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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Diethyl, (2-Oxopropyl)Phosphonate supplier in China

Cas:1067-71-6

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

he company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality se T rvice Appearance:Whit

Diethyl (2-Oxopropyl)phosphonate

Cas:1067-71-6

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Diethyl, (2-Oxopropyl)Phosphonate

Cas:1067-71-6

Min.Order:1

Negotiable

Type:Other

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product s

Diethyl (2-oxopropyl)phosphonate

Cas:1067-71-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(2-Oxopropyl)-phosphonic acid diethyl ester

Cas:1067-71-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

Diethyl (2-oxopropyl)phosphonate 1067-71-6

Cas:1067-71-6

Min.Order:1 Metric Ton

FOB Price: $500.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Wholesale price CAS 1067-71-6 with best price

Cas:1067-71-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Diethyl (2-oxopropyl)phosphonate

Cas:1067-71-6

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Phosphonic acid,P-(2-oxopropyl)-, diethyl ester 1067-71-6

Cas:1067-71-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Phosphonic acid,P-(2-oxopropyl)-, diethyl ester

Cas:1067-71-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Mojin Biotechnology Co.,Ltd

1. Customs clearance 1) By Express: Normally there is no specical need for the recipient to clear the customs. If the customs has an objection,our rich experienced and professional group will help you clear the customs. 2) By Air and by Sea: Our

Best Price CAS 1067-71-6 Diethyl (2-oxopropyl)phosphonate C7H15O4P 99%

Cas:1067-71-6

Min.Order:20 Kilogram

FOB Price: $10.0 / 25.0

Type:Trading Company

inquiry

Lonwin Chemical Group Limited

Diethyl (2-oxopropyl)phosphonate CAS: 1067-71-6 Specificatio Category Pharmaceutical Raw Materials, Fine Chemicals, Bulk drug Standard Medical standard Shelf life 2 years Storage should be stor

Factory supply Diethyl (2-oxopropyl)phosphonate

Cas:1067-71-6

Min.Order:1 Kilogram

FOB Price: $100.0 / 150.0

Type:Other

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Phosphonic acid,P-(2-oxopropyl)-, diethyl ester

Cas:1067-71-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Diethyl (2-Oxopropyl)Phosphonate

Cas:1067-71-6

Min.Order:0

Negotiable

Type:Manufacturers

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Phosphonic acid,P-(2-oxopropyl)-, diethyl ester

Cas:1067-71-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality Appearance:CLEAR COLORLESS TO LIGHT YELLOW LIQUID Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Used as Pharmaceutical Intermed

Diethyl (2-oxopropyl)phosphonate

Cas:1067-71-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Shanghai Minstar Chemical Co., Ltd

Diethyl (2-oxopropyl)phosphonate Basic information Product Name: Diethyl (2-oxopropyl)phosphonate Synonyms: Diethyl(2-oxopropyl)phosphonate, 97 %;DIETHYL ACETYLPHOSPHONATE;DIETHYL(2-OXOPROPYL)PHOSPHONATE;AURORA KA-1476;(2-Oxo-propyl)-phosphoni

Diethyl (2-oxopropyl)phosphonate

Cas:1067-71-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

1067-71-6 CAS NO.1067-71-6

Cas:1067-71-6

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

inquiry

Hangzhou ZeErRui Chemical Co., Ltd.

Product name: diethyl acetone phosphonate. Synonym:Diethyl(2-oxopropyl)phosphonate,97%;DIETHYLACETYLPHOSPHONATE;DIETHYL(2-OXOPROPYL)PHOSPHONATE;AURORAKA-1476;(2-Oxo-propyl)-phosphonicaciddiethylester;ACETYLPHOSPHONICACIDDIETHChemicalbookYLESTER;(

diethyl acetone phosphonate

Cas:1067-71-6

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Diethyl (2-oxopropyl)phosphonate

Cas:1067-71-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

Diethyl (2-oxopropyl)phosphonate cas no. 1067-71-6 98%

Cas:1067-71-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Suzhou Sibian Chemical Technology Co., Ltd

The process is mature and can be mass produced to 100 kg, with good quality and purity up to 99%.The product has a large stock and can be supplied stably. Package:bottle Application:Drug R&D Transportation:Sealed drying(25℃) Port:ShangHai

Diethyl (2-oxopropyl)phosphonate

Cas:1067-71-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

Diethyl(2-oxopropyl)phosphonate

Cas:1067-71-6

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

Diethyl (2-oxopropyl)phosphonate

Cas:1067-71-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

Diethyl(2-oxopropyl)phosphonate

Cas:1067-71-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

Diethyl, (2-Oxopropyl)Phosphonate

Cas:1067-71-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

Diethyl(2-oxopropyl)phosphonate

Cas:1067-71-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Diethyl(2-oxopropyl)phosphonate

Cas:1067-71-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU TIANYE CHEMICALS CO., LTD.

"HANGZHOU TIANYE CHEMICALS Co.LTD , Located in Eastern Science and Innovation Park Hangzhou .We are a high-tech enterprise specialized in technical research and development, production, development and trade of chemical products. We supply Multiple s

Diethyl (2-oxopropyl)phosphonate

Cas:1067-71-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

BOC Sciences

We are committed to providing our customers with the best products and services at the most competitive prices.Appearance:off-white powder Storage:Room temperature with sealed well Package:according to the clients requirement Application:Use as prima

Diethyl (2-oxopropyl)phosphonate

Cas:1067-71-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

1-bromoacetone
598-31-2

1-bromoacetone

triethyl phosphite
122-52-1

triethyl phosphite

Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

Conditions
ConditionsYield
for 2h; Reflux;100%
at 90℃; for 10h;68%
at 90 - 160℃;
[2-(Methoxycarbonyl-hydrazono)-propyl]-phosphonic acid diethyl ester
389827-60-5

[2-(Methoxycarbonyl-hydrazono)-propyl]-phosphonic acid diethyl ester

Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

Conditions
ConditionsYield
With hydrogenchloride; acetone for 3h; Ambient temperature;94%
phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

1-bromoacetone
598-31-2

1-bromoacetone

Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

Conditions
ConditionsYield
With C30H36B10CuO4P2; potassium carbonate at 20℃; for 7h; Time; Reagent/catalyst;93%
diethyl (2-hydroxy-4-oxopent-2-en-3-yl)phosphonate

diethyl (2-hydroxy-4-oxopent-2-en-3-yl)phosphonate

Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

Conditions
ConditionsYield
With dipotassium peroxodisulfate; silver(I) acetate In water; N,N-dimethyl-formamide at 85℃; for 24h; Inert atmosphere; Schlenk technique; chemoselective reaction;91%
diethyl (2-methylallyl)phosphonate
51533-70-1

diethyl (2-methylallyl)phosphonate

Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

Conditions
ConditionsYield
With dimethylsulfide; ozone In dichloromethane Oxidation;88%
acetic acid methyl ester
79-20-9

acetic acid methyl ester

Diethyl methylphosphonate
683-08-9

Diethyl methylphosphonate

Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

Conditions
ConditionsYield
With lithium diisopropyl amide In tetrahydrofuran at 0℃; for 4.5h;87%
With n-butyllithium In tetrahydrofuran at -78 - 20℃;
chloroacetone
78-95-5

chloroacetone

triethyl phosphite
122-52-1

triethyl phosphite

Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

Conditions
ConditionsYield
Stage #1: chloroacetone With potassium iodide In acetone at 20℃; for 2h;
Stage #2: triethyl phosphite In diethyl ether; acetone for 2h; Reflux;
85%
With potassium iodide In acetone; acetonitrile at 20 - 50℃; for 10h;83%
With sodium iodide In acetonitrile at 20℃;51%
diethyl 1-methylthio-2-oxo-n-propylphosphonate
151026-96-9

diethyl 1-methylthio-2-oxo-n-propylphosphonate

Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

Conditions
ConditionsYield
With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride In toluene for 1h; Heating;81%
((E)-2-Pyrrolidin-1-yl-propenyl)-phosphonic acid diethyl ester

((E)-2-Pyrrolidin-1-yl-propenyl)-phosphonic acid diethyl ester

Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

Conditions
ConditionsYield
With oxalic acid; silica gel In dichloromethane for 1h; Ambient temperature;80%
diethyl ester of 2-methylvinylphosphonic acid
5954-65-4

diethyl ester of 2-methylvinylphosphonic acid

Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

Conditions
ConditionsYield
With hydrogenchloride; water; oxygen; palladium dichloride at 85℃; for 20h;80%
Diethyl methylphosphonate
683-08-9

Diethyl methylphosphonate

XC(O)CH3

XC(O)CH3

Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

Conditions
ConditionsYield
With n-butyllithium; lithium diisopropyl amide In tetrahydrofuran; hexane at -60℃;78%
N-Acetylimidazole
2466-76-4

N-Acetylimidazole

diethylphosphonoacetic acid
3095-95-2

diethylphosphonoacetic acid

Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

Conditions
ConditionsYield
With triethylamine; magnesium chloride In acetonitrile at 20℃; for 24h; Acylation;77%
phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

acetylacetone
123-54-6

acetylacetone

Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

Conditions
ConditionsYield
With dipotassium peroxodisulfate; silver(I) acetate In water; N,N-dimethyl-formamide at 85℃; for 24h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; Inert atmosphere; Schlenk technique; chemoselective reaction;76%
iodoacetone
3019-04-3

iodoacetone

triethyl phosphite
122-52-1

triethyl phosphite

Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

Conditions
ConditionsYield
In diethyl ether Arbuzov reaction;75%
E-1-Methyl-3-oxo-1-pentenylphosphonsaeurediethylester
98732-76-4

E-1-Methyl-3-oxo-1-pentenylphosphonsaeurediethylester

A

Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

phosphonsaeure-diethylester

phosphonsaeure-diethylester

Conditions
ConditionsYield
With dihydrogen peroxide; sodium carbonate In methanol; water for 30h; Ambient temperature;A 6.9%
B 74%
E-1-Methyl-3-oxo-1-butenylphosphonsaeurediethylester
98732-74-2

E-1-Methyl-3-oxo-1-butenylphosphonsaeurediethylester

A

Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

(trans-3-Acetyl-2-methyl-2-oxiranyl)phosphonsaeure-diethylester

(trans-3-Acetyl-2-methyl-2-oxiranyl)phosphonsaeure-diethylester

Conditions
ConditionsYield
With dihydrogen peroxide; sodium carbonate In methanol; water at 20℃; for 48h;A 8.2%
B 72%
phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

acetone
67-64-1

acetone

Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

Conditions
ConditionsYield
With dipotassium peroxodisulfate; silver(I) acetate In water at 85℃; Inert atmosphere; Schlenk technique; chemoselective reaction;72%
chloroacetone
78-95-5

chloroacetone

triethyl phosphite
122-52-1

triethyl phosphite

A

Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

B

phosphoric acid diethyl ester isopropenyl ester
5954-28-9

phosphoric acid diethyl ester isopropenyl ester

Conditions
ConditionsYield
With potassium iodide In acetone; acetonitrile at 0℃; for 12h; Michaelis-Arbuzov reaction;A 70%
B n/a
2-methyl-2-phenylsulphonyloxirane
148599-29-5

2-methyl-2-phenylsulphonyloxirane

phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

Conditions
ConditionsYield
other substituted arylsulfonyl epoxides; multistep reaction: synthesis of β-keto phosphonates;70%
With sodium hydride 1) THF, mineral oil, rt, 10 min, 2) THF, rt, 30 min; Yield given. Multistep reaction;
-butyl vinyl ether
111-34-2

-butyl vinyl ether

diethyl 1-methylthio-2-oxo-n-propylphosphonate
151026-96-9

diethyl 1-methylthio-2-oxo-n-propylphosphonate

A

Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

B

[1-(2-Butoxy-ethyl)-2-oxo-propyl]-phosphonic acid diethyl ester

[1-(2-Butoxy-ethyl)-2-oxo-propyl]-phosphonic acid diethyl ester

C

(1-Acetyl-3,5-dibutoxy-pentyl)-phosphonic acid diethyl ester

(1-Acetyl-3,5-dibutoxy-pentyl)-phosphonic acid diethyl ester

Conditions
ConditionsYield
With n-butyl tin hydride; 2,2'-azobis(isobutyronitrile) In toluene for 1h; Heating; Yields of byproduct given;A n/a
B 70%
C n/a
With n-butyl tin hydride; 2,2'-azobis(isobutyronitrile) In toluene for 1h; Heating; Yields of byproduct given;A n/a
B n/a
C 37%
ethyl acetoacetate
141-97-9

ethyl acetoacetate

phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

Conditions
ConditionsYield
With dipotassium peroxodisulfate; silver(I) acetate In water; N,N-dimethyl-formamide at 85℃; for 24h; Inert atmosphere; Schlenk technique; chemoselective reaction;70%
phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

N,N-diethyl-3-oxobutanamide
2235-46-3

N,N-diethyl-3-oxobutanamide

Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

Conditions
ConditionsYield
With dipotassium peroxodisulfate; silver(I) acetate In water; N,N-dimethyl-formamide at 85℃; for 24h; Inert atmosphere; Schlenk technique; chemoselective reaction;66%
methyllithium
917-54-4

methyllithium

2-(diethoxyphosphinyl)-2-fluoro-acetic acid chloride
146036-63-7, 124050-38-0

2-(diethoxyphosphinyl)-2-fluoro-acetic acid chloride

A

Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

B

diethyl (1-fluoro-2-oxopropyl)phosphonate
124050-39-1

diethyl (1-fluoro-2-oxopropyl)phosphonate

Conditions
ConditionsYield
With copper(l) iodide; dimethylsulfide In tetrahydrofuran; diethyl ether 1.) from -78 deg C to -45 deg C; 2.) -45 deg C, 2.5 h;A 20%
B 62%
2-(diethoxyphosphinyl)-2-fluoro-acetic acid chloride
146036-63-7, 124050-38-0

2-(diethoxyphosphinyl)-2-fluoro-acetic acid chloride

MeCu*LiMe

MeCu*LiMe

A

Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

B

diethyl (1-fluoro-2-oxopropyl)phosphonate
124050-39-1

diethyl (1-fluoro-2-oxopropyl)phosphonate

Conditions
ConditionsYield
at -78 - -45℃; for 3h;A 20%
B 62%
N,N-Dimethylacetoacetamid
2044-64-6

N,N-Dimethylacetoacetamid

phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

Conditions
ConditionsYield
With dipotassium peroxodisulfate; silver(I) acetate In water; N,N-dimethyl-formamide at 85℃; for 24h; Inert atmosphere; Schlenk technique; chemoselective reaction;62%
benzyl acetoacetate
5396-89-4

benzyl acetoacetate

phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

Conditions
ConditionsYield
With dipotassium peroxodisulfate; silver(I) acetate In water; N,N-dimethyl-formamide at 85℃; for 24h; Inert atmosphere; Schlenk technique; chemoselective reaction;60%
phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

acetylacetone
123-54-6

acetylacetone

A

Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

B

diethyl (2-hydroxy-4-oxopent-2-en-3-yl)phosphonate

diethyl (2-hydroxy-4-oxopent-2-en-3-yl)phosphonate

Conditions
ConditionsYield
With dipotassium peroxodisulfate; silver(I) acetate In water; N,N-dimethyl-formamide at 85℃; for 4h; Time; Inert atmosphere; Schlenk technique; chemoselective reaction;A 58%
B 20%
With dipotassium peroxodisulfate; silver(I) acetate In water; N,N-dimethyl-formamide at 85℃; for 0.5h; Time; Inert atmosphere; Schlenk technique; chemoselective reaction;A 23%
B 53%
diethyl (2-chloro-2-oxoethyl)phosphonate
34170-81-5

diethyl (2-chloro-2-oxoethyl)phosphonate

methyllithium
917-54-4

methyllithium

Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

Conditions
ConditionsYield
With copper(l) iodide; dimethylsulfide In tetrahydrofuran; diethyl ether 1.) from -78 deg C to -45 deg C; 2.) -45 deg C, 2.5 h;55%
diethyl (2-chloro-2-oxoethyl)phosphonate
34170-81-5

diethyl (2-chloro-2-oxoethyl)phosphonate

(CH3)2CuLi

(CH3)2CuLi

Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

Conditions
ConditionsYield
In tetrahydrofuran; diethyl ether -78 deg C to -40 deg C; -40 deg C, 90 min;55%
diethyl ((2R,3R)-3-(hydroxymethyl)oxiran-2-yl)phosphonate

diethyl ((2R,3R)-3-(hydroxymethyl)oxiran-2-yl)phosphonate

Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

Conditions
ConditionsYield
With diethylamino-sulfur trifluoride In dichloromethane at -84 - 20℃; for 4h;51%
Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

benzaldehyde
100-52-7

benzaldehyde

(E)-benzalacetone
1896-62-4

(E)-benzalacetone

Conditions
ConditionsYield
With potassium carbonate In water at 20℃; for 15h;100%
With potassium carbonate In water at 20℃; for 18h;100%
With potassium carbonate In water at 20℃; for 18h; other aldehyde;100%
Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

(4-methoxyphenoxy)acetaldehyde
68426-09-5

(4-methoxyphenoxy)acetaldehyde

(E)-5-(4-methoxyphenoxy)pent-3-en-2-one

(E)-5-(4-methoxyphenoxy)pent-3-en-2-one

Conditions
ConditionsYield
With potassium carbonate In water at 0 - 20℃; for 1h; Wadsworth-Emmonds-Horner reaction;100%
3-phenyl-propionaldehyde
104-53-0

3-phenyl-propionaldehyde

Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

(E)-6-phenyl-3-hexen-2-one
33046-41-2, 56161-62-7

(E)-6-phenyl-3-hexen-2-one

Conditions
ConditionsYield
Stage #1: Diethyl (2-oxopropyl)phosphonate With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride In acetonitrile at 23℃; for 0.25h; Horner-Wadsworth-Emmons Olefination; Inert atmosphere;
Stage #2: 3-phenyl-propionaldehyde In acetonitrile at 0 - 23℃; for 0.5h; Inert atmosphere;
99%
With lithium hydroxide monohydrate In tetrahydrofuran at 0℃; for 2h;85%
Stage #1: Diethyl (2-oxopropyl)phosphonate With sodium hydride In tetrahydrofuran for 0.0833333h;
Stage #2: 3-phenyl-propionaldehyde In tetrahydrofuran
82%
Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

3-Benzyloxypropanal
19790-60-4

3-Benzyloxypropanal

(E)-6-(benzyloxy)hex-3-en-2-one
34591-98-5

(E)-6-(benzyloxy)hex-3-en-2-one

Conditions
ConditionsYield
With caesium carbonate In 1,4-dioxane; water at 20℃; for 3h; Inert atmosphere;99%
With lithium hydroxide In tetrahydrofuran at 0 - 23℃; Horner-Wadsworth-Emmons reaction;
Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

4-bromo-benzaldehyde
1122-91-4

4-bromo-benzaldehyde

(E)-4-(4-bromophenyl)but-3-ene-2-one
20511-04-0, 3815-31-4

(E)-4-(4-bromophenyl)but-3-ene-2-one

Conditions
ConditionsYield
With caesium carbonate In 1,4-dioxane; water at 20℃; for 3h; Inert atmosphere;99%
Stage #1: Diethyl (2-oxopropyl)phosphonate With sodium hydride In tetrahydrofuran at 0℃; for 0.5h;
Stage #2: 4-bromo-benzaldehyde In tetrahydrofuran at 0℃; for 2h; Horner-Emmons reaction;
81%
With lithium hydroxide In tetrahydrofuran at 0 - 23℃; Horner-Wadsworth-Emmons reaction;
With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran Horner-Emmons reaction;
pyridine-4-carbaldehyde
872-85-5

pyridine-4-carbaldehyde

Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

4-(pyridin-4-yl)-3-buten-2-one
94445-75-7

4-(pyridin-4-yl)-3-buten-2-one

Conditions
ConditionsYield
With caesium carbonate In 1,4-dioxane; water at 20℃; for 3h; Inert atmosphere;99%
Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

diethyl (+)-(R)-2-hydroxypropanephosphonate

diethyl (+)-(R)-2-hydroxypropanephosphonate

Conditions
ConditionsYield
With RuCl2((R)-binap)(dmf)n; hydrogen In methanol at 50℃; under 3040 Torr; for 50h;98%
With baker's yeast In water at 28 - 30℃; for 120h;78%
With Geotrichum candidum IFO 4597 In water; isopropyl alcohol at 30℃; for 96h;72%
With (R)-TriMe-NAPhePHOS; hydrogen bromide; hydrogen; [bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II) In ethanol at 50℃; under 7500.6 Torr; for 24h;
With Rhodotorula rubra; chloroacetic acid ethyl ester
Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

Ethyl-{5-[3-formyl-1-(tetrahydro-pyran-2-yl)-1H-indazol-5-yl]-4-methyl-pyridin-3-ylmethyl}-carbamic acid tert-butyl ester
837364-61-1

Ethyl-{5-[3-formyl-1-(tetrahydro-pyran-2-yl)-1H-indazol-5-yl]-4-methyl-pyridin-3-ylmethyl}-carbamic acid tert-butyl ester

Ethyl-{4-methyl-5-[3-(3-oxo-but-1-enyl)-1-(tetrahydro-pyran-2-yl)-1H-indazol-5-yl]-pyridin-3-ylmethyl}-carbamic acid tert-butyl ester

Ethyl-{4-methyl-5-[3-(3-oxo-but-1-enyl)-1-(tetrahydro-pyran-2-yl)-1H-indazol-5-yl]-pyridin-3-ylmethyl}-carbamic acid tert-butyl ester

Conditions
ConditionsYield
With potassium carbonate In tetrahydrofuran; water at 20℃; for 20h;98%
Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

diethyl (1-diazo-2-oxopropyl)phosphonate
21047-57-4

diethyl (1-diazo-2-oxopropyl)phosphonate

Conditions
ConditionsYield
With 4-toluenesulfonyl azide; triethylamine In acetonitrile Inert atmosphere;97%
With 4-acetamidobenzenesulfonyl azide; triethylamine In acetonitrile at 0 - 20℃;95%
With 4-toluenesulfonyl azide; sodium hydride In tetrahydrofuran91%
Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

4-(14-bromo-tetradec-2-ynyloxymethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester
472965-44-9

4-(14-bromo-tetradec-2-ynyloxymethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

4-[17-(diethoxy-phosphoryl)-16-oxo-heptadec-2-ynyloxymethyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester
472965-45-0

4-[17-(diethoxy-phosphoryl)-16-oxo-heptadec-2-ynyloxymethyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
Stage #1: Diethyl (2-oxopropyl)phosphonate With n-butyllithium; sodium hydride In tetrahydrofuran at -78℃;
Stage #2: 4-(14-bromo-tetradec-2-ynyloxymethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester In tetrahydrofuran Further stages.;
97%
Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

4-(4-methoxyphenyl)-3-buten-2-one
3815-30-3

4-(4-methoxyphenyl)-3-buten-2-one

Conditions
ConditionsYield
With caesium carbonate In 1,4-dioxane; water at 20℃; for 16h; Inert atmosphere;97%
With lithium hydroxide In tetrahydrofuran at 0 - 23℃; Horner-Wadsworth-Emmons reaction;
Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

m-tolyl aldehyde
620-23-5

m-tolyl aldehyde

(E)-4-(m-tolyl)but-3-en-2-one
15753-84-1, 95416-57-2

(E)-4-(m-tolyl)but-3-en-2-one

Conditions
ConditionsYield
With caesium carbonate In 1,4-dioxane; water at 20℃; for 3h; Inert atmosphere;97%
With potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene at 20℃; for 2h; Inert atmosphere;
Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

2-Phenylpropanal
34713-70-7

2-Phenylpropanal

5-phenyl-3-hexene-2-one
60405-50-7

5-phenyl-3-hexene-2-one

Conditions
ConditionsYield
barium dihydroxide In 1,4-dioxane at 70℃; for 0.166667h; Product distribution; further method; further 2-oxoalkanephosphonates;96%
barium dihydroxide In 1,4-dioxane at 70℃; for 0.166667h;96%
Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

(+/-)-3,3-dimethyl-2-phenylbutanal
86429-26-7

(+/-)-3,3-dimethyl-2-phenylbutanal

(E)-6,6-Dimethyl-5-phenyl-hept-3-en-2-one

(E)-6,6-Dimethyl-5-phenyl-hept-3-en-2-one

Conditions
ConditionsYield
barium dihydroxide In 1,4-dioxane at 70℃; for 0.25h;96%
Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

hept-2-ynal
1846-67-9

hept-2-ynal

trans-3-decen-5-yn-2-one
63922-98-5

trans-3-decen-5-yn-2-one

Conditions
ConditionsYield
With potassium carbonate In water96%
Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

4-nitrobenzaldehdye
555-16-8

4-nitrobenzaldehdye

urea
57-13-6

urea

5-(O,O-diethylphosphoryl)-6-methyl-4-(4-nitrophenyl)-3,4-dihydropyrimidin-2(1H)-one

5-(O,O-diethylphosphoryl)-6-methyl-4-(4-nitrophenyl)-3,4-dihydropyrimidin-2(1H)-one

Conditions
ConditionsYield
With toluene-4-sulfonic acid In acetonitrile for 24h; Biginelli Pyrimidone Synthesis; Reflux;96%
With zinc trifluoromethanesulfonate In toluene for 3h; Reflux; Green chemistry;86%
ytterbium trifluoromethanesulfonate In toluene for 12h; Heating;58%
Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

(R,S)-Diethyl-(2-hydroxypropyl)phosphonat
20180-08-9

(R,S)-Diethyl-(2-hydroxypropyl)phosphonat

Conditions
ConditionsYield
With sodium tetrahydroborate In ethanol at 0℃;95%
With pyridine; sodium tetrahydroborate In ethanol 1.) -30 deg C, 10 min, 2.) r.t., 45 min;89%
With diethyl ether Irradiation;
With sodium tetrahydroborate In ethanol for 2h; Reduction;
With sodium tetrahydroborate In methanol at 0 - 20℃;
Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

N,N-dimethyl-formamide dimethyl acetal
4637-24-5

N,N-dimethyl-formamide dimethyl acetal

diethoxyphosphinyl-3 N,N-dimethylamino-4 butene-3 one-2
98934-28-2

diethoxyphosphinyl-3 N,N-dimethylamino-4 butene-3 one-2

Conditions
ConditionsYield
With calcium chloride for 2h; Heating;95%
Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

N-butylamine
109-73-9

N-butylamine

N-[(1-methyl-2-diethoxyphosphoryl)ethyl]-N-n-butylamine
82101-95-9

N-[(1-methyl-2-diethoxyphosphoryl)ethyl]-N-n-butylamine

Conditions
ConditionsYield
With hydrogenchloride; sodium cyanoborohydride In methanol for 4h; Ambient temperature;95%
Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

ethyl N-phenylformimidate
6780-49-0

ethyl N-phenylformimidate

{2-Oxo-1-[1-phenylamino-meth-(E)-ylidene]-propyl}-phosphonic acid diethyl ester

{2-Oxo-1-[1-phenylamino-meth-(E)-ylidene]-propyl}-phosphonic acid diethyl ester

Conditions
ConditionsYield
at 130℃; for 8h;95%
Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

4-acetamidobenzenesulfonyl azide
2158-14-7

4-acetamidobenzenesulfonyl azide

diethyl (1-diazo-2-oxopropyl)phosphonate
21047-57-4

diethyl (1-diazo-2-oxopropyl)phosphonate

Conditions
ConditionsYield
With triethylamine In acetonitrile at 0 - 20℃; Inert atmosphere;95%
Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

ethyl (phenylhydrazono)chloroacetate
28663-68-5

ethyl (phenylhydrazono)chloroacetate

5-methyl-1-phenyl-1H-pyrazole-3-carboxylic acid ethyl ester
81153-64-2

5-methyl-1-phenyl-1H-pyrazole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With lithium hydroxide In 1,2-dimethoxyethane at 20℃; for 10h; regioselective reaction;95%
With lithium hydroxide In 1,2-dimethoxyethane at 20℃; for 10h; regioselective reaction;95%
With lithium hydroxide In 1,2-dimethoxyethane at 20℃; for 10h;
Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

methyl iodide
74-88-4

methyl iodide

(E)-9,9-Dimethoxy-non-3-en-2-one

(E)-9,9-Dimethoxy-non-3-en-2-one

Conditions
ConditionsYield
With sodium hydride94%
2-Ethylbutyraldehyde
97-96-1

2-Ethylbutyraldehyde

Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

5-ethyl-hept-3-en-2-one
147224-13-3

5-ethyl-hept-3-en-2-one

Conditions
ConditionsYield
With potassium carbonate In water at 100℃; for 0.166667h;93%
Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

α-diethoxyphosphoryl-α,α-dichloroacetone
111252-30-3

α-diethoxyphosphoryl-α,α-dichloroacetone

Conditions
ConditionsYield
With sulfuryl dichloride In dichloromethane for 2h;93%
With chlorine In tetrachloromethane at 0℃; for 2h;93%
Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

allyl bromide
106-95-6

allyl bromide

diethyl <2-hydroxy-2-methyl-4-pentenyl>phosphonate

diethyl <2-hydroxy-2-methyl-4-pentenyl>phosphonate

Conditions
ConditionsYield
With indium In tetrahydrofuran at 20℃; for 0.583333h;93%
With zinc 1.) THF, room temperature, 2.) THF, -78 deg C, 30 min; Yield given; Multistep reaction;
Diethyl (2-oxopropyl)phosphonate
1067-71-6

Diethyl (2-oxopropyl)phosphonate

3-hydroxy-2,2-dimethyl-6-methylenecyclohexanecarbaldehyde

3-hydroxy-2,2-dimethyl-6-methylenecyclohexanecarbaldehyde

8,8-dimethyl-2-methylene-6-oxabicyclo[3.2.1]octan-7-ol
357924-22-2

8,8-dimethyl-2-methylene-6-oxabicyclo[3.2.1]octan-7-ol

1-(8,8-dimethyl-2-methylene-6-oxabicyclo[3.2.1]oct-7-yl)acetone
357924-23-3

1-(8,8-dimethyl-2-methylene-6-oxabicyclo[3.2.1]oct-7-yl)acetone

Conditions
ConditionsYield
Stage #1: Diethyl (2-oxopropyl)phosphonate With barium dihydroxide at 140℃; for 2h;
Stage #2: 3-hydroxy-2,2-dimethyl-6-methylenecyclohexanecarbaldehyde; 8,8-dimethyl-2-methylene-6-oxabicyclo[3.2.1]octan-7-ol In tetrahydrofuran; water at 20℃; for 30h; Further stages.;
92%

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