DayangChem exported this product to many countries and regions at best price in China. If you are looking for the product’s supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product specifica
Cas:119141-88-7
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inquiryProduct technology and quality stability,perennial production,to meet the supply demand. Quality: 1. Order products, before delivery, according to customer needs, we will provide such as COA, or customer specified demand quality indicators. 2.
Items Standard Result Assay 99.9%min 99.9% Hangzhou Dingyan Chem is a leading manufacturer and supplier of che
Cas:119141-88-7
Min.Order:1 Kilogram
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Type:Trading Company
inquiryJinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu
Stable stock and competitive price Appearance:White powder Storage:Room temperature with sealed well Package:1KG 5KG 25KG Application:As Pharm raw material Transportation:By Courier,Sea or air Port:Shanghai
Hebei yanxi chemical co., LTD is a professional research, development and production Cyromazine、lead diacetate trihydrate /Lead acetate trihydrateC、 2-phenylacetamide 、 4-Aminophenyl-1-phenethylpiperidine 、Citric acid monohydrate 、 Citric acid/c
Cas:119141-88-7
Min.Order:1 Kilogram
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inquiryT he company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality service Appearance:white pow
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:119141-88-7
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inquiryName:Esomeprazole CAS NO:119141-88-7 Molecular formula:C17H19N3O3S Molecular weight:345.4161 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability
Cas:119141-88-7
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:119141-88-7
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryEsomeprazole Basic information Product Name: Esomeprazole Synonyms: Esomeprazole(Na、Mg);(5-methoxy-1H-benzimidazol-2-yl)[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]
Cas:119141-88-7
Min.Order:1 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu
Cas:119141-88-7
Min.Order:1 Kilogram
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Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:119141-88-7
Min.Order:10 Gram
FOB Price: $146.0 / 176.0
Type:Trading Company
inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is
Cas:119141-88-7
Min.Order:10 Gram
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Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:119141-88-7
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:119141-88-7
Min.Order:10 Gram
FOB Price: $0.6
Type:Trading Company
inquiryEsomeprazole CAS:119141-88-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediat
Cas:119141-88-7
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:119141-88-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryMinimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,
Cas:119141-88-7
Min.Order:10 Gram
Negotiable
Type:Trading Company
inquiryHebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several
Cas:119141-88-7
Min.Order:25 Gram
FOB Price: $90.0 / 100.0
Type:Trading Company
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:119141-88-7
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Appearance:white crystalline powder Storage:Sealed in dry,Room Temperature Application:(-)-Omeprazole can be used to treat migraine. Esomeprazole is used to treat certain stomach and esophagus problems (such as acid reflux, ulcers). It w
Cas:119141-88-7
Min.Order:25 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:119141-88-7
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality control system,assigning specific persons in charge of each part of production,from raw material purchase to assembly. 2 Professional R&D
Cas:119141-88-7
Min.Order:10 Gram
FOB Price: $5.0 / 10.0
Type:Trading Company
inquiryProduct Name:Esomeprazole Batch No:20201020 Analysis Date:2020-10-20 Retest Date:2022-10-19 HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years
Cas:119141-88-7
Min.Order:25 Kilogram
FOB Price: $340.0 / 350.0
Type:Other
inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:119141-88-7
Min.Order:1 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:119141-88-7
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryomeprazole sulfide
esomeprazole
Conditions | Yield |
---|---|
Stage #1: omeprazole sulfide With titanium(IV) isopropylate; diethyl (2S,3S)-tartrate In water; toluene at 65 - 70℃; for 0.833333h; Stage #2: With Cumene hydroperoxide; N-ethyl-N,N-diisopropylamine In water; toluene at 2 - 5℃; | 99.2% |
With C23H48NO(1+)*2H(1+)*O40PW12(3-); dihydrogen peroxide; sodium hydrogencarbonate; (1S,2S)-cyclohexane-1,2-diammonium 2,3-dihydroxysuccinate In water; acetone at 28℃; for 15h; Temperature; | 95.6% |
With dihydrogen peroxide In water at 25℃; for 3h; Solvent; | 95% |
esomeprazole
Conditions | Yield |
---|---|
With sodium hydroxide In water; toluene pH=11.5 - 12.0; Product distribution / selectivity; | 99% |
With sodium hydroxide In tert-butyl methyl ether; water pH=11.3; Product distribution / selectivity; | 99% |
With sodium hydroxide; water In toluene pH=11.5 - 12; Product distribution / selectivity; | 99% |
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol; water at 0℃; for 1h; pH=3 - 3.5; Product distribution / selectivity; | A 99% B n/a |
esomeprazole
Conditions | Yield |
---|---|
Stage #1: (S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole [(S)-1,1,2-triphenyl-1,2-ethanediol]2 With sodium hydroxide In water; toluene at 80℃; Stage #2: With acetic acid In water; toluene at 0℃; for 2h; Product distribution / selectivity; | 98% |
Stage #1: (S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole [(S)-1,1,2-triphenyl-1,2-ethanediol]2 With potassium hydroxide In water; toluene at 80℃; Stage #2: With acetic acid In water; toluene at 0℃; for 2h; Product distribution / selectivity; | 95% |
Stage #1: (S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole [(S)-1,1,2-triphenyl-1,2-ethanediol]2 With sodium hydroxide In dichloromethane; water Heating / reflux; Stage #2: With acetic acid In dichloromethane; water at 0℃; for 1h; Product distribution / selectivity; | 84% |
Conditions | Yield |
---|---|
Stage #1: (S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole [(S)-1,1,2-triphenyl-1,2-ethanediol]2 With sodium hydroxide In dichloromethane; water Heating / reflux; Stage #2: With ammonium acetate In dichloromethane; water at 0℃; for 2h; Product distribution / selectivity; | A n/a B 96% |
esomeprazole
Conditions | Yield |
---|---|
In tetrahydrofuran at -5 - 5℃; for 3h; Temperature; | 92.3% |
In tetrahydrofuran at -5 - 0℃; for 3h; Temperature; | 733.2 g |
(chloromethyl)-4-methoxy-3,5-dimethylpyridine
esomeprazole
Conditions | Yield |
---|---|
Stage #1: (chloromethyl)-4-methoxy-3,5-dimethylpyridine With iodine; magnesium In tetrahydrofuran at 30℃; for 5h; Inert atmosphere; Stage #2: (S)-5-methoxy-1H-benzimidazole-2-sulfinic acid-(S)-1-phenyl-ethylester In tetrahydrofuran at -5 - 0℃; for 3h; stereoselective reaction; | 92.3% |
esomeprazole
Conditions | Yield |
---|---|
In tetrahydrofuran at -5 - 0℃; Reagent/catalyst; Temperature; | 92.3% |
esomeprazole
Conditions | Yield |
---|---|
In tetrahydrofuran at -15 - 0℃; for 1h; stereoselective reaction; | 90.2% |
esomeprazole
Conditions | Yield |
---|---|
Stage #1: omeprazole sodium With titanium(IV) isopropylate; diethyl (2S,3S)-tartrate; water; triethylamine In acetone at 35 - 40℃; Large scale; Stage #2: With (S)-Mandelic acid In acetone at 35 - 40℃; for 2h; Large scale; Stage #3: With sodium hydrogencarbonate In dichloromethane; water for 0.5h; Large scale; | 78% |
omeprazole
esomeprazole
Conditions | Yield |
---|---|
Stage #1: omeprazole With titanium(IV) isopropylate; diethyl (2S,3S)-tartrate; water; triethylamine In acetone at 35 - 40℃; Large scale; Stage #2: With (S)-Mandelic acid In acetone at 35 - 40℃; for 2h; Large scale; Stage #3: With sodium hydrogencarbonate In dichloromethane; water for 0.5h; Large scale; | 73% |
enantiomeric resolution; inclusion complexation with (S)-(-)-2,2'-dihydroxy-1,1'-binaphthyl; | |
With diethylamine In methanol Purification / work up; Chiral high performance liquid chromatography; Resolution of racemate; |
esomeprazole
Conditions | Yield |
---|---|
Stage #1: esomeprazole sodium salt With titanium(IV) isopropylate; diethyl (2S,3S)-tartrate In water; acetone at 37 - 42℃; Stage #2: With (S)-Mandelic acid; sodium methylate; triethylamine In water; acetone Stage #3: With sodium hydroxide In water for 1h; | 70.8% |
With acetic acid In water at 20℃; pH=~ 9 - 10; |
sodium methylate
esomeprazole
Conditions | Yield |
---|---|
In methanol at 10 - 50℃; for 3h; |
Conditions | Yield |
---|---|
With triethylamine In methanol Purification / work up; Chiral supercritical fluid chromatography; Resolution of racemate; | |
With N,N-dimethyl-ethanamine In ethanol Purification / work up; Chiral supercritical fluid chromatography; Resolution of racemate; | |
With N,N-dimethyl-ethanamine In methanol Purification / work up; Chiral supercritical fluid chromatography; Resolution of racemate; |
esomeprazole
Conditions | Yield |
---|---|
Stage #1: 1-(S)-camphor sulfonyl-5-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(S)-sulfinyl]-1H-benzimidazole With methanol; sodium hydroxide; water at 25℃; for 3.16667h; Stage #2: With acetic acid In methanol; water pH=6.8; |
Conditions | Yield |
---|---|
Stage #1: 1-(S)-camphor sulfonyl-6-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(S)-sulfinyl]-1H-benzimidazole; 1-(S)-camphor sulfonyl-5-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(S)-sulfinyl]-1H-benzimidazole With methanol at 25℃; for 0.5h; Stage #2: With methanol; sodium hydroxide; water at 25℃; for 3.16667h; Stage #3: With water; acetic acid In methanol pH=6.8; |
esomeprazole
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In dichloromethane; water for 0.25 - 0.5h; |
esomeprazole
Conditions | Yield |
---|---|
Stage #1: esomeprazole magnesium salt With acetic acid In methanol; water at 15 - 20℃; pH=8.0; Stage #2: With sodium hydroxide In water pH=12.0; Stage #3: With acetic acid In methanol; water at 15 - 20℃; Product distribution / selectivity; | n/a |
With acetic acid In water at 20℃; pH=~ 9 - 10; |
esomeprazole
Conditions | Yield |
---|---|
With acetic acid In tetrahydrofuran; water at 0 - 30℃; for 2h; pH=7.5 - 8; Product distribution / selectivity; | |
With acetic acid; diethylamine In water | |
With acetic acid; methylamine In ethanol; water at 10 - 30℃; |
Conditions | Yield |
---|---|
With 1,2:4,5-di-O-cyclohexylidene-D-fructopyranose; Cumene hydroperoxide; vanadium(V) oxytripropoxide; N-ethyl-N,N-diisopropylamine In water; ethyl acetate at 20 - 55℃; for 20.1667 - 20.25h; Product distribution / selectivity; | |
With Oxone; ethylenediaminetetraacetic acid; sodium hydrogencarbonate; 1,2:4,5-di-O-cyclohexylidene-β-D-erythro-hexo-2,3-diulopyranose In acetonitrile at -10 - 20℃; for 3.16667 - 3.25h; Product distribution / selectivity; | |
Stage #1: omeprazole sulfide With diethyl (2S,3S)-tartrate; titanium(IV) isopropylate In water; toluene at 55℃; for 1h; Stage #2: With Cumene hydroperoxide In water; toluene at 30℃; for 4.5h; Further stages. Title compound not separated from byproducts.; |
(-)-menthyl (S)-5-methoxy-2-benzimidazolylsulphinate
2,3,5-trimethyl-4-methoxypyridine
esomeprazole
Conditions | Yield |
---|---|
Stage #1: 4-methoxy-2,3,5-trimethylpyridine With tert.-butyl lithium In tetrahydrofuran at -90 - -80℃; Stage #2: (-)-menthyl (S)-5-methoxy-2-benzimidazolylsulphinate In tetrahydrofuran at -80 - -20℃; Product distribution / selectivity; |
esomeprazole
Conditions | Yield |
---|---|
With Dowex 50W, H(1+) form In ethanol at 0℃; for 0.5h; pH=4; Product distribution / selectivity; | n/a |
esomeprazole
Conditions | Yield |
---|---|
Stage #1: (S)-omeprazole N-methylcinchonidinium salt With hydrogenchloride In water; toluene at 5 - 10℃; for 1h; pH=3; Stage #2: With sodium hydroxide In water; toluene Stage #3: With acetic acid In toluene at 5℃; for 0.5h; Product distribution / selectivity; | n/a |
With Dowex 50W, H(1+) form In ethanol at 0℃; for 0.5h; pH=4; Product distribution / selectivity; |
esomeprazole
Conditions | Yield |
---|---|
With water; acetic acid In dichloromethane at 15℃; for 0.25h; pH=6.5 - 7.0; Product distribution / selectivity; |
esomeprazole
Conditions | Yield |
---|---|
With water; acetic acid In dichloromethane at 15℃; for 0.25h; pH=6.5 - 7.0; Product distribution / selectivity; |
Conditions | Yield |
---|---|
Stage #1: omeprazole sulfide With titanium(IV) isopropylate; diethyl (2S,3S)-tartrate In water at 20 - 70℃; for 1.5h; Heating / reflux; Stage #2: With Cumene hydroperoxide In water at 20℃; Product distribution / selectivity; | |
Stage #1: omeprazole sulfide With titanium(IV) isopropylate; diethyl (2S,3S)-tartrate In dichloromethane; water at 20 - 70℃; for 1.5h; Heating / reflux; Stage #2: With Cumene hydroperoxide In dichloromethane; water at 20℃; Product distribution / selectivity; | |
With dihydrogen peroxide; Mn-complex of (R,R)-1,2-bis(3,5-di-tert-butyl-2-hydroxybenzylamino)cyclohexane In water; acetonitrile at -10℃; for 5h; Product distribution / selectivity; | A n/a B n/a C n/a |
(S)-[1,1']-binaphthalenyl-2,2'-diol
B
esomeprazole
Conditions | Yield |
---|---|
Stage #1: S-omeprazole*(S)-[1.1'-binaphthalen]-2.2'-diol inclusion complex With sodium hydroxide In tert-butyl methyl ether; water at 20 - 30℃; Stage #2: With acetic acid In dichloromethane; water pH=7 - 8; | A n/a B n/a |
Conditions | Yield |
---|---|
Stage #1: 1-(S)-camphor sulfonyl-5-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(R/S)-sulfinyl]-1H-benzimidazole With water; sodium hydroxide at 25℃; for 6.5h; Stage #2: With hydrogenchloride In dichloromethane; water pH=7.0; Product distribution / selectivity; |
esomeprazole
Conditions | Yield |
---|---|
With magnesium methanolate In methanol at 20℃; for 1h; | 100% |
With hydrogenchloride; ammonium hydroxide; magnesium chloride In water at 0 - 5℃; for 2h; pH=7 - 8.5; pH-value; Reagent/catalyst; | 86.5% |
Stage #1: esomeprazole With magnesium methanolate In methanol at 25 - 30℃; for 2h; Stage #2: In methanol; tert-butyl methyl ether for 2h; Temperature; | 74.7% |
esomeprazole
Conditions | Yield |
---|---|
With sodium methylate In methanol at 20℃; for 1h; | 100% |
With sodium hydroxide In methanol at 25℃; for 1h; Solvent; | 95.2% |
With sodium methylate In methanol at 40℃; for 6h; | 94.82% |
Conditions | Yield |
---|---|
In methanol; water | 100% |
esomeprazole
Conditions | Yield |
---|---|
With potassium hydroxide In methanol at 10℃; for 12.25h; | 95% |
With potassium hydroxide In methanol; toluene at 10 - 30℃; for 2.5h; | 84.33% |
With potassium hydroxide In methanol at 5 - 25℃; for 14.5h; | n/a |
With potassium hydroxide In dichloromethane; water for 2h; Product distribution / selectivity; | |
With potassium hydroxide In methanol; butanone Cooling with ice; |
Conditions | Yield |
---|---|
In water Product distribution / selectivity; | 87% |
Stage #1: sodium hydroxide; esomeprazole In methanol; water at 30 - 31℃; for 0.666667h; Stage #2: In acetone for 1h; Product distribution / selectivity; | |
Stage #1: sodium hydroxide; esomeprazole In methanol; dichloromethane at 26℃; for 1h; Stage #2: In dichloromethane at 29℃; for 1.5h; Product distribution / selectivity; | |
Stage #1: sodium hydroxide; esomeprazole In methanol; acetonitrile at 26℃; for 1h; Stage #2: In dichloromethane at 29℃; for 1.5h; Product distribution / selectivity; | |
In methanol at 5 - 30℃; for 11.25 - 11.5h; Product distribution / selectivity; |
1-Adamantanamine
esomeprazole
Conditions | Yield |
---|---|
In acetonitrile at 20℃; for 2h; | 83% |
tert-butylamine
esomeprazole
Conditions | Yield |
---|---|
In acetonitrile at 20℃; for 2h; | 59% |
Conditions | Yield |
---|---|
Stage #1: sodium hydroxide; esomeprazole In methanol; water for 0.666667h; Stage #2: In acetone for 0.5h; Product distribution / selectivity; | |
Stage #1: sodium hydroxide; esomeprazole In methanol; isopropyl alcohol for 1.5h; Stage #2: In isopropyl alcohol at 10℃; for 1h; | |
Stage #1: sodium hydroxide; esomeprazole In methanol; toluene for 1.5h; Stage #2: In toluene at 29℃; for 1.33333h; | |
Stage #1: sodium hydroxide; esomeprazole In methanol at 29℃; for 3.5h; Stage #2: In ethyl acetate at 29℃; for 2.25h; | |
In methanol at 30℃; for 3.5h; |
benzyl chloroformate
esomeprazole
A
(S)-6-methoxy-1-benzyloxycarbonyl-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
B
(S)-5-methoxy-1-benzyloxycarbonyl-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
Conditions | Yield |
---|---|
With triethylamine In dichloromethane; 4-methyl-2-pentanone at 0 - 10℃; for 1 - 4h; |
magnesium ethylate
esomeprazole
Conditions | Yield |
---|---|
In methanol; ethanol; water; acetone |
Conditions | Yield |
---|---|
With triethylamine; dmap In tetrahydrofuran at 60℃; for 6h; | |
With dmap; triethylamine In tetrahydrofuran at 60℃; for 6h; | |
With triethylamine; dmap In tetrahydrofuran at 60℃; for 6h; | |
With dmap; triethylamine In tetrahydrofuran at 60℃; for 6h; Overall yield = 0.92 mg; |
N-(2-adamantyl)amine
esomeprazole
(S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzimidazole 2-adamantan ammonium salt
Conditions | Yield |
---|---|
Stage #1: N-(2-adamantyl)amine; esomeprazole In ethyl acetate Stage #2: In ethyl acetate; acetonitrile at 20℃; |
[(1R)-1-cyclohexylethyl]amine
esomeprazole
(S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzimidazole (R)-1-cyclohexylethyl ammonium salt
Conditions | Yield |
---|---|
In acetonitrile for 1.5h; Product distribution / selectivity; | |
In ethyl acetate for 0.833333h; Product distribution / selectivity; |
esomeprazole
Conditions | Yield |
---|---|
With barium dihydroxide In methanol at 25 - 30℃; for 1 - 2h; Purification / work up; | |
With barium dihydroxide In water; acetone at 25 - 30℃; for 4 - 5h; Purification / work up; | |
With barium dihydroxide In methanol |
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