Products

Refine

Country

Business Type

Certificate

Display

Hebei yanxi chemical co.,LTD.

Hebei yanxi chemical co., LTD is a professional research, development and production Cyromazine、lead diacetate trihydrate /Lead acetate trihydrateC、 2-phenylacetamide 、 4-Aminophenyl-1-phenethylpiperidine 、Citric acid monohydrate 、 Citric acid/c

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

Avibactam manufacturer/supplier

Cas:1192500-31-4

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

Avibactam

Cas:1192500-31-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem’s R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. Near 20 years DayangChem has provided dif

Avibactam

Cas:1192500-31-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Avibactam

Cas:1192500-31-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

high quality AvibactaM

Cas:1192500-31-4

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 1192500-31-4 with competitive price

Cas:1192500-31-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

Sulfuric acid, mono[(1R,2S,5R)-2-(aminocarbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl] ester

Cas:1192500-31-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

AvibactaM CAS:1192500-31-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

AvibactaM CAS:1192500-31-4

Cas:1192500-31-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Sulfuric acid, mono[(1R,2S,5R)-2-(aminocarbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl] ester

Cas:1192500-31-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Sulfuric acid, mono[(1R,2S,5R)-2-(aminocarbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl] ester

Cas:1192500-31-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

Avibactam/High quality/Best price

Cas:1192500-31-4

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

high quality AvibactaM

Cas:1192500-31-4

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: Avibactam CAS No.:1192500-31-4 Molecule Formula:C7H11N3O6S Molecule Weight:265.24 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS SPE

Best Quality Avibactam with good supplier

Cas:1192500-31-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

AvibactaM

Cas:1192500-31-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED

AvibactamCAS NO.: 1192500-31-4

Cas:1192500-31-4

Min.Order:1 Gram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Avibactam

Cas:1192500-31-4

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

1192500-31-4 Sulfuric acid, mono[(1R,2S,5R)-2-(aminocarbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl] ester

Cas:1192500-31-4

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu

Avibactam

Cas:1192500-31-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

AvibactaM

Cas:1192500-31-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD

We are the manufacturer of this product in China. Our price is the lowest in China. CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD., founded in 1984, engages in pharmaceutical research, development, production, process design and technical c

purchase 1192500-31-4 in china exporter

Cas:1192500-31-4

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

1192500-31-4 Sulfuric acid, mono[(1R,2S,5R)-2-(aminocarbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl] ester

Cas:1192500-31-4

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in

SAGECHEM/ Avibactam /Manufacturer in China

Cas:1192500-31-4

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Chemvon Biotechnology Co. Ltd.

Chemvon Biotechnology is one of the leading high-technology manufacturer in the field of pharmaceutical and fine chemical industry. From origins as a research group in technology service, chemvon has progressed into an integrated company with a k

Sulfuric acid mono[(1R,2S,5R)-2-(aminocarbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl] ester

Cas:1192500-31-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

1192500-31-4 Sulfuric acid, mono[(1R,2S,5R)-2-(aminocarbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl] ester

Cas:1192500-31-4

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Senova Technology Company Limited

1.High quality 2.High purity 3.Best price 4.Best service 5.Professional manufacturer 6.Loyal and honest supplier 7.Fast response to customer within 6 hours Application:Pharmaceutical Intermediate

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

AvibactaM

Cas:1192500-31-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white crystalline powder Storage:Sealed in a cool ,dry and microtherm place , avoid light . Package:100g/bottle,1kg/bottle,25kg/drum or as per your request Application:It is an impo

1192500-31-4 supplier in China

Cas:1192500-31-4

Min.Order:100 Gram

Negotiable

Type:Trading Company

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

AvibactaM

Cas:1192500-31-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

BOC Sciences

BOC Sciences is committed to supplying cost-effective products and services. We provide Avibactam. Avibactam is a novel investigational non-beta-lactam beta-lactamase inhibitor that is being developed for possible use in combination with ceftarolin

Avibactam

Cas:1192500-31-4

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Synthetic route

(2S,5R)-6-hydroxy-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide

(2S,5R)-6-hydroxy-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate
1192500-31-4

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate

Conditions
ConditionsYield
With chlorosulfonic acid In N,N-dimethyl-formamide at 30℃; for 48h; Reagent/catalyst;97%
benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate
1192500-31-4

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: potassium tert-butylate / dimethyl sulfoxide; tetrahydrofuran / 20 °C
1.2: -12 °C
2.1: ethyl acetate / Reflux
3.1: methanesulfonic acid / ethyl acetate / 42 °C
3.2: 52 °C
4.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C
4.3: 40 - 45 °C
5.1: ammonia / methanol
6.1: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C
7.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr
View Scheme
Multi-step reaction with 8 steps
1.1: potassium tert-butylate / dimethyl sulfoxide; tetrahydrofuran / 20 °C
1.2: -12 °C
2.1: ethyl acetate / Reflux
3.1: methanesulfonic acid / ethyl acetate / 42 °C
3.2: 52 °C
4.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C
4.3: 40 - 45 °C
5.1: 1 h / 0 °C
5.2: 35 °C
6.1: ammonia / methanol / 20 °C
7.1: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C
8.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr
View Scheme
(1R,2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide
1192651-49-2

(1R,2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate
1192500-31-4

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate

Conditions
ConditionsYield
Stage #1: (1R,2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide With hydrogen; 5% Pd-C In dichloromethane; N,N-dimethyl-formamide under 2250.23 Torr;
Stage #2: With sulfur trioxide-N,N-dimethylformamide complex; acetic acid In dichloromethane; N,N-dimethyl-formamide
With palladium 10% on activated carbon; hydrogen; sulfur trioxide trimethylamine complex; triethylamine In water; isopropyl alcohol for 5h; Large scale; Industrial scale;
With palladium 10% on activated carbon; water; hydrogen; sulfur trioxide trimethylamine complex; triethylamine In isopropyl alcohol
(S)-ethyl N-tert-butoxycarbonylpyroglutamate
144978-35-8, 144978-12-1

(S)-ethyl N-tert-butoxycarbonylpyroglutamate

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate
1192500-31-4

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: potassium tert-butylate / dimethyl sulfoxide; tetrahydrofuran / 20 °C
1.2: -12 °C
2.1: ethyl acetate / Reflux
3.1: methanesulfonic acid / ethyl acetate / 42 °C
3.2: 52 °C
4.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C
4.3: 40 - 45 °C
5.1: ammonia / methanol / 20 °C
6.1: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C
7.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr
View Scheme
benzyl (2S)-2-((tert-butoxycarbonyl)amino)-6-(dimethyl(oxo)-λ6-sulfanylidene)-5-oxohexanoate

benzyl (2S)-2-((tert-butoxycarbonyl)amino)-6-(dimethyl(oxo)-λ6-sulfanylidene)-5-oxohexanoate

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate
1192500-31-4

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: ethyl acetate / Reflux
2.1: methanesulfonic acid / ethyl acetate / 42 °C
2.2: 52 °C
3.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C
3.3: 40 - 45 °C
4.1: potassium hydrogencarbonate / water; 2-methyltetrahydrofuran
4.2: 0 °C
5.1: water; lithium hydroxide monohydrate / acetone / -12 °C
5.2: 0 °C
5.3: -20 - 0 °C
6.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr
View Scheme
Multi-step reaction with 6 steps
1.1: ethyl acetate / Reflux
2.1: methanesulfonic acid / ethyl acetate / 42 °C
2.2: 52 °C
3.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C
3.3: 40 - 45 °C
4.1: ammonia / methanol
5.1: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C
6.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr
View Scheme
Multi-step reaction with 7 steps
1.1: ethyl acetate / Reflux
2.1: methanesulfonic acid / ethyl acetate / 42 °C
2.2: 52 °C
3.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C
3.3: 40 - 45 °C
4.1: 1 h / 0 °C
4.2: 35 °C
5.1: 3-Methylpyridine / dichloromethane / 0 °C
6.1: ammonium carbamate / Novozyme 435 / dichloromethane; acetonitrile / 40 °C / Enzymatic reaction
7.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr
View Scheme
Multi-step reaction with 7 steps
1.1: ethyl acetate / Reflux
2.1: methanesulfonic acid / ethyl acetate / 42 °C
2.2: 52 °C
3.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C
3.3: 40 - 45 °C
4.1: 1 h / 0 °C
4.2: 35 °C
5.1: ammonia / methanol / 20 °C
6.1: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C
7.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr
View Scheme
(2S)-5-(benzyloxyimino)-piperidine-2-carboxylic acid benzyl ester
1133931-74-4

(2S)-5-(benzyloxyimino)-piperidine-2-carboxylic acid benzyl ester

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate
1192500-31-4

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C
1.3: 40 - 45 °C
2.1: potassium hydrogencarbonate / water; 2-methyltetrahydrofuran
2.2: 0 °C
3.1: water; lithium hydroxide monohydrate / acetone / -12 °C
3.2: 0 °C
3.3: -20 - 0 °C
4.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr
View Scheme
Multi-step reaction with 4 steps
1.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C
1.3: 40 - 45 °C
2.1: ammonia / methanol
3.1: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C
4.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr
View Scheme
Multi-step reaction with 5 steps
1.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C
1.3: 40 - 45 °C
2.1: 1 h / 0 °C
2.2: 35 °C
3.1: 3-Methylpyridine / dichloromethane / 0 °C
4.1: ammonium carbamate / Novozyme 435 / dichloromethane; acetonitrile / 40 °C / Enzymatic reaction
5.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr
View Scheme
Multi-step reaction with 5 steps
1.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C
1.3: 40 - 45 °C
2.1: 1 h / 0 °C
2.2: 35 °C
3.1: ammonia / methanol / 20 °C
4.1: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C
5.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr
View Scheme
(2S)-5-benzyloxyaminopiperidin-2-carboxylic acid benzyl ester oxalic acid salt

(2S)-5-benzyloxyaminopiperidin-2-carboxylic acid benzyl ester oxalic acid salt

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate
1192500-31-4

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: methanol / 25 °C / Reflux
2.1: potassium hydrogencarbonate / water; 2-methyltetrahydrofuran
2.2: 0 °C
3.1: water; lithium hydroxide monohydrate / acetone / -12 °C
3.2: 0 °C
3.3: -20 - 0 °C
4.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr
View Scheme
Multi-step reaction with 4 steps
1: methanol / 25 °C / Reflux
2: ammonia / methanol
3: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C
4: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr
View Scheme
Multi-step reaction with 5 steps
1.1: methanol / 25 °C / Reflux
2.1: 1 h / 0 °C
2.2: 35 °C
3.1: 3-Methylpyridine / dichloromethane / 0 °C
4.1: ammonium carbamate / Novozyme 435 / dichloromethane; acetonitrile / 40 °C / Enzymatic reaction
5.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr
View Scheme
Multi-step reaction with 5 steps
1.1: methanol / 25 °C / Reflux
2.1: 1 h / 0 °C
2.2: 35 °C
3.1: ammonia / methanol / 20 °C
4.1: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C
5.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr
View Scheme
benzyl (2S)-5-[(benzyloxy)imino]-2-{[(tert-butoxy)carbonyl]amino}-6-chlorohexanoate
1133931-73-3

benzyl (2S)-5-[(benzyloxy)imino]-2-{[(tert-butoxy)carbonyl]amino}-6-chlorohexanoate

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate
1192500-31-4

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: methanesulfonic acid / ethyl acetate / 42 °C
1.2: 52 °C
2.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C
2.3: 40 - 45 °C
3.1: potassium hydrogencarbonate / water; 2-methyltetrahydrofuran
3.2: 0 °C
4.1: water; lithium hydroxide monohydrate / acetone / -12 °C
4.2: 0 °C
4.3: -20 - 0 °C
5.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr
View Scheme
Multi-step reaction with 5 steps
1.1: methanesulfonic acid / ethyl acetate / 42 °C
1.2: 52 °C
2.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C
2.3: 40 - 45 °C
3.1: ammonia / methanol
4.1: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C
5.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr
View Scheme
Multi-step reaction with 6 steps
1.1: methanesulfonic acid / ethyl acetate / 42 °C
1.2: 52 °C
2.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C
2.3: 40 - 45 °C
3.1: 1 h / 0 °C
3.2: 35 °C
4.1: 3-Methylpyridine / dichloromethane / 0 °C
5.1: ammonium carbamate / Novozyme 435 / dichloromethane; acetonitrile / 40 °C / Enzymatic reaction
6.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr
View Scheme
Multi-step reaction with 6 steps
1.1: methanesulfonic acid / ethyl acetate / 42 °C
1.2: 52 °C
2.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C
2.3: 40 - 45 °C
3.1: 1 h / 0 °C
3.2: 35 °C
4.1: ammonia / methanol / 20 °C
5.1: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C
6.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr
View Scheme
(2S,5R)-6-benzyloxy-7-oxo-1,6-diazabicyclo[3.2.1]octan-2-carboxylic acid methyl ester
1383814-58-1

(2S,5R)-6-benzyloxy-7-oxo-1,6-diazabicyclo[3.2.1]octan-2-carboxylic acid methyl ester

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate
1192500-31-4

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ammonium carbamate / Novozyme 435 / acetonitrile / 40 °C / Enzymatic reaction
2: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr
View Scheme
(2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octan-2-carboxylic acid benzyl ester
1192650-82-0

(2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octan-2-carboxylic acid benzyl ester

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate
1192500-31-4

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: water; lithium hydroxide monohydrate / acetone / -12 °C
1.2: 0 °C
1.3: -20 - 0 °C
2.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr
View Scheme
(2S,5R)-5-(benzyloxyamino)-piperidine-2-carboxylic acid amide
1416134-49-0

(2S,5R)-5-(benzyloxyamino)-piperidine-2-carboxylic acid amide

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate
1192500-31-4

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C
2: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr
View Scheme
Multi-step reaction with 2 steps
1.1: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 20 - 30 °C
1.2: 11 h / 15 °C
1.3: 2 h / 15 - 20 °C
2.1: sulfur trioxide trimethylamine complex; palladium 10% on activated carbon; water; hydrogen; triethylamine / isopropyl alcohol
View Scheme
(2S,5R)-5-benzyloxyaminopiperidin-2-carboxylic acid benzyl ester oxalic acid salt
1171080-45-7

(2S,5R)-5-benzyloxyaminopiperidin-2-carboxylic acid benzyl ester oxalic acid salt

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate
1192500-31-4

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium hydrogencarbonate / water; 2-methyltetrahydrofuran
1.2: 0 °C
2.1: water; lithium hydroxide monohydrate / acetone / -12 °C
2.2: 0 °C
2.3: -20 - 0 °C
3.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr
View Scheme
Multi-step reaction with 3 steps
1: ammonia / methanol
2: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C
3: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr
View Scheme
Multi-step reaction with 4 steps
1.1: 1 h / 0 °C
1.2: 35 °C
2.1: 3-Methylpyridine / dichloromethane / 0 °C
3.1: ammonium carbamate / Novozyme 435 / dichloromethane; acetonitrile / 40 °C / Enzymatic reaction
4.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr
View Scheme
Multi-step reaction with 4 steps
1.1: 1 h / 0 °C
1.2: 35 °C
2.1: ammonia / methanol / 20 °C
3.1: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C
4.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr
View Scheme
ethyl (2S,5R)-5-[(benzyloxy)amino]piperidine-2-carboxylate oxalic acid salt
1416134-48-9

ethyl (2S,5R)-5-[(benzyloxy)amino]piperidine-2-carboxylate oxalic acid salt

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate
1192500-31-4

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 3-Methylpyridine / dichloromethane / 0 °C
2: ammonium carbamate / Novozyme 435 / dichloromethane; acetonitrile / 40 °C / Enzymatic reaction
3: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr
View Scheme
Multi-step reaction with 3 steps
1: ammonia / methanol / 20 °C
2: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C
3: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr
View Scheme
methyl (2S,5R)-5-benzyloxyaminopiperidine-2-carboxylate oxalate
1416134-74-1

methyl (2S,5R)-5-benzyloxyaminopiperidine-2-carboxylate oxalate

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate
1192500-31-4

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium hydrogencarbonate / water; 2-methyltetrahydrofuran
1.2: -5 - -3 °C
2.1: ammonium carbamate / Novozyme 435 / acetonitrile / 40 °C / Enzymatic reaction
3.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr
View Scheme
Multi-step reaction with 3 steps
1: ammonia / methanol / 20 °C
2: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C
3: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr
View Scheme
ethyl (S)-2-((tert-butoxycarbonyl)amino)-6-(dimethyl(oxo)-λ6-sulfanylidene)-5-oxohexanoate
1416134-58-1

ethyl (S)-2-((tert-butoxycarbonyl)amino)-6-(dimethyl(oxo)-λ6-sulfanylidene)-5-oxohexanoate

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate
1192500-31-4

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: ethyl acetate / Reflux
2.1: methanesulfonic acid / ethyl acetate / 42 °C
2.2: 52 °C
3.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C
3.3: 40 - 45 °C
4.1: 3-Methylpyridine / dichloromethane / 0 °C
5.1: ammonium carbamate / Novozyme 435 / dichloromethane; acetonitrile / 40 °C / Enzymatic reaction
6.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr
View Scheme
Multi-step reaction with 6 steps
1.1: ethyl acetate / Reflux
2.1: methanesulfonic acid / ethyl acetate / 42 °C
2.2: 52 °C
3.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C
3.3: 40 - 45 °C
4.1: ammonia / methanol / 20 °C
5.1: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C
6.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr
View Scheme
C20H29ClN2O5
1416134-59-2

C20H29ClN2O5

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate
1192500-31-4

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: methanesulfonic acid / ethyl acetate / 42 °C
1.2: 52 °C
2.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C
2.3: 40 - 45 °C
3.1: 3-Methylpyridine / dichloromethane / 0 °C
4.1: ammonium carbamate / Novozyme 435 / dichloromethane; acetonitrile / 40 °C / Enzymatic reaction
5.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr
View Scheme
Multi-step reaction with 5 steps
1.1: methanesulfonic acid / ethyl acetate / 42 °C
1.2: 52 °C
2.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C
2.3: 40 - 45 °C
3.1: ammonia / methanol / 20 °C
4.1: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C
5.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr
View Scheme
5-benzyloxyiminopiperidine-2S-carboxylic acid ethyl ester
1416134-60-5

5-benzyloxyiminopiperidine-2S-carboxylic acid ethyl ester

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate
1192500-31-4

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C
1.3: 40 - 45 °C
2.1: 3-Methylpyridine / dichloromethane / 0 °C
3.1: ammonium carbamate / Novozyme 435 / dichloromethane; acetonitrile / 40 °C / Enzymatic reaction
4.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr
View Scheme
Multi-step reaction with 4 steps
1.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C
1.3: 40 - 45 °C
2.1: ammonia / methanol / 20 °C
3.1: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C
4.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr
View Scheme
(2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octan-2-carboxylic acid ethyl ester
1416134-63-8

(2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octan-2-carboxylic acid ethyl ester

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate
1192500-31-4

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ammonium carbamate / Novozyme 435 / dichloromethane; acetonitrile / 40 °C / Enzymatic reaction
2: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr
View Scheme
C15H17F3N2O3

C15H17F3N2O3

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate
1192500-31-4

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: trifluoromethylsulfonic anhydride; 2,6-dimethylpyridine / 0.5 h / -25 - -20 °C
1.2: 20 h / -5 - 0 °C
2.1: potassium carbonate / methanol / 1 h
2.2: 0.17 h
3.1: pyridine / 4 h / -15 - 20 °C
4.1: palladium 10% on activated carbon; ammonium formate / methanol / 2 h / Reflux
5.1: chlorosulfonic acid / N,N-dimethyl-formamide / 48 h / 30 °C
View Scheme
C22H24F3N3O3

C22H24F3N3O3

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate
1192500-31-4

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: potassium carbonate / methanol / 1 h
1.2: 0.17 h
2.1: pyridine / 4 h / -15 - 20 °C
3.1: palladium 10% on activated carbon; ammonium formate / methanol / 2 h / Reflux
4.1: chlorosulfonic acid / N,N-dimethyl-formamide / 48 h / 30 °C
View Scheme
(2S,5R)-N-benzyl-5-(benzyloxyamino)piperidin-2-carboxamide

(2S,5R)-N-benzyl-5-(benzyloxyamino)piperidin-2-carboxamide

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate
1192500-31-4

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: pyridine / 4 h / -15 - 20 °C
2: palladium 10% on activated carbon; ammonium formate / methanol / 2 h / Reflux
3: chlorosulfonic acid / N,N-dimethyl-formamide / 48 h / 30 °C
View Scheme
(S)-5-oxo-2-piperidinecarboxylic acid
146467-21-2

(S)-5-oxo-2-piperidinecarboxylic acid

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate
1192500-31-4

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: 2,6-dimethylpyridine / dichloromethane / 2 h / Reflux
2.1: D-glucose; citric acid; disodium hydrogenphosphate / ethyl acetate; water / 25 h / 30 °C
3.1: triethylamine / tetrahydrofuran / 0.5 h
3.2: 1 h / -7 - -5 °C
4.1: trifluoromethylsulfonic anhydride; 2,6-dimethylpyridine / 0.5 h / -25 - -20 °C
4.2: 20 h / -5 - 0 °C
5.1: potassium carbonate / methanol / 1 h
5.2: 0.17 h
6.1: pyridine / 4 h / -15 - 20 °C
7.1: palladium 10% on activated carbon; ammonium formate / methanol / 2 h / Reflux
8.1: chlorosulfonic acid / N,N-dimethyl-formamide / 48 h / 30 °C
View Scheme
C13H16N2O2

C13H16N2O2

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate
1192500-31-4

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: D-glucose; citric acid; disodium hydrogenphosphate / ethyl acetate; water / 25 h / 30 °C
2.1: triethylamine / tetrahydrofuran / 0.5 h
2.2: 1 h / -7 - -5 °C
3.1: trifluoromethylsulfonic anhydride; 2,6-dimethylpyridine / 0.5 h / -25 - -20 °C
3.2: 20 h / -5 - 0 °C
4.1: potassium carbonate / methanol / 1 h
4.2: 0.17 h
5.1: pyridine / 4 h / -15 - 20 °C
6.1: palladium 10% on activated carbon; ammonium formate / methanol / 2 h / Reflux
7.1: chlorosulfonic acid / N,N-dimethyl-formamide / 48 h / 30 °C
View Scheme
C13H18N2O2

C13H18N2O2

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate
1192500-31-4

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: triethylamine / tetrahydrofuran / 0.5 h
1.2: 1 h / -7 - -5 °C
2.1: trifluoromethylsulfonic anhydride; 2,6-dimethylpyridine / 0.5 h / -25 - -20 °C
2.2: 20 h / -5 - 0 °C
3.1: potassium carbonate / methanol / 1 h
3.2: 0.17 h
4.1: pyridine / 4 h / -15 - 20 °C
5.1: palladium 10% on activated carbon; ammonium formate / methanol / 2 h / Reflux
6.1: chlorosulfonic acid / N,N-dimethyl-formamide / 48 h / 30 °C
View Scheme
(2S,5S)-1-(tert-butyl) 2-ethyl 5-hydroxylpiperidine-1,2-dicarboxylate

(2S,5S)-1-(tert-butyl) 2-ethyl 5-hydroxylpiperidine-1,2-dicarboxylate

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate
1192500-31-4

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 2,6-dimethylpyridine; trifluoromethylsulfonic anhydride / acetonitrile / -30 °C
1.2: 12.5 h / -30 - 20 °C
2.1: trifluoroacetic acid / dichloromethane / 15 h / 0 - 20 °C
3.1: ammonia; methanol / 8 h / 20 °C
4.1: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 20 - 30 °C
4.2: 11 h / 15 °C
4.3: 2 h / 15 - 20 °C
5.1: sulfur trioxide trimethylamine complex; palladium 10% on activated carbon; water; hydrogen; triethylamine / isopropyl alcohol
View Scheme
(2S,5R)-5-(benzyloxyamino)piperidin-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester

(2S,5R)-5-(benzyloxyamino)piperidin-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate
1192500-31-4

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: trifluoroacetic acid / dichloromethane / 15 h / 0 - 20 °C
2.1: ammonia; methanol / 8 h / 20 °C
3.1: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 20 - 30 °C
3.2: 11 h / 15 °C
3.3: 2 h / 15 - 20 °C
4.1: sulfur trioxide trimethylamine complex; palladium 10% on activated carbon; water; hydrogen; triethylamine / isopropyl alcohol
View Scheme
(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate
1192500-31-4

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate

sodium 2-ethylhexanoic acid

sodium 2-ethylhexanoic acid

(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt
1192491-61-4

(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt

Conditions
ConditionsYield
In 2-methyl-propan-1-ol for 0.833333h; Solvent; Time; Concentration; Reflux;77%
(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate
1192500-31-4

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate

tetra(n-butyl)ammonium hydrogensulfate
32503-27-8

tetra(n-butyl)ammonium hydrogensulfate

({[(2S,5R)-2-carbamoyl-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3,2,1]-oct-6-yl]oxy}sulfonyl)tetrabutylammonium salt
1192651-80-1, 1416134-53-6

({[(2S,5R)-2-carbamoyl-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3,2,1]-oct-6-yl]oxy}sulfonyl)tetrabutylammonium salt

Conditions
ConditionsYield
In water
(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate
1192500-31-4

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate

(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt
1192491-61-4

(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetic acid / water; isopropyl alcohol; dichloromethane / Large scale; Industrial scale
2: sodium 2-ethylhexanoic acid / water; ethanol / 6 h / 30 °C / Large scale; Industrial scale
View Scheme
(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate
1192500-31-4

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate

tetrabutylammonium acetate
10534-59-5

tetrabutylammonium acetate

({[(2S,5R)-2-carbamoyl-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3,2,1]-oct-6-yl]oxy}sulfonyl)tetrabutylammonium salt
1192651-80-1, 1416134-53-6

({[(2S,5R)-2-carbamoyl-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3,2,1]-oct-6-yl]oxy}sulfonyl)tetrabutylammonium salt

Conditions
ConditionsYield
With acetic acid In dichloromethane; water; isopropyl alcohol Large scale; Industrial scale;133 kg
With acetic acid In water814 g

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View