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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price in China. If you are looking for the product’s supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product specifica

Donepezil

Cas:120014-06-4

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

HANGZHOU TIANYE CHEMICALS CO., LTD.

We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Specification : Donepezil CAS No:120014-06-4 As

Donepezil

Cas:120014-06-4

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

99% up by HPLC Donepezil 120014-06-4

Cas:120014-06-4

Min.Order:1 Kilogram

FOB Price: $100.0

Type:Trading Company

inquiry

Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay 98%min ----------------------------------------------------------------------------------------------

High purity Various Specifications Donepezil CAS:120014-06-4

Cas:120014-06-4

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Donepezil CAS 120014-06-4 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals in distributing t

DONEPEZIL

Cas:120014-06-4

Min.Order:1 Metric Ton

FOB Price: $10.0

Type:Trading Company

inquiry

Henan Allgreen Chemical Co.,Ltd

The company has a professional R & D team, mature technology, very competitive prices and stable high quality products for customers to order high quality and low price product efforts! Appearance:White or off-white Solid Storage:Sealed, dry, m

2-[(1-Benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one

Cas:120014-06-4

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Donepezil

Cas:120014-06-4

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Donepezine 120014-06-4 GMP Manufacturer

Cas:120014-06-4

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Donepezil

Cas:120014-06-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Donepezil Powder CAS 120014-06-4 for Alzheimer Disease

Cas:120014-06-4

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

2-[(1-Benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one 120014-06-4

Cas:120014-06-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 120014-06-4 with competitive price

Cas:120014-06-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developmen

DONEPEZIL CAS NO.120014-06-4

Cas:120014-06-4

Min.Order:1 Kilogram

FOB Price: $2.0 / 6.0

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Donepezil/ LIDE PHARMA- Factory supply / Best price

Cas:120014-06-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Product name Donepezil Appearance: White or off-white crystalline powder CAS NO. 120014-06-4 Molecular Formula C24H29NO3 Molecular Weight 379.49200 Melting point

Donepezil

Cas:120014-06-4

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

Donepezil CAS NO 120014-06-4

Cas:120014-06-4

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Donepezil 120014-06-4

Cas:120014-06-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present,

Donepezil

Cas:120014-06-4

Min.Order:1 Kilogram

FOB Price: $1200.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Donepezil CAS:120014-06-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

Donepezil CAS:120014-06-4

Cas:120014-06-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Donepezil

Cas:120014-06-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,

Donepezil CAS NO.120014-06-4

Cas:120014-06-4

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Product name:Donepezil (base) Other name:2-[(1-Benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one CAS No.:120014-06-4 Stock: Fresh Standard:In-house Purity: Not less than 99% Individual impurity: Not more than 0.5% Applica

Donepezil base

Cas:120014-06-4

Min.Order:1 Gram

FOB Price: $600.0

Type:Trading Company

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

Donepezil

Cas:120014-06-4

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

High Purity Donepezil CAS 120014-06-4 with Fast Shipment

Cas:120014-06-4

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

DONEPEZIL

Cas:120014-06-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Donepezil

Cas:120014-06-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products donepezil

Cas:120014-06-4

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Binbo Biological Co., Ltd

1.high purity 2.consistent quality 3.competitive price 4.fast shipping Binbo Biological Products Co. Ltd., is a professional high-tech enterprise which engaged in Biological products and raw materials. Binbo is engaged in R&D with perfect eq

High Quality Donepezil Powder

Cas:120014-06-4

Min.Order:1 Kilogram

FOB Price: $0.1 / 0.2

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

2-[(1-Benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one/High quality/Best price

Cas:120014-06-4

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Synthetic route

ethyl acetate thrice

ethyl acetate thrice

(±)-2-[(1-benzylpyridin-1-ium-4-yl)methyl]-5,6-dimethoxy-indan-1-one bromide

(±)-2-[(1-benzylpyridin-1-ium-4-yl)methyl]-5,6-dimethoxy-indan-1-one bromide

donepezil
120014-06-4

donepezil

Conditions
ConditionsYield
In methanol99%
donepezil hydrochloride

donepezil hydrochloride

donepezil
120014-06-4

donepezil

Conditions
ConditionsYield
With sodium hydroxide In water; ethyl acetate for 0.5h; pH=11.7; Reagent/catalyst; Solvent; pH-value;97.5%
With sodium hydrogencarbonate In water; toluene at 60 - 65℃; for 0.5h; Purification / work up;
Stage #1: donepezil hydrochloride With sodium hydrogencarbonate In water; toluene at 60 - 65℃; for 0.75h;
Stage #2: In water; isopropyl alcohol at 10 - 70℃; for 10h; Product distribution / selectivity;
2,3-dihydro-5,6-dimethoxy-2-((piperidin-4-yl)methyl)inden-1-one p-toluenesulfonic acid salt

2,3-dihydro-5,6-dimethoxy-2-((piperidin-4-yl)methyl)inden-1-one p-toluenesulfonic acid salt

benzyl bromide
100-39-0

benzyl bromide

donepezil
120014-06-4

donepezil

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide Product distribution / selectivity;96%
benzyl bromide
100-39-0

benzyl bromide

debenzyldonepezil
120014-30-4

debenzyldonepezil

donepezil
120014-06-4

donepezil

Conditions
ConditionsYield
With sodium carbonate In ethanol at 50 - 60℃; for 6h;92.3%
With triethylamine In dichloromethane for 4h; Heating / reflux;
Stage #1: benzyl bromide; debenzyldonepezil With tetrabutylammomium bromide; potassium carbonate In dichloromethane; water at 20℃;
Stage #2: With hydrogenchloride In methanol
2-(3,4-dimethoxybenzyl)-3-(N-benzyl-4-piperidine)propionic acid
259170-03-1

2-(3,4-dimethoxybenzyl)-3-(N-benzyl-4-piperidine)propionic acid

donepezil
120014-06-4

donepezil

Conditions
ConditionsYield
With trifluorormethanesulfonic acid; trifluoroacetic anhydride In dichloromethane at 24 - 28℃; Inert atmosphere; chemoselective reaction;90%
(E)-2-((1-benzylpiperidine-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one

(E)-2-((1-benzylpiperidine-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one

donepezil
120014-06-4

donepezil

Conditions
ConditionsYield
With sodium dithionite; tetrabutylammomium bromide; sodium hydrogencarbonate In water; ethyl acetate88%
With sodium dithionite; tetrabutylammomium bromide; water; sodium hydrogencarbonate In ethyl acetate at 65℃; for 0.5h; Solvent; Temperature; Time;88%
With palladium 10% on activated carbon; hydrogen In ethanol at 20℃; under 760.051 Torr; for 12h;78%
With hydrogen; palladium carbon In methanol at 20℃; under 760.051 Torr; for 2h;31 g
With hydrogen In tetrahydrofuran; water; isopropyl alcohol at 25℃; under 760.051 Torr; for 20h; Catalytic behavior; Flow reactor; chemoselective reaction;95 %Spectr.
5,6-dimethoxy-1-indanone
2107-69-9

5,6-dimethoxy-1-indanone

1-benzyl-4-formylpiperidine
22065-85-6

1-benzyl-4-formylpiperidine

donepezil
120014-06-4

donepezil

Conditions
ConditionsYield
With aluminum oxide; Pt/Al2O3 In tetrahydrofuran; ethanol; water; isopropyl alcohol at 45 - 55℃; for 7h; Temperature; Solvent; Reagent/catalyst; Aldol Condensation;88%
Multi-step reaction with 2 steps
1: sodium methylate / tetrahydrofuran
2: palladium 10% on activated carbon; hydrogenchloride / ethanol; water
View Scheme
1-benzyl-4-[(5,6-dimethoxy-1-indanol)-2-yl]methylpiperidine
120012-04-6

1-benzyl-4-[(5,6-dimethoxy-1-indanol)-2-yl]methylpiperidine

donepezil
120014-06-4

donepezil

Conditions
ConditionsYield
With tert.-butylhydroperoxide; tetrabutylammomium bromide In decane; benzene at 40℃; for 24h; Sealed tube; chemoselective reaction;85%
5,6-dimethoxy-1-indanone
2107-69-9

5,6-dimethoxy-1-indanone

1-benzyl-4-piperidinemethanol
67686-01-5

1-benzyl-4-piperidinemethanol

donepezil
120014-06-4

donepezil

Conditions
ConditionsYield
With bis(μ-chloro)-bis[1,3-di(2-pyridyl)-4,6-dimethylbenzene-N,C(2'),N-iridium chloride]; caesium carbonate In tert-Amyl alcohol for 12h; Reflux;85%
With [Ir(dpyx-N,C,N)Cl(i-Cl)]2; caesium carbonate In tert-Amyl alcohol at 130℃; for 2h; Reagent/catalyst;85%
With potassium phosphate tribasic trihydrate; C39H32Cl2N5PRu In tert-Amyl alcohol at 120℃; for 4h; Inert atmosphere; Schlenk technique;83%
1-benzyl-4-[((5,6-dimethoxy-2-ethoxycarbonylindan-1-on)-2-yl)methyl]piperidine

1-benzyl-4-[((5,6-dimethoxy-2-ethoxycarbonylindan-1-on)-2-yl)methyl]piperidine

donepezil
120014-06-4

donepezil

Conditions
ConditionsYield
With potassium hydroxide In ethanol; water for 1h; Heating / reflux;80%
With potassium hydroxide In ethanol; water for 1h; Heating / reflux;80%
C24H29NO3

C24H29NO3

donepezil
120014-06-4

donepezil

Conditions
ConditionsYield
With acetic acid; L-proline at 120℃; for 24h; Green chemistry;77%
2-((1-benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-1-oxo-2,3-dihydro-1H-indene-2-carbonitrile

2-((1-benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-1-oxo-2,3-dihydro-1H-indene-2-carbonitrile

donepezil
120014-06-4

donepezil

Conditions
ConditionsYield
With hydrogenchloride In methanol; water76.34%
2,3-dihydro-5,6-dimethoxy-2-((piperidin-4-yl)methyl)inden-1-one p-toluenesulfonic acid salt

2,3-dihydro-5,6-dimethoxy-2-((piperidin-4-yl)methyl)inden-1-one p-toluenesulfonic acid salt

benzaldehyde
100-52-7

benzaldehyde

donepezil
120014-06-4

donepezil

Conditions
ConditionsYield
Stage #1: 2,3-dihydro-5,6-dimethoxy-2-((piperidin-4-yl)methyl)inden-1-one p-toluenesulfonic acid salt With hydrogen; sodium acetate; palladium 10% on activated carbon In methanol under 760.051 Torr; for 10h;
Stage #2: benzaldehyde In methanol for 8h; Product distribution / selectivity;
62%
5-[(1-benzyl-4-piperidyl)methyl]-5-(3,4-dimethoxybenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione
848610-96-8

5-[(1-benzyl-4-piperidyl)methyl]-5-(3,4-dimethoxybenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

donepezil
120014-06-4

donepezil

Conditions
ConditionsYield
With trifluorormethanesulfonic acid In nitromethane at 100℃; for 0.5h; Friedel-Crafts acylation;61%
debenzyldonepezil
120014-30-4

debenzyldonepezil

benzyl alcohol
100-51-6

benzyl alcohol

donepezil
120014-06-4

donepezil

Conditions
ConditionsYield
With trifuran-2-yl-phosphane; C42H32F3N2O2PPd; lithium hydroxide In neat (no solvent) at 100℃; for 48h; Schlenk technique; Sealed tube; Inert atmosphere; Green chemistry; chemoselective reaction;56%
(E)-1-benzyl-4-((5,6-dimethoxy-1-oxo-1,3-dihydro-2H-inden-2-ylidene)methyl)pyridin-1-ium bromide

(E)-1-benzyl-4-((5,6-dimethoxy-1-oxo-1,3-dihydro-2H-inden-2-ylidene)methyl)pyridin-1-ium bromide

donepezil
120014-06-4

donepezil

Conditions
ConditionsYield
With platinum(IV) oxide; hydrogen In methanol at 23℃; under 760.051 Torr; for 24h; Inert atmosphere;50%
2-((1-benzoylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
120013-38-9

2-((1-benzoylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one

donepezil
120014-06-4

donepezil

Conditions
ConditionsYield
With trifluoromethylsulfonic anhydride; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate In dichloromethane at 20℃; for 2h;49%
1-benzyl-4-<(5,6-dimethoxy-1-oxoindan-2-ylidenyl)methyl>piperidine
120014-07-5

1-benzyl-4-<(5,6-dimethoxy-1-oxoindan-2-ylidenyl)methyl>piperidine

donepezil
120014-06-4

donepezil

Conditions
ConditionsYield
With hydrogen; palladium 10% on activated carbon In tetrahydrofuran at 20℃; for 16h;37%
With hydrogen; palladium 10% on activated carbon In tetrahydrofuran at 20℃; under 760.051 Torr; for 6h;
With hydrogen; nickel In tetrahydrofuran at 8 - 38℃; under 750.075 - 9000.9 Torr; for 0.666667 - 6h; Product distribution / selectivity;
1-benzyl-4-<(5,6-dimethoxy-1-oxoindan-2-ylidenyl)methyl>piperidine hydrochloride

1-benzyl-4-<(5,6-dimethoxy-1-oxoindan-2-ylidenyl)methyl>piperidine hydrochloride

donepezil
120014-06-4

donepezil

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In tetrahydrofuran under 760 Torr; for 6h; Ambient temperature;
Stage #1: 1-benzyl-4-<(5,6-dimethoxy-1-oxoindan-2-ylidenyl)methyl>piperidine hydrochloride In methanol; acetic acid at 25 - 45℃;
Stage #2: With hydrogen; 5%-palladium/activated carbon In methanol; acetic acid under 1103.36 - 1471.14 Torr;
With hydrogen; palladium 10% on activated carbon In tetrahydrofuran at 20℃; for 6h;
Stage #1: 1-benzyl-4-<(5,6-dimethoxy-1-oxoindan-2-ylidenyl)methyl>piperidine hydrochloride With hydrogen; acetic acid; 5% Pd(II)/C(eggshell) In methanol at 28 - 33℃; under 1103.36 - 1471.14 Torr;
Stage #2: With sodium carbonate In dichloromethane; water for 7 - 8h;
Stage #3: With hydrogenchloride In isopropyl alcohol at 25 - 30℃; pH=2;
benzyl bromide
100-39-0

benzyl bromide

debenzyldonepezil
120014-30-4

debenzyldonepezil

A

1,1-dibenzyl-4-(5,6-dimethoxy-1-oxo-indan-2-ylmethyl)-piperidinium; bromide

1,1-dibenzyl-4-(5,6-dimethoxy-1-oxo-indan-2-ylmethyl)-piperidinium; bromide

B

donepezil
120014-06-4

donepezil

Conditions
ConditionsYield
With sodium carbonate In methanol; isopropyl alcohol at 60 - 65℃; for 11h;
5,6-dimethoxy-1-indanone
2107-69-9

5,6-dimethoxy-1-indanone

donepezil
120014-06-4

donepezil

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium carbonate / methanol; H2O / Heating
1.2: 77 percent / methanol; H2O / 2.5 h / 75 °C
2.1: 31 g / H2 / palladium carbon / methanol / 2 h / 20 °C / 760.05 Torr
View Scheme
Multi-step reaction with 3 steps
1: 95.6 percent / p-toluenesulfonic acid / toluene / 6 h / Heating
2: 90 percent / hydrogen; acetic acid / palladium on activated charcoal / methanol / 7 h / 60 - 65 °C
3: sodium carbonate / methanol; propan-2-ol / 11 h / 60 - 65 °C
View Scheme
Multi-step reaction with 2 steps
1: tetrabutylammomium bromide; potassium hydroxide / water; dichloromethane / 1.5 h / 38 °C
2: tetrabutylammomium bromide; sodium hydrogencarbonate; sodium dithionite / water; ethyl acetate
View Scheme
Multi-step reaction with 2 steps
1: tetrabutylammomium bromide; potassium hydroxide / dichloromethane; water / 1.5 h / 38 °C
2: tetrabutylammomium bromide; sodium hydrogencarbonate; sodium dithionite; water / ethyl acetate / 0.5 h / 65 °C
View Scheme
Multi-step reaction with 3 steps
1: toluene-4-sulfonic acid / toluene / 24 h / Reflux
2: hydrogen / neat (no solvent) / 144 h / 50 °C / 760.05 Torr
3: sodium carbonate / isopropyl alcohol / 12 h / 50 °C
View Scheme
1-benzyl-4-formylpiperidine
22065-85-6

1-benzyl-4-formylpiperidine

donepezil
120014-06-4

donepezil

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium carbonate / methanol; H2O / Heating
1.2: 77 percent / methanol; H2O / 2.5 h / 75 °C
2.1: 31 g / H2 / palladium carbon / methanol / 2 h / 20 °C / 760.05 Torr
View Scheme
Multi-step reaction with 3 steps
1.1: piperidinium acetate / ethanol / 0.5 h
1.2: 47 percent / NaBH3CN / ethanol / 0 - 20 °C
2.1: 44 percent / K2CO3 / dimethylformamide
3.1: 61 percent / TfOH / nitromethane / 0.5 h / 100 °C
View Scheme
Multi-step reaction with 2 steps
1: tetrabutylammomium bromide; potassium hydroxide / water; dichloromethane / 1.5 h / 38 °C
2: tetrabutylammomium bromide; sodium hydrogencarbonate; sodium dithionite / water; ethyl acetate
View Scheme
pyridine-4-carbaldehyde
872-85-5

pyridine-4-carbaldehyde

N6-protected N2-Fmoc-lysine on Wang resin

N6-protected N2-Fmoc-lysine on Wang resin

donepezil
120014-06-4

donepezil

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 95.6 percent / p-toluenesulfonic acid / toluene / 6 h / Heating
2: 90 percent / hydrogen; acetic acid / palladium on activated charcoal / methanol / 7 h / 60 - 65 °C
3: sodium carbonate / methanol; propan-2-ol / 11 h / 60 - 65 °C
View Scheme
(E)-5, 6-dimethoxy-2-(pyridin-4-ylmethylene)-2, 3-dihydro-1H-inden-1-one
877606-65-0

(E)-5, 6-dimethoxy-2-(pyridin-4-ylmethylene)-2, 3-dihydro-1H-inden-1-one

donepezil
120014-06-4

donepezil

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 90 percent / hydrogen; acetic acid / palladium on activated charcoal / methanol / 7 h / 60 - 65 °C
2: sodium carbonate / methanol; propan-2-ol / 11 h / 60 - 65 °C
View Scheme
Multi-step reaction with 2 steps
1: acetonitrile / 24 h / Reflux
2: platinum(IV) oxide; hydrogen / methanol / 24 h / 23 °C / 760.05 Torr / Inert atmosphere
View Scheme
5-(1-benzyl-piperidin-4-ylmethyl)-2,2-dimethyl-[1,3]dioxane-4,6-dione
865718-00-9

5-(1-benzyl-piperidin-4-ylmethyl)-2,2-dimethyl-[1,3]dioxane-4,6-dione

donepezil
120014-06-4

donepezil

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 44 percent / K2CO3 / dimethylformamide
2: 61 percent / TfOH / nitromethane / 0.5 h / 100 °C
View Scheme
benzyl bromide
100-39-0

benzyl bromide

5,6-dimethoxy-2-(piperidine-4-ylmethyl)-2,3-dihydro-1H-inden-1-one hydrochloride

5,6-dimethoxy-2-(piperidine-4-ylmethyl)-2,3-dihydro-1H-inden-1-one hydrochloride

donepezil
120014-06-4

donepezil

Conditions
ConditionsYield
With tetrabutylammomium bromide; potassium carbonate In dichloromethane; water at 20 - 25℃; for 1h;
Stage #1: benzyl bromide; 5,6-dimethoxy-2-(piperidine-4-ylmethyl)-2,3-dihydro-1H-inden-1-one hydrochloride With monopotassium carbonate; tetrabutylammomium bromide In methylene chlorid; water at 20 - 25℃; for 1h;
Stage #2: With hydrogenchloride In dichloromethane; water at 20 - 25℃; for 0.25h;
Stage #3: With ammonia In water; ethyl acetate pH=9.5;
1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-ylidenyl]methylpiperidine maleate

1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-ylidenyl]methylpiperidine maleate

donepezil
120014-06-4

donepezil

Conditions
ConditionsYield
With sodium hydroxide In water; toluene at 20 - 40℃; for 2h;
benzyl chloride
100-44-7

benzyl chloride

debenzyldonepezil
120014-30-4

debenzyldonepezil

donepezil
120014-06-4

donepezil

Conditions
ConditionsYield
With potassium carbonate; tetra-(n-butyl)ammonium iodide In acetone at 60℃;
With potassium carbonate; polyethylene glycol In water; ethyl acetate at 45℃;
With potassium carbonate In water; ethyl acetate at 50 - 55℃; for 14h; Inert atmosphere;
With sodium hydrogencarbonate In ethanol at 65℃; for 0.5h; Temperature;
benzaldehyde
100-52-7

benzaldehyde

donepezil
120014-06-4

donepezil

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: hydrogen; platinum on activated charcoal / toluene / 80 °C / Flow reactor
2: diisobutylaluminium hydride / toluene; hexane / 2.5 h / -78 °C / Flow reactor
3: water / isopropyl alcohol; tetrahydrofuran / 3 h / 55 °C / Flow reactor
4: hydrogen / isopropyl alcohol; water; tetrahydrofuran / 20 h / 25 °C / 760.05 Torr / Flow reactor
View Scheme
donepezil
120014-06-4

donepezil

C24H24(2)H5NO3

C24H24(2)H5NO3

Conditions
ConditionsYield
With [(2)H6]acetone; tris(pentafluorophenyl)borate In toluene at 150℃; for 3h; Inert atmosphere;98%
donepezil
120014-06-4

donepezil

debenzyldonepezil
120014-30-4

debenzyldonepezil

Conditions
ConditionsYield
With ammonium formate; palladium 10% on activated carbon In methanol at 20℃; for 3h; Heating / reflux;97%
With hydrogen In methanol at 20℃; under 760.051 Torr; for 72h;
donepezil
120014-06-4

donepezil

donepezil hydrochloride

donepezil hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethanol96.2%
With hydrogenchloride In ethanol96.5%
With hydrogenchloride In ethanol96.4%
donepezil
120014-06-4

donepezil

donepezil-d1
1228545-52-5

donepezil-d1

Conditions
ConditionsYield
With tris(pentafluorophenyl)borate; water-d2 In tetrahydrofuran at 100℃; for 12h; Solvent; Inert atmosphere; regioselective reaction;96%
With sodium methylate at 20℃; Reagent/catalyst;50%
(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

donepezil
120014-06-4

donepezil

1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine fumarate

1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine fumarate

Conditions
ConditionsYield
In ethanol at 20 - 60℃; for 2h;95.4%
In ethanol; ethyl acetate at 20℃; Product distribution / selectivity;
In methanol at 25 - 30℃; for 5h;5.1 g
In ethanol; water at 20 - 60℃; Sealed tube;
chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

donepezil
120014-06-4

donepezil

4-[(5,6-dimethoxy-1-indanon)-2-yl]methyl-1-ethoxycarbonylpiperidine
120013-42-5

4-[(5,6-dimethoxy-1-indanon)-2-yl]methyl-1-ethoxycarbonylpiperidine

Conditions
ConditionsYield
With sodium hydrogencarbonate In benzene94%
donepezil
120014-06-4

donepezil

Donepezil sulphate
881405-91-0

Donepezil sulphate

Conditions
ConditionsYield
With sulfuric acid In isopropyl alcohol at 0℃; for 2h;92.4%
With sulfuric acid In ethanol; ethyl acetate at 20℃; Product distribution / selectivity;
maleic acid
110-16-7

maleic acid

donepezil
120014-06-4

donepezil

1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-ylidenyl]methylpiperidine maleate

1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-ylidenyl]methylpiperidine maleate

Conditions
ConditionsYield
In isopropyl alcohol at 20 - 60℃; for 1h;91.2%
In water; toluene at 25 - 30℃;90%
In ethanol; ethyl acetate at 20℃; Product distribution / selectivity;
In methanol; water at 20 - 100℃; Sealed tube;
donepezil
120014-06-4

donepezil

1-benzyl-4-(5,6-dimethoxy-1-indanon-2-yl)methylpiperidine hydrobromide

1-benzyl-4-(5,6-dimethoxy-1-indanon-2-yl)methylpiperidine hydrobromide

Conditions
ConditionsYield
With hydrogen bromide In isopropyl alcohol89.9%
With hydrogen bromide In ethanol; water at 10 - 35℃; for 12.33h;58.9%
With hydrogen bromide In methanol; water Purification / work up;
With hydrogen bromide In methanol; water at 0 - 5℃; for 2 - 3h;
methanesulfonic acid
75-75-2

methanesulfonic acid

donepezil
120014-06-4

donepezil

donepezil methanesulfonate

donepezil methanesulfonate

Conditions
ConditionsYield
In isopropyl alcohol at 20℃; Heating / reflux;89.2%
In ethanol; ethyl acetate at 20℃; Product distribution / selectivity;
In ethanol; ethyl acetate at 20℃; Product distribution / selectivity;
In isopropyl alcohol for 168h;
donepezil
120014-06-4

donepezil

benzenesulfonic acid
98-11-3

benzenesulfonic acid

donepezil benzenenesulfonate

donepezil benzenenesulfonate

Conditions
ConditionsYield
In isopropyl alcohol at 20℃; Heating / reflux;87.5%
In ethanol; ethyl acetate Product distribution / selectivity;
In ethanol; ethyl acetate Product distribution / selectivity;
In isopropyl alcohol for 168h;
In ethanol; water at 20 - 80℃; Sealed tube;
toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

donepezil
120014-06-4

donepezil

1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine p-toluenesulphonate

1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine p-toluenesulphonate

Conditions
ConditionsYield
In isopropyl alcohol at 20℃; Heating / reflux;84.2%
In ethanol; ethyl acetate at 20℃; Product distribution / selectivity;
In ethanol; ethyl acetate at 20℃; Product distribution / selectivity;
In ethyl acetate; acetone at 25 - 30℃; for 12h;6.5 g
In isopropyl alcohol for 168h;
donepezil
120014-06-4

donepezil

2-(1-bromodifluoromethyl)benzo-1,3-oxazole
186828-50-2

2-(1-bromodifluoromethyl)benzo-1,3-oxazole

C32H32F2N2O4

C32H32F2N2O4

Conditions
ConditionsYield
With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; zinc(II) chloride; lithium diisopropyl amide at -10℃; for 12h;83%
n-heptanoic anhydride
626-27-7

n-heptanoic anhydride

donepezil
120014-06-4

donepezil

donepezil enanthate

donepezil enanthate

Conditions
ConditionsYield
Stage #1: n-heptanoic anhydride; donepezil With lithium hexamethyldisilazane In tetrahydrofuran at -78 - 10℃; Inert atmosphere;
Stage #2: In tetrahydrofuran at -78 - 30℃;
81.7%
i-Pr2O

i-Pr2O

N-benzyl-2-(3,4-dimethoxybenzyl)-3-(4-piperidine)propionic acid

N-benzyl-2-(3,4-dimethoxybenzyl)-3-(4-piperidine)propionic acid

donepezil
120014-06-4

donepezil

donepezil hydrochloride

donepezil hydrochloride

Conditions
ConditionsYield
With P2O5; MeSO3H In methanol; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; dichloromethane80%
Ethyl bromodifluoroacetate
667-27-6

Ethyl bromodifluoroacetate

donepezil
120014-06-4

donepezil

ethyl 2-(2-((1-benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)-2,2-difluoroacetate

ethyl 2-(2-((1-benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)-2,2-difluoroacetate

Conditions
ConditionsYield
With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; zinc(II) chloride; lithium diisopropyl amide at -10℃; for 12h;80%
palmitic anhydride
623-65-4

palmitic anhydride

donepezil
120014-06-4

donepezil

2-((1-benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-1H-inden-3-ylpalmitate

2-((1-benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-1H-inden-3-ylpalmitate

Conditions
ConditionsYield
Stage #1: palmitic anhydride; donepezil With lithium hexamethyldisilazane In tetrahydrofuran at -78 - 10℃; Inert atmosphere;
Stage #2: In tetrahydrofuran at -78 - 30℃;
79.5%
donepezil
120014-06-4

donepezil

2-((1-benzylpiperidin-4-yl)methyl)-2-bromo-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one

2-((1-benzylpiperidin-4-yl)methyl)-2-bromo-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one

Conditions
ConditionsYield
With hydrogen bromide; dimethyl sulfoxide In water; ethyl acetate at 60℃;78%

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