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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

3-(DIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID

Cas:176969-34-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid CAS 176969-34-9 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/

3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid CAS 176969-34-9

Cas:176969-34-9

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

3-(Difluoromethyl)-1-Methyl-1H-Pyrazole-4-Carboxylic Acid

Cas:176969-34-9

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Cas:176969-34-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Tianfu Chemical, built in 2009, is a professional supplier for API materials in China. With 10 years development, we have bulit our own factory and lab to produce a certain of products. And we have established stable business relationships with ma

TIANFU 176969-34-9 3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Cas:176969-34-9

Min.Order:1 Kilogram

FOB Price: $200.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Advantage of Supply of Agrochemical Intermediates CAS 176969-34-9

Cas:176969-34-9

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 176969-34-9 with best quality

Cas:176969-34-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product Name: 3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid Density 1.52g/cm3 Boiling Point 315.9ºC at 760 mmHg Flash Point 144.9ºC Refractive Index 1.533 Vapor Pressur

3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid?? CAS:176969-34-9

Cas:176969-34-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1H-Pyrazole-4-carboxylicacid, 3-(difluoromethyl)-1-methyl- 176969-34-9

Cas:176969-34-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Cas:176969-34-9

Min.Order:1 Kilogram

FOB Price: $240.0 / 260.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid CAS:176969-34-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, spe

3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid CAS:176969-34-9

Cas:176969-34-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1H-Pyrazole-4-carboxylicacid, 3-(difluoromethyl)-1-methyl-

Cas:176969-34-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:176969-34-9

Cas:176969-34-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei Mojin Biotechnology Co.,Ltd

Product quality: Our company have high quality product , and also the product we have good manufacture . First of all, this product is of fine quality. Every finish should be checked by quality inspection system.And every one should be also tried

4-Carboxy-3-difluoromethyl-1-methyl pyrazole CAS NO.176969-34-9

Cas:176969-34-9

Min.Order:1 Kilogram

FOB Price: $20.0 / 30.0

Type:Trading Company

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Triumph International Development Limilted

Appearance:white powder/crystal Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/Ai

176969-34-9

Cas:176969-34-9

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We have s

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Cas:176969-34-9

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Cas:176969-34-9

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

3-(DIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID

Cas:176969-34-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

1H-Pyrazole-4-carboxylicacid, 3-(difluoromethyl)-1-methyl-

Cas:176969-34-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products 3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Cas:176969-34-9

Min.Order:100 Gram

Negotiable

Type:Other

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Shanghai Send Pharmaceutical Technology Co., Ltd.

low price high quality high purity good sevice stock Appearance:white Storage:Preserve In Well-Closed, Light-Resistant and Tight Containers. Store In Cool & Dry Place Package:1g,5g,10g...1kg,5kg...more Application:Pharmaceutical intermediat

3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Cas:176969-34-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid/High quality/Best price

Cas:176969-34-9

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Cas:176969-34-9

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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hangzhou verychem science and technology co.ltd

Hangzhou Verychem Science And Technology Co. Ltd. was set up in year 2004, it’s a young but fast growing company. In the twelve years history, it invested two pharmaceutical raw material production plants, one researching company, and several

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Cas:176969-34-9

Min.Order:1 Metric Ton

FOB Price: $80.0

Type:Manufacturers

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YUNBIO TECH CO.,LTD

Our Strength:-Flexible: We work in small teams with rapid communication channels. Respond quickly and efficiently to customer and market needs.-Innovative: We are focusing on the development of new products and keep close relationships with our custo

3-(DIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID

Cas:176969-34-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: 3-Difluoromethyl-1-Methyl-1H-Pyrazol-4-Carboxylicacid CAS No.: 176969-34-9 Molecule Formula:C6H6F2N2O2 Molecule Weight:176.12 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Sta

Lower Price 3-Difluoromethyl-1-Methyl-1H-Pyrazol-4-Carboxylicacid on stock

Cas:176969-34-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

3-(DIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID

Cas:176969-34-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Factory Sells3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Cas:176969-34-9

Min.Order:0

Negotiable

Type:Trading Company

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Synthetic route

1-(3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)ethan-1-one

1-(3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)ethan-1-one

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
With manganese(II) acetate dihydrate; acetic acid at 100℃; for 18h; Reagent/catalyst;100%
With sodium hypochlorite; sodium hydroxide In water at 70℃; for 2h; Temperature; Reagent/catalyst;98%
With sodium hypochlorite In water at 0℃; for 0.166667h; Temperature; Time;98%
ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate
141573-95-7

ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
With sodium hydroxide In toluene at 65℃; for 0.75h;98%
With sodium hydroxide In ethanol; water at 50 - 80℃; for 3h;95%
With water; sodium hydroxide95%
hexylene glycol bis((3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)carboxylate)

hexylene glycol bis((3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)carboxylate)

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
With water; sodium hydroxide In methanol at 60℃; for 4h;96.3%
3‐difluoromethyl‐1‐methylpyrazole-4-carbonyl chloride
141573-96-8

3‐difluoromethyl‐1‐methylpyrazole-4-carbonyl chloride

C12H13Cl2NO
1263184-89-9

C12H13Cl2NO

A

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

B

benzovindiflupyr

benzovindiflupyr

Conditions
ConditionsYield
Stage #1: 3‐difluoromethyl‐1‐methylpyrazole-4-carbonyl chloride; C12H13Cl2NO With triethylamine In 1,4-dioxane at 25 - 82℃; for 3h;
Stage #2: With sodium hydroxide In tert-butyl methyl ether; water for 0.5h;
Stage #3: With hydrogenchloride In tert-butyl methyl ether; water
A 96%
B 92%
3-difluoromethyl-1-methyl-1H-pyrazole-4-carbonitrile
1049772-84-0

3-difluoromethyl-1-methyl-1H-pyrazole-4-carbonitrile

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
With sodium hydroxide In water at 90 - 100℃;95%
Stage #1: 3-difluoromethyl-1-methyl-1H-pyrazole-4-carbonitrile With water; sodium hydroxide at 95℃; for 4h;
Stage #2: With hydrogenchloride; water at 20℃; Cooling with ice;
92%
With water; sodium hydroxide In methanol for 2h; Solvent; Reflux; Further stages;92.1%
With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide In water; toluene at 70℃; for 8h;
hexyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate

hexyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
With water; sodium hydroxide at 60℃; for 2h;95%
methyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate

methyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
With manganese(II) nitrate; oxygen; acetic acid; ferric nitrate at 80℃; for 20h;95%
3-(difluoromethyl)-1-methyl-4-(1,3-dioxolan-2-yl)-1H-pyrazole

3-(difluoromethyl)-1-methyl-4-(1,3-dioxolan-2-yl)-1H-pyrazole

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
Stage #1: 3-(difluoromethyl)-1-methyl-4-(1,3-dioxolan-2-yl)-1H-pyrazole With hydrogenchloride In water at 50 - 60℃; for 5h;
Stage #2: With dihydrogen peroxide In water at 10 - 100℃; for 5h; Reagent/catalyst;
93.2%
3-(difluoromethyl)-1-methyl-4-(2-methyl-1,3-dioxan-2-yl)-1H-pyrazole

3-(difluoromethyl)-1-methyl-4-(2-methyl-1,3-dioxan-2-yl)-1H-pyrazole

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
Stage #1: 3-(difluoromethyl)-1-methyl-4-(2-methyl-1,3-dioxan-2-yl)-1H-pyrazole With hydrogenchloride In water at 50 - 60℃; for 5h;
Stage #2: With dihydrogen peroxide In water at 10 - 100℃; for 5h;
92.3%
ethylene glycol bis((3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)carboxylate)

ethylene glycol bis((3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)carboxylate)

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
With water; sodium hydroxide In methanol at 60℃; for 4h; Reagent/catalyst;92%
3-(difluoromethyl)-1-methyl-4-(2-methyl-1,3-dioxepan-2-yl)-1H-pyrazole

3-(difluoromethyl)-1-methyl-4-(2-methyl-1,3-dioxepan-2-yl)-1H-pyrazole

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
Stage #1: 3-(difluoromethyl)-1-methyl-4-(2-methyl-1,3-dioxepan-2-yl)-1H-pyrazole With hydrogenchloride In water at 50 - 60℃; for 5h;
Stage #2: With dihydrogen peroxide In water at 10 - 100℃; for 5h;
92%
3-(difluoromethyl)-1-methyl-4-(2-methyl-1,3-dioxolan-2-yl)-1H-pyrazole

3-(difluoromethyl)-1-methyl-4-(2-methyl-1,3-dioxolan-2-yl)-1H-pyrazole

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
Stage #1: 3-(difluoromethyl)-1-methyl-4-(2-methyl-1,3-dioxolan-2-yl)-1H-pyrazole With hydrogenchloride In water at 50 - 60℃; for 5h;
Stage #2: With sodium hypochlorite In water at 10 - 100℃; for 5h;
91.8%
3-(difluoromethyl)-4-(1,3-dioxan-2-yl)-1-methyl-1H-pyrazole

3-(difluoromethyl)-4-(1,3-dioxan-2-yl)-1-methyl-1H-pyrazole

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
Stage #1: 3-(difluoromethyl)-4-(1,3-dioxan-2-yl)-1-methyl-1H-pyrazole With hydrogenchloride In water at 50 - 60℃; for 5h;
Stage #2: With dihydrogen peroxide In water at 10 - 100℃; for 5h; Reagent/catalyst;
91.6%
3-(difluoromethyl)-1-methyl-4-(1,3-dioxepan-2-yl)-1H-pyrazole

3-(difluoromethyl)-1-methyl-4-(1,3-dioxepan-2-yl)-1H-pyrazole

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
Stage #1: 3-(difluoromethyl)-1-methyl-4-(1,3-dioxepan-2-yl)-1H-pyrazole With hydrogenchloride In water at 50 - 60℃; for 5h;
Stage #2: With dihydrogen peroxide In water at 10 - 100℃; for 5h; Reagent/catalyst;
91.5%
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde
1094484-55-5

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
With sodium hypochlorite at 10 - 100℃; for 5h;91.3%
Stage #1: 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde With sodium hydroxide; dihydrogen peroxide In water at 40 - 45℃; for 1.5h;
Stage #2: With hydrogenchloride In water pH=2.5; Product distribution / selectivity;
69 %Chromat.
With copper(II) oxide; sodium hydroxide In water at 25 - 30℃; for 24h;32 g
3-(difluoromethyl)-1-methyl-4-(2-methyl-1,3-dioxetan-2-yl)-1H-pyrazole

3-(difluoromethyl)-1-methyl-4-(2-methyl-1,3-dioxetan-2-yl)-1H-pyrazole

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
Stage #1: 3-(difluoromethyl)-1-methyl-4-(2-methyl-1,3-dioxetan-2-yl)-1H-pyrazole With hydrogenchloride In water at 50 - 60℃; for 5h;
Stage #2: With sodium hypochlorite In water at 10 - 100℃; for 5h; Reagent/catalyst;
91.3%
2,2-dichloro-1-(3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)ethanone

2,2-dichloro-1-(3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)ethanone

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
With sodium hypochlorite; water In chloroform at 24℃; for 4h; Reagent/catalyst; Inert atmosphere;91%
With sodium hypochlorite; sodium hydroxide In water at 22 - 70℃; for 2h;
3-(difluoromethyl)-4-(1,3-dioxetan-2-yl)-1-methyl-1H-pyrazole

3-(difluoromethyl)-4-(1,3-dioxetan-2-yl)-1-methyl-1H-pyrazole

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
Stage #1: 3-(difluoromethyl)-4-(1,3-dioxetan-2-yl)-1-methyl-1H-pyrazole With hydrogenchloride In water at 50 - 60℃; for 5h;
Stage #2: With sodium hypochlorite In water at 10 - 100℃; for 5h; Reagent/catalyst;
91%
methyl-3-(dichloromethyl)-1-methyl-1H-pyrazole-4-carboxylate

methyl-3-(dichloromethyl)-1-methyl-1H-pyrazole-4-carboxylate

A

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

B

5-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
1204298-65-6

5-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
With 1,3-dimethyl-2-imidazolidinone; hydrogen fluoride; triethylamine at 125 - 155℃; Reagent/catalyst; Temperature; Concentration; Autoclave;A 90.1%
B n/a
3-(difluoromethyl)-4-(furan-2-yl)-1-methyl-1H-pyrazole

3-(difluoromethyl)-4-(furan-2-yl)-1-methyl-1H-pyrazole

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
With sodium periodate; rhodium(III) chloride hydrate In tetrachloromethane; water; acetonitrile at 20℃; for 0.75h;90%
3-bromo-1-methyl-1H-pyrazole-4-carboxylic acid

3-bromo-1-methyl-1H-pyrazole-4-carboxylic acid

difluoromethylboronic acid

difluoromethylboronic acid

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In 1,4-dioxane; water at 65 - 75℃; for 1.5h; Solvent; Reagent/catalyst; Inert atmosphere;89.2%
(E/Z)-ethyl 2-(ethoxymethylene)-4,4-difluoro-3-oxobutanoate

(E/Z)-ethyl 2-(ethoxymethylene)-4,4-difluoro-3-oxobutanoate

methylhydrazine
60-34-4

methylhydrazine

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
Stage #1: methylhydrazine With benzaldehyde In water; toluene at 25 - 60℃; for 6.16667h; Inert atmosphere;
Stage #2: (E/Z)-ethyl 2-(ethoxymethylene)-4,4-difluoro-3-oxobutanoate In water; toluene at 20 - 30℃; for 19h; Product distribution / selectivity;
86.1%
4-bromo-3-(difluoromethyl)-1-methyl-1H-pyrazole
1089212-38-3

4-bromo-3-(difluoromethyl)-1-methyl-1H-pyrazole

carbon dioxide
124-38-9

carbon dioxide

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
Stage #1: 4-bromo-3-(difluoromethyl)-1-methyl-1H-pyrazole With TurboGrignard In 2-methyltetrahydrofuran at -5℃; for 2h; Inert atmosphere; Heating;
Stage #2: carbon dioxide In 2-methyltetrahydrofuran at -25 - 0℃; for 5h; Reagent/catalyst; Solvent; Inert atmosphere;
84.6%
ethyl 4,4-difluoro-3-oxobutyrate
352-24-9

ethyl 4,4-difluoro-3-oxobutyrate

methylhydrazine
60-34-4

methylhydrazine

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
Stage #1: ethyl 4,4-difluoro-3-oxobutyrate With calcium acetate; orthoformic acid triethyl ester at 100 - 110℃; for 2h;
Stage #2: methylhydrazine With sodium hydroxide In 5,5-dimethyl-1,3-cyclohexadiene; water at 10 - 20℃; for 0.5h;
83.3%
carbon dioxide
124-38-9

carbon dioxide

3-(difluoromethyl)-4-iodo-1-methyl-1H-pyrazole

3-(difluoromethyl)-4-iodo-1-methyl-1H-pyrazole

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
Stage #1: 3-(difluoromethyl)-4-iodo-1-methyl-1H-pyrazole With isopropylmagnesium chloride In tetrahydrofuran at -5℃; for 2h; Inert atmosphere; Heating;
Stage #2: carbon dioxide With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at -25 - 0℃; for 5h; Inert atmosphere;
83.2%
potassium 2-difluoroacetyl-3-(diethylamino)acrylate

potassium 2-difluoroacetyl-3-(diethylamino)acrylate

methylhydrazine
60-34-4

methylhydrazine

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
With potassium iodide In water at -30 - -20℃; for 2h; Inert atmosphere;79.6%
sodium 2-difluoroacetyl-3-(dimethylamino)acrylate

sodium 2-difluoroacetyl-3-(dimethylamino)acrylate

methylhydrazine
60-34-4

methylhydrazine

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
With sodium iodide In water at -30 - 20℃; for 2h; Inert atmosphere;78.3%
sodium 2-difluoroacetyl-3-(diethylamino)acrylate

sodium 2-difluoroacetyl-3-(diethylamino)acrylate

methylhydrazine
60-34-4

methylhydrazine

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
With sodium iodide at -30 - -25℃; for 2h; Inert atmosphere;77.1%
potassium 2-difluoroacetyl-3-(dimethylamino)acrylate

potassium 2-difluoroacetyl-3-(dimethylamino)acrylate

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
With methylhydrazine; potassium iodide In water at -30 - -20℃; for 2h; Inert atmosphere;75.9%
sodium 2-difluoroacetyl-3-(2,2,6,6-tetramethylpiperidin-1yl)acrylate

sodium 2-difluoroacetyl-3-(2,2,6,6-tetramethylpiperidin-1yl)acrylate

methylhydrazine
60-34-4

methylhydrazine

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
With sodium iodide at -30 - -20℃; for 2h; Inert atmosphere;75.8%
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

3‐difluoromethyl‐1‐methylpyrazole-4-carbonyl chloride
141573-96-8

3‐difluoromethyl‐1‐methylpyrazole-4-carbonyl chloride

Conditions
ConditionsYield
With thionyl chloride In chlorobenzene at 110℃; for 3h;98%
With thionyl chloride In toluene at 90℃;92.1%
With thionyl chloride; N,N-dimethyl-formamide In 1,2-dichloro-ethane for 5h; Reflux;90%
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

1-methyl-3-(difluoromethyl)-1H-pyrazole-4-amide
925689-10-7

1-methyl-3-(difluoromethyl)-1H-pyrazole-4-amide

Conditions
ConditionsYield
Stage #1: 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 0.5h;
Stage #2: With ammonium hydroxide In dichloromethane Cooling with ice;
98%
Multi-step reaction with 2 steps
1: thionyl chloride / 4 h / Reflux
2: ammonium hydroxide / dichloromethane / 4 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: thionyl chloride / 4 h / Reflux
2: ammonium hydroxide / tetrahydrofuran
View Scheme
Multi-step reaction with 2 steps
1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C
2: ammonium hydroxide / dichloromethane / 0 °C
View Scheme
Stage #1: 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: With ammonium hydroxide at 0 - 20℃;
methanol
67-56-1

methanol

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

methyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate

methyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate

Conditions
ConditionsYield
With sulfuric acid at 75℃; for 8h;97.2%
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

tert-butyl alcohol
75-65-0

tert-butyl alcohol

tert-butyl (3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)carbamate

tert-butyl (3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)carbamate

Conditions
ConditionsYield
With diphenylphosphoranyl azide; N-ethyl-N,N-diisopropylamine at 20 - 90℃; for 4.16667h; Inert atmosphere;94%
With diphenyl phosphoryl azide; N-ethyl-N,N-diisopropylamine at 20 - 90℃; for 4.16667h; Curtius Rearrangement; Inert atmosphere;94%
With diphenyl phosphoryl azide; N-ethyl-N,N-diisopropylamine at 20 - 90℃; for 4.5h; Inert atmosphere;91%
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

5-amino-9-syn-isopropyl-benzonorbornene

5-amino-9-syn-isopropyl-benzonorbornene

C20H23F2N3O

C20H23F2N3O

Conditions
ConditionsYield
With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine In dichloromethane at 20℃; for 21h;92.6%
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

C14H19N

C14H19N

C20H23F2N3O

C20H23F2N3O

Conditions
ConditionsYield
With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine In dichloromethane at 20℃; for 3h;91.7%
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

tert-butyl (3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)carbamate

tert-butyl (3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)carbamate

Conditions
ConditionsYield
With diphenylphosphoranyl azide; N-ethyl-N,N-diisopropylamine In tert-butyl alcohol at 20 - 90℃; for 4.5h; Inert atmosphere;91%
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

N-methoxy,N-methyl-1-methyl-3-(difluoromethyl)-1H-pyrazole-4-carboxylic amide

N-methoxy,N-methyl-1-methyl-3-(difluoromethyl)-1H-pyrazole-4-carboxylic amide

Conditions
ConditionsYield
Stage #1: 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 0.5h;
Stage #2: N,O-dimethylhydroxylamine*hydrochloride In dichloromethane at 20℃;
91%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃;91%
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

3-(difluoromethyl)-4-iodo-1-methyl-1H-pyrazole

3-(difluoromethyl)-4-iodo-1-methyl-1H-pyrazole

Conditions
ConditionsYield
With potassium iodate; sulfuric acid; iodine; acetic acid In sulfolane at 45 - 60℃; for 1.33h;90%
Multi-step reaction with 3 steps
1.1: diphenylphosphoranyl azide; N-ethyl-N,N-diisopropylamine / 4.17 h / 20 - 90 °C / Inert atmosphere
2.1: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C
3.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 °C
3.2: 0.5 h
View Scheme
Multi-step reaction with 3 steps
1.1: N-ethyl-N,N-diisopropylamine; diphenyl phosphoryl azide / 4.17 h / 20 - 90 °C / Inert atmosphere
2.1: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C
3.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 °C
3.2: 0.5 h / 20 °C
View Scheme
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
176969-34-9

3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

C12H17BrN2O2S

C12H17BrN2O2S

N-(2-bromophenyl)-2-(1-methyl-3-difluoromethyl-1H-pyrazole-4-carboxylamino)-cyclohexylsulfonamide

N-(2-bromophenyl)-2-(1-methyl-3-difluoromethyl-1H-pyrazole-4-carboxylamino)-cyclohexylsulfonamide

Conditions
ConditionsYield
Stage #1: 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0℃; for 2h; Inert atmosphere;
Stage #2: C12H17BrN2O2S In dichloromethane at 0℃; for 3h; Inert atmosphere;
90%

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