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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Topotecan Manufacturer/High quality/Best price/In stock

Cas:123948-87-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Topotecan 123948-87-8 GMP Manufacturer

Cas:123948-87-8

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Topotecan

Cas:123948-87-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFU-CHEM 123948-87-8 Topotecan

Cas:123948-87-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Topotecan CAS 123948-87-8

Cas:123948-87-8

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 123948-87-8 with competitive price

Cas:123948-87-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

1 Topotecan is an antineoplastic agent used to treat small cell lung cancer, and certain cancers of the ovary. 2 Topotecan is also used to treat relapse of small cell lung cancer that initially responded to other drugs. Increases in survival tim

Topotecan

Cas:123948-87-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white crystalline needles Storage:Store in sealed containers

98% Topotecan CAS 123948-87-8 white crystalline powder

Cas:123948-87-8

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Topotecan 123948-87-8

Cas:123948-87-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Leader Biochemical Group

About Product Details Items Specifications Test Results Appearance White to white crystalline powde

Supply High Quality Topotecan CAS 123948-87-8 For research Use only

Cas:123948-87-8

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Topotecan

Cas:123948-87-8

Min.Order:10 Gram

FOB Price: $280.0 / 300.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Topotecan CAS:123948-87-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

Topotecan CAS:123948-87-8

Cas:123948-87-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Topotecan

Cas:123948-87-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

Topotecan Hydrochloride(TPT) CAS123948-87-8

Cas:123948-87-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Topotecan

Cas:123948-87-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Binbo Biological Co., Ltd

1.high purity 2.consistent quality 3.competitive price 4.fast shipping Binbo Biological Products Co. Ltd., is a professional high-tech enterprise which engaged in Biological products raw materials. Binbo is engaged in R&D with perfect equipm

High Quality Topotecan

Cas:123948-87-8

Min.Order:1 Kilogram

FOB Price: $0.1 / 0.2

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Topotecan

Cas:123948-87-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality Appearance:Off-white Cryst Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:antineoplastic;DNA topoisomerase type 1 inhibitor Tran

Topotecan

Cas:123948-87-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Topotecan

Cas:123948-87-8

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providing h

Factory Supply Topotecan

Cas:123948-87-8

Min.Order:0

Negotiable

Type:Other

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

High purity Topotecan

Cas:123948-87-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED

TopotecanCAS NO.: 123948-87-8

Cas:123948-87-8

Min.Order:1 Gram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Topotecan

Cas:123948-87-8

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Topotecan

Cas:123948-87-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Topotecan

Cas:123948-87-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

SAGECHEM/Topotecan/SAGECHEM/Manufacturer in China

Cas:123948-87-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

shanghai Tauto Biotech Co., Ltd

Been tested by at least three liquid-phase detection system. Annually retest will be made to ensure product quality. Being confirmed by mass spectrometry(MS) and nuclear resonance(NMR) HPLC and COA will be shipped togther with goods. Stor

Topotecan 123948-87-8 HPLC 98%

Cas:123948-87-8

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Luhan Pharmachem Co., Lt

Luhan Pharmachem Co., Ltd. owns strong elite professional quality sales force, has the customer base from the US, Europe, Japan, Southeast Asia, Korea, Hong Kong, Taiwan and other countries and regions, the company operates in accordance with the mod

Topotecan

Cas:123948-87-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Vanz Pharm Co.,Ltd

ISO Factory/Good qualityAppearance:off white Storage:dry and cool place Package:10G/BAG; 1KG/BAG ;25KG/DRUM Application:Active pharaceutical ingredients Transportation:BY SEA,AIR,EXPRESS Port:shenzhen/shanghai

Topotecan

Cas:123948-87-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Synthetic route

formaldehyd
50-00-0

formaldehyd

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

dimethyl amine
124-40-3

dimethyl amine

topotecan
123948-87-8

topotecan

Conditions
ConditionsYield
With acetic acid Mannich reaction;65%
In acetic acid at 40 - 90℃; Mannich Aminomethylation;
dichloromethane
75-09-2

dichloromethane

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

dimethyl amine
124-40-3

dimethyl amine

topotecan
123948-87-8

topotecan

Conditions
ConditionsYield
With potassium carbonate at 20℃; for 5h; Mannich reaction;65%
camptothecin
7689-03-4

camptothecin

topotecan
123948-87-8

topotecan

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: H2; AcOH / PtO2
1.2: 51 percent / Pb(OAc)4; AcOH
2.1: 65 percent / aq. AcOH
View Scheme
(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

N,N-dimethyl(methylene)ammonium chloride
30354-18-8

N,N-dimethyl(methylene)ammonium chloride

topotecan
123948-87-8

topotecan

Conditions
ConditionsYield
With triethylamine In dichloromethane; isopropyl alcohol at 20 - 35℃; for 12h; Mannich Reaction;
triethylsilyl chloride
994-30-9

triethylsilyl chloride

topotecan
123948-87-8

topotecan

20-OTES topotecan
1004511-35-6

20-OTES topotecan

Conditions
ConditionsYield
Stage #1: topotecan With 1H-imidazole In N,N-dimethyl-formamide for 0.166667h; Inert atmosphere;
Stage #2: triethylsilyl chloride With dmap In N,N-dimethyl-formamide
94%
With 1H-imidazole; dmap In N,N-dimethyl-formamide for 52.1667h;94%
topotecan
123948-87-8

topotecan

tert-butyl (2-isocyanatoethyl)carbamate
284049-22-5

tert-butyl (2-isocyanatoethyl)carbamate

(S)-tert-butyl (10-((dimethylamino)methyl)-4-ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl) ethane-1,2-diyldicarbamate

(S)-tert-butyl (10-((dimethylamino)methyl)-4-ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl) ethane-1,2-diyldicarbamate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide; acetonitrile at 0 - 20℃; for 2h;69%
topotecan
123948-87-8

topotecan

tert-butyl 2-isocyanatoacetate
113238-61-2

tert-butyl 2-isocyanatoacetate

(S)-tert-butyl 2-((((10-((dimethylamino)methyl)-4-ethyl-4- hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl)oxy)carbonyl)amino)acetate

(S)-tert-butyl 2-((((10-((dimethylamino)methyl)-4-ethyl-4- hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl)oxy)carbonyl)amino)acetate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide; acetonitrile at 0 - 20℃; for 2h;68%
topotecan
123948-87-8

topotecan

[11C]methyl triflate
145577-00-0

[11C]methyl triflate

9-[([11C]trimethylammonium)methyl]-10-hydroxy-20(S)-camptothecin triflate

9-[([11C]trimethylammonium)methyl]-10-hydroxy-20(S)-camptothecin triflate

Conditions
ConditionsYield
In acetonitrile60%
In acetonitrile at -15 - 80℃;
topotecan
123948-87-8

topotecan

Topotecan hydroxyl acid

Topotecan hydroxyl acid

Conditions
ConditionsYield
With phosphate buffer Ambient temperature; other camptothecin lactone; also in the presence of DNA oligonucleotides; rate of hydrolysis;
With poly(DL-lactide-co-glycolide); poly(vinyl alcohol) In various solvents at 37℃; for 192h; pH=7.4; Product distribution; Kinetics; Further Variations:; reaction times; Hydrolysis;
With water at 37℃;
topotecan
123948-87-8

topotecan

Topotecan hydrochloride
119413-54-6, 123949-07-5

Topotecan hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In methanol; water at 10 - 30℃; for 2h; Product distribution / selectivity;
topotecan
123948-87-8

topotecan

methyl trifluoromethanesulfonate
333-27-7

methyl trifluoromethanesulfonate

A

9-[(trimethylammonium)methyl]-10-hydroxy-20(S)-camptothecin triflate

9-[(trimethylammonium)methyl]-10-hydroxy-20(S)-camptothecin triflate

B

C21H18N2O6
175613-38-4

C21H18N2O6

C

CHF3O3S*C23H23N3O5
1243272-93-6

CHF3O3S*C23H23N3O5

D

CF3O3S(1-)*C25H28N3O5(1+)

CF3O3S(1-)*C25H28N3O5(1+)

Conditions
ConditionsYield
Stage #1: methyl trifluoromethanesulfonate With potassium carbonate In dichloromethane for 0.5h;
Stage #2: topotecan In dichloromethane at 20℃; for 24h;
Methyl methanesulfonate
66-27-3

Methyl methanesulfonate

topotecan
123948-87-8

topotecan

A

C21H18N2O6
175613-38-4

C21H18N2O6

B

CH4O3S*C23H23N3O5

CH4O3S*C23H23N3O5

C

CH3O3S(1-)*C25H28N3O5(1+)

CH3O3S(1-)*C25H28N3O5(1+)

D

10-hydroxy-9-<(trimethylammonio)methyl>-(20S)-camptothecin methanosulfonate
123948-98-1

10-hydroxy-9-<(trimethylammonio)methyl>-(20S)-camptothecin methanosulfonate

Conditions
ConditionsYield
Stage #1: Methyl methanesulfonate With potassium carbonate In dichloromethane for 0.5h;
Stage #2: topotecan In dichloromethane at 20℃; for 24h;
topotecan
123948-87-8

topotecan

25,26,27,28-terahydroxycalix[4]arene-5,11,7,23-tetrasulfonic acid
386768-13-4, 189397-70-4, 112269-92-8

25,26,27,28-terahydroxycalix[4]arene-5,11,7,23-tetrasulfonic acid

C23H23N3O5*C28H24O16S4

C23H23N3O5*C28H24O16S4

Conditions
ConditionsYield
In methanol; water at 20℃; for 48h;
topotecan
123948-87-8

topotecan

topotecan lactam

topotecan lactam

Conditions
ConditionsYield
Stage #1: topotecan With isopropylamine
Stage #2: With pyridine; acetic anhydride
Stage #3: With ammonia In dichloromethane
Stage #1: topotecan With isopropylamine
Stage #2: With pyridine; acetic anhydride
Stage #3: With ammonia In dichloromethane
topotecan
123948-87-8

topotecan

C26H28N4O6

C26H28N4O6

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 66 h / 20 °C
2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
View Scheme
topotecan
123948-87-8

topotecan

(S)-7-((10-((dimethylamino)methyl)-4-ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl)oxy)heptanoic acid

(S)-7-((10-((dimethylamino)methyl)-4-ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl)oxy)heptanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 24 h / Heating
2: lithium hydroxide; water / tetrahydrofuran / 6 h / 20 °C
View Scheme
topotecan
123948-87-8

topotecan

(S)-7-((10-((dimethylamino)methyl)-4-ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl)oxy)-N-(5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl)heptanamide

(S)-7-((10-((dimethylamino)methyl)-4-ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl)oxy)-N-(5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl)heptanamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 24 h / Heating
2: lithium hydroxide; water / tetrahydrofuran / 6 h / 20 °C
3: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere
View Scheme
succinic acid anhydride
108-30-5

succinic acid anhydride

topotecan
123948-87-8

topotecan

9-dimethylaminomethyl-hydroxycamptothecin-10-succinic acid

9-dimethylaminomethyl-hydroxycamptothecin-10-succinic acid

Conditions
ConditionsYield
With pyridine at 50℃; for 48h;0.35 g
topotecan
123948-87-8

topotecan

C62H70N7O20P

C62H70N7O20P

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine / 48 h / 50 °C
2: 1,1'-carbonyldiimidazole; 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 24 h / 20 °C
View Scheme

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