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(1S,4R)-2-Azabicyclo[2.2.1]hept-5-en-3-one cas 130931-83-8Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express
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inquirygood quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:250mg Application:Pharma;Industry;Agricultural;chemical reaserch Transportation:by express or by sea Port:Any po
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(1S,4R)-N-hydroxymethyl-2-azabicyclo<2.2.1>hept-5-en-3-one
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
Conditions | Yield |
---|---|
With ammonium hydroxide In methanol at 20℃; for 4h; | 95% |
With ammonium hydroxide In methanol for 12h; Ambient temperature; | 45% |
With methanol; ammonium hydroxide for 13h; Ambient temperature; | 38% |
racemic 2-azabicyclo[2.2.1]hept-5-en-3-one
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
Conditions | Yield |
---|---|
With resin-supported recombinant Candida antarctica lipase B; water In tert-butyl methyl ether at 60℃; for 102h; enantioselective reaction; | 48% |
With citrophilla (ATCC No.21285) In phosphate buffer for 24h; pH=7.5; | 31.8% |
With lipase B Candida antarctica recombined fromAspergillus oryzae In aq. phosphate buffer for 168h; Reagent/catalyst; Enzymatic reaction; | n/a |
Multi-step reaction with 3 steps 1: Sonication 2: water; lipase B from Candida antarctica; benzylamine / isopropyl alcohol / 0.5 h / 60 °C / Enzymatic reaction 3: ammonium hydroxide / methanol / 4 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: Sonication 2: water; lipase B from Candida antarctica; benzylamine / isopropyl alcohol / 2 h / 60 °C / Enzymatic reaction 3: ammonium hydroxide / methanol / 4 h / 20 °C View Scheme |
racemic 2-azabicyclo[2.2.1]hept-5-en-3-one
A
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
B
(-)-(1S, 4R)-4-amino-2-cyclopentene-1-carboxylic acid
Conditions | Yield |
---|---|
With lipase B from Candida antarctica In water; isopropyl alcohol at 60℃; for 4h; Enzymatic reaction; stereospecific reaction; | A 46% B 48% |
With water In tert-butyl methyl ether Enzymatic reaction; optical yield given as %ee; |
(1S,4R)-2-[(4-methoxyphenyl)methyl]-2-azabicyclo[2.2.1]hept-5-en-3-one
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
Conditions | Yield |
---|---|
With ammonium cerium(IV) nitrate In water; acetonitrile at 0℃; for 2.5h; | 26% |
2-azabicyclo[2.2.1.]hept-5-en-3-one
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
A
(3aS,7aR)-3a,4,7,7a-tetrahydroisobenzofuran-1(3H)-one
B
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
Conditions | Yield |
---|---|
With sodium tetrahydroborate; camphor-10-sulfonic acid 1.) THF, EtOH, -40 degC, 3 h; 2.) toluene, reflux, 5 h; Yield given. Multistep reaction; |
2-azabicyclo[2.2.1.]hept-5-en-3-one
A
(-)-2-azabicyclo[2.2.1]hept-5-en-3-one
B
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
Conditions | Yield |
---|---|
With brucine In methanol at 20℃; for 6h; | |
With Methylobacterium sp. Y1-6 at 30℃; for 24h; Overall yield = 19 %Chromat.; | A n/a B n/a |
With malonamidase E2 (MAE2) In aq. phosphate buffer at 30℃; for 24h; pH=7.5; Resolution of racemate; Enzymatic reaction; | A n/a B n/a |
With Cu-(R)-2,2'-dihydroxy-1,1'-binaphthalene-6,6'-dicarboxylic acid organic framework silica composite In ethanol; hexane Resolution of racemate; |
2-hydroxymethyl-2-azabicyclo<2.2.1>hept-5-en-3-one
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 2: 45 percent / aq. NH3 / methanol / 12 h / Ambient temperature View Scheme | |
Multi-step reaction with 2 steps 2: 38 percent / Nh4OH, MeOH / 13 h / Ambient temperature View Scheme |
(1S,6R)-6-(isopropoxycarbonyl)cyclohex-3-enecarboxylic acid
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: CH2Cl2 / 3 h / Ambient temperature 2: 1.) NaBH4; 2.) camphorsulfonic acid / 1.) THF, EtOH, -40 degC, 3 h; 2.) toluene, reflux, 5 h View Scheme |
cis-1,2,3,6-tetrahydrophthalic anhydride
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) TADDOL / 1.) Et2O, r.t., 3 h; 2.) THF, -20 degC, 10 d 2: CH2Cl2 / 3 h / Ambient temperature 3: 1.) NaBH4; 2.) camphorsulfonic acid / 1.) THF, EtOH, -40 degC, 3 h; 2.) toluene, reflux, 5 h View Scheme |
2-azabicyclo[2.2.1.]hept-5-en-3-one
A
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
B
(-)-(1S, 4R)-4-amino-2-cyclopentene-1-carboxylic acid
Conditions | Yield |
---|---|
With water In tert-butyl methyl ether Enzymatic reaction; optical yield given as %ee; enantioselective reaction; | |
With Bradyrhizobium japonicum USDA 6 (−)-γ-lactamase In aq. buffer at 50℃; pH=6; Kinetics; Temperature; pH-value; Concentration; Enzymatic reaction; enantioselective reaction; | A n/a B n/a |
With cyclic imide hydrolase(CIH) In aq. phosphate buffer at 30℃; for 24h; pH=7.5; Resolution of racemate; Enzymatic reaction; | A n/a B n/a |
2-azabicyclo[2.2.1.]hept-5-en-3-one
A
(-)-2-azabicyclo[2.2.1]hept-5-en-3-one
B
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
C
(1R,4S)-4-aminocyclopenten-2-ene-1-carboxylic acid
Conditions | Yield |
---|---|
With Nocardia farcinica-polyamidase (NfpolyA) In aq. phosphate buffer at 30℃; for 24h; pH=7.5; Resolution of racemate; Enzymatic reaction; | A n/a B n/a C n/a |
2-azabicyclo[2.2.1.]hept-5-en-3-one
A
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
B
(1R,4S)-4-aminocyclopenten-2-ene-1-carboxylic acid
C
(-)-(1S, 4R)-4-amino-2-cyclopentene-1-carboxylic acid
Conditions | Yield |
---|---|
With non-heme chloroperoxidase (CPO-T) In aq. phosphate buffer at 30℃; for 24h; pH=7.5; Resolution of racemate; Enzymatic reaction; | A n/a B n/a C n/a |
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: water; lipase B from Candida antarctica; benzylamine / isopropyl alcohol / 0.5 h / 60 °C / Enzymatic reaction 2: ammonium hydroxide / methanol / 4 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: water; lipase B from Candida antarctica; benzylamine / isopropyl alcohol / 2 h / 60 °C / Enzymatic reaction 2: ammonium hydroxide / methanol / 4 h / 20 °C View Scheme |
racemic 2-azabicyclo[2.2.1]hept-5-en-3-one
A
(-)-2-azabicyclo[2.2.1]hept-5-en-3-one
B
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
C
(-)-(1S, 4R)-4-amino-2-cyclopentene-1-carboxylic acid
Conditions | Yield |
---|---|
With water; lipase B from Candida antarctica In isopropyl alcohol at 60℃; for 0.5h; Enzymatic reaction; | A n/a B n/a C n/a |
2-azabicyclo[2.2.1.]hept-5-en-3-one
B
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
Conditions | Yield |
---|---|
With chloroperoxidase In aq. phosphate buffer at 30℃; for 0.5h; pH=7; Kinetics; Reagent/catalyst; Temperature; Solvent; pH-value; Resolution of racemate; Green chemistry; Enzymatic reaction; enantioselective reaction; | A n/a B 2.1 g |
2-azabicyclo[2.2.1.]hept-5-en-3-one
B
(-)-2-azabicyclo[2.2.1]hept-5-en-3-one
C
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
Conditions | Yield |
---|---|
With CfGL2 In aq. phosphate buffer at 30℃; for 9h; pH=7; Resolution of racemate; Green chemistry; Enzymatic reaction; enantioselective reaction; | A n/a B n/a C n/a |
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: triethylamine; methanol; lithium hydroxide; water / -20 °C / pH 6 - 7 2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 18 h / 45 °C View Scheme |
(-)-(1S, 4R)-4-amino-2-cyclopentene-1-carboxylic acid
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
Conditions | Yield |
---|---|
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate In N,N-dimethyl-formamide at 45℃; for 18h; | n/a |
racemic 2-azabicyclo[2.2.1]hept-5-en-3-one
A
(-)-2-azabicyclo[2.2.1]hept-5-en-3-one
B
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
cis-4-amino-cyclopent-2-ene-1-carboxylic acid
Conditions | Yield |
---|---|
With (+) γ-lactamase immobilized on epoxy graphene oxide carrier In aq. phosphate buffer at 80℃; pH=8; Kinetics; Reagent/catalyst; Enzymatic reaction; |
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
Conditions | Yield |
---|---|
With sodium hydroxide In water; acetic acid |
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
(-)-2-Azabicyclo<2.2.1>heptan-3-one
Conditions | Yield |
---|---|
With hydrogen; palladium 10% on activated carbon In ethyl acetate at 20℃; for 24h; | 100% |
With hydrogen; palladium 10% on activated carbon In ethyl acetate at 20℃; for 24h; | 100% |
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; for 2h; | 98% |
di-tert-butyl dicarbonate
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
(-)-[(1R,4S)-tert-butyl 3-oxo-2-azabicyclo(2.2.1)hept-5-ene-2-carboxylate]
Conditions | Yield |
---|---|
With dmap; triethylamine In tetrahydrofuran | 100% |
With pyridine; dmap at 20℃; for 3h; | 100% |
With dmap; triethylamine In tetrahydrofuran at 0 - 20℃; | 93% |
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
(1S,3R)-3-aminocyclopentanecarboxylic acid
Conditions | Yield |
---|---|
With hydrogen; palladium 10% on activated carbon In ethyl acetate at 20℃; for 24h; | 100% |
With hydrogen; palladium 10% on activated carbon In ethyl acetate at 20℃; for 24h; | 100% |
Multi-step reaction with 3 steps 1: 79 percent / bromine / CH2Cl2 / 0.25 h / Ambient temperature 2: 87 percent / tributyltin hydride, azobisisobutyronitrile / toluene / 5 h / Heating 3: 97 percent / aq. HCl / Heating View Scheme |
methanol
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
Conditions | Yield |
---|---|
With thionyl chloride at 0 - 20℃; for 12h; | 100% |
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
Conditions | Yield |
---|---|
With thionyl chloride; 2-azabicyclo[2.2.1.]hept-5-en-3-one In methanol at 20℃; for 2h; | 100% |
With thionyl chloride In methanol at 20℃; for 2h; | 5.36 g |
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
2-Azabicyclo[2.2.1]heptan-3-one
Conditions | Yield |
---|---|
With hydrogen; palladium 10% on activated carbon In ethyl acetate at 20℃; for 24h; | 100% |
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
Conditions | Yield |
---|---|
98.2% |
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
(1R,4R,6S,7R)-6,7-dibromo-2-azabicyclo[2.2.1]heptan-3-one
Conditions | Yield |
---|---|
With bromine In dichloromethane at 0℃; for 2h; Bromination; | 98% |
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
C7H13NO2
Conditions | Yield |
---|---|
With hydrogen; palladium 10% on activated carbon In ethyl acetate at 20℃; for 24h; | 96% |
Stage #1: (1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one With hydrogen; palladium 10% on activated carbon In ethyl acetate at 20℃; for 24h; Stage #2: With hydrogenchloride In methanol; water at 20℃; for 72h; | 96% |
Multi-step reaction with 2 steps 1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 24 h / 20 °C 2: hydrogenchloride; water / 72 h / 20 °C View Scheme |
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
Conditions | Yield |
---|---|
Stage #1: (1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one With hydrogen; palladium 10% on activated carbon In ethyl acetate for 24h; Stage #2: With hydrogenchloride In methanol; water at 20℃; for 72h; | 96% |
Multi-step reaction with 2 steps 1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 24 h / 20 °C 2: hydrogenchloride / water / 72 h / 20 °C View Scheme |
methanol
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
Conditions | Yield |
---|---|
With thionyl chloride at 2 - 8℃; for 1.5h; Inert atmosphere; Industrial scale; | 95% |
With thionyl chloride at 0℃; for 2h; | |
With thionyl chloride at 0 - 13℃; for 4.25h; | |
With hydrogenchloride In water for 16h; Sealed tube; Heating; |
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
1-Bromo-2-butyne
(1S,4R)-2-But-2-ynyl-2-aza-bicyclo[2.2.1]hept-5-en-3-one
Conditions | Yield |
---|---|
With potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate | 92% |
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
allyl bromide
(1S)-2-(allyl)-2-azabicyclo[2.2.1]hept-5-en-3-one
Conditions | Yield |
---|---|
With potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate In acetonitrile for 3h; Heating; | 90% |
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
(+)-(1R,4S)-4-aminocyclopent-2-ene-1-carboxylic acid hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In water for 2h; Reflux; | 90% |
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
methyl iodide
Conditions | Yield |
---|---|
With caesium carbonate In butanone at 35℃; Inert atmosphere; | 90% |
Stage #1: (1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; for 0.5h; Stage #2: methyl iodide In tetrahydrofuran; mineral oil at 20℃; for 16h; | 75% |
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
p-methoxybenzyl chloride
(1S,4R)-2-[(4-methoxyphenyl)methyl]-2-azabicyclo[2.2.1]hept-5-en-3-one
Conditions | Yield |
---|---|
Stage #1: (1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.5h; Stage #2: p-methoxybenzyl chloride With tetra-(n-butyl)ammonium iodide In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; | 90% |
Stage #1: (1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.0833333h; Stage #2: p-methoxybenzyl chloride With tetra-(n-butyl)ammonium iodide In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 4.5h; | 21.4 g |
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
p-methoxybenzyl chloride
Conditions | Yield |
---|---|
Stage #1: (1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.5h; Stage #2: p-methoxybenzyl chloride With tetra-(n-butyl)ammonium iodide In N,N-dimethyl-formamide; mineral oil at 0℃; | 90% |
ethanol
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
(1R,4S)-ethyl 4-aminocyclopent-2-enecarboxylate hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride at 0℃; for 1h; | 89% |
With hydrogenchloride In water at 0℃; for 1h; | 73% |
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
4-methoxycarbonylphenylboronic acid
Conditions | Yield |
---|---|
With [Rh(OH)(cod)]2; (2S)-1-[(1S)-1-[bis(1,1-dimethylethyl)phosphino]ethyl]-2-(diphenylphosphino)ferrocene In tetrahydrofuran; water at 23℃; for 64h; Inert atmosphere; regioselective reaction; | 89% |
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
Conditions | Yield |
---|---|
88.8% |
tert-butyldicarbonate
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
(1R,4S)-N-(tert-Butyloxycarbonyl)-1-amino-4-(hydroxymethyl)-2-cyclopentene
Conditions | Yield |
---|---|
Stage #1: (1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one With methanesulfonic acid In tetrahydrofuran; water at 34 - 44℃; for 2.75h; Heating / reflux; Stage #2: With lithium aluminium tetrahydride In tetrahydrofuran for 18.5h; Heating / reflux; Stage #3: tert-butyldicarbonate With sodium fluoride more than 3 stages; | 88% |
2-Methylphenylboronic acid
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
Conditions | Yield |
---|---|
With [Rh(OH)(cod)]2; (2S)-1-[(1S)-1-[bis(1,1-dimethylethyl)phosphino]ethyl]-2-(diphenylphosphino)ferrocene In tetrahydrofuran; water at 23℃; for 64h; Inert atmosphere; regioselective reaction; | 87% |
benzyl bromide
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
Conditions | Yield |
---|---|
Stage #1: (1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one With sodium hydride In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 1h; Inert atmosphere; Stage #2: benzyl bromide In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil at 20℃; Inert atmosphere; | 87% |
Stage #1: (1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one With sodium hydride In tetrahydrofuran at 0℃; for 0.5h; Stage #2: benzyl bromide at 20℃; for 72h; |
di-tert-butyl dicarbonate
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
(1R,4S)-tert-butyl 3-oxo-2-azabicyclo[2.2.1]heptane-2-carboxylate
Conditions | Yield |
---|---|
Stage #1: (1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one With hydrogen; palladium 10% on activated carbon In methanol under 2585.81 Torr; for 1h; Stage #2: di-tert-butyl dicarbonate With dmap In dichloromethane at 20℃; | 86% |
Stage #1: (1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one With palladium 10% on activated carbon; hydrogen In methanol at 40℃; under 7500.75 Torr; Stage #2: di-tert-butyl dicarbonate With dmap In acetonitrile at 20℃; for 2h; | 1.94 g |
3-methoxyphenylboronic acid
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
Conditions | Yield |
---|---|
With [Rh(OH)(cod)]2; (2S)-1-[(1S)-1-[bis(1,1-dimethylethyl)phosphino]ethyl]-2-(diphenylphosphino)ferrocene In tetrahydrofuran; water at 23℃; for 64h; Inert atmosphere; regioselective reaction; | 86% |
1-bromo-4-butene
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
(1S)-2-(but-3-enyl)-2-azabicyclo[2.2.1]hept-5-en-3-one
Conditions | Yield |
---|---|
With potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate In acetonitrile for 3h; Heating; | 85% |
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
propargyl bromide
(1S,4R)-2-Prop-2-ynyl-2-aza-bicyclo[2.2.1]hept-5-en-3-one
Conditions | Yield |
---|---|
With potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate | 85% |
4-trifluoromethylphenylboronic acid
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
Conditions | Yield |
---|---|
With [Rh(OH)(cod)]2; (2S)-1-[(1S)-1-[bis(1,1-dimethylethyl)phosphino]ethyl]-2-(diphenylphosphino)ferrocene In tetrahydrofuran; water at 23℃; for 17h; Inert atmosphere; regioselective reaction; | 83% |
4-Bromophenylboronic acid
(1S,4R)-2-azabicyclo[2,2,1]hept-5-en-3-one
Conditions | Yield |
---|---|
With [Rh(OH)(cod)]2; (2S)-1-[(1S)-1-[bis(1,1-dimethylethyl)phosphino]ethyl]-2-(diphenylphosphino)ferrocene In tetrahydrofuran; water at 23℃; for 64h; Inert atmosphere; regioselective reaction; | 83% |
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