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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Levocetirizine Manufacturer/High quality/Best price/In stock

Cas:130018-77-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Alerlisin supplier in China

Cas:130018-77-8

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Alerlisin

Cas:130018-77-8

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Levocetirizine 130018-77-8 GMP manufacturer

Cas:130018-77-8

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(+)-Cetirizine

Cas:130018-77-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Levocetirizine

Cas:130018-77-8

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

High quality CAS 130018-77-8 with best quality

Cas:130018-77-8

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Levocetirizine/ LIDE PHARMA- Factory supply / Best price

Cas:130018-77-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Product Name Levocetirizine CAS 130018-77-8 Molecular formula C21H27Cl3N2O3 Molecular weight 461.8097 Appearance:White powder St

Levocetirizine

Cas:130018-77-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Levocetirizine 130018-77-8

Cas:130018-77-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: Levocetirizine Synonyms: LEVOCETIRIZINE;alerlisin;2-[2-[4-[(R)-(4-chlorophenyl)-phenylmethyl]-1-piperazinyl]ethoxy]acetic acid;Cetirizine Impurity 20;(R)-2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetic acid;LE

Levocetirizine

Cas:130018-77-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Levocetirizine CAS:130018-77-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermedi

Levocetirizine CAS:130018-77-8

Cas:130018-77-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Levocetirizine

Cas:130018-77-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Levocetirizine

Cas:130018-77-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Top quality Levocetirizine99.5%min

Cas:130018-77-8

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Levocetirizine

Cas:130018-77-8

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Levocetirizine

Cas:130018-77-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Levocetirizine

Cas:130018-77-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hebei Kunsui Technology Co., Ltd.

1. A strong scientific research team . 2. Stable quality (with a complete scientific research center and testing center to ensure the quality stability of each batch of products). 3. Rich export experience (with practical experience in exporting to m

Pharmaceutical Levocetirizine Powder CAS 130018-77-8

Cas:130018-77-8

Min.Order:1 Kilogram

FOB Price: $8.2 / 8.8

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Levocetirizine

Cas:130018-77-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Levocetirizine

Cas:130018-77-8

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Levocetirizine

Cas:130018-77-8

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Siwei Development Group Ltd.

Product name:Levocetirizine HCL CAS No.:130018-77-8 Molecule Formula:C21H27Cl3N2O3 Molecule Weight:461.80 Purity: 98.5% Package: 25kg/drum Description:White crystals powder Manufacture Standards:Enterprise Standard

Lower Price Levocetirizine HCL

Cas:130018-77-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Levocetirizine

Cas:130018-77-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Levocetirizine

Cas:130018-77-8

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFU-CHEM CAS NO.130018-77-8 Levocetirizine

Cas:130018-77-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Levocetirizine

Cas:130018-77-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:Active Pharmaceutical I

Levocetirizine

Cas:130018-77-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Levocetirizine

Cas:130018-77-8

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

Levocetirizine

Cas:130018-77-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

C23H29ClN2O3

C23H29ClN2O3

levocetirizine
130018-77-8

levocetirizine

Conditions
ConditionsYield
With lithium hydroxide In tetrahydrofuran; methanol; water at 65℃; for 2h;90%
(2-chloroethoxy)-acetic acid
14869-41-1

(2-chloroethoxy)-acetic acid

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

levocetirizine
130018-77-8

levocetirizine

Conditions
ConditionsYield
With tetrabutylammomium bromide; sodium hydride In N,N-dimethyl-formamide at 95℃; for 5h; Inert atmosphere;86.5%
(R)-(2-{4-[(4-chlorophenyl)phenylmethyl]piperazin-1-yl}ethoxy)acetic acid methyl ester

(R)-(2-{4-[(4-chlorophenyl)phenylmethyl]piperazin-1-yl}ethoxy)acetic acid methyl ester

levocetirizine
130018-77-8

levocetirizine

Conditions
ConditionsYield
With hydrogenchloride In water Large scale; enantioselective reaction;74%
Stage #1: (R)-(2-{4-[(4-chlorophenyl)phenylmethyl]piperazin-1-yl}ethoxy)acetic acid methyl ester With water; potassium hydroxide In methanol at 80℃; for 1h;
Stage #2: With hydrogenchloride In dichloromethane; water pH=4 - 4.5; Product distribution / selectivity;
levocetirizine N-benzyl amide
1150310-68-1

levocetirizine N-benzyl amide

levocetirizine
130018-77-8

levocetirizine

Conditions
ConditionsYield
Stage #1: levocetirizine N-benzyl amide With sulfuric acid In methanol for 16h; Reflux;
Stage #2: With sodium hydroxide In methanol for 2h; pH=10 - 12;
Stage #3: With hydrogenchloride In methanol; water pH=4.5;
70%
Stage #1: levocetirizine N-benzyl amide With sulfuric acid; water at 80 - 85℃; for 8h;
Stage #2: With sodium hydroxide In water pH=4.0 - 4.5;
n/a
(R)-2-(2-{4-[(4-chlorophenyl)phenylmethyl]piperazin-1-yl}ethoxy)acetamide
909779-33-5

(R)-2-(2-{4-[(4-chlorophenyl)phenylmethyl]piperazin-1-yl}ethoxy)acetamide

levocetirizine
130018-77-8

levocetirizine

Conditions
ConditionsYield
With hydrogenchloride In water at 65℃; for 4h;
Multi-step reaction with 2 steps
1.1: hydrogenchloride / methanol / 4 h / Reflux
1.2: 7 h
2.1: hydrogenchloride / water / Large scale
View Scheme
(+)-[2-[4-[(4-chlorophenyl)-phenyl methyl]-1-piperazinyl]]ethanol
705289-61-8

(+)-[2-[4-[(4-chlorophenyl)-phenyl methyl]-1-piperazinyl]]ethanol

sodium monochloroacetic acid
3926-62-3

sodium monochloroacetic acid

levocetirizine
130018-77-8

levocetirizine

Conditions
ConditionsYield
Stage #1: (+)-[2-[4-[(4-chlorophenyl)-phenyl methyl]-1-piperazinyl]]ethanol With potassium hydroxide In N,N-dimethyl-formamide at 0 - 5℃; for 1.5h;
Stage #2: sodium monochloroacetic acid at 0 - 5℃; for 1.5h;
Stage #3: at 30 - 35℃;
Stage #1: (+)-[2-[4-[(4-chlorophenyl)-phenyl methyl]-1-piperazinyl]]ethanol With potassium hydroxide In DMF (N,N-dimethyl-formamide) at 0 - 5℃; for 1.5h;
Stage #2: sodium monochloroacetic acid In DMF (N,N-dimethyl-formamide) at 0 - 35℃;
Stage #3: With hydrogenchloride In DMF (N,N-dimethyl-formamide); water pH=4 - 4.5;
(R)-2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-1-(S)-[N-(1-phenyIethyl)]acetamide
1150310-67-0

(R)-2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-1-(S)-[N-(1-phenyIethyl)]acetamide

levocetirizine
130018-77-8

levocetirizine

Conditions
ConditionsYield
With water; hydrogen bromide at 90 - 95℃; for 24h; Product distribution / selectivity;
Stage #1: (R)-2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-1-(S)-[N-(1-phenyIethyl)]acetamide With sulfuric acid; water at 80 - 85℃; for 48h;
Stage #2: With sodium hydroxide In water pH=4.5 - 5.0; Product distribution / selectivity;
cetirizine
83881-51-0

cetirizine

A

(S)-cetirizine

(S)-cetirizine

B

levocetirizine
130018-77-8

levocetirizine

Conditions
ConditionsYield
Resolution of racemate;
With N,N-diethylaniline In hexane; isopropyl alcohol at 25℃; Reagent/catalyst; Resolution of racemate;
With maltodextrin In aq. buffer at 25℃; pH=3; Reagent/catalyst; pH-value; Temperature; Resolution of racemate;
C19H23ClN2O*ClH

C19H23ClN2O*ClH

sodium monochloroacetic acid
3926-62-3

sodium monochloroacetic acid

levocetirizine
130018-77-8

levocetirizine

Conditions
ConditionsYield
Stage #1: C19H23ClN2O*ClH With ammonia In water; toluene for 0.25h; pH=8.5 - 9;
Stage #2: sodium monochloroacetic acid With potassium hydroxide In N,N-dimethyl-formamide at 0 - 10℃;
Stage #3: With hydrogenchloride In dichloromethane; water pH=4.3 - 4.8;
(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

levocetirizine
130018-77-8

levocetirizine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triethylamine / toluene / 7 h / 110 - 115 °C
1.2: 12 h / 25 - 30 °C
2.1: ammonia / toluene; water / 0.25 h / pH 8.5 - 9
2.2: 0 - 10 °C
2.3: pH 4.3 - 4.8
View Scheme
Multi-step reaction with 5 steps
1.1: tetrabutylammomium bromide / dimethyl sulfoxide / 10 h
2.1: oxalyl dichloride / tetrahydrofuran / 0 - 5 °C
3.1: tetrahydrofuran
4.1: dimethylsulfide borane complex / tetrahydrofuran / Reflux
5.1: water; potassium hydroxide / methanol / 1 h / 80 °C
5.2: pH 4 - 4.5
View Scheme
(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

levocetirizine
130018-77-8

levocetirizine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: N-ethyl-N,N-diisopropylamine / 128 - 130 °C
2.1: potassium hydroxide / isopropyl alcohol / 9 h / 80 - 85 °C
3.1: triethylamine / toluene / 7 h / 110 - 115 °C
3.2: 12 h / 25 - 30 °C
4.1: ammonia / toluene; water / 0.25 h / pH 8.5 - 9
4.2: 0 - 10 °C
4.3: pH 4.3 - 4.8
View Scheme
Multi-step reaction with 6 steps
1.1: N-ethyl-N,N-diisopropylamine / 3 h / Reflux
1.2: 60 °C / Reflux
2.1: tetrabutylammomium bromide / dimethyl sulfoxide / 10 h
3.1: oxalyl dichloride / tetrahydrofuran / 0 - 5 °C
4.1: tetrahydrofuran
5.1: dimethylsulfide borane complex / tetrahydrofuran / Reflux
6.1: water; potassium hydroxide / methanol / 1 h / 80 °C
6.2: pH 4 - 4.5
View Scheme
Multi-step reaction with 3 steps
1: N-ethyl-N,N-diisopropylamine / 3 h / 120 °C
2: sodium hydride; sodium iodide / N,N-dimethyl-formamide; acetone / 3 h / 25 °C
3: lithium hydroxide / water; tetrahydrofuran; methanol / 2 h / 65 °C
View Scheme
C2H2O4*C17H19ClN2

C2H2O4*C17H19ClN2

levocetirizine
130018-77-8

levocetirizine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydroxide / water / 0.5 h / 65 - 70 °C
2.1: triethylamine / toluene / 7 h / 110 - 115 °C
2.2: 12 h / 25 - 30 °C
3.1: ammonia / toluene; water / 0.25 h / pH 8.5 - 9
3.2: 0 - 10 °C
3.3: pH 4.3 - 4.8
View Scheme
C22H27ClN2O2
1391851-21-0

C22H27ClN2O2

levocetirizine
130018-77-8

levocetirizine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium hydroxide / isopropyl alcohol / 9 h / 80 - 85 °C
2.1: triethylamine / toluene / 7 h / 110 - 115 °C
2.2: 12 h / 25 - 30 °C
3.1: ammonia / toluene; water / 0.25 h / pH 8.5 - 9
3.2: 0 - 10 °C
3.3: pH 4.3 - 4.8
View Scheme
N-benzyl-2-(2-(bis(2-chloroethyl)amino)ethoxy)acetamide
1150310-73-8

N-benzyl-2-(2-(bis(2-chloroethyl)amino)ethoxy)acetamide

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

levocetirizine
130018-77-8

levocetirizine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: N-ethyl-N,N-diisopropylamine / 4 h / 130 °C / Inert atmosphere
2.1: sulfuric acid / methanol / 16 h / Reflux
2.2: 2 h / pH 10 - 12
2.3: pH 4.5
View Scheme
p-chlorobenzhydrylamine
28022-43-7

p-chlorobenzhydrylamine

levocetirizine
130018-77-8

levocetirizine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydrogenchloride; borane-ammonia complex / aq. phosphate buffer / 37 °C / pH 7.8
2.1: N-ethyl-N,N-diisopropylamine / 4 h / 130 °C / Inert atmosphere
3.1: sulfuric acid / methanol / 16 h / Reflux
3.2: 2 h / pH 10 - 12
3.3: pH 4.5
View Scheme
Multi-step reaction with 4 steps
1: L-Tartaric acid / 30 - 90 °C / Inert atmosphere
2: N-ethyl-N,N-diisopropylamine / 3 h / 120 °C
3: sodium hydride; sodium iodide / N,N-dimethyl-formamide; acetone / 3 h / 25 °C
4: lithium hydroxide / water; tetrahydrofuran; methanol / 2 h / 65 °C
View Scheme
N-benzyl-2-(2-(bis(2-hydroxyethyl)amino)ethoxy)acetamide
1150310-72-7

N-benzyl-2-(2-(bis(2-hydroxyethyl)amino)ethoxy)acetamide

levocetirizine
130018-77-8

levocetirizine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride / dichloromethane / 0 - 20 °C / Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine / 4 h / 130 °C / Inert atmosphere
3.1: sulfuric acid / methanol / 16 h / Reflux
3.2: 2 h / pH 10 - 12
3.3: pH 4.5
View Scheme
cetirizine dihydrochloride
83881-52-1

cetirizine dihydrochloride

A

(S)-cetirizine

(S)-cetirizine

B

levocetirizine
130018-77-8

levocetirizine

Conditions
ConditionsYield
With CHIRALPAK human serum albumin (HSA) column In aq. phosphate buffer; isopropyl alcohol at 25℃; pH=7; Solvent; Concentration; Temperature; Resolution of racemate;
R-2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)-2-oxoethoxy)acetyl chloride

R-2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)-2-oxoethoxy)acetyl chloride

levocetirizine
130018-77-8

levocetirizine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: tetrahydrofuran
2.1: dimethylsulfide borane complex / tetrahydrofuran / Reflux
3.1: water; potassium hydroxide / methanol / 1 h / 80 °C
3.2: pH 4 - 4.5
View Scheme
R-2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)-2-oxoethoxy)acetic acid
1058165-14-2

R-2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)-2-oxoethoxy)acetic acid

levocetirizine
130018-77-8

levocetirizine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: oxalyl dichloride / tetrahydrofuran / 0 - 5 °C
2.1: tetrahydrofuran
3.1: dimethylsulfide borane complex / tetrahydrofuran / Reflux
4.1: water; potassium hydroxide / methanol / 1 h / 80 °C
4.2: pH 4 - 4.5
View Scheme
R-methyl 2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)-2-oxoethoxy)acetate
1201648-47-6

R-methyl 2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)-2-oxoethoxy)acetate

levocetirizine
130018-77-8

levocetirizine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: dimethylsulfide borane complex / tetrahydrofuran / Reflux
2.1: water; potassium hydroxide / methanol / 1 h / 80 °C
2.2: pH 4 - 4.5
View Scheme
triethanolamine
102-71-6

triethanolamine

levocetirizine
130018-77-8

levocetirizine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: thionyl chloride / dichloromethane / 3 h / 38 - 42 °C
2: N-ethyl-N,N-diisopropylamine / 3 h / 120 °C
3: sodium hydride; sodium iodide / N,N-dimethyl-formamide; acetone / 3 h / 25 °C
4: lithium hydroxide / water; tetrahydrofuran; methanol / 2 h / 65 °C
View Scheme
tris-(2-chloro-ethyl)-amine
555-77-1

tris-(2-chloro-ethyl)-amine

levocetirizine
130018-77-8

levocetirizine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N-ethyl-N,N-diisopropylamine / 3 h / 120 °C
2: sodium hydride; sodium iodide / N,N-dimethyl-formamide; acetone / 3 h / 25 °C
3: lithium hydroxide / water; tetrahydrofuran; methanol / 2 h / 65 °C
View Scheme
4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

levocetirizine
130018-77-8

levocetirizine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: formamide / 170 - 175 °C / Inert atmosphere
2: L-Tartaric acid / 30 - 90 °C / Inert atmosphere
3: N-ethyl-N,N-diisopropylamine / 3 h / 120 °C
4: sodium hydride; sodium iodide / N,N-dimethyl-formamide; acetone / 3 h / 25 °C
5: lithium hydroxide / water; tetrahydrofuran; methanol / 2 h / 65 °C
View Scheme
triphenyltin(IV) hydroxide
76-87-9

triphenyltin(IV) hydroxide

levocetirizine
130018-77-8

levocetirizine

(R)-triphenylstannyl 2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy) acetate

(R)-triphenylstannyl 2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy) acetate

Conditions
ConditionsYield
With sulfuric acid In ethanol; acetone Reflux;71%
hydrogenchloride
7647-01-0

hydrogenchloride

levocetirizine
130018-77-8

levocetirizine

(+)-Cetirizine dihydrochloride

(+)-Cetirizine dihydrochloride

Conditions
ConditionsYield
In acetone at 40 - 50℃;
In water; acetone at 20 - 35℃; for 0.166667 - 0.5h;
levocetirizine
130018-77-8

levocetirizine

levocetirizine dihydrochloride

levocetirizine dihydrochloride

Conditions
ConditionsYield
With hydrogenchloride In acetone at 55℃;
With hydrogenchloride In acetone at 0 - 30℃; for 4h; pH=1.0 - 2.0;
Stage #1: levocetirizine With hydrogenchloride In water; acetone at 20℃; for 0.166667 - 0.5h;
Stage #2: In cyclohexane at 30 - 35℃; for 0.5h;
Stage #1: levocetirizine In ethyl acetate at 25 - 35℃; for 0.166667 - 0.25h;
Stage #2: With hydrogenchloride In isopropyl alcohol pH=2;
Stage #3: for 1 - 2h;
With hydrogenchloride In water; acetone at 25 - 30℃; for 12h;
levocetirizine
130018-77-8

levocetirizine

C21H23ClN2O3

C21H23ClN2O3

Conditions
ConditionsYield
In methanol; water at 130℃; for 30.3333h; Temperature;2.3 g
curcumin
458-37-7

curcumin

levocetirizine
130018-77-8

levocetirizine

C21H25ClN2O3*C21H20O6

C21H25ClN2O3*C21H20O6

Conditions
ConditionsYield
In methanol at 25℃;

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