We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Specification : N-Benzylpiperidine-4-carboxaldehy
Cas:22065-85-6
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inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryProduct Description Product website: http://www.finerchem.com Product Name N-Benzylpiperidine-4-carboxaldehyde
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryN-Benzylpiperidine-4-carboxaldehyde Basic information Product Name: N-Benzylpiperidine-4-carboxaldehyde Synonyms: N-BENZYLPIPERIDINE-4-CARBOXALDEHYDE;1-BENZYL-PIPERIDINE-4-CARBALDEHYDE;1
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:22065-85-6
Min.Order:1 Kilogram
FOB Price: $100.0 / 150.0
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:22065-85-6
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:22065-85-6
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inquiryProduct Name: N-Benzylpiperidine-4-carboxaldehyde CAS: 22065-85-6 MF: C13H17NO MW: 203.28 EINECS: 244-757-7 Mol File: 22065-85-6.mol N-Benzylpiperidine-4-carboxaldehyde Structure N-Benzylpiperidine-4-carboxaldehyde Chemical Proper
Cas:22065-85-6
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:22065-85-6
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Specification:USP/EP Month production ablity:50kg/Month Low price& High quality Manufacturer Appearance:white powder Storage:Room Temperature Application:22065-85-6
Cas:22065-85-6
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:22065-85-6
Min.Order:4 Kilogram
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Type:Lab/Research institutions
inquiryHigh quality 22065-85-6 low price N-Benzylpiperidine-4-carboxaldehyde in China Molecular Formula C13H17NO Molar Mass 203.28 Density 1.026 g/mL at 25 °C Melting Point 145-149 °C Boling
Cas:22065-85-6
Min.Order:1 Gram
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Type:Other
inquiryChemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff
Cas:22065-85-6
Min.Order:100 Gram
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inquirySuperior quality, moderate price & quick delivery. Appearance:colourless or light yellow liquid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum, or as per your request. Application:Used as Pharmaceu
Cas:22065-85-6
Min.Order:1 Kilogram
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Type:Trading Company
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:22065-85-6
Min.Order:1 Kilogram
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inquiryOur Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
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Cas:22065-85-6
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inquiryWe Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O
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Min.Order:1 Kilogram
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inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:22065-85-6
Min.Order:1 Gram
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inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
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inquiryLocated in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h
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Min.Order:0
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Type:Manufacturers
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Min.Order:1 Kilogram
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Type:Other
inquiry1-benzylpiperidine-4-carbonitrile
1-benzyl-4-formylpiperidine
Conditions | Yield |
---|---|
Stage #1: 1-benzylpiperidine-4-carbonitrile With diisobutylaluminium hydride In toluene at 0℃; for 1h; Stage #2: With water; sodium hydroxide In methanol; toluene for 0.5h; pH=8; Temperature; | 97.5% |
1-benzyl-4-piperidinecarboxylic acid methyl ester
1-benzyl-4-formylpiperidine
Conditions | Yield |
---|---|
With red-aluminum/morpholine complex In toluene at -5 - 0℃; for 0.5h; Reagent/catalyst; Solvent; Inert atmosphere; Large scale; | 96.5% |
Multi-step reaction with 2 steps 1: 69.5 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 50 °C 2: 94.3 percent / oxalyl chloride; dimethyl sulfoxide; Et3N / CH2Cl2 / 0.25 h / -55 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: water; methanol; sodium hydroxide / 2 h / Reflux 2.1: thionyl chloride / 2 h / Reflux 2.2: 0.5 h / Cooling with ice 3.1: thionyl chloride / 5 h / Reflux 4.1: diisobutylaluminium hydride / toluene / 1 h / 0 °C 4.2: 0.5 h / pH 8 View Scheme |
1-benzyl-4-piperidinemethanol
1-benzyl-4-formylpiperidine
Conditions | Yield |
---|---|
With oxalyl dichloride; dimethyl sulfoxide; triethylamine In dichloromethane at -70 - 20℃; Swern Oxidation; | 96% |
With oxalyl dichloride; dimethyl sulfoxide; triethylamine In dichloromethane at -55℃; for 0.25h; Swern oxidation; | 94.3% |
Stage #1: 1-benzyl-4-piperidinemethanol With dimethylsulfide; triethylamine In toluene at -15 - -10℃; Inert atmosphere; Stage #2: With N-chloro-succinimide In toluene | 85% |
N-benzyl isonipecotic acid ethyl ester
1-benzyl-4-formylpiperidine
Conditions | Yield |
---|---|
With diisobutylaluminium hydride In hexane; toluene at -78℃; for 2.5h; Flow reactor; | 96% |
With Red-ALP-KTB In various solvent(s) at 10℃; | 95% |
Stage #1: N-benzyl isonipecotic acid ethyl ester With morpholine; diisobutylaluminium hydride In tetrahydrofuran; hexane at 0℃; for 3.16667h; Inert atmosphere; Stage #2: With lithium diisobutylmethoxy aluminum hydride In tetrahydrofuran; hexane at 0℃; for 0.166667h; Inert atmosphere; | 94% |
pyrrolidine
N-benzyl isonipecotic acid ethyl ester
A
1-benzyl-4-formylpiperidine
B
1-benzyl-4-piperidinemethanol
Conditions | Yield |
---|---|
With Red-ALP In various solvent(s) at 20℃; for 2h; | A 95% B n/a C n/a D n/a |
1-benzyl-1,2,3,6-tetrahydropyridine-4-carbaldehyde
1-benzyl-4-formylpiperidine
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In methanol at 20℃; for 3h; | 90% |
1-benzyl-4-formylpiperidine
Conditions | Yield |
---|---|
With sodium hydride; sodium iodide In tetrahydrofuran at 60℃; chemoselective reaction; | 75% |
1-benzyl-4-vinyl-piperidine
1-benzyl-4-formylpiperidine
Conditions | Yield |
---|---|
With PYRIMIDINE; sodium periodate; osmium(VIII) oxide In 1,4-dioxane; 2-methyl-propan-1-ol; water at 20℃; for 7h; | 74% |
1-benzyl-4-formylpiperidine
Conditions | Yield |
---|---|
Stage #1: C14H16NO3(1-)*Na(1+) With hydrogenchloride; water at 90℃; for 1.5 - 2h; Heating / reflux; Stage #2: With ammonia In water at 15℃; pH=8.5 - 9.0; Product distribution / selectivity; | 68% |
1-phenylmethyl-4-piperidone
diazomethyl-trimethyl-silane
1-benzyl-4-formylpiperidine
Conditions | Yield |
---|---|
Stage #1: diazomethyl-trimethyl-silane With n-butyllithium; diisopropylamine In tetrahydrofuran at -78℃; for 1.25h; Stage #2: 1-phenylmethyl-4-piperidone In tetrahydrofuran at -78 - 20℃; for 4h; Heating / reflux; | 55% |
With N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide |
1-benzyl-4-methoxymethyl-piperidine
1-benzyl-4-formylpiperidine
Conditions | Yield |
---|---|
Stage #1: 1-benzyl-4-methoxymethyl-piperidine With hydrogenchloride; methanol; water for 3h; Heating / reflux; Stage #2: With sodium hydroxide In water pH=12; | 54% |
1-Benzyl-4-(methoxymethylidene)-piperidine
1-benzyl-4-formylpiperidine
Conditions | Yield |
---|---|
Stage #1: 1-Benzyl-4-(methoxymethylidene)-piperidine With hydrogenchloride In methanol; water for 3h; Heating / reflux; Stage #2: With sodium hydroxide In water pH=12; | 54% |
With hydrogenchloride; potassium carbonate In tetrahydrofuran | |
With formic acid In water at 35℃; for 3h; Inert atmosphere; Large scale; | 57.7 kg |
N-benzyl-1-oxa-6-azaspiro[2,5]-octane
1-benzyl-4-formylpiperidine
Conditions | Yield |
---|---|
With magnesium bromide ethyl etherate In benzene at 40℃; for 0.333333h; | 17.5 g |
1-phenylmethyl-4-piperidone
1-benzyl-4-formylpiperidine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: tetrabutylammonium bromide; NaOH / toluene; H2O / 4 h / 80 °C 2: 17.5 g / magnesium bromide etherate / benzene / 0.33 h / 40 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: sodium t-butanolate / tetrahydrofuran / 1.5 h / 0 - 5 °C / Inert atmosphere; Large scale 1.2: 1 h / 5 °C / Large scale 2.1: formic acid / water / 3 h / 35 °C / Inert atmosphere; Large scale View Scheme |
N-benzyl-2-(4-methylphenylsulfonyl)acetamide
1-benzyl-4-formylpiperidine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: NaH / tetrahydrofuran / 0.25 h / 20 °C 1.2: 95 percent / tetrahydrofuran / 5 h / Heating 2.1: 90 percent / AlCl3; LiAlH4 / tetrahydrofuran / 3 h / 20 °C 3.1: 90 percent / HCl / acetone; H2O / 24 h / Heating 4.1: 90 percent / H2 / Pd/C / methanol / 3 h / 20 °C View Scheme |
1-benzyl-4-formylpiperidine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 90 percent / AlCl3; LiAlH4 / tetrahydrofuran / 3 h / 20 °C 2: 90 percent / HCl / acetone; H2O / 24 h / Heating 3: 90 percent / H2 / Pd/C / methanol / 3 h / 20 °C View Scheme |
1-benzyl-4-formylpiperidine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 90 percent / HCl / acetone; H2O / 24 h / Heating 2: 90 percent / H2 / Pd/C / methanol / 3 h / 20 °C View Scheme |
4-carbethoxypiperidine
1-benzyl-4-formylpiperidine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 93 percent / NaHCO3 / ethanol; H2O / 2 h / 80 °C 2: 95 percent / Red-ALP-KTB / various solvent(s) / 10 °C View Scheme | |
Multi-step reaction with 3 steps 1: 76 percent / K2CO3 / ethanol / 72 h / Ambient temperature 2: 61 percent / LiAlH4 / tetrahydrofuran / 18 h / Heating 3: 1.) DMSO, (COCl)2, 2.) Et3N / 1.) CH2Cl2, from -65 deg C to -60 deg C, 15 min, 2.) CH2Cl2, from -78 deg C to RT, 6 h View Scheme | |
Multi-step reaction with 3 steps 1.1: triethylamine / toluene / 10 - 75 °C / Large scale 2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 15 - 30 °C / Large scale 3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -65 - -45 °C / Large scale 3.2: 0.5 h / -50 - -45 °C / Large scale View Scheme |
benzyl chloride
1-benzyl-4-formylpiperidine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 93 percent / NaHCO3 / ethanol; H2O / 2 h / 80 °C 2: 95 percent / Red-ALP-KTB / various solvent(s) / 10 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 84 percent / SOCl2 / 20 h / 20 °C 2: 79.7 percent / Et3N / CH2Cl2 / 20 °C 3: 69.5 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 50 °C 4: 94.3 percent / oxalyl chloride; dimethyl sulfoxide; Et3N / CH2Cl2 / 0.25 h / -55 °C View Scheme |
methyl piperidine-4-carboxylate hydrochloride
1-benzyl-4-formylpiperidine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 79.7 percent / Et3N / CH2Cl2 / 20 °C 2: 69.5 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 50 °C 3: 94.3 percent / oxalyl chloride; dimethyl sulfoxide; Et3N / CH2Cl2 / 0.25 h / -55 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: triethylamine / methanol / 6 h / Reflux 2.1: water; methanol; sodium hydroxide / 2 h / Reflux 3.1: thionyl chloride / 2 h / Reflux 3.2: 0.5 h / Cooling with ice 4.1: thionyl chloride / 5 h / Reflux 5.1: diisobutylaluminium hydride / toluene / 1 h / 0 °C 5.2: 0.5 h / pH 8 View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 79.7 percent / Et3N / CH2Cl2 / 20 °C 2: 69.5 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 50 °C 3: 94.3 percent / oxalyl chloride; dimethyl sulfoxide; Et3N / CH2Cl2 / 0.25 h / -55 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 76 percent / K2CO3 / ethanol / 72 h / Ambient temperature 2: 61 percent / LiAlH4 / tetrahydrofuran / 18 h / Heating 3: 1.) DMSO, (COCl)2, 2.) Et3N / 1.) CH2Cl2, from -65 deg C to -60 deg C, 15 min, 2.) CH2Cl2, from -78 deg C to RT, 6 h View Scheme |
1-phenylmethyl-4-piperidone
(methoxymethyl)triphenylphosphonium chloride
1-benzyl-4-formylpiperidine
Conditions | Yield |
---|---|
Stage #1: (methoxymethyl)triphenylphosphonium chloride With n-butyllithium In diethyl ether; hexane at 0 - 20℃; for 0.5h; Stage #2: 1-phenylmethyl-4-piperidone In diethyl ether; hexane at 20℃; for 3h; Stage #3: With hydrogenchloride; sodium hydroxide more than 3 stages; |
benzyl chloride
1-benzyl-4-formylpiperidine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: triethylamine / toluene / 10 - 75 °C / Large scale 2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 15 - 30 °C / Large scale 3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -65 - -45 °C / Large scale 3.2: 0.5 h / -50 - -45 °C / Large scale View Scheme | |
Multi-step reaction with 3 steps 1.1: toluene / 2 h / 10 - 15 °C 1.2: 6 h / 70 °C 2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 0.25 h / 15 - 30 °C 3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -55 - -48 °C 3.2: 1.08 h / -55 - -20 °C View Scheme | |
Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / ethanol / 3 h / Reflux; Large scale 2: red-aluminum/morpholine complex / toluene / 0.5 h / -5 - 0 °C / Inert atmosphere; Large scale View Scheme | |
Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / ethanol / 3 h / Reflux 2: red-aluminum/morpholine complex / cyclohexane / 3 h / 0 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1.1: potassium carbonate / toluene / 0.25 h 1.2: 4 h / 100 °C 2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 2 h / 20 °C / Inert atmosphere 3.1: dimethyl sulfoxide; oxalyl dichloride; triethylamine / dichloromethane / -70 - 20 °C View Scheme |
1-benzyl-4-formylpiperidine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / ethanol / 3 h / Reflux; Large scale 2: red-aluminum/morpholine complex / toluene / 0.5 h / -5 - 0 °C / Inert atmosphere; Large scale View Scheme |
benzaldehyde
1-benzyl-4-formylpiperidine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogen; platinum on activated charcoal / toluene / 80 °C / Flow reactor 2: diisobutylaluminium hydride / toluene; hexane / 2.5 h / -78 °C / Flow reactor View Scheme |
1-benzyl-piperidine-4-carboxylic acid amide
1-benzyl-4-formylpiperidine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: thionyl chloride / 5 h / Reflux 2.1: diisobutylaluminium hydride / toluene / 1 h / 0 °C 2.2: 0.5 h / pH 8 View Scheme |
isonipecotic acid
1-benzyl-4-formylpiperidine
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: thionyl chloride / 2 h / Reflux 2.1: triethylamine / methanol / 6 h / Reflux 3.1: water; methanol; sodium hydroxide / 2 h / Reflux 4.1: thionyl chloride / 2 h / Reflux 4.2: 0.5 h / Cooling with ice 5.1: thionyl chloride / 5 h / Reflux 6.1: diisobutylaluminium hydride / toluene / 1 h / 0 °C 6.2: 0.5 h / pH 8 View Scheme |
5,6-dimethoxy-1-indanone
1-benzyl-4-formylpiperidine
1-benzyl-4-<(5,6-dimethoxy-1-oxoindan-2-ylidenyl)methyl>piperidine
Conditions | Yield |
---|---|
With potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In water; toluene at 20℃; Product distribution / selectivity; Inert atmosphere; Reflux; | 100% |
With sodium methylate In methanol; ethanol at 79℃; for 1.58333h; Product distribution / selectivity; Heating / reflux; | 93.4% |
With sodium methylate In methanol at 66℃; for 1h; Product distribution / selectivity; Heating / reflux; | 93.9% |
1-benzyl-4-formylpiperidine
tris-iso-propylsilyl acetylene
Conditions | Yield |
---|---|
With (αR,2S)-(-)-1-(2-diphenylphosphinobenzyl)-α-(2,2-dimethylpropynyl)-2-pyrrolidinemethanol; copper (I) tert-butoxide In tert-butyl alcohol at 25℃; for 72h; Inert atmosphere; enantioselective reaction; | 99% |
Conditions | Yield |
---|---|
With potassium fluoride In isopropyl alcohol at 20℃; | 96% |
1-benzyl-4-formylpiperidine
3-methoxyphenyl bromide
N-benzyl-4-[hydroxy(3-methoxyphenyl)methyl]piperidine
Conditions | Yield |
---|---|
Stage #1: 3-methoxyphenyl bromide With magnesium In tetrahydrofuran for 0.5h; Grignard reaction; Heating; Stage #2: N-benzyl-4-formylpiperidine In tetrahydrofuran at 20℃; for 2h; Addition; | 94.3% |
5,6-dimethoxy-1-indanone
1-benzyl-4-formylpiperidine
Conditions | Yield |
---|---|
With potassium tert-butylate In tert-butyl alcohol at 0 - 25℃; for 1.25h; Product distribution / selectivity; | 92.2% |
With sodium methylate In isopropyl alcohol at 0 - 25℃; for 3.25h; Product distribution / selectivity; | 92.5% |
With tetrabutylammomium bromide; potassium hydroxide In dichloromethane; water at 38℃; for 1.5h; | 90% |
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; for 0.5h; | 92% |
5,6-dimethoxy-1-indanone
1-benzyl-4-formylpiperidine
Conditions | Yield |
---|---|
Stage #1: 5,6-dimethoxy-1-indanone; N-benzyl-4-formylpiperidine In dichloromethane at 25 - 30℃; Stage #2: With potassium hydroxide In methanol; dichloromethane at 0 - 30℃; | 91.3% |
2-methylbenzothiazol-5-yl methyl ketone
1-benzyl-4-formylpiperidine
Conditions | Yield |
---|---|
With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.75h; | 90% |
1-benzyl-4-formylpiperidine
(4-chlorphenyl)magnesium bromide
(1-benzylpiperidin-4-yl)(4-chlorophenyl)methanol
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; for 0.55h; Grignard reaction; Inert atmosphere; | 90% |
Diethyl (2-oxopropyl)phosphonate
1-benzyl-4-formylpiperidine
(E)-4-(1-benzylpiperidin-4-yl)but-3-en-2-one
Conditions | Yield |
---|---|
Stage #1: Diethyl (2-oxopropyl)phosphonate With potassium carbonate In tetrahydrofuran at 20℃; for 0.583333h; Reflux; Stage #2: N-benzyl-4-formylpiperidine In tetrahydrofuran for 3h; Wittig reaction; Reflux; | 90% |
1-benzyl-4-formylpiperidine
5,6-Diethoxy-1-indanone
Conditions | Yield |
---|---|
With sodium methylate In tetrahydrofuran; methanol; water for 2h; | 89% |
1-benzyl-4-formylpiperidine
3-chloro-1-(3,4-dimethoxyphenyl)propan-1-one
1-benzyl-4-<(5,6-dimethoxy-1-oxoindan-2-ylidenyl)methyl>piperidine
Conditions | Yield |
---|---|
With triethylammonium tetrachloroaluminate at 55 - 175℃; for 11h; Temperature; Reagent/catalyst; Concentration; Inert atmosphere; | 89% |
Conditions | Yield |
---|---|
With aluminum oxide; Pt/Al2O3 In tetrahydrofuran; ethanol; water; isopropyl alcohol at 45 - 55℃; for 7h; Temperature; Solvent; Reagent/catalyst; Aldol Condensation; | 88% |
Multi-step reaction with 2 steps 1: sodium methylate / tetrahydrofuran 2: palladium 10% on activated carbon; hydrogenchloride / ethanol; water View Scheme |
1-benzyl-4-formylpiperidine
Conditions | Yield |
---|---|
Stage #1: (4-iodo-5-methoxypyrrolo[2,3-b]pyridin-1-yl)triisopropylsilane With isopropylmagnesium chloride In tetrahydrofuran at 0℃; for 0.666667h; Stage #2: N-benzyl-4-formylpiperidine In tetrahydrofuran at 0℃; for 1h; | 84.8% |
1-benzyl-4-formylpiperidine
Conditions | Yield |
---|---|
Stage #1: diethyl ((6-((2-methyl-1-oxo-1-(phenylamino)propan-2-yl)oxy)quinolin-2-yl)methyl)phosphonate With n-butyllithium In tetrahydrofuran at 0℃; for 0.166667h; Inert atmosphere; Stage #2: N-benzyl-4-formylpiperidine In tetrahydrofuran at 0 - 20℃; Inert atmosphere; | 84% |
1-benzyl-4-formylpiperidine
diethyl cyanomethyl phosphonate
(2E)-3-(1-benzylpiperidin-4-yl)prop-2-enenitrile
Conditions | Yield |
---|---|
Stage #1: diethyl cyanomethyl phosphonate With potassium carbonate In tetrahydrofuran at 20℃; for 0.5h; Reflux; Stage #2: N-benzyl-4-formylpiperidine In tetrahydrofuran for 12h; Reflux; | 83% |
5,6-dimethoxy-1-indanone
1-benzyl-4-formylpiperidine
2-((1-benzyl-piperidin-4-yl)-hydroxymethyl)-5,6-dimethoxyindan-1-one
Conditions | Yield |
---|---|
With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate In water; toluene for 4h; Reflux; Large scale; | 81.29% |
picolinic acid hydrazide
1-benzyl-4-formylpiperidine
Conditions | Yield |
---|---|
In methanol at 100℃; for 0.5h; Microwave irradiation; | 80% |
Conditions | Yield |
---|---|
With silver carbonate In toluene at 25℃; for 8h; diastereoselective reaction; | 79% |
1-benzyl-4-formylpiperidine
(3-fluorobenzyl)(triphenyl)phosphonium bromide
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; Cooling with ice; | 78.1% |
1-benzyl-4-formylpiperidine
2-bromo-5,6-dimethoxy-1-indanone
Conditions | Yield |
---|---|
With 1-phenylphospholane-1-oxide; diphenylsilane; N-ethyl-N,N-diisopropylamine In toluene at 100℃; for 24h; Wittig Olefination; Inert atmosphere; | 76% |
1-benzyl-4-formylpiperidine
diethyl (1-tritylimidazol-4-yl)methylphosphonate
Conditions | Yield |
---|---|
With potassium tert-butylate In tetrahydrofuran for 2h; Horner-Wadsworth-Emmons reaction; Heating; | 74% |
With potassium tert-butylate In tetrahydrofuran for 2h; Heating / reflux; | 74% |
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