4-Phenyl-2-pyrrolidinone supplier

Name
4-Phenyl-2-pyrrolidinone
EINECS
CAS No. 1198-97-6
Article Data35
CAS DataBase
Density 1.108g/cm³
Solubility
Melting Point 72.0～78.0℃
Formula C10H11 N O
Boiling Point 362.3°Cat760mmHg
Molecular Weight 161.203
Flash Point 212.4°C
Transport Information
Appearance
Safety Poison by intraperitoneal route. When heated to decomposition it emits toxic fumes of NO_x.
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 4-Phenyl-2-pyrrolidinone;4-Phenyl-2-pyrrolidone; b-Phenyl-g-aminobutyricacid lactam
PSA 29.10000
LogP 1.61890

Synthetic route

: 77519-55-2
2-oxo-4-phenylpyrrolidine-3-carboxylic acid

: 1198-97-6
4-phenylpyrrolidin-2-one

Conditions

Conditions	Yield
In toluene for 5h; Reflux;	100%
at 190℃; for 0.5h;	58%
at 175℃;

: 34687-03-1
4-nitro-3-phenylbutanoic acid methyl ester

: 1198-97-6
4-phenylpyrrolidin-2-one

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol at 60℃; under 45004.5 Torr;	92%
With hydrogen; platinum(IV) oxide In methanol for 20h;	72%
With hydrogen; nickel In methanol at 60℃;

: 3-chloro-4-phenyl-1H-pyrrol-2(5H)-one

: 1198-97-6
4-phenylpyrrolidin-2-one

Conditions

Conditions	Yield
With sodium tetrahydroborate; nickel dichloride In tetrahydrofuran; methanol at 0 - 20℃; for 1h;	92%

: 41441-40-1
ethyl 3-phenyl-4-nitrobutanoate

: 1198-97-6
4-phenylpyrrolidin-2-one

Conditions

Conditions	Yield
With sodium tetrahydroborate; nickel(II) chloride hexahydrate In ethanol at 0℃; for 2h;	88%
With sodium tetrahydroborate; nickel(II) chloride hexahydrate In ethanol at 0℃; for 2h;	82%
With hydrogen; palladium on activated charcoal 1.) 2.) toluene, reflux; Yield given. Multistep reaction;
Stage #1: ethyl 3-phenyl-4-nitrobutanoate With hydrogen In ethanol at 20℃; under 1034.32 Torr; Stage #2: In ethanol; toluene Reflux;

: C11H11N3O3

: 1198-97-6
4-phenylpyrrolidin-2-one

Conditions

Conditions	Yield
Stage #1: C11H11N3O3 In chloroform at 60℃; for 3h; Inert atmosphere; Stage #2: With dmap In chloroform at 20℃; for 2h; Inert atmosphere;	87%

: 4-nitro-3-phenylbutanoic acid ethyl ester

: 1198-97-6
4-phenylpyrrolidin-2-one

Conditions

Conditions	Yield
With sodium tetrahydroborate; nickel(II) chloride hexahydrate; water In dichloromethane at -10 - 30℃; for 5h; Concentration; Reagent/catalyst; Temperature;	85%

: 84872-79-7
4-amino-3-phenylbutanoic acid methyl ester

: 1198-97-6
4-phenylpyrrolidin-2-one

Conditions

Conditions	Yield
With triethylamine In ethanol Reflux;	83%

: 866789-27-7
(+/-)-4-nitro-3-phenylbutyric acid 4'-(4-nitro-3-phenylbutyryloxymethyl)-[2,2']bipyridinyl-4-ylmethyl ester

: 1198-97-6
4-phenylpyrrolidin-2-one

Conditions

Conditions	Yield
With polymer-supported borohydride resin; nickel dichloride In dichloromethane at 20℃;	60%

: 4-(1,3-dioxoisoindolin-2-yl)-3-phenyl-N-(quinolin-8-yl)butanamide

: 1198-97-6
4-phenylpyrrolidin-2-one

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol at 95℃; for 6h; Sealed tube;	59%

: 14025-83-3
3-cyano-3-phenylpropanoic acid ethyl ester

: 1198-97-6
4-phenylpyrrolidin-2-one

Conditions

Conditions	Yield
Stage #1: 3-cyano-3-phenylpropanoic acid ethyl ester With sodium tetrahydroborate; cobalt(II) chloride hexahydrate In tetrahydrofuran; water at 0 - 20℃; for 72h; Stage #2: With ammonia In tetrahydrofuran; water	57%
Multi-step reaction with 2 steps 1: H2, conc. HCl / 10percent Pd/C / methanol / 2068.6 Torr 2: Et3N / toluene / Heating View Scheme

: 616-45-5
2-pyrrolidinon

: 108-86-1
bromobenzene

: 1198-97-6
4-phenylpyrrolidin-2-one

Conditions

Conditions	Yield
With aluminum (III) chloride; sodium chloride at 0 - 180℃; under 750.075 Torr;	44%

4-nitro-3-phenylbutanoic acid polyglyceryl ester: 4-nitro-3-phenylbutanoic acid polyglyceryl ester

: 1198-97-6
4-phenylpyrrolidin-2-one

Conditions

Conditions	Yield
With hydrogenchloride; zinc In ethanol Heating;	36%

: 55790-16-4
(2-nitro-1-phenyl-ethyl)-malonic acid dimethyl ester

: 1198-97-6
4-phenylpyrrolidin-2-one

Conditions

Conditions	Yield
With palladium on activated carbon; hydrogen In o-xylene at 130℃; under 11251.1 Torr; for 18h; Catalytic behavior;	35%
Multi-step reaction with 3 steps 1: hydrogen / methanol / 2.5 h / 20 °C / 3102.97 Torr 2: sodium hydroxide / ethanol / 48 h / 20 °C 3: toluene / 5 h / Reflux View Scheme

: 616-45-5
2-pyrrolidinon

: 108-90-7
chlorobenzene

: 1198-97-6
4-phenylpyrrolidin-2-one

Conditions

Conditions	Yield
With aluminum (III) chloride; sodium chloride at 0 - 180℃; under 750.075 Torr;	32%

: 52450-32-5
2-oxo-4-phenyl-3-ethoxycarbonylpyrrolidine

: 1198-97-6
4-phenylpyrrolidin-2-one

Conditions

Conditions	Yield
With hydrogenchloride; ethanol; water
Multi-step reaction with 2 steps 1: ethanolic KOH 2: 175 °C View Scheme
With sodium carbonate for 6h; Reagent/catalyst; Reflux;	3.3 g

: 1078-21-3
4-amino-3-phenylbutanoic acid

: 1198-97-6
4-phenylpyrrolidin-2-one

Conditions

Conditions	Yield
With potassium hydroxide

: ethyl 4-amino-3-phenylbutanoate hydrochloride

: 1198-97-6
4-phenylpyrrolidin-2-one

Conditions

Conditions	Yield
With triethylamine In toluene Heating;

(+-)-3-cyano-3-phenyl-propionic acid ethyl ester: (+-)-3-cyano-3-phenyl-propionic acid ethyl ester

: 1198-97-6
4-phenylpyrrolidin-2-one

Conditions

Conditions	Yield
With diethyl ether; nickel at 70 - 90℃; Hydrogenation;

: 103-26-4
Methyl cinnamate

: 1198-97-6
4-phenylpyrrolidin-2-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 96 percent / 1,1,3,3-tetramethylguanidine / 3 h / Heating 2: 72 percent / H2 / PtO2 / methanol / 20 h View Scheme
Multi-step reaction with 2 steps 1: 1,1,3,3-tetramethylguanidine / 70 °C 2: H2 / Raney nickel / methanol / 60 °C View Scheme
Multi-step reaction with 2 steps 1: 1,8-diazabicyclo[5.4.0]undec-7-ene / methanol 2: hydrogen / platinum(IV) oxide / ethanol View Scheme
Multi-step reaction with 3 steps 1: N,N,N',N'-tetramethylguanidine / 42 h / 20 °C 2: palladium 10% on activated carbon; acetic acid; hydrogen / dichloromethane / 20 °C 3: triethylamine / ethanol / Reflux View Scheme

: 5292-53-5
diethyl benzalmalonate

: 1198-97-6
4-phenylpyrrolidin-2-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: methanol; H2O / 60 °C 2: H2, conc. HCl / 10percent Pd/C / methanol / 2068.6 Torr 3: Et3N / toluene / Heating View Scheme

: 55790-17-5
3-methoxycarbonyl-4-phenyl-2-pyrrolidone

: 1198-97-6
4-phenylpyrrolidin-2-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 89.6 percent / 10percent aq. KOH / 5 h / Heating 2: 58 percent / 0.5 h / 190 °C View Scheme
Multi-step reaction with 2 steps 1: sodium hydroxide / ethanol / 48 h / 20 °C 2: toluene / 5 h / Reflux View Scheme

: 3-chloro-5-hydroxy-4-phenylfuran-2(5H)-one

: 1198-97-6
4-phenylpyrrolidin-2-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: acetic acid / chloroform / 1 h / 0 - 20 °C 1.2: 20 °C 2.1: trifluoroacetic acid / 1,2-dichloro-ethane / 2 h / 80 °C 3.1: nickel dichloride; sodium tetrahydroborate / methanol; tetrahydrofuran / 1 h / 0 - 20 °C View Scheme

: 3-chloro-1-(2,4-dimethoxybenzyl)-4-phenyl-1H-pyrrol-2(5H)-one

: 1198-97-6
4-phenylpyrrolidin-2-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: trifluoroacetic acid / 1,2-dichloro-ethane / 2 h / 80 °C 2: nickel dichloride; sodium tetrahydroborate / methanol; tetrahydrofuran / 1 h / 0 - 20 °C View Scheme

: 98-80-6
phenylboronic acid

: 1198-97-6
4-phenylpyrrolidin-2-one

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: cesium fluoride; tetrabutyl-ammonium chloride; bis-triphenylphosphine-palladium(II) chloride / toluene; water / 18 h / 20 °C / Inert atmosphere 2.1: acetic acid / chloroform / 1 h / 0 - 20 °C 2.2: 20 °C 3.1: trifluoroacetic acid / 1,2-dichloro-ethane / 2 h / 80 °C 4.1: nickel dichloride; sodium tetrahydroborate / methanol; tetrahydrofuran / 1 h / 0 - 20 °C View Scheme

Yield

Multi-step reaction with 4 steps
1.1: cesium fluoride; tetrabutyl-ammonium chloride; bis-triphenylphosphine-palladium(II) chloride / toluene; water / 18 h / 20 °C / Inert atmosphere
2.1: acetic acid / chloroform / 1 h / 0 - 20 °C
2.2: 20 °C
3.1: trifluoroacetic acid / 1,2-dichloro-ethane / 2 h / 80 °C
4.1: nickel dichloride; sodium tetrahydroborate / methanol; tetrahydrofuran / 1 h / 0 - 20 °C
View Scheme

: 103-36-6
ethyl 3-phenyl-2-propenoate

: 1198-97-6
4-phenylpyrrolidin-2-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 20 °C 2.1: hydrogen / ethanol / 20 °C / 1034.32 Torr 2.2: Reflux View Scheme
Multi-step reaction with 2 steps 1: sodium hydroxide / methanol; water / 24 h / 20 - 30 °C 2: nickel(II) chloride hexahydrate; water; sodium tetrahydroborate / dichloromethane / 5 h / -10 - 30 °C View Scheme

: 100-52-7
benzaldehyde

: 1198-97-6
4-phenylpyrrolidin-2-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: tetrahydrofuran / 20 °C 2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 20 °C 3.1: hydrogen / ethanol / 20 °C / 1034.32 Torr 3.2: Reflux View Scheme
Multi-step reaction with 2 steps 1: aminopropyl-silica-based catalyst; dimethylaminopropyl-silica-based solid / o-xylene / 18 h / 70 °C / Green chemistry 2: palladium on activated carbon; hydrogen / o-xylene / 18 h / 130 °C / 11251.1 Torr View Scheme
Multi-step reaction with 3 steps 1.1: potassium tert-butylate / toluene; methanol / 0.17 h / 20 °C / 4500.45 Torr / Inert atmosphere 1.2: 0.11 h / 25 °C / 4500.45 Torr / Inert atmosphere 2.1: tetrabutyl ammonium fluoride / toluene; tetrahydrofuran / 1 h / 50 °C / 6000.6 Torr 3.1: hydrogen; palladium 10% on activated carbon / methanol / 60 °C / 45004.5 Torr View Scheme

: 102-96-5
(2-nitroethenyl)benzene

: 1198-97-6
4-phenylpyrrolidin-2-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: calcined hydrotalcite / ethanol / 24 h / Reflux 2: nickel(II) chloride hexahydrate; sodium tetrahydroborate / ethanol / 2 h / 0 °C View Scheme
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 24 h / 25 °C 2: calcined hydrotalcite / 24 h / Reflux 3: nickel(II) chloride hexahydrate; sodium tetrahydroborate / ethanol / 2 h / 0 °C View Scheme

: 100-51-6
benzyl alcohol

: 1198-97-6
4-phenylpyrrolidin-2-one

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; sodium hypochlorite; potassium bromide / water; dichloromethane / 0.21 h / 0 °C 2.1: potassium tert-butylate / toluene; methanol / 0.17 h / 20 °C / 4500.45 Torr / Inert atmosphere 2.2: 0.11 h / 25 °C / 4500.45 Torr / Inert atmosphere 3.1: tetrabutyl ammonium fluoride / toluene; tetrahydrofuran / 1 h / 50 °C / 6000.6 Torr 4.1: hydrogen; palladium 10% on activated carbon / methanol / 60 °C / 45004.5 Torr View Scheme

Yield

Multi-step reaction with 4 steps
1.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; sodium hypochlorite; potassium bromide / water; dichloromethane / 0.21 h / 0 °C
2.1: potassium tert-butylate / toluene; methanol / 0.17 h / 20 °C / 4500.45 Torr / Inert atmosphere
2.2: 0.11 h / 25 °C / 4500.45 Torr / Inert atmosphere
3.1: tetrabutyl ammonium fluoride / toluene; tetrahydrofuran / 1 h / 50 °C / 6000.6 Torr
4.1: hydrogen; palladium 10% on activated carbon / methanol / 60 °C / 45004.5 Torr
View Scheme

: 1198-97-6
4-phenylpyrrolidin-2-one

: 106-96-7
propargyl bromide

: 137518-26-4
N-propargyl-4-phenyl-2-pyrrolidone

Conditions

Conditions	Yield
With potassium hydroxide; tetrabutylammomium bromide In tetrahydrofuran at 0 - 20℃; for 6h;	97%

: 1198-97-6
4-phenylpyrrolidin-2-one

: 42340-98-7
(R)-1-(1-naphthyl)ethyl isocyanate

: 916345-91-0
N-<(R)-1-(1-naphthyl)ethyl>-4-phenyl-2-pyrrolidone-1-carboxamide

Conditions

Conditions	Yield
In benzene for 24h; Heating;	95%

: 1198-97-6
4-phenylpyrrolidin-2-one

: 999-97-3
1,1,1,3,3,3-hexamethyl-disilazane

: 106869-48-1
4-phenyl-1-(trimethylsilyl)-2-pyrrolidinone

Conditions

Conditions	Yield
With hydrogenchloride for 0.333333h; Heating;	90%

: 1198-97-6
4-phenylpyrrolidin-2-one

Conditions

Conditions	Yield
With hydrogenchloride; water for 12h; Reflux;	88%
With hydrogenchloride In water for 12h; Reflux;	88%
With hydrogenchloride In water for 16h; Sealed tube; Reflux;	65%
With hydrogenchloride; water In water for 16h; Reflux;	55%

: 1198-97-6
4-phenylpyrrolidin-2-one

: 74-88-4
methyl iodide

: 54520-84-2
1-methyl-4-phenyl-pyrrolidin-2-one

Conditions

Conditions	Yield
Stage #1: 4-phenylpyrrolidin-2-one With sodium hydride In tetrahydrofuran; mineral oil for 0.5h; Sealed tube; Inert atmosphere; Stage #2: methyl iodide In tetrahydrofuran; mineral oil at 20℃; Sealed tube; Inert atmosphere;	88%

: 1198-97-6
4-phenylpyrrolidin-2-one

: 96-34-4
methyl chloroacetate

: 68497-63-2
methyl-2-oxo-4-phenylpyrrolidine-1-acetate

Conditions

Conditions	Yield
Stage #1: 4-phenylpyrrolidin-2-one With potassium tert-butylate In N,N-dimethyl-formamide at -10℃; for 2h; Stage #2: methyl chloroacetate In N,N-dimethyl-formamide at -10 - 0℃; for 2h; Concentration; Temperature; Solvent;	84%
With sodium methylate 1.) toluene, 150-160 deg C, 2.) toluene, 60-70 deg C, 2 h; Yield given. Multistep reaction;
In tetrahydrofuran; water; mineral oil

: 1198-97-6
4-phenylpyrrolidin-2-one

: 924650-17-9
3-bromo-5-[methyl(methylsulfonyl)amino]benzoic acid methyl ester

: 929041-94-1
3-[methyl(methylsulfonyl)amino]-5-(2-oxo-4-phenylpyrrolidine-1-yl)benzoic acid methyl ester

Conditions

Conditions	Yield
With caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 110℃; for 7h;	82%

: 1198-97-6
4-phenylpyrrolidin-2-one

: 368-39-8
triethyloxonium fluoroborate

: 22349-33-3
Ethoxy-2 phenyl-4 Δ1-pyrroline

Conditions

Conditions	Yield
	81%

: 1198-97-6
4-phenylpyrrolidin-2-one

: 4122-68-3
4-chlorophenyloxyacetyl chloride

: N-(4-chlorophenoxyacetyl)-4-phenyl-pyrrolidin-2-one

Conditions

Conditions	Yield
With triethylamine In toluene	76.5%

: 50-00-0
formaldehyd

: 1198-97-6
4-phenylpyrrolidin-2-one

: 68116-87-0
1-chloromethyl-4-phenylpyrrolidin-2-one

Conditions

Conditions	Yield
With chloro-trimethyl-silane for 1h; Heating;	67.5%

: 59-67-6
nicotinic acid

: 1198-97-6
4-phenylpyrrolidin-2-one

A: N-nicotinoyl-4-phenyl-pyrrolidin-2-one

B: N-(4-chlorobenzoyl)-4-phenyl-pyrrolidin-2-one

Conditions

Conditions	Yield
With thionyl chloride; triethylamine In toluene	A 58.5% B 65.4%

...Expand

: 1198-97-6
4-phenylpyrrolidin-2-one

: 591-50-4
iodobenzene

: 2889-64-7
1,4-diphenylpyrrolidin-2-one

Conditions

Conditions	Yield
With copper(l) iodide; potassium carbonate; 1,3-bis(methylamino)propane In 1,4-dioxane for 24h; Reflux;	60%

: 1198-97-6
4-phenylpyrrolidin-2-one

: 1203050-38-7
4-iodo-N-(quinolin-8-yl)benzamide

: 1437789-57-5
C26H21N3O2

Conditions

Conditions	Yield
With copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine In 1,4-dioxane at 140℃; Microwave irradiation;	59%

: 1198-97-6
4-phenylpyrrolidin-2-one

: 1-ethyl-4-phenyl-pyrrolidin-2-one

Conditions

Conditions	Yield
In tetrahydrofuran	57%

: 1198-97-6
4-phenylpyrrolidin-2-one

: 2-(3-cyano-4-fluorophenoxy)ethyl methanesulfonate

: 2-fluoro-5-[2-(2-oxo-4-phenylpyrrolidin-1-yl)ethoxy]benzonitrile

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 80℃; for 1h; Inert atmosphere;	55%

: 1198-97-6
4-phenylpyrrolidin-2-one

: 100-39-0
benzyl bromide

: 108303-98-6
1-benzyl-4-phenylpyrrolidin-2-one

Conditions

Conditions	Yield
With 18-crown-6 ether; sodium hydride In tetrahydrofuran at 0 - 20℃; for 0.5h;	52%
With sodium hydride 1.) xylene, reflux, 5 h, 2.) xylene, reflux, 4 h; Yield given. Multistep reaction;

: 1198-97-6
4-phenylpyrrolidin-2-one

: 210691-38-6
1-(2,2,2-trifluoroacetyl)indolin-5-ylsulfonyl chloride

: 4-phenyl-1-(1-(2,2,2-trifluoroacetyl)indolin-5-ylsulfonyl)pyrrolidin-2-one

Conditions

Conditions	Yield
Stage #1: 4-phenylpyrrolidin-2-one With n-butyllithium In tetrahydrofuran for 0.5h; Stage #2: 1-(2,2,2-trifluoroacetyl)indolin-5-ylsulfonyl chloride In tetrahydrofuran at 0℃; for 4h;	45%

: 1198-97-6
4-phenylpyrrolidin-2-one

: 22349-31-1
4-phenyl-2-pyrrolidinethione

Conditions

Conditions	Yield
With diphosphorus pentasulfide In o-xylene Heating;	40%

: 1198-97-6
4-phenylpyrrolidin-2-one

: 144-62-7
oxalic acid

: 100-35-6
2-(diethylamino)ethyl chloride

: 1-(2-diethylaminoethyl)-4-phenyl-2-pyrrolidinone oxalate

Conditions

Conditions	Yield
Stage #1: 4-phenylpyrrolidin-2-one With sodium hydride In N,N-dimethyl-formamide at 20 - 50℃; for 1h; Metallation; Stage #2: 2-(diethylamino)ethyl chloride In N,N-dimethyl-formamide at 80℃; for 8h; Alkylation; Stage #3: oxalic acid In diethyl ether; ethanol acid-base reaction;	37.5%

...Expand

4-Phenyl-2-pyrrolidinone Chemical Properties

Empirical Formula of 4-Phenylpyrrolidone-2 (CAS NO.1198-97-6): C₁₀H₁₁NO
Molecular Weight: 161.2004 g/mol
Index of Refraction: 1.55
Density: 1.108 g/cm³
Flash Point: 212.4 °C
Enthalpy of Vaporization: 60.82 kJ/mol
Boiling Point: 362.3 °C at 760 mmHg
Vapour Pressure: 1.96E-05 mmHg at 25 °C
Structure of 4-Phenylpyrrolidone-2 (CAS NO.1198-97-6):

IUPAC Name of 4-Phenylpyrrolidone-2 (CAS NO.1198-97-6): 4-Phenylpyrrolidin-2-one

4-Phenyl-2-pyrrolidinone Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mammal (species unspecified)	LD50	unreported	352mg/kg (352mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: ANALGESIA	Russian Pharmacology and Toxicology Vol. 44, Pg. 22, 1981.
mouse	LD50	intraperitoneal	325mg/kg (325mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA	Archivum Immunologiae et Therapiae Experimentalis. Vol. 23, Pg. 733, 1975.
mouse	LD50	unreported	352mg/kg (352mg/kg)	AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)" BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: MUSCLE WEAKNESS	Pharmaceutical Chemistry Journal Vol. 14, Pg. 776, 1980.

4-Phenyl-2-pyrrolidinone Safety Profile

Poison by intraperitoneal route. When heated to decomposition it emits toxic fumes of NO_x.

4-Phenyl-2-pyrrolidinone Specification

4-Phenylpyrrolidone-2 ,its cas register number is 1198-97-6. It also can be called 4-Phenyl-2-pyrrolidinone ; 2-Pyrrolidinone, 4-phenyl- ;and Phenylpyrrolidone .

Product Name

4-Phenyl-2-pyrrolidinone

Synthetic route

4-Phenyl-2-pyrrolidinone Chemical Properties

4-Phenyl-2-pyrrolidinone Toxicity Data With Reference

4-Phenyl-2-pyrrolidinone Safety Profile

4-Phenyl-2-pyrrolidinone Specification

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