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Nanjing Yuance Industry&Trade Co., Ltd.

Purity: 99% Excellent quality with competitive price Fast delivery Appearance:white crystallline powder Storage:Store in cool dry place Package:25 kg/drum Application:Used as API Port:Shanghai, Nanjing

Irbesartan, AVAPRO, APROVEL, 138402-11-6

Cas:138402-11-6

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Zhejiang Huili Pharmaceutical Co., Ltd

ProName:Irbesartan, AVAPRO, APROVEL, 138402-11... CasNo:138402-11-6 Molecular Formula:C25H28N6O Appearance:white crystallline powder Application:Used as API DeliveryTime:Within a month PackAge:25 kg/drum Port:Shanghai, Nanjing ProductionCap

Irbesartan

Cas:138402-11-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Sinoway Industrial Co., Ltd.

We are very compeitive on irbesartan.Our mfr is GMP certified for this item with CEP document. For the treatment of hypertension, as well as diabetic nephropathy with an elevated serum creatinine and proteinuria (>300 mg/day) in patients with ty

factory supply GMP,DMF,CEP irbesartan

Cas:138402-11-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Kono Chem Co.,Ltd

Superiority kono is a leading manufacturer and supplier of chemicals in China. We develop ,produce and distribute high quality pharmaceuticals, intermediates, special chemicals and other fine chemicals. We could give you: 1.Best quality in

Anti-hypertension drugs Irbesartan CAS 138401-24-8

Cas:138402-11-6

Min.Order:1 Kilogram

FOB Price: $10.0 / 100.0

Type:Other

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Irbesartan tablets 75mg;150mg;300mg

Cas:138402-11-6

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

High quality Irbesartan 99%

Cas:138402-11-6

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Irbesartan Cas 138402-11-6 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to off-white crystalline powder Storage:-20°C Freezer Package:25kg/drum

Hot selling high quality Irbesartan Cas 138402-11-6 with reasonable price

Cas:138402-11-6

Min.Order:25 Kilogram

FOB Price: $110.0 / 120.0

Type:Trading Company

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Irbesartan

Cas:138402-11-6

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Irbesartan 138402-11-6 GMP Manufacturer

Cas:138402-11-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

Irbesartan

Cas:138402-11-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Shandong Jiulong Hisince Pharmaceutical Co.,Ltd.

High quality Irbesartan 99% with lower price: 1,In No Less ten years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service

high quality Irbesartan 99% with lower price CAS NO.138402-11-6

Cas:138402-11-6

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

Irbesartan

Cas:138402-11-6

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product s

Irbesartan

Cas:138402-11-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3-Butyl-2-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-2,4-diazaspiro[4.4]non-3-en-1-one

Cas:138402-11-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

Irbesartan

Cas:138402-11-6

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Irbesartan CAS 138402-11-6

Cas:138402-11-6

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Irbesartan Basic information Antihypertensives Telmisartan Usage and Dosage Drug interaction Overdose Adverse reactions Chemical property Application Production Method Product Name: Irbesart

Irbesartan (Lrbesartan)

Cas:138402-11-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 138402-11-6 with best quality

Cas:138402-11-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after the dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available &diam

Irbesartan cas138402-11-6

Cas:138402-11-6

Min.Order:1 Kilogram

FOB Price: $7.0 / 10.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Olmesartan medoxomil has excellent antihypertensive effect. Seven placebo-controlled clinical studies showed that olmesartan medoxomil has a potent antihypertensive effect with daily doses of 5 mg, 20 mg and 40 mg reducing the systolic blood pressu

Irbesartan

Cas:138402-11-6

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

99% Irbesartan 138402-11-6 Antihypertensive Drugs

Cas:138402-11-6

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

High Purity Irbesartan / API /cardiovascular / CAS 138402-11-6

Cas:138402-11-6

Min.Order:1 Kilogram

FOB Price: $20.0 / 40.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1,In No Less ten years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermedi

High quality Irbesartan 99% with lower price

Cas:138402-11-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Hangzhou Maytime Bio-Tech Co.,Ltd.

Name Irbesartan Appearance White crystalline powder Cas 138402-11-6 MF C25H28N6O Mol. mass 428.5294 Grade

High-purity Irbesartan,CAS:138402-11-6 China supplier with GMP

Cas:138402-11-6

Min.Order:1 Milligram

Negotiable

Type:Other

inquiry

Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:white powder/ Refer to COA Storage:Refer to COA

138402-11-6 cas 99.8% Reay stock Irbesartan

Cas:138402-11-6

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Antihypertensive drugs Irbesartan CAS:138402-11-6

Cas:138402-11-6

Min.Order:1 Kilogram

FOB Price: $287.0 / 314.3

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Irbesartan CAS:138402-11-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

Irbesartan CAS:138402-11-6

Cas:138402-11-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Terui OP New Material Technology Co., Ltd.

We have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful

138402-11-6 Irbesartan

Cas:138402-11-6

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Irbesartan

Cas:138402-11-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

3-{[2′-(1-benzyl-1H-tetrazol-5-yl)-1,1′-biphenyl-4-yl]methyl}-2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one

3-{[2′-(1-benzyl-1H-tetrazol-5-yl)-1,1′-biphenyl-4-yl]methyl}-2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

Conditions
ConditionsYield
With 5% palladium on barium sulphate; ammonium formate In water; isopropyl alcohol at 25 - 55℃; for 3.5h;100%
In water; isopropyl alcohol at 55℃; for 6h;96%
With 5% palladium on barium sulphate; ammonium formate In water; isopropyl alcohol at 55℃; for 3.5h; Time;0.091 g
trityl irbesartan
138402-10-5

trityl irbesartan

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

Conditions
ConditionsYield
Stage #1: trityl irbesartan With hydrogenchloride In water; acetone at 35 - 45℃; for 1.5 - 2h;
Stage #2: In water; acetone at 15℃; pH=11 - 13; Alkaline aqueous solution;
98.75%
With sulfuric acid In water; acetone at 35 - 40℃; for 7h;93%
With sodium hydroxide In methanol at 20℃;87%
4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-[1,1'-biphenyl]-2-carbonitrile
138401-24-8

4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-[1,1'-biphenyl]-2-carbonitrile

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

Conditions
ConditionsYield
With sodium azide; tributyltin chloride In o-xylene Heating;95%
With sodium azide; triethylamine hydrochloride In toluene at 100℃; for 24h; Solvent; Temperature; Large scale;90%
With trimethylsilylazide; tetrabutyl ammonium fluoride In water; N,N-dimethyl-formamide at 120℃; for 36h;89%
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride

2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

Conditions
ConditionsYield
Stage #1: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole; 2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride With sodium hydroxide; tetrabutylammomium bromide In water; toluene at 85℃; for 2h;
Stage #2: With hydrogenchloride; water In acetone at 20℃;
Stage #3: With potassium hydroxide In water; acetone Product distribution / selectivity;
92%
With potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In water; toluene at 90℃; for 1.5h; Heating / reflux;84.3%
Stage #1: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole; 2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride With potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In water; toluene at 90℃; for 1.5h;
Stage #2: With hydrogenchloride; water In acetone at 20℃;
Stage #3: With potassium hydroxide In water; acetone Product distribution / selectivity;
84%
Stage #1: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole; 2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride With tetrabutylammomium bromide; potassium carbonate In ethyl acetate at 25 - 80℃; for 10h;
Stage #2: With hydrogenchloride In methanol at 0 - 30℃; for 3.5h;
Stage #3: With sodium hydroxide In water; toluene at 0 - 30℃; for 0.5h; pH=12;
trityl irbesartan
138402-10-5

trityl irbesartan

A

methoxytriphenylmethane
596-31-6

methoxytriphenylmethane

B

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

Conditions
ConditionsYield
Stage #1: trityl irbesartan With hydroxylamine hydrochloride In methanol; water; acetone at 20℃; for 2h;
Stage #2: With sodium hydroxide In methanol; water; acetone at 20 - 25℃; pH=3.8 - 12.5;
A n/a
B 91%
Stage #1: trityl irbesartan With hydroxylamine hydrochloride In methanol; water; isopropyl alcohol; acetone at 20℃; for 2h;
Stage #2: With sodium hydroxide In methanol; water; acetone at 20 - 25℃; pH=12.0 - 12.5;
A n/a
B 89%
1-pentanoylamino-cyclopentanecarboxylic acid (2'-cyano-biphenyl-4-ylmethyl)-amide
141745-71-3

1-pentanoylamino-cyclopentanecarboxylic acid (2'-cyano-biphenyl-4-ylmethyl)-amide

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

Conditions
ConditionsYield
Stage #1: 1-pentanoylamino-cyclopentanecarboxylic acid (2'-cyano-biphenyl-4-ylmethyl)-amide With sodium azide; tributyltin chloride; N,N-dimethyl-formamide In o-xylene at 15 - 155℃; for 1h;
Stage #2: With hydrogenchloride In dichloromethane; o-xylene; water at 20℃; for 1h; Product distribution / selectivity;
90%
With sodium azide; tributyltin chloride; N,N-dimethyl-formamide In o-xylene at 150 - 155℃; for 20h;71%
Multi-step reaction with 2 steps
1: 81 percent / trifluoro acetic acid / toluene / Heating
2: 95 percent / tributyl tin chloride; sodium azide / o-xylene / Heating
View Scheme
4-[(α-N-pentanoylamino)cyclopentamidomethyl]-2'-carboxamidobiphenyl
945540-18-1

4-[(α-N-pentanoylamino)cyclopentamidomethyl]-2'-carboxamidobiphenyl

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

Conditions
ConditionsYield
Stage #1: 4-[(α-N-pentanoylamino)cyclopentamidomethyl]-2'-carboxamidobiphenyl With sodium azide; tributyltin chloride; N,N-dimethyl-formamide In o-xylene at 15 - 155℃; for 1h;
Stage #2: With hydrogenchloride In dichloromethane; o-xylene; water at 20 - 25℃; for 1.5h; Product distribution / selectivity;
88.5%
With sodium azide; tributyltin chloride; N,N-dimethyl-formamide for 50h;65%
Multi-step reaction with 2 steps
1: 65 percent / trifluoroacetic acid / o-xylene / 17 h / Heating
2: 80 percent / sodium azide; tributyltin chloride; DMF / o-xylene / 40 h / 150 - 155 °C
View Scheme
Multi-step reaction with 2 steps
1.1: trifluoroacetic acid / o-xylene / 15 h / 25 - 140 °C
1.2: 0.17 h / 25 - 30 °C / pH 9
2.1: sodium azide; tributyltin chloride / o-xylene / 25 °C / Heating / reflux
2.2: 2.25 h / 20 - 25 °C
2.3: 2 h / 20 - 25 °C / pH 4.5 - 4.8
View Scheme
Multi-step reaction with 3 steps
1.1: trifluoroacetic acid / o-xylene / 15 h / 25 - 140 °C
1.2: 0.17 h / 25 - 30 °C / pH 9
2.1: pyridine; p-toluenesulfonyl chloride / 1 h / 70 - 75 °C
3.1: sodium azide; tributyltin chloride / o-xylene / 60 h / 25 - 137 °C
3.2: 1 h / 10 - 15 °C / pH 11.5 - 12
3.3: 10 - 30 °C / pH 4.6 - 4.8
View Scheme
3-[4-bromobenzyl]-2-n-butyl-1,3-diazaspiro[4.4]non-1-en-4-one
731851-41-5

3-[4-bromobenzyl]-2-n-butyl-1,3-diazaspiro[4.4]non-1-en-4-one

2-(N-triphenylmethyl-tetrazol-5-yl)-phenylboronic acid
144873-97-2

2-(N-triphenylmethyl-tetrazol-5-yl)-phenylboronic acid

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

Conditions
ConditionsYield
With potassium hydroxide; tetrakis(triphenylphosphine) palladium(0) In methanol for 10h; Suzuki coupling; Heating;84%
Stage #1: 3-[4-bromobenzyl]-2-n-butyl-1,3-diazaspiro[4.4]non-1-en-4-one; 2-(N-triphenylmethyl-tetrazol-5-yl)-phenylboronic acid With potassium carbonate; tetrakis(triphenylphosphine) palladium(0) In water; toluene at 25 - 85℃; for 0.5h;
Stage #2: With hydrogenchloride In water; 4-methyl-2-pentanone Product distribution / selectivity;
22%
3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-2-thiophen-2-yl-1,3-diaza-spiro[4.4]non-1-en-4-one
1199814-92-0

3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-2-thiophen-2-yl-1,3-diaza-spiro[4.4]non-1-en-4-one

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

Conditions
ConditionsYield
With hydrogen; Raney nickel In methanol at 20℃;84%
1-[(2'-carboxamidobiphenyl-4-yl)methyl]-2-n-butyl-4-spirocyclopentane-2-imidazolin-5-one
144625-34-3

1-[(2'-carboxamidobiphenyl-4-yl)methyl]-2-n-butyl-4-spirocyclopentane-2-imidazolin-5-one

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

Conditions
ConditionsYield
With sodium azide; tributyltin chloride; N,N-dimethyl-formamide In o-xylene at 150 - 155℃; for 40h;80%
Stage #1: 1-[(2'-carboxamidobiphenyl-4-yl)methyl]-2-n-butyl-4-spirocyclopentane-2-imidazolin-5-one With sodium azide; tributyltin chloride In o-xylene at 25℃; Heating / reflux;
Stage #2: With hydrogenchloride In dichloromethane; o-xylene; water at 20 - 25℃; for 2.25h;
Stage #3: With ammonia In dichloromethane; o-xylene; water at 20 - 25℃; for 2h; pH=4.5 - 4.8; Product distribution / selectivity;
77%
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride

2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

Conditions
ConditionsYield
Stage #1: 2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride With potassium carbonate; tetrabutylammomium bromide In water at 25 - 60℃;
Stage #2: 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile In water at 55 - 60℃;
Stage #3: With sodium azide; triethylamine hydrochloride In toluene at 25 - 105℃; Product distribution / selectivity;
79%
methanol
67-56-1

methanol

trityl irbesartan
138402-10-5

trityl irbesartan

A

methoxytriphenylmethane
596-31-6

methoxytriphenylmethane

B

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

Conditions
ConditionsYield
for 10h; Heating / reflux;A 73%
B 71%
N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]amine hydrochloride

N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]amine hydrochloride

2-butyl-3-oxa-1-aza-spiro[4.4]non-1-en-4-one
15026-81-0

2-butyl-3-oxa-1-aza-spiro[4.4]non-1-en-4-one

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

Conditions
ConditionsYield
With methanesulfonic acid In 1-methyl-pyrrolidin-2-one at 160℃; under 150.015 Torr; for 2.5h; Product distribution / selectivity;70.5%
In 1-methyl-pyrrolidin-2-one at 140℃; under 150.015 Torr; for 5h; Product distribution / selectivity;60.4%
2-n-butyl-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one hydrobromide
329055-24-5

2-n-butyl-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one hydrobromide

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

Conditions
ConditionsYield
In ethanol; dichloromethane; water Product distribution / selectivity; Heating / reflux;
2-butyl-3-{2'-[2-(1-methyl-1-phenyl-ethyl)-2H-tetrazol-5-yl]-biphenyl-4-ylmethyl}-1,3-diaza-spiro[4.4]non-1-en-4-one
852357-70-1

2-butyl-3-{2'-[2-(1-methyl-1-phenyl-ethyl)-2H-tetrazol-5-yl]-biphenyl-4-ylmethyl}-1,3-diaza-spiro[4.4]non-1-en-4-one

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

Conditions
ConditionsYield
Stage #1: 2-butyl-3-{2'-[2-(1-methyl-1-phenyl-ethyl)-2H-tetrazol-5-yl]-biphenyl-4-ylmethyl}-1,3-diaza-spiro[4.4]non-1-en-4-one With hydrogenchloride; water In toluene at 15 - 20℃; for 4h;
Stage #2: With sodium acetate In water
1-cyano-1-n-pentanoylaminocyclopentane
194984-24-2

1-cyano-1-n-pentanoylaminocyclopentane

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 654 g / aq. hydrochloric acid / 2 h / 55 - 60 °C
2: 93 percent / dicyclohexylcarbodiimide; 1-hydroxybenzotriazole; diisopropylethylamine / CH2Cl2 / 7 h / 38 - 41 °C
3: 71 percent / sodium azide; tributyltin chloride; N,N-dimethylformamide / o-xylene / 20 h / 150 - 155 °C
View Scheme
N-pentanoylaminocyclopentane-1-carboxylic acid
15026-80-9

N-pentanoylaminocyclopentane-1-carboxylic acid

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 93 percent / dicyclohexylcarbodiimide; 1-hydroxybenzotriazole; diisopropylethylamine / CH2Cl2 / 7 h / 38 - 41 °C
2: 71 percent / sodium azide; tributyltin chloride; N,N-dimethylformamide / o-xylene / 20 h / 150 - 155 °C
View Scheme
Multi-step reaction with 3 steps
1: 90 percent / dicyclohexylcarbodiimide; N-hydroxybenzotriazole; diisopropylethylamine / CH2Cl2 / 4.5 h / Heating
2: 65 percent / trifluoroacetic acid / o-xylene / 17 h / Heating
3: 80 percent / sodium azide; tributyltin chloride; DMF / o-xylene / 40 h / 150 - 155 °C
View Scheme
Multi-step reaction with 2 steps
1: 90 percent / dicyclohexylcarbodiimide; N-hydroxybenzotriazole; diisopropylethylamine / CH2Cl2 / 4.5 h / Heating
2: 65 percent / sodium azide; tributyltin chloride; DMF / 50 h
View Scheme
n-valeryl chloride
638-29-9

n-valeryl chloride

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: triethylamine / CH2Cl2 / 2.67 h / 0 - 5 °C
2: 654 g / aq. hydrochloric acid / 2 h / 55 - 60 °C
3: 93 percent / dicyclohexylcarbodiimide; 1-hydroxybenzotriazole; diisopropylethylamine / CH2Cl2 / 7 h / 38 - 41 °C
4: 71 percent / sodium azide; tributyltin chloride; N,N-dimethylformamide / o-xylene / 20 h / 150 - 155 °C
View Scheme
Multi-step reaction with 4 steps
1: 82 percent / sodium hydroxide / H2O; toluene / 2 h / 0 - 10 °C
2: 96 percent / 1-hydroxybenzotriazole; dicyclohexyl carbodiimide / CH2Cl2 / 25 - 35 °C
3: 81 percent / trifluoro acetic acid / toluene / Heating
4: 95 percent / tributyl tin chloride; sodium azide / o-xylene / Heating
View Scheme
1-aminocyclopentanecarbonitrile hydrochloride

1-aminocyclopentanecarbonitrile hydrochloride

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: triethylamine / CH2Cl2 / 2.67 h / 0 - 5 °C
2: 654 g / aq. hydrochloric acid / 2 h / 55 - 60 °C
3: 93 percent / dicyclohexylcarbodiimide; 1-hydroxybenzotriazole; diisopropylethylamine / CH2Cl2 / 7 h / 38 - 41 °C
4: 71 percent / sodium azide; tributyltin chloride; N,N-dimethylformamide / o-xylene / 20 h / 150 - 155 °C
View Scheme
2-(4-aminomethylphenyl)benzamide hydrochloride

2-(4-aminomethylphenyl)benzamide hydrochloride

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 90 percent / dicyclohexylcarbodiimide; N-hydroxybenzotriazole; diisopropylethylamine / CH2Cl2 / 4.5 h / Heating
2: 65 percent / trifluoroacetic acid / o-xylene / 17 h / Heating
3: 80 percent / sodium azide; tributyltin chloride; DMF / o-xylene / 40 h / 150 - 155 °C
View Scheme
Multi-step reaction with 2 steps
1: 90 percent / dicyclohexylcarbodiimide; N-hydroxybenzotriazole; diisopropylethylamine / CH2Cl2 / 4.5 h / Heating
2: 65 percent / sodium azide; tributyltin chloride; DMF / 50 h
View Scheme
Multi-step reaction with 2 steps
1.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide / dichloromethane / 6 h / 25 - 33 °C
2.1: sodium azide; tributyltin chloride; N,N-dimethyl-formamide / o-xylene / 1 h / 15 - 155 °C
2.2: 1.5 h / 20 - 25 °C
View Scheme
Multi-step reaction with 3 steps
1.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide / dichloromethane / 6 h / 25 - 33 °C
2.1: trifluoroacetic acid / o-xylene / 15 h / 25 - 140 °C
2.2: 0.17 h / 25 - 30 °C / pH 9
3.1: sodium azide; tributyltin chloride / o-xylene / 25 °C / Heating / reflux
3.2: 2.25 h / 20 - 25 °C
3.3: 2 h / 20 - 25 °C / pH 4.5 - 4.8
View Scheme
Multi-step reaction with 4 steps
1.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide / dichloromethane / 6 h / 25 - 33 °C
2.1: trifluoroacetic acid / o-xylene / 15 h / 25 - 140 °C
2.2: 0.17 h / 25 - 30 °C / pH 9
3.1: pyridine; p-toluenesulfonyl chloride / 1 h / 70 - 75 °C
4.1: sodium azide; tributyltin chloride / o-xylene / 60 h / 25 - 137 °C
4.2: 1 h / 10 - 15 °C / pH 11.5 - 12
4.3: 10 - 30 °C / pH 4.6 - 4.8
View Scheme
[(2'-cyanobiphenyl-4-yl)methyl]amine
133690-92-3

[(2'-cyanobiphenyl-4-yl)methyl]amine

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 96 percent / 1-hydroxybenzotriazole; dicyclohexyl carbodiimide / CH2Cl2 / 25 - 35 °C
2: 81 percent / trifluoro acetic acid / toluene / Heating
3: 95 percent / tributyl tin chloride; sodium azide / o-xylene / Heating
View Scheme
Multi-step reaction with 2 steps
1.1: triphenyl phosphate / pyridine / 0.17 h / 150 °C / microwave irradiation
1.2: 75 percent / pyridine / 0.17 h / 250 °C / 7500.6 Torr / microwave irradiation
2.1: 73 percent / tri-n-butyltin chloride; sodium azide; tetrabutylammonium bromide / dimethylformamide / 1 h / 220 °C / 6000.48 Torr / microwave irradiation
View Scheme
Multi-step reaction with 3 steps
1.1: potassium hydroxide; tert-butyl alcohol / 70 - 75 °C
1.2: 1 h / 2 - 5 °C / pH 1.2 - 1.4
2.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide / dichloromethane / 6 h / 25 - 33 °C
3.1: sodium azide; tributyltin chloride; N,N-dimethyl-formamide / o-xylene / 1 h / 15 - 155 °C
3.2: 1.5 h / 20 - 25 °C
View Scheme
Multi-step reaction with 4 steps
1.1: potassium hydroxide; tert-butyl alcohol / 70 - 75 °C
1.2: 1 h / 2 - 5 °C / pH 1.2 - 1.4
2.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide / dichloromethane / 6 h / 25 - 33 °C
3.1: trifluoroacetic acid / o-xylene / 15 h / 25 - 140 °C
3.2: 0.17 h / 25 - 30 °C / pH 9
4.1: sodium azide; tributyltin chloride / o-xylene / 25 °C / Heating / reflux
4.2: 2.25 h / 20 - 25 °C
4.3: 2 h / 20 - 25 °C / pH 4.5 - 4.8
View Scheme
Multi-step reaction with 5 steps
1.1: potassium hydroxide; tert-butyl alcohol / 70 - 75 °C
1.2: 1 h / 2 - 5 °C / pH 1.2 - 1.4
2.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide / dichloromethane / 6 h / 25 - 33 °C
3.1: trifluoroacetic acid / o-xylene / 15 h / 25 - 140 °C
3.2: 0.17 h / 25 - 30 °C / pH 9
4.1: pyridine; p-toluenesulfonyl chloride / 1 h / 70 - 75 °C
5.1: sodium azide; tributyltin chloride / o-xylene / 60 h / 25 - 137 °C
5.2: 1 h / 10 - 15 °C / pH 11.5 - 12
5.3: 10 - 30 °C / pH 4.6 - 4.8
View Scheme
1-amino-1-cyclopentanecarboxylic acid
52-52-8

1-amino-1-cyclopentanecarboxylic acid

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 82 percent / sodium hydroxide / H2O; toluene / 2 h / 0 - 10 °C
2: 96 percent / 1-hydroxybenzotriazole; dicyclohexyl carbodiimide / CH2Cl2 / 25 - 35 °C
3: 81 percent / trifluoro acetic acid / toluene / Heating
4: 95 percent / tributyl tin chloride; sodium azide / o-xylene / Heating
View Scheme
(2'-cyano-biphenyl-4-ylmethyl)-carbamic acid tert-butyl ester

(2'-cyano-biphenyl-4-ylmethyl)-carbamic acid tert-butyl ester

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 71 percent / triphenyl phosphate / pyridine / 0.17 h / 250 °C / 11250.9 Torr
2: 73 percent / tri-n-butyltin chloride; sodium azide; tetrabutylammonium bromide / dimethylformamide / 1 h / 220 °C / 6000.48 Torr / microwave irradiation
View Scheme
cycloleucine methyl ester hydrochloride
60421-23-0

cycloleucine methyl ester hydrochloride

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 71 percent / triphenyl phosphate / pyridine / 0.17 h / 250 °C / 11250.9 Torr
2: 73 percent / tri-n-butyltin chloride; sodium azide; tetrabutylammonium bromide / dimethylformamide / 1 h / 220 °C / 6000.48 Torr / microwave irradiation
View Scheme
Multi-step reaction with 2 steps
1.1: triphenyl phosphate / pyridine / 0.17 h / 150 °C / microwave irradiation
1.2: 75 percent / pyridine / 0.17 h / 250 °C / 7500.6 Torr / microwave irradiation
2.1: 73 percent / tri-n-butyltin chloride; sodium azide; tetrabutylammonium bromide / dimethylformamide / 1 h / 220 °C / 6000.48 Torr / microwave irradiation
View Scheme
valeric acid
109-52-4

valeric acid

Phenylmagnesium halide

Phenylmagnesium halide

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triphenyl phosphate / pyridine / 0.17 h / 150 °C / microwave irradiation
1.2: 75 percent / pyridine / 0.17 h / 250 °C / 7500.6 Torr / microwave irradiation
2.1: 73 percent / tri-n-butyltin chloride; sodium azide; tetrabutylammonium bromide / dimethylformamide / 1 h / 220 °C / 6000.48 Torr / microwave irradiation
View Scheme
1-bromomethyl-4-bromobenzene
589-15-1

1-bromomethyl-4-bromobenzene

4-bromo-2.2.3.3-tetramethyl-bicyclo-<0.1.2>-pentanol-(1)-one-(5)

4-bromo-2.2.3.3-tetramethyl-bicyclo-<0.1.2>-pentanol-(1)-one-(5)

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 94.6 percent / K2CO3 / dimethylformamide / 8 h / 25 - 35 °C
2: 84 percent / potassium hydroxide; Pd(PPh3)4 / methanol / 10 h / Heating
View Scheme
2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride

2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 94.6 percent / K2CO3 / dimethylformamide / 8 h / 25 - 35 °C
2: 84 percent / potassium hydroxide; Pd(PPh3)4 / methanol / 10 h / Heating
View Scheme
ethyl 1-aminocyclopentanecarboxylate
1664-35-3

ethyl 1-aminocyclopentanecarboxylate

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 96 percent / AcOH / xylene / 6.5 h / Heating
2: 1.) NaH / 1.) DMF, RT, 0.5 h, 2.) DMF, RT, 1 h
3: 68 percent / Bu3SnN3 / xylene / 88 h / Heating
View Scheme
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
114772-54-2

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) NaH / 1.) DMF, RT, 0.5 h, 2.) DMF, RT, 1 h
2: 68 percent / Bu3SnN3 / xylene / 88 h / Heating
View Scheme
potassium hydroxide
1310-58-3

potassium hydroxide

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

irbesartan potassium

irbesartan potassium

Conditions
ConditionsYield
In ipa at 50℃; for 1.58333h; Heating / reflux;89%
In ipa at 50℃; for 1.5h; Heating / reflux;51.4%
copper(II) choride dihydrate

copper(II) choride dihydrate

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

[Cu(irbesartan)2(H2O)]

[Cu(irbesartan)2(H2O)]

Conditions
ConditionsYield
With sodium hydroxide In ethanol pH=6;85%
sodium hydroxide
1310-73-2

sodium hydroxide

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

irbesartan sodium

irbesartan sodium

Conditions
ConditionsYield
In ipa at 60℃; for 2.5h; Heating / reflux;66%
In water Product distribution / selectivity;
(3R,4S,5S,6S)-2-bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate
57820-69-6

(3R,4S,5S,6S)-2-bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

A

(2S,3S,4S,5R,6R)-3,4,5-Triacetoxy-6-{5-[4'-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-ylmethyl)-biphenyl-2-yl]-tetrazol-1-yl}-tetrahydro-pyran-2-carboxylic acid methyl ester

(2S,3S,4S,5R,6R)-3,4,5-Triacetoxy-6-{5-[4'-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-ylmethyl)-biphenyl-2-yl]-tetrazol-1-yl}-tetrahydro-pyran-2-carboxylic acid methyl ester

B

(2S,3S,4S,5R,6R)-3,4,5-Triacetoxy-6-{5-[4'-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-ylmethyl)-biphenyl-2-yl]-tetrazol-2-yl}-tetrahydro-pyran-2-carboxylic acid methyl ester

(2S,3S,4S,5R,6R)-3,4,5-Triacetoxy-6-{5-[4'-(2-butyl-4-oxo-1,3-diaza-spiro[4.4]non-1-en-3-ylmethyl)-biphenyl-2-yl]-tetrazol-2-yl}-tetrahydro-pyran-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With silver carbonate In toluene at 100℃; for 18h; protection from light;A 30%
B 59%
methanol
67-56-1

methanol

water
7732-18-5

water

silver nitrate

silver nitrate

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

[Ag2(2-butyl-3-[p-(o-(1H-tetrazol-5-yl)phenyl)benzyl]-1,3-diazospiro[4.4]non-1-en-4-one(-H))2]*methanol*0.17water

[Ag2(2-butyl-3-[p-(o-(1H-tetrazol-5-yl)phenyl)benzyl]-1,3-diazospiro[4.4]non-1-en-4-one(-H))2]*methanol*0.17water

Conditions
ConditionsYield
In methanol; water; acetonitrile mixing CH3CN soln. of silver compd., water and methanolic soln. of tetrazole deriv., keeping at room temp. in dark with slow evapn.; isolation of crystals, elem. anal.;56%
2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

methyl iodide
74-88-4

methyl iodide

A

2-n-butyl-3-<<2'-(2-methyltetrazol-5-yl)biphenyl-4-yl>methyl>-1,3-diazaspiro<4.4>non-1-en-4-one

2-n-butyl-3-<<2'-(2-methyltetrazol-5-yl)biphenyl-4-yl>methyl>-1,3-diazaspiro<4.4>non-1-en-4-one

B

2-n-butyl-3-<<2'-(1-methyltetrazol-5-yl)biphenyl-4-yl>methyl>-1,3-diazaspiro<4.4>non-1-en-4-one

2-n-butyl-3-<<2'-(1-methyltetrazol-5-yl)biphenyl-4-yl>methyl>-1,3-diazaspiro<4.4>non-1-en-4-one

Conditions
ConditionsYield
With sodium hydride 1.) DMF, RT, 0.5 h, 2.) DMF, RT, 4 h; Yield given. Multistep reaction. Yields of byproduct given;
2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

2-(tetrazol-5-yl)-4'-methyl-1,1'-biphenyl
120568-11-8

2-(tetrazol-5-yl)-4'-methyl-1,1'-biphenyl

Conditions
ConditionsYield
In phosphate buffer at 37℃; pH=7.40; Kinetics; Further Variations:; Solvents; Temperatures; pH-values;
2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

4-{4-oxo-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1,3-diaza-spiro[4.4]non-1-en-2-yl}-butyric acid

4-{4-oxo-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1,3-diaza-spiro[4.4]non-1-en-2-yl}-butyric acid

Conditions
ConditionsYield
With potassium iodate; potassium iodide In water; dimethyl sulfoxide at 30℃; Kinetics; Further Variations:; Temperatures; concentrations of reagents;

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