As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:130018-77-8
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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Cas:130018-77-8
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inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryProduct Name Levocetirizine CAS 130018-77-8 Molecular formula C21H27Cl3N2O3 Molecular weight 461.8097 Appearance:White powder St
1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryProduct Name: Levocetirizine Synonyms: LEVOCETIRIZINE;alerlisin;2-[2-[4-[(R)-(4-chlorophenyl)-phenylmethyl]-1-piperazinyl]ethoxy]acetic acid;Cetirizine Impurity 20;(R)-2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetic acid;LE
Levocetirizine CAS:130018-77-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermedi
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Cas:130018-77-8
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Cas:130018-77-8
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:130018-77-8
Min.Order:10 Gram
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inquiry1. A strong scientific research team . 2. Stable quality (with a complete scientific research center and testing center to ensure the quality stability of each batch of products). 3. Rich export experience (with practical experience in exporting to m
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:130018-77-8
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inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:130018-77-8
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inquiryProduct name:Levocetirizine HCL CAS No.:130018-77-8 Molecule Formula:C21H27Cl3N2O3 Molecule Weight:461.80 Purity: 98.5% Package: 25kg/drum Description:White crystals powder Manufacture Standards:Enterprise Standard
Cas:130018-77-8
Min.Order:1 Kilogram
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Type:Trading Company
inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
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Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:130018-77-8
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Type:Lab/Research institutions
inquiryAppearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea
High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:Active Pharmaceutical I
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high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier
levocetirizine
Conditions | Yield |
---|---|
With lithium hydroxide In tetrahydrofuran; methanol; water at 65℃; for 2h; | 90% |
(2-chloroethoxy)-acetic acid
(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
levocetirizine
Conditions | Yield |
---|---|
With tetrabutylammomium bromide; sodium hydride In N,N-dimethyl-formamide at 95℃; for 5h; Inert atmosphere; | 86.5% |
levocetirizine
Conditions | Yield |
---|---|
With hydrogenchloride In water Large scale; enantioselective reaction; | 74% |
Stage #1: (R)-(2-{4-[(4-chlorophenyl)phenylmethyl]piperazin-1-yl}ethoxy)acetic acid methyl ester With water; potassium hydroxide In methanol at 80℃; for 1h; Stage #2: With hydrogenchloride In dichloromethane; water pH=4 - 4.5; Product distribution / selectivity; |
levocetirizine N-benzyl amide
levocetirizine
Conditions | Yield |
---|---|
Stage #1: levocetirizine N-benzyl amide With sulfuric acid In methanol for 16h; Reflux; Stage #2: With sodium hydroxide In methanol for 2h; pH=10 - 12; Stage #3: With hydrogenchloride In methanol; water pH=4.5; | 70% |
Stage #1: levocetirizine N-benzyl amide With sulfuric acid; water at 80 - 85℃; for 8h; Stage #2: With sodium hydroxide In water pH=4.0 - 4.5; | n/a |
(R)-2-(2-{4-[(4-chlorophenyl)phenylmethyl]piperazin-1-yl}ethoxy)acetamide
levocetirizine
Conditions | Yield |
---|---|
With hydrogenchloride In water at 65℃; for 4h; | |
Multi-step reaction with 2 steps 1.1: hydrogenchloride / methanol / 4 h / Reflux 1.2: 7 h 2.1: hydrogenchloride / water / Large scale View Scheme |
(+)-[2-[4-[(4-chlorophenyl)-phenyl methyl]-1-piperazinyl]]ethanol
sodium monochloroacetic acid
levocetirizine
Conditions | Yield |
---|---|
Stage #1: (+)-[2-[4-[(4-chlorophenyl)-phenyl methyl]-1-piperazinyl]]ethanol With potassium hydroxide In N,N-dimethyl-formamide at 0 - 5℃; for 1.5h; Stage #2: sodium monochloroacetic acid at 0 - 5℃; for 1.5h; Stage #3: at 30 - 35℃; | |
Stage #1: (+)-[2-[4-[(4-chlorophenyl)-phenyl methyl]-1-piperazinyl]]ethanol With potassium hydroxide In DMF (N,N-dimethyl-formamide) at 0 - 5℃; for 1.5h; Stage #2: sodium monochloroacetic acid In DMF (N,N-dimethyl-formamide) at 0 - 35℃; Stage #3: With hydrogenchloride In DMF (N,N-dimethyl-formamide); water pH=4 - 4.5; |
(R)-2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-1-(S)-[N-(1-phenyIethyl)]acetamide
levocetirizine
Conditions | Yield |
---|---|
With water; hydrogen bromide at 90 - 95℃; for 24h; Product distribution / selectivity; | |
Stage #1: (R)-2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-1-(S)-[N-(1-phenyIethyl)]acetamide With sulfuric acid; water at 80 - 85℃; for 48h; Stage #2: With sodium hydroxide In water pH=4.5 - 5.0; Product distribution / selectivity; |
Conditions | Yield |
---|---|
Resolution of racemate; | |
With N,N-diethylaniline In hexane; isopropyl alcohol at 25℃; Reagent/catalyst; Resolution of racemate; | |
With maltodextrin In aq. buffer at 25℃; pH=3; Reagent/catalyst; pH-value; Temperature; Resolution of racemate; |
Conditions | Yield |
---|---|
Stage #1: C19H23ClN2O*ClH With ammonia In water; toluene for 0.25h; pH=8.5 - 9; Stage #2: sodium monochloroacetic acid With potassium hydroxide In N,N-dimethyl-formamide at 0 - 10℃; Stage #3: With hydrogenchloride In dichloromethane; water pH=4.3 - 4.8; |
(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
levocetirizine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: triethylamine / toluene / 7 h / 110 - 115 °C 1.2: 12 h / 25 - 30 °C 2.1: ammonia / toluene; water / 0.25 h / pH 8.5 - 9 2.2: 0 - 10 °C 2.3: pH 4.3 - 4.8 View Scheme | |
Multi-step reaction with 5 steps 1.1: tetrabutylammomium bromide / dimethyl sulfoxide / 10 h 2.1: oxalyl dichloride / tetrahydrofuran / 0 - 5 °C 3.1: tetrahydrofuran 4.1: dimethylsulfide borane complex / tetrahydrofuran / Reflux 5.1: water; potassium hydroxide / methanol / 1 h / 80 °C 5.2: pH 4 - 4.5 View Scheme |
(R)-(4-chlorophenyl)(phenyl)methylamine
levocetirizine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: N-ethyl-N,N-diisopropylamine / 128 - 130 °C 2.1: potassium hydroxide / isopropyl alcohol / 9 h / 80 - 85 °C 3.1: triethylamine / toluene / 7 h / 110 - 115 °C 3.2: 12 h / 25 - 30 °C 4.1: ammonia / toluene; water / 0.25 h / pH 8.5 - 9 4.2: 0 - 10 °C 4.3: pH 4.3 - 4.8 View Scheme | |
Multi-step reaction with 6 steps 1.1: N-ethyl-N,N-diisopropylamine / 3 h / Reflux 1.2: 60 °C / Reflux 2.1: tetrabutylammomium bromide / dimethyl sulfoxide / 10 h 3.1: oxalyl dichloride / tetrahydrofuran / 0 - 5 °C 4.1: tetrahydrofuran 5.1: dimethylsulfide borane complex / tetrahydrofuran / Reflux 6.1: water; potassium hydroxide / methanol / 1 h / 80 °C 6.2: pH 4 - 4.5 View Scheme | |
Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine / 3 h / 120 °C 2: sodium hydride; sodium iodide / N,N-dimethyl-formamide; acetone / 3 h / 25 °C 3: lithium hydroxide / water; tetrahydrofuran; methanol / 2 h / 65 °C View Scheme |
levocetirizine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium hydroxide / water / 0.5 h / 65 - 70 °C 2.1: triethylamine / toluene / 7 h / 110 - 115 °C 2.2: 12 h / 25 - 30 °C 3.1: ammonia / toluene; water / 0.25 h / pH 8.5 - 9 3.2: 0 - 10 °C 3.3: pH 4.3 - 4.8 View Scheme |
C22H27ClN2O2
levocetirizine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: potassium hydroxide / isopropyl alcohol / 9 h / 80 - 85 °C 2.1: triethylamine / toluene / 7 h / 110 - 115 °C 2.2: 12 h / 25 - 30 °C 3.1: ammonia / toluene; water / 0.25 h / pH 8.5 - 9 3.2: 0 - 10 °C 3.3: pH 4.3 - 4.8 View Scheme |
N-benzyl-2-(2-(bis(2-chloroethyl)amino)ethoxy)acetamide
(R)-(4-chlorophenyl)(phenyl)methylamine
levocetirizine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: N-ethyl-N,N-diisopropylamine / 4 h / 130 °C / Inert atmosphere 2.1: sulfuric acid / methanol / 16 h / Reflux 2.2: 2 h / pH 10 - 12 2.3: pH 4.5 View Scheme |
p-chlorobenzhydrylamine
levocetirizine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: hydrogenchloride; borane-ammonia complex / aq. phosphate buffer / 37 °C / pH 7.8 2.1: N-ethyl-N,N-diisopropylamine / 4 h / 130 °C / Inert atmosphere 3.1: sulfuric acid / methanol / 16 h / Reflux 3.2: 2 h / pH 10 - 12 3.3: pH 4.5 View Scheme | |
Multi-step reaction with 4 steps 1: L-Tartaric acid / 30 - 90 °C / Inert atmosphere 2: N-ethyl-N,N-diisopropylamine / 3 h / 120 °C 3: sodium hydride; sodium iodide / N,N-dimethyl-formamide; acetone / 3 h / 25 °C 4: lithium hydroxide / water; tetrahydrofuran; methanol / 2 h / 65 °C View Scheme |
N-benzyl-2-(2-(bis(2-hydroxyethyl)amino)ethoxy)acetamide
levocetirizine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride / dichloromethane / 0 - 20 °C / Inert atmosphere 2.1: N-ethyl-N,N-diisopropylamine / 4 h / 130 °C / Inert atmosphere 3.1: sulfuric acid / methanol / 16 h / Reflux 3.2: 2 h / pH 10 - 12 3.3: pH 4.5 View Scheme |
Conditions | Yield |
---|---|
With CHIRALPAK human serum albumin (HSA) column In aq. phosphate buffer; isopropyl alcohol at 25℃; pH=7; Solvent; Concentration; Temperature; Resolution of racemate; |
levocetirizine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: tetrahydrofuran 2.1: dimethylsulfide borane complex / tetrahydrofuran / Reflux 3.1: water; potassium hydroxide / methanol / 1 h / 80 °C 3.2: pH 4 - 4.5 View Scheme |
R-2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)-2-oxoethoxy)acetic acid
levocetirizine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: oxalyl dichloride / tetrahydrofuran / 0 - 5 °C 2.1: tetrahydrofuran 3.1: dimethylsulfide borane complex / tetrahydrofuran / Reflux 4.1: water; potassium hydroxide / methanol / 1 h / 80 °C 4.2: pH 4 - 4.5 View Scheme |
R-methyl 2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)-2-oxoethoxy)acetate
levocetirizine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: dimethylsulfide borane complex / tetrahydrofuran / Reflux 2.1: water; potassium hydroxide / methanol / 1 h / 80 °C 2.2: pH 4 - 4.5 View Scheme |
triethanolamine
levocetirizine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: thionyl chloride / dichloromethane / 3 h / 38 - 42 °C 2: N-ethyl-N,N-diisopropylamine / 3 h / 120 °C 3: sodium hydride; sodium iodide / N,N-dimethyl-formamide; acetone / 3 h / 25 °C 4: lithium hydroxide / water; tetrahydrofuran; methanol / 2 h / 65 °C View Scheme |
tris-(2-chloro-ethyl)-amine
levocetirizine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine / 3 h / 120 °C 2: sodium hydride; sodium iodide / N,N-dimethyl-formamide; acetone / 3 h / 25 °C 3: lithium hydroxide / water; tetrahydrofuran; methanol / 2 h / 65 °C View Scheme |
4-chlorobenzophenone
levocetirizine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: formamide / 170 - 175 °C / Inert atmosphere 2: L-Tartaric acid / 30 - 90 °C / Inert atmosphere 3: N-ethyl-N,N-diisopropylamine / 3 h / 120 °C 4: sodium hydride; sodium iodide / N,N-dimethyl-formamide; acetone / 3 h / 25 °C 5: lithium hydroxide / water; tetrahydrofuran; methanol / 2 h / 65 °C View Scheme |
triphenyltin(IV) hydroxide
levocetirizine
Conditions | Yield |
---|---|
With sulfuric acid In ethanol; acetone Reflux; | 71% |
Conditions | Yield |
---|---|
In acetone at 40 - 50℃; | |
In water; acetone at 20 - 35℃; for 0.166667 - 0.5h; |
levocetirizine
Conditions | Yield |
---|---|
With hydrogenchloride In acetone at 55℃; | |
With hydrogenchloride In acetone at 0 - 30℃; for 4h; pH=1.0 - 2.0; | |
Stage #1: levocetirizine With hydrogenchloride In water; acetone at 20℃; for 0.166667 - 0.5h; Stage #2: In cyclohexane at 30 - 35℃; for 0.5h; | |
Stage #1: levocetirizine In ethyl acetate at 25 - 35℃; for 0.166667 - 0.25h; Stage #2: With hydrogenchloride In isopropyl alcohol pH=2; Stage #3: for 1 - 2h; | |
With hydrogenchloride In water; acetone at 25 - 30℃; for 12h; |
levocetirizine
Conditions | Yield |
---|---|
In methanol; water at 130℃; for 30.3333h; Temperature; | 2.3 g |
Conditions | Yield |
---|---|
In methanol at 25℃; |
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