Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu
Cas:1192491-61-4
Min.Order:1 Gram
FOB Price: $1.0
Type:Manufacturers
inquiryWe can provide high quality,cheap price,spot supply and good service. If you have any questions,pls do not hesitate to contact us. Hangzhou Hysen pharma CO.,LTD. is a professional Pharmaceutical company. We are specialized in manufacturing and R&am
Cas:1192491-61-4
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiryRunhui Chem focus on high complex new type intermediates and fine chemical custom synthesis,scale-up production and rare chemicals trade.product category including intermediates&api,catalyst and electronic chemicals.covering 811 square meters
Cas:1192491-61-4
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryLuhan Pharmachem Co., Ltd. owns strong elite professional quality sales force, has the customer base from the US, Europe, Japan, Southeast Asia, Korea, Hong Kong, Taiwan and other countries and regions, the company operates in accordance with the mod
Items Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------
Cas:1192491-61-4
Min.Order:1 Gram
FOB Price: $100.0 / 500.0
Type:Trading Company
inquiryUnique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:cool dry place Package:1kg/foil bag;25kg/drum Application:medicine raw material Transportatio
Cas:1192491-61-4
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryAvibactam sodium CAS No.:1192491-61-4 Name: Avibactam sodium Synonyms: (2S,5R)-7-Oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide monosodium salt; NXL 104 Molecular Structure Molecular Formula: C7H10N3O6S.Na
Cas:1192491-61-4
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Other
inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:1192491-61-4
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi
DayangChem exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product s
Cas:1192491-61-4
Min.Order:1 Kilogram
FOB Price: $5.0
Type:Lab/Research institutions
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:1192491-61-4
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryName:Avibactam Sodium Salt The alias:NXL 104; Sulfuric acid Mono[(1R,2S,5R)-2-(aminocarbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl] ester sodium salt CAS NO:1192491-61-4 Molecular formula:C7H10N3NaO6S Molecular weight:287.22600 Product Quality
Cas:1192491-61-4
Min.Order:25 Kilogram
FOB Price: $1.0 / 2.0
Type:Other
inquiryTIANFUCHEM--1192491-61-4--NXL 104 factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business relationshi
Cas:1192491-61-4
Min.Order:1 Metric Ton
FOB Price: $2000.0
Type:Lab/Research institutions
inquiryWe are a professional chemicals, APIs and plant extract leading manufacturer in China. We are specialized in chemical synthesis, process development of pharmaceutical intermediates, active pharmaceutical ingredients (APIs), plant extract and rare
Cas:1192491-61-4
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:1192491-61-4
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryName: Avibactam Sodium Salt Synonyms: Avibactam Sodium CAS:1192491-61-4 MF: C7H10N3NaO6S Appearance: white powder Storage:Store in cool and dry place, away from sun light. Package: 25kgs/drum Application:APIs Transportation:By sea or by air
1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White crystalline powder Storage:Store in sealed containers
Cas:1192491-61-4
Min.Order:100 Gram
Negotiable
Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:1192491-61-4
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWe own stock of a 15-year factory. Cooperate with 100+ manufacturers. Customer satisfaction is close to 100%. Awarded best supplier for many years! Guarantee all products with top quality. Refund double if our price isn't the best! Contact me
Cas:1192491-61-4
Min.Order:1 Kilogram
FOB Price: $20.0 / 30.0
Type:Trading Company
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:1192491-61-4
Min.Order:1 Gram
FOB Price: $82.0 / 93.5
Type:Trading Company
inquiryNXL 104 CAS: 1192491-61-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,
Cas:1192491-61-4
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Xi'an Yinherb Bio-Tech Co., Ltd was founded in 2009, We have more than 10 experienced doctors and scientists and professional managers, specializing in Nootropics, Sarms and Peptides researching and developing, and become the lead
Cas:1192491-61-4
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryAppearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By
Cas:1192491-61-4
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:1192491-61-4
Min.Order:5 Gram
Negotiable
Type:Lab/Research institutions
inquiryHubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other
Cas:1192491-61-4
Min.Order:1 Kilogram
FOB Price: $3.0 / 5.0
Type:Trading Company
inquiryFactory direct sales, accept customization. Avibactam (NXL104) is a novel β-lactamase inhibitor with a non-lactam structural scaffold. NXL104 irreversibly inhibits lactamase from Mycobacterium tuberculosis. Kind Pharma has its own laboratory,
Cas:1192491-61-4
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Cas:1192491-61-4
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry({[(2S,5R)-2-carbamoyl-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3,2,1]-oct-6-yl]oxy}sulfonyl)tetrabutylammonium salt
(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt
Conditions | Yield |
---|---|
Stage #1: ({[(2S,5R)-2-carbamoyl-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3,2,1]-oct-6-yl]oxy}sulfonyl)tetrabutylammonium salt With tetrafluoroboric acid; 2,2,2-trifluoroethanol Stage #2: With sodium hydrogencarbonate at 0℃; for 1h; | 100% |
With sodium 2-ethylhexanoic acid In ethanol; water at 20℃; for 3h; | 99.6% |
With sodium 2-ethylhexanoic acid In ethanol; water at 20℃; for 3h; | 96.2% |
(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt
Conditions | Yield |
---|---|
With sodium 2-ethylhexanoic acid In ethanol | 89% |
(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt
Conditions | Yield |
---|---|
With sodium 2-ethylhexanoic acid In ethanol | 88% |
(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt
Conditions | Yield |
---|---|
With sodium 2-ethylhexanoic acid In ethanol | 86% |
(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt
Conditions | Yield |
---|---|
With sodium 2-ethylhexanoic acid In ethanol | 86% |
(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt
Conditions | Yield |
---|---|
With sodium 2-ethylhexanoic acid In ethanol | 86% |
(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt
Conditions | Yield |
---|---|
Stage #1: (2S,5R)-6-hydroxy-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide With pyridine; sulfur trioxide pyridine complex at 20℃; for 20h; Stage #2: With sodium dihydrogenphosphate In water | 80% |
Multi-step reaction with 2 steps 1.1: α-picoline; thiocyanate trioxide / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere 2.1: 2,2,2-trifluoroethanol; tetrafluoroboric acid 2.2: 1 h / 0 °C View Scheme | |
Multi-step reaction with 2 steps 1: triethylamine; sulfur trioxide trimethylamine complex / ethanol; water 2: sodium 2-ethylhexanoic acid / ethanol View Scheme | |
Multi-step reaction with 2 steps 1: triethylamine; sulfur trioxide trimethylamine complex / ethanol; water 2: sodium 2-ethylhexanoic acid / ethanol View Scheme | |
Multi-step reaction with 3 steps 1.1: sodium hexamethyldisilazane; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere 1.2: -78 - 20 °C / Inert atmosphere 2.1: palladium 10% on activated carbon; hydrogen / acetonitrile / 1.33 h / 20 °C / Inert atmosphere 3.1: sodium hydrogencarbonate / dimethylsulfoxide-d6; water-d2 View Scheme |
(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt
Conditions | Yield |
---|---|
With sodium 2-ethylhexanoic acid In ethanol; water at 15 - 40℃; for 4h; | 80% |
With sodium 2-ethylhexanoic acid In ethanol | 4.6 g |
With sodium isooctanoate In ethanol; water at 35 - 40℃; for 4h; |
(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt
Conditions | Yield |
---|---|
With sodium 2-ethylhexanoic acid In ethanol | 80% |
(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicylco[3.2.1]octan-6-yl hydrogensulfate
(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt
Conditions | Yield |
---|---|
In 2-methyl-propan-1-ol for 0.833333h; Solvent; Time; Concentration; Reflux; | 77% |
(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt
Conditions | Yield |
---|---|
With sodium 2-ethylhexanoic acid In ethanol | 74% |
(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt
Conditions | Yield |
---|---|
With sodium 2-ethylhexanoic acid In ethanol | 74% |
(1R,2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide
(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: triethylamine; hydrogen; sulfur trioxide trimethylamine complex / palladium-on-charcoal / isopropyl alcohol; water 2: sodium 2-ethylhexanoic acid / ethanol; water View Scheme | |
Multi-step reaction with 3 steps 1.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide 1.2: 20 °C 1.3: pH > 6 2.1: dichloromethane; water 3.1: sodium 2-ethylhexanoic acid / ethanol; water View Scheme | |
Multi-step reaction with 3 steps 1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr 2: water 3: sodium 2-ethylhexanoic acid / ethanol; water View Scheme |
(2S,5R)-5-(benzyloxyamino)-piperidine-2-carboxylic acid amide
(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C 2: triethylamine; hydrogen; sulfur trioxide trimethylamine complex / palladium-on-charcoal / isopropyl alcohol; water 3: sodium 2-ethylhexanoic acid / ethanol; water View Scheme | |
Multi-step reaction with 4 steps 1.1: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C 2.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide 2.2: 20 °C 2.3: pH > 6 3.1: dichloromethane; water 4.1: sodium 2-ethylhexanoic acid / ethanol; water View Scheme | |
Multi-step reaction with 4 steps 1: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C 2: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr 3: water 4: sodium 2-ethylhexanoic acid / ethanol; water View Scheme |
(2S,5R)-5-benzyloxyaminopiperidin-2-carboxylic acid benzyl ester oxalic acid salt
(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: potassium hydrogencarbonate / water; 2-methyltetrahydrofuran 1.2: 0 °C 2.1: water; lithium hydroxide monohydrate / acetone / -12 °C 2.2: 0 °C 2.3: -20 - 0 °C 3.1: triethylamine; hydrogen; sulfur trioxide trimethylamine complex / palladium-on-charcoal / isopropyl alcohol; water 4.1: sodium 2-ethylhexanoic acid / ethanol; water View Scheme | |
Multi-step reaction with 4 steps 1: ammonia / methanol 2: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C 3: triethylamine; hydrogen; sulfur trioxide trimethylamine complex / palladium-on-charcoal / isopropyl alcohol; water 4: sodium 2-ethylhexanoic acid / ethanol; water View Scheme | |
Multi-step reaction with 5 steps 1.1: potassium hydrogencarbonate / water; 2-methyltetrahydrofuran 1.2: 0 °C 2.1: water; lithium hydroxide monohydrate / acetone / -12 °C 2.2: 0 °C 2.3: -20 - 0 °C 3.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr 4.1: water 5.1: sodium 2-ethylhexanoic acid / ethanol; water View Scheme |
ethyl (2S,5R)-5-[(benzyloxy)amino]piperidine-2-carboxylate oxalic acid salt
(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 3-Methylpyridine / dichloromethane / 0 °C 2: ammonium carbamate / Novozyme 435 / dichloromethane; acetonitrile / 40 °C / Enzymatic reaction 3: triethylamine; hydrogen; sulfur trioxide trimethylamine complex / palladium-on-charcoal / isopropyl alcohol; water 4: sodium 2-ethylhexanoic acid / ethanol; water View Scheme | |
Multi-step reaction with 4 steps 1: ammonia / methanol / 20 °C 2: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C 3: triethylamine; hydrogen; sulfur trioxide trimethylamine complex / palladium-on-charcoal / isopropyl alcohol; water 4: sodium 2-ethylhexanoic acid / ethanol; water View Scheme | |
Multi-step reaction with 5 steps 1.1: 3-Methylpyridine / dichloromethane / 0 °C 2.1: ammonium carbamate / Novozyme 435 / dichloromethane; acetonitrile / 40 °C / Enzymatic reaction 3.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide 3.2: 20 °C 3.3: pH > 6 4.1: dichloromethane; water 5.1: sodium 2-ethylhexanoic acid / ethanol; water View Scheme |
benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1.1: potassium tert-butylate / dimethyl sulfoxide; tetrahydrofuran / 20 °C 1.2: -12 °C 2.1: ethyl acetate / Reflux 3.1: methanesulfonic acid / ethyl acetate / 42 °C 3.2: 52 °C 4.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C 4.3: 40 - 45 °C 5.1: 1 h / 0 °C 5.2: 35 °C 6.1: ammonia / methanol / 20 °C 7.1: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C 8.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr 9.1: water 10.1: sodium 2-ethylhexanoic acid / ethanol; water View Scheme | |
Multi-step reaction with 10 steps 1.1: potassium tert-butylate / dimethyl sulfoxide; tetrahydrofuran / 20 °C 1.2: -12 °C 2.1: ethyl acetate / Reflux 3.1: methanesulfonic acid / ethyl acetate / 42 °C 3.2: 52 °C 4.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C 4.3: 40 - 45 °C 5.1: 1 h / 0 °C 5.2: 35 °C 6.1: ammonia / methanol / 20 °C 7.1: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C 8.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide 8.2: 20 °C 8.3: pH > 6 9.1: dichloromethane; water 10.1: sodium 2-ethylhexanoic acid / ethanol; water View Scheme | |
Multi-step reaction with 8 steps 1.1: potassium tert-butylate / dimethyl sulfoxide; tetrahydrofuran / 20 °C 1.2: -12 °C 2.1: ethyl acetate / Reflux 3.1: methanesulfonic acid / ethyl acetate / 42 °C 3.2: 52 °C 4.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C 4.3: 40 - 45 °C 5.1: ammonia / methanol 6.1: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C 7.1: triethylamine; hydrogen; sulfur trioxide trimethylamine complex / palladium-on-charcoal / isopropyl alcohol; water 8.1: sodium 2-ethylhexanoic acid / ethanol; water View Scheme |
(S)-ethyl N-tert-butoxycarbonylpyroglutamate
(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: potassium tert-butylate / dimethyl sulfoxide; tetrahydrofuran / 20 °C 1.2: -12 °C 2.1: ethyl acetate / Reflux 3.1: methanesulfonic acid / ethyl acetate / 42 °C 3.2: 52 °C 4.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C 4.3: 40 - 45 °C 5.1: ammonia / methanol / 20 °C 6.1: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C 7.1: triethylamine; hydrogen; sulfur trioxide trimethylamine complex / palladium-on-charcoal / isopropyl alcohol; water 8.1: sodium 2-ethylhexanoic acid / ethanol; water View Scheme | |
Multi-step reaction with 9 steps 1.1: potassium tert-butylate / dimethyl sulfoxide; tetrahydrofuran / 20 °C 1.2: -12 °C 2.1: ethyl acetate / Reflux 3.1: methanesulfonic acid / ethyl acetate / 42 °C 3.2: 52 °C 4.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C 4.3: 40 - 45 °C 5.1: ammonia / methanol / 20 °C 6.1: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C 7.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr 8.1: water 9.1: sodium 2-ethylhexanoic acid / ethanol; water View Scheme | |
Multi-step reaction with 9 steps 1.1: potassium tert-butylate / dimethyl sulfoxide; tetrahydrofuran / 20 °C 1.2: -12 °C 2.1: ethyl acetate / Reflux 3.1: methanesulfonic acid / ethyl acetate / 42 °C 3.2: 52 °C 4.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C 4.3: 40 - 45 °C 5.1: ammonia / methanol / 20 °C 6.1: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C 7.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide 7.2: 20 °C 7.3: pH > 6 8.1: dichloromethane; water 9.1: sodium 2-ethylhexanoic acid / ethanol; water View Scheme |
(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: ethyl acetate / Reflux 2.1: methanesulfonic acid / ethyl acetate / 42 °C 2.2: 52 °C 3.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C 3.3: 40 - 45 °C 4.1: ammonia / methanol 5.1: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C 6.1: triethylamine; hydrogen; sulfur trioxide trimethylamine complex / palladium-on-charcoal / isopropyl alcohol; water 7.1: sodium 2-ethylhexanoic acid / ethanol; water View Scheme | |
Multi-step reaction with 7 steps 1.1: ethyl acetate / Reflux 2.1: methanesulfonic acid / ethyl acetate / 42 °C 2.2: 52 °C 3.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C 3.3: 40 - 45 °C 4.1: potassium hydrogencarbonate / water; 2-methyltetrahydrofuran 4.2: 0 °C 5.1: water; lithium hydroxide monohydrate / acetone / -12 °C 5.2: 0 °C 5.3: -20 - 0 °C 6.1: triethylamine; hydrogen; sulfur trioxide trimethylamine complex / palladium-on-charcoal / isopropyl alcohol; water 7.1: sodium 2-ethylhexanoic acid / ethanol; water View Scheme | |
Multi-step reaction with 8 steps 1.1: ethyl acetate / Reflux 2.1: methanesulfonic acid / ethyl acetate / 42 °C 2.2: 52 °C 3.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C 3.3: 40 - 45 °C 4.1: 1 h / 0 °C 4.2: 35 °C 5.1: ammonia / methanol / 20 °C 6.1: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C 7.1: triethylamine; hydrogen; sulfur trioxide trimethylamine complex / palladium-on-charcoal / isopropyl alcohol; water 8.1: sodium 2-ethylhexanoic acid / ethanol; water View Scheme |
(2S)-5-(benzyloxyimino)-piperidine-2-carboxylic acid benzyl ester
(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C 1.3: 40 - 45 °C 2.1: ammonia / methanol 3.1: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C 4.1: triethylamine; hydrogen; sulfur trioxide trimethylamine complex / palladium-on-charcoal / isopropyl alcohol; water 5.1: sodium 2-ethylhexanoic acid / ethanol; water View Scheme | |
Multi-step reaction with 5 steps 1.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C 1.3: 40 - 45 °C 2.1: potassium hydrogencarbonate / water; 2-methyltetrahydrofuran 2.2: 0 °C 3.1: water; lithium hydroxide monohydrate / acetone / -12 °C 3.2: 0 °C 3.3: -20 - 0 °C 4.1: triethylamine; hydrogen; sulfur trioxide trimethylamine complex / palladium-on-charcoal / isopropyl alcohol; water 5.1: sodium 2-ethylhexanoic acid / ethanol; water View Scheme | |
Multi-step reaction with 6 steps 1.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C 1.3: 40 - 45 °C 2.1: ammonia / methanol 3.1: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C 4.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr 5.1: water 6.1: sodium 2-ethylhexanoic acid / ethanol; water View Scheme |
(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: methanol / 25 °C / Reflux 2.1: potassium hydrogencarbonate / water; 2-methyltetrahydrofuran 2.2: 0 °C 3.1: water; lithium hydroxide monohydrate / acetone / -12 °C 3.2: 0 °C 3.3: -20 - 0 °C 4.1: triethylamine; hydrogen; sulfur trioxide trimethylamine complex / palladium-on-charcoal / isopropyl alcohol; water 5.1: sodium 2-ethylhexanoic acid / ethanol; water View Scheme | |
Multi-step reaction with 5 steps 1: methanol / 25 °C / Reflux 2: ammonia / methanol 3: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C 4: triethylamine; hydrogen; sulfur trioxide trimethylamine complex / palladium-on-charcoal / isopropyl alcohol; water 5: sodium 2-ethylhexanoic acid / ethanol; water View Scheme | |
Multi-step reaction with 6 steps 1.1: methanol / 25 °C / Reflux 2.1: potassium hydrogencarbonate / water; 2-methyltetrahydrofuran 2.2: 0 °C 3.1: water; lithium hydroxide monohydrate / acetone / -12 °C 3.2: 0 °C 3.3: -20 - 0 °C 4.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr 5.1: water 6.1: sodium 2-ethylhexanoic acid / ethanol; water View Scheme |
benzyl (2S)-5-[(benzyloxy)imino]-2-{[(tert-butoxy)carbonyl]amino}-6-chlorohexanoate
(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: methanesulfonic acid / ethyl acetate / 42 °C 1.2: 52 °C 2.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C 2.3: 40 - 45 °C 3.1: ammonia / methanol 4.1: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C 5.1: triethylamine; hydrogen; sulfur trioxide trimethylamine complex / palladium-on-charcoal / isopropyl alcohol; water 6.1: sodium 2-ethylhexanoic acid / ethanol; water View Scheme | |
Multi-step reaction with 6 steps 1.1: methanesulfonic acid / ethyl acetate / 42 °C 1.2: 52 °C 2.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C 2.3: 40 - 45 °C 3.1: potassium hydrogencarbonate / water; 2-methyltetrahydrofuran 3.2: 0 °C 4.1: water; lithium hydroxide monohydrate / acetone / -12 °C 4.2: 0 °C 4.3: -20 - 0 °C 5.1: triethylamine; hydrogen; sulfur trioxide trimethylamine complex / palladium-on-charcoal / isopropyl alcohol; water 6.1: sodium 2-ethylhexanoic acid / ethanol; water View Scheme | |
Multi-step reaction with 7 steps 1.1: methanesulfonic acid / ethyl acetate / 42 °C 1.2: 52 °C 2.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C 2.3: 40 - 45 °C 3.1: 1 h / 0 °C 3.2: 35 °C 4.1: ammonia / methanol / 20 °C 5.1: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C 6.1: triethylamine; hydrogen; sulfur trioxide trimethylamine complex / palladium-on-charcoal / isopropyl alcohol; water 7.1: sodium 2-ethylhexanoic acid / ethanol; water View Scheme |
(2S,5R)-6-benzyloxy-7-oxo-1,6-diazabicyclo[3.2.1]octan-2-carboxylic acid methyl ester
(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: ammonium carbamate / Novozyme 435 / acetonitrile / 40 °C / Enzymatic reaction 2: triethylamine; hydrogen; sulfur trioxide trimethylamine complex / palladium-on-charcoal / isopropyl alcohol; water 3: sodium 2-ethylhexanoic acid / ethanol; water View Scheme | |
Multi-step reaction with 4 steps 1.1: ammonium carbamate / Novozyme 435 / acetonitrile / 40 °C / Enzymatic reaction 2.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide 2.2: 20 °C 2.3: pH > 6 3.1: dichloromethane; water 4.1: sodium 2-ethylhexanoic acid / ethanol; water View Scheme | |
Multi-step reaction with 4 steps 1: ammonium carbamate / Novozyme 435 / acetonitrile / 40 °C / Enzymatic reaction 2: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr 3: water 4: sodium 2-ethylhexanoic acid / ethanol; water View Scheme | |
Multi-step reaction with 4 steps 1.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 0.25 h / 0 °C 2.1: triethylamine; isobutyl chloroformate / dichloromethane / 0.33 h / 0 °C 2.2: 1 h / 20 °C 3.1: hydrogen; palladium 10% on activated carbon / water; methanol / 0.75 h 4.1: pyridine; sulfur trioxide pyridine complex / 20 h / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 0.25 h / 0 °C 2.1: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / 0.17 h / 0 °C 2.2: 0.5 h 3.1: ammonium hydroxide / dichloromethane / 1 h / 0 - 20 °C 4.1: hydrogen; palladium 10% on activated carbon / water; methanol / 0.75 h 5.1: pyridine; sulfur trioxide pyridine complex / 20 h / 20 °C View Scheme |
(2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octan-2-carboxylic acid benzyl ester
(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: water; lithium hydroxide monohydrate / acetone / -12 °C 1.2: 0 °C 1.3: -20 - 0 °C 2.1: triethylamine; hydrogen; sulfur trioxide trimethylamine complex / palladium-on-charcoal / isopropyl alcohol; water 3.1: sodium 2-ethylhexanoic acid / ethanol; water View Scheme | |
Multi-step reaction with 4 steps 1.1: water; lithium hydroxide monohydrate / acetone / -12 °C 1.2: 0 °C 1.3: -20 - 0 °C 2.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr 3.1: water 4.1: sodium 2-ethylhexanoic acid / ethanol; water View Scheme | |
Multi-step reaction with 4 steps 1.1: water; lithium hydroxide monohydrate / acetone / -12 °C 1.2: 0 °C 1.3: -20 - 0 °C 2.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide 2.2: 20 °C 2.3: pH > 6 3.1: dichloromethane; water 4.1: sodium 2-ethylhexanoic acid / ethanol; water View Scheme |
methyl (2S,5R)-5-benzyloxyaminopiperidine-2-carboxylate oxalate
(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: potassium hydrogencarbonate / water; 2-methyltetrahydrofuran 1.2: -5 - -3 °C 2.1: ammonium carbamate / Novozyme 435 / acetonitrile / 40 °C / Enzymatic reaction 3.1: triethylamine; hydrogen; sulfur trioxide trimethylamine complex / palladium-on-charcoal / isopropyl alcohol; water 4.1: sodium 2-ethylhexanoic acid / ethanol; water View Scheme | |
Multi-step reaction with 4 steps 1: ammonia / methanol / 20 °C 2: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C 3: triethylamine; hydrogen; sulfur trioxide trimethylamine complex / palladium-on-charcoal / isopropyl alcohol; water 4: sodium 2-ethylhexanoic acid / ethanol; water View Scheme | |
Multi-step reaction with 5 steps 1.1: potassium hydrogencarbonate / water; 2-methyltetrahydrofuran 1.2: -5 - -3 °C 2.1: ammonium carbamate / Novozyme 435 / acetonitrile / 40 °C / Enzymatic reaction 3.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr 4.1: water 5.1: sodium 2-ethylhexanoic acid / ethanol; water View Scheme |
ethyl (S)-2-((tert-butoxycarbonyl)amino)-6-(dimethyl(oxo)-λ6-sulfanylidene)-5-oxohexanoate
(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: ethyl acetate / Reflux 2.1: methanesulfonic acid / ethyl acetate / 42 °C 2.2: 52 °C 3.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C 3.3: 40 - 45 °C 4.1: ammonia / methanol / 20 °C 5.1: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C 6.1: triethylamine; hydrogen; sulfur trioxide trimethylamine complex / palladium-on-charcoal / isopropyl alcohol; water 7.1: sodium 2-ethylhexanoic acid / ethanol; water View Scheme | |
Multi-step reaction with 7 steps 1.1: ethyl acetate / Reflux 2.1: methanesulfonic acid / ethyl acetate / 42 °C 2.2: 52 °C 3.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C 3.3: 40 - 45 °C 4.1: 3-Methylpyridine / dichloromethane / 0 °C 5.1: ammonium carbamate / Novozyme 435 / dichloromethane; acetonitrile / 40 °C / Enzymatic reaction 6.1: triethylamine; hydrogen; sulfur trioxide trimethylamine complex / palladium-on-charcoal / isopropyl alcohol; water 7.1: sodium 2-ethylhexanoic acid / ethanol; water View Scheme | |
Multi-step reaction with 8 steps 1.1: ethyl acetate / Reflux 2.1: methanesulfonic acid / ethyl acetate / 42 °C 2.2: 52 °C 3.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C 3.3: 40 - 45 °C 4.1: ammonia / methanol / 20 °C 5.1: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C 6.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr 7.1: water 8.1: sodium 2-ethylhexanoic acid / ethanol; water View Scheme |
C20H29ClN2O5
(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: methanesulfonic acid / ethyl acetate / 42 °C 1.2: 52 °C 2.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C 2.3: 40 - 45 °C 3.1: ammonia / methanol / 20 °C 4.1: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C 5.1: triethylamine; hydrogen; sulfur trioxide trimethylamine complex / palladium-on-charcoal / isopropyl alcohol; water 6.1: sodium 2-ethylhexanoic acid / ethanol; water View Scheme | |
Multi-step reaction with 6 steps 1.1: methanesulfonic acid / ethyl acetate / 42 °C 1.2: 52 °C 2.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C 2.3: 40 - 45 °C 3.1: 3-Methylpyridine / dichloromethane / 0 °C 4.1: ammonium carbamate / Novozyme 435 / dichloromethane; acetonitrile / 40 °C / Enzymatic reaction 5.1: triethylamine; hydrogen; sulfur trioxide trimethylamine complex / palladium-on-charcoal / isopropyl alcohol; water 6.1: sodium 2-ethylhexanoic acid / ethanol; water View Scheme | |
Multi-step reaction with 7 steps 1.1: methanesulfonic acid / ethyl acetate / 42 °C 1.2: 52 °C 2.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C 2.3: 40 - 45 °C 3.1: ammonia / methanol / 20 °C 4.1: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C 5.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr 6.1: water 7.1: sodium 2-ethylhexanoic acid / ethanol; water View Scheme |
5-benzyloxyiminopiperidine-2S-carboxylic acid ethyl ester
(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C 1.3: 40 - 45 °C 2.1: 3-Methylpyridine / dichloromethane / 0 °C 3.1: ammonium carbamate / Novozyme 435 / dichloromethane; acetonitrile / 40 °C / Enzymatic reaction 4.1: triethylamine; hydrogen; sulfur trioxide trimethylamine complex / palladium-on-charcoal / isopropyl alcohol; water 5.1: sodium 2-ethylhexanoic acid / ethanol; water View Scheme | |
Multi-step reaction with 5 steps 1.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C 1.3: 40 - 45 °C 2.1: ammonia / methanol / 20 °C 3.1: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C 4.1: triethylamine; hydrogen; sulfur trioxide trimethylamine complex / palladium-on-charcoal / isopropyl alcohol; water 5.1: sodium 2-ethylhexanoic acid / ethanol; water View Scheme | |
Multi-step reaction with 6 steps 1.1: sodium tetrahydroborate; sulfuric acid; propionic acid / ethyl acetate / -20 °C 1.3: 40 - 45 °C 2.1: ammonia / methanol / 20 °C 3.1: N-ethyl-N,N-diisopropylamine; (fluorenylmethoxy)carbonyl chloride / chlorobenzene / 30 °C 4.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr 5.1: water 6.1: sodium 2-ethylhexanoic acid / ethanol; water View Scheme |
(2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octan-2-carboxylic acid ethyl ester
(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: ammonium carbamate / Novozyme 435 / dichloromethane; acetonitrile / 40 °C / Enzymatic reaction 2: triethylamine; hydrogen; sulfur trioxide trimethylamine complex / palladium-on-charcoal / isopropyl alcohol; water 3: sodium 2-ethylhexanoic acid / ethanol; water View Scheme | |
Multi-step reaction with 4 steps 1.1: ammonium carbamate / Novozyme 435 / dichloromethane; acetonitrile / 40 °C / Enzymatic reaction 2.1: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide 2.2: 20 °C 2.3: pH > 6 3.1: dichloromethane; water 4.1: sodium 2-ethylhexanoic acid / ethanol; water View Scheme | |
Multi-step reaction with 4 steps 1: ammonium carbamate / Novozyme 435 / dichloromethane; acetonitrile / 40 °C / Enzymatic reaction 2: hydrogen / 5% Pd-C / dichloromethane; N,N-dimethyl-formamide / 2250.23 Torr 3: water 4: sodium 2-ethylhexanoic acid / ethanol; water View Scheme | |
Multi-step reaction with 4 steps 1.1: lithium hydroxide / 1 h / 10 - 20 °C 2.1: hydrogenchloride / dichloromethane; water 3.1: ammonia; sodium sulfate; triethylamine / -25 - 5 °C 4.1: 10 wt% Pd(OH)2 on carbon; ammonium formate / 5 h / 30 - 40 °C / Inert atmosphere 4.2: 4 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 1 h / -5 - 5 °C 2.1: triethylamine; isobutyl chloroformate; ammonium hydroxide / dichloromethane / 1 h / -10 - 20 °C 3.1: triethylamine; triethylamine sulfur trioxide; palladium 10% on activated carbon; hydrogen / isopropyl alcohol; water / 20 °C / Sealed tube 3.2: 1 h / 20 °C / Sealed tube 4.1: sodium isooctanoate / water; ethanol / 4 h / 35 - 40 °C View Scheme |
(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt
tetra(n-butyl)ammonium hydroxide
({[(2S,5R)-2-carbamoyl-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3,2,1]-oct-6-yl]oxy}sulfonyl)tetrabutylammonium salt
Conditions | Yield |
---|---|
In water at 20 - 25℃; | 91.1% |
(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt
tetrabutylammonium acetate
({[(2S,5R)-2-carbamoyl-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3,2,1]-oct-6-yl]oxy}sulfonyl)tetrabutylammonium salt
Conditions | Yield |
---|---|
In water at 20 - 25℃; | 89% |
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