As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
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inquiry1 Topotecan is an antineoplastic agent used to treat small cell lung cancer, and certain cancers of the ovary. 2 Topotecan is also used to treat relapse of small cell lung cancer that initially responded to other drugs. Increases in survival tim
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryAbout Product Details Items Specifications Test Results Appearance White to white crystalline powde
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Topotecan CAS:123948-87-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
1.high purity 2.consistent quality 3.competitive price 4.fast shipping Binbo Biological Products Co. Ltd., is a professional high-tech enterprise which engaged in Biological products raw materials. Binbo is engaged in R&D with perfect equipm
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inquirySuperior quality Appearance:Off-white Cryst Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:antineoplastic;DNA topoisomerase type 1 inhibitor Tran
Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providing h
Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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inquiryWe are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED
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Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
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SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe
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inquiryBeen tested by at least three liquid-phase detection system. Annually retest will be made to ensure product quality. Being confirmed by mass spectrometry(MS) and nuclear resonance(NMR) HPLC and COA will be shipped togther with goods. Stor
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formaldehyd
(S)-10-hydroxycamptothecin
dimethyl amine
topotecan
Conditions | Yield |
---|---|
With acetic acid Mannich reaction; | 65% |
In acetic acid at 40 - 90℃; Mannich Aminomethylation; |
dichloromethane
(S)-10-hydroxycamptothecin
dimethyl amine
topotecan
Conditions | Yield |
---|---|
With potassium carbonate at 20℃; for 5h; Mannich reaction; | 65% |
camptothecin
topotecan
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: H2; AcOH / PtO2 1.2: 51 percent / Pb(OAc)4; AcOH 2.1: 65 percent / aq. AcOH View Scheme |
(S)-10-hydroxycamptothecin
N,N-dimethyl(methylene)ammonium chloride
topotecan
Conditions | Yield |
---|---|
With triethylamine In dichloromethane; isopropyl alcohol at 20 - 35℃; for 12h; Mannich Reaction; |
Conditions | Yield |
---|---|
Stage #1: topotecan With 1H-imidazole In N,N-dimethyl-formamide for 0.166667h; Inert atmosphere; Stage #2: triethylsilyl chloride With dmap In N,N-dimethyl-formamide | 94% |
With 1H-imidazole; dmap In N,N-dimethyl-formamide for 52.1667h; | 94% |
topotecan
tert-butyl (2-isocyanatoethyl)carbamate
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide; acetonitrile at 0 - 20℃; for 2h; | 69% |
topotecan
tert-butyl 2-isocyanatoacetate
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide; acetonitrile at 0 - 20℃; for 2h; | 68% |
topotecan
[11C]methyl triflate
Conditions | Yield |
---|---|
In acetonitrile | 60% |
In acetonitrile at -15 - 80℃; |
topotecan
Conditions | Yield |
---|---|
With phosphate buffer Ambient temperature; other camptothecin lactone; also in the presence of DNA oligonucleotides; rate of hydrolysis; | |
With poly(DL-lactide-co-glycolide); poly(vinyl alcohol) In various solvents at 37℃; for 192h; pH=7.4; Product distribution; Kinetics; Further Variations:; reaction times; Hydrolysis; | |
With water at 37℃; |
topotecan
Topotecan hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water at 10 - 30℃; for 2h; Product distribution / selectivity; |
topotecan
methyl trifluoromethanesulfonate
B
C21H18N2O6
C
CHF3O3S*C23H23N3O5
Conditions | Yield |
---|---|
Stage #1: methyl trifluoromethanesulfonate With potassium carbonate In dichloromethane for 0.5h; Stage #2: topotecan In dichloromethane at 20℃; for 24h; |
Methyl methanesulfonate
topotecan
A
C21H18N2O6
D
10-hydroxy-9-<(trimethylammonio)methyl>-(20S)-camptothecin methanosulfonate
Conditions | Yield |
---|---|
Stage #1: Methyl methanesulfonate With potassium carbonate In dichloromethane for 0.5h; Stage #2: topotecan In dichloromethane at 20℃; for 24h; |
topotecan
25,26,27,28-terahydroxycalix[4]arene-5,11,7,23-tetrasulfonic acid
Conditions | Yield |
---|---|
In methanol; water at 20℃; for 48h; |
topotecan
Conditions | Yield |
---|---|
Stage #1: topotecan With isopropylamine Stage #2: With pyridine; acetic anhydride Stage #3: With ammonia In dichloromethane | |
Stage #1: topotecan With isopropylamine Stage #2: With pyridine; acetic anhydride Stage #3: With ammonia In dichloromethane |
topotecan
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 66 h / 20 °C 2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C View Scheme |
topotecan
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium carbonate / N,N-dimethyl-formamide / 24 h / Heating 2: lithium hydroxide; water / tetrahydrofuran / 6 h / 20 °C View Scheme |
topotecan
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: potassium carbonate / N,N-dimethyl-formamide / 24 h / Heating 2: lithium hydroxide; water / tetrahydrofuran / 6 h / 20 °C 3: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere View Scheme |
succinic acid anhydride
topotecan
Conditions | Yield |
---|---|
With pyridine at 50℃; for 48h; | 0.35 g |
topotecan
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: pyridine / 48 h / 50 °C 2: 1,1'-carbonyldiimidazole; 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 24 h / 20 °C View Scheme |
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