Products

Refine

Country

Business Type

Certificate

Display

Hangzhou Think Chemical Co. Ltd

Product: Risperidone Intermediate Chemical name: 6-Fluoro-3-(4-Piperidinyl)-1,2-Benzisoxazole HCL[CAS:84163-13-3] Batch No: 090806 Manufacturing Date: Aug., 2009 Expiry Date: Aug., 2011 Analysis report number:

Manufacture 6-Fluoro-3-(4-Piperidinyl)-1,2-Benzisoxazole HCl with documentsl

Cas:84163-13-3

Min.Order:500 Gram

Negotiable

Type:Other

inquiry

Joyochem Co., Ltd.

Iloperidone intermediate factory, Industrialization stage Appearance:white powder Storage:make to order Package:25KG/drum Application:Iloperidone intermediate Transportation:by air or sea Port:QINGDAO

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride USD200/kg Iloperidone intermediate

Cas:84163-13-3

Min.Order:1 Kilogram

FOB Price: $200.0 / 245.0

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride Manufacturer/High quality/Best price/In stock

Cas:84163-13-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Jinan Finer Chemical Co., Ltd

Product Description Product Name 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride CAS No. 84163-13-3 Appearance White powder Assay ≥99% Capacity 50mt/year

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

Cas:84163-13-3

Min.Order:1 Gram

FOB Price: $52.0

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Large Stock 99.0% 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole HCl 84163-13-3 Producer

Cas:84163-13-3

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

Cas:84163-13-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

Cas:84163-13-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

CHENGDU YANXI is a comprehensive manufacturer and an international distribution of products throughout the world. Specialized in Scrap metal, Chemical raw materials, Paper products and color industry. We aim to become leading position in global dis

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazol HCl;Risperidone intermediate CAS No.: 84163-13-3

Cas:84163-13-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Trading Company

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

Cas:84163-13-3

Min.Order:1 Kilogram

FOB Price: $2.0 / 10.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Henan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license. We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the com

TIANFU-CHEM - 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

Cas:84163-13-3

Min.Order:1 Kilogram

FOB Price: $1000.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 84163-13-3 with competitive price

Cas:84163-13-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride CAS:84163-13-3

Cas:84163-13-3

Min.Order:1 Kilogram

FOB Price: $38.0 / 59.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Product name 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride Synonyms (5-chloro-2,4-difluorophenyl)(piperidin-4-yl)methanone CAS No. 84163-13-3 EINECS No.

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

Cas:84163-13-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1,2-Benzisoxazole,6-fluoro-3-(4-piperidinyl)-, hydrochloride (1:1) 84163-13-3

Cas:84163-13-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

Cas:84163-13-3

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

piperoprolone intermediate, 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride CAS:84163-13-3

Cas:84163-13-3

Min.Order:1 Kilogram

FOB Price: $81.9 / 87.3

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

Cas:84163-13-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1,2-Benzisoxazole,6-fluoro-3-(4-piperidinyl)-, hydrochloride (1:1)

Cas:84163-13-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi

Chemical drugs 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole HCl

Cas:84163-13-3

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:84163-13-3

Cas:84163-13-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride cas:84163-13-3

Cas:84163-13-3

Min.Order:25 Gram

FOB Price: $90.0 / 100.0

Type:Trading Company

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride Synonyms: (5-chloro-2,4-difluorophenyl)(piperidin-4-yl)methanone;6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride Paliperidone intermediate;4-(6-FLUORO-1,2-BENZISO

Product Name: 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride supplier best quality

Cas:84163-13-3

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

6-Fluoro-3-(4-piperidinyl)-1,2- benzisoxazole Hydrochloride

Cas:84163-13-3

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

Cas:84163-13-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

1,2-Benzisoxazole,6-fluoro-3-(4-piperidinyl)-, hydrochloride (1:1)

Cas:84163-13-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 6-Fluoro-3-(4-Piperidinyl)-1,2-Benzisoxazole Hydrochloride

Cas:84163-13-3

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

Cas:84163-13-3

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: 6-Fluoro-3-(4-Piperidinyl)-1,2-Benzisoxazole Hydrochloride CAS No.:84163-13-3 Molecule Formula:C12H14ClFN2O Molecule Weight:256.70 Purity: 98.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standar

Best Quality 6-Fluoro-3-(4-Piperidinyl)-1,2-Benzisoxazole Hydrochloride with good supplier

Cas:84163-13-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

(2,4-difluorophenyl)(4-piperidinyl)methanone oxime
84163-46-2

(2,4-difluorophenyl)(4-piperidinyl)methanone oxime

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

Conditions
ConditionsYield
With N-methylcyclohexylamine; potassium tert-butylate In water; toluene for 6h; Reflux;97.8%
Stage #1: (2,4-difluorophenyl)(4-piperidinyl)methanone oxime With potassium hydroxide In water; toluene for 6h; Reflux; Inert atmosphere;
Stage #2: With hydrogenchloride In ethanol; water at 70 - 80℃; Temperature;
96.33%
(2,4-Difluoro-phenyl)-piperidin-4-yl-methanone hydrochloride

(2,4-Difluoro-phenyl)-piperidin-4-yl-methanone hydrochloride

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

Conditions
ConditionsYield
Stage #1: (2,4-Difluoro-phenyl)-piperidin-4-yl-methanone hydrochloride With hydroxylamine hydrochloride; potassium hydroxide In methanol
Stage #2: With potassium hydroxide In methanol at 40 - 45℃; for 12h;
Stage #3: With hydrogenchloride In methanol; water at 0 - 30℃; for 2h; pH=< 1; Solvent; Reagent/catalyst; Temperature; Concentration;
90.4%
Multi-step reaction with 2 steps
1: hydroxylamine hydrochloride; N-methylcyclohexylamine / ethanol / 12 h / 60 °C
2: potassium tert-butylate; N-methylcyclohexylamine / water; toluene / 6 h / Reflux
View Scheme
6-fluoro-3-(1-formyl-4-piperidinyl)-1,2-benzisoxazole
84163-41-7

6-fluoro-3-(1-formyl-4-piperidinyl)-1,2-benzisoxazole

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethanol for 3h; Heating; Yield given;
With hydrogenchloride In methanol; ethanol; benzene1.25 g (31.8%)
With hydrogenchloride
1-formyl-4-(2,4-difluorobenzoyl)piperidine oxime
84162-94-7

1-formyl-4-(2,4-difluorobenzoyl)piperidine oxime

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaH / dimethylformamide / 4 h / 70 - 75 °C
2: aq. HCl / ethanol / 3 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: potassium hydroxide / isopropyl alcohol; water
2: hydrogenchloride
View Scheme
6-fluoro-3-(1-methylpiperidin-4-yl)benzisoxazole
416852-17-0

6-fluoro-3-(1-methylpiperidin-4-yl)benzisoxazole

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

Conditions
ConditionsYield
With 2-Chloroethyl chloroformate; triethylamine In 1,2-dichloro-ethane at 0 - 20℃;
1-formylisonipecotoyl chloride
84163-43-9

1-formylisonipecotoyl chloride

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: aluminum (III) chloride
2: hydrogenchloride; hydroxylamine hydrochloride / isopropyl alcohol; water
3: potassium hydroxide / isopropyl alcohol; water
4: hydrogenchloride
View Scheme
isonipecotic acid
498-94-2

isonipecotic acid

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: acetic anhydride
2: thionyl chloride
3: aluminum (III) chloride
4: hydrogenchloride; hydroxylamine hydrochloride / isopropyl alcohol; water
5: potassium hydroxide / isopropyl alcohol; water
6: hydrogenchloride
View Scheme
1-Formylisonipecotic acid
84163-42-8, 67659-34-1, 67659-33-0

1-Formylisonipecotic acid

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: thionyl chloride
2: aluminum (III) chloride
3: hydrogenchloride; hydroxylamine hydrochloride / isopropyl alcohol; water
4: potassium hydroxide / isopropyl alcohol; water
5: hydrogenchloride
View Scheme
4-(2,4-difluorobenzoyl)-1-piperidinecarboxaldehyde
84162-80-1

4-(2,4-difluorobenzoyl)-1-piperidinecarboxaldehyde

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride; hydroxylamine hydrochloride / isopropyl alcohol; water
2: potassium hydroxide / isopropyl alcohol; water
3: hydrogenchloride
View Scheme
(2,4-difluorophenyl)-piperidin-4-yl-methanone oxime hydrochloride
135634-18-3

(2,4-difluorophenyl)-piperidin-4-yl-methanone oxime hydrochloride

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

Conditions
ConditionsYield
Stage #1: (2,4-difluorophenyl)-piperidin-4-yl-methanone oxime hydrochloride With potassium hydroxide In methanol for 2.5h; Heating;
Stage #2: With hydrogenchloride In water; acetone at 20℃; for 0h; pH=2 - 3;
35 g
C13H15F2NO
416852-15-8

C13H15F2NO

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydroxylamine hydrochloride / pyridine / 60 °C
2: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 70 - 75 °C
3: 2-Chloroethyl chloroformate; triethylamine / 1,2-dichloro-ethane / 0 - 20 °C
View Scheme
C13H16F2N2O
416852-16-9

C13H16F2N2O

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 70 - 75 °C
2: 2-Chloroethyl chloroformate; triethylamine / 1,2-dichloro-ethane / 0 - 20 °C
View Scheme
2,4-difluorobenzaldehyde
1550-35-2

2,4-difluorobenzaldehyde

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: tetrahydrofuran / 20 °C
2: hydroxylamine hydrochloride / pyridine / 60 °C
3: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 70 - 75 °C
4: 2-Chloroethyl chloroformate; triethylamine / 1,2-dichloro-ethane / 0 - 20 °C
View Scheme
(1-methyl-4-piperidyl)magnesium chloride
63463-36-5

(1-methyl-4-piperidyl)magnesium chloride

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: tetrahydrofuran / 20 °C
2: hydroxylamine hydrochloride / pyridine / 60 °C
3: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 70 - 75 °C
4: 2-Chloroethyl chloroformate; triethylamine / 1,2-dichloro-ethane / 0 - 20 °C
View Scheme
1,3-Difluorobenzene
372-18-9

1,3-Difluorobenzene

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: aluminum (III) chloride / dichloromethane / 3 h / 20 °C
2.1: hydrogenchloride / water / 5 h / Reflux
3.1: hydroxylamine hydrochloride / ethanol / 3 h / Reflux
4.1: potassium hydroxide / water; toluene / 6 h / Reflux; Inert atmosphere
4.2: 70 - 80 °C
View Scheme
1-acetylpiperidine-4-carbonyl chloride
59084-16-1

1-acetylpiperidine-4-carbonyl chloride

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: aluminum (III) chloride / dichloromethane / 3 h / 20 °C
2.1: hydrogenchloride / water / 5 h / Reflux
3.1: hydroxylamine hydrochloride / ethanol / 3 h / Reflux
4.1: potassium hydroxide / water; toluene / 6 h / Reflux; Inert atmosphere
4.2: 70 - 80 °C
View Scheme
1-[4-(2.4-Difluoro-benzoyl)-piperidin-1-yl]-ethanone
84162-82-3

1-[4-(2.4-Difluoro-benzoyl)-piperidin-1-yl]-ethanone

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydrogenchloride / water / 5 h / Reflux
2.1: hydroxylamine hydrochloride / ethanol / 3 h / Reflux
3.1: potassium hydroxide / water; toluene / 6 h / Reflux; Inert atmosphere
3.2: 70 - 80 °C
View Scheme
Boc-Trp-OH
13139-14-5

Boc-Trp-OH

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

C28H31FN4O4
1270202-32-8

C28H31FN4O4

Conditions
ConditionsYield
Stage #1: Boc-Trp-OH With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0℃; for 0.166667h;
Stage #2: 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride With 4-methyl-morpholine In N,N-dimethyl-formamide at 0 - 20℃; pH=8;
96%
4-(3-chloropropoxy)-3-methoxyacetophenone
58113-30-7

4-(3-chloropropoxy)-3-methoxyacetophenone

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

iloperidone
133454-47-4

iloperidone

Conditions
ConditionsYield
Stage #1: 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride With sodium hydroxide In water at 25 - 30℃; for 0.25h; Industrial scale; Green chemistry;
Stage #2: 4-(3-chloropropoxy)-3-methoxyacetophenone In water at 25 - 30℃; for 0.25h; Industrial scale; Green chemistry;
Stage #3: With tetrabutylammomium bromide In n-heptane; water at 65 - 70℃; Reagent/catalyst; Solvent; Temperature; Concentration; Time; Industrial scale; Green chemistry;
95%
With sodium hydrogencarbonate In toluene; acetonitrile at 76℃; for 6h; Temperature;90.5%
With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 16h;
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
130049-82-0

3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

paliperidone
144598-75-4

paliperidone

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In methanol for 24h; Reflux;94%
With N-ethyl-N,N-diisopropylamine In methanol Product distribution / selectivity; Reflux;93%
With N-ethyl-N,N-diisopropylamine In methanol at 60℃; Reagent/catalyst; Inert atmosphere;90%
3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one monohydrochloride

3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one monohydrochloride

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

Risperidone
106266-06-2

Risperidone

Conditions
ConditionsYield
With sodium carbonate In methanol at 73 - 75℃; for 4 - 4.5h; Product distribution / selectivity;93.6%
With sodium carbonate In water at 25 - 55℃; for 9h; Product distribution / selectivity;
With sodium carbonate In water; acetonitrile at 25 - 75℃; for 8h; Product distribution / selectivity;
3-(2-chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
63234-80-0

3-(2-chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

Risperidone
106266-06-2

Risperidone

Conditions
ConditionsYield
With sodium carbonate In water at 110 - 120℃; for 0.666667h; Product distribution / selectivity;93.2%
With sodium carbonate; potassium iodide In N,N-dimethyl-formamide at 80℃; for 10h; Temperature;76.9%
N-tert-butoxycarbonyl-L-phenylalanine
13734-34-4

N-tert-butoxycarbonyl-L-phenylalanine

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

C26H30FN3O4
1270202-31-7

C26H30FN3O4

Conditions
ConditionsYield
Stage #1: N-tert-butoxycarbonyl-L-phenylalanine With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0℃; for 0.166667h;
Stage #2: 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride With 4-methyl-morpholine In N,N-dimethyl-formamide at 0 - 20℃; pH=8;
92%
Stage #1: N-tert-butoxycarbonyl-L-phenylalanine With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In N,N-dimethyl-formamide at 0℃; for 0.166667h;
Stage #2: 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; pH=8;
85%
3-(2-chloroethyl)-9-(methoxymethoxy)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-α]pyrimidin-4-one

3-(2-chloroethyl)-9-(methoxymethoxy)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-α]pyrimidin-4-one

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

3-(2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl)-9-(methoxymethoxy)-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-α]pyrimidin-4-one

3-(2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl)-9-(methoxymethoxy)-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-α]pyrimidin-4-one

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetonitrile at 75 - 78℃; Reagent/catalyst;92%
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

2-chloropropionyl chloride
625-36-5

2-chloropropionyl chloride

3-chloro-1-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)propan-1-one

3-chloro-1-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)propan-1-one

Conditions
ConditionsYield
With sodium hydroxide In dichloromethane; water at 0 - 20℃; for 5h; Large scale;91%
N-tert-butoxycarbonyl-O-2,6-dichlorobenzyl-L-tyrosine
40298-71-3

N-tert-butoxycarbonyl-O-2,6-dichlorobenzyl-L-tyrosine

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

C33H34Cl2FN3O5
1270202-33-9

C33H34Cl2FN3O5

Conditions
ConditionsYield
Stage #1: N-tert-butoxycarbonyl-O-2,6-dichlorobenzyl-L-tyrosine With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0℃; for 0.166667h;
Stage #2: 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride With 4-methyl-morpholine In N,N-dimethyl-formamide at 0 - 20℃; pH=8;
90.9%
Stage #1: N-tert-butoxycarbonyl-O-2,6-dichlorobenzyl-L-tyrosine With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In N,N-dimethyl-formamide at 0℃; for 0.166667h;
Stage #2: 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; pH=8;
84%
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

Boc-Gly-Gly-Ala-Pro-OH
151396-21-3

Boc-Gly-Gly-Ala-Pro-OH

C29H39FN6O7
1270202-34-0

C29H39FN6O7

Conditions
ConditionsYield
Stage #1: Boc-Gly-Gly-Ala-Pro-OH With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0℃; for 0.166667h;
Stage #2: 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride With 4-methyl-morpholine In N,N-dimethyl-formamide at 0 - 20℃; pH=8;
90.5%
8-(3-chloropropanoyl)-5,6-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-4(2H)-one
157649-20-2

8-(3-chloropropanoyl)-5,6-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-4(2H)-one

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

8-(3-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)propanoyl)-5,6-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-4(2H)-one

8-(3-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)propanoyl)-5,6-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-4(2H)-one

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetonitrile Reflux;89.9%
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

Boc-Gly-Val-Gly-Val-Pro

Boc-Gly-Val-Gly-Val-Pro

C36H52FN7O8
1270202-37-3

C36H52FN7O8

Conditions
ConditionsYield
Stage #1: Boc-Gly-Val-Gly-Val-Pro With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0℃; for 0.166667h;
Stage #2: 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride With 4-methyl-morpholine In N,N-dimethyl-formamide at 0 - 20℃; pH=8;
89.1%
Boc-Glu(OBzl)-OH
13574-13-5

Boc-Glu(OBzl)-OH

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

C29H34FN3O6
1646250-75-0

C29H34FN3O6

Conditions
ConditionsYield
Stage #1: Boc-Glu(OBzl)-OH With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In N,N-dimethyl-formamide at 0℃; for 0.166667h;
Stage #2: 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; pH=8;
89%
Boc-GFGFP-OH
1270202-28-2

Boc-GFGFP-OH

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

C44H52FN7O8
1270202-38-4

C44H52FN7O8

Conditions
ConditionsYield
Stage #1: Boc-GFGFP-OH With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0℃; for 0.166667h;
Stage #2: 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride With 4-methyl-morpholine In N,N-dimethyl-formamide at 0 - 20℃; pH=8;
88.5%
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

Boc-Gly-Gly-Phe-Pro-OH
76046-35-0

Boc-Gly-Gly-Phe-Pro-OH

C35H43FN6O7
1270202-36-2

C35H43FN6O7

Conditions
ConditionsYield
Stage #1: Boc-Gly-Gly-Phe-Pro-OH With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0℃; for 0.166667h;
Stage #2: 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride With 4-methyl-morpholine In N,N-dimethyl-formamide at 0 - 20℃; pH=8;
88.1%
3-(2-iodoethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
885706-66-1

3-(2-iodoethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

Risperidone
106266-06-2

Risperidone

Conditions
ConditionsYield
With potassium carbonate In acetone for 6h; Heating / reflux;87.4%
Boc-Lys(Z)-OH
2389-45-9

Boc-Lys(Z)-OH

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

C31H39FN4O6
1646250-76-1

C31H39FN4O6

Conditions
ConditionsYield
Stage #1: Boc-Lys(Z)-OH With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In N,N-dimethyl-formamide at 0℃; for 0.166667h;
Stage #2: 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; pH=8;
87%
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

Boc-Gly-Gly-Ile-Pro-OH
397244-47-2

Boc-Gly-Gly-Ile-Pro-OH

C32H45FN6O7
1270202-35-1

C32H45FN6O7

Conditions
ConditionsYield
Stage #1: Boc-Gly-Gly-Ile-Pro-OH With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0℃; for 0.166667h;
Stage #2: 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride With 4-methyl-morpholine In N,N-dimethyl-formamide at 0 - 20℃; pH=8;
86%
BOC-glycine
4530-20-5

BOC-glycine

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

C19H24FN3O4
1426224-71-6

C19H24FN3O4

Conditions
ConditionsYield
Stage #1: BOC-glycine With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0℃; for 0.25h;
Stage #2: 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride With 4-methyl-morpholine In N,N-dimethyl-formamide at 0 - 20℃; pH=8;
85%
Boc-Lys(Boc)-OH
2483-46-7

Boc-Lys(Boc)-OH

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

di‐tert‐butyl {6‐[4‐(6‐fluorobenzo[d]isoxazol‐3‐yl)piperidin‐1‐yl]‐6‐oxohexane‐1,5‐diyl}dicarbamate

di‐tert‐butyl {6‐[4‐(6‐fluorobenzo[d]isoxazol‐3‐yl)piperidin‐1‐yl]‐6‐oxohexane‐1,5‐diyl}dicarbamate

Conditions
ConditionsYield
Stage #1: Boc-Lys(Boc)-OH; 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; pH=8;
Stage #2: With potassium hydrogencarbonate In water for 0.5h; Cooling with ice;
85%
4-(3-chloropropoxy)-3-methoxyacetophenone
58113-30-7

4-(3-chloropropoxy)-3-methoxyacetophenone

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

iloperidone

iloperidone

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In ethyl acetate; N,N-dimethyl-formamide at 80℃; for 50h; Inert atmosphere;84.65%
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

toluene-4-sulfonic acid 2-(4-(3-piperidinopropoxy)phenyl)ethyl ester
409127-88-4

toluene-4-sulfonic acid 2-(4-(3-piperidinopropoxy)phenyl)ethyl ester

6-fluoro-3-(1-(4-(3-(piperidinyl-1-yl)propoxy)phenethyl)piperidinyl-4-yl)benzo[d]isoxazole

6-fluoro-3-(1-(4-(3-(piperidinyl-1-yl)propoxy)phenethyl)piperidinyl-4-yl)benzo[d]isoxazole

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 6h; Reflux;83.2%
tert-butyl 4-(2,4-difluorobenzoyl)piperidine-1-carboxylate
1159825-99-6

tert-butyl 4-(2,4-difluorobenzoyl)piperidine-1-carboxylate

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

C29H33F2N3O4

C29H33F2N3O4

Conditions
ConditionsYield
With potassium carbonate In 1,4-dioxane at 90℃;83%
4-(3-bromopropoxy)benzaldehyde
17954-81-3

4-(3-bromopropoxy)benzaldehyde

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

4-(3-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)propoxy)benzaldehyde

4-(3-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)propoxy)benzaldehyde

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 6h; Reflux;82.4%
1-(tert-butoxycarbonyl)-L-proline
15761-39-4

1-(tert-butoxycarbonyl)-L-proline

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

tert-butyl 2-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-carbonyl)pyrrolidine-1-carboxylate
1426224-72-7

tert-butyl 2-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-carbonyl)pyrrolidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: 1-(tert-butoxycarbonyl)-L-proline With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0℃; for 0.25h;
Stage #2: 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride With 4-methyl-morpholine In N,N-dimethyl-formamide at 0 - 20℃; pH=8;
82%
C11H14ClN3O2
1204248-71-4

C11H14ClN3O2

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

C23H26FN5O3
1204248-69-0

C23H26FN5O3

Conditions
ConditionsYield
With sodium hydrogencarbonate In methanol; N,N-dimethyl-formamide at 70 - 90℃; for 8h; Inert atmosphere;81.8%
rac-5-methanesulfonyl-2-(2,2,2-trifluoro-1-methylethoxy)benzoic acid

rac-5-methanesulfonyl-2-(2,2,2-trifluoro-1-methylethoxy)benzoic acid

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
84163-13-3

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)(5-(methylsulfonyl)-2-((1,1,1-trifluoropropan-2-yl)oxy)phenyl)methanone

(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)(5-(methylsulfonyl)-2-((1,1,1-trifluoropropan-2-yl)oxy)phenyl)methanone

Conditions
ConditionsYield
Stage #1: rac-5-methanesulfonyl-2-(2,2,2-trifluoro-1-methylethoxy)benzoic acid With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 20℃; for 0.5h;
Stage #2: 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride With triethylamine In dichloromethane at 20℃;
81%

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View