Donepezil supplier | CasNO.120014-06-4

Name
2-[(1-Benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one
EINECS 601-651-9
CAS No. 120014-06-4
Article Data68
CAS DataBase
Density 1.141 g/cm³
Solubility 2.931 mg/L in water
Melting Point 207 ºC
Formula C₂₄H₂₉NO₃
Boiling Point 527.9 ºC at 760 mmHg
Molecular Weight 379.499
Flash Point 273.1 ºC
Transport Information
Appearance white or almost white crystal powder
Safety 26-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine;Donepezil base;
PSA 38.77000
LogP 4.29900

Synthetic route

ethyl acetate thrice: ethyl acetate thrice

: (±)-2-[(1-benzylpyridin-1-ium-4-yl)methyl]-5,6-dimethoxy-indan-1-one bromide

: 120014-06-4
donepezil

Conditions

Conditions	Yield
In methanol	99%

: donepezil hydrochloride

: 120014-06-4
donepezil

Conditions

Conditions	Yield
With sodium hydroxide In water; ethyl acetate for 0.5h; pH=11.7; Reagent/catalyst; Solvent; pH-value;	97.5%
With sodium hydrogencarbonate In water; toluene at 60 - 65℃; for 0.5h; Purification / work up;
Stage #1: donepezil hydrochloride With sodium hydrogencarbonate In water; toluene at 60 - 65℃; for 0.75h; Stage #2: In water; isopropyl alcohol at 10 - 70℃; for 10h; Product distribution / selectivity;

: 2,3-dihydro-5,6-dimethoxy-2-((piperidin-4-yl)methyl)inden-1-one p-toluenesulfonic acid salt

: 100-39-0
benzyl bromide

: 120014-06-4
donepezil

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide Product distribution / selectivity;	96%

: 100-39-0
benzyl bromide

: 120014-30-4
debenzyldonepezil

: 120014-06-4
donepezil

Conditions

Conditions	Yield
With sodium carbonate In ethanol at 50 - 60℃; for 6h;	92.3%
With triethylamine In dichloromethane for 4h; Heating / reflux;
Stage #1: benzyl bromide; debenzyldonepezil With tetrabutylammomium bromide; potassium carbonate In dichloromethane; water at 20℃; Stage #2: With hydrogenchloride In methanol

: 259170-03-1
2-(3,4-dimethoxybenzyl)-3-(N-benzyl-4-piperidine)propionic acid

: 120014-06-4
donepezil

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid; trifluoroacetic anhydride In dichloromethane at 24 - 28℃; Inert atmosphere; chemoselective reaction;	90%

: (E)-2-((1-benzylpiperidine-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one

: 120014-06-4
donepezil

Conditions

Conditions	Yield
With sodium dithionite; tetrabutylammomium bromide; sodium hydrogencarbonate In water; ethyl acetate	88%
With sodium dithionite; tetrabutylammomium bromide; water; sodium hydrogencarbonate In ethyl acetate at 65℃; for 0.5h; Solvent; Temperature; Time;	88%
With palladium 10% on activated carbon; hydrogen In ethanol at 20℃; under 760.051 Torr; for 12h;	78%
With hydrogen; palladium carbon In methanol at 20℃; under 760.051 Torr; for 2h;	31 g
With hydrogen In tetrahydrofuran; water; isopropyl alcohol at 25℃; under 760.051 Torr; for 20h; Catalytic behavior; Flow reactor; chemoselective reaction;	95 %Spectr.

: 2107-69-9
5,6-dimethoxy-1-indanone

: 22065-85-6
1-benzyl-4-formylpiperidine

: 120014-06-4
donepezil

Conditions

Conditions	Yield
With aluminum oxide; Pt/Al2O3 In tetrahydrofuran; ethanol; water; isopropyl alcohol at 45 - 55℃; for 7h; Temperature; Solvent; Reagent/catalyst; Aldol Condensation;	88%
Multi-step reaction with 2 steps 1: sodium methylate / tetrahydrofuran 2: palladium 10% on activated carbon; hydrogenchloride / ethanol; water View Scheme

: 120012-04-6
1-benzyl-4-[(5,6-dimethoxy-1-indanol)-2-yl]methylpiperidine

: 120014-06-4
donepezil

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; tetrabutylammomium bromide In decane; benzene at 40℃; for 24h; Sealed tube; chemoselective reaction;	85%

: 2107-69-9
5,6-dimethoxy-1-indanone

: 67686-01-5
1-benzyl-4-piperidinemethanol

: 120014-06-4
donepezil

Conditions

Conditions	Yield
With bis(μ-chloro)-bis[1,3-di(2-pyridyl)-4,6-dimethylbenzene-N,C(2'),N-iridium chloride]; caesium carbonate In tert-Amyl alcohol for 12h; Reflux;	85%
With [Ir(dpyx-N,C,N)Cl(i-Cl)]2; caesium carbonate In tert-Amyl alcohol at 130℃; for 2h; Reagent/catalyst;	85%
With potassium phosphate tribasic trihydrate; C39H32Cl2N5PRu In tert-Amyl alcohol at 120℃; for 4h; Inert atmosphere; Schlenk technique;	83%

: 1-benzyl-4-[((5,6-dimethoxy-2-ethoxycarbonylindan-1-on)-2-yl)methyl]piperidine

: 120014-06-4
donepezil

Conditions

Conditions	Yield
With potassium hydroxide In ethanol; water for 1h; Heating / reflux;	80%
With potassium hydroxide In ethanol; water for 1h; Heating / reflux;	80%

: C24H29NO3

: 120014-06-4
donepezil

Conditions

Conditions	Yield
With acetic acid; L-proline at 120℃; for 24h; Green chemistry;	77%

: 2-((1-benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-1-oxo-2,3-dihydro-1H-indene-2-carbonitrile

: 120014-06-4
donepezil

Conditions

Conditions	Yield
With hydrogenchloride In methanol; water	76.34%

: 2,3-dihydro-5,6-dimethoxy-2-((piperidin-4-yl)methyl)inden-1-one p-toluenesulfonic acid salt

: 100-52-7
benzaldehyde

: 120014-06-4
donepezil

Conditions

Conditions	Yield
Stage #1: 2,3-dihydro-5,6-dimethoxy-2-((piperidin-4-yl)methyl)inden-1-one p-toluenesulfonic acid salt With hydrogen; sodium acetate; palladium 10% on activated carbon In methanol under 760.051 Torr; for 10h; Stage #2: benzaldehyde In methanol for 8h; Product distribution / selectivity;	62%

: 848610-96-8
5-[(1-benzyl-4-piperidyl)methyl]-5-(3,4-dimethoxybenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

: 120014-06-4
donepezil

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid In nitromethane at 100℃; for 0.5h; Friedel-Crafts acylation;	61%

: 120014-30-4
debenzyldonepezil

: 100-51-6
benzyl alcohol

: 120014-06-4
donepezil

Conditions

Conditions	Yield
With trifuran-2-yl-phosphane; C42H32F3N2O2PPd; lithium hydroxide In neat (no solvent) at 100℃; for 48h; Schlenk technique; Sealed tube; Inert atmosphere; Green chemistry; chemoselective reaction;	56%

: (E)-1-benzyl-4-((5,6-dimethoxy-1-oxo-1,3-dihydro-2H-inden-2-ylidene)methyl)pyridin-1-ium bromide

: 120014-06-4
donepezil

Conditions

Conditions	Yield
With platinum(IV) oxide; hydrogen In methanol at 23℃; under 760.051 Torr; for 24h; Inert atmosphere;	50%

: 120013-38-9
2-((1-benzoylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one

: 120014-06-4
donepezil

Conditions

Conditions	Yield
With trifluoromethylsulfonic anhydride; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate In dichloromethane at 20℃; for 2h;	49%

: 120014-07-5
1-benzyl-4-<(5,6-dimethoxy-1-oxoindan-2-ylidenyl)methyl>piperidine

: 120014-06-4
donepezil

Conditions

Conditions	Yield
With hydrogen; palladium 10% on activated carbon In tetrahydrofuran at 20℃; for 16h;	37%
With hydrogen; palladium 10% on activated carbon In tetrahydrofuran at 20℃; under 760.051 Torr; for 6h;
With hydrogen; nickel In tetrahydrofuran at 8 - 38℃; under 750.075 - 9000.9 Torr; for 0.666667 - 6h; Product distribution / selectivity;

: 1-benzyl-4-<(5,6-dimethoxy-1-oxoindan-2-ylidenyl)methyl>piperidine hydrochloride

: 120014-06-4
donepezil

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In tetrahydrofuran under 760 Torr; for 6h; Ambient temperature;
Stage #1: 1-benzyl-4-<(5,6-dimethoxy-1-oxoindan-2-ylidenyl)methyl>piperidine hydrochloride In methanol; acetic acid at 25 - 45℃; Stage #2: With hydrogen; 5%-palladium/activated carbon In methanol; acetic acid under 1103.36 - 1471.14 Torr;
With hydrogen; palladium 10% on activated carbon In tetrahydrofuran at 20℃; for 6h;
Stage #1: 1-benzyl-4-<(5,6-dimethoxy-1-oxoindan-2-ylidenyl)methyl>piperidine hydrochloride With hydrogen; acetic acid; 5% Pd(II)/C(eggshell) In methanol at 28 - 33℃; under 1103.36 - 1471.14 Torr; Stage #2: With sodium carbonate In dichloromethane; water for 7 - 8h; Stage #3: With hydrogenchloride In isopropyl alcohol at 25 - 30℃; pH=2;

: 100-39-0
benzyl bromide

: 120014-30-4
debenzyldonepezil

A: 1,1-dibenzyl-4-(5,6-dimethoxy-1-oxo-indan-2-ylmethyl)-piperidinium; bromide

B: 120014-06-4
donepezil

Conditions

Conditions	Yield
With sodium carbonate In methanol; isopropyl alcohol at 60 - 65℃; for 11h;

...Expand

: 2107-69-9
5,6-dimethoxy-1-indanone

: 120014-06-4
donepezil

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: potassium carbonate / methanol; H2O / Heating 1.2: 77 percent / methanol; H2O / 2.5 h / 75 °C 2.1: 31 g / H2 / palladium carbon / methanol / 2 h / 20 °C / 760.05 Torr View Scheme
Multi-step reaction with 3 steps 1: 95.6 percent / p-toluenesulfonic acid / toluene / 6 h / Heating 2: 90 percent / hydrogen; acetic acid / palladium on activated charcoal / methanol / 7 h / 60 - 65 °C 3: sodium carbonate / methanol; propan-2-ol / 11 h / 60 - 65 °C View Scheme
Multi-step reaction with 2 steps 1: tetrabutylammomium bromide; potassium hydroxide / water; dichloromethane / 1.5 h / 38 °C 2: tetrabutylammomium bromide; sodium hydrogencarbonate; sodium dithionite / water; ethyl acetate View Scheme
Multi-step reaction with 2 steps 1: tetrabutylammomium bromide; potassium hydroxide / dichloromethane; water / 1.5 h / 38 °C 2: tetrabutylammomium bromide; sodium hydrogencarbonate; sodium dithionite; water / ethyl acetate / 0.5 h / 65 °C View Scheme
Multi-step reaction with 3 steps 1: toluene-4-sulfonic acid / toluene / 24 h / Reflux 2: hydrogen / neat (no solvent) / 144 h / 50 °C / 760.05 Torr 3: sodium carbonate / isopropyl alcohol / 12 h / 50 °C View Scheme

: 22065-85-6
1-benzyl-4-formylpiperidine

: 120014-06-4
donepezil

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: potassium carbonate / methanol; H2O / Heating 1.2: 77 percent / methanol; H2O / 2.5 h / 75 °C 2.1: 31 g / H2 / palladium carbon / methanol / 2 h / 20 °C / 760.05 Torr View Scheme
Multi-step reaction with 3 steps 1.1: piperidinium acetate / ethanol / 0.5 h 1.2: 47 percent / NaBH3CN / ethanol / 0 - 20 °C 2.1: 44 percent / K2CO3 / dimethylformamide 3.1: 61 percent / TfOH / nitromethane / 0.5 h / 100 °C View Scheme
Multi-step reaction with 2 steps 1: tetrabutylammomium bromide; potassium hydroxide / water; dichloromethane / 1.5 h / 38 °C 2: tetrabutylammomium bromide; sodium hydrogencarbonate; sodium dithionite / water; ethyl acetate View Scheme

: 872-85-5
pyridine-4-carbaldehyde

N6-protected N2-Fmoc-lysine on Wang resin: N6-protected N2-Fmoc-lysine on Wang resin

: 120014-06-4
donepezil

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 95.6 percent / p-toluenesulfonic acid / toluene / 6 h / Heating 2: 90 percent / hydrogen; acetic acid / palladium on activated charcoal / methanol / 7 h / 60 - 65 °C 3: sodium carbonate / methanol; propan-2-ol / 11 h / 60 - 65 °C View Scheme

: 877606-65-0
(E)-5, 6-dimethoxy-2-(pyridin-4-ylmethylene)-2, 3-dihydro-1H-inden-1-one

: 120014-06-4
donepezil

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 90 percent / hydrogen; acetic acid / palladium on activated charcoal / methanol / 7 h / 60 - 65 °C 2: sodium carbonate / methanol; propan-2-ol / 11 h / 60 - 65 °C View Scheme
Multi-step reaction with 2 steps 1: acetonitrile / 24 h / Reflux 2: platinum(IV) oxide; hydrogen / methanol / 24 h / 23 °C / 760.05 Torr / Inert atmosphere View Scheme

: 865718-00-9
5-(1-benzyl-piperidin-4-ylmethyl)-2,2-dimethyl-[1,3]dioxane-4,6-dione

: 120014-06-4
donepezil

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 44 percent / K2CO3 / dimethylformamide 2: 61 percent / TfOH / nitromethane / 0.5 h / 100 °C View Scheme

: 100-39-0
benzyl bromide

: 5,6-dimethoxy-2-(piperidine-4-ylmethyl)-2,3-dihydro-1H-inden-1-one hydrochloride

: 120014-06-4
donepezil

Conditions

Conditions	Yield
With tetrabutylammomium bromide; potassium carbonate In dichloromethane; water at 20 - 25℃; for 1h;
Stage #1: benzyl bromide; 5,6-dimethoxy-2-(piperidine-4-ylmethyl)-2,3-dihydro-1H-inden-1-one hydrochloride With monopotassium carbonate; tetrabutylammomium bromide In methylene chlorid; water at 20 - 25℃; for 1h; Stage #2: With hydrogenchloride In dichloromethane; water at 20 - 25℃; for 0.25h; Stage #3: With ammonia In water; ethyl acetate pH=9.5;

: 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-ylidenyl]methylpiperidine maleate

: 120014-06-4
donepezil

Conditions

Conditions	Yield
With sodium hydroxide In water; toluene at 20 - 40℃; for 2h;

: 100-44-7
benzyl chloride

: 120014-30-4
debenzyldonepezil

: 120014-06-4
donepezil

Conditions

Conditions	Yield
With potassium carbonate; tetra-(n-butyl)ammonium iodide In acetone at 60℃;
With potassium carbonate; polyethylene glycol In water; ethyl acetate at 45℃;
With potassium carbonate In water; ethyl acetate at 50 - 55℃; for 14h; Inert atmosphere;
With sodium hydrogencarbonate In ethanol at 65℃; for 0.5h; Temperature;

: 100-52-7
benzaldehyde

: 120014-06-4
donepezil

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: hydrogen; platinum on activated charcoal / toluene / 80 °C / Flow reactor 2: diisobutylaluminium hydride / toluene; hexane / 2.5 h / -78 °C / Flow reactor 3: water / isopropyl alcohol; tetrahydrofuran / 3 h / 55 °C / Flow reactor 4: hydrogen / isopropyl alcohol; water; tetrahydrofuran / 20 h / 25 °C / 760.05 Torr / Flow reactor View Scheme

: 120014-06-4
donepezil

: C24H24(2)H5NO3

Conditions

Conditions	Yield
With [(2)H6]acetone; tris(pentafluorophenyl)borate In toluene at 150℃; for 3h; Inert atmosphere;	98%

: 120014-06-4
donepezil

: 120014-30-4
debenzyldonepezil

Conditions

Conditions	Yield
With ammonium formate; palladium 10% on activated carbon In methanol at 20℃; for 3h; Heating / reflux;	97%
With hydrogen In methanol at 20℃; under 760.051 Torr; for 72h;

: 120014-06-4
donepezil

: donepezil hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol	96.2%
With hydrogenchloride In ethanol	96.5%
With hydrogenchloride In ethanol	96.4%

: 120014-06-4
donepezil

: 1228545-52-5
donepezil-d1

Conditions

Conditions	Yield
With tris(pentafluorophenyl)borate; water-d2 In tetrahydrofuran at 100℃; for 12h; Solvent; Inert atmosphere; regioselective reaction;	96%
With sodium methylate at 20℃; Reagent/catalyst;	50%

: 110-17-8
(2E)-but-2-enedioic acid

: 120014-06-4
donepezil

: 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine fumarate

Conditions

Conditions	Yield
In ethanol at 20 - 60℃; for 2h;	95.4%
In ethanol; ethyl acetate at 20℃; Product distribution / selectivity;
In methanol at 25 - 30℃; for 5h;	5.1 g
In ethanol; water at 20 - 60℃; Sealed tube;

: 541-41-3
chloroformic acid ethyl ester

: 120014-06-4
donepezil

: 120013-42-5
4-[(5,6-dimethoxy-1-indanon)-2-yl]methyl-1-ethoxycarbonylpiperidine

Conditions

Conditions	Yield
With sodium hydrogencarbonate In benzene	94%

: 120014-06-4
donepezil

: 881405-91-0
Donepezil sulphate

Conditions

Conditions	Yield
With sulfuric acid In isopropyl alcohol at 0℃; for 2h;	92.4%
With sulfuric acid In ethanol; ethyl acetate at 20℃; Product distribution / selectivity;

: 110-16-7
maleic acid

: 120014-06-4
donepezil

: 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-ylidenyl]methylpiperidine maleate

Conditions

Conditions	Yield
In isopropyl alcohol at 20 - 60℃; for 1h;	91.2%
In water; toluene at 25 - 30℃;	90%
In ethanol; ethyl acetate at 20℃; Product distribution / selectivity;
In methanol; water at 20 - 100℃; Sealed tube;

: 120014-06-4
donepezil

: 1-benzyl-4-(5,6-dimethoxy-1-indanon-2-yl)methylpiperidine hydrobromide

Conditions

Conditions	Yield
With hydrogen bromide In isopropyl alcohol	89.9%
With hydrogen bromide In ethanol; water at 10 - 35℃; for 12.33h;	58.9%
With hydrogen bromide In methanol; water Purification / work up;
With hydrogen bromide In methanol; water at 0 - 5℃; for 2 - 3h;

: 75-75-2
methanesulfonic acid

: 120014-06-4
donepezil

: donepezil methanesulfonate

Conditions

Conditions	Yield
In isopropyl alcohol at 20℃; Heating / reflux;	89.2%
In ethanol; ethyl acetate at 20℃; Product distribution / selectivity;
In ethanol; ethyl acetate at 20℃; Product distribution / selectivity;
In isopropyl alcohol for 168h;

: 120014-06-4
donepezil

: 98-11-3
benzenesulfonic acid

: donepezil benzenenesulfonate

Conditions

Conditions	Yield
In isopropyl alcohol at 20℃; Heating / reflux;	87.5%
In ethanol; ethyl acetate Product distribution / selectivity;
In ethanol; ethyl acetate Product distribution / selectivity;
In isopropyl alcohol for 168h;
In ethanol; water at 20 - 80℃; Sealed tube;

: 104-15-4
toluene-4-sulfonic acid

: 120014-06-4
donepezil

: 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine p-toluenesulphonate

Conditions

Conditions	Yield
In isopropyl alcohol at 20℃; Heating / reflux;	84.2%
In ethanol; ethyl acetate at 20℃; Product distribution / selectivity;
In ethanol; ethyl acetate at 20℃; Product distribution / selectivity;
In ethyl acetate; acetone at 25 - 30℃; for 12h;	6.5 g
In isopropyl alcohol for 168h;

: 120014-06-4
donepezil

: 186828-50-2
2-(1-bromodifluoromethyl)benzo-1,3-oxazole

: C32H32F2N2O4

Conditions

Conditions	Yield
With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; zinc(II) chloride; lithium diisopropyl amide at -10℃; for 12h;	83%

: 626-27-7
n-heptanoic anhydride

: 120014-06-4
donepezil

: donepezil enanthate

Conditions

Conditions	Yield
Stage #1: n-heptanoic anhydride; donepezil With lithium hexamethyldisilazane In tetrahydrofuran at -78 - 10℃; Inert atmosphere; Stage #2: In tetrahydrofuran at -78 - 30℃;	81.7%

i-Pr2O: i-Pr2O

N-benzyl-2-(3,4-dimethoxybenzyl)-3-(4-piperidine)propionic acid: N-benzyl-2-(3,4-dimethoxybenzyl)-3-(4-piperidine)propionic acid

: 120014-06-4
donepezil

: donepezil hydrochloride

Conditions

Conditions	Yield
With P2O5; MeSO3H In methanol; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; dichloromethane	80%

...Expand

: 667-27-6
Ethyl bromodifluoroacetate

: 120014-06-4
donepezil

: ethyl 2-(2-((1-benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)-2,2-difluoroacetate

Conditions

Conditions	Yield
With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; zinc(II) chloride; lithium diisopropyl amide at -10℃; for 12h;	80%

: 623-65-4
palmitic anhydride

: 120014-06-4
donepezil

: 2-((1-benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-1H-inden-3-ylpalmitate

Conditions

Conditions	Yield
Stage #1: palmitic anhydride; donepezil With lithium hexamethyldisilazane In tetrahydrofuran at -78 - 10℃; Inert atmosphere; Stage #2: In tetrahydrofuran at -78 - 30℃;	79.5%

: 120014-06-4
donepezil

: 2-((1-benzylpiperidin-4-yl)methyl)-2-bromo-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one

Conditions

Conditions	Yield
With hydrogen bromide; dimethyl sulfoxide In water; ethyl acetate at 60℃;	78%

Donepezil Chemical Properties

Molecular Structure:

Molecular Formula: C₂₄H₂₉NO₃
Molecular Weight: 379.492
IUPAC Name: 2-[(1-Benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one
Synonyms of Donepezil (CAS NO.120014-06-4): Donepezil [INN:BAN] ; UNII-8SSC91326P ; 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-
CAS NO: 120014-06-4
Classification Code: Central Nervous System Agents ; Cholinergic Agents ; Cholinesterase Inhibitors ; Enzyme Inhibitors ; Neurotransmitter Agents ; Nootropic Agents
Melting point: 207°C
Index of Refraction: 1.578
Molar Refractivity: 110.39 cm³
Molar Volume: 332.4 cm³
Surface Tension: 45.2 dyne/cm
Density: 1.141 g/cm³
Flash Point: 273.1 °C
Enthalpy of Vaporization: 80.26 kJ/mol
Boiling Point: 527.9 °C at 760 mmHg
Vapour Pressure: 3.11E-11 mmHg at 25°C

Donepezil Uses

Donepezil (CAS NO.120014-06-4) is used as an anti-dementia drug. Donepezil has been found to improve sleep apnea in Alzheimer's patients, it also can improve speech in children with autism.

Donepezil Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
women	TDLo	oral	1mg/kg (1mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE GASTROINTESTINAL: NAUSEA OR VOMITING	Annals of Pharmacotherpy. Vol. 33, Pg. 812, 1999.

Donepezil Safety Profile

Safety Information of Donepezil (CAS NO.120014-06-4):
Hazard Codes: Xi
Risk Statements: 36/37/38
36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 26-36
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
RIDADR: UN 2811

Product Name

2-[(1-Benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one

Synthetic route

Donepezil Chemical Properties

Donepezil Uses

Donepezil Toxicity Data With Reference

Donepezil Safety Profile

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