Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
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inquiry3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid CAS 176969-34-9 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/
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inquiryTianfu Chemical, built in 2009, is a professional supplier for API materials in China. With 10 years development, we have bulit our own factory and lab to produce a certain of products. And we have established stable business relationships with ma
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inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
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inquiryProduct Name: 3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid Density 1.52g/cm3 Boiling Point 315.9ºC at 760 mmHg Flash Point 144.9ºC Refractive Index 1.533 Vapor Pressur
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
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inquiry3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid CAS:176969-34-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, spe
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryAppearance:white powder/crystal Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/Ai
Cas:176969-34-9
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquirylow price high quality high purity good sevice stock Appearance:white Storage:Preserve In Well-Closed, Light-Resistant and Tight Containers. Store In Cool & Dry Place Package:1g,5g,10g...1kg,5kg...more Application:Pharmaceutical intermediat
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inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquiryHangzhou Verychem Science And Technology Co. Ltd. was set up in year 2004, it’s a young but fast growing company. In the twelve years history, it invested two pharmaceutical raw material production plants, one researching company, and several
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inquiryProduct name: 3-Difluoromethyl-1-Methyl-1H-Pyrazol-4-Carboxylicacid CAS No.: 176969-34-9 Molecule Formula:C6H6F2N2O2 Molecule Weight:176.12 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Sta
Cas:176969-34-9
Min.Order:1 Kilogram
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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inquiryOur Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
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inquiry3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
Conditions | Yield |
---|---|
With manganese(II) acetate dihydrate; acetic acid at 100℃; for 18h; Reagent/catalyst; | 100% |
With sodium hypochlorite; sodium hydroxide In water at 70℃; for 2h; Temperature; Reagent/catalyst; | 98% |
With sodium hypochlorite In water at 0℃; for 0.166667h; Temperature; Time; | 98% |
ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
Conditions | Yield |
---|---|
With sodium hydroxide In toluene at 65℃; for 0.75h; | 98% |
With sodium hydroxide In ethanol; water at 50 - 80℃; for 3h; | 95% |
With water; sodium hydroxide | 95% |
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
Conditions | Yield |
---|---|
With water; sodium hydroxide In methanol at 60℃; for 4h; | 96.3% |
3‐difluoromethyl‐1‐methylpyrazole-4-carbonyl chloride
C12H13Cl2NO
A
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 3‐difluoromethyl‐1‐methylpyrazole-4-carbonyl chloride; C12H13Cl2NO With triethylamine In 1,4-dioxane at 25 - 82℃; for 3h; Stage #2: With sodium hydroxide In tert-butyl methyl ether; water for 0.5h; Stage #3: With hydrogenchloride In tert-butyl methyl ether; water | A 96% B 92% |
3-difluoromethyl-1-methyl-1H-pyrazole-4-carbonitrile
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
Conditions | Yield |
---|---|
With sodium hydroxide In water at 90 - 100℃; | 95% |
Stage #1: 3-difluoromethyl-1-methyl-1H-pyrazole-4-carbonitrile With water; sodium hydroxide at 95℃; for 4h; Stage #2: With hydrogenchloride; water at 20℃; Cooling with ice; | 92% |
With water; sodium hydroxide In methanol for 2h; Solvent; Reflux; Further stages; | 92.1% |
With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide In water; toluene at 70℃; for 8h; |
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
Conditions | Yield |
---|---|
With water; sodium hydroxide at 60℃; for 2h; | 95% |
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
Conditions | Yield |
---|---|
With manganese(II) nitrate; oxygen; acetic acid; ferric nitrate at 80℃; for 20h; | 95% |
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 3-(difluoromethyl)-1-methyl-4-(1,3-dioxolan-2-yl)-1H-pyrazole With hydrogenchloride In water at 50 - 60℃; for 5h; Stage #2: With dihydrogen peroxide In water at 10 - 100℃; for 5h; Reagent/catalyst; | 93.2% |
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 3-(difluoromethyl)-1-methyl-4-(2-methyl-1,3-dioxan-2-yl)-1H-pyrazole With hydrogenchloride In water at 50 - 60℃; for 5h; Stage #2: With dihydrogen peroxide In water at 10 - 100℃; for 5h; | 92.3% |
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
Conditions | Yield |
---|---|
With water; sodium hydroxide In methanol at 60℃; for 4h; Reagent/catalyst; | 92% |
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 3-(difluoromethyl)-1-methyl-4-(2-methyl-1,3-dioxepan-2-yl)-1H-pyrazole With hydrogenchloride In water at 50 - 60℃; for 5h; Stage #2: With dihydrogen peroxide In water at 10 - 100℃; for 5h; | 92% |
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 3-(difluoromethyl)-1-methyl-4-(2-methyl-1,3-dioxolan-2-yl)-1H-pyrazole With hydrogenchloride In water at 50 - 60℃; for 5h; Stage #2: With sodium hypochlorite In water at 10 - 100℃; for 5h; | 91.8% |
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 3-(difluoromethyl)-4-(1,3-dioxan-2-yl)-1-methyl-1H-pyrazole With hydrogenchloride In water at 50 - 60℃; for 5h; Stage #2: With dihydrogen peroxide In water at 10 - 100℃; for 5h; Reagent/catalyst; | 91.6% |
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 3-(difluoromethyl)-1-methyl-4-(1,3-dioxepan-2-yl)-1H-pyrazole With hydrogenchloride In water at 50 - 60℃; for 5h; Stage #2: With dihydrogen peroxide In water at 10 - 100℃; for 5h; Reagent/catalyst; | 91.5% |
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
Conditions | Yield |
---|---|
With sodium hypochlorite at 10 - 100℃; for 5h; | 91.3% |
Stage #1: 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde With sodium hydroxide; dihydrogen peroxide In water at 40 - 45℃; for 1.5h; Stage #2: With hydrogenchloride In water pH=2.5; Product distribution / selectivity; | 69 %Chromat. |
With copper(II) oxide; sodium hydroxide In water at 25 - 30℃; for 24h; | 32 g |
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 3-(difluoromethyl)-1-methyl-4-(2-methyl-1,3-dioxetan-2-yl)-1H-pyrazole With hydrogenchloride In water at 50 - 60℃; for 5h; Stage #2: With sodium hypochlorite In water at 10 - 100℃; for 5h; Reagent/catalyst; | 91.3% |
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
Conditions | Yield |
---|---|
With sodium hypochlorite; water In chloroform at 24℃; for 4h; Reagent/catalyst; Inert atmosphere; | 91% |
With sodium hypochlorite; sodium hydroxide In water at 22 - 70℃; for 2h; |
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 3-(difluoromethyl)-4-(1,3-dioxetan-2-yl)-1-methyl-1H-pyrazole With hydrogenchloride In water at 50 - 60℃; for 5h; Stage #2: With sodium hypochlorite In water at 10 - 100℃; for 5h; Reagent/catalyst; | 91% |
A
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
B
5-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
Conditions | Yield |
---|---|
With 1,3-dimethyl-2-imidazolidinone; hydrogen fluoride; triethylamine at 125 - 155℃; Reagent/catalyst; Temperature; Concentration; Autoclave; | A 90.1% B n/a |
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
Conditions | Yield |
---|---|
With sodium periodate; rhodium(III) chloride hydrate In tetrachloromethane; water; acetonitrile at 20℃; for 0.75h; | 90% |
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
Conditions | Yield |
---|---|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In 1,4-dioxane; water at 65 - 75℃; for 1.5h; Solvent; Reagent/catalyst; Inert atmosphere; | 89.2% |
methylhydrazine
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: methylhydrazine With benzaldehyde In water; toluene at 25 - 60℃; for 6.16667h; Inert atmosphere; Stage #2: (E/Z)-ethyl 2-(ethoxymethylene)-4,4-difluoro-3-oxobutanoate In water; toluene at 20 - 30℃; for 19h; Product distribution / selectivity; | 86.1% |
4-bromo-3-(difluoromethyl)-1-methyl-1H-pyrazole
carbon dioxide
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 4-bromo-3-(difluoromethyl)-1-methyl-1H-pyrazole With TurboGrignard In 2-methyltetrahydrofuran at -5℃; for 2h; Inert atmosphere; Heating; Stage #2: carbon dioxide In 2-methyltetrahydrofuran at -25 - 0℃; for 5h; Reagent/catalyst; Solvent; Inert atmosphere; | 84.6% |
ethyl 4,4-difluoro-3-oxobutyrate
methylhydrazine
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: ethyl 4,4-difluoro-3-oxobutyrate With calcium acetate; orthoformic acid triethyl ester at 100 - 110℃; for 2h; Stage #2: methylhydrazine With sodium hydroxide In 5,5-dimethyl-1,3-cyclohexadiene; water at 10 - 20℃; for 0.5h; | 83.3% |
carbon dioxide
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 3-(difluoromethyl)-4-iodo-1-methyl-1H-pyrazole With isopropylmagnesium chloride In tetrahydrofuran at -5℃; for 2h; Inert atmosphere; Heating; Stage #2: carbon dioxide With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at -25 - 0℃; for 5h; Inert atmosphere; | 83.2% |
methylhydrazine
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
Conditions | Yield |
---|---|
With potassium iodide In water at -30 - -20℃; for 2h; Inert atmosphere; | 79.6% |
methylhydrazine
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
Conditions | Yield |
---|---|
With sodium iodide In water at -30 - 20℃; for 2h; Inert atmosphere; | 78.3% |
methylhydrazine
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
Conditions | Yield |
---|---|
With sodium iodide at -30 - -25℃; for 2h; Inert atmosphere; | 77.1% |
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
Conditions | Yield |
---|---|
With methylhydrazine; potassium iodide In water at -30 - -20℃; for 2h; Inert atmosphere; | 75.9% |
methylhydrazine
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
Conditions | Yield |
---|---|
With sodium iodide at -30 - -20℃; for 2h; Inert atmosphere; | 75.8% |
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
3‐difluoromethyl‐1‐methylpyrazole-4-carbonyl chloride
Conditions | Yield |
---|---|
With thionyl chloride In chlorobenzene at 110℃; for 3h; | 98% |
With thionyl chloride In toluene at 90℃; | 92.1% |
With thionyl chloride; N,N-dimethyl-formamide In 1,2-dichloro-ethane for 5h; Reflux; | 90% |
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
1-methyl-3-(difluoromethyl)-1H-pyrazole-4-amide
Conditions | Yield |
---|---|
Stage #1: 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 0.5h; Stage #2: With ammonium hydroxide In dichloromethane Cooling with ice; | 98% |
Multi-step reaction with 2 steps 1: thionyl chloride / 4 h / Reflux 2: ammonium hydroxide / dichloromethane / 4 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: thionyl chloride / 4 h / Reflux 2: ammonium hydroxide / tetrahydrofuran View Scheme | |
Multi-step reaction with 2 steps 1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C 2: ammonium hydroxide / dichloromethane / 0 °C View Scheme | |
Stage #1: 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: With ammonium hydroxide at 0 - 20℃; |
methanol
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
Conditions | Yield |
---|---|
With sulfuric acid at 75℃; for 8h; | 97.2% |
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
tert-butyl alcohol
Conditions | Yield |
---|---|
With diphenylphosphoranyl azide; N-ethyl-N,N-diisopropylamine at 20 - 90℃; for 4.16667h; Inert atmosphere; | 94% |
With diphenyl phosphoryl azide; N-ethyl-N,N-diisopropylamine at 20 - 90℃; for 4.16667h; Curtius Rearrangement; Inert atmosphere; | 94% |
With diphenyl phosphoryl azide; N-ethyl-N,N-diisopropylamine at 20 - 90℃; for 4.5h; Inert atmosphere; | 91% |
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
Conditions | Yield |
---|---|
With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine In dichloromethane at 20℃; for 21h; | 92.6% |
Conditions | Yield |
---|---|
With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine In dichloromethane at 20℃; for 3h; | 91.7% |
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
Conditions | Yield |
---|---|
With diphenylphosphoranyl azide; N-ethyl-N,N-diisopropylamine In tert-butyl alcohol at 20 - 90℃; for 4.5h; Inert atmosphere; | 91% |
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
N,O-dimethylhydroxylamine*hydrochloride
Conditions | Yield |
---|---|
Stage #1: 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 0.5h; Stage #2: N,O-dimethylhydroxylamine*hydrochloride In dichloromethane at 20℃; | 91% |
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; | 91% |
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
Conditions | Yield |
---|---|
With potassium iodate; sulfuric acid; iodine; acetic acid In sulfolane at 45 - 60℃; for 1.33h; | 90% |
Multi-step reaction with 3 steps 1.1: diphenylphosphoranyl azide; N-ethyl-N,N-diisopropylamine / 4.17 h / 20 - 90 °C / Inert atmosphere 2.1: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C 3.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 °C 3.2: 0.5 h View Scheme | |
Multi-step reaction with 3 steps 1.1: N-ethyl-N,N-diisopropylamine; diphenyl phosphoryl azide / 4.17 h / 20 - 90 °C / Inert atmosphere 2.1: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C 3.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 °C 3.2: 0.5 h / 20 °C View Scheme |
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0℃; for 2h; Inert atmosphere; Stage #2: C12H17BrN2O2S In dichloromethane at 0℃; for 3h; Inert atmosphere; | 90% |
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