Hunan Kaimir Biotechnology Co., Ltd. is a professional technology company specializing in the research and production of raw materials and intermediates. In 2017, it was recognized as a high-tech enterprise and a small technological innovation giant
Items Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------
Cas:130929-57-6
Min.Order:1 Gram
FOB Price: $100.0 / 500.0
Type:Trading Company
inquiryEntacapone CAS No.:130929-57-6 Name: Entacapone Synonyms: 2-Cyano-3-(5-dihydroxyamino-3,4-dioxo-1-cyclohexa-1,5-dienyl)-N,N-diethyl-prop-2-enamide Molecular Structure Mol
Cas:130929-57-6
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Other
inquiryhigh quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C
Cas:130929-57-6
Min.Order:1 Gram
Negotiable
Type:Manufacturers
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:130929-57-6
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:130929-57-6
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis
Cas:130929-57-6
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Lab/Research institutions
inquiryName:Entacapone CAS NO: 130929-57-6 Grade:Medical scientific research and export Molecular formula:C14H15N3O5 Molecular weight:305.286 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Da
Cas:130929-57-6
Min.Order:25 Kilogram
FOB Price: $2.0 / 3.0
Type:Other
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu
Cas:130929-57-6
Min.Order:1 Kilogram
FOB Price: $1.0 / 10.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:130929-57-6
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:130929-57-6
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiry130929-57-6;116314-67-1 Entacapone product Name Entacapone Synonyms 2-cyano-3-(5-dihydroxyamino-3,4-dioxo-1-cyclohexa-1,5-dienyl)-n,n-diethyl-
Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car
Appearance:White powder Storage:Room temperature Package:10G/Bottle,50G/Bottle Application:API Transportation:Express/air/sea Port:Any port in china
Cas:130929-57-6
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta
1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:130929-57-6
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:130929-57-6
Min.Order:1 Kilogram
FOB Price: $270.0 / 281.0
Type:Trading Company
inquiryEntacaponeCAS:130929-57-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,
Cas:130929-57-6
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,
Cas:130929-57-6
Min.Order:10 Gram
Negotiable
Type:Trading Company
inquiry1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi
Cas:130929-57-6
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:130929-57-6
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryAppearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By
Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other
Cas:130929-57-6
Min.Order:1 Kilogram
FOB Price: $3.0 / 5.0
Type:Trading Company
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
(E)-2-cyano-N,N-diethyl-3-(3-pivaloyloxy-4-hydroxy-5-nitrophenyl)propenamide
entacapone
Conditions | Yield |
---|---|
With phosphate buffer at 37℃; pH=7.4; Kinetics; | 100% |
(E)-2-cyano-N,N-diethyl-3-[3-t-butyloxycarbonyloxy-4-hydroxy-5-nitrophenyl]propenamide
entacapone
Conditions | Yield |
---|---|
With phosphate buffer at 37℃; pH=7.4; Kinetics; | 100% |
(2E)-2-cyano-3-(3-methoxy-4-hydroxy-5-nitro-phenyl)-N,Ndiethylprop-2-enamide
entacapone
Conditions | Yield |
---|---|
Stage #1: (2E)-2-cyano-3-(3-methoxy-4-hydroxy-5-nitro-phenyl)-N,Ndiethylprop-2-enamide With aluminum (III) chloride; triethylamine In dichloromethane at 0 - 5℃; for 3 - 4h; Heating / reflux; Stage #2: With hydrogenchloride In dichloromethane at 0 - 20℃; for 0.5h; | 98% |
With aluminum (III) chloride; triethylamine In dichloromethane | 98% |
Stage #1: (2E)-2-cyano-3-(3-methoxy-4-hydroxy-5-nitro-phenyl)-N,Ndiethylprop-2-enamide With aluminum (III) chloride; triethylamine In tetrahydrofuran at 0℃; Reflux; Stage #2: With hydrogenchloride In tetrahydrofuran; water for 6h; Solvent; Temperature; Time; Cooling; | 92% |
2-cyano-N,N-diethyl-3-(4-hydroxy-3-methoxy-5-nitrophenyl)prop-2-enamide
entacapone
Conditions | Yield |
---|---|
With pyridine; aluminum (III) chloride In dichloromethane at 0 - 45℃; for 2.5h; | 94.1% |
3,4-dimethoxy entacapone
entacapone
Conditions | Yield |
---|---|
Stage #1: 3,4-dimethoxy entacapone With aluminum (III) chloride In N,N-dimethyl-formamide at 5 - 80℃; for 15h; Stage #2: With hydrogenchloride; water In N,N-dimethyl-formamide at 5 - 30℃; for 2.5h; Product distribution / selectivity; | 92% |
Stage #1: 3,4-dimethoxy entacapone With pyridine; aluminum (III) chloride In N,N-dimethyl-formamide at 5 - 80℃; for 15h; Stage #2: With hydrogenchloride; water In N,N-dimethyl-formamide at 5 - 30℃; for 2h; Product distribution / selectivity; | 80% |
Stage #1: 3,4-dimethoxy entacapone With boron tribromide In dichloromethane at -15 - 20℃; Stage #2: With water In dichloromethane for 0.5h; Product distribution / selectivity; | 74% |
With aluminum (III) chloride In pyridine at 80℃; |
entacapone; piperidine salt
entacapone
Conditions | Yield |
---|---|
With hydrogenchloride In water; isopropyl alcohol at 20 - 30℃; | 91.1% |
entacapone
Conditions | Yield |
---|---|
With pyridine; aluminum (III) chloride In dichloromethane at 0 - 45℃; for 50h; | 87.3% |
entacapone
Conditions | Yield |
---|---|
With pyridine; aluminum (III) chloride In chloroform at 0℃; for 0.5h; Reflux; | 81.1% |
2-cyano-N,N-diethylacetamide
3,4-dihydroxy-5-nitrobenzaldehyde
entacapone
Conditions | Yield |
---|---|
Stage #1: 2-cyano-N,N-diethylacetamide; 3,4-dihydroxy-5-nitrobenzaldehyde With piperidine In 1,2-dimethoxyethane; n-heptane for 15 - 25h; Heating / reflux; Stage #2: In dichloromethane at 25 - 35℃; for 24h; Product distribution / selectivity; | 75% |
With piperidine In isopropyl alcohol for 12 - 15h; Heating / reflux; | 75.5% |
Stage #1: 2-cyano-N,N-diethylacetamide; 3,4-dihydroxy-5-nitrobenzaldehyde With acetic acid; diethylamine In toluene Knoevenagel Condensation; Stage #2: With hydrogen bromide In acetic acid; toluene at 20℃; | 73.8% |
2-cyano-N,N-diethylacetamide
3,4-dihydroxy-5-nitrobenzaldehyde
A
entacapone
B
(2Z)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide
Conditions | Yield |
---|---|
Stage #1: 2-cyano-N,N-diethylacetamide; 3,4-dihydroxy-5-nitrobenzaldehyde With piperidine In isopropyl alcohol for 12 - 15h; Heating / reflux; Stage #2: With acetic acid In isopropyl alcohol at 20℃; | A 75.5% B n/a |
piperidine; methylamine hydrochloride In butan-1-ol at 82℃; for 4 - 5h; Product distribution / selectivity; | |
piperidine; methylamine hydrochloride In i-Amyl alcohol at 89 - 90℃; for 3h; Product distribution / selectivity; |
entacapone
Conditions | Yield |
---|---|
Stage #1: 2-cyano-3-(3-hydroxy-4-methoxy-5-nitrophenyl)prop-2-eneamide With triethylamine In ethanol at 70 - 75℃; for 14h; Stage #2: With hydrogenchloride In water Time; | 55% |
(E)-2-cyano-N,N-diethyl-3-[3,4-bis(pivaloyloxymethoxy)-5-nitrophenyl]propenamide
entacapone
Conditions | Yield |
---|---|
With phosphate buffer at 37℃; for 4h; pH=7.4; Kinetics; | 20% |
(2Z)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide
entacapone
Conditions | Yield |
---|---|
With hydrogenchloride In water; toluene at 7 - 20℃; for 4h; Heating / reflux; | 14% |
entacapone
entacapone
Conditions | Yield |
---|---|
iodine In ethyl acetate for 10 - 12h; Product distribution / selectivity; Heating / reflux; Isomerisation; | |
With hydrogen bromide; acetic acid In water at 15 - 90℃; for 23 - 26h; | |
With hydrogen bromide; acetic acid at 90℃; |
3,4-dihydroxy-5-nitrobenzaldehyde
entacapone
Conditions | Yield |
---|---|
2.23 g (73%) |
2-cyano-N,N-diethyl-3-(4-hydroxy-3-methoxy-5-nitrophenyl)prop-2-enamide
A
entacapone
B
(2Z)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide
Conditions | Yield |
---|---|
With pyridine; aluminum (III) chloride In dichloromethane at 0 - 55℃; for 3.08333 - 4.25h; |
isonitrovanillin
entacapone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogen bromide / water / 4 h / Reflux 2: 1-methyl-piperazine / methanol / 20 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: piperidine; acetic acid / ethanol / 3 h / Reflux 2.1: N,N-dimethyl-formamide; bis(trichloromethyl) carbonate / chloroform / 2 h / Reflux 2.2: 2 h 3.1: aluminum (III) chloride; pyridine / chloroform / 0.5 h / 0 °C / Reflux View Scheme | |
Multi-step reaction with 4 steps 1: piperidine; acetic acid / ethanol / 3 h / Reflux 2: thionyl chloride / Reflux 3: ethyl acetate / Cooling with ice 4: aluminum (III) chloride; pyridine / chloroform / 0.5 h / 0 °C / Reflux View Scheme |
vanillin
entacapone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: nitric acid; acetic acid / 0 - 20 °C 2: hydrogen bromide / water / 4 h / Reflux 3: 1-methyl-piperazine / methanol / 20 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: acetic acid; diethylamine / toluene / Reflux 2: nitric acid 3: aluminum (III) chloride / N,N-dimethyl-formamide / 100 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: acetic acid; diethylamine / cyclohexane / Reflux 2.1: sodium nitrite; nitric acid / dichloromethane / 2 h / 20 °C 3.1: aluminum (III) chloride; triethylamine / tetrahydrofuran / 0 °C / Reflux 3.2: 6 h / Cooling View Scheme | |
Multi-step reaction with 3 steps 1.1: acetic acid; nitric acid / water / 4 h / 15 - 30 °C 2.1: tetrabutylammomium bromide; aluminum (III) chloride / dichloromethane / 0.5 h / 0 - 10 °C / Reflux 2.2: 25 h / 0 - 10 °C / Reflux 3.1: piperidine / isopropyl alcohol / 23 h / Reflux View Scheme |
3,4-dimethoxy-5-nitrobenzoyl chloride
entacapone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydride / tetrahydrofuran / -5 °C 2: sodium tris(acetoxy)borohydride / 45 °C 3: aluminum (III) chloride / pyridine / 80 °C View Scheme |
(2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)prop-2-enoic acid
entacapone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: thionyl chloride / 25 - 80 °C 2: diethylamine / dichloromethane / 2.33 h / -5 - 0 °C View Scheme |
(2E)-2-cyano-3-(3-methoxy-4-hydroxy-phenyl)-N,N-diethylprop-2-enamide
entacapone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: nitric acid 2: aluminum (III) chloride / N,N-dimethyl-formamide / 100 °C View Scheme |
entacapone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium tris(acetoxy)borohydride / 45 °C 2: aluminum (III) chloride / pyridine / 80 °C View Scheme |
(2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-2-propenoyl chloride
entacapone
Conditions | Yield |
---|---|
With diethylamine In dichloromethane at -5 - 0℃; for 2.33333h; |
2-cyano-N,N-diethylacetamide
entacapone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: acetic acid; diethylamine / toluene / Reflux 2: nitric acid 3: aluminum (III) chloride / N,N-dimethyl-formamide / 100 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: acetic acid; diethylamine / cyclohexane / Reflux 2.1: sodium nitrite; nitric acid / dichloromethane / 2 h / 20 °C 3.1: aluminum (III) chloride; triethylamine / tetrahydrofuran / 0 °C / Reflux 3.2: 6 h / Cooling View Scheme |
3,4-dihydroxy-5-nitrobenzaldehyde
entacapone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: piperidine; acetic acid / ethanol / 4 h / 80 °C 2: thionyl chloride / 25 - 80 °C 3: diethylamine / dichloromethane / 2.33 h / -5 - 0 °C View Scheme |
4,5-Dimethoxy-3-nitrobenzoic acid
entacapone
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: thionyl chloride / toluene / 60 °C 2: sodium hydride / tetrahydrofuran / -5 °C 3: sodium tris(acetoxy)borohydride / 45 °C 4: aluminum (III) chloride / pyridine / 80 °C View Scheme |
2-methoxy-4-iodophenol
entacapone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: triethylamine; tetrakis(triphenylphosphine) palladium(0); triphenylphosphine / N,N-dimethyl-formamide / 5 h / 95 - 100 °C / Inert atmosphere 2: nitric acid; acetic acid / 15 °C 3: pyridine; aluminum (III) chloride / dichloromethane / 0 - 45 °C View Scheme |
2-cyano-N,N-diethylacrylamide
entacapone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: triethylamine; tetrakis(triphenylphosphine) palladium(0); triphenylphosphine / N,N-dimethyl-formamide / 5 h / 95 - 100 °C / Inert atmosphere 2: nitric acid; acetic acid / 15 °C 3: pyridine; aluminum (III) chloride / dichloromethane / 0 - 45 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: IRA 96 resin / toluene / Reflux 2: triethylamine; ethanol / 12 h / 70 - 75 °C View Scheme |
butyryl chloride
entacapone
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 20℃; for 15h; | 93% |
Conditions | Yield |
---|---|
In ethanol at 25 - 30℃; | 92% |
entacapone
(2Z)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide
entacapone; sodium salt
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol; water at 20℃; | 87.1% |
(pivaloyloxy)acetic acid
entacapone
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In ethyl acetate at 20℃; | 85% |
Conditions | Yield |
---|---|
In ethanol at 25 - 30℃; | 80% |
Conditions | Yield |
---|---|
In ethanol at 25 - 30℃; | 78% |
Conditions | Yield |
---|---|
In ethanol at 25 - 30℃; | 77% |
In ethanol |
Conditions | Yield |
---|---|
In ethanol at 25 - 30℃; | 76% |
acetic anhydride
entacapone
Conditions | Yield |
---|---|
With sulfuric acid In ethyl acetate at 50℃; for 2h; | 74% |
di-tert-butyl dicarbonate
entacapone
(E)-2-cyano-N,N-diethyl-3-[3-t-butyloxycarbonyloxy-4-hydroxy-5-nitrophenyl]propenamide
Conditions | Yield |
---|---|
With 15-crown-5; sodium carbonate In tetrahydrofuran at 50℃; for 12h; | 64% |
iodomethyl pivaloate
entacapone
(E)-2-cyano-N,N-diethyl-3-[3,4-bis(pivaloyloxymethoxy)-5-nitrophenyl]propenamide
Conditions | Yield |
---|---|
With potassium carbonate In acetone at 20℃; | 56% |
entacapone
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃; | 52% |
2,2-dimethylpropanoic anhydride
entacapone
(E)-2-cyano-N,N-diethyl-3-(3-pivaloyloxy-4-hydroxy-5-nitrophenyl)propenamide
Conditions | Yield |
---|---|
With sulfuric acid at 50℃; for 2h; | 48% |
entacapone
Conditions | Yield |
---|---|
Stage #1: entacapone With pyridine; trichlorophosphate at 0 - 20℃; for 2h; phosphorylation; Stage #2: With sodium hydroxide In methanol Hydrolysis; | A n/a B 45% |
pivaloyl chloride
entacapone
Conditions | Yield |
---|---|
With pyridine; dmap at 20℃; for 15h; | 45% |
entacapone
Acetoxyacetyl chloride
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 20℃; for 15h; | 28% |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View