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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

METHYL 5-AMINOTHIOPHENE-2-CARBOXYLATE

Cas:14597-58-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

2-Thiophenecarboxylicacid, 5-amino-, methyl ester

Cas:14597-58-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-Thiophenecarboxylicacid, 5-amino-, methyl ester

Cas:14597-58-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products 5-Amino-thiophene-2-carboxylic acid methyl ester

Cas:14597-58-1

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

2-Thiophenecarboxylicacid, 5-amino-, methyl ester

Cas:14597-58-1

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

5-Amino-thiophene-2-carboxylic acid methyl ester

Cas:14597-58-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

5-Amino-thiophene-2-carboxylic acid methyl ester

Cas:14597-58-1

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Methyl 5-aminothiophene-2-carboxylate

Cas:14597-58-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

SAGECHEM/5-Amino-thiophene-2-carboxylic acid methyl ester

Cas:14597-58-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

5-Amino-Thiophene-2-Carboxylic Acid Methyl Ester cas no. 14597-58-1 98%

Cas:14597-58-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

5-Amino-thiophene-2-carboxylic acid methyl ester

Cas:14597-58-1

Min.Order:0

Negotiable

Type:Other

inquiry

Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

5-Amino-thiophene-2-carboxylic acid methyl ester

Cas:14597-58-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

factory?direct?sale Application:healing drugs

2-Thiophenecarboxylicacid, 5-amino-, methyl ester

Cas:14597-58-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU TIANYE CHEMICALS CO., LTD.

"HANGZHOU TIANYE CHEMICALS Co.LTD , Located in Eastern Science and Innovation Park Hangzhou .We are a high-tech enterprise specialized in technical research and development, production, development and trade of chemical products. We supply Multiple s

Methyl 5-aminothiophene-2-carboxylate

Cas:14597-58-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Best quality with low price Storage:ln stock Package:25kg/Barrel Application:Chemicals Transportation:Express/Sea/Air Port:Shanghai

5-Amino-thiophene-2-carboxylicacidmethylester

Cas:14597-58-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hunan Russell Chemicals Technology Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China

Methyl 5-aminothiophene-2-carboxylate 14597-58-1

Cas:14597-58-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemsigma International Co.,Ltd.

bulk?production Application:Pharmaceutical intermediates

5-Amino-thiophene-2-carboxylic acid methyl ester

Cas:14597-58-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

5-Amino-thiophene-2-carboxylic acid methyl ester

Cas:14597-58-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

LEAP CHEM Co., Ltd.

Best Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP

5-Aminothiophene-2-carboxylic acid methyl ester

Cas:14597-58-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Bide Pharmatech Ltd

Our mission is to provide high-quality and innovative products to our customers. By offering a broad range of products, custom synthesis and personalized services, Bide can help scientists speeding up their research in the chemical and pharmaceutical

Methyl 5-aminothiophene-2-carboxylate

Cas:14597-58-1

Min.Order:0

Negotiable

Type:Other

inquiry

Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

5-Aminothiophene-2-carboxylicacidmethylester

Cas:14597-58-1

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Yinghao Pharm Co.,Ltd.

Yinghao Pharm products include: leader molecule, heterocyclic compounds,chiral compounds, photoelectric materials, biochemical reagents etc. For example:benzene, pyrimidine, boricacid,pyridine, pyrazole, imidazole, pyrrole, fluorine and other derivat

5-Aminothiophene-2-carboxylic acid methyl ester

Cas:14597-58-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Nanjing Norris Pharm Technology Co., Ltd.

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

5-Amino-thiophene-2-carboxylic acid methyl ester

Cas:14597-58-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Capot Chemical Co., Ltd.

At Capot,We can synthesize and purify your complex molecules from 100 gram to 10 tons.Appearance:Clear colorless to light yellow liquid Storage:Dry,Seal and Cool place Package:1G,5G,10G,25G,100G,250G,500G,1KG,5KG,10KG,25KG,50KG,100KG,150KG,200KG. App

5-Aminothiophene-2-carboxylic acid methyl ester

Cas:14597-58-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

coolpharm Ltd

Cool Pharm Ltd, found in 2383,is a high-tech enterprise which provides customer synthesis service for domestic and international pharmaceutical companies according to international standards. Our business includes research , development, process opti

METHYL5-AMINOTHIOPHENE-2-CARBOXYLATE

Cas:14597-58-1

Min.Order:0

Negotiable

Type:Other

inquiry

Pure Chemistry Scientific Inc.

Methyl 5-aminothiophene-2-carboxylate Application:80073537

Methyl 5-aminothiophene-2-carboxylate

Cas:14597-58-1

Min.Order:1 Gram

FOB Price: $500.0

Type:Trading Company

inquiry

Shanghai Run-Biotech Co., Ltd.

Shanghai, Run-Biotech Co., Ltd is a leading domestic pharmaceutical, biopharmaceutical, and health care products R & D outsourcing services company. As an innovation-driven and customer-focused company, Run Biotech provides a broad and integrated por

5-Aminothiophene-2-carboxylic acid methyl ester

Cas:14597-58-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Wuxi Morality Chemical Co., Ltd

Do best quality products, erect the morality model Application:please email us, thanks

5-Amino-thiophene-2-carboxylic acid methyl ester

Cas:14597-58-1

Min.Order:0

Negotiable

Type:Other

inquiry

Skyrun Industrial Co.,Ltd

Good Price, high main content Application:Medical intermediate; Used in organic synthesis

5-Amino-thiophene-2-carboxylic acid methyl ester

Cas:14597-58-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Finetech Industry Limited

High Quality Best Price Storage:Store in dry, dark and ventilated place Application:Chemical Synthesis Intermediate

FT-0697699

Cas:14597-58-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

methyl 5-nitrothiophene-2-carboxylate
5832-01-9

methyl 5-nitrothiophene-2-carboxylate

methyl 5-aminothiophene-2-carboxylate
14597-58-1

methyl 5-aminothiophene-2-carboxylate

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In ethyl acetate at 20℃; for 2h;100%
With hydrogen; palladium 10% on activated carbon In ethanol under 760.051 Torr;92%
Stage #1: methyl 5-nitrothiophene-2-carboxylate With hydrogenchloride; tin(ll) chloride In ethanol; water at 20 - 35℃; for 2h;
Stage #2: In water pH=9; basic conditions;
66%
methanol
67-56-1

methanol

2-thiophenylcarboxylic acid
527-72-0

2-thiophenylcarboxylic acid

A

methyl 5-aminothiophene-2-carboxylate
14597-58-1

methyl 5-aminothiophene-2-carboxylate

B

methyl 4-aminothiophene-2-carboxylate
89499-43-4

methyl 4-aminothiophene-2-carboxylate

Conditions
ConditionsYield
Stage #1: 2-thiophenylcarboxylic acid With sulfuric acid; nitric acid at 0 - 10℃; for 1.25h;
Stage #2: methanol With thionyl chloride at 20℃; Reflux;
A 8.5%
B 31%
5-nitrothiophene-2-carboxylic acid
6317-37-9

5-nitrothiophene-2-carboxylic acid

methyl 5-aminothiophene-2-carboxylate
14597-58-1

methyl 5-aminothiophene-2-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: SOCl2
2: Fe; AcOH
View Scheme
Multi-step reaction with 3 steps
1: thionyl chloride / 1,2-dichloro-ethane / 0.5 h / 150 °C / Microwave irradiation
2: dichloromethane / 0 - 20 °C
3: 20 % Pd(OH)2/C; hydrogen / ethanol
View Scheme
Multi-step reaction with 2 steps
1: methanol / Reflux
2: ammonium formate; zinc / ethanol; ethyl acetate
View Scheme
methyl 5-nitrothiophene-2-carboxylate
5832-01-9

methyl 5-nitrothiophene-2-carboxylate

methyl 5-aminothiophene-2-carboxylate
14597-58-1

methyl 5-aminothiophene-2-carboxylate

Conditions
ConditionsYield
In methanol; water
2-thiophenylcarboxylic acid
527-72-0

2-thiophenylcarboxylic acid

A

methyl 5-aminothiophene-2-carboxylate
14597-58-1

methyl 5-aminothiophene-2-carboxylate

B

methyl 4-aminothiophene-2-carboxylate
89499-43-4

methyl 4-aminothiophene-2-carboxylate

Conditions
ConditionsYield
Stage #1: 2-thiophenylcarboxylic acid With sulfuric acid; nitric acid at 0 - 10℃;
Stage #2: With methanol; thionyl chloride at 20℃; Reflux;
Stage #3: With hydrogenchloride; iron; ammonium chloride In methanol; water at 20 - 70℃;
5-nitrothiophene-2-carbonyl chloride
39978-57-9

5-nitrothiophene-2-carbonyl chloride

methyl 5-aminothiophene-2-carboxylate
14597-58-1

methyl 5-aminothiophene-2-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dichloromethane / 0 - 20 °C
2: 20 % Pd(OH)2/C; hydrogen / ethanol
View Scheme
methyl 5-aminothiophene-2-carboxylate
14597-58-1

methyl 5-aminothiophene-2-carboxylate

1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde
4869-46-9

1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde

C13H13N3O4S
1177471-31-6

C13H13N3O4S

Conditions
ConditionsYield
With acetic acid for 6h; Reflux;94%
methyl 5-aminothiophene-2-carboxylate
14597-58-1

methyl 5-aminothiophene-2-carboxylate

C17H25N5O3SSi
1094070-49-1

C17H25N5O3SSi

C22H28N6O3SSi
1094071-35-8

C22H28N6O3SSi

Conditions
ConditionsYield
Stage #1: methyl 5-aminothiophene-2-carboxylate; C17H25N5O3SSi With sodium hydride In dimethyl sulfoxide at 20℃; for 0.166667h;
Stage #2: With water; ammonium chloride In dimethyl sulfoxide
85%
With sodium hydride In N,N-dimethyl-formamide at 20℃;
methyl 5-aminothiophene-2-carboxylate
14597-58-1

methyl 5-aminothiophene-2-carboxylate

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

2-carbomethoxy-4-trifluoromethylthieno[2,3-b]pyridin-6-one
380419-63-6

2-carbomethoxy-4-trifluoromethylthieno[2,3-b]pyridin-6-one

Conditions
ConditionsYield
In acetic acid Heating;84%
methyl 5-aminothiophene-2-carboxylate
14597-58-1

methyl 5-aminothiophene-2-carboxylate

1,1,1-trifluoro-4-(2-thienyl)butane-2,4-dione
326-91-0

1,1,1-trifluoro-4-(2-thienyl)butane-2,4-dione

6-thiophen-2-yl-4-trifluoromethyl-thieno[2,3-b]pyridine-2-carboxylic acid methyl ester

6-thiophen-2-yl-4-trifluoromethyl-thieno[2,3-b]pyridine-2-carboxylic acid methyl ester

Conditions
ConditionsYield
In acetic acid Heating;78%
methyl 5-aminothiophene-2-carboxylate
14597-58-1

methyl 5-aminothiophene-2-carboxylate

N-(1-chloro-2,2,2-trifluoroethylidene)-O-methylurethane
126855-73-0

N-(1-chloro-2,2,2-trifluoroethylidene)-O-methylurethane

5-{2,2,2-Trifluoro-1-[(Z)-methoxycarbonylimino]-ethylamino}-thiophene-2-carboxylic acid methyl ester

5-{2,2,2-Trifluoro-1-[(Z)-methoxycarbonylimino]-ethylamino}-thiophene-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With triethylamine In benzene at 20℃; for 2h;78%
methyl 5-aminothiophene-2-carboxylate
14597-58-1

methyl 5-aminothiophene-2-carboxylate

3,3-dimethoxy-2-formyl-propanenitrile sodium salt
105161-33-9

3,3-dimethoxy-2-formyl-propanenitrile sodium salt

methyl 5-cyanothieno[2,3-b]pyridine-2-carboxylate

methyl 5-cyanothieno[2,3-b]pyridine-2-carboxylate

Conditions
ConditionsYield
Stage #1: methyl 5-aminothiophene-2-carboxylate; 3,3-dimethyloxy-2-formylpropionitrile sodium salt With hydrogenchloride In methanol; water at 20℃; for 4h;
Stage #2: With hydrogenchloride In methanol; water at 20℃; for 12h;
78%
methyl 5-aminothiophene-2-carboxylate
14597-58-1

methyl 5-aminothiophene-2-carboxylate

C9H8BrF2NO2

C9H8BrF2NO2

methyl 5-(3-(difluoromethoxy)-2-nitrophenylamino)thiophene-2-carboxylate
1314091-77-4

methyl 5-(3-(difluoromethoxy)-2-nitrophenylamino)thiophene-2-carboxylate

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 80 - 90℃; for 0.25h; Inert atmosphere;77.5%
methyl 5-aminothiophene-2-carboxylate
14597-58-1

methyl 5-aminothiophene-2-carboxylate

3-fluoro-2-nitrobenzonitrile
1000339-52-5

3-fluoro-2-nitrobenzonitrile

methyl 5-(3-cyano-2-nitrophenylamino)thiophene-2-carboxylate
1314092-14-2

methyl 5-(3-cyano-2-nitrophenylamino)thiophene-2-carboxylate

Conditions
ConditionsYield
With triethylbutylammonium chloride; potassium hydroxide In N,N-dimethyl-formamide Cooling with ice;77%
methyl 5-aminothiophene-2-carboxylate
14597-58-1

methyl 5-aminothiophene-2-carboxylate

1-Phenyl-4,4,4-trifluorobutane-1,3-dione
326-06-7

1-Phenyl-4,4,4-trifluorobutane-1,3-dione

6-phenyl-4-trifluoromethyl-thieno[2,3-b]pyridine-2-carboxylic acid methyl ester

6-phenyl-4-trifluoromethyl-thieno[2,3-b]pyridine-2-carboxylic acid methyl ester

Conditions
ConditionsYield
In acetic acid Heating;73%
methyl 5-aminothiophene-2-carboxylate
14597-58-1

methyl 5-aminothiophene-2-carboxylate

methyl N-(1,2,2,2-tetrachloroethylidene)urethan
111335-09-2

methyl N-(1,2,2,2-tetrachloroethylidene)urethan

5-{2,2,2-Trichloro-1-[(Z)-methoxycarbonylimino]-ethylamino}-thiophene-2-carboxylic acid methyl ester

5-{2,2,2-Trichloro-1-[(Z)-methoxycarbonylimino]-ethylamino}-thiophene-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With triethylamine In benzene at 20℃; for 2h;73%
methyl 5-aminothiophene-2-carboxylate
14597-58-1

methyl 5-aminothiophene-2-carboxylate

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

methyl 5-((tert-butoxycarbonyl)amino)thiophene-2-carboxylate
666853-39-0

methyl 5-((tert-butoxycarbonyl)amino)thiophene-2-carboxylate

Conditions
ConditionsYield
In tetrahydrofuran for 48h; Reflux;68%
In tetrahydrofuran for 72h; Heating / reflux;
at 110℃; for 1.5h; Inert atmosphere;
methyl 5-aminothiophene-2-carboxylate
14597-58-1

methyl 5-aminothiophene-2-carboxylate

2-(2-tert-butylphenoxy)-3-isocyanatopyridine
870072-76-7

2-(2-tert-butylphenoxy)-3-isocyanatopyridine

methyl 5-(3-(2-(2-(tert-butyl)phenoxy)pyridin-3-yl)ureido)thiophene-2-carboxylate

methyl 5-(3-(2-(2-(tert-butyl)phenoxy)pyridin-3-yl)ureido)thiophene-2-carboxylate

Conditions
ConditionsYield
In toluene at 80℃; for 1.5h; Microwave irradiation;63%
methyl 5-aminothiophene-2-carboxylate
14597-58-1

methyl 5-aminothiophene-2-carboxylate

N-(2-bromo-6-methylphenyl)acetamide
116436-11-4

N-(2-bromo-6-methylphenyl)acetamide

methyl 5-(2,4-dimethyl-1H-benzo[d]imidazol-1-yl)thiophene-2-carboxylate

methyl 5-(2,4-dimethyl-1H-benzo[d]imidazol-1-yl)thiophene-2-carboxylate

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); potassium phosphate monohydrate; bis(2',6'-diisopropoxybiphenyl)cyclohexylphosphine In tert-butyl alcohol at 120℃; for 2h; Molecular sieve; Microwave irradiation;61%
methyl 5-aminothiophene-2-carboxylate
14597-58-1

methyl 5-aminothiophene-2-carboxylate

1,3-bis(tert-butoxycarbonyl)-2-methyl-2-thiopseudourea
322474-21-5, 107819-90-9

1,3-bis(tert-butoxycarbonyl)-2-methyl-2-thiopseudourea

methyl 5-{[(1E)-{[(tert-butoxy)carbonyl]amino}({[(tert-butoxy)carbonyl]imino}) methyl]amino}thiophene-2-carboxylate

methyl 5-{[(1E)-{[(tert-butoxy)carbonyl]amino}({[(tert-butoxy)carbonyl]imino}) methyl]amino}thiophene-2-carboxylate

Conditions
ConditionsYield
With triethylamine; mercury dichloride In N,N-dimethyl-formamide at 20℃;53%
With triethylamine; mercury dichloride In N,N-dimethyl-formamide at 20℃;
methyl 5-aminothiophene-2-carboxylate
14597-58-1

methyl 5-aminothiophene-2-carboxylate

(N-methyl)benzimidoyl chloride
41890-17-9

(N-methyl)benzimidoyl chloride

2-methoxycarbonyl-5-(α-methylaminobenzylidene)aminothiophene
380416-72-8

2-methoxycarbonyl-5-(α-methylaminobenzylidene)aminothiophene

Conditions
ConditionsYield
With triethylamine In benzene at 25℃; for 12h;47%
methyl 5-aminothiophene-2-carboxylate
14597-58-1

methyl 5-aminothiophene-2-carboxylate

2-dimethylaminomethylene-1,3-bis(dimethylimonio)propane diperchlorate
2009-81-6

2-dimethylaminomethylene-1,3-bis(dimethylimonio)propane diperchlorate

methyl 5-formylthieno[2,3-b]pyridine-2-carboxylate

methyl 5-formylthieno[2,3-b]pyridine-2-carboxylate

Conditions
ConditionsYield
With sodium methylate In methanol for 12h; Reflux;43%
methyl 5-aminothiophene-2-carboxylate
14597-58-1

methyl 5-aminothiophene-2-carboxylate

tert-butyl N-[(tert-butoxy)carbonyl]-N-(6-chloro-4-methylpyridazin-3-yl)carbamate

tert-butyl N-[(tert-butoxy)carbonyl]-N-(6-chloro-4-methylpyridazin-3-yl)carbamate

methyl 5-[(6-{bis[(tert-butoxy)carbonyl]amino}-5-methylpyridazin-3-yl)amino]thiophene-2-carboxylate

methyl 5-[(6-{bis[(tert-butoxy)carbonyl]amino}-5-methylpyridazin-3-yl)amino]thiophene-2-carboxylate

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene at 100℃; Inert atmosphere;41%
methyl 5-aminothiophene-2-carboxylate
14597-58-1

methyl 5-aminothiophene-2-carboxylate

1-[(tert-butoxy)carbonyl]-4-[(dimethylamino)methyl]piperidine-4-carboxylic acid

1-[(tert-butoxy)carbonyl]-4-[(dimethylamino)methyl]piperidine-4-carboxylic acid

tert-butyl 4-[(dimethylamino)methyl]-4-{[5-(methoxycarbonyl)thiophen-2-yl]carbamoyl}piperidine-1-carboxylate

tert-butyl 4-[(dimethylamino)methyl]-4-{[5-(methoxycarbonyl)thiophen-2-yl]carbamoyl}piperidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: 1-[(tert-butoxy)carbonyl]-4-[(dimethylamino)methyl]piperidine-4-carboxylic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: methyl 5-aminothiophene-2-carboxylate In N,N-dimethyl-formamide at 30℃; for 18h;
39%
2-amino-4,5,6,7,8,9-hexahydro-cycloocta[b]thiophene-3-carboxylic acid isopropyl ester
910472-18-3

2-amino-4,5,6,7,8,9-hexahydro-cycloocta[b]thiophene-3-carboxylic acid isopropyl ester

methyl 5-aminothiophene-2-carboxylate
14597-58-1

methyl 5-aminothiophene-2-carboxylate

bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

2-[3-(3-methoxycarbonyl-thiophen-2-yl)-ureido]-4,5,6,7,8,9-hexahydro-cycloocta[b]thiophene-3-carboxylic acid isopropyl ester

2-[3-(3-methoxycarbonyl-thiophen-2-yl)-ureido]-4,5,6,7,8,9-hexahydro-cycloocta[b]thiophene-3-carboxylic acid isopropyl ester

Conditions
ConditionsYield
Stage #1: 2-amino-4,5,6,7,8,9-hexahydro-cycloocta[b]thiophene-3-carboxylic acid isopropyl ester; bis(trichloromethyl) carbonate With triethylamine In dichloromethane at 20℃; for 2h;
Stage #2: methyl 5-aminothiophene-2-carboxylate In dichloromethane at 20℃; for 1h;
27%
methyl 5-aminothiophene-2-carboxylate
14597-58-1

methyl 5-aminothiophene-2-carboxylate

racemic (2'R,3R,3'S,5'S)-6-chloro-3'-(3-chloro-2-fluoro-phenyl)-5'-(2-cyano-2-methyl-propyl)-2-oxo-spiro[indoline-3,4'-pyrrolidine]-2'-carboxylic acid

racemic (2'R,3R,3'S,5'S)-6-chloro-3'-(3-chloro-2-fluoro-phenyl)-5'-(2-cyano-2-methyl-propyl)-2-oxo-spiro[indoline-3,4'-pyrrolidine]-2'-carboxylic acid

methyl rac-5-[[(2'R,3R,3'S,5'S)-6-chloro-3'-(3-chloro-2-fluoro-phenyl)-5'-(2-cyano-2-methyl-propyl)-2-oxo-spiro[indoline-3,4'-pyrrolidine]-2'-carbonyl]amino]thiophene-2-carboxylate

methyl rac-5-[[(2'R,3R,3'S,5'S)-6-chloro-3'-(3-chloro-2-fluoro-phenyl)-5'-(2-cyano-2-methyl-propyl)-2-oxo-spiro[indoline-3,4'-pyrrolidine]-2'-carbonyl]amino]thiophene-2-carboxylate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃;8.7%
methyl 5-aminothiophene-2-carboxylate
14597-58-1

methyl 5-aminothiophene-2-carboxylate

5-benzoylimino-4,5-dihydro-thiophene-2-carboxylic acid methyl ester

5-benzoylimino-4,5-dihydro-thiophene-2-carboxylic acid methyl ester

methyl 5-aminothiophene-2-carboxylate
14597-58-1

methyl 5-aminothiophene-2-carboxylate

benzyl isothiocyanate
3173-56-6

benzyl isothiocyanate

5-(3-benzyl-ureido)-thiophene-2-carboxylic acid methyl ester
304696-16-0

5-(3-benzyl-ureido)-thiophene-2-carboxylic acid methyl ester

methyl 5-aminothiophene-2-carboxylate
14597-58-1

methyl 5-aminothiophene-2-carboxylate

4-oxo-2-trichloromethyl-3,4-dihydro-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester

4-oxo-2-trichloromethyl-3,4-dihydro-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 73 percent / Et3N / benzene / 2 h / 20 °C
2: 79 percent / toluene / 3 h / 110 °C
View Scheme
methyl 5-aminothiophene-2-carboxylate
14597-58-1

methyl 5-aminothiophene-2-carboxylate

4-oxo-2-trifluoromethyl-3,4-dihydro-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester

4-oxo-2-trifluoromethyl-3,4-dihydro-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 78 percent / Et3N / benzene / 2 h / 20 °C
2: 76 percent / toluene / 3 h / 110 °C
View Scheme
methyl 5-aminothiophene-2-carboxylate
14597-58-1

methyl 5-aminothiophene-2-carboxylate

C10H5Cl2F3NO4PS

C10H5Cl2F3NO4PS

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 84 percent / acetic acid / Heating
2: POCl3 / 3 h / Heating
View Scheme
methyl 5-aminothiophene-2-carboxylate
14597-58-1

methyl 5-aminothiophene-2-carboxylate

2-carbomethoxy-4-trifluoromethylthieno[2,3-b]pyridin-6-yl dimethylphosphate

2-carbomethoxy-4-trifluoromethylthieno[2,3-b]pyridin-6-yl dimethylphosphate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 84 percent / acetic acid / Heating
2: POCl3 / 3 h / Heating
3: Et3N / benzene / 1.5 h / 20 °C
View Scheme
methyl 5-aminothiophene-2-carboxylate
14597-58-1

methyl 5-aminothiophene-2-carboxylate

6-pyrrolidin-1-yl-4-trifluoromethyl-thieno[2,3-b]pyridine-2-carboxylic acid methyl ester

6-pyrrolidin-1-yl-4-trifluoromethyl-thieno[2,3-b]pyridine-2-carboxylic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 84 percent / acetic acid / Heating
2: 73 percent / Et3N / dioxane / 16 h / Heating
3: 75 percent / i-Pr2NEt / dioxane / Heating
View Scheme

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