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Qingdao Beluga Import and Export Co., LTD

2-[4-[(E)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethyl-ethanamine CAS:13002-65-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediat

2-[4-[(E)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethyl-ethanamine CAS:13002-65-8

Cas:13002-65-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Ethanamine,2-[4-[(1E)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-

Cas:13002-65-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Ethanamine,2-[4-[(1E)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-

Cas:13002-65-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Ethanamine,2-[4-[(1E)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-

Cas:13002-65-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

2-[4-[(E)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine

Cas:13002-65-8

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

2-[4-[(E)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine

Cas:13002-65-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

2-[4-[(E)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine

Cas:13002-65-8

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

2-[4-[(E)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine

Cas:13002-65-8

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals

2-[4-[(E)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethyl-ethanamine

Cas:13002-65-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

2-[4-[(E)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethyl-ethanamine

Cas:13002-65-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

Ethanamine,2-[4-[(1E)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-

Cas:13002-65-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

2-[4-[(E)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethyl-ethanamine

Cas:13002-65-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Ethanamine,2-[4-[(1E)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-

Cas:13002-65-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

2-[4-[(E)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine Application:2-[4-[(E)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine

2-[4-[(E)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine

Cas:13002-65-8

Min.Order:0

Negotiable

Type:Other

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

Appearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

2-[4-[(E)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine CAS No.13002-65-8

Cas:13002-65-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

DB BIOTECH CO., LTD

best seller Application:API

2-[4-[(E)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethyl-ethanamine

Cas:13002-65-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

BOC Sciences

We are committed to providing our customers with the best products and services at the most competitive prices.Appearance:Powder Storage:Room temperature with sealed well Package:according to the clients requirement Application:Use as primary and sec

(E)-Tamoxifen

Cas:13002-65-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

2-[4-[(E)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethyl-ethanamine

Cas:13002-65-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hunan Longxianng Runhui Trading Co.,Ltd

2-[4-[(E)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamineAppearance:ASK Storage:Keep in dry and cool condition Package:foil aluminium bag/vacuum packing Application:intermediates Transportation:By express (Door to door) such as FEDEX, DHL, EMS

2-[4-[(E)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine

Cas:13002-65-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

13002-65-8

Cas:13002-65-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hebei Muhuang Technology Co., Ltd

best seller Application:API

2-[4-[(E)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethyl-ethanamine

Cas:13002-65-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

2-[4-[(E)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethyl-ethanamine

Cas:13002-65-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

suzhou BetterBioChem Co., Ltd.

Betterbiochem is specialized in APIs, pharmaceutical intermediates & fine chemicals. 1. The best quality, competitive price. 2. The best service before or after shipment. 3. Rich experience in export operation. 4. Rich experience in

2-[4-[(E)-1,2-DIPHENYLBUT-1-ENYL]PHENOXY]-N,N-DIMETHYL-ETHANAMINE

Cas:13002-65-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Nanjing Chemlin Chemical Co., Ltd.

Compound sourcing ServicesAgency of testing serviceFactory audit serviceFounded in Dec. 1999, Nanjing Chemlin Chemical Industrial Co.,Ltd(CHEMLIN) has been covering the business scope from trading of chemicals to custom-synthesis & Manufacturing. Co

13002-65-8

Cas:13002-65-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shandong Bolode Bio-Technology Co., LTD

Known for its best quality and competitve price, this chemicals we offered is widely appreciated by our customers. 1) All Purity≥95% 2) We are manufacturer and can provide high quality products with factory price. 2, Fast and s

Tamoxifen Citrate EP Impurity A

Cas:13002-65-8

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Shanghai united Scientific Co.,Ltd.

United Scientific Company Located in Shanghai of China , is a competitive player in the global specialty and fine chemical market. Fenghua has both the expertise and flexibility to produce a wide range of chemicals. Focusing on developing the innovat

Ethanamine,2-[4-[(1E)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-

Cas:13002-65-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Simson Pharma Limited

The system can just identify the products information in first sheet, it is not be permitted to add or edit new sheet by userself.Our products are required in MG to Gram only. · Pharmaceutical Reference Standards· Traceable workin

(E)-Tamoxifen (Ep imp A)

Cas:13002-65-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hubei Jusheng Technology Co., Ltd.,

1,Best Quality: Our products have exported to Germany, Spain, UK, USA, Australia, Middle East, and so on other countries, and we have got very good feedback from our customers.so

2-[4-[(E)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine

Cas:13002-65-8

Min.Order:10 Gram

FOB Price: $1.0 / 2.0

Type:Trading Company

inquiry

Shanghai Run-Biotech Co., Ltd.

Shanghai, Run-Biotech Co., Ltd is a leading domestic pharmaceutical, biopharmaceutical, and health care products R & D outsourcing services company. As an innovation-driven and customer-focused company, Run Biotech provides a broad and integrated por

2-[4-[(E)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethyl-ethanamine

Cas:13002-65-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

changchun tuocai technology co.,ltld

2-[4-[(E)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamineAppearance:ASK Storage:Keep in dry and cool condition Package:foil aluminium bag/vacuum packing Application:intermediates Transportation:by air or by sea

2-[4-[(E)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine

Cas:13002-65-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

ICI 77949
69967-79-9

ICI 77949

(2-chloroethyl)dimethylamine hydrochloride
4584-46-7

(2-chloroethyl)dimethylamine hydrochloride

(E)-tamoxifen
13002-65-8

(E)-tamoxifen

Conditions
ConditionsYield
With potassium carbonate In ethanol; toluene at 80 - 85℃; for 3h; Inert atmosphere;97%
With sodium ethanolate In ethanol for 24h; Heating;62%
With sodium hydride 1.) DMF, 2.) 60 deg C, 30 min; Yield given. Multistep reaction;
[2-(4-iodophenoxy)ethyl]dimethylamine
93790-54-6

[2-(4-iodophenoxy)ethyl]dimethylamine

(Z)-2-(1,2-diphenylbut-1-en-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
624731-39-1

(Z)-2-(1,2-diphenylbut-1-en-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

(E)-tamoxifen
13002-65-8

(E)-tamoxifen

Conditions
ConditionsYield
With sodium hydroxide; bis(tri-t-butylphosphine)palladium(0) In tetrahydrofuran at 60℃; for 24h; Suzuki-Miyaura coupling;95%
With sodium hydroxide; bis(tri-t-butylphosphine)palladium(0) In tetrahydrofuran at 60℃; for 24h; Suzuki-Miyaura coupling;95%
iodobenzene
591-50-4

iodobenzene

(Z)-1-(4',4',5',5'-tetramethyl-1',3',2'-dioxaborolan-2'-yl)-1-[4''-(2'''-dimethylaminoethoxy)phenyl]-2-phenyl-1-butene
865999-31-1

(Z)-1-(4',4',5',5'-tetramethyl-1',3',2'-dioxaborolan-2'-yl)-1-[4''-(2'''-dimethylaminoethoxy)phenyl]-2-phenyl-1-butene

(E)-tamoxifen
13002-65-8

(E)-tamoxifen

Conditions
ConditionsYield
With sodium hydroxide; bis(tri-t-butylphosphine)palladium(0) In tetrahydrofuran at 60℃; for 24h;75%
(E)-1,2-diphenylbut-1-en-1-yl dimethylcarbamate

(E)-1,2-diphenylbut-1-en-1-yl dimethylcarbamate

(4-(2-(dimethylamino)ethoxy)phenyl)magnesium bromide
35258-27-6

(4-(2-(dimethylamino)ethoxy)phenyl)magnesium bromide

(E)-tamoxifen
13002-65-8

(E)-tamoxifen

Conditions
ConditionsYield
With N,N'-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene hydrochloride; palladium diacetate In tetrahydrofuran at 50℃; for 18h; Schlenk technique; Inert atmosphere; Sealed tube; stereoselective reaction;70%
(E)-1,2-diphenyl-1-butene boronic acid
918793-63-2

(E)-1,2-diphenyl-1-butene boronic acid

[2-(4-bromophenoxy)ethyl]dimethylamine
2474-07-9

[2-(4-bromophenoxy)ethyl]dimethylamine

A

1,2-diphenyl-butan-1-one
16282-16-9

1,2-diphenyl-butan-1-one

B

tamoxifen
10540-29-1

tamoxifen

C

(E)-tamoxifen
13002-65-8

(E)-tamoxifen

Conditions
ConditionsYield
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In 1,2-dimethoxyethane; water Suzuki-Miyaura cross-coupling; Heating;A n/a
B 65%
C n/a
N,N-dimethyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)ethanamine
873078-93-4

N,N-dimethyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)ethanamine

(2R,3R)-2-ethyl-2,3-diphenyloxirane

(2R,3R)-2-ethyl-2,3-diphenyloxirane

(E)-tamoxifen
13002-65-8

(E)-tamoxifen

Conditions
ConditionsYield
Stage #1: (2R,3R)-2-ethyl-2,3-diphenyloxirane With N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium In diethyl ether; pentane at -78℃; for 0.25h;
Stage #2: N,N-dimethyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)ethanamine In diethyl ether at 20 - 38℃;
63%
2-(dimethylamino)ethyl chloride
107-99-3

2-(dimethylamino)ethyl chloride

(E,Z)-4-(1,2-diphenylbut-1-en-1-yl)phenol
68684-63-9

(E,Z)-4-(1,2-diphenylbut-1-en-1-yl)phenol

A

tamoxifen
10540-29-1

tamoxifen

B

(E)-tamoxifen
13002-65-8

(E)-tamoxifen

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 50℃; for 0.5h;A 51%
B 44%
With sodium hydride In N,N-dimethyl-formamide at 50℃; for 0.5h;
4-(4-[2-dimethylaminoethoxy]phenyl)-3,4-diphenylbut-1-ene

4-(4-[2-dimethylaminoethoxy]phenyl)-3,4-diphenylbut-1-ene

A

tamoxifen
10540-29-1

tamoxifen

B

(E)-tamoxifen
13002-65-8

(E)-tamoxifen

Conditions
ConditionsYield
With potassium tert-butylate In dimethyl sulfoxide at 20℃; for 1h;A 39%
B 37%
(1-phenylpropyl)phosphonic acid di-o-tolyl ester
872254-52-9

(1-phenylpropyl)phosphonic acid di-o-tolyl ester

(4-(2-(dimethylamino)ethoxy)phenyl)(phenyl)methanone
51777-15-2

(4-(2-(dimethylamino)ethoxy)phenyl)(phenyl)methanone

A

tamoxifen
10540-29-1

tamoxifen

B

(E)-tamoxifen
13002-65-8

(E)-tamoxifen

Conditions
ConditionsYield
Stage #1: (1-phenylpropyl)phosphonic acid di-o-tolyl ester With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h;
Stage #2: (4-(2-(dimethylamino)ethoxy)phenyl)(phenyl)methanone In tetrahydrofuran; hexane at -78℃; for 48h; Horner reaction;
A 28%
B 12%
tamoxifen
10540-29-1

tamoxifen

(E)-tamoxifen
13002-65-8

(E)-tamoxifen

Conditions
ConditionsYield
With hydrogenchloride In ethanol for 4h; Heating;
ICI 77949
69967-79-9

ICI 77949

(2-chloroethyl)dimethylamine hydrochloride
4584-46-7

(2-chloroethyl)dimethylamine hydrochloride

A

tamoxifen
10540-29-1

tamoxifen

B

(E)-tamoxifen
13002-65-8

(E)-tamoxifen

Conditions
ConditionsYield
With sodium methylate; hydrogen cation Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
(1S,2R)-1-[4-(2-Dimethylamino-ethoxy)-phenyl]-1,2-diphenyl-butan-1-ol
748-97-0, 77542-06-4, 77542-07-5, 81992-83-8, 111914-74-0

(1S,2R)-1-[4-(2-Dimethylamino-ethoxy)-phenyl]-1,2-diphenyl-butan-1-ol

A

tamoxifen
10540-29-1

tamoxifen

B

(E)-tamoxifen
13002-65-8

(E)-tamoxifen

Conditions
ConditionsYield
With hydrogenchloride In ethanol for 0.333333h; Heating; Yield given;
[2-(4-bromophenoxy)ethyl]dimethylamine
2474-07-9

[2-(4-bromophenoxy)ethyl]dimethylamine

triethylaluminum
97-93-8

triethylaluminum

diphenyl acetylene
501-65-5

diphenyl acetylene

(E)-tamoxifen
13002-65-8

(E)-tamoxifen

Conditions
ConditionsYield
tetrakis(triphenylphosphine) palladium(0) 1.) hexane, toluene, 90 deg C, 24 h, 2.) THF, reflux, 24 h; Yield given. Multistep reaction;
1-phenyl-1-butyne
622-76-4

1-phenyl-1-butyne

[2-(4-iodophenoxy)ethyl]dimethylamine
93790-54-6

[2-(4-iodophenoxy)ethyl]dimethylamine

p-I-C6H4-Si(Me2)CH2CH2CONH-resin

p-I-C6H4-Si(Me2)CH2CH2CONH-resin

A

tamoxifen
10540-29-1

tamoxifen

B

(E)-tamoxifen
13002-65-8

(E)-tamoxifen

C

{2-[4-(1-Benzhydrylidene-propyl)-phenoxy]-ethyl}-dimethyl-amine

{2-[4-(1-Benzhydrylidene-propyl)-phenoxy]-ethyl}-dimethyl-amine

Conditions
ConditionsYield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium hydroxide; 3,5-dimethoxyphenol; tetrakis(triphenylphosphine)platinum; trifluoroacetic acid; bis(pinacol)diborane 1.) DMF, 80 deg C, 2.) DME, 25 deg C, 18 h, 3.) 25 deg C, 18 h, 4.) CH2Cl2; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
1-phenyl-1-butyne
622-76-4

1-phenyl-1-butyne

4-tolyl iodide
624-31-7

4-tolyl iodide

p-I-C6H4-Si(Me2)CH2CH2CONH-resin

p-I-C6H4-Si(Me2)CH2CH2CONH-resin

A

(E)-tamoxifen
13002-65-8

(E)-tamoxifen

B

(Z)-(1-(p-tolyl)but-1-ene-1,2-diyl)dibenzene
116454-42-3

(Z)-(1-(p-tolyl)but-1-ene-1,2-diyl)dibenzene

C

{2-[4-(1-Benzhydrylidene-propyl)-phenoxy]-ethyl}-dimethyl-amine

{2-[4-(1-Benzhydrylidene-propyl)-phenoxy]-ethyl}-dimethyl-amine

Conditions
ConditionsYield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium hydroxide; 3,5-dimethoxyphenol; tetrakis(triphenylphosphine)platinum; trifluoroacetic acid; bis(pinacol)diborane 1.) DMF, 80 deg C, 2.) DME, 25 deg C, 18 h, 3.) 25 deg C, 18 h, 4.) CH2Cl2, 10 min; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
1-phenyl-1-butyne
622-76-4

1-phenyl-1-butyne

4-tolyl iodide
624-31-7

4-tolyl iodide

p-I-C6H4-Si(Me2)CH2CH2CONH-resin

p-I-C6H4-Si(Me2)CH2CH2CONH-resin

A

(E)-tamoxifen
13002-65-8

(E)-tamoxifen

B

C23H21I

C23H21I

C

{2-[4-(1-Benzhydrylidene-propyl)-phenoxy]-ethyl}-dimethyl-amine

{2-[4-(1-Benzhydrylidene-propyl)-phenoxy]-ethyl}-dimethyl-amine

Conditions
ConditionsYield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium hydroxide; 3,5-dimethoxyphenol; tetrakis(triphenylphosphine)platinum; Iodine monochloride; bis(pinacol)diborane 1.) DMF, 80 deg C, 2.) DME, 25 deg C, 18 h, 3.) 25 deg C, 18 h, 4.) CH2Cl2, 30 min; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
iodobenzene
591-50-4

iodobenzene

Z-(Et)(C6H5)CC(4-Me2NCH2CH2OC6H4)(B(pin))

Z-(Et)(C6H5)CC(4-Me2NCH2CH2OC6H4)(B(pin))

A

tamoxifen
10540-29-1

tamoxifen

B

(E)-tamoxifen
13002-65-8

(E)-tamoxifen

C

Dimethyl-{2-[4-((Z)-2-phenyl-but-1-enyl)-phenoxy]-ethyl}-amine

Dimethyl-{2-[4-((Z)-2-phenyl-but-1-enyl)-phenoxy]-ethyl}-amine

Conditions
ConditionsYield
With sodium hydroxide; bis(tri-t-butylphosphine)palladium(0) In tetrahydrofuran at 60℃; for 24h; Product distribution; Further Variations:; Reagents; Suzuki-Miyaura coupling;
(2-chloroethyl)dimethylamine hydrochloride
4584-46-7

(2-chloroethyl)dimethylamine hydrochloride

(E,Z)-4-(1,2-diphenylbut-1-en-1-yl)phenol
68684-63-9

(E,Z)-4-(1,2-diphenylbut-1-en-1-yl)phenol

A

tamoxifen
10540-29-1

tamoxifen

B

(E)-tamoxifen
13002-65-8

(E)-tamoxifen

Conditions
ConditionsYield
With sodium ethanolate In ethanol for 24h; Heating; Title compound not separated from byproducts;
Stage #1: 1-(4-hydroxyphenyl)-1,2-diphenylbut-1-ene With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃;
Stage #2: (2-chloroethyl)dimethylamine hydrochloride With potassium iodide In tetrahydrofuran; mineral oil for 12h; Reflux; Overall yield = 80 %; Overall yield = 148.5 mg; Optical yield = 8.108 %de;
diphenyl acetylene
501-65-5

diphenyl acetylene

(E)-tamoxifen
13002-65-8

(E)-tamoxifen

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: tetrahydrofuran; dibutyl ether / 2 h / -10 °C
1.2: 51 percent / triisopropyl borate / tetrahydrofuran; dibutyl ether / -78 - 20 °C
2.1: sodium carbonate / Pd(PPh3)4 / 1,2-dimethoxy-ethane; H2O / Heating
View Scheme
(1-(4-methoxyphenyl)but-1-ene-1,2-diyl)dibenzene
69967-78-8

(1-(4-methoxyphenyl)but-1-ene-1,2-diyl)dibenzene

ethanolic KOH

ethanolic KOH

(E)-tamoxifen
13002-65-8

(E)-tamoxifen

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: BBr3 / CH2Cl2 / 5 h / -60 - 20 °C
2: EtONa / ethanol / 24 h / Heating
View Scheme
1-((Z)-1,2-Diphenyl-buta-1,3-dienyl)-4-methoxy-benzene
857085-82-6

1-((Z)-1,2-Diphenyl-buta-1,3-dienyl)-4-methoxy-benzene

(E)-tamoxifen
13002-65-8

(E)-tamoxifen

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: aq. H2O2; N2H4*H2O / ethanol; CH2Cl2 / -60 - 20 °C
2: BBr3 / CH2Cl2 / 5 h / -60 - 20 °C
3: EtONa / ethanol / 24 h / Heating
View Scheme
1,1-bis(4',4',5',5'-tetramethyl-1',3',2'-dioxaborolan-2'-yl)-2-phenyl-1-butene
865999-18-4

1,1-bis(4',4',5',5'-tetramethyl-1',3',2'-dioxaborolan-2'-yl)-2-phenyl-1-butene

(E)-tamoxifen
13002-65-8

(E)-tamoxifen

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 55 percent / Pd2(dba)3; P(t-Bu)3; aq. KOH / tetrahydrofuran / 5 h / 20 °C
2: 75 percent / Pd[P(t-Bu)3]2; aq. NaOH / tetrahydrofuran / 24 h / 60 °C
View Scheme
[2-(4-iodophenoxy)ethyl]dimethylamine
93790-54-6

[2-(4-iodophenoxy)ethyl]dimethylamine

(E)-tamoxifen
13002-65-8

(E)-tamoxifen

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 55 percent / Pd2(dba)3; P(t-Bu)3; aq. KOH / tetrahydrofuran / 5 h / 20 °C
2: 75 percent / Pd[P(t-Bu)3]2; aq. NaOH / tetrahydrofuran / 24 h / 60 °C
View Scheme
1-Phenyl-1-propanol
93-54-9

1-Phenyl-1-propanol

(E)-tamoxifen
13002-65-8

(E)-tamoxifen

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 95 percent / PBr3 / CH2Cl2 / 20 °C
2.1: 120 h / 130 °C
2.2: 45 percent / NaOH / H2O / 20 °C
3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C
3.2: 12 percent / tetrahydrofuran; hexane / 48 h / -78 °C
View Scheme
1-bromopropylbenzene
2114-36-5, 101308-38-7

1-bromopropylbenzene

(E)-tamoxifen
13002-65-8

(E)-tamoxifen

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 120 h / 130 °C
1.2: 45 percent / NaOH / H2O / 20 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C
2.2: 12 percent / tetrahydrofuran; hexane / 48 h / -78 °C
View Scheme
4-Hydroxybenzophenone
1137-42-4

4-Hydroxybenzophenone

(E)-tamoxifen
13002-65-8

(E)-tamoxifen

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 90 percent / sodium ethoxide / ethanol / 24 h / Heating
2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C
2.2: 12 percent / tetrahydrofuran; hexane / 48 h / -78 °C
View Scheme
iodobenzene
591-50-4

iodobenzene

4-CF3C6H4COCr(CO)5(1-)NMe4(1+)

4-CF3C6H4COCr(CO)5(1-)NMe4(1+)

(E)-tamoxifen
13002-65-8

(E)-tamoxifen

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 52 percent / diethyl ether; tetrahydrofuran / 16 h / 20 °C
2.1: BCl3 / CH2Cl2 / 5 h / -41 °C
2.2: 82 percent / Et3N / CH2Cl2 / 14 h / 20 °C
3.1: 95 percent / aq. NaOH / Pd[P(t-Bu)3]2 / tetrahydrofuran / 24 h / 60 °C
View Scheme
C17H20MgNSi

C17H20MgNSi

(E)-tamoxifen
13002-65-8

(E)-tamoxifen

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 52 percent / diethyl ether; tetrahydrofuran / 16 h / 20 °C
2.1: BCl3 / CH2Cl2 / 5 h / -41 °C
2.2: 82 percent / Et3N / CH2Cl2 / 14 h / 20 °C
3.1: 95 percent / aq. NaOH / Pd[P(t-Bu)3]2 / tetrahydrofuran / 24 h / 60 °C
View Scheme
E-(Et)(C6H5)CC(C6H5)(SiMe2C5H4N)
624731-31-3

E-(Et)(C6H5)CC(C6H5)(SiMe2C5H4N)

(E)-tamoxifen
13002-65-8

(E)-tamoxifen

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: BCl3 / CH2Cl2 / 5 h / -41 °C
1.2: 82 percent / Et3N / CH2Cl2 / 14 h / 20 °C
2.1: 95 percent / aq. NaOH / Pd[P(t-Bu)3]2 / tetrahydrofuran / 24 h / 60 °C
View Scheme
(E)-tamoxifen
13002-65-8

(E)-tamoxifen

rel-(1R,2S)-1-<4-<2-(dimethylamino)ethoxy>phenyl>-1,2-diphenylbutane
109640-21-3

rel-(1R,2S)-1-<4-<2-(dimethylamino)ethoxy>phenyl>-1,2-diphenylbutane

Conditions
ConditionsYield
With ammonium formate; palladium on activated charcoal In ethanol at 80℃; for 4.5h;83%
(E)-tamoxifen
13002-65-8

(E)-tamoxifen

tamoxifen
10540-29-1

tamoxifen

Conditions
ConditionsYield
With trifluorormethanesulfonic acid In dichloromethane at 0℃; for 3h;51%
With trifluorormethanesulfonic acid In dichloromethane at 0℃; for 3h;51%
With pyridine; bromine In diethyl ether; dichloromethane for 2h; Ambient temperature; Irradiation; Yield given;

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