Product: Risperidone Intermediate Chemical name: 6-Fluoro-3-(4-Piperidinyl)-1,2-Benzisoxazole HCL[CAS:84163-13-3] Batch No: 090806 Manufacturing Date: Aug., 2009 Expiry Date: Aug., 2011 Analysis report number:
Cas:84163-13-3
Min.Order:500 Gram
Negotiable
Type:Other
inquiryIloperidone intermediate factory, Industrialization stage Appearance:white powder Storage:make to order Package:25KG/drum Application:Iloperidone intermediate Transportation:by air or sea Port:QINGDAO
Cas:84163-13-3
Min.Order:1 Kilogram
FOB Price: $200.0 / 245.0
Type:Manufacturers
inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:84163-13-3
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryProduct Description Product Name 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride CAS No. 84163-13-3 Appearance White powder Assay ≥99% Capacity 50mt/year
Cas:84163-13-3
Min.Order:1 Gram
FOB Price: $52.0
Type:Lab/Research institutions
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:84163-13-3
Min.Order:1
Negotiable
Type:Other
inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:84163-13-3
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryHigh quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce
Cas:84163-13-3
Min.Order:0
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Type:Trading Company
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:84163-13-3
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryCHENGDU YANXI is a comprehensive manufacturer and an international distribution of products throughout the world. Specialized in Scrap metal, Chemical raw materials, Paper products and color industry. We aim to become leading position in global dis
Cas:84163-13-3
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Trading Company
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:84163-13-3
Min.Order:1 Kilogram
FOB Price: $2.0 / 10.0
Type:Trading Company
inquiryHenan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license. We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the com
Cas:84163-13-3
Min.Order:1 Kilogram
FOB Price: $1000.0
Type:Lab/Research institutions
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:84163-13-3
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:84163-13-3
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
Cas:84163-13-3
Min.Order:1 Kilogram
FOB Price: $38.0 / 59.0
Type:Trading Company
inquiryProduct name 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride Synonyms (5-chloro-2,4-difluorophenyl)(piperidin-4-yl)methanone CAS No. 84163-13-3 EINECS No.
Cas:84163-13-3
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:84163-13-3
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryhigh quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
Cas:84163-13-3
Min.Order:1 Kilogram
Negotiable
Type:Manufacturers
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:84163-13-3
Min.Order:1 Kilogram
FOB Price: $81.9 / 87.3
Type:Trading Company
inquiryBeluga chemical professional supply 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2
Cas:84163-13-3
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:84163-13-3
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi
Cas:84163-13-3
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several
Cas:84163-13-3
Min.Order:25 Gram
FOB Price: $90.0 / 100.0
Type:Trading Company
inquiryProduct Name: 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride Synonyms: (5-chloro-2,4-difluorophenyl)(piperidin-4-yl)methanone;6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride Paliperidone intermediate;4-(6-FLUORO-1,2-BENZISO
Cas:84163-13-3
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:84163-13-3
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Cas:84163-13-3
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:84163-13-3
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:84163-13-3
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryEstablished in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
Cas:84163-13-3
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiryProduct name: 6-Fluoro-3-(4-Piperidinyl)-1,2-Benzisoxazole Hydrochloride CAS No.:84163-13-3 Molecule Formula:C12H14ClFN2O Molecule Weight:256.70 Purity: 98.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standar
Cas:84163-13-3
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry(2,4-difluorophenyl)(4-piperidinyl)methanone oxime
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
Conditions | Yield |
---|---|
With N-methylcyclohexylamine; potassium tert-butylate In water; toluene for 6h; Reflux; | 97.8% |
Stage #1: (2,4-difluorophenyl)(4-piperidinyl)methanone oxime With potassium hydroxide In water; toluene for 6h; Reflux; Inert atmosphere; Stage #2: With hydrogenchloride In ethanol; water at 70 - 80℃; Temperature; | 96.33% |
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
Conditions | Yield |
---|---|
Stage #1: (2,4-Difluoro-phenyl)-piperidin-4-yl-methanone hydrochloride With hydroxylamine hydrochloride; potassium hydroxide In methanol Stage #2: With potassium hydroxide In methanol at 40 - 45℃; for 12h; Stage #3: With hydrogenchloride In methanol; water at 0 - 30℃; for 2h; pH=< 1; Solvent; Reagent/catalyst; Temperature; Concentration; | 90.4% |
Multi-step reaction with 2 steps 1: hydroxylamine hydrochloride; N-methylcyclohexylamine / ethanol / 12 h / 60 °C 2: potassium tert-butylate; N-methylcyclohexylamine / water; toluene / 6 h / Reflux View Scheme |
6-fluoro-3-(1-formyl-4-piperidinyl)-1,2-benzisoxazole
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol for 3h; Heating; Yield given; | |
With hydrogenchloride In methanol; ethanol; benzene | 1.25 g (31.8%) |
With hydrogenchloride |
1-formyl-4-(2,4-difluorobenzoyl)piperidine oxime
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: NaH / dimethylformamide / 4 h / 70 - 75 °C 2: aq. HCl / ethanol / 3 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1: potassium hydroxide / isopropyl alcohol; water 2: hydrogenchloride View Scheme |
6-fluoro-3-(1-methylpiperidin-4-yl)benzisoxazole
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
Conditions | Yield |
---|---|
With 2-Chloroethyl chloroformate; triethylamine In 1,2-dichloro-ethane at 0 - 20℃; |
1-formylisonipecotoyl chloride
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: aluminum (III) chloride 2: hydrogenchloride; hydroxylamine hydrochloride / isopropyl alcohol; water 3: potassium hydroxide / isopropyl alcohol; water 4: hydrogenchloride View Scheme |
isonipecotic acid
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: acetic anhydride 2: thionyl chloride 3: aluminum (III) chloride 4: hydrogenchloride; hydroxylamine hydrochloride / isopropyl alcohol; water 5: potassium hydroxide / isopropyl alcohol; water 6: hydrogenchloride View Scheme |
1-Formylisonipecotic acid
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: thionyl chloride 2: aluminum (III) chloride 3: hydrogenchloride; hydroxylamine hydrochloride / isopropyl alcohol; water 4: potassium hydroxide / isopropyl alcohol; water 5: hydrogenchloride View Scheme |
4-(2,4-difluorobenzoyl)-1-piperidinecarboxaldehyde
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydrogenchloride; hydroxylamine hydrochloride / isopropyl alcohol; water 2: potassium hydroxide / isopropyl alcohol; water 3: hydrogenchloride View Scheme |
(2,4-difluorophenyl)-piperidin-4-yl-methanone oxime hydrochloride
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
Conditions | Yield |
---|---|
Stage #1: (2,4-difluorophenyl)-piperidin-4-yl-methanone oxime hydrochloride With potassium hydroxide In methanol for 2.5h; Heating; Stage #2: With hydrogenchloride In water; acetone at 20℃; for 0h; pH=2 - 3; | 35 g |
C13H15F2NO
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydroxylamine hydrochloride / pyridine / 60 °C 2: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 70 - 75 °C 3: 2-Chloroethyl chloroformate; triethylamine / 1,2-dichloro-ethane / 0 - 20 °C View Scheme |
C13H16F2N2O
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 70 - 75 °C 2: 2-Chloroethyl chloroformate; triethylamine / 1,2-dichloro-ethane / 0 - 20 °C View Scheme |
2,4-difluorobenzaldehyde
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: tetrahydrofuran / 20 °C 2: hydroxylamine hydrochloride / pyridine / 60 °C 3: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 70 - 75 °C 4: 2-Chloroethyl chloroformate; triethylamine / 1,2-dichloro-ethane / 0 - 20 °C View Scheme |
(1-methyl-4-piperidyl)magnesium chloride
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: tetrahydrofuran / 20 °C 2: hydroxylamine hydrochloride / pyridine / 60 °C 3: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 70 - 75 °C 4: 2-Chloroethyl chloroformate; triethylamine / 1,2-dichloro-ethane / 0 - 20 °C View Scheme |
1,3-Difluorobenzene
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: aluminum (III) chloride / dichloromethane / 3 h / 20 °C 2.1: hydrogenchloride / water / 5 h / Reflux 3.1: hydroxylamine hydrochloride / ethanol / 3 h / Reflux 4.1: potassium hydroxide / water; toluene / 6 h / Reflux; Inert atmosphere 4.2: 70 - 80 °C View Scheme |
1-acetylpiperidine-4-carbonyl chloride
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: aluminum (III) chloride / dichloromethane / 3 h / 20 °C 2.1: hydrogenchloride / water / 5 h / Reflux 3.1: hydroxylamine hydrochloride / ethanol / 3 h / Reflux 4.1: potassium hydroxide / water; toluene / 6 h / Reflux; Inert atmosphere 4.2: 70 - 80 °C View Scheme |
1-[4-(2.4-Difluoro-benzoyl)-piperidin-1-yl]-ethanone
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: hydrogenchloride / water / 5 h / Reflux 2.1: hydroxylamine hydrochloride / ethanol / 3 h / Reflux 3.1: potassium hydroxide / water; toluene / 6 h / Reflux; Inert atmosphere 3.2: 70 - 80 °C View Scheme |
Boc-Trp-OH
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
C28H31FN4O4
Conditions | Yield |
---|---|
Stage #1: Boc-Trp-OH With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride With 4-methyl-morpholine In N,N-dimethyl-formamide at 0 - 20℃; pH=8; | 96% |
4-(3-chloropropoxy)-3-methoxyacetophenone
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
iloperidone
Conditions | Yield |
---|---|
Stage #1: 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride With sodium hydroxide In water at 25 - 30℃; for 0.25h; Industrial scale; Green chemistry; Stage #2: 4-(3-chloropropoxy)-3-methoxyacetophenone In water at 25 - 30℃; for 0.25h; Industrial scale; Green chemistry; Stage #3: With tetrabutylammomium bromide In n-heptane; water at 65 - 70℃; Reagent/catalyst; Solvent; Temperature; Concentration; Time; Industrial scale; Green chemistry; | 95% |
With sodium hydrogencarbonate In toluene; acetonitrile at 76℃; for 6h; Temperature; | 90.5% |
With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 16h; |
3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
paliperidone
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In methanol for 24h; Reflux; | 94% |
With N-ethyl-N,N-diisopropylamine In methanol Product distribution / selectivity; Reflux; | 93% |
With N-ethyl-N,N-diisopropylamine In methanol at 60℃; Reagent/catalyst; Inert atmosphere; | 90% |
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
Risperidone
Conditions | Yield |
---|---|
With sodium carbonate In methanol at 73 - 75℃; for 4 - 4.5h; Product distribution / selectivity; | 93.6% |
With sodium carbonate In water at 25 - 55℃; for 9h; Product distribution / selectivity; | |
With sodium carbonate In water; acetonitrile at 25 - 75℃; for 8h; Product distribution / selectivity; |
3-(2-chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
Risperidone
Conditions | Yield |
---|---|
With sodium carbonate In water at 110 - 120℃; for 0.666667h; Product distribution / selectivity; | 93.2% |
With sodium carbonate; potassium iodide In N,N-dimethyl-formamide at 80℃; for 10h; Temperature; | 76.9% |
N-tert-butoxycarbonyl-L-phenylalanine
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
C26H30FN3O4
Conditions | Yield |
---|---|
Stage #1: N-tert-butoxycarbonyl-L-phenylalanine With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride With 4-methyl-morpholine In N,N-dimethyl-formamide at 0 - 20℃; pH=8; | 92% |
Stage #1: N-tert-butoxycarbonyl-L-phenylalanine With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; pH=8; | 85% |
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
Conditions | Yield |
---|---|
With potassium carbonate; potassium iodide In acetonitrile at 75 - 78℃; Reagent/catalyst; | 92% |
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
2-chloropropionyl chloride
Conditions | Yield |
---|---|
With sodium hydroxide In dichloromethane; water at 0 - 20℃; for 5h; Large scale; | 91% |
N-tert-butoxycarbonyl-O-2,6-dichlorobenzyl-L-tyrosine
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
C33H34Cl2FN3O5
Conditions | Yield |
---|---|
Stage #1: N-tert-butoxycarbonyl-O-2,6-dichlorobenzyl-L-tyrosine With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride With 4-methyl-morpholine In N,N-dimethyl-formamide at 0 - 20℃; pH=8; | 90.9% |
Stage #1: N-tert-butoxycarbonyl-O-2,6-dichlorobenzyl-L-tyrosine With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; pH=8; | 84% |
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
Boc-Gly-Gly-Ala-Pro-OH
C29H39FN6O7
Conditions | Yield |
---|---|
Stage #1: Boc-Gly-Gly-Ala-Pro-OH With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride With 4-methyl-morpholine In N,N-dimethyl-formamide at 0 - 20℃; pH=8; | 90.5% |
8-(3-chloropropanoyl)-5,6-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-4(2H)-one
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
Conditions | Yield |
---|---|
With potassium carbonate; potassium iodide In acetonitrile Reflux; | 89.9% |
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
C36H52FN7O8
Conditions | Yield |
---|---|
Stage #1: Boc-Gly-Val-Gly-Val-Pro With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride With 4-methyl-morpholine In N,N-dimethyl-formamide at 0 - 20℃; pH=8; | 89.1% |
Boc-Glu(OBzl)-OH
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
C29H34FN3O6
Conditions | Yield |
---|---|
Stage #1: Boc-Glu(OBzl)-OH With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; pH=8; | 89% |
Boc-GFGFP-OH
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
C44H52FN7O8
Conditions | Yield |
---|---|
Stage #1: Boc-GFGFP-OH With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride With 4-methyl-morpholine In N,N-dimethyl-formamide at 0 - 20℃; pH=8; | 88.5% |
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
Boc-Gly-Gly-Phe-Pro-OH
C35H43FN6O7
Conditions | Yield |
---|---|
Stage #1: Boc-Gly-Gly-Phe-Pro-OH With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride With 4-methyl-morpholine In N,N-dimethyl-formamide at 0 - 20℃; pH=8; | 88.1% |
3-(2-iodoethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
Risperidone
Conditions | Yield |
---|---|
With potassium carbonate In acetone for 6h; Heating / reflux; | 87.4% |
Boc-Lys(Z)-OH
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
C31H39FN4O6
Conditions | Yield |
---|---|
Stage #1: Boc-Lys(Z)-OH With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; pH=8; | 87% |
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
Boc-Gly-Gly-Ile-Pro-OH
C32H45FN6O7
Conditions | Yield |
---|---|
Stage #1: Boc-Gly-Gly-Ile-Pro-OH With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride With 4-methyl-morpholine In N,N-dimethyl-formamide at 0 - 20℃; pH=8; | 86% |
BOC-glycine
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
C19H24FN3O4
Conditions | Yield |
---|---|
Stage #1: BOC-glycine With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0℃; for 0.25h; Stage #2: 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride With 4-methyl-morpholine In N,N-dimethyl-formamide at 0 - 20℃; pH=8; | 85% |
Boc-Lys(Boc)-OH
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
Conditions | Yield |
---|---|
Stage #1: Boc-Lys(Boc)-OH; 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; pH=8; Stage #2: With potassium hydrogencarbonate In water for 0.5h; Cooling with ice; | 85% |
4-(3-chloropropoxy)-3-methoxyacetophenone
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
Conditions | Yield |
---|---|
With potassium carbonate; potassium iodide In ethyl acetate; N,N-dimethyl-formamide at 80℃; for 50h; Inert atmosphere; | 84.65% |
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
toluene-4-sulfonic acid 2-(4-(3-piperidinopropoxy)phenyl)ethyl ester
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile for 6h; Reflux; | 83.2% |
tert-butyl 4-(2,4-difluorobenzoyl)piperidine-1-carboxylate
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
Conditions | Yield |
---|---|
With potassium carbonate In 1,4-dioxane at 90℃; | 83% |
4-(3-bromopropoxy)benzaldehyde
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile for 6h; Reflux; | 82.4% |
1-(tert-butoxycarbonyl)-L-proline
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
tert-butyl 2-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-carbonyl)pyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
Stage #1: 1-(tert-butoxycarbonyl)-L-proline With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0℃; for 0.25h; Stage #2: 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride With 4-methyl-morpholine In N,N-dimethyl-formamide at 0 - 20℃; pH=8; | 82% |
C11H14ClN3O2
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
C23H26FN5O3
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In methanol; N,N-dimethyl-formamide at 70 - 90℃; for 8h; Inert atmosphere; | 81.8% |
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
Conditions | Yield |
---|---|
Stage #1: rac-5-methanesulfonyl-2-(2,2,2-trifluoro-1-methylethoxy)benzoic acid With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 20℃; for 0.5h; Stage #2: 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride With triethylamine In dichloromethane at 20℃; | 81% |
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