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HUNAN CHEMAPI BIOLOGICAL TECHNOLOGY CO.,LTD.

Hunan Kaimir Biotechnology Co., Ltd. is a professional technology company specializing in the research and production of raw materials and intermediates. In 2017, it was recognized as a high-tech enterprise and a small technological innovation giant

Entacapone

Cas:130929-57-6

Min.Order:1 Metric Ton

Negotiable

Type:Other

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------

High purity 130929-57-6 Entacapone

Cas:130929-57-6

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

Entacapone CAS No.:130929-57-6 Name: Entacapone Synonyms: 2-Cyano-3-(5-dihydroxyamino-3,4-dioxo-1-cyclohexa-1,5-dienyl)-N,N-diethyl-prop-2-enamide Molecular Structure Mol

High purity Entacapone CAS No.:130929-57-6

Cas:130929-57-6

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

Entacapone (150 mg)

Cas:130929-57-6

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Entacapone manufacturer with low price

Cas:130929-57-6

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Entacapone

Cas:130929-57-6

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Entacapone 130929-57-6 GMP Manufacturer

Cas:130929-57-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Entacapone

Cas:130929-57-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

Entacapone

Cas:130929-57-6

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

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Hubei DiBo chemical co., LTD

Name:Entacapone CAS NO: 130929-57-6 Grade:Medical scientific research and export Molecular formula:C14H15N3O5 Molecular weight:305.286 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Da

Entacapone/ CAS:130929-57-6/ Entacapone raw material/ high-quality

Cas:130929-57-6

Min.Order:25 Kilogram

FOB Price: $2.0 / 3.0

Type:Other

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu

Entacapone CAS 130929-57-6 for Anti-Parkinsonian

Cas:130929-57-6

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 130929-57-6 with best quality

Cas:130929-57-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

TIANFUCHEM--130929-57-6--Entacapone

Cas:130929-57-6

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Henan Sinotech Import&Export Corporation

130929-57-6;116314-67-1 Entacapone product Name Entacapone Synonyms 2-cyano-3-(5-dihydroxyamino-3,4-dioxo-1-cyclohexa-1,5-dienyl)-n,n-diethyl-

130929-57-6 Entacapone

Cas:130929-57-6

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Other

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Hebei yanxi chemical co.,LTD.

Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car

Entacapone

Cas:130929-57-6

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Manufacturers

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:White powder Storage:Room temperature Package:10G/Bottle,50G/Bottle Application:API Transportation:Express/air/sea Port:Any port in china

High Quality 99% Entacopone CAS:130929-57-6

Cas:130929-57-6

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

Entacapone cas 130929-57-6

Cas:130929-57-6

Min.Order:10 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2-Propenamide,2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-, (2E)- 130929-57-6

Cas:130929-57-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Parkinson's disease, Entacapone CAS:130929-57-6

Cas:130929-57-6

Min.Order:1 Kilogram

FOB Price: $270.0 / 281.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

EntacaponeCAS:130929-57-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

EntacaponeCAS:130929-57-6

Cas:130929-57-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Entacapone

Cas:130929-57-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,

Entacapone CAS NO.130929-57-6

Cas:130929-57-6

Min.Order:10 Gram

Negotiable

Type:Trading Company

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Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi

factory supply fresh 99% Entacapone with cas 130929-57-6 in stock

Cas:130929-57-6

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2-Propenamide,2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-, (2E)-

Cas:130929-57-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

Entacapone

Cas:130929-57-6

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Entacapone

Cas:130929-57-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

99% Entacapone CAS 130929-57-6 with Best Price

Cas:130929-57-6

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Entacapone

Cas:130929-57-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Entacapone

Cas:130929-57-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

Entacapone

Cas:130929-57-6

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

(E)-2-cyano-N,N-diethyl-3-(3-pivaloyloxy-4-hydroxy-5-nitrophenyl)propenamide
345317-61-5

(E)-2-cyano-N,N-diethyl-3-(3-pivaloyloxy-4-hydroxy-5-nitrophenyl)propenamide

entacapone
130929-57-6

entacapone

Conditions
ConditionsYield
With phosphate buffer at 37℃; pH=7.4; Kinetics;100%
(E)-2-cyano-N,N-diethyl-3-[3-t-butyloxycarbonyloxy-4-hydroxy-5-nitrophenyl]propenamide
404860-98-6

(E)-2-cyano-N,N-diethyl-3-[3-t-butyloxycarbonyloxy-4-hydroxy-5-nitrophenyl]propenamide

entacapone
130929-57-6

entacapone

Conditions
ConditionsYield
With phosphate buffer at 37℃; pH=7.4; Kinetics;100%
(2E)-2-cyano-3-(3-methoxy-4-hydroxy-5-nitro-phenyl)-N,Ndiethylprop-2-enamide
857629-78-8

(2E)-2-cyano-3-(3-methoxy-4-hydroxy-5-nitro-phenyl)-N,Ndiethylprop-2-enamide

entacapone
130929-57-6

entacapone

Conditions
ConditionsYield
Stage #1: (2E)-2-cyano-3-(3-methoxy-4-hydroxy-5-nitro-phenyl)-N,Ndiethylprop-2-enamide With aluminum (III) chloride; triethylamine In dichloromethane at 0 - 5℃; for 3 - 4h; Heating / reflux;
Stage #2: With hydrogenchloride In dichloromethane at 0 - 20℃; for 0.5h;
98%
With aluminum (III) chloride; triethylamine In dichloromethane98%
Stage #1: (2E)-2-cyano-3-(3-methoxy-4-hydroxy-5-nitro-phenyl)-N,Ndiethylprop-2-enamide With aluminum (III) chloride; triethylamine In tetrahydrofuran at 0℃; Reflux;
Stage #2: With hydrogenchloride In tetrahydrofuran; water for 6h; Solvent; Temperature; Time; Cooling;
92%
2-cyano-N,N-diethyl-3-(4-hydroxy-3-methoxy-5-nitrophenyl)prop-2-enamide
146698-91-1

2-cyano-N,N-diethyl-3-(4-hydroxy-3-methoxy-5-nitrophenyl)prop-2-enamide

entacapone
130929-57-6

entacapone

Conditions
ConditionsYield
With pyridine; aluminum (III) chloride In dichloromethane at 0 - 45℃; for 2.5h;94.1%
3,4-dimethoxy entacapone
1067233-93-5

3,4-dimethoxy entacapone

entacapone
130929-57-6

entacapone

Conditions
ConditionsYield
Stage #1: 3,4-dimethoxy entacapone With aluminum (III) chloride In N,N-dimethyl-formamide at 5 - 80℃; for 15h;
Stage #2: With hydrogenchloride; water In N,N-dimethyl-formamide at 5 - 30℃; for 2.5h; Product distribution / selectivity;
92%
Stage #1: 3,4-dimethoxy entacapone With pyridine; aluminum (III) chloride In N,N-dimethyl-formamide at 5 - 80℃; for 15h;
Stage #2: With hydrogenchloride; water In N,N-dimethyl-formamide at 5 - 30℃; for 2h; Product distribution / selectivity;
80%
Stage #1: 3,4-dimethoxy entacapone With boron tribromide In dichloromethane at -15 - 20℃;
Stage #2: With water In dichloromethane for 0.5h; Product distribution / selectivity;
74%
With aluminum (III) chloride In pyridine at 80℃;
entacapone; piperidine salt
1047659-01-7

entacapone; piperidine salt

entacapone
130929-57-6

entacapone

Conditions
ConditionsYield
With hydrogenchloride In water; isopropyl alcohol at 20 - 30℃;91.1%
N,N-diethyl-2-cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)acrylamide

N,N-diethyl-2-cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)acrylamide

entacapone
130929-57-6

entacapone

Conditions
ConditionsYield
With pyridine; aluminum (III) chloride In dichloromethane at 0 - 45℃; for 50h;87.3%
C15H16N3O5(1-)*C4H12N(1+)

C15H16N3O5(1-)*C4H12N(1+)

entacapone
130929-57-6

entacapone

Conditions
ConditionsYield
With pyridine; aluminum (III) chloride In chloroform at 0℃; for 0.5h; Reflux;81.1%
2-cyano-N,N-diethylacetamide
26391-06-0

2-cyano-N,N-diethylacetamide

3,4-dihydroxy-5-nitrobenzaldehyde
116313-85-0

3,4-dihydroxy-5-nitrobenzaldehyde

entacapone
130929-57-6

entacapone

Conditions
ConditionsYield
Stage #1: 2-cyano-N,N-diethylacetamide; 3,4-dihydroxy-5-nitrobenzaldehyde With piperidine In 1,2-dimethoxyethane; n-heptane for 15 - 25h; Heating / reflux;
Stage #2: In dichloromethane at 25 - 35℃; for 24h; Product distribution / selectivity;
75%
With piperidine In isopropyl alcohol for 12 - 15h; Heating / reflux;75.5%
Stage #1: 2-cyano-N,N-diethylacetamide; 3,4-dihydroxy-5-nitrobenzaldehyde With acetic acid; diethylamine In toluene Knoevenagel Condensation;
Stage #2: With hydrogen bromide In acetic acid; toluene at 20℃;
73.8%
2-cyano-N,N-diethylacetamide
26391-06-0

2-cyano-N,N-diethylacetamide

3,4-dihydroxy-5-nitrobenzaldehyde
116313-85-0

3,4-dihydroxy-5-nitrobenzaldehyde

A

entacapone
130929-57-6

entacapone

B

(2Z)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide
145195-63-7

(2Z)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide

Conditions
ConditionsYield
Stage #1: 2-cyano-N,N-diethylacetamide; 3,4-dihydroxy-5-nitrobenzaldehyde With piperidine In isopropyl alcohol for 12 - 15h; Heating / reflux;
Stage #2: With acetic acid In isopropyl alcohol at 20℃;
A 75.5%
B n/a
piperidine; methylamine hydrochloride In butan-1-ol at 82℃; for 4 - 5h; Product distribution / selectivity;
piperidine; methylamine hydrochloride In i-Amyl alcohol at 89 - 90℃; for 3h; Product distribution / selectivity;
2-cyano-3-(3-hydroxy-4-methoxy-5-nitrophenyl)prop-2-eneamide

2-cyano-3-(3-hydroxy-4-methoxy-5-nitrophenyl)prop-2-eneamide

entacapone
130929-57-6

entacapone

Conditions
ConditionsYield
Stage #1: 2-cyano-3-(3-hydroxy-4-methoxy-5-nitrophenyl)prop-2-eneamide With triethylamine In ethanol at 70 - 75℃; for 14h;
Stage #2: With hydrogenchloride In water Time;
55%
(E)-2-cyano-N,N-diethyl-3-[3,4-bis(pivaloyloxymethoxy)-5-nitrophenyl]propenamide
404860-97-5

(E)-2-cyano-N,N-diethyl-3-[3,4-bis(pivaloyloxymethoxy)-5-nitrophenyl]propenamide

entacapone
130929-57-6

entacapone

Conditions
ConditionsYield
With phosphate buffer at 37℃; for 4h; pH=7.4; Kinetics;20%
(2Z)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide
145195-63-7

(2Z)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide

entacapone
130929-57-6

entacapone

Conditions
ConditionsYield
With hydrogenchloride In water; toluene at 7 - 20℃; for 4h; Heating / reflux;14%
entacapone
686349-59-7

entacapone

entacapone
130929-57-6

entacapone

Conditions
ConditionsYield
iodine In ethyl acetate for 10 - 12h; Product distribution / selectivity; Heating / reflux; Isomerisation;
With hydrogen bromide; acetic acid In water at 15 - 90℃; for 23 - 26h;
With hydrogen bromide; acetic acid at 90℃;
N,N-Hydrochloric diethylcyanoacetamide

N,N-Hydrochloric diethylcyanoacetamide

3,4-dihydroxy-5-nitrobenzaldehyde
116313-85-0

3,4-dihydroxy-5-nitrobenzaldehyde

entacapone
130929-57-6

entacapone

Conditions
ConditionsYield
2.23 g (73%)
2-cyano-N,N-diethyl-3-(4-hydroxy-3-methoxy-5-nitrophenyl)prop-2-enamide
146698-91-1

2-cyano-N,N-diethyl-3-(4-hydroxy-3-methoxy-5-nitrophenyl)prop-2-enamide

A

entacapone
130929-57-6

entacapone

B

(2Z)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide
145195-63-7

(2Z)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide

Conditions
ConditionsYield
With pyridine; aluminum (III) chloride In dichloromethane at 0 - 55℃; for 3.08333 - 4.25h;
isonitrovanillin
6635-20-7

isonitrovanillin

entacapone
130929-57-6

entacapone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogen bromide / water / 4 h / Reflux
2: 1-methyl-piperazine / methanol / 20 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: piperidine; acetic acid / ethanol / 3 h / Reflux
2.1: N,N-dimethyl-formamide; bis(trichloromethyl) carbonate / chloroform / 2 h / Reflux
2.2: 2 h
3.1: aluminum (III) chloride; pyridine / chloroform / 0.5 h / 0 °C / Reflux
View Scheme
Multi-step reaction with 4 steps
1: piperidine; acetic acid / ethanol / 3 h / Reflux
2: thionyl chloride / Reflux
3: ethyl acetate / Cooling with ice
4: aluminum (III) chloride; pyridine / chloroform / 0.5 h / 0 °C / Reflux
View Scheme
vanillin
121-33-5

vanillin

entacapone
130929-57-6

entacapone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: nitric acid; acetic acid / 0 - 20 °C
2: hydrogen bromide / water / 4 h / Reflux
3: 1-methyl-piperazine / methanol / 20 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: acetic acid; diethylamine / toluene / Reflux
2: nitric acid
3: aluminum (III) chloride / N,N-dimethyl-formamide / 100 °C
View Scheme
Multi-step reaction with 3 steps
1.1: acetic acid; diethylamine / cyclohexane / Reflux
2.1: sodium nitrite; nitric acid / dichloromethane / 2 h / 20 °C
3.1: aluminum (III) chloride; triethylamine / tetrahydrofuran / 0 °C / Reflux
3.2: 6 h / Cooling
View Scheme
Multi-step reaction with 3 steps
1.1: acetic acid; nitric acid / water / 4 h / 15 - 30 °C
2.1: tetrabutylammomium bromide; aluminum (III) chloride / dichloromethane / 0.5 h / 0 - 10 °C / Reflux
2.2: 25 h / 0 - 10 °C / Reflux
3.1: piperidine / isopropyl alcohol / 23 h / Reflux
View Scheme
3,4-dimethoxy-5-nitrobenzoyl chloride
134610-30-3

3,4-dimethoxy-5-nitrobenzoyl chloride

entacapone
130929-57-6

entacapone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydride / tetrahydrofuran / -5 °C
2: sodium tris(acetoxy)borohydride / 45 °C
3: aluminum (III) chloride / pyridine / 80 °C
View Scheme
(2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)prop-2-enoic acid
160391-70-8

(2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)prop-2-enoic acid

entacapone
130929-57-6

entacapone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: thionyl chloride / 25 - 80 °C
2: diethylamine / dichloromethane / 2.33 h / -5 - 0 °C
View Scheme
(2E)-2-cyano-3-(3-methoxy-4-hydroxy-phenyl)-N,N-diethylprop-2-enamide
893419-47-1

(2E)-2-cyano-3-(3-methoxy-4-hydroxy-phenyl)-N,N-diethylprop-2-enamide

entacapone
130929-57-6

entacapone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: nitric acid
2: aluminum (III) chloride / N,N-dimethyl-formamide / 100 °C
View Scheme
2-cyano-3-(3,4-dimethoxy-5-nitrophenyl)-3-hydroxy-N,N-diethyl-prop-2-enamide

2-cyano-3-(3,4-dimethoxy-5-nitrophenyl)-3-hydroxy-N,N-diethyl-prop-2-enamide

entacapone
130929-57-6

entacapone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium tris(acetoxy)borohydride / 45 °C
2: aluminum (III) chloride / pyridine / 80 °C
View Scheme
(2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-2-propenoyl chloride
1291066-63-1

(2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-2-propenoyl chloride

entacapone
130929-57-6

entacapone

Conditions
ConditionsYield
With diethylamine In dichloromethane at -5 - 0℃; for 2.33333h;
2-cyano-N,N-diethylacetamide
26391-06-0

2-cyano-N,N-diethylacetamide

entacapone
130929-57-6

entacapone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: acetic acid; diethylamine / toluene / Reflux
2: nitric acid
3: aluminum (III) chloride / N,N-dimethyl-formamide / 100 °C
View Scheme
Multi-step reaction with 3 steps
1.1: acetic acid; diethylamine / cyclohexane / Reflux
2.1: sodium nitrite; nitric acid / dichloromethane / 2 h / 20 °C
3.1: aluminum (III) chloride; triethylamine / tetrahydrofuran / 0 °C / Reflux
3.2: 6 h / Cooling
View Scheme
3,4-dihydroxy-5-nitrobenzaldehyde
116313-85-0

3,4-dihydroxy-5-nitrobenzaldehyde

entacapone
130929-57-6

entacapone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: piperidine; acetic acid / ethanol / 4 h / 80 °C
2: thionyl chloride / 25 - 80 °C
3: diethylamine / dichloromethane / 2.33 h / -5 - 0 °C
View Scheme
4,5-Dimethoxy-3-nitrobenzoic acid
91004-48-7

4,5-Dimethoxy-3-nitrobenzoic acid

entacapone
130929-57-6

entacapone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: thionyl chloride / toluene / 60 °C
2: sodium hydride / tetrahydrofuran / -5 °C
3: sodium tris(acetoxy)borohydride / 45 °C
4: aluminum (III) chloride / pyridine / 80 °C
View Scheme
2-methoxy-4-iodophenol
203861-62-5

2-methoxy-4-iodophenol

entacapone
130929-57-6

entacapone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine; tetrakis(triphenylphosphine) palladium(0); triphenylphosphine / N,N-dimethyl-formamide / 5 h / 95 - 100 °C / Inert atmosphere
2: nitric acid; acetic acid / 15 °C
3: pyridine; aluminum (III) chloride / dichloromethane / 0 - 45 °C
View Scheme
2-cyano-N,N-diethylacrylamide
53793-77-4

2-cyano-N,N-diethylacrylamide

entacapone
130929-57-6

entacapone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine; tetrakis(triphenylphosphine) palladium(0); triphenylphosphine / N,N-dimethyl-formamide / 5 h / 95 - 100 °C / Inert atmosphere
2: nitric acid; acetic acid / 15 °C
3: pyridine; aluminum (III) chloride / dichloromethane / 0 - 45 °C
View Scheme
isonitrovanillin
6635-20-7

isonitrovanillin

2-cyano-N,N-diethylacetamide
26391-06-0

2-cyano-N,N-diethylacetamide

entacapone
130929-57-6

entacapone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: IRA 96 resin / toluene / Reflux
2: triethylamine; ethanol / 12 h / 70 - 75 °C
View Scheme
butyryl chloride
141-75-3

butyryl chloride

entacapone
130929-57-6

entacapone

(E)-2-cyano-N,N-diethyl-3-[3,4-dibutyryloxy-5-nitrophenyl]propenamide

(E)-2-cyano-N,N-diethyl-3-[3,4-dibutyryloxy-5-nitrophenyl]propenamide

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃; for 15h;93%
diethylamine
109-89-7

diethylamine

entacapone
130929-57-6

entacapone

C14H15N3O5*C4H11N

C14H15N3O5*C4H11N

Conditions
ConditionsYield
In ethanol at 25 - 30℃;92%
entacapone
130929-57-6

entacapone

(2Z)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide
145195-63-7

(2Z)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide

entacapone; sodium salt
1047659-02-8

entacapone; sodium salt

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water at 20℃;87.1%
(pivaloyloxy)acetic acid
89941-82-2

(pivaloyloxy)acetic acid

entacapone
130929-57-6

entacapone

(E)-2-cyano-N,N-diethyl-3-[3,4-bis(pivaloyloxyacetyloxy)-5-nitrophenyl]propenamide

(E)-2-cyano-N,N-diethyl-3-[3,4-bis(pivaloyloxyacetyloxy)-5-nitrophenyl]propenamide

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In ethyl acetate at 20℃;85%
N-ethyl-N,N-diisopropylamine
7087-68-5

N-ethyl-N,N-diisopropylamine

entacapone
130929-57-6

entacapone

C14H15N3O5*C8H19N

C14H15N3O5*C8H19N

Conditions
ConditionsYield
In ethanol at 25 - 30℃;80%
triethylamine
121-44-8

triethylamine

entacapone
130929-57-6

entacapone

C14H15N3O5*C6H15N

C14H15N3O5*C6H15N

Conditions
ConditionsYield
In ethanol at 25 - 30℃;78%
piperidine
110-89-4

piperidine

entacapone
130929-57-6

entacapone

entacapone; piperidine salt
1047659-01-7

entacapone; piperidine salt

Conditions
ConditionsYield
In ethanol at 25 - 30℃;77%
In ethanol
morpholine
110-91-8

morpholine

entacapone
130929-57-6

entacapone

C14H15N3O5*C4H9NO

C14H15N3O5*C4H9NO

Conditions
ConditionsYield
In ethanol at 25 - 30℃;76%
acetic anhydride
108-24-7

acetic anhydride

entacapone
130929-57-6

entacapone

(E)-2-cyano-N,N-diethyl-3-(3,4-diacetyloxy-5-nitrophenyl)propenamide

(E)-2-cyano-N,N-diethyl-3-(3,4-diacetyloxy-5-nitrophenyl)propenamide

Conditions
ConditionsYield
With sulfuric acid In ethyl acetate at 50℃; for 2h;74%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

entacapone
130929-57-6

entacapone

(E)-2-cyano-N,N-diethyl-3-[3-t-butyloxycarbonyloxy-4-hydroxy-5-nitrophenyl]propenamide
404860-98-6

(E)-2-cyano-N,N-diethyl-3-[3-t-butyloxycarbonyloxy-4-hydroxy-5-nitrophenyl]propenamide

Conditions
ConditionsYield
With 15-crown-5; sodium carbonate In tetrahydrofuran at 50℃; for 12h;64%
iodomethyl pivaloate
53064-79-2

iodomethyl pivaloate

entacapone
130929-57-6

entacapone

(E)-2-cyano-N,N-diethyl-3-[3,4-bis(pivaloyloxymethoxy)-5-nitrophenyl]propenamide
404860-97-5

(E)-2-cyano-N,N-diethyl-3-[3,4-bis(pivaloyloxymethoxy)-5-nitrophenyl]propenamide

Conditions
ConditionsYield
With potassium carbonate In acetone at 20℃;56%
entacapone
130929-57-6

entacapone

(valeroyloxy)acetic acid

(valeroyloxy)acetic acid

(E)-2-cyano-N,N-diethyl-3-[3,4-bis(valeryloxyacetyloxy)-5-nitrophenyl]propenamide

(E)-2-cyano-N,N-diethyl-3-[3,4-bis(valeryloxyacetyloxy)-5-nitrophenyl]propenamide

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃;52%
2,2-dimethylpropanoic anhydride
1538-75-6

2,2-dimethylpropanoic anhydride

entacapone
130929-57-6

entacapone

(E)-2-cyano-N,N-diethyl-3-(3-pivaloyloxy-4-hydroxy-5-nitrophenyl)propenamide
345317-61-5

(E)-2-cyano-N,N-diethyl-3-(3-pivaloyloxy-4-hydroxy-5-nitrophenyl)propenamide

Conditions
ConditionsYield
With sulfuric acid at 50℃; for 2h;48%
entacapone
130929-57-6

entacapone

A

2-cyano-N,N-diethyl-3-(2-hydroxy-7-nitro-2-oxo-2λ5-benzo[1,3,2]dioxaphosphol-5-yl)-acrylamide

2-cyano-N,N-diethyl-3-(2-hydroxy-7-nitro-2-oxo-2λ5-benzo[1,3,2]dioxaphosphol-5-yl)-acrylamide

B

C14H13N3O8P(3-)*3Na(1+)

C14H13N3O8P(3-)*3Na(1+)

Conditions
ConditionsYield
Stage #1: entacapone With pyridine; trichlorophosphate at 0 - 20℃; for 2h; phosphorylation;
Stage #2: With sodium hydroxide In methanol Hydrolysis;
A n/a
B 45%
pivaloyl chloride
3282-30-2

pivaloyl chloride

entacapone
130929-57-6

entacapone

(E)-2-cyano-N,N-diethyl-3-[3,4-dipivaloyloxy-5-nitrophenyl]propenamide

(E)-2-cyano-N,N-diethyl-3-[3,4-dipivaloyloxy-5-nitrophenyl]propenamide

Conditions
ConditionsYield
With pyridine; dmap at 20℃; for 15h;45%
entacapone
130929-57-6

entacapone

Acetoxyacetyl chloride
13831-31-7

Acetoxyacetyl chloride

(E)-2-cyano-N,N-diethyl-3-[3,4-bis(acetoxyacetyloxy)-5-nitrophenyl]propenamide

(E)-2-cyano-N,N-diethyl-3-[3,4-bis(acetoxyacetyloxy)-5-nitrophenyl]propenamide

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃; for 15h;28%

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