We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO
Cas:1198-97-6
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:1198-97-6
Min.Order:1 Gram
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Type:Manufacturers
inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
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Type:Trading Company
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryProduct Name: 4-Phenyl-2-pyrrolidinone Synonyms: 4-phenyl-2-pyrrolidinon;4-phenylpyrrolidone-2;4-PHENYL-2-PYRROLIDINONE;4-Phenyl-2-pyrrolidone;4-PHENYL-2-PYRIOLIDONE;4-phenylpyrrolidin-2-one;2-Pyrrolidinone
Cas:1198-97-6
Min.Order:5 Metric Ton
FOB Price: $1.0 / 2.0
Type:Other
inquiryAppearance:Off-White to Pale Yellow Solid Storage:Room temperature Package:25kg/Barrel Application:Chemicals Transportation:Express/Sea/Air Port:Any port in China
Cas:1198-97-6
Min.Order:1 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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Min.Order:1 Kilogram
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inquiry4-Phenyl-2-pyrrolidinone CAS:1198-97-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic i
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Min.Order:1 Gram
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
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Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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inquiry4-Phenyl-2-pyrrolidinone Basic information Product Name: 4-Phenyl-2-pyrrolidinone Synonyms: 4-phenyl-2-pyrrolidinon;2-tert-butyl-4,6-dinitro-N-(2,4,6-tribromophenyl)aniline;4-Phenylpyrrolidin-2-one 95%;4-phenylpyrrolidone-2;4-PHENYL-2-PYRROLID
Cas:1198-97-6
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thinkchem specializes in exp
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Min.Order:1 Kilogram
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Type:Trading Company
inquiryHunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as
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inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
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Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry2-oxo-4-phenylpyrrolidine-3-carboxylic acid
4-phenylpyrrolidin-2-one
Conditions | Yield |
---|---|
In toluene for 5h; Reflux; | 100% |
at 190℃; for 0.5h; | 58% |
at 175℃; |
4-nitro-3-phenylbutanoic acid methyl ester
4-phenylpyrrolidin-2-one
Conditions | Yield |
---|---|
With palladium 10% on activated carbon; hydrogen In methanol at 60℃; under 45004.5 Torr; | 92% |
With hydrogen; platinum(IV) oxide In methanol for 20h; | 72% |
With hydrogen; nickel In methanol at 60℃; |
4-phenylpyrrolidin-2-one
Conditions | Yield |
---|---|
With sodium tetrahydroborate; nickel dichloride In tetrahydrofuran; methanol at 0 - 20℃; for 1h; | 92% |
ethyl 3-phenyl-4-nitrobutanoate
4-phenylpyrrolidin-2-one
Conditions | Yield |
---|---|
With sodium tetrahydroborate; nickel(II) chloride hexahydrate In ethanol at 0℃; for 2h; | 88% |
With sodium tetrahydroborate; nickel(II) chloride hexahydrate In ethanol at 0℃; for 2h; | 82% |
With hydrogen; palladium on activated charcoal 1.) 2.) toluene, reflux; Yield given. Multistep reaction; | |
Stage #1: ethyl 3-phenyl-4-nitrobutanoate With hydrogen In ethanol at 20℃; under 1034.32 Torr; Stage #2: In ethanol; toluene Reflux; |
4-phenylpyrrolidin-2-one
Conditions | Yield |
---|---|
Stage #1: C11H11N3O3 In chloroform at 60℃; for 3h; Inert atmosphere; Stage #2: With dmap In chloroform at 20℃; for 2h; Inert atmosphere; | 87% |
4-phenylpyrrolidin-2-one
Conditions | Yield |
---|---|
With sodium tetrahydroborate; nickel(II) chloride hexahydrate; water In dichloromethane at -10 - 30℃; for 5h; Concentration; Reagent/catalyst; Temperature; | 85% |
4-amino-3-phenylbutanoic acid methyl ester
4-phenylpyrrolidin-2-one
Conditions | Yield |
---|---|
With triethylamine In ethanol Reflux; | 83% |
(+/-)-4-nitro-3-phenylbutyric acid 4'-(4-nitro-3-phenylbutyryloxymethyl)-[2,2']bipyridinyl-4-ylmethyl ester
4-phenylpyrrolidin-2-one
Conditions | Yield |
---|---|
With polymer-supported borohydride resin; nickel dichloride In dichloromethane at 20℃; | 60% |
4-phenylpyrrolidin-2-one
Conditions | Yield |
---|---|
With hydrazine hydrate In ethanol at 95℃; for 6h; Sealed tube; | 59% |
3-cyano-3-phenylpropanoic acid ethyl ester
4-phenylpyrrolidin-2-one
Conditions | Yield |
---|---|
Stage #1: 3-cyano-3-phenylpropanoic acid ethyl ester With sodium tetrahydroborate; cobalt(II) chloride hexahydrate In tetrahydrofuran; water at 0 - 20℃; for 72h; Stage #2: With ammonia In tetrahydrofuran; water | 57% |
Multi-step reaction with 2 steps 1: H2, conc. HCl / 10percent Pd/C / methanol / 2068.6 Torr 2: Et3N / toluene / Heating View Scheme |
Conditions | Yield |
---|---|
With aluminum (III) chloride; sodium chloride at 0 - 180℃; under 750.075 Torr; | 44% |
4-phenylpyrrolidin-2-one
Conditions | Yield |
---|---|
With hydrogenchloride; zinc In ethanol Heating; | 36% |
(2-nitro-1-phenyl-ethyl)-malonic acid dimethyl ester
4-phenylpyrrolidin-2-one
Conditions | Yield |
---|---|
With palladium on activated carbon; hydrogen In o-xylene at 130℃; under 11251.1 Torr; for 18h; Catalytic behavior; | 35% |
Multi-step reaction with 3 steps 1: hydrogen / methanol / 2.5 h / 20 °C / 3102.97 Torr 2: sodium hydroxide / ethanol / 48 h / 20 °C 3: toluene / 5 h / Reflux View Scheme |
Conditions | Yield |
---|---|
With aluminum (III) chloride; sodium chloride at 0 - 180℃; under 750.075 Torr; | 32% |
2-oxo-4-phenyl-3-ethoxycarbonylpyrrolidine
4-phenylpyrrolidin-2-one
Conditions | Yield |
---|---|
With hydrogenchloride; ethanol; water | |
Multi-step reaction with 2 steps 1: ethanolic KOH 2: 175 °C View Scheme | |
With sodium carbonate for 6h; Reagent/catalyst; Reflux; | 3.3 g |
Conditions | Yield |
---|---|
With potassium hydroxide |
4-phenylpyrrolidin-2-one
Conditions | Yield |
---|---|
With triethylamine In toluene Heating; |
4-phenylpyrrolidin-2-one
Conditions | Yield |
---|---|
With diethyl ether; nickel at 70 - 90℃; Hydrogenation; |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 96 percent / 1,1,3,3-tetramethylguanidine / 3 h / Heating 2: 72 percent / H2 / PtO2 / methanol / 20 h View Scheme | |
Multi-step reaction with 2 steps 1: 1,1,3,3-tetramethylguanidine / 70 °C 2: H2 / Raney nickel / methanol / 60 °C View Scheme | |
Multi-step reaction with 2 steps 1: 1,8-diazabicyclo[5.4.0]undec-7-ene / methanol 2: hydrogen / platinum(IV) oxide / ethanol View Scheme | |
Multi-step reaction with 3 steps 1: N,N,N',N'-tetramethylguanidine / 42 h / 20 °C 2: palladium 10% on activated carbon; acetic acid; hydrogen / dichloromethane / 20 °C 3: triethylamine / ethanol / Reflux View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: methanol; H2O / 60 °C 2: H2, conc. HCl / 10percent Pd/C / methanol / 2068.6 Torr 3: Et3N / toluene / Heating View Scheme |
3-methoxycarbonyl-4-phenyl-2-pyrrolidone
4-phenylpyrrolidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 89.6 percent / 10percent aq. KOH / 5 h / Heating 2: 58 percent / 0.5 h / 190 °C View Scheme | |
Multi-step reaction with 2 steps 1: sodium hydroxide / ethanol / 48 h / 20 °C 2: toluene / 5 h / Reflux View Scheme |
4-phenylpyrrolidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: acetic acid / chloroform / 1 h / 0 - 20 °C 1.2: 20 °C 2.1: trifluoroacetic acid / 1,2-dichloro-ethane / 2 h / 80 °C 3.1: nickel dichloride; sodium tetrahydroborate / methanol; tetrahydrofuran / 1 h / 0 - 20 °C View Scheme |
4-phenylpyrrolidin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: trifluoroacetic acid / 1,2-dichloro-ethane / 2 h / 80 °C 2: nickel dichloride; sodium tetrahydroborate / methanol; tetrahydrofuran / 1 h / 0 - 20 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: cesium fluoride; tetrabutyl-ammonium chloride; bis-triphenylphosphine-palladium(II) chloride / toluene; water / 18 h / 20 °C / Inert atmosphere 2.1: acetic acid / chloroform / 1 h / 0 - 20 °C 2.2: 20 °C 3.1: trifluoroacetic acid / 1,2-dichloro-ethane / 2 h / 80 °C 4.1: nickel dichloride; sodium tetrahydroborate / methanol; tetrahydrofuran / 1 h / 0 - 20 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 20 °C 2.1: hydrogen / ethanol / 20 °C / 1034.32 Torr 2.2: Reflux View Scheme | |
Multi-step reaction with 2 steps 1: sodium hydroxide / methanol; water / 24 h / 20 - 30 °C 2: nickel(II) chloride hexahydrate; water; sodium tetrahydroborate / dichloromethane / 5 h / -10 - 30 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: tetrahydrofuran / 20 °C 2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 20 °C 3.1: hydrogen / ethanol / 20 °C / 1034.32 Torr 3.2: Reflux View Scheme | |
Multi-step reaction with 2 steps 1: aminopropyl-silica-based catalyst; dimethylaminopropyl-silica-based solid / o-xylene / 18 h / 70 °C / Green chemistry 2: palladium on activated carbon; hydrogen / o-xylene / 18 h / 130 °C / 11251.1 Torr View Scheme | |
Multi-step reaction with 3 steps 1.1: potassium tert-butylate / toluene; methanol / 0.17 h / 20 °C / 4500.45 Torr / Inert atmosphere 1.2: 0.11 h / 25 °C / 4500.45 Torr / Inert atmosphere 2.1: tetrabutyl ammonium fluoride / toluene; tetrahydrofuran / 1 h / 50 °C / 6000.6 Torr 3.1: hydrogen; palladium 10% on activated carbon / methanol / 60 °C / 45004.5 Torr View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: calcined hydrotalcite / ethanol / 24 h / Reflux 2: nickel(II) chloride hexahydrate; sodium tetrahydroborate / ethanol / 2 h / 0 °C View Scheme | |
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 24 h / 25 °C 2: calcined hydrotalcite / 24 h / Reflux 3: nickel(II) chloride hexahydrate; sodium tetrahydroborate / ethanol / 2 h / 0 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; sodium hypochlorite; potassium bromide / water; dichloromethane / 0.21 h / 0 °C 2.1: potassium tert-butylate / toluene; methanol / 0.17 h / 20 °C / 4500.45 Torr / Inert atmosphere 2.2: 0.11 h / 25 °C / 4500.45 Torr / Inert atmosphere 3.1: tetrabutyl ammonium fluoride / toluene; tetrahydrofuran / 1 h / 50 °C / 6000.6 Torr 4.1: hydrogen; palladium 10% on activated carbon / methanol / 60 °C / 45004.5 Torr View Scheme |
4-phenylpyrrolidin-2-one
propargyl bromide
N-propargyl-4-phenyl-2-pyrrolidone
Conditions | Yield |
---|---|
With potassium hydroxide; tetrabutylammomium bromide In tetrahydrofuran at 0 - 20℃; for 6h; | 97% |
4-phenylpyrrolidin-2-one
(R)-1-(1-naphthyl)ethyl isocyanate
N-<(R)-1-(1-naphthyl)ethyl>-4-phenyl-2-pyrrolidone-1-carboxamide
Conditions | Yield |
---|---|
In benzene for 24h; Heating; | 95% |
4-phenylpyrrolidin-2-one
1,1,1,3,3,3-hexamethyl-disilazane
4-phenyl-1-(trimethylsilyl)-2-pyrrolidinone
Conditions | Yield |
---|---|
With hydrogenchloride for 0.333333h; Heating; | 90% |
4-phenylpyrrolidin-2-one
Conditions | Yield |
---|---|
With hydrogenchloride; water for 12h; Reflux; | 88% |
With hydrogenchloride In water for 12h; Reflux; | 88% |
With hydrogenchloride In water for 16h; Sealed tube; Reflux; | 65% |
With hydrogenchloride; water In water for 16h; Reflux; | 55% |
4-phenylpyrrolidin-2-one
methyl iodide
1-methyl-4-phenyl-pyrrolidin-2-one
Conditions | Yield |
---|---|
Stage #1: 4-phenylpyrrolidin-2-one With sodium hydride In tetrahydrofuran; mineral oil for 0.5h; Sealed tube; Inert atmosphere; Stage #2: methyl iodide In tetrahydrofuran; mineral oil at 20℃; Sealed tube; Inert atmosphere; | 88% |
4-phenylpyrrolidin-2-one
methyl chloroacetate
methyl-2-oxo-4-phenylpyrrolidine-1-acetate
Conditions | Yield |
---|---|
Stage #1: 4-phenylpyrrolidin-2-one With potassium tert-butylate In N,N-dimethyl-formamide at -10℃; for 2h; Stage #2: methyl chloroacetate In N,N-dimethyl-formamide at -10 - 0℃; for 2h; Concentration; Temperature; Solvent; | 84% |
With sodium methylate 1.) toluene, 150-160 deg C, 2.) toluene, 60-70 deg C, 2 h; Yield given. Multistep reaction; | |
In tetrahydrofuran; water; mineral oil |
4-phenylpyrrolidin-2-one
3-bromo-5-[methyl(methylsulfonyl)amino]benzoic acid methyl ester
3-[methyl(methylsulfonyl)amino]-5-(2-oxo-4-phenylpyrrolidine-1-yl)benzoic acid methyl ester
Conditions | Yield |
---|---|
With caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 110℃; for 7h; | 82% |
4-phenylpyrrolidin-2-one
triethyloxonium fluoroborate
Ethoxy-2 phenyl-4 Δ1-pyrroline
Conditions | Yield |
---|---|
81% |
Conditions | Yield |
---|---|
With triethylamine In toluene | 76.5% |
formaldehyd
4-phenylpyrrolidin-2-one
1-chloromethyl-4-phenylpyrrolidin-2-one
Conditions | Yield |
---|---|
With chloro-trimethyl-silane for 1h; Heating; | 67.5% |
Conditions | Yield |
---|---|
With thionyl chloride; triethylamine In toluene | A 58.5% B 65.4% |
Conditions | Yield |
---|---|
With copper(l) iodide; potassium carbonate; 1,3-bis(methylamino)propane In 1,4-dioxane for 24h; Reflux; | 60% |
4-phenylpyrrolidin-2-one
4-iodo-N-(quinolin-8-yl)benzamide
C26H21N3O2
Conditions | Yield |
---|---|
With copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine In 1,4-dioxane at 140℃; Microwave irradiation; | 59% |
Conditions | Yield |
---|---|
In tetrahydrofuran | 57% |
4-phenylpyrrolidin-2-one
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 80℃; for 1h; Inert atmosphere; | 55% |
4-phenylpyrrolidin-2-one
benzyl bromide
1-benzyl-4-phenylpyrrolidin-2-one
Conditions | Yield |
---|---|
With 18-crown-6 ether; sodium hydride In tetrahydrofuran at 0 - 20℃; for 0.5h; | 52% |
With sodium hydride 1.) xylene, reflux, 5 h, 2.) xylene, reflux, 4 h; Yield given. Multistep reaction; |
4-phenylpyrrolidin-2-one
1-(2,2,2-trifluoroacetyl)indolin-5-ylsulfonyl chloride
Conditions | Yield |
---|---|
Stage #1: 4-phenylpyrrolidin-2-one With n-butyllithium In tetrahydrofuran for 0.5h; Stage #2: 1-(2,2,2-trifluoroacetyl)indolin-5-ylsulfonyl chloride In tetrahydrofuran at 0℃; for 4h; | 45% |
4-phenylpyrrolidin-2-one
4-phenyl-2-pyrrolidinethione
Conditions | Yield |
---|---|
With diphosphorus pentasulfide In o-xylene Heating; | 40% |
Conditions | Yield |
---|---|
Stage #1: 4-phenylpyrrolidin-2-one With sodium hydride In N,N-dimethyl-formamide at 20 - 50℃; for 1h; Metallation; Stage #2: 2-(diethylamino)ethyl chloride In N,N-dimethyl-formamide at 80℃; for 8h; Alkylation; Stage #3: oxalic acid In diethyl ether; ethanol acid-base reaction; | 37.5% |
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