Paliperidone/Iloperidone Intermediate 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one[CAS:130049-82-0] HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research an
Cas:130049-82-0
Min.Order:500 Gram
Negotiable
Type:Other
inquiryDayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:130049-82-0
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:130049-82-0
Min.Order:0 Metric Ton
Negotiable
Type:Manufacturers
inquiryProduct Description Product Name 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido [1,2-a]pyrimidin-4-one CAS No. 130049-82-0 Appearance White powder Assay ≥99%
Cas:130049-82-0
Min.Order:1 Gram
FOB Price: $345.0
Type:Lab/Research institutions
inquiryhigh quality Appearance:White or off white powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
Cas:130049-82-0
Min.Order:1 Kilogram
Negotiable
Type:Manufacturers
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:130049-82-0
Min.Order:1
Negotiable
Type:Other
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:130049-82-0
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryCompetitive Price High Quality Fast Delivery custom-made Welcome to Henan Tianfu Chemical Co., Ltd. website. Our company engages in Sodium Tripolyphosphate (STPP) and Sodium Hexametabphosphate (SHMP) production; development of noble me
Cas:130049-82-0
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
Cas:130049-82-0
Min.Order:1 Kilogram
FOB Price: $1.0 / 10.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:130049-82-0
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:130049-82-0
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:130049-82-0
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryProduct Name: 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one CAS: 130049-82-0 MF: C11H15ClN2O2 MW: 242.7 EINECS: 603-382-2 Mol File: 130049-82-0.mol 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-h
Cas:130049-82-0
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:130049-82-0
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:130049-82-0
Min.Order:1 Kilogram
FOB Price: $157.0 / 163.0
Type:Trading Company
inquiry3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one CAS:130049-82-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade
Cas:130049-82-0
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:130049-82-0
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several
Cas:130049-82-0
Min.Order:25 Gram
FOB Price: $90.0 / 100.0
Type:Trading Company
inquiryProduct Name: 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one Synonyms: Paliperidone-8;3-(2-CHLOROEETHYL)-6,7,8,9-TETRAHYDRO-9-HYDROXY-2-METHYL-4H-PYRIDO (1,2-A) PYRIMIDIN-4-ONE;Paliperidone Chloro IMpurity
Cas:130049-82-0
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Cas:130049-82-0
Min.Order:0
Negotiable
Type:Manufacturers
inquiryTriumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and qua
Cas:130049-82-0
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Cas:130049-82-0
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:130049-82-0
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryadvantage: 1. The best price, satisfactory quality; 2. customers have the right to choose the delivery of parcels (EMS, DHL, FedEx, UPS); 3. customers have the right to choose from the recent effective packaging methods of their products packaging
Cas:130049-82-0
Min.Order:1 Gram
Negotiable
Type:Other
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:130049-82-0
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryWhy Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu
Cas:130049-82-0
Min.Order:1 Gram
Negotiable
Type:Other
inquiryChemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff
Cas:130049-82-0
Min.Order:100 Gram
Negotiable
Type:Other
inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:130049-82-0
Min.Order:1 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:130049-82-0
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiry3-(2-chloroethyl)-2-methyl-9-hydroxy-4H-pyrido[1,2-a]pyrimidin-4-one
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
Conditions | Yield |
---|---|
Stage #1: 3-(2-chloroethyl)-2-methyl-9-hydroxy-4H-pyrido[1,2-a]pyrimidin-4-one With hydrogenchloride; palladium 10% on activated carbon In ethanol; water Green chemistry; Stage #2: With hydrogen In ethanol; water at 80℃; under 11251.1 Torr; Catalytic behavior; Solvent; Reagent/catalyst; Temperature; Pressure; Green chemistry; | 99.32% |
Stage #1: 3-(2-chloroethyl)-2-methyl-9-hydroxy-4H-pyrido[1,2-a]pyrimidin-4-one With hydrogen; palladium 10% on activated carbon In acetic acid at 25 - 30℃; under 2206.72 Torr; Stage #2: With sodium hydroxide In dichloromethane; water pH=5.5 - 6.0; Product distribution / selectivity; | |
With hydrogen; palladium 10% on activated carbon In acetic acid at 35℃; under 735.572 - 2206.72 Torr; Product distribution / selectivity; |
3-(2-chloroethyl)-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one monohydrochloride
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
Conditions | Yield |
---|---|
Stage #1: 3-(2-chloroethyl)-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one monohydrochloride With hydrogen; 5%-palladium/activated carbon In water; isopropyl alcohol at 55℃; under 760.051 Torr; Inert atmosphere; Stage #2: With potassium acetate In water Product distribution / selectivity; | 92% |
Stage #1: 3-(2-chloroethyl)-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one monohydrochloride In methanol at 50 - 55℃; Stage #2: With hydrogen; palladium 10% on activated carbon In methanol at 50 - 55℃; for 8h; | 68.25% |
Stage #1: 3-(2-chloroethyl)-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one monohydrochloride With pyrographite In methanol at 50 - 55℃; for 0.75h; Large scale; Stage #2: With palladium 10% on activated carbon; hydrogen In methanol; dichloromethane at 25 - 30℃; under 2172.08 - 2947.82 Torr; Large scale; | 39% |
C11H14ClN3O2
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
Conditions | Yield |
---|---|
Stage #1: C11H14ClN3O2 With hydrogenchloride; titanium(III) chloride; water at 70℃; for 0.5h; Inert atmosphere; Stage #2: With sodium hydrogencarbonate In water | 87% |
9-(benzyloxy)-3-(2-chloroethyl)-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
Conditions | Yield |
---|---|
With hydrogenchloride; palladium 10% on activated carbon; hydrogen In methanol; water; tert-butyl alcohol at 25 - 30℃; under 775.743 Torr; for 16h; Reagent/catalyst; Solvent; Pressure; | 74.4% |
With hydrogenchloride; hydrogen; palladium 10% on activated carbon In water at 25 - 30℃; | 69% |
With cyclohexene; palladium 10% on activated carbon for 19h; Product distribution / selectivity; Heating / reflux; |
9-benzyloxy-3-(2-chloro-ethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
Conditions | Yield |
---|---|
Stage #1: 9-benzyloxy-3-(2-chloro-ethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one With hydrogenchloride; hydrogen; 5% palladium over charcoal In methanol at 27℃; for 36h; pH=3.0; Inert atmosphere; Stage #2: With sodium hydroxide In water at 5℃; pH=10 - 11; | 72.6% |
With hydrogenchloride; hydrogen; palladium 10% on activated carbon In water at 25 - 30℃; under 735.572 - 1471.14 Torr; for 4 - 6h; | 69% |
3-(2-chloroethyl)-6,7,8,9-tetrahydro-9-acetyloxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
Conditions | Yield |
---|---|
With sodium hydroxide In water |
3-(2-chloroethyl)-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one monohydrochloride
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
Conditions | Yield |
---|---|
Stage #1: 3-(2-chloroethyl)-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one monohydrochloride With hydrogen; 1% Pd/C In acetic acid at 35℃; under 2206.72 - 2574.5 Torr; for 6h; Stage #2: With sodium hydroxide In water at 0℃; for 1h; pH=6; Product distribution / selectivity; |
9-(benzyloxy)-3-(2-chloroethyl)-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
A
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
B
3-(2-chloroethyl)-2-methyl-9-hydroxy-4H-pyrido[1,2-a]pyrimidin-4-one
Conditions | Yield |
---|---|
With hydrogenchloride; hydrogen; 1% Pd/C In methanol; water at 25 - 30℃; under 735.572 - 1471.14 Torr; for 1h; Product distribution / selectivity; Autoclave; | A 28.8 %Chromat. B 62 %Chromat. |
9-(benzyloxy)-3-(2-chloroethyl)-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
A
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
B
3-ethyl-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
Conditions | Yield |
---|---|
With hydrogenchloride; hydrogen; 1% Pd/C In methanol; water at 25 - 30℃; under 735.572 - 1471.14 Torr; for 3.5h; Product distribution / selectivity; Autoclave; | A 48.9 %Chromat. B 39 %Chromat. |
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one oxalate
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
Conditions | Yield |
---|---|
With potassium acetate In water at 0 - 5℃; for 1h; pH=4.8; |
3-acetyl-2-oxo-4,5-dihydrofuran
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: toluene-4-sulfonic acid / xylene / 20.5 h / 25 - 142 °C 2: hydrogenchloride / isopropyl alcohol; methanol / 1 h / 60 - 65 °C / pH 1 - 3 3: hydrogen; zinc(II) chloride / palladium on carbon / methanol / 35 - 55 °C View Scheme | |
Multi-step reaction with 3 steps 1: toluene-4-sulfonic acid / xylene / Reflux 2: thionyl chloride / N,N-dimethyl-formamide / 65 - 70 °C 3: hydrogen / palladium 10% on activated carbon / methanol / 23 - 30 °C / 1471.14 - 2206.72 Torr View Scheme | |
Multi-step reaction with 2 steps 1.1: trichlorophosphate / toluene 1.2: 7 h / 90 - 95 °C 1.3: 1 h / 90 - 95 °C 2.1: hydrogen / palladium 10% on activated carbon / acetic acid / 35 °C / 735.57 - 2206.72 Torr View Scheme | |
Multi-step reaction with 3 steps 1.1: toluene / 0.25 h 1.2: 20 h / 70 °C / Reflux 2.1: hydrogenchloride / toluene; water / 9 h / 65 - 70 °C 3.1: hydrogen; palladium on activated charcoal; acetic acid / 6 h / 35 °C / 2250.23 - 2625.26 Torr / Autoclave View Scheme | |
Multi-step reaction with 2 steps 1.1: trichlorophosphate / toluene / 24 h / 30 - 40 °C / Large scale 1.2: 0 - 5 °C / Large scale 2.1: pyrographite / methanol / 0.75 h / 50 - 55 °C / Large scale 2.2: 25 - 30 °C / 2172.08 - 2947.82 Torr / Large scale View Scheme |
9-hydroxy-3-hydroxyethyl-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogenchloride / isopropyl alcohol; methanol / 1 h / 60 - 65 °C / pH 1 - 3 2: hydrogen; zinc(II) chloride / palladium on carbon / methanol / 35 - 55 °C View Scheme | |
Multi-step reaction with 2 steps 1: thionyl chloride / N,N-dimethyl-formamide / 65 - 70 °C 2: hydrogen / palladium 10% on activated carbon / methanol / 23 - 30 °C / 1471.14 - 2206.72 Torr View Scheme |
2-amino-3-hydroxypyridine
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: toluene-4-sulfonic acid / xylene / 20.5 h / 25 - 142 °C 2: hydrogenchloride / isopropyl alcohol; methanol / 1 h / 60 - 65 °C / pH 1 - 3 3: hydrogen; zinc(II) chloride / palladium on carbon / methanol / 35 - 55 °C View Scheme | |
Multi-step reaction with 3 steps 1: toluene-4-sulfonic acid / xylene / Reflux 2: thionyl chloride / N,N-dimethyl-formamide / 65 - 70 °C 3: hydrogen / palladium 10% on activated carbon / methanol / 23 - 30 °C / 1471.14 - 2206.72 Torr View Scheme | |
Multi-step reaction with 2 steps 1.1: trichlorophosphate / toluene / 24 h / 30 - 40 °C / Large scale 1.2: 0 - 5 °C / Large scale 2.1: pyrographite / methanol / 0.75 h / 50 - 55 °C / Large scale 2.2: 25 - 30 °C / 2172.08 - 2947.82 Torr / Large scale View Scheme | |
Multi-step reaction with 4 steps 1: sodium hydroxide; tetrabutylammomium bromide / water / 6 h / 40 - 75 °C / Large scale 2: toluene-4-sulfonic acid / toluene / Reflux; Large scale 3: trichlorophosphate / 1,2-dimethoxyethane / 6 h / Reflux; Large scale 4: hydrogenchloride; palladium 10% on activated carbon; hydrogen / water; methanol; tert-butyl alcohol / 16 h / 25 - 30 °C / 775.74 Torr View Scheme |
3-acetyl-2-oxo-4,5-dihydrofuran
2-amino-3-benzyloxypyridine
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
Conditions | Yield |
---|---|
With hydrogenchloride; hydrogen; trichlorophosphate In cyclohexane; acetic acid; toluene |
2-amino-3-benzyloxypyridine
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: trichlorophosphate / toluene 1.2: 7 h / 90 - 95 °C 1.3: 1 h / 90 - 95 °C 2.1: hydrogen / palladium 10% on activated carbon / acetic acid / 35 °C / 735.57 - 2206.72 Torr View Scheme | |
Multi-step reaction with 3 steps 1.1: toluene / 0.25 h 1.2: 20 h / 70 °C / Reflux 2.1: hydrogenchloride / toluene; water / 9 h / 65 - 70 °C 3.1: hydrogen; palladium on activated charcoal; acetic acid / 6 h / 35 °C / 2250.23 - 2625.26 Torr / Autoclave View Scheme | |
Multi-step reaction with 3 steps 1: toluene-4-sulfonic acid / toluene / Reflux; Large scale 2: trichlorophosphate / 1,2-dimethoxyethane / 6 h / Reflux; Large scale 3: hydrogenchloride; palladium 10% on activated carbon; hydrogen / water; methanol; tert-butyl alcohol / 16 h / 25 - 30 °C / 775.74 Torr View Scheme |
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
Conditions | Yield |
---|---|
With palladium on activated charcoal; hydrogen; acetic acid at 35℃; under 2250.23 - 2625.26 Torr; for 6h; Time; Temperature; Autoclave; | 22 g |
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
(Z)-(2,4-difluorophenyl) (4-piperidinyl)methanone, oxime monohydrochloride
Conditions | Yield |
---|---|
With potassium iodide; sodium hydroxide In acetonitrile for 10h; Reflux; | 99.2% |
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
chloromethyl methyl ether
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane at 45℃; Reagent/catalyst; | 98% |
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
1-hexadecylcarboxylic acid
3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-9-hydroxy-4H-pyrido[1,2-a]pyrimidine-4-one palmitate ester
Conditions | Yield |
---|---|
Stage #1: 3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one; 1-hexadecylcarboxylic acid With dmap; triethylamine In dichloromethane at 25 - 30℃; for 0.25h; Stage #2: With pivaloyl chloride In dichloromethane at 25 - 40℃; for 2h; | 95% |
Stage #1: 3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one; 1-hexadecylcarboxylic acid With dmap; triethylamine In dichloromethane at 25 - 30℃; for 0.25h; Stage #2: With pivaloyl chloride In dichloromethane at 25 - 40℃; for 2h; | 95% |
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
paliperidone
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In methanol for 24h; Reflux; | 94% |
With N-ethyl-N,N-diisopropylamine In methanol Product distribution / selectivity; Reflux; | 93% |
With N-ethyl-N,N-diisopropylamine In methanol at 60℃; Reagent/catalyst; Inert atmosphere; | 90% |
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
methanesulfonyl chloride
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 0.5h; Cooling with ice; | 93% |
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
paliperidone
Conditions | Yield |
---|---|
With diisopropylamine In methanol for 12h; Time; Inert atmosphere; Reflux; | 88% |
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
Conditions | Yield |
---|---|
With 18-crown-6 ether; potassium carbonate In tetrahydrofuran Reflux; | 82% |
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
Conditions | Yield |
---|---|
With diethylamino-sulfur trifluoride In dichloromethane at 20℃; for 3h; Cooling with ice; | 74% |
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
duloxetine hydrochloride
Conditions | Yield |
---|---|
With potassium carbonate; sodium iodide In N,N-dimethyl-formamide at 65℃; Inert atmosphere; | 72% |
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
(2,4-difluorophenyl)-piperidin-4-yl-methanone oxime hydrochloride
3-(2-{4-((2,4-difluorophenyl)hydroxyiminomethyl)piperidin-1-yl}ethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one
Conditions | Yield |
---|---|
With potassium carbonate; potassium iodide In acetonitrile for 16h; Reflux; | 70% |
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
6-fluoro-3-(4-piperidinyl)benzo[d]isoxazole
paliperidone
Conditions | Yield |
---|---|
With sodium hydrogencarbonate; potassium iodide In water; acetonitrile at 65℃; for 16h; Reagent/catalyst; Solvent; Temperature; | 60% |
With N-ethyl-N,N-diisopropylamine In methanol at 50 - 70℃; | 55% |
With sodium carbonate In ethanol at 58 - 62℃; for 24h; Product distribution / selectivity; |
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
Conditions | Yield |
---|---|
With potassium carbonate; potassium iodide In acetonitrile at 85℃; | 58% |
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
Conditions | Yield |
---|---|
With potassium carbonate; potassium iodide In acetonitrile at 85℃; | 56% |
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
Conditions | Yield |
---|---|
With potassium carbonate; potassium iodide In acetonitrile for 12h; Reflux; | 49% |
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
Conditions | Yield |
---|---|
Stage #1: C27H31F2N5O4 In ethanol at 20 - 30℃; Acidic conditions; Stage #2: 3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one With N-ethyl-N,N-diisopropylamine In methanol Reflux; | 49% |
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
Conditions | Yield |
---|---|
With potassium carbonate; potassium iodide In acetonitrile at 80℃; | 46.6% |
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
(±)-3-(2-chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one monohydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In water; butanone pH=2; | 46% |
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
Conditions | Yield |
---|---|
Stage #1: C28H32F2N4O4 In ethanol at 20 - 30℃; Acidic conditions; Stage #2: 3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one With N-ethyl-N,N-diisopropylamine In methanol Reflux; | 42% |
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
Conditions | Yield |
---|---|
With potassium carbonate; potassium iodide In acetonitrile Reflux; | 41% |
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
Conditions | Yield |
---|---|
Stage #1: C28H32F2N4O4 In ethanol at 20 - 30℃; Acidic conditions; Stage #2: 3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one With N-ethyl-N,N-diisopropylamine In methanol Reflux; | 41% |
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In methanol Reflux; | 36% |
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In methanol Reflux; | 36% |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View