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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

(-)-1-[(4-Chlorophenyl)phenylmethyl]piperazine Manufacturer/High quality/Best price/In stock

Cas:300543-56-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality (-)-1-[(4-Chlorophenyl)Phenylmethyl]Piperazine supplier in China

Cas:300543-56-0

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply (-)-(R)-1-((4-Chlorophenyl)(phenyl)methyl)piperazine

Cas:300543-56-0

Min.Order:1

Negotiable

Type:Other

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(R)-1-(p-Chlorobenzhydryl)-piperazine

Cas:300543-56-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

(-)-1-[(4-Chlorophenyl)Phenylmethyl]Piperazine/ LIDE PHARMA- Factory supply / Best price

Cas:300543-56-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine

Cas:300543-56-0

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

(-)-1-[(4-Chlorophenyl)phenylmethyl]piperazine 300543-56-0

Cas:300543-56-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine CAS:300543-56-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing

(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine CAS:300543-56-0

Cas:300543-56-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

(-)-1-[(4-Chlorophenyl)phenylmethyl]piperazine

Cas:300543-56-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

(-)-1-[(4-Chlorophenyl)phenylmethyl]piperazine

Cas:300543-56-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

(-)-1-[(4-Chlorophenyl)phenylmethyl]piperazine

Cas:300543-56-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

TIANFUCHEM--(-)-1-[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE

Cas:300543-56-0

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(-)-1-[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE

Cas:300543-56-0

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

(-)-1-[(4-Chlorophenyl)phenylmethyl]piperazine

Cas:300543-56-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality (-)-1-[(4-Chlorophenyl)Phenylmethyl]Piperazine

Cas:300543-56-0

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

(-)-1-[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE Basic information Product Name: (-)-1-[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE Synonyms: (-)-1-[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE;(R)-(-)-1-[(4-Chlorophenyl)phenylmeth

TIANFUCHEM--(-)-1-[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE

Cas:300543-56-0

Min.Order:1 Metric Ton

FOB Price: $20.0

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: (R)-(-)-1-[(4-Chlorophenyl)phenmethyl]piperazine CAS No.:300543-56-0 Molecule Formula:C17H19ClN2 Molecule Weight:286.80 Purity: 99.0% Package: 25kg/drum Description:White or almost white crystalline powder Manufacture St

High Quality (R)-(-)-1-[(4-Chlorophenyl)phenmethyl]piperazine

Cas:300543-56-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine

Cas:300543-56-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

TIANFUCHEM--(-)-1-[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE

Cas:300543-56-0

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

TIANFUCHEM--(-)-1-[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE

Cas:300543-56-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

TIANFUCHEM--(-)-1-[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE

Cas:300543-56-0

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in

SAGECHEM/ (R)-1-[(4-Chlorophenyl)phenylMethyl]piperazine /Manufacturer in China

Cas:300543-56-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Business Custom Synthesis:

(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine

Cas:300543-56-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:stored in a cool, dry and ventilated place to provent sun and rain Package:25kg/drum, or as per your request. Application:Used as Pharmaceutical Intermediate

(-)-1-[(4-Chlorophenyl)phenylmethyl]piperazine

Cas:300543-56-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

TIANFUCHEM--(-)-1-[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE

Cas:300543-56-0

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Hebei Mojin Biotechnology Co.,Ltd

1, High quality with competitive price:2, Fast and safe delivery3.Excellent pre-sales and after-sales service4. Well-trained and professional technologist and sales with rich experience in the field for 5-10 yearsAppearance:see detailed specification

Piperazine,1-[(R)-(4-chlorophenyl)phenylmethyl]-

Cas:300543-56-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

(R)-(-)-1-[(4-chlorophenyl)phenylmethyl]piperazine

Cas:300543-56-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

(-)-1-[(4-Chlorophenyl)Phenylmethyl]Piperazine

Cas:300543-56-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

BOC Sciences

BOC Sciences is committed to supplying cost-effective products and services. We provide Levocetirizine Impurity 2. Intermediate in the production of (R)-Cetirizine More information please visit: www.bocsci.com/levocetirizine-impurity-2-cas-300543-5

Levocetirizine Impurity 2

Cas:300543-56-0

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

(-)-1-[(4-Chlorophenyl)phenylmethyl]piperazine

Cas:300543-56-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

(R)-(-)-1-[(4-chlorophenyl)phenylmethyl]piperazine N-acetyl-L-phenylalanine salt
1161573-31-4

(R)-(-)-1-[(4-chlorophenyl)phenylmethyl]piperazine N-acetyl-L-phenylalanine salt

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

Conditions
ConditionsYield
With sodium hydroxide; water at 20℃; for 12.5h; Product distribution / selectivity;99%
With sodium hydroxide; water In ethyl acetate Product distribution / selectivity;90%
(-)-1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methoxyphenyl)sulfonyl]piperazine
943987-59-5

(-)-1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methoxyphenyl)sulfonyl]piperazine

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

Conditions
ConditionsYield
Stage #1: (-)-1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methoxyphenyl)sulfonyl]piperazine With hydrogen bromide; acetic acid at 70 - 75℃; for 3h; Industry scale;
Stage #2: With sodium hydroxide In water at 0 - 35℃; pH=~ 12 - ~ 14; Product distribution / selectivity; Industry scale;
92.7%
(-)-1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl)sulfonyl]piperazine
942283-97-8

(-)-1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl)sulfonyl]piperazine

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

Conditions
ConditionsYield
Stage #1: (-)-1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl)sulfonyl]piperazine With hydrogen bromide; acetic acid; 4-hydroxy-benzoic acid at 25℃; for 17h;
Stage #2: With sodium hydroxide In water Product distribution / selectivity;
84.8%
bis-(2-chloroethyl)amine hydrochloride
821-48-7

bis-(2-chloroethyl)amine hydrochloride

(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

Conditions
ConditionsYield
Stage #1: bis-(2-chloroethyl)amine hydrochloride; (R)-(4-chlorophenyl)(phenyl)methylamine With N-ethyl-N,N-diisopropylamine for 3h; Heating / reflux;
Stage #2: With diethylamine at 60℃; for 5h; Heating / reflux;
Stage #3: With sodium hydroxide; water pH=10 - 11;
Stage #1: bis-(2-chloroethyl)amine hydrochloride; (R)-(4-chlorophenyl)(phenyl)methylamine With N-ethyl-N,N-diisopropylamine for 3h; Reflux;
Stage #2: With diethylamine at 60℃; Reflux;
(R)-(+)-4-(4-chlorophenyl)-phenylmethyl-piperazine-1-carboxylic acid-2,2,2-trichloroethylester
941576-99-4

(R)-(+)-4-(4-chlorophenyl)-phenylmethyl-piperazine-1-carboxylic acid-2,2,2-trichloroethylester

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

Conditions
ConditionsYield
With sodium hydroxide; water In isopropyl alcohol at 20 - 100℃; Product distribution / selectivity;
C24H23ClN2O2
1136010-90-6

C24H23ClN2O2

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

Conditions
ConditionsYield
With sodium hydroxide; water In isopropyl alcohol for 3 - 3.5h; Product distribution / selectivity; Heating / reflux;n/a
C25H25ClN2O2
1155402-57-5

C25H25ClN2O2

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

Conditions
ConditionsYield
With sodium hydroxide; water In isopropyl alcohol for 1.5h; Product distribution / selectivity; Heating / reflux;
C25H25ClN2O3
1155402-66-6

C25H25ClN2O3

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

Conditions
ConditionsYield
With sodium hydroxide; water In isopropyl alcohol for 2.75h; Product distribution / selectivity; Heating / reflux;
C24H22ClN3O4
1155402-68-8

C24H22ClN3O4

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

Conditions
ConditionsYield
With sodium hydroxide; water In isopropyl alcohol at 50℃; for 3.5h; Product distribution / selectivity;
C25H25ClN2O2
1136010-92-8

C25H25ClN2O2

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

Conditions
ConditionsYield
With sodium hydroxide; water In isopropyl alcohol at 100℃; for 5h; Product distribution / selectivity;
(-)-1-[(4-chlorophenyl)phenylmethyl]-4-[(phenyl)sulfonyl]piperazine
1092460-01-9

(-)-1-[(4-chlorophenyl)phenylmethyl]-4-[(phenyl)sulfonyl]piperazine

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

Conditions
ConditionsYield
Stage #1: (-)-1-[(4-chlorophenyl)phenylmethyl]-4-[(phenyl)sulfonyl]piperazine With hydrogen bromide; acetic acid at 25 - 60℃; for 5h;
Stage #2: With water; sodium hydroxide In toluene
C28H37ClN2O2*H2O4S
1228582-98-6

C28H37ClN2O2*H2O4S

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

Conditions
ConditionsYield
Stage #1: C28H37ClN2O2*H2O4S With sulfuric acid In isopropyl alcohol at 20 - 90℃;
Stage #2: With sodium hydroxide In di-isopropyl ether; water; isopropyl alcohol
C28H37ClN2O2*(x)H2O4S

C28H37ClN2O2*(x)H2O4S

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

Conditions
ConditionsYield
Stage #1: C28H37ClN2O2*(x)H2O4S With sulfuric acid; isopropyl alcohol at 20 - 90℃;
Stage #2: With sodium hydroxide In water pH=8;
(R)-(4-chlorophenyl)(phenyl)methylamine
163837-57-8

(R)-(4-chlorophenyl)(phenyl)methylamine

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine / 128 - 130 °C
2: potassium hydroxide / isopropyl alcohol / 9 h / 80 - 85 °C
View Scheme
C2H2O4*C17H19ClN2

C2H2O4*C17H19ClN2

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

Conditions
ConditionsYield
With sodium hydroxide In water at 65 - 70℃; for 0.5h;
C22H27ClN2O2
1391851-21-0

C22H27ClN2O2

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

Conditions
ConditionsYield
With potassium hydroxide In isopropyl alcohol at 80 - 85℃; for 9h;
1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl)sulfonyl]piperazine

1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl)sulfonyl]piperazine

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

Conditions
ConditionsYield
With hydrogen bromide; acetic acid In dichloromethane at 10℃; for 3h; Inert atmosphere;
2-chloroethyl cyanomethyl ether
31250-08-5

2-chloroethyl cyanomethyl ether

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinil]ethoxy]-acetonitrile dihydrochloride

[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinil]ethoxy]-acetonitrile dihydrochloride

Conditions
ConditionsYield
Stage #1: 2-chloroethyl cyanomethyl ether; (R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine With sodium carbonate; potassium iodide In acetonitrile at 110 - 115℃; for 20h;
Stage #2: With hydrogenchloride In acetonitrile for 0.333333h; pH=0.5 - 1;
95%
2-chloro-ethanol
107-07-3

2-chloro-ethanol

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

(+)-[2-[4-[(4-chlorophenyl)-phenyl methyl]-1-piperazinyl]]ethanol
705289-61-8

(+)-[2-[4-[(4-chlorophenyl)-phenyl methyl]-1-piperazinyl]]ethanol

Conditions
ConditionsYield
With triethylamine at 80 - 105℃; for 5.5 - 6h; Industry scale;90.49%
With sodium carbonate; potassium iodide In toluene for 24h; Reflux;
(2-chloroethoxy)-acetic acid
14869-41-1

(2-chloroethoxy)-acetic acid

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

levocetirizine
130018-77-8

levocetirizine

Conditions
ConditionsYield
With tetrabutylammomium bromide; sodium hydride In N,N-dimethyl-formamide at 95℃; for 5h; Inert atmosphere;86.5%
1,3-chlorobromopropane
109-70-6

1,3-chlorobromopropane

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

C20H24Cl2N2
942132-43-6

C20H24Cl2N2

Conditions
ConditionsYield
With triethylamine In toluene at 55℃;70%
tert-butyl-[4-(5-chloromethyl-tetrahydro-furan-2-yl)-but-3-ynyloxy]-dimethyl-silane

tert-butyl-[4-(5-chloromethyl-tetrahydro-furan-2-yl)-but-3-ynyloxy]-dimethyl-silane

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

A

1-{(2S,5S)-5-[4-(tert-Butyl-dimethyl-silanyloxy)-but-1-ynyl]-tetrahydro-furan-2-ylmethyl}-4-[(R)-(4-chloro-phenyl)-phenyl-methyl]-piperazine

1-{(2S,5S)-5-[4-(tert-Butyl-dimethyl-silanyloxy)-but-1-ynyl]-tetrahydro-furan-2-ylmethyl}-4-[(R)-(4-chloro-phenyl)-phenyl-methyl]-piperazine

B

1-{(2S,5R)-5-[4-(tert-Butyl-dimethyl-silanyloxy)-but-1-ynyl]-tetrahydro-furan-2-ylmethyl}-4-[(R)-(4-chloro-phenyl)-phenyl-methyl]-piperazine

1-{(2S,5R)-5-[4-(tert-Butyl-dimethyl-silanyloxy)-but-1-ynyl]-tetrahydro-furan-2-ylmethyl}-4-[(R)-(4-chloro-phenyl)-phenyl-methyl]-piperazine

Conditions
ConditionsYield
With potassium carbonate; sodium iodide In N,N-dimethyl-formamide; toluene Heating;A 36%
B n/a
oxalic acid
144-62-7

oxalic acid

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

C2H2O4*C17H19ClN2

C2H2O4*C17H19ClN2

Conditions
ConditionsYield
In ethanol at 5 - 20℃; Product distribution / selectivity;16.2%
In ethanol; ethyl acetate at 5 - 20℃; Product distribution / selectivity;n/a
In ethanol; ethyl acetate at 5 - 20℃; Product distribution / selectivity;n/a
In isopropyl alcohol at 80 - 85℃; for 0.5h;
C7H8N2O4

C7H8N2O4

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

C24H27ClN4O3

C24H27ClN4O3

Conditions
ConditionsYield
With sodium cyanoborohydride; acetic acid In methanol
C10H10N2O4

C10H10N2O4

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

C27H29ClN4O3

C27H29ClN4O3

Conditions
ConditionsYield
With sodium cyanoborohydride; acetic acid In methanol
C10H10N2O4
708263-47-2

C10H10N2O4

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

C27H29ClN4O3

C27H29ClN4O3

Conditions
ConditionsYield
With sodium cyanoborohydride; acetic acid In methanol
tert-butyl-[4-(5-chloromethyl-tetrahydro-furan-2-yl)-but-3-ynyloxy]-dimethyl-silane

tert-butyl-[4-(5-chloromethyl-tetrahydro-furan-2-yl)-but-3-ynyloxy]-dimethyl-silane

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

A

1-{(2R,5S)-5-[4-(tert-Butyl-dimethyl-silanyloxy)-but-1-ynyl]-tetrahydro-furan-2-ylmethyl}-4-[(R)-(4-chloro-phenyl)-phenyl-methyl]-piperazine

1-{(2R,5S)-5-[4-(tert-Butyl-dimethyl-silanyloxy)-but-1-ynyl]-tetrahydro-furan-2-ylmethyl}-4-[(R)-(4-chloro-phenyl)-phenyl-methyl]-piperazine

B

1-{(2R,5R)-5-[4-(tert-Butyl-dimethyl-silanyloxy)-but-1-ynyl]-tetrahydro-furan-2-ylmethyl}-4-[(R)-(4-chloro-phenyl)-phenyl-methyl]-piperazine

1-{(2R,5R)-5-[4-(tert-Butyl-dimethyl-silanyloxy)-but-1-ynyl]-tetrahydro-furan-2-ylmethyl}-4-[(R)-(4-chloro-phenyl)-phenyl-methyl]-piperazine

Conditions
ConditionsYield
With potassium carbonate; sodium iodide In N,N-dimethyl-formamide; toluene Heating;
(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

4-[4-(2-Bromoethoxy)phenyl]but-3-yn-1-ol
299461-25-9

4-[4-(2-Bromoethoxy)phenyl]but-3-yn-1-ol

4-[4-(2-{4-[(R)-(4-Chloro-phenyl)-phenyl-methyl]-piperazin-1-yl}-ethoxy)-phenyl]-but-3-yn-1-ol
299461-26-0

4-[4-(2-{4-[(R)-(4-Chloro-phenyl)-phenyl-methyl]-piperazin-1-yl}-ethoxy)-phenyl]-but-3-yn-1-ol

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide
(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

4-[4-(3-bromo-propoxy)-phenyl]-but-3-yn-1-ol
802982-14-5

4-[4-(3-bromo-propoxy)-phenyl]-but-3-yn-1-ol

4-[4-(3-{4-[(R)-(4-Chloro-phenyl)-phenyl-methyl]-piperazin-1-yl}-propoxy)-phenyl]-but-3-yn-1-ol
299461-37-3

4-[4-(3-{4-[(R)-(4-Chloro-phenyl)-phenyl-methyl]-piperazin-1-yl}-propoxy)-phenyl]-but-3-yn-1-ol

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide
(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

4-[4-(4-bromo-butoxy)-phenyl]-but-3-yn-1-ol
299461-39-5

4-[4-(4-bromo-butoxy)-phenyl]-but-3-yn-1-ol

4-[4-(4-{4-[(R)-(4-Chloro-phenyl)-phenyl-methyl]-piperazin-1-yl}-butoxy)-phenyl]-but-3-yn-1-ol

4-[4-(4-{4-[(R)-(4-Chloro-phenyl)-phenyl-methyl]-piperazin-1-yl}-butoxy)-phenyl]-but-3-yn-1-ol

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide
1,4-dioxane-2,6-dione
4480-83-5

1,4-dioxane-2,6-dione

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

R-2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)-2-oxoethoxy)acetic acid
1058165-14-2

R-2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)-2-oxoethoxy)acetic acid

Conditions
ConditionsYield
Stage #1: 1,4-dioxane-2,6-dione; (R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine In acetonitrile for 12h; Heating / reflux;
Stage #2: With sodium hydroxide; water In dichloromethane for 0.333333h;
Stage #3: In dichloromethane; water pH=4 - 4.5; Product distribution / selectivity; Acidic conditions;
Stage #1: 1,4-dioxane-2,6-dione; (R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine With tetrabutylammomium bromide In dimethyl sulfoxide for 10h;
Stage #2: With sodium hydroxide; water In Isopropyl acetate pH=10;
Stage #3: In Isopropyl acetate; water pH=4 - 4.5; Product distribution / selectivity; Acidic conditions;
With tetrabutylammomium bromide In dimethyl sulfoxide for 10h; Product distribution / selectivity;
1-Bromo-2-chloroethane
107-04-0

1-Bromo-2-chloroethane

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

C19H22Cl2N2

C19H22Cl2N2

Conditions
ConditionsYield
With triethylamine In toluene at 55℃;
(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

C28H30ClN5O2S2
1159975-50-4

C28H30ClN5O2S2

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / toluene / 55 °C
2: potassium carbonate; triethylamine / acetone / Reflux
View Scheme
(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
300543-56-0

(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine

C31H35ClN6O2S
1159975-51-5

C31H35ClN6O2S

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / toluene / 55 °C
2: potassium carbonate; triethylamine / acetone / Reflux
View Scheme

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