Shandong Kehui Pharmaceutical Co., Ltd. is a modern high-tech pharmaceutical company that strictly complies with GMP requirements and produces high standards. The company was established in May 2017 and is located in the Yellow River Delta Medicine V
Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryUnique advantages for Vorinostat Cas 149647-78-9 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White or almost white powder Storage:-20°C Freezer Package:10g,100g,1kg/foil
Cas:149647-78-9
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
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TIANFUCHEM--149647-78-9--High purity Vorinostat in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business re
Cas:149647-78-9
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiryName: Vorinostat Synonyms: Octanediamide, N-hydroxy-N'-phenyl- CAS:149647-78-9 MF: C14H20N2O3 Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:25kg/drum Application: Pharmaceutical Intermediate T
We are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED
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inquiryAppearance:White or off white powder Storage:R.T Package:1kg/Bag Application:A deacetylase inhibitor Transportation:Express/Sea/Air Port:Any port in China
Cas:149647-78-9
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inquiry1.Prompt Goods; 2.Flexible payment terms; 3.Documents & Certificate support. Name: Vorinostat Molecular Structure: Formula: C14H20N2O3 Molecular Weight : 264.32 Synonyms: CS-1949;SAHAcpd;UNII-58IFB293JI;Vornostat;Octanediamide,N1-hydroxy-
Cas:149647-78-9
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
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inquiryProduct Name: Vorinostat Synonyms: CS-1949;SAHA cpd;UNII-58IFB293JI;Vornostat;Octanediamide, N1-hydroxy-N8-phenyl-;SAHA=N-Hydroxy-N'-phenyloctanediamide;SAHA, N-Hydroxy-Nphenyloctanediamide, Zolinza;Zolinza (See Suberoylanilide Hydroxamic A
Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Vorinostat CAS:149647-78-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
API name: Vorinostat Certificates: GMP, DMF CAS No.: 149647-78-9 Chemical name: SAHA M344 Vorinostat/SAHA Vorinostat Zolinza Formula: C14H20N2O3 Structure: Appearance:White or off white powder Storage:Store sealed at room
1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s
Cas:149647-78-9
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inquiryQ1: Are you a manufacturer?Answer: Yes, we are factory founded on 2002. Q2: How to contact with us?Click "contact supplier" And then send us message the product you interest in, you will get reply within 12 hours. Q3:Which kind of payment terms do yo
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
7-phenylcarbamoyl heptanoic acid methyl ester
vorinostat
Conditions | Yield |
---|---|
Stage #1: 7-phenylcarbamoyl heptanoic acid methyl ester With hydroxylamine hydrochloride; sodium methylate In methanol; water for 16.1667h; Stage #2: With water; acetic acid In methanol for 0.166667h; pH=8.7 - 12.02; | 95.6% |
With hydroxylamine hydrochloride; sodium methylate In methanol for 16.1667h; | 95.6% |
Stage #1: 7-phenylcarbamoyl heptanoic acid methyl ester With hydroxylamine hydrochloride; sodium methylate In methanol for 16.3333h; Stage #2: With sodium methylate In methanol; water for 0.166667h; pH=12.01 - 12.02; Stage #3: With acetic acid In methanol; water pH=8.70 - 8.98; Product distribution / selectivity; | 95.6% |
vorinostat
Conditions | Yield |
---|---|
With 10 wt% Pd(OH)2 on carbon; hydrogen; trifluoroacetic acid In methanol at 20℃; for 2h; | 91% |
N-phenylhexanamide
vorinostat
Conditions | Yield |
---|---|
With hydroxylamine hydrochloride In N,N-dimethyl-formamide at 40℃; for 1h; Reagent/catalyst; | 88.5% |
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide; potassium hydroxide In ethanol at 50℃; for 0.5h; | 82.4% |
With dicyclohexyl-carbodiimide; 1,1'-carbonyldiimidazole In tetrahydrofuran |
suberanilic acid
vorinostat
Conditions | Yield |
---|---|
With C36H24B4N2O3; hydroxylamine hydrochloride; triethylamine In toluene at 80℃; for 14h; Molecular sieve; | 82% |
Stage #1: suberanilic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 25 - 30℃; for 0.5h; Stage #2: With hydroxylamine hydrochloride In N,N-dimethyl-formamide for 0.5h; | 75% |
Stage #1: suberanilic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 25 - 30℃; for 0.5h; Stage #2: With hydroxylamine hydrochloride In N,N-dimethyl-formamide for 0.5h; | 75% |
7-phenylcarbamoyl heptanoic acid methyl ester
A
suberanilic acid
B
vorinostat
Conditions | Yield |
---|---|
With water; hydroxylamine; sodium methylate In methanol at 90℃; | A 15% B 80% |
vorinostat
Conditions | Yield |
---|---|
With hydroxylamine In methanol | |
With hydroxylamine hydrochloride; potassium hydroxide In methanol at 20℃; for 0.25h; | |
Multi-step reaction with 4 steps 1: sodium tetrahydroborate / methanol / 0.5 h / 0 °C 2: Dess-Martin periodane / dichloromethane / 1 h / 20 °C 3: Benzoylformic acid / Petroleum ether / 48 h / 20 °C / Irradiation; Green chemistry 4: hydroxylamine hydrochloride; triethylamine / dichloromethane / 24 h / 20 °C View Scheme | |
With hydroxylamine hydrochloride In tetrahydrofuran; methanol at 20℃; for 1.5h; | |
With hydroxylamine hydrochloride; potassium hydroxide In tetrahydrofuran; methanol at 20℃; for 0.5h; | 0.14 g |
suberic acid monomethyl ester
vorinostat
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 88.7 percent / 1-hydroxybenzotriazole; dicyclohexylcarbodiimide / dimethylformamide / 1.5 h / 20 °C 2: 90 percent / hydroxylamine; KOH / methanol / 1 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 3 h / Reflux 2: triethylamine / dichloromethane / 1.5 h / 20 °C 3: hydroxylamine hydrochloride; sodium methylate / methanol / 0.67 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: 1-hydroxy-1H-benzotriazole hydrate / N,N-dimethyl-formamide 2: potassium hydroxide; hydroxylamine hydrochloride / methanol View Scheme | |
Multi-step reaction with 4 steps 1.1: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dichloromethane / 20 °C / Cooling with ice 2.1: lithium hydroxide; water / tetrahydrofuran / 12 h / 20 °C 3.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 °C / Cooling with ice 3.2: 20 °C 4.1: dihydrogen peroxide / aq. phosphate buffer / 4 h / 37 °C / pH 7.4 View Scheme |
aniline
vorinostat
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 88.7 percent / 1-hydroxybenzotriazole; dicyclohexylcarbodiimide / dimethylformamide / 1.5 h / 20 °C 2: 90 percent / hydroxylamine; KOH / methanol / 1 h / 20 °C View Scheme |
octane-1,8-dioic acid
vorinostat
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 96 percent / Ac2O / 1 h / Heating 2: 94 percent / tetrahydrofuran / 0.5 h / 20 °C 3: Et3N / tetrahydrofuran / 0.17 h 4: NH2OH / methanol View Scheme | |
Multi-step reaction with 6 steps 1.1: 0.17 h / 150 - 180 °C 1.2: 0.33 h / 20 °C 2.1: triethylamine / tetrahydrofuran / 0.25 h / -10 °C 3.1: sodium tetrahydroborate / methanol / 0.5 h / 0 °C 4.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C 5.1: Benzoylformic acid / Petroleum ether / 48 h / 20 °C / Irradiation; Green chemistry 6.1: hydroxylamine hydrochloride; triethylamine / dichloromethane / 24 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: 0.17 h / 185 - 190 °C / Sealed tube 2: Dowex50W-X2 acid resin / 22 h / Reflux 3: methanol; hydroxylamine hydrochloride; sodium View Scheme | |
Multi-step reaction with 3 steps 1.1: 0.33 h / 175 - 190 °C 1.2: 0.33 h 2.1: 18 h / Heating / reflux 3.1: hydroxylamine hydrochloride; sodium methylate / methanol View Scheme | |
Multi-step reaction with 3 steps 1.1: acetic anhydride 2.1: tetrahydrofuran 3.1: triethylamine; chloroformic acid ethyl ester / 0 °C 3.2: 20 °C View Scheme |
oxonane-2,9-dione
vorinostat
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 94 percent / tetrahydrofuran / 0.5 h / 20 °C 2: Et3N / tetrahydrofuran / 0.17 h 3: NH2OH / methanol View Scheme | |
Multi-step reaction with 3 steps 1: copper(l) iodide / 1,4-dioxane; water 2: zinc(II) chloride / 3 h / 50 °C 3: sodium methylate; hydroxylamine hydrochloride / methanol / 3 h / 40 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: tetrahydrofuran 2.1: triethylamine; chloroformic acid ethyl ester / 0 °C 2.2: 20 °C View Scheme |
vorinostat
Conditions | Yield |
---|---|
With hydroxylamine In tetrahydrofuran; methanol at 0 - 5℃; for 0.25h; |
Conditions | Yield |
---|---|
With hydroxylamine; dicyclohexyl-carbodiimide; 1,1'-carbonyldiimidazole In tetrahydrofuran at 25 - 30℃; | |
Multi-step reaction with 2 steps 1.1: dicyclohexyl-carbodiimide; 1,1'-carbonyldiimidazole / tetrahydrofuran 2.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 0.5 h / 25 - 30 °C 2.2: 0.5 h View Scheme | |
Multi-step reaction with 2 steps 1.1: N-ethyl-N,N-diisopropylamine; ethyl 2-(tert-butoxycarbonyloxyimino)-2-cyanoacetate / tetrahydrofuran / 1 h / 0 - 5 °C 2.1: dmap; N-ethyl-N,N-diisopropylamine; ethyl 2-(tert-butoxycarbonyloxyimino)-2-cyanoacetate / tetrahydrofuran / 0.5 h / 0 - 5 °C 2.2: 20 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.08 h 1.2: 4 h / 25 °C 2.1: hydroxylamine hydrochloride; potassium hydroxide / methanol / 0.1 h / 80 °C / Microwave irradiation View Scheme | |
Multi-step reaction with 2 steps 1: boric acid / toluene / 10 h / Reflux; Dean-Stark; Inert atmosphere; Green chemistry 2: potassium hydroxide; hydroxylamine hydrochloride / methanol / 0.5 h / 20 - 40 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C 2: hydroxylamine; potassium hydroxide / methanol / 1.5 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: boric acid / toluene / 10 h / Reflux; Inert atmosphere; Dean-Stark; Green chemistry 2: potassium hydroxide; hydroxylamine hydrochloride / methanol / 1 h / 40 °C / Green chemistry View Scheme |
vorinostat
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Benzoylformic acid / Petroleum ether / 48 h / 20 °C / Irradiation; Green chemistry 2: hydroxylamine hydrochloride; triethylamine / dichloromethane / 24 h / 20 °C View Scheme |
vorinostat
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C 2: Benzoylformic acid / Petroleum ether / 48 h / 20 °C / Irradiation; Green chemistry 3: hydroxylamine hydrochloride; triethylamine / dichloromethane / 24 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: sodium hydroxide; potassium permanganate / water / 20 °C 2.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 0.5 h / 0 °C 2.2: 1 h / 20 °C View Scheme |
aniline
vorinostat
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: 0.17 h / 150 - 180 °C 1.2: 0.33 h / 20 °C 2.1: triethylamine / tetrahydrofuran / 0.25 h / -10 °C 3.1: sodium tetrahydroborate / methanol / 0.5 h / 0 °C 4.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C 5.1: Benzoylformic acid / Petroleum ether / 48 h / 20 °C / Irradiation; Green chemistry 6.1: hydroxylamine hydrochloride; triethylamine / dichloromethane / 24 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: copper(l) iodide / 1,4-dioxane; water 2: zinc(II) chloride / 3 h / 50 °C 3: sodium methylate; hydroxylamine hydrochloride / methanol / 3 h / 40 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine / 24 h / 100 °C 2.1: sodium hydroxide; potassium permanganate / water / 20 °C 3.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 0.5 h / 0 °C 3.2: 1 h / 20 °C View Scheme |
vorinostat
Conditions | Yield |
---|---|
With hydroxylamine hydrochloride; triethylamine In dichloromethane at 20℃; for 24h; |
oxonan-2-one
vorinostat
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine / 24 h / 100 °C 2.1: sodium hydroxide; potassium permanganate / water / 20 °C 3.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 0.5 h / 0 °C 3.2: 1 h / 20 °C View Scheme |
vorinostat
Conditions | Yield |
---|---|
With dihydrogen peroxide In aq. phosphate buffer at 37℃; for 4h; pH=7.4; Reagent/catalyst; |
B
vorinostat
Conditions | Yield |
---|---|
With dihydrogen peroxide In aq. phosphate buffer at 37℃; for 4h; pH=7.4; Reagent/catalyst; |
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dichloromethane / 20 °C / Cooling with ice 2.1: lithium hydroxide; water / tetrahydrofuran / 12 h / 20 °C 3.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 °C / Cooling with ice 3.2: 20 °C 4.1: dihydrogen peroxide / aq. phosphate buffer / 4 h / 37 °C / pH 7.4 View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dichloromethane / 20 °C / Cooling with ice 2.1: lithium hydroxide; water / tetrahydrofuran / 12 h / 20 °C 3.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 °C / Cooling with ice 3.2: 20 °C 4.1: dihydrogen peroxide / aq. phosphate buffer / 4 h / 37 °C / pH 7.4 View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: lithium hydroxide; water / tetrahydrofuran / 12 h / 20 °C 2.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 °C / Cooling with ice 2.2: 20 °C 3.1: dihydrogen peroxide / aq. phosphate buffer / 4 h / 37 °C / pH 7.4 View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 °C / Cooling with ice 1.2: 20 °C 2.1: dihydrogen peroxide / aq. phosphate buffer / 4 h / 37 °C / pH 7.4 View Scheme |
vorinostat
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 3 h / Reflux; Inert atmosphere 2: 10 wt% Pd(OH)2 on carbon; trifluoroacetic acid; hydrogen / methanol / 2 h / 20 °C View Scheme |
vorinostat
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 4 h / 20 °C 2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.25 h / 0 °C 2.2: 16 h / 0 - 20 °C 3.1: 10 wt% Pd(OH)2 on carbon; trifluoroacetic acid; hydrogen / methanol / 2 h / 20 °C View Scheme |
methyl hept-6-enoate
vorinostat
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 3 h / Reflux; Inert atmosphere 2.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 4 h / 20 °C 3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.25 h / 0 °C 3.2: 16 h / 0 - 20 °C 4.1: 10 wt% Pd(OH)2 on carbon; trifluoroacetic acid; hydrogen / methanol / 2 h / 20 °C View Scheme |
vorinostat
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.25 h / 0 °C 1.2: 16 h / 0 - 20 °C 2.1: 10 wt% Pd(OH)2 on carbon; trifluoroacetic acid; hydrogen / methanol / 2 h / 20 °C View Scheme |
vorinostat
Conditions | Yield |
---|---|
With iron(III) chloride; N-ethyl-N,N-diisopropylamine In ethanol at 20℃; for 16.0833h; | 96% |
phenyl isocyanate
vorinostat
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide; acetone at -15 - 20℃; | 96% |
benzyl isothiocyanate
vorinostat
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide; acetone at -15 - 20℃; | 94% |
vorinostat
Isopropyl isocyanate
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide; acetone at -15 - 20℃; | 93% |
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide; acetone at -15 - 20℃; | 92% |
Conditions | Yield |
---|---|
With pyridine at 0 - 25℃; for 5h; | 92% |
vorinostat
N,N'-dimethyl-N-benzyl-[4-(2,3,4-tri-O-tert-butyldimethylsilyl-β-D-glucopyranosyl)uronate-3-nitrobenzoyloxycarbonyl]ethylenediamine carbamoyl chloride
Conditions | Yield |
---|---|
In pyridine at 0 - 25℃; for 5h; | 92% |
With pyridine at 0 - 20℃; for 5h; | 85% |
2,3,4,6-tetra-O-acetyl-D-glucopyranosyl 1-(N-phenyl)-2,2,2-trifluoroacetimidate
vorinostat
Conditions | Yield |
---|---|
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at -20 - 20℃; | 90% |
2,3,4,6-tetra-O-acetyl-D-mannopyranosyl 1-(N-phenyl)-2,2,2-trifluoroacetimidate
vorinostat
Conditions | Yield |
---|---|
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at -20 - 20℃; | 84% |
Conditions | Yield |
---|---|
With sodium hydroxide In methanol at 20℃; for 18h; | 83% |
1,1'-carbonyldiimidazole
vorinostat
Conditions | Yield |
---|---|
Stage #1: 1,1'-carbonyldiimidazole; vorinostat In acetonitrile at 10℃; for 0.333333h; Stage #2: N1,N2-dimethyl-N1-(2-phenylcyclopropyl)ethane-1,2-diamine dihydrochloride With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 12h; | 82.7% |
Conditions | Yield |
---|---|
With sodium hydroxide In methanol at 20℃; for 18h; | 79% |
vorinostat
Conditions | Yield |
---|---|
Stage #1: suberanilic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In DMF (N,N-dimethyl-formamide) for 0.0833333h; Stage #2: vorinostat In DMF (N,N-dimethyl-formamide) for 24h; | 77% |
O-(methyl 2,3,4-tri-O-acetyl-D-glucuronopyranosyl)-N-phenyl-2,2,2-trifluoroacetimidate
vorinostat
methyl 2,3,4-tri-O-acetyl-1-O-7-(phenylcarbamoyl)hepthydroxamoyl-β-D-glucopyranosyluronate
Conditions | Yield |
---|---|
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at -20 - 20℃; | 76% |
vorinostat
Conditions | Yield |
---|---|
With sodium hydroxide In methanol at 20℃; for 18h; Inert atmosphere; | 74% |
Conditions | Yield |
---|---|
Stage #1: vorinostat With 4-methyl-morpholine; 1,3,5-trichloro-2,4,6-triazine In dichloroethane at 0℃; for 1.5h; Lossen rearrangement; Inert atmosphere; Stage #2: benzylamine In dichloroethane at 0 - 84℃; for 15h; Lossen rearrangement; Inert atmosphere; | 73% |
2,3,5-tri-O-acetyl-D-ribofuranosyl 1-(N-phenyl)-2,2,2-trifluoroacetimidate
vorinostat
Conditions | Yield |
---|---|
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at -20 - 20℃; | 69% |
2,3,4,6-tetra-O-acetyl-D-galactosyl 1-(N-phenyl)-2,2,2-trifluoroacetimidate
vorinostat
2,3,4,6-tetra-O-acetyl-1-O-7-(phenylcarbamoyl)hepthydroxamoyl-β-D-galactopyranose
Conditions | Yield |
---|---|
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at -20 - 20℃; | 69% |
Conditions | Yield |
---|---|
Stage #1: mono-4-vinylbenzyl succinate With 1,1'-carbonyldiimidazole In dichloromethane for 0.166667h; Stage #2: vorinostat for 2h; Reagent/catalyst; | 69% |
vorinostat
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 12h; Inert atmosphere; | 68% |
[2,2]bipyridinyl
vorinostat
Conditions | Yield |
---|---|
With potassium hydroxide In methanol; water at 25℃; for 0.5h; | 67.7% |
1,10-phenanthroline-5,6-dione
vorinostat
Conditions | Yield |
---|---|
With potassium hydroxide In methanol; ethanol; water at 25℃; for 0.5h; | 67% |
vorinostat
Conditions | Yield |
---|---|
Stage #1: vorinostat With sodium hydroxide In methanol; water Stage #2: 6-(3-((4-(bromomethyl)phenyl)thio)-2,5-dioxopyrrolidin-1-yl)-N-(prop-2-yn-1-yl)hexanamide In methanol; water | 67% |
With sodium hydroxide In methanol Inert atmosphere; | 40% |
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