esomeprazole

Polytetrafluoroethylene

Polytetrafluoroethylene

esomeprazole magnesium salt

esomeprazole magnesium salt

Conditions
ConditionsYield
In methanol; ethanol; water; acetone
2-[(chlorocarbonyl)(methyl)amino]ethyl ethyl carbonate
635751-00-7

2-[(chlorocarbonyl)(methyl)amino]ethyl ethyl carbonate

esomeprazole
119141-88-7

esomeprazole

A

ethyl 2-[[[(S)-6-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl]-1H-benzimidazol-1yl]carbonyl](methyl)amino]ethyl carbonate

ethyl 2-[[[(S)-6-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl]-1H-benzimidazol-1yl]carbonyl](methyl)amino]ethyl carbonate

B

ethyl 2-[[[(S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl]-1H-benzimidazol-1yl]carbonyl](methyl)amino]ethyl carbonate

ethyl 2-[[[(S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl]-1H-benzimidazol-1yl]carbonyl](methyl)amino]ethyl carbonate

Conditions
ConditionsYield
With triethylamine; dmap In tetrahydrofuran at 60℃; for 6h;
With dmap; triethylamine In tetrahydrofuran at 60℃; for 6h;
With triethylamine; dmap In tetrahydrofuran at 60℃; for 6h;
With dmap; triethylamine In tetrahydrofuran at 60℃; for 6h; Overall yield = 0.92 mg;
N-(2-adamantyl)amine
13074-39-0

N-(2-adamantyl)amine

esomeprazole
119141-88-7

esomeprazole

(S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzimidazole 2-adamantan ammonium salt
847951-88-6

(S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzimidazole 2-adamantan ammonium salt

Conditions
ConditionsYield
Stage #1: N-(2-adamantyl)amine; esomeprazole In ethyl acetate
Stage #2: In ethyl acetate; acetonitrile at 20℃;
[(1R)-1-cyclohexylethyl]amine
5913-13-3

[(1R)-1-cyclohexylethyl]amine

esomeprazole
119141-88-7

esomeprazole

(S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzimidazole (R)-1-cyclohexylethyl ammonium salt
847952-14-1

(S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzimidazole (R)-1-cyclohexylethyl ammonium salt

Conditions
ConditionsYield
In acetonitrile for 1.5h; Product distribution / selectivity;
In ethyl acetate for 0.833333h; Product distribution / selectivity;
esomeprazole
119141-88-7

esomeprazole

5-methoxy-2-[(S)-(4-methoxy-3,5-dimethyl-2-pyridinylmethyl)sulphinyl]-1H-benzimidazole barium salt

5-methoxy-2-[(S)-(4-methoxy-3,5-dimethyl-2-pyridinylmethyl)sulphinyl]-1H-benzimidazole barium salt

Conditions
ConditionsYield
With barium dihydroxide In methanol at 25 - 30℃; for 1 - 2h; Purification / work up;
With barium dihydroxide In water; acetone at 25 - 30℃; for 4 - 5h; Purification / work up;
With barium dihydroxide In methanol
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