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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Methyl trans-2-hexenoate supplier in China

Cas:13894-63-8

Min.Order:1 Kilogram

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Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

2-Hexenoic acid, methylester, (2E)-

Cas:13894-63-8

Min.Order:1 Kilogram

FOB Price: $6.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Now we would like to update our product list for you, kindly check the below information: 1. Catalyst series ( such as Noble Metal Catalyst, Phosphorous ligand, etc ) 2. Pharmaceutical Intermediate ( such as diabtes series, Anti

13894-63-8

Cas:13894-63-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

METHYL TRANS-2-HEXENOATE, 98

Cas:13894-63-8

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2-Hexenoic acid, methylester, (2E)-

Cas:13894-63-8

Min.Order:0

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Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-Hexenoic acid, methylester, (2E)-

Cas:13894-63-8

Min.Order:0

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Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providing h

Factory Supply Methyl trans-2-hexenoate

Cas:13894-63-8

Min.Order:0

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Type:Other

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GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

Methyl trans-2-hexenoate

Cas:13894-63-8

Min.Order:0

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Type:Lab/Research institutions

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Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

Methyl trans-2-hexenoate

Cas:13894-63-8

Min.Order:0

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Type:Manufacturers

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Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

METHYL TRANS-2-HEXENOATE, 98

Cas:13894-63-8

Min.Order:0

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Type:Lab/Research institutions

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Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

Methyl trans-2-hexenoate

Cas:13894-63-8

Min.Order:0

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Antimex Chemical Limied

CSR081605-64857 Application:reagent

CSR081605-64857

Cas:13894-63-8

Min.Order:0

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BOC Sciences

We are committed to providing our customers with the best products and services at the most competitive prices.Appearance:white crystalline powder Storage:Room temperature with sealed well Package:according to the clients requirement Application:Use

METHYL TRANS-2-HEXENOATE, 98

Cas:13894-63-8

Min.Order:0

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Type:Trading Company

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Hangzhou Fandachem Co.,Ltd

2-Hexenoic acid, methylester, (2E)- cas 13894-63-8Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

2-Hexenoic acid, methylester, (2E)- cas 13894-63-8

Cas:13894-63-8

Min.Order:0

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Type:Other

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Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

METHYL TRANS-2-HEXENOATE, 98

Cas:13894-63-8

Min.Order:0

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Type:Lab/Research institutions

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers2. Produce products of different specifications and sizes according to your requirements.3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures sta

METHYL TRANS-2-HEXENOATE, 98

Cas:13894-63-8

Min.Order:0

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Type:Lab/Research institutions

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Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

13894-63-8

Cas:13894-63-8

Min.Order:0

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Shanghai Yuanye Bio-Technology Co., Ltd.

Known for its best quality and competitve price, this chemicals we offered is widely appreciated by our customers.Appearance:White powder Storage:keep sealed and keep from direct light Package:According client's requirements Application:pharmaceutica

Methyl Trans-2-Hexenoate manufacturer

Cas:13894-63-8

Min.Order:0

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Type:Trading Company

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ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

METHYL TRANS-2-HEXENOATE, 98

Cas:13894-63-8

Min.Order:0

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LEAP CHEM Co., Ltd.

Best Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP

methyl (2E)-hex-2-enoate

Cas:13894-63-8

Min.Order:0

Negotiable

Type:Trading Company

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Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

Methyl trans-2-hexenoate

Cas:13894-63-8

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

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HENAN SUNLAKE ENTERPRISE CORPORATION

Henan Sunlake Enterprise Corporation Our Advantages 1, Any inquiry about ch

METHYL TRANS-2-HEXENOATE, 98

Cas:13894-63-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Watson International Ltd

Watson International Ltd' has a very strong R&D and technical capacity supported by FCAD's platform. The subsidiaries under FCAD Group have accumulated much know-how of different fine chemical branches. For example, Apnoke Scientific L

Methyl trans-2-hexenoate

Cas:13894-63-8

Min.Order:1 Gram

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Type:Lab/Research institutions

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Hebei MuHai biological technology co., LTD

Deliver Day : within 24 hours after get the payment Payment Terms : T/T, Western Union, MoneyGram, bank transfer Packaging: Safe and discreet packaging Shipment : UPS / DHL / FEDEX / EMS and Client's request Origin China Quality : High

2-Hexenoic acid, methylester, (2E)-CAS NO.: 13894-63-8

Cas:13894-63-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Trading Company

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Xiamen BaiFuchem Co.,Ltd

BaiFuChem is a Professional chemical raw material supplier in China, our main products include Biochemical , Pharma Intermediate and Organic chemical etc. BaiFuChem have wealth of products,experience , expertise and state-of-the-art

Hot Sale Methyl trans-2-hexenoate

Cas:13894-63-8

Min.Order:1 Kilogram

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Type:Other

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SuZhou LaiTeou

Chinese name: trans - 2 - hexene acid methyl ester English synonyms: (E) - 2 - caproic acid methyl ester; Trans - 2 - hexene acid methyl ester; Trans - methyl 2 - hexene; Methyl - 2 - hexene; Trans - 2 - methyl hexene, 98%; The methyl - 2 - hexen

2-Hexenoic acid, methylester, (2E)-

Cas:13894-63-8

Min.Order:1 Kilogram

FOB Price: $100.0

Type:Trading Company

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Shijiazhuang Yesheng Chemical Technology Co., Ltd

ProName: High quality Methyl trans-2-hexenoate ... CasNo: 13894-63-8 Molecular Formula: C7H12O2 Appearance: white-off powder or granule ( referto ... Application: Pharma intermediate DeliveryTime: IN STOCK PackAge: 25kgs/fiber drum Port: SH

METHYL TRANS-2-HEXENOATE, 98

Cas:13894-63-8

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou Share Chemical Co., Ltd

At Share Chemical Company, we scrupulously abide by our policy of “Excellent Quality at a Reasonable Price”. We strive to satisfy all of our customers by providing the finest quality products supported by the finest in customer servi

Methyl trans-2-hexenoate

Cas:13894-63-8

Min.Order:1 Gram

Negotiable

Type:Other

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AOPHARM

Aopharm is specialized in APIs, pharmaceutical intermediates & fine chemicals. 1. The best quality, competitive price. 2. The best service before or after shipment. 3. Rich experience in export operation. 4. Rich experience in modes of tran

METHYL TRANS-2-HEXENOATE, 98

Cas:13894-63-8

Min.Order:0 Metric Ton

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Type:Trading Company

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Shandong Bolode Bio-Technology Co., LTD

1.High quality 2.Competitive price 3.Best service 4.Professional manufacturer Appearance: liquid Package: according to custom's requirement Transportation:by express ,sea or air Port:China port

2-Hexenoic acid, methylester, (2E)-

Cas:13894-63-8

Min.Order:0 Metric Ton

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Type:Trading Company

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Synthetic route

methanol
67-56-1

methanol

(E)-2-Hexenoic acid
13419-69-7

(E)-2-Hexenoic acid

methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

Conditions
ConditionsYield
Stage #1: (E)-2-Hexenoic acid With oxalyl dichloride In tetrahydrofuran; N,N-dimethyl-formamide for 0.5h; Cooling with ice;
Stage #2: methanol In tetrahydrofuran; N,N-dimethyl-formamide at 10 - 35℃; for 2h;
100%
With ethenetetracarbonitrile at 60℃; for 48h;43%
With sulfuric acid Ambient temperature;
With sulfuric acid Reflux;
(2E,4E)-methylhexa-2,4-dienoate
689-89-4

(2E,4E)-methylhexa-2,4-dienoate

methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

Conditions
ConditionsYield
With hydrogen; montmorillonit-bipyridinpalladium(II)-acetate In tetrahydrofuran Ambient temperature;97%
(E)-2-Hexenoic acid
13419-69-7

(E)-2-Hexenoic acid

methyl iodide
74-88-4

methyl iodide

methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

Conditions
ConditionsYield
With cesium fluoride In N,N-dimethyl-formamide at 10 - 15℃; for 24h;80%
3-Benzenesulfonyl-hexanoic acid methyl ester
93101-95-2

3-Benzenesulfonyl-hexanoic acid methyl ester

methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane76%
methyl (triphenylphosphoranylidene)acetate
21204-67-1

methyl (triphenylphosphoranylidene)acetate

butan-1-ol
71-36-3

butan-1-ol

A

methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

B

methyl (Z)-hex-2-enoate
13894-64-9

methyl (Z)-hex-2-enoate

Conditions
ConditionsYield
Stage #1: butan-1-ol With Celite; pyridinium chlorochromate In dichloromethane at 20℃;
Stage #2: methyl (triphenylphosphoranylidene)acetate In dichloromethane at 20℃; for 24h; Wittig olefination;
A 73%
B n/a
butyraldehyde
123-72-8

butyraldehyde

methyl (triphenylphosphoranylidene)acetate
21204-67-1

methyl (triphenylphosphoranylidene)acetate

methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

Conditions
ConditionsYield
In tetrahydrofuran for 4h; Reflux;70%
butyraldehyde
123-72-8

butyraldehyde

methyl (triphenylphosphoranylidene)acetate
21204-67-1

methyl (triphenylphosphoranylidene)acetate

A

methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

B

methyl (Z)-hex-2-enoate
13894-64-9

methyl (Z)-hex-2-enoate

Conditions
ConditionsYield
for 3h; Heating;A 51%
B n/a
In hexane at 25℃; for 42h; Yield given. Yields of byproduct given;
With silica gel In hexane at 25℃; for 2h; Yield given. Yields of byproduct given;
(E)-2-Hexenoic acid
13419-69-7

(E)-2-Hexenoic acid

methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

methanol
67-56-1

methanol

2-hydroxy-3-heptenenitrile
148811-03-4

2-hydroxy-3-heptenenitrile

methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

Conditions
ConditionsYield
With tert.-butylhydroperoxide; triethylamine; tris(triphenylphosphine)ruthenium(II) chloride 1.) benzene, 15 to 20 deg C, 8 h; Yield given. Multistep reaction;
With tert.-butylhydroperoxide; triethylamine; tris(triphenylphosphine)ruthenium(II) chloride 1) CH2Cl2, benzene, r.t., overnight, 2) 3 h; Yield given. Multistep reaction;
methyl (trimethylsilyl)acetate
2916-76-9

methyl (trimethylsilyl)acetate

butyraldehyde
123-72-8

butyraldehyde

A

methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

B

methyl (Z)-hex-2-enoate
13894-64-9

methyl (Z)-hex-2-enoate

Conditions
ConditionsYield
With lithium diisopropyl amide In tetrahydrofuran
Methyl diethylphosphonoacetate
1067-74-9

Methyl diethylphosphonoacetate

butyraldehyde
123-72-8

butyraldehyde

methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

Conditions
ConditionsYield
With sodium hydride In diethylene glycol dimethyl ether
Stage #1: Methyl diethylphosphonoacetate With sodium hydride In 1,2-dimethoxyethane at 0℃; for 0.5h; Inert atmosphere;
Stage #2: butyraldehyde In 1,2-dimethoxyethane at 0 - 20℃; for 3h; Inert atmosphere;
trimethyl phosphonoacetate
5927-18-4

trimethyl phosphonoacetate

butyraldehyde
123-72-8

butyraldehyde

A

methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

B

methyl (Z)-hex-2-enoate
13894-64-9

methyl (Z)-hex-2-enoate

Conditions
ConditionsYield
With sodium methylate In N,N-dimethyl-formamide for 6h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
hex-2t(?)-enoic acid

hex-2t(?)-enoic acid

methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

Conditions
ConditionsYield
With diethyl ether
(E)-4-Benzenesulfonyl-2-diethylamino-hept-2-enenitrile
344890-71-7

(E)-4-Benzenesulfonyl-2-diethylamino-hept-2-enenitrile

methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 76 percent / HCl (3N) / 20 °C
2: 76 percent / DBU / CH2Cl2
View Scheme
(E)-2-Hexenal
6728-26-3

(E)-2-Hexenal

methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ZnI2, 2N HCl
2: 1.) t-BuOOH 2.) Et3N / 1.) RuCl2(PPh3)3 / 1.) benzene, 15 to 20 deg C, 8 h
View Scheme
oxalyl dichloride
79-37-8

oxalyl dichloride

(E)-2-Hexenoic acid
13419-69-7

(E)-2-Hexenoic acid

sodium hydrogencarbonate
144-55-8

sodium hydrogencarbonate

methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

Conditions
ConditionsYield
In tetrahydrofuran; methanol; N,N-dimethyl-formamide
trimethyl phosphonoacetate
5927-18-4

trimethyl phosphonoacetate

butyraldehyde
123-72-8

butyraldehyde

methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

Conditions
ConditionsYield
Horner-Wadsworth-Emmons Olefination;
methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

o-lithiomethylphenyl isocyanide
63212-31-7

o-lithiomethylphenyl isocyanide

3-(2-Isocyano-benzyl)-2-methyl-hexanoic acid ethyl ester

3-(2-Isocyano-benzyl)-2-methyl-hexanoic acid ethyl ester

Conditions
ConditionsYield
100%
methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

o-lithiomethylphenyl isocyanide

o-lithiomethylphenyl isocyanide

methyl 4-(o-isocyanophenyl)-3-propylbutyrate

methyl 4-(o-isocyanophenyl)-3-propylbutyrate

Conditions
ConditionsYield
100%
nitromethane
75-52-5

nitromethane

methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

methyl 3-(nitromethyl)hexanoate

methyl 3-(nitromethyl)hexanoate

Conditions
ConditionsYield
With 2-tert-butylimino-2-diethylamino-1,3-dimethylperhydro-1,3, 2-diazaphosphorine supported on polystyrene at 30℃; for 22h; Michael condensation;95%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In methanol Michael addition;
methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

tert-butyl (1S,4R)-2-(1-(N,N-diisopropylaminocarbonyl)-7,7-dimethyl-bicyclo[2.2.1]hept-2-ylideneamino)ethanoate

tert-butyl (1S,4R)-2-(1-(N,N-diisopropylaminocarbonyl)-7,7-dimethyl-bicyclo[2.2.1]hept-2-ylideneamino)ethanoate

1-tert-butyl methyl (2R,3S)-N-2-(((1S,4R)-1-(N,N-diisopropylaminocarbonyl)-7,7-dimethyl-bicyclo[2.2.1]heptan-2-ylidene)amino)-3-propyl-glutamate

1-tert-butyl methyl (2R,3S)-N-2-(((1S,4R)-1-(N,N-diisopropylaminocarbonyl)-7,7-dimethyl-bicyclo[2.2.1]heptan-2-ylidene)amino)-3-propyl-glutamate

Conditions
ConditionsYield
Stage #1: tert-butyl (1S,4R)-2-(1-(N,N-diisopropylaminocarbonyl)-7,7-dimethyl-bicyclo[2.2.1]hept-2-ylideneamino)ethanoate With n-butyllithium; diisopropylamine; lithium diisopropyl amide In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere; Cooling with acetone-dry ice;
Stage #2: methyl (E)-hex-2-enoate In tetrahydrofuran at -78℃; for 3h; Inert atmosphere;
Stage #3: With oxalic acid In tetrahydrofuran; water at 0℃; Inert atmosphere; diastereoselective reaction;
90%
methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

(1S,2S,5'S)-N,N-diisopropyl [2-spiro-2'-(5'-methyl-1',3'-dioxolane-4'-one)-7,7-dimethylbicyclo[2.2.1]hept-1-yl]methanesulfonamide
256393-10-9

(1S,2S,5'S)-N,N-diisopropyl [2-spiro-2'-(5'-methyl-1',3'-dioxolane-4'-one)-7,7-dimethylbicyclo[2.2.1]hept-1-yl]methanesulfonamide

(1S,2S,5'R,1''S)-N,N-diisopropyl-{7,7-dimethyl-2-spiro-2'-[5',5'-(2'-carbomethoxy-1''-propyl)ethylmethyl-1',3'-dioxolane-4'-one]}bicyclo[2.2.1]hept-1-ylmethanesulfonamide

(1S,2S,5'R,1''S)-N,N-diisopropyl-{7,7-dimethyl-2-spiro-2'-[5',5'-(2'-carbomethoxy-1''-propyl)ethylmethyl-1',3'-dioxolane-4'-one]}bicyclo[2.2.1]hept-1-ylmethanesulfonamide

Conditions
ConditionsYield
Stage #1: (1S,2S,5'S)-N,N-diisopropyl [2-spiro-2'-(5'-methyl-1',3'-dioxolane-4'-one)-7,7-dimethylbicyclo[2.2.1]hept-1-yl]methanesulfonamide With lithium diisopropyl amide In tetrahydrofuran; hexane at -100℃; for 0.5h;
Stage #2: methyl (E)-hex-2-enoate In tetrahydrofuran; hexane at -78℃; for 3h; Michael addition; Further stages.;
88%
methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

3-propylepoxyethane-2-carboxylic acid methyl ester

3-propylepoxyethane-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With 3-chloro-benzenecarboperoxoic acid In 1,2-dichloro-ethane at 50℃; for 3h;88%
methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

γ-bromo methyl-2-hexenoate
91664-06-1

γ-bromo methyl-2-hexenoate

Conditions
ConditionsYield
With N-Bromosuccinimide In tetrachloromethane87%
methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

[2-(4-Benzyloxy-phenyl)-ethyl]-((S)-1-phenyl-ethyl)-amine
267888-94-8

[2-(4-Benzyloxy-phenyl)-ethyl]-((S)-1-phenyl-ethyl)-amine

(S)-3-[[2-(4-Benzyloxy-phenyl)-ethyl]-((S)-1-phenyl-ethyl)-amino]-hexanoic acid methyl ester
267888-95-9

(S)-3-[[2-(4-Benzyloxy-phenyl)-ethyl]-((S)-1-phenyl-ethyl)-amino]-hexanoic acid methyl ester

Conditions
ConditionsYield
With n-butyllithium Addition;82%
methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

1-amino-2-propene
107-11-9

1-amino-2-propene

methyl 3-(N-allylamino)hexanoate

methyl 3-(N-allylamino)hexanoate

Conditions
ConditionsYield
In methanol for 8h; Heating;80%
methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

methylmagnesium bromide
75-16-1

methylmagnesium bromide

(S)-(-)-methyl 3-methylhexanoate
116169-10-9

(S)-(-)-methyl 3-methylhexanoate

Conditions
ConditionsYield
With copper(l) iodide; 1,1′-binaphthalene-2,2′-diylbis[bis(4-methylphenyl)phosphine] In diethyl ether; tert-butyl methyl ether at -20℃; for 2.5h; Inert atmosphere; optical yield given as %ee; enantioselective reaction;79%
methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

(R)-N-benzyl-1-phenylethylamine
38235-77-7

(R)-N-benzyl-1-phenylethylamine

methyl (+)-(3R,αR)-3-(N-benzyl-N-α-methylbenzylamino)hexanoate
210294-87-4

methyl (+)-(3R,αR)-3-(N-benzyl-N-α-methylbenzylamino)hexanoate

Conditions
ConditionsYield
Stage #1: (R)-N-benzyl-1-phenylethylamine With n-butyllithium In tetrahydrofuran; hexane at 0℃; for 0.25h;
Stage #2: methyl (E)-hex-2-enoate In tetrahydrofuran; hexane at -78℃;
77%
methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

ethylmagnesium bromide
925-90-6

ethylmagnesium bromide

4-bromo-aniline
106-40-1

4-bromo-aniline

(R)-N-(4-bromophenyl)-3-ethylhexanamide

(R)-N-(4-bromophenyl)-3-ethylhexanamide

Conditions
ConditionsYield
Stage #1: ethylmagnesium bromide With copper(I) bromide dimethylsulfide complex In diethyl ether; tert-butyl methyl ether at -75℃; for 0.0833333h; Schlenk technique; Inert atmosphere;
Stage #2: methyl (E)-hex-2-enoate In diethyl ether; tert-butyl methyl ether at -75℃; for 3h; Schlenk technique; Inert atmosphere;
Stage #3: 4-bromo-aniline In diethyl ether; tert-butyl methyl ether at -75 - 20℃; Schlenk technique; Inert atmosphere; enantioselective reaction;
77%
methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

cyclopenta-1,3-diene
542-92-7

cyclopenta-1,3-diene

methyl (1R,2S,3S,4S)-3-propylbicyclo[2.2.1]hept-5-ene-2-carboxylate

methyl (1R,2S,3S,4S)-3-propylbicyclo[2.2.1]hept-5-ene-2-carboxylate

Conditions
ConditionsYield
With triethyl((1-methoxy-2-methylprop-1-en-1-yl)oxy)silane; C74H33F30N3O8P2S2 In toluene at -80℃; for 30h; Diels-Alder Cycloaddition; Inert atmosphere; stereoselective reaction;76%
methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

(S)-2'-(1-Ethyl-1-methoxy-propyl)-[1,1']bipyrrolidinyl-2-one
181293-31-2

(S)-2'-(1-Ethyl-1-methoxy-propyl)-[1,1']bipyrrolidinyl-2-one

(2'S,R,R)-(-)-3-[2'-(1-ethyl-1-methoxypropyl)-2-oxobipyrrolidinyl-3-yl]-hexanoic acid methyl ester
263748-72-7

(2'S,R,R)-(-)-3-[2'-(1-ethyl-1-methoxypropyl)-2-oxobipyrrolidinyl-3-yl]-hexanoic acid methyl ester

Conditions
ConditionsYield
Stage #1: (S)-2'-(1-Ethyl-1-methoxy-propyl)-[1,1']bipyrrolidinyl-2-one With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 3h; Metallation;
Stage #2: methyl (E)-hex-2-enoate In tetrahydrofuran at -100 - -78℃; Addition;
70%
methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

ethylmagnesium bromide
925-90-6

ethylmagnesium bromide

aniline
62-53-3

aniline

(R)-3-ethyl-N-phenylhexanamide

(R)-3-ethyl-N-phenylhexanamide

Conditions
ConditionsYield
Stage #1: ethylmagnesium bromide With copper(I) bromide dimethylsulfide complex In diethyl ether; tert-butyl methyl ether at -75℃; for 0.0833333h; Schlenk technique; Inert atmosphere;
Stage #2: methyl (E)-hex-2-enoate In diethyl ether; tert-butyl methyl ether at -75℃; for 3h; Schlenk technique; Inert atmosphere;
Stage #3: aniline In diethyl ether; tert-butyl methyl ether at -75 - 20℃; Schlenk technique; Inert atmosphere; enantioselective reaction;
65%
methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-N,N-diisobutyl-2-nitroaniline

4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-N,N-diisobutyl-2-nitroaniline

(+/-)-methyl 3-(4-(diisobutylamino)-3-nitrophenyl)hexanoate

(+/-)-methyl 3-(4-(diisobutylamino)-3-nitrophenyl)hexanoate

Conditions
ConditionsYield
With chloro(1,5-cyclooctadiene)rhodium(I) dimer; sodium hydroxide In 1,4-dioxane at 50℃; Inert atmosphere;64.2%
methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

(1Z,3Z)-[1-methyloxy-1,3-hexadienyloxy]tert-butyldimethylsilane
287193-98-0

(1Z,3Z)-[1-methyloxy-1,3-hexadienyloxy]tert-butyldimethylsilane

Conditions
ConditionsYield
With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78 - 20℃; for 0.666667h; silylation;61%
Stage #1: methyl (E)-hex-2-enoate With potassium hexamethylsilazane In tetrahydrofuran at -78℃; for 1.33333h; Inert atmosphere;
Stage #2: tert-butyldimethylsilyl chloride In tetrahydrofuran at -78 - 20℃; Inert atmosphere;
methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

acetoacetic acid methyl ester
105-45-3

acetoacetic acid methyl ester

dimethyl 2-acetyl-3-propylglutarate

dimethyl 2-acetyl-3-propylglutarate

Conditions
ConditionsYield
With sodium methylate In methanol for 72h; Heating;60%
Phenylselenyl chloride
5707-04-0

Phenylselenyl chloride

methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

benzylamine
100-46-9

benzylamine

3-benzylamino-2-phenylselanyl-hexanoic acid methyl ester

3-benzylamino-2-phenylselanyl-hexanoic acid methyl ester

Conditions
ConditionsYield
Stage #1: Phenylselenyl chloride; methyl (E)-hex-2-enoate With zinc(II) chloride In dichloromethane at 20℃; for 0.5h; Addition;
Stage #2: benzylamine at 20℃; for 14h; Alkylation;
59%
methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

A

C7H11BrO2
931382-07-9

C7H11BrO2

B

C7H11BrO2
931382-06-8

C7H11BrO2

Conditions
ConditionsYield
Stage #1: methyl (E)-hex-2-enoate With bromine In n-heptane at 20℃; for 1h; Inert atmosphere;
Stage #2: With potassium carbonate In n-heptane; acetonitrile at 60℃; for 2h; Inert atmosphere;
A 57%
B 18%
methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

benzylamine
100-46-9

benzylamine

rac-methyl 3-(benzylamino)hexanoate

rac-methyl 3-(benzylamino)hexanoate

Conditions
ConditionsYield
Stage #1: methyl (E)-hex-2-enoate With bismuth (III) nitrate pentahydrate at 0℃; for 0.0833333h;
Stage #2: benzylamine
57%
methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

ethylmagnesium bromide
925-90-6

ethylmagnesium bromide

benzyl-methyl-amine
103-67-3

benzyl-methyl-amine

(R)-N-benzyl-3-ethyl-N-methylhexanamide

(R)-N-benzyl-3-ethyl-N-methylhexanamide

Conditions
ConditionsYield
Stage #1: ethylmagnesium bromide With copper(I) bromide dimethylsulfide complex In diethyl ether; tert-butyl methyl ether at -75℃; for 0.0833333h; Schlenk technique; Inert atmosphere;
Stage #2: methyl (E)-hex-2-enoate In diethyl ether; tert-butyl methyl ether at -75℃; for 3h; Schlenk technique; Inert atmosphere;
Stage #3: benzyl-methyl-amine In diethyl ether; tert-butyl methyl ether at -75 - 20℃; Schlenk technique; Inert atmosphere; enantioselective reaction;
54%
methyl (cis-(3S,4R)-3,4-isopropylidenedioxypyrrolidin-2-ylidene)acetate

methyl (cis-(3S,4R)-3,4-isopropylidenedioxypyrrolidin-2-ylidene)acetate

methyl (E)-hex-2-enoate
13894-63-8

methyl (E)-hex-2-enoate

A

methyl (1S,2R,7R)-1,2-isopropylidenedioxy-7-propyl-1,2,3,5,6,7-hexahydro-5-indolizinone-8-carboxylate
933776-59-1

methyl (1S,2R,7R)-1,2-isopropylidenedioxy-7-propyl-1,2,3,5,6,7-hexahydro-5-indolizinone-8-carboxylate

B

methyl (1S,2R,7S)-1,2-isopropylidenedioxy-7-propyl-1,2,3,5,6,7-hexahydro-5-indolizinone-8-carboxylate
933776-43-3

methyl (1S,2R,7S)-1,2-isopropylidenedioxy-7-propyl-1,2,3,5,6,7-hexahydro-5-indolizinone-8-carboxylate

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran at 25℃; for 4h;A 33%
B 52%

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