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Shandong Kehui Pharmaceutical Co., Ltd

Shandong Kehui Pharmaceutical Co., Ltd. is a modern high-tech pharmaceutical company that strictly complies with GMP requirements and produces high standards. The company was established in May 2017 and is located in the Yellow River Delta Medicine V

Vorinostat

Cas:149647-78-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Vorinostat Manufacturer/High quality/Best price/In stock

Cas:149647-78-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Suberoylanilide hydroxamic acid supplier in China

Cas:149647-78-9

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Vorinostat Cas 149647-78-9 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White or almost white powder Storage:-20°C Freezer Package:10g,100g,1kg/foil

Factory supply Vorinostat Cas 149647-78-9 with best price and fast delivery

Cas:149647-78-9

Min.Order:10 Gram

FOB Price: $7.0 / 10.0

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Vorinostat

Cas:149647-78-9

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Vorinostat 149647-78-9 GMP Manufacturer

Cas:149647-78-9

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Vorinostat

Cas:149647-78-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Vorinostat

Cas:149647-78-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--149647-78-9--High purity Vorinostat in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business re

TIANFUCHEM--149647-78-9--High purity Vorinostat in stock

Cas:149647-78-9

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu

Vorinostat CAS:149647-78-9

Cas:149647-78-9

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 149647-78-9 with best quality

Cas:149647-78-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Vorinostat/ LIDE PHARMA- Factory supply / Best price

Cas:149647-78-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Name: Vorinostat Synonyms: Octanediamide, N-hydroxy-N'-phenyl- CAS:149647-78-9 MF: C14H20N2O3 Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:25kg/drum Application: Pharmaceutical Intermediate T

Vorinostat

Cas:149647-78-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED

Octanediamide,N1-hydroxy-N8-phenyl-CAS NO.: 149647-78-9

Cas:149647-78-9

Min.Order:1 Gram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:White or off white powder Storage:R.T Package:1kg/Bag Application:A deacetylase inhibitor Transportation:Express/Sea/Air Port:Any port in China

High quality 99% Vorinostat (SAHA) in china

Cas:149647-78-9

Min.Order:1 Kilogram

FOB Price: $2000.0 / 4300.0

Type:Lab/Research institutions

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

1.Prompt Goods; 2.Flexible payment terms; 3.Documents & Certificate support. Name: Vorinostat Molecular Structure: Formula: C14H20N2O3 Molecular Weight : 264.32 Synonyms: CS-1949;SAHAcpd;UNII-58IFB293JI;Vornostat;Octanediamide,N1-hydroxy-

Factory Supply Vorinostat

Cas:149647-78-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Octanediamide,N1-hydroxy-N8-phenyl- 149647-78-9

Cas:149647-78-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Shanghai Minstar Chemical Co., Ltd

Product Name: Vorinostat Synonyms: CS-1949;SAHA cpd;UNII-58IFB293JI;Vornostat;Octanediamide, N1-hydroxy-N8-phenyl-;SAHA=N-Hydroxy-N'-phenyloctanediamide;SAHA, N-Hydroxy-Nphenyloctanediamide, Zolinza;Zolinza (See Suberoylanilide Hydroxamic A

Vorinostat

Cas:149647-78-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Vorinostat

Cas:149647-78-9

Min.Order:10 Gram

FOB Price: $8.0 / 10.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Vorinostat CAS:149647-78-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

Vorinostat CAS:149647-78-9

Cas:149647-78-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Vorinostat

Cas:149647-78-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

API name: Vorinostat Certificates: GMP, DMF CAS No.: 149647-78-9 Chemical name: SAHA M344 Vorinostat/SAHA Vorinostat Zolinza Formula: C14H20N2O3 Structure: Appearance:White or off white powder Storage:Store sealed at room

Vorinostat

Cas:149647-78-9

Min.Order:1 Kilogram

FOB Price: $100.0

Type:Trading Company

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

Vorinostat

Cas:149647-78-9

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Lab/Research institutions

inquiry

DB BIOTECH CO., LTD

Q1: Are you a manufacturer?Answer: Yes, we are factory founded on 2002. Q2: How to contact with us?Click "contact supplier" And then send us message the product you interest in, you will get reply within 12 hours. Q3:Which kind of payment terms do yo

Vorinostat

Cas:149647-78-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Vorinostat

Cas:149647-78-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Business Custom Synthesis: Trading(Raw Mater

Vorinostat

Cas:149647-78-9

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

MK-0683 Vorinostat 149647-78-9

Cas:149647-78-9

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

suberoylamide hydroxamic acid

Cas:149647-78-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

Vorinostat

Cas:149647-78-9

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

7-phenylcarbamoyl heptanoic acid methyl ester
162853-41-0

7-phenylcarbamoyl heptanoic acid methyl ester

vorinostat
149647-78-9

vorinostat

Conditions
ConditionsYield
Stage #1: 7-phenylcarbamoyl heptanoic acid methyl ester With hydroxylamine hydrochloride; sodium methylate In methanol; water for 16.1667h;
Stage #2: With water; acetic acid In methanol for 0.166667h; pH=8.7 - 12.02;
95.6%
With hydroxylamine hydrochloride; sodium methylate In methanol for 16.1667h;95.6%
Stage #1: 7-phenylcarbamoyl heptanoic acid methyl ester With hydroxylamine hydrochloride; sodium methylate In methanol for 16.3333h;
Stage #2: With sodium methylate In methanol; water for 0.166667h; pH=12.01 - 12.02;
Stage #3: With acetic acid In methanol; water pH=8.70 - 8.98; Product distribution / selectivity;
95.6%
C21H24N2O3

C21H24N2O3

vorinostat
149647-78-9

vorinostat

Conditions
ConditionsYield
With 10 wt% Pd(OH)2 on carbon; hydrogen; trifluoroacetic acid In methanol at 20℃; for 2h;91%
N-phenylhexanamide
6998-10-3

N-phenylhexanamide

vorinostat
149647-78-9

vorinostat

Conditions
ConditionsYield
With hydroxylamine hydrochloride In N,N-dimethyl-formamide at 40℃; for 1h; Reagent/catalyst;88.5%
8-(hydroxyamino)-8-oxooctanoic acid
149647-86-9

8-(hydroxyamino)-8-oxooctanoic acid

aniline
62-53-3

aniline

vorinostat
149647-78-9

vorinostat

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide; potassium hydroxide In ethanol at 50℃; for 0.5h;82.4%
With dicyclohexyl-carbodiimide; 1,1'-carbonyldiimidazole In tetrahydrofuran
suberanilic acid
149648-52-2

suberanilic acid

vorinostat
149647-78-9

vorinostat

Conditions
ConditionsYield
With C36H24B4N2O3; hydroxylamine hydrochloride; triethylamine In toluene at 80℃; for 14h; Molecular sieve;82%
Stage #1: suberanilic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 25 - 30℃; for 0.5h;
Stage #2: With hydroxylamine hydrochloride In N,N-dimethyl-formamide for 0.5h;
75%
Stage #1: suberanilic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 25 - 30℃; for 0.5h;
Stage #2: With hydroxylamine hydrochloride In N,N-dimethyl-formamide for 0.5h;
75%
7-phenylcarbamoyl heptanoic acid methyl ester
162853-41-0

7-phenylcarbamoyl heptanoic acid methyl ester

A

suberanilic acid
149648-52-2

suberanilic acid

B

vorinostat
149647-78-9

vorinostat

Conditions
ConditionsYield
With water; hydroxylamine; sodium methylate In methanol at 90℃;A 15%
B 80%
C17H23NO5

C17H23NO5

vorinostat
149647-78-9

vorinostat

Conditions
ConditionsYield
With hydroxylamine In methanol
With hydroxylamine hydrochloride; potassium hydroxide In methanol at 20℃; for 0.25h;
Multi-step reaction with 4 steps
1: sodium tetrahydroborate / methanol / 0.5 h / 0 °C
2: Dess-Martin periodane / dichloromethane / 1 h / 20 °C
3: Benzoylformic acid / Petroleum ether / 48 h / 20 °C / Irradiation; Green chemistry
4: hydroxylamine hydrochloride; triethylamine / dichloromethane / 24 h / 20 °C
View Scheme
With hydroxylamine hydrochloride In tetrahydrofuran; methanol at 20℃; for 1.5h;
With hydroxylamine hydrochloride; potassium hydroxide In tetrahydrofuran; methanol at 20℃; for 0.5h;0.14 g
suberic acid monomethyl ester
3946-32-5

suberic acid monomethyl ester

vorinostat
149647-78-9

vorinostat

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 88.7 percent / 1-hydroxybenzotriazole; dicyclohexylcarbodiimide / dimethylformamide / 1.5 h / 20 °C
2: 90 percent / hydroxylamine; KOH / methanol / 1 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 3 h / Reflux
2: triethylamine / dichloromethane / 1.5 h / 20 °C
3: hydroxylamine hydrochloride; sodium methylate / methanol / 0.67 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: 1-hydroxy-1H-benzotriazole hydrate / N,N-dimethyl-formamide
2: potassium hydroxide; hydroxylamine hydrochloride / methanol
View Scheme
Multi-step reaction with 4 steps
1.1: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dichloromethane / 20 °C / Cooling with ice
2.1: lithium hydroxide; water / tetrahydrofuran / 12 h / 20 °C
3.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 °C / Cooling with ice
3.2: 20 °C
4.1: dihydrogen peroxide / aq. phosphate buffer / 4 h / 37 °C / pH 7.4
View Scheme
aniline
62-53-3

aniline

[(Xantphos)2Pd(3-methyl-1-butenyl]OTf

[(Xantphos)2Pd(3-methyl-1-butenyl]OTf

vorinostat
149647-78-9

vorinostat

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 88.7 percent / 1-hydroxybenzotriazole; dicyclohexylcarbodiimide / dimethylformamide / 1.5 h / 20 °C
2: 90 percent / hydroxylamine; KOH / methanol / 1 h / 20 °C
View Scheme
octane-1,8-dioic acid
505-48-6

octane-1,8-dioic acid

vorinostat
149647-78-9

vorinostat

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 96 percent / Ac2O / 1 h / Heating
2: 94 percent / tetrahydrofuran / 0.5 h / 20 °C
3: Et3N / tetrahydrofuran / 0.17 h
4: NH2OH / methanol
View Scheme
Multi-step reaction with 6 steps
1.1: 0.17 h / 150 - 180 °C
1.2: 0.33 h / 20 °C
2.1: triethylamine / tetrahydrofuran / 0.25 h / -10 °C
3.1: sodium tetrahydroborate / methanol / 0.5 h / 0 °C
4.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C
5.1: Benzoylformic acid / Petroleum ether / 48 h / 20 °C / Irradiation; Green chemistry
6.1: hydroxylamine hydrochloride; triethylamine / dichloromethane / 24 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: 0.17 h / 185 - 190 °C / Sealed tube
2: Dowex50W-X2 acid resin / 22 h / Reflux
3: methanol; hydroxylamine hydrochloride; sodium
View Scheme
Multi-step reaction with 3 steps
1.1: 0.33 h / 175 - 190 °C
1.2: 0.33 h
2.1: 18 h / Heating / reflux
3.1: hydroxylamine hydrochloride; sodium methylate / methanol
View Scheme
Multi-step reaction with 3 steps
1.1: acetic anhydride
2.1: tetrahydrofuran
3.1: triethylamine; chloroformic acid ethyl ester / 0 °C
3.2: 20 °C
View Scheme
oxonane-2,9-dione
10521-06-9

oxonane-2,9-dione

vorinostat
149647-78-9

vorinostat

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 94 percent / tetrahydrofuran / 0.5 h / 20 °C
2: Et3N / tetrahydrofuran / 0.17 h
3: NH2OH / methanol
View Scheme
Multi-step reaction with 3 steps
1: copper(l) iodide / 1,4-dioxane; water
2: zinc(II) chloride / 3 h / 50 °C
3: sodium methylate; hydroxylamine hydrochloride / methanol / 3 h / 40 °C
View Scheme
Multi-step reaction with 2 steps
1.1: tetrahydrofuran
2.1: triethylamine; chloroformic acid ethyl ester / 0 °C
2.2: 20 °C
View Scheme
C16H21NO5

C16H21NO5

vorinostat
149647-78-9

vorinostat

Conditions
ConditionsYield
With hydroxylamine In tetrahydrofuran; methanol at 0 - 5℃; for 0.25h;
octane-1,8-dioic acid
505-48-6

octane-1,8-dioic acid

aniline
62-53-3

aniline

vorinostat
149647-78-9

vorinostat

Conditions
ConditionsYield
With hydroxylamine; dicyclohexyl-carbodiimide; 1,1'-carbonyldiimidazole In tetrahydrofuran at 25 - 30℃;
Multi-step reaction with 2 steps
1.1: dicyclohexyl-carbodiimide; 1,1'-carbonyldiimidazole / tetrahydrofuran
2.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 0.5 h / 25 - 30 °C
2.2: 0.5 h
View Scheme
Multi-step reaction with 2 steps
1.1: N-ethyl-N,N-diisopropylamine; ethyl 2-(tert-butoxycarbonyloxyimino)-2-cyanoacetate / tetrahydrofuran / 1 h / 0 - 5 °C
2.1: dmap; N-ethyl-N,N-diisopropylamine; ethyl 2-(tert-butoxycarbonyloxyimino)-2-cyanoacetate / tetrahydrofuran / 0.5 h / 0 - 5 °C
2.2: 20 °C
View Scheme
suberic acid monomethyl ester
3946-32-5

suberic acid monomethyl ester

aniline
62-53-3

aniline

vorinostat
149647-78-9

vorinostat

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.08 h
1.2: 4 h / 25 °C
2.1: hydroxylamine hydrochloride; potassium hydroxide / methanol / 0.1 h / 80 °C / Microwave irradiation
View Scheme
Multi-step reaction with 2 steps
1: boric acid / toluene / 10 h / Reflux; Dean-Stark; Inert atmosphere; Green chemistry
2: potassium hydroxide; hydroxylamine hydrochloride / methanol / 0.5 h / 20 - 40 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C
2: hydroxylamine; potassium hydroxide / methanol / 1.5 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: boric acid / toluene / 10 h / Reflux; Inert atmosphere; Dean-Stark; Green chemistry
2: potassium hydroxide; hydroxylamine hydrochloride / methanol / 1 h / 40 °C / Green chemistry
View Scheme
8-oxo-N-phenyloctanamide

8-oxo-N-phenyloctanamide

vorinostat
149647-78-9

vorinostat

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Benzoylformic acid / Petroleum ether / 48 h / 20 °C / Irradiation; Green chemistry
2: hydroxylamine hydrochloride; triethylamine / dichloromethane / 24 h / 20 °C
View Scheme
8-hydroxy-N-phenyloctanamide

8-hydroxy-N-phenyloctanamide

vorinostat
149647-78-9

vorinostat

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C
2: Benzoylformic acid / Petroleum ether / 48 h / 20 °C / Irradiation; Green chemistry
3: hydroxylamine hydrochloride; triethylamine / dichloromethane / 24 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydroxide; potassium permanganate / water / 20 °C
2.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 0.5 h / 0 °C
2.2: 1 h / 20 °C
View Scheme
aniline
62-53-3

aniline

vorinostat
149647-78-9

vorinostat

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: 0.17 h / 150 - 180 °C
1.2: 0.33 h / 20 °C
2.1: triethylamine / tetrahydrofuran / 0.25 h / -10 °C
3.1: sodium tetrahydroborate / methanol / 0.5 h / 0 °C
4.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C
5.1: Benzoylformic acid / Petroleum ether / 48 h / 20 °C / Irradiation; Green chemistry
6.1: hydroxylamine hydrochloride; triethylamine / dichloromethane / 24 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: copper(l) iodide / 1,4-dioxane; water
2: zinc(II) chloride / 3 h / 50 °C
3: sodium methylate; hydroxylamine hydrochloride / methanol / 3 h / 40 °C
View Scheme
Multi-step reaction with 3 steps
1.1: 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine / 24 h / 100 °C
2.1: sodium hydroxide; potassium permanganate / water / 20 °C
3.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 0.5 h / 0 °C
3.2: 1 h / 20 °C
View Scheme
diisopropyl 1-(8-oxo-8-(phenylamino)octanoyl)hydrazine-1,2-dicarboxylate

diisopropyl 1-(8-oxo-8-(phenylamino)octanoyl)hydrazine-1,2-dicarboxylate

vorinostat
149647-78-9

vorinostat

Conditions
ConditionsYield
With hydroxylamine hydrochloride; triethylamine In dichloromethane at 20℃; for 24h;
oxonan-2-one
5698-29-3

oxonan-2-one

vorinostat
149647-78-9

vorinostat

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine / 24 h / 100 °C
2.1: sodium hydroxide; potassium permanganate / water / 20 °C
3.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 0.5 h / 0 °C
3.2: 1 h / 20 °C
View Scheme
(4-(((8-oxo-8-(phenylamino)octanamido)oxy)methyl)phenyl)boronic acid

(4-(((8-oxo-8-(phenylamino)octanamido)oxy)methyl)phenyl)boronic acid

vorinostat
149647-78-9

vorinostat

Conditions
ConditionsYield
With dihydrogen peroxide In aq. phosphate buffer at 37℃; for 4h; pH=7.4; Reagent/catalyst;
(4-(((8-oxo-8-(phenylamino)octanamido)oxy)methyl)phenyl)boronic acid

(4-(((8-oxo-8-(phenylamino)octanamido)oxy)methyl)phenyl)boronic acid

A

C21H26N2O4

C21H26N2O4

B

vorinostat
149647-78-9

vorinostat

Conditions
ConditionsYield
With dihydrogen peroxide In aq. phosphate buffer at 37℃; for 4h; pH=7.4; Reagent/catalyst;
aniline
62-53-3

aniline

A

C21H26N2O4

C21H26N2O4

B

vorinostat
149647-78-9

vorinostat

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dichloromethane / 20 °C / Cooling with ice
2.1: lithium hydroxide; water / tetrahydrofuran / 12 h / 20 °C
3.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 °C / Cooling with ice
3.2: 20 °C
4.1: dihydrogen peroxide / aq. phosphate buffer / 4 h / 37 °C / pH 7.4
View Scheme
suberic acid monomethyl ester
3946-32-5

suberic acid monomethyl ester

A

C21H26N2O4

C21H26N2O4

B

vorinostat
149647-78-9

vorinostat

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dichloromethane / 20 °C / Cooling with ice
2.1: lithium hydroxide; water / tetrahydrofuran / 12 h / 20 °C
3.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 °C / Cooling with ice
3.2: 20 °C
4.1: dihydrogen peroxide / aq. phosphate buffer / 4 h / 37 °C / pH 7.4
View Scheme
7-phenylcarbamoyl heptanoic acid methyl ester
162853-41-0

7-phenylcarbamoyl heptanoic acid methyl ester

A

C21H26N2O4

C21H26N2O4

B

vorinostat
149647-78-9

vorinostat

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: lithium hydroxide; water / tetrahydrofuran / 12 h / 20 °C
2.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 °C / Cooling with ice
2.2: 20 °C
3.1: dihydrogen peroxide / aq. phosphate buffer / 4 h / 37 °C / pH 7.4
View Scheme
suberanilic acid
149648-52-2

suberanilic acid

A

C21H26N2O4

C21H26N2O4

B

vorinostat
149647-78-9

vorinostat

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 °C / Cooling with ice
1.2: 20 °C
2.1: dihydrogen peroxide / aq. phosphate buffer / 4 h / 37 °C / pH 7.4
View Scheme
N-phenylhept-6-enamide

N-phenylhept-6-enamide

vorinostat
149647-78-9

vorinostat

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 3 h / Reflux; Inert atmosphere
2: 10 wt% Pd(OH)2 on carbon; trifluoroacetic acid; hydrogen / methanol / 2 h / 20 °C
View Scheme
(E)-methyl 8-(benzyloxyamino)-8-oxooct-6-enoate

(E)-methyl 8-(benzyloxyamino)-8-oxooct-6-enoate

vorinostat
149647-78-9

vorinostat

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 4 h / 20 °C
2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.25 h / 0 °C
2.2: 16 h / 0 - 20 °C
3.1: 10 wt% Pd(OH)2 on carbon; trifluoroacetic acid; hydrogen / methanol / 2 h / 20 °C
View Scheme
methyl hept-6-enoate
1745-17-1

methyl hept-6-enoate

vorinostat
149647-78-9

vorinostat

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 3 h / Reflux; Inert atmosphere
2.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 4 h / 20 °C
3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.25 h / 0 °C
3.2: 16 h / 0 - 20 °C
4.1: 10 wt% Pd(OH)2 on carbon; trifluoroacetic acid; hydrogen / methanol / 2 h / 20 °C
View Scheme
C15H19NO4

C15H19NO4

vorinostat
149647-78-9

vorinostat

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.25 h / 0 °C
1.2: 16 h / 0 - 20 °C
2.1: 10 wt% Pd(OH)2 on carbon; trifluoroacetic acid; hydrogen / methanol / 2 h / 20 °C
View Scheme
vorinostat
149647-78-9

vorinostat

suberoylanilide hydroxamic acid iron complex

suberoylanilide hydroxamic acid iron complex

Conditions
ConditionsYield
With iron(III) chloride; N-ethyl-N,N-diisopropylamine In ethanol at 20℃; for 16.0833h;96%
phenyl isocyanate
103-71-9

phenyl isocyanate

vorinostat
149647-78-9

vorinostat

[(8-anilino-8-oxo-octanoyl)amino] N-phenylcarbamate

[(8-anilino-8-oxo-octanoyl)amino] N-phenylcarbamate

Conditions
ConditionsYield
In N,N-dimethyl-formamide; acetone at -15 - 20℃;96%
benzyl isothiocyanate
3173-56-6

benzyl isothiocyanate

vorinostat
149647-78-9

vorinostat

[(8-anilino-8-oxo-octanoyl)amino] N-benzylcarbamate

[(8-anilino-8-oxo-octanoyl)amino] N-benzylcarbamate

Conditions
ConditionsYield
In N,N-dimethyl-formamide; acetone at -15 - 20℃;94%
vorinostat
149647-78-9

vorinostat

Isopropyl isocyanate
1795-48-8

Isopropyl isocyanate

[(8-anilino-8-oxo-octanoyl)amino] N-isopropylcarbamate

[(8-anilino-8-oxo-octanoyl)amino] N-isopropylcarbamate

Conditions
ConditionsYield
In N,N-dimethyl-formamide; acetone at -15 - 20℃;93%
vorinostat
149647-78-9

vorinostat

ethyl isocyanate
109-90-0

ethyl isocyanate

[(8-anilino-8-oxo-octanoyl)amino] N-ethylcarbamate

[(8-anilino-8-oxo-octanoyl)amino] N-ethylcarbamate

Conditions
ConditionsYield
In N,N-dimethyl-formamide; acetone at -15 - 20℃;92%
C44H74ClN3O11Si3

C44H74ClN3O11Si3

vorinostat
149647-78-9

vorinostat

C58H93N5O14Si3

C58H93N5O14Si3

Conditions
ConditionsYield
With pyridine at 0 - 25℃; for 5h;92%
vorinostat
149647-78-9

vorinostat

N,N'-dimethyl-N-benzyl-[4-(2,3,4-tri-O-tert-butyldimethylsilyl-β-D-glucopyranosyl)uronate-3-nitrobenzoyloxycarbonyl]ethylenediamine carbamoyl chloride
637330-41-7

N,N'-dimethyl-N-benzyl-[4-(2,3,4-tri-O-tert-butyldimethylsilyl-β-D-glucopyranosyl)uronate-3-nitrobenzoyloxycarbonyl]ethylenediamine carbamoyl chloride

C58H91N5O15Si3

C58H91N5O15Si3

Conditions
ConditionsYield
In pyridine at 0 - 25℃; for 5h;92%
With pyridine at 0 - 20℃; for 5h;85%
2,3,4,6-tetra-O-acetyl-D-glucopyranosyl 1-(N-phenyl)-2,2,2-trifluoroacetimidate
942428-83-3

2,3,4,6-tetra-O-acetyl-D-glucopyranosyl 1-(N-phenyl)-2,2,2-trifluoroacetimidate

vorinostat
149647-78-9

vorinostat

2,3,4,6-tetra-O-acetyl-1-O-7-(phenylcarbamoyl)hepthydroxamoyl-β-D-glucopyranose

2,3,4,6-tetra-O-acetyl-1-O-7-(phenylcarbamoyl)hepthydroxamoyl-β-D-glucopyranose

Conditions
ConditionsYield
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at -20 - 20℃;90%
2,3,4,6-tetra-O-acetyl-D-mannopyranosyl 1-(N-phenyl)-2,2,2-trifluoroacetimidate
942428-90-2

2,3,4,6-tetra-O-acetyl-D-mannopyranosyl 1-(N-phenyl)-2,2,2-trifluoroacetimidate

vorinostat
149647-78-9

vorinostat

2,3,4,6-tetra-O-acetyl-1-O-7-(phenylcarbamoyl)hepthydroxamoyl-α-D-mannopyranose

2,3,4,6-tetra-O-acetyl-1-O-7-(phenylcarbamoyl)hepthydroxamoyl-α-D-mannopyranose

Conditions
ConditionsYield
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at -20 - 20℃;84%
4-bromomethyl-3-nitrobenzoic acid
55715-03-2

4-bromomethyl-3-nitrobenzoic acid

vorinostat
149647-78-9

vorinostat

C22H25N3O7

C22H25N3O7

Conditions
ConditionsYield
With sodium hydroxide In methanol at 20℃; for 18h;83%
N1,N2-dimethyl-N1-(2-phenylcyclopropyl)ethane-1,2-diamine dihydrochloride

N1,N2-dimethyl-N1-(2-phenylcyclopropyl)ethane-1,2-diamine dihydrochloride

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

vorinostat
149647-78-9

vorinostat

N1-((methyl(2-(methyl(2-phenylcyclopropyl)amino)ethyl)carbamoyl)oxy)-N8-phenyloctanediamide

N1-((methyl(2-(methyl(2-phenylcyclopropyl)amino)ethyl)carbamoyl)oxy)-N8-phenyloctanediamide

Conditions
ConditionsYield
Stage #1: 1,1'-carbonyldiimidazole; vorinostat In acetonitrile at 10℃; for 0.333333h;
Stage #2: N1,N2-dimethyl-N1-(2-phenylcyclopropyl)ethane-1,2-diamine dihydrochloride With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 12h;
82.7%
4-bromomethylbenzoic Acid
6232-88-8

4-bromomethylbenzoic Acid

vorinostat
149647-78-9

vorinostat

C22H26N2O5

C22H26N2O5

Conditions
ConditionsYield
With sodium hydroxide In methanol at 20℃; for 18h;79%
vorinostat
149647-78-9

vorinostat

N-[(8-anilino-8-oxooctanoyl)oxy]-N'-phenyloctanediamide

N-[(8-anilino-8-oxooctanoyl)oxy]-N'-phenyloctanediamide

Conditions
ConditionsYield
Stage #1: suberanilic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In DMF (N,N-dimethyl-formamide) for 0.0833333h;
Stage #2: vorinostat In DMF (N,N-dimethyl-formamide) for 24h;
77%
O-(methyl 2,3,4-tri-O-acetyl-D-glucuronopyranosyl)-N-phenyl-2,2,2-trifluoroacetimidate
869996-05-4

O-(methyl 2,3,4-tri-O-acetyl-D-glucuronopyranosyl)-N-phenyl-2,2,2-trifluoroacetimidate

vorinostat
149647-78-9

vorinostat

methyl 2,3,4-tri-O-acetyl-1-O-7-(phenylcarbamoyl)hepthydroxamoyl-β-D-glucopyranosyluronate
931415-42-8

methyl 2,3,4-tri-O-acetyl-1-O-7-(phenylcarbamoyl)hepthydroxamoyl-β-D-glucopyranosyluronate

Conditions
ConditionsYield
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at -20 - 20℃;76%
2-(bromomethyl)-3,5,6-trimethylcyclohexa-2,5-diene-1,4-dione

2-(bromomethyl)-3,5,6-trimethylcyclohexa-2,5-diene-1,4-dione

vorinostat
149647-78-9

vorinostat

N1-phenyl-N8-((2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)methoxy)octanediamide

N1-phenyl-N8-((2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)methoxy)octanediamide

Conditions
ConditionsYield
With sodium hydroxide In methanol at 20℃; for 18h; Inert atmosphere;74%
vorinostat
149647-78-9

vorinostat

benzylamine
100-46-9

benzylamine

C21H27N3O2
1200803-45-7

C21H27N3O2

Conditions
ConditionsYield
Stage #1: vorinostat With 4-methyl-morpholine; 1,3,5-trichloro-2,4,6-triazine In dichloroethane at 0℃; for 1.5h; Lossen rearrangement; Inert atmosphere;
Stage #2: benzylamine In dichloroethane at 0 - 84℃; for 15h; Lossen rearrangement; Inert atmosphere;
73%
2,3,5-tri-O-acetyl-D-ribofuranosyl 1-(N-phenyl)-2,2,2-trifluoroacetimidate
942428-91-3

2,3,5-tri-O-acetyl-D-ribofuranosyl 1-(N-phenyl)-2,2,2-trifluoroacetimidate

vorinostat
149647-78-9

vorinostat

2,3,5-tri-O-acetyl-1-O-7-(phenylcarbamoyl)hepthydroxamoyl-β-D-ribofuranose

2,3,5-tri-O-acetyl-1-O-7-(phenylcarbamoyl)hepthydroxamoyl-β-D-ribofuranose

Conditions
ConditionsYield
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at -20 - 20℃;69%
2,3,4,6-tetra-O-acetyl-D-galactosyl 1-(N-phenyl)-2,2,2-trifluoroacetimidate
942428-89-9

2,3,4,6-tetra-O-acetyl-D-galactosyl 1-(N-phenyl)-2,2,2-trifluoroacetimidate

vorinostat
149647-78-9

vorinostat

2,3,4,6-tetra-O-acetyl-1-O-7-(phenylcarbamoyl)hepthydroxamoyl-β-D-galactopyranose
931415-43-9

2,3,4,6-tetra-O-acetyl-1-O-7-(phenylcarbamoyl)hepthydroxamoyl-β-D-galactopyranose

Conditions
ConditionsYield
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at -20 - 20℃;69%
mono-4-vinylbenzyl succinate
139486-67-2

mono-4-vinylbenzyl succinate

vorinostat
149647-78-9

vorinostat

C27H32N2O6

C27H32N2O6

Conditions
ConditionsYield
Stage #1: mono-4-vinylbenzyl succinate With 1,1'-carbonyldiimidazole In dichloromethane for 0.166667h;
Stage #2: vorinostat for 2h; Reagent/catalyst;
69%
ethyl 7-(((S)-1-(((S)-1-((4-(bromomethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)amino)-7-oxoheptanoate

ethyl 7-(((S)-1-(((S)-1-((4-(bromomethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)amino)-7-oxoheptanoate

vorinostat
149647-78-9

vorinostat

ethyl 7-(((S)-3-methyl-1-oxo-1-(((S)-1-oxo-1-((4-(((8-oxo-8-(phenylamino)octanamido)oxy)methyl)phenyl)amino)-5-ureidopentan-2-yl)amino)butan-2-yl)amino)-7-oxoheptanoate

ethyl 7-(((S)-3-methyl-1-oxo-1-(((S)-1-oxo-1-((4-(((8-oxo-8-(phenylamino)octanamido)oxy)methyl)phenyl)amino)-5-ureidopentan-2-yl)amino)butan-2-yl)amino)-7-oxoheptanoate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 12h; Inert atmosphere;68%
[2,2]bipyridinyl
366-18-7

[2,2]bipyridinyl

copper(II) perchlorate hexahydrate

copper(II) perchlorate hexahydrate

vorinostat
149647-78-9

vorinostat

C24H27CuN4O3(1+)*ClO4(1-)

C24H27CuN4O3(1+)*ClO4(1-)

Conditions
ConditionsYield
With potassium hydroxide In methanol; water at 25℃; for 0.5h;67.7%
copper(II) perchlorate hexahydrate

copper(II) perchlorate hexahydrate

1,10-phenanthroline-5,6-dione
27318-90-7

1,10-phenanthroline-5,6-dione

vorinostat
149647-78-9

vorinostat

Cu-SAHA-Phendio

Cu-SAHA-Phendio

Conditions
ConditionsYield
With potassium hydroxide In methanol; ethanol; water at 25℃; for 0.5h;67%
6-(3-((4-(bromomethyl)phenyl)thio)-2,5-dioxopyrrolidin-1-yl)-N-(prop-2-yn-1-yl)hexanamide

6-(3-((4-(bromomethyl)phenyl)thio)-2,5-dioxopyrrolidin-1-yl)-N-(prop-2-yn-1-yl)hexanamide

vorinostat
149647-78-9

vorinostat

N1-((4-((2,5-dioxo-1-(6-oxo-6-(prop-2-yn-1-ylamino)hexyl)pyrrolidin-3-yl)thio)benzyl)oxy)-N8-phenyloctanediamide

N1-((4-((2,5-dioxo-1-(6-oxo-6-(prop-2-yn-1-ylamino)hexyl)pyrrolidin-3-yl)thio)benzyl)oxy)-N8-phenyloctanediamide

Conditions
ConditionsYield
Stage #1: vorinostat With sodium hydroxide In methanol; water
Stage #2: 6-(3-((4-(bromomethyl)phenyl)thio)-2,5-dioxopyrrolidin-1-yl)-N-(prop-2-yn-1-yl)hexanamide In methanol; water
67%
With sodium hydroxide In methanol Inert atmosphere;40%

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