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Chemvon Biotechnology Co. Ltd.

molecular formula:C22H26N2O2S.HBr molecular weight:463.43

Eletriptan hydrobromide

Cas:177834-92-3

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu

Eletriptan hydrobromide 177834-92-3 API with best price

Cas:177834-92-3

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Eletriptan Hydrobromide

Cas:177834-92-3

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Eletriptan hydrobromide 177834-92-3 GMP Manufacturer

Cas:177834-92-3

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

Eletriptan hydrobromide

Cas:177834-92-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

(S)-3-((1-METHYLPYRROLIDIN-2-YL)METHYL)-5-(2-(PHENYLSULFONYL)ETHYL)-1H-INDOLE

Cas:177834-92-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Eletriptan hydrobromide

Cas:177834-92-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

ELETRIPTAN HBR

Cas:177834-92-3

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.

177834-92-3 Eletriptan hydrobromide

Cas:177834-92-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 177834-92-3 with competitive price

Cas:177834-92-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best serv

177834-92-3 Eletriptan Hydrobromide Manufacturer For Treatment Of Migraine

Cas:177834-92-3

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Eletriptan hydrobromide CAS:177834-92-3

Cas:177834-92-3

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Eletriptan hydrobromide 177834-92-3

Cas:177834-92-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Eletriptan hydrobromide

Cas:177834-92-3

Min.Order:10 Gram

FOB Price: $20.0 / 25.0

Type:Trading Company

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Eletriptan hydrobromide

Cas:177834-92-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Eletriptan hydrobromide

Cas:177834-92-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

ShangHai Soyoung Biotechnology Inc

Trade Assurance Get full protection for your orders 100% Product quality protection 100% On-time shipment protection 100% Payment protection Appearance:Yellow brown solid powder Storage:Store at a low temperature of 2℃~8℃. preserve in tight containe

Eletriptan hydrobromide 177834-92-3

Cas:177834-92-3

Min.Order:1 Kilogram

FOB Price: $80.0

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Eletriptan hydrobromide 177834-92-3

Cas:177834-92-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Maytime Bio-Tech Co.,Ltd.

production in commercial lot . Storage:keep from moisture,store in tight container Application:Relieve migraine

Eletriptan hydrobromide

Cas:177834-92-3

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

afine+ELETRIPTAN HYDROBROMIDE

Cas:177834-92-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Eletriptan hydrobromide

Cas:177834-92-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Eletriptan Hydrobromide

Cas:177834-92-3

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

Eletriptan hydrobromideAppearance:powder Storage:store in cool, dry place Package:according to customers' requirements Application:177834-92-3 Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or CNF ect...)or according to

Eletriptan hydrobromide

Cas:177834-92-3

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Shanghai Minstar Chemical Co., Ltd

Eletriptan hydrobromide Basic information Product Name: Eletriptan hydrobromide Synonyms: Unii-m41W832ta3;Relpax Also see: E505000;Eletriptan HCl;1H-Indole,3-[[(2R)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenylsulfonyl)ethyl]-,hydrobromide;(R)-

Eletriptan hydrobromide

Cas:177834-92-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

Eletriptan hydrobromide

Cas:177834-92-3

Min.Order:0

Negotiable

Type:Other

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Eletriptan hydrobromide

Cas:177834-92-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:Active Pharmaceutical I

Eletriptan hydrobromide

Cas:177834-92-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

supplier in China Appearance:Tan solid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:100g/bottle,1kg/bottle,25kg/drum or as per your request Application:A second generation triptan drug used in the treatment

Eletriptan hydrobromide-

Cas:177834-92-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Eletriptan hydrobromide

Cas:177834-92-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

eletriptan
143322-58-1

eletriptan

eletriptan hydrobromide
177834-92-3

eletriptan hydrobromide

Conditions
ConditionsYield
With hydrogen bromide In acetone at 20℃; for 0.25h; Product distribution / selectivity;98.34%
With hydrogen bromide In water; butanone Industry scale;96.3%
With hydrogen bromide In water; acetone at -45 - 15℃; Product distribution / selectivity;90%
(R)-5-(2-phenylsulphonylethenyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole hydrobromide
143577-60-0

(R)-5-(2-phenylsulphonylethenyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole hydrobromide

eletriptan hydrobromide
177834-92-3

eletriptan hydrobromide

Conditions
ConditionsYield
Stage #1: (R)-5-(2-phenylsulphonylethenyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole hydrobromide With hydrogen; palladium 10% on activated carbon In methanol at 40℃; under 3677.86 Torr;
Stage #2: With hydrogen bromide In isopropyl alcohol at 25 - 70℃; for 5h; Product distribution / selectivity;
88.33%
3-(N-methyl-2(R)-pyrrolidinylmethyl)-5-(2-phenylsulphonylethyl)-1H-indole hydrobromide monohydrate
273211-28-2

3-(N-methyl-2(R)-pyrrolidinylmethyl)-5-(2-phenylsulphonylethyl)-1H-indole hydrobromide monohydrate

eletriptan hydrobromide
177834-92-3

eletriptan hydrobromide

Conditions
ConditionsYield
In water; acetone at 20℃; for 120h; Product distribution / selectivity;
In ethanol; ethyl acetate at 20 - 80℃; for 17.5h; Product distribution / selectivity;
In water; ethyl acetate at 10 - 80℃; for 3.5h; Product distribution / selectivity;
3-[[(R)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenyl-sulfonyl)ethyl]indole para-toluenesulfonate
1162655-06-2

3-[[(R)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenyl-sulfonyl)ethyl]indole para-toluenesulfonate

eletriptan hydrobromide
177834-92-3

eletriptan hydrobromide

Conditions
ConditionsYield
Stage #1: 3-[[(R)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenyl-sulfonyl)ethyl]indole para-toluenesulfonate With ammonia In tert-butyl methyl ether; water pH=10.5 - 11.0;
Stage #2: With sodium carbonate In tert-butyl methyl ether; water
Stage #3: With hydrogen bromide In ipa; acetone pH=6.6 - 7.5; Product distribution / selectivity;
Stage #1: 3-[[(R)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenyl-sulfonyl)ethyl]indole para-toluenesulfonate With ammonia In tert-butyl methyl ether; water pH=10.5 - 11.0;
Stage #2: With sodium carbonate In tert-butyl methyl ether; water
Stage #3: With hydrogen bromide In ipa pH=6.6 - 7.5; Product distribution / selectivity;
(R)-5-[2-(phenylsulfonyl)ethyl]-3-[(1-methyl-2-pyrrolidinyl)methyl]-1H-indole hemioxalate

(R)-5-[2-(phenylsulfonyl)ethyl]-3-[(1-methyl-2-pyrrolidinyl)methyl]-1H-indole hemioxalate

eletriptan hydrobromide
177834-92-3

eletriptan hydrobromide

Conditions
ConditionsYield
With hydrogen bromide In water; isopropyl alcohol at 25 - 30℃; for 2.5 - 3h; pH=6 - 7; Product distribution / selectivity;
With hydrogen bromide In water; ethyl acetate at 25 - 30℃; for 2.5 - 3h; Product distribution / selectivity;
With hydrogen bromide In water; acetone at 25 - 30℃; for 2.5h; pH=6 - 7; Product distribution / selectivity;
3-{[(2R)-1-methylpyrrolidin-2-yl] methyl}-5-[(E)-2-(phenylsulfonyl)ethenyl]-1H-indole hydrobromide

3-{[(2R)-1-methylpyrrolidin-2-yl] methyl}-5-[(E)-2-(phenylsulfonyl)ethenyl]-1H-indole hydrobromide

eletriptan hydrobromide
177834-92-3

eletriptan hydrobromide

Conditions
ConditionsYield
With hydrogen; 5% Pd(II)/C(eggshell) In methanol; water at 20 - 25℃; under 3800.26 Torr; Product distribution / selectivity;
With hydrogen; 5% Pd(II)/C(eggshell) In water at 20 - 50℃; Product distribution / selectivity; Autoclave;
5-bromo-3-(1-methylpyrrolidin-2(R)-ylmethyl)-1H-indole

5-bromo-3-(1-methylpyrrolidin-2(R)-ylmethyl)-1H-indole

eletriptan hydrobromide
177834-92-3

eletriptan hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: triethylamine / acetonitrile / 25 - 83 °C
2.1: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / acetonitrile / 25 - 35 °C
2.2: 25 - 83 °C
3.1: potassium carbonate; methanol / 25 - 35 °C
3.2: 25 - 30 °C
4.1: hydrogen / 5% Pd(II)/C(eggshell) / water; acetone / 25 - 35 °C / Inert atmosphere
5.1: sodium hydroxide / ethyl acetate; water / 0.33 h / 25 - 30 °C / pH 7 - 10
5.2: 10.5 h / 20 - 25 °C
View Scheme
Multi-step reaction with 4 steps
1.1: triethylamine / acetonitrile / 25 - 83 °C
2.1: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / acetonitrile / 25 - 35 °C
2.2: 25 - 83 °C
3.1: potassium carbonate; methanol / 25 - 35 °C
3.2: 25 - 35 °C / Inert atmosphere
4.1: sodium hydroxide / ethyl acetate; water / 0.33 h / 25 - 30 °C / pH 7 - 10
4.2: 10.5 h / 20 - 25 °C
View Scheme
(R)-1-acetyl-5-[2-(phenylsulfonyl)ethyenyl]-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole
180637-88-1

(R)-1-acetyl-5-[2-(phenylsulfonyl)ethyenyl]-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole

eletriptan hydrobromide
177834-92-3

eletriptan hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium carbonate; methanol / 25 - 35 °C
1.2: 25 - 30 °C
2.1: hydrogen / 5% Pd(II)/C(eggshell) / water; acetone / 25 - 35 °C / Inert atmosphere
3.1: sodium hydroxide / ethyl acetate; water / 0.33 h / 25 - 30 °C / pH 7 - 10
3.2: 10.5 h / 20 - 25 °C
View Scheme
Multi-step reaction with 2 steps
1.1: potassium carbonate; methanol / 25 - 35 °C
1.2: 25 - 35 °C / Inert atmosphere
2.1: sodium hydroxide / ethyl acetate; water / 0.33 h / 25 - 30 °C / pH 7 - 10
2.2: 10.5 h / 20 - 25 °C
View Scheme
Multi-step reaction with 3 steps
1.1: water; sodium carbonate; methanol / 2 h / 25 - 30 °C
2.1: hydrogen; methanesulfonic acid / 5%-palladium/activated carbon / acetone / 20 °C / 2585.81 Torr
2.2: 0.5 h / 25 - 30 °C
3.1: hydrogen bromide / dichloromethane; water; ethylene glycol / 0.5 h / 5 - 10 °C / Inert atmosphere
View Scheme
C16H19BrN2O

C16H19BrN2O

eletriptan hydrobromide
177834-92-3

eletriptan hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / acetonitrile / 25 - 35 °C
1.2: 25 - 83 °C
2.1: potassium carbonate; methanol / 25 - 35 °C
2.2: 25 - 30 °C
3.1: hydrogen / 5% Pd(II)/C(eggshell) / water; acetone / 25 - 35 °C / Inert atmosphere
4.1: sodium hydroxide / ethyl acetate; water / 0.33 h / 25 - 30 °C / pH 7 - 10
4.2: 10.5 h / 20 - 25 °C
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / acetonitrile / 25 - 35 °C
1.2: 25 - 83 °C
2.1: potassium carbonate; methanol / 25 - 35 °C
2.2: 25 - 35 °C / Inert atmosphere
3.1: sodium hydroxide / ethyl acetate; water / 0.33 h / 25 - 30 °C / pH 7 - 10
3.2: 10.5 h / 20 - 25 °C
View Scheme
(R)-5-(2-phenylsulphonylethyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole methanesulphonate
1261286-61-6

(R)-5-(2-phenylsulphonylethyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole methanesulphonate

eletriptan hydrobromide
177834-92-3

eletriptan hydrobromide

Conditions
ConditionsYield
Stage #1: (R)-5-(2-phenylsulphonylethyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole methanesulphonate With sodium hydroxide In water; ethyl acetate at 25 - 30℃; for 0.333333h; pH=7 - 10;
Stage #2: With hydrogen bromide In water; acetone at 20 - 25℃; for 10.5h; Product distribution / selectivity;
(R)-5-bromo-3-(N-methylpyrrolidine-2-ylmethyl)-1H-indole
143322-57-0

(R)-5-bromo-3-(N-methylpyrrolidine-2-ylmethyl)-1H-indole

eletriptan hydrobromide
177834-92-3

eletriptan hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: isopropyl alcohol; water / 4 h / 20 - 35 °C
2.1: potassium hydroxide / toluene; water / 0.25 h / 21 - 25 °C
2.2: 4 h / 100 °C
3.1: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 5 h / 115 °C
4.1: potassium carbonate; water / methanol
5.1: hydrogen bromide / water / pH 1.5
6.1: hydrogen / 5% Pd(II)/C(eggshell) / water / 20 - 50 °C / Autoclave
View Scheme
Multi-step reaction with 5 steps
1.1: N,N-dimethyl-formamide / 95 - 100 °C
1.2: 0 - 5 °C / pH 8 - 9
2.1: N-ethyl-N,N-diisopropylamine / palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 90 - 95 °C / Inert atmosphere
3.1: water; sodium carbonate; methanol / 2 h / 25 - 30 °C
4.1: hydrogen; methanesulfonic acid / 5%-palladium/activated carbon / acetone / 20 °C / 2585.81 Torr
4.2: 0.5 h / 25 - 30 °C
5.1: hydrogen bromide / dichloromethane; water; ethylene glycol / 0.5 h / 5 - 10 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine / N,N-dimethyl-formamide / 2 h / 90 - 100 °C
1.2: 3 h / Reflux
2.1: water; sodium carbonate; methanol / 2 h / 25 - 30 °C
3.1: hydrogen; methanesulfonic acid / 5%-palladium/activated carbon / acetone
3.3: 0.5 h / 20 °C
View Scheme
(R)-3-[(N-benzyloxycarbonylpyrrolidin-2-yl)carbonyl]-5-bromo-1H-indole
143322-56-9

(R)-3-[(N-benzyloxycarbonylpyrrolidin-2-yl)carbonyl]-5-bromo-1H-indole

eletriptan hydrobromide
177834-92-3

eletriptan hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 60 °C / Reflux
2.1: isopropyl alcohol; water / 4 h / 20 - 35 °C
3.1: potassium hydroxide / toluene; water / 0.25 h / 21 - 25 °C
3.2: 4 h / 100 °C
4.1: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 5 h / 115 °C
5.1: potassium carbonate; water / methanol
6.1: hydrogen bromide / water / pH 1.5
7.1: hydrogen / 5% Pd(II)/C(eggshell) / water / 20 - 50 °C / Autoclave
View Scheme
Multi-step reaction with 3 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 39 h / 25 °C / 760.05 Torr / Inert atmosphere; Reflux
2.1: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / acetonitrile / 75 - 80 °C
3.1: hydrogen / palladium 10% on activated carbon / methanol / 40 °C / 3677.86 Torr
3.2: 5 h / 25 - 70 °C
View Scheme
(R,E)-1-(3-((1-methylpyrrolidin-2-yl)methyl)-5-(2-(phenylsulfonyl)vinyl)-1H-indol-1-yl)ethan-1-one

(R,E)-1-(3-((1-methylpyrrolidin-2-yl)methyl)-5-(2-(phenylsulfonyl)vinyl)-1H-indol-1-yl)ethan-1-one

eletriptan hydrobromide
177834-92-3

eletriptan hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate; water / methanol
2: hydrogen bromide / water / pH 1.5
3: hydrogen / 5% Pd(II)/C(eggshell) / water / 20 - 50 °C / Autoclave
View Scheme
Z-D-proline
6404-31-5

Z-D-proline

eletriptan hydrobromide
177834-92-3

eletriptan hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: oxalyl dichloride / N,N-dimethyl-formamide; toluene / 2.5 h / 20 - 25 °C
2.1: methylmagnesium chloride / tert-butyl methyl ether; tetrahydrofuran / 0.75 h / 20 °C
2.2: 0.5 h / 3 - 20 °C
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 60 °C / Reflux
4.1: isopropyl alcohol; water / 4 h / 20 - 35 °C
5.1: potassium hydroxide / toluene; water / 0.25 h / 21 - 25 °C
5.2: 4 h / 100 °C
6.1: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 5 h / 115 °C
7.1: potassium carbonate; water / methanol
8.1: hydrogen bromide / water / pH 1.5
9.1: hydrogen / 5% Pd(II)/C(eggshell) / water / 20 - 50 °C / Autoclave
View Scheme
Multi-step reaction with 5 steps
1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 25 - 30 °C
2.1: ethylmagnesium bromide / diethyl ether / 2.25 h / 25 °C / 760.05 Torr / Reflux
2.2: 1 h / -30 °C
2.3: 0.17 h / -30 - 30 °C
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 39 h / 25 °C / 760.05 Torr / Inert atmosphere; Reflux
4.1: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / acetonitrile / 75 - 80 °C
5.1: hydrogen / palladium 10% on activated carbon / methanol / 40 °C / 3677.86 Torr
5.2: 5 h / 25 - 70 °C
View Scheme
N-benzyloxycarbonyl-D-proline acid chloride
61350-62-7

N-benzyloxycarbonyl-D-proline acid chloride

eletriptan hydrobromide
177834-92-3

eletriptan hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: methylmagnesium chloride / tert-butyl methyl ether; tetrahydrofuran / 0.75 h / 20 °C
1.2: 0.5 h / 3 - 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 60 °C / Reflux
3.1: isopropyl alcohol; water / 4 h / 20 - 35 °C
4.1: potassium hydroxide / toluene; water / 0.25 h / 21 - 25 °C
4.2: 4 h / 100 °C
5.1: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 5 h / 115 °C
6.1: potassium carbonate; water / methanol
7.1: hydrogen bromide / water / pH 1.5
8.1: hydrogen / 5% Pd(II)/C(eggshell) / water / 20 - 50 °C / Autoclave
View Scheme
Multi-step reaction with 4 steps
1.1: ethylmagnesium bromide / diethyl ether / 2.25 h / 25 °C / 760.05 Torr / Reflux
1.2: 1 h / -30 °C
1.3: 0.17 h / -30 - 30 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 39 h / 25 °C / 760.05 Torr / Inert atmosphere; Reflux
3.1: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / acetonitrile / 75 - 80 °C
4.1: hydrogen / palladium 10% on activated carbon / methanol / 40 °C / 3677.86 Torr
4.2: 5 h / 25 - 70 °C
View Scheme
(R)-1-acetyl-5-bromo-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole
205369-12-6

(R)-1-acetyl-5-bromo-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole

eletriptan hydrobromide
177834-92-3

eletriptan hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 5 h / 115 °C
2: potassium carbonate; water / methanol
3: hydrogen bromide / water / pH 1.5
4: hydrogen / 5% Pd(II)/C(eggshell) / water / 20 - 50 °C / Autoclave
View Scheme
Multi-step reaction with 4 steps
1.1: N-ethyl-N,N-diisopropylamine / palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 90 - 95 °C / Inert atmosphere
2.1: water; sodium carbonate; methanol / 2 h / 25 - 30 °C
3.1: hydrogen; methanesulfonic acid / 5%-palladium/activated carbon / acetone / 20 °C / 2585.81 Torr
3.2: 0.5 h / 25 - 30 °C
4.1: hydrogen bromide / dichloromethane; water; ethylene glycol / 0.5 h / 5 - 10 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: N-ethyl-N,N-diisopropylamine / palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 90 - 95 °C / Inert atmosphere
2.1: water; sodium carbonate; methanol / 2 h / 25 - 30 °C
3.1: hydrogen; methanesulfonic acid / 5%-palladium/activated carbon / acetone
3.3: 0.5 h / 20 °C
View Scheme
5-bromo-3-{[(2R)-1-methylpyrrolidin-2-yl]methyl}-1H-indole ethanedioate
1196663-29-2

5-bromo-3-{[(2R)-1-methylpyrrolidin-2-yl]methyl}-1H-indole ethanedioate

eletriptan hydrobromide
177834-92-3

eletriptan hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: potassium hydroxide / toluene; water / 0.25 h / 21 - 25 °C
1.2: 4 h / 100 °C
2.1: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 5 h / 115 °C
3.1: potassium carbonate; water / methanol
4.1: hydrogen bromide / water / pH 1.5
5.1: hydrogen / 5% Pd(II)/C(eggshell) / water / 20 - 50 °C / Autoclave
View Scheme
(R)-5-(2-Benzenesulphonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole

(R)-5-(2-Benzenesulphonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole

eletriptan hydrobromide
177834-92-3

eletriptan hydrobromide

Conditions
ConditionsYield
Stage #1: (R)-5-(2-Benzenesulphonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole With hydrogen; Raney nickel In methanol under 517.162 - 775.743 Torr; for 5h; Industry scale;
Stage #2: With hydrogen bromide In water; ethyl acetate for 0.5h; Industry scale;
Stage #3: In toluene Reflux; Industry scale;
Multi-step reaction with 2 steps
1: hydrogen bromide / water / pH 1.5
2: hydrogen / 5% Pd(II)/C(eggshell) / water / 20 - 50 °C / Autoclave
View Scheme
Multi-step reaction with 2 steps
1.1: methanesulfonic acid / acetone; water / 0.08 h
1.2: 6 h / 30 °C / 2250.23 Torr
2.1: hydrogen bromide / water; ethanol / 6 h / 20 °C
View Scheme
(R)-5-[(2-phenylsulfonyl)ethenyl]-3-(N-methylpyrrolidine-2-ylmethyl)-1H-indole
180637-89-2

(R)-5-[(2-phenylsulfonyl)ethenyl]-3-(N-methylpyrrolidine-2-ylmethyl)-1H-indole

eletriptan hydrobromide
177834-92-3

eletriptan hydrobromide

Conditions
ConditionsYield
Stage #1: (R)-5-[(2-phenylsulfonyl)ethenyl]-3-(N-methylpyrrolidine-2-ylmethyl)-1H-indole With methanesulfonic acid; hydrogen; 5%-palladium/activated carbon In acetone
Stage #2: With ammonia In dichloromethane; water
Stage #3: With hydrogen bromide In dichloromethane; water at 20℃; for 0.5h;
Multi-step reaction with 2 steps
1.1: hydrogen; methanesulfonic acid / 5%-palladium/activated carbon / acetone / 20 °C / 2585.81 Torr
1.2: 0.5 h / 25 - 30 °C
2.1: hydrogen bromide / dichloromethane; water; ethylene glycol / 0.5 h / 5 - 10 °C / Inert atmosphere
View Scheme
With 10% Pd/C; hydrogen bromide In water; acetone at 25 - 30℃;
Multi-step reaction with 2 steps
1: methanesulfonic acid; 5%-palladium/activated carbon; hydrogen / water; acetone / 0.08 h / 25 - 35 °C / 3800.26 - 4560.31 Torr
2: hydrogen bromide / water; isopropyl alcohol / 4 - 5 h / 25 - 35 °C
View Scheme
eletriptan hydrobromide
177834-92-3

eletriptan hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: triethylamine / N,N-dimethyl-formamide / 2 h / 90 - 100 °C
1.2: 3 h / Reflux
2.1: water; sodium carbonate; methanol / 2 h / 25 - 30 °C
3.1: hydrogen; methanesulfonic acid / 5%-palladium/activated carbon / acetone / 20 °C / 2585.81 Torr
3.2: 0.5 h / 25 - 30 °C
4.1: hydrogen bromide / dichloromethane; water; ethylene glycol / 0.5 h / 5 - 10 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine / N,N-dimethyl-formamide / 2 h / 90 - 100 °C
1.2: 3 h / Reflux
2.1: water; sodium carbonate; methanol / 2 h / 25 - 30 °C
3.1: hydrogen; methanesulfonic acid / 5%-palladium/activated carbon / acetone
3.3: 0.5 h / 20 °C
View Scheme
(R)-pyrrolidine-1,2-dicarboxylic acid 1-phenyl ester
105370-80-7

(R)-pyrrolidine-1,2-dicarboxylic acid 1-phenyl ester

eletriptan hydrobromide
177834-92-3

eletriptan hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 3 h / Reflux
2.1: ethylmagnesium bromide; zinc(II) chloride / dichloromethane; tetrahydrofuran / 5 - 30 °C
2.2: -10 - 25 °C
3.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 10 - 50 °C / Inert atmosphere; Darkness
3.2: 0 - 35 °C / pH 12 - 13
4.1: N,N-dimethyl-formamide / 95 - 100 °C
4.2: 0 - 5 °C / pH 8 - 9
5.1: N-ethyl-N,N-diisopropylamine / palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 90 - 95 °C / Inert atmosphere
6.1: water; sodium carbonate; methanol / 2 h / 25 - 30 °C
7.1: hydrogen; methanesulfonic acid / 5%-palladium/activated carbon / acetone / 20 °C / 2585.81 Torr
7.2: 0.5 h / 25 - 30 °C
8.1: hydrogen bromide / dichloromethane; water; ethylene glycol / 0.5 h / 5 - 10 °C / Inert atmosphere
View Scheme
Multi-step reaction with 6 steps
1.1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 3 h / Reflux
2.1: ethylmagnesium bromide; zinc(II) chloride / dichloromethane; tetrahydrofuran / 5 - 30 °C
2.2: -10 - 25 °C
3.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 10 - 50 °C / Inert atmosphere; Darkness
3.2: 0 - 35 °C / pH 12 - 13
4.1: triethylamine / N,N-dimethyl-formamide / 2 h / 90 - 100 °C
4.2: 3 h / Reflux
5.1: water; sodium carbonate; methanol / 2 h / 25 - 30 °C
6.1: hydrogen; methanesulfonic acid / 5%-palladium/activated carbon / acetone
6.3: 0.5 h / 20 °C
View Scheme
Multi-step reaction with 7 steps
1.1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 3 h / Reflux
2.1: ethylmagnesium bromide; zinc(II) chloride / dichloromethane; tetrahydrofuran / 5 - 30 °C
2.2: -10 - 25 °C
3.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 10 - 50 °C / Inert atmosphere; Darkness
3.2: 0 - 35 °C / pH 12 - 13
4.1: triethylamine / N,N-dimethyl-formamide / 2 h / 90 - 100 °C
4.2: 3 h / Reflux
5.1: water; sodium carbonate; methanol / 2 h / 25 - 30 °C
6.1: hydrogen; methanesulfonic acid / 5%-palladium/activated carbon / acetone / 20 °C / 2585.81 Torr
6.2: 0.5 h / 25 - 30 °C
7.1: hydrogen bromide / dichloromethane; water; ethylene glycol / 0.5 h / 5 - 10 °C / Inert atmosphere
View Scheme
Multi-step reaction with 7 steps
1.1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 3 h / Reflux
2.1: ethylmagnesium bromide; zinc(II) chloride / dichloromethane; tetrahydrofuran / 5 - 30 °C
2.2: -10 - 25 °C
3.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 10 - 50 °C / Inert atmosphere; Darkness
3.2: 0 - 35 °C / pH 12 - 13
4.1: N,N-dimethyl-formamide / 95 - 100 °C
4.2: 0 - 5 °C / pH 8 - 9
5.1: N-ethyl-N,N-diisopropylamine / palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 90 - 95 °C / Inert atmosphere
6.1: water; sodium carbonate; methanol / 2 h / 25 - 30 °C
7.1: hydrogen; methanesulfonic acid / 5%-palladium/activated carbon / acetone
7.3: 0.5 h / 20 °C
View Scheme
(R)-2-chlorocarbonylpyrrolidine-1-carboxylic acid phenyl ester
1353991-67-9

(R)-2-chlorocarbonylpyrrolidine-1-carboxylic acid phenyl ester

eletriptan hydrobromide
177834-92-3

eletriptan hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: ethylmagnesium bromide; zinc(II) chloride / dichloromethane; tetrahydrofuran / 5 - 30 °C
1.2: -10 - 25 °C
2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 10 - 50 °C / Inert atmosphere; Darkness
2.2: 0 - 35 °C / pH 12 - 13
3.1: N,N-dimethyl-formamide / 95 - 100 °C
3.2: 0 - 5 °C / pH 8 - 9
4.1: N-ethyl-N,N-diisopropylamine / palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 90 - 95 °C / Inert atmosphere
5.1: water; sodium carbonate; methanol / 2 h / 25 - 30 °C
6.1: hydrogen; methanesulfonic acid / 5%-palladium/activated carbon / acetone / 20 °C / 2585.81 Torr
6.2: 0.5 h / 25 - 30 °C
7.1: hydrogen bromide / dichloromethane; water; ethylene glycol / 0.5 h / 5 - 10 °C / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1.1: ethylmagnesium bromide; zinc(II) chloride / dichloromethane; tetrahydrofuran / 5 - 30 °C
1.2: -10 - 25 °C
2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 10 - 50 °C / Inert atmosphere; Darkness
2.2: 0 - 35 °C / pH 12 - 13
3.1: triethylamine / N,N-dimethyl-formamide / 2 h / 90 - 100 °C
3.2: 3 h / Reflux
4.1: water; sodium carbonate; methanol / 2 h / 25 - 30 °C
5.1: hydrogen; methanesulfonic acid / 5%-palladium/activated carbon / acetone
5.3: 0.5 h / 20 °C
View Scheme
Multi-step reaction with 6 steps
1.1: ethylmagnesium bromide; zinc(II) chloride / dichloromethane; tetrahydrofuran / 5 - 30 °C
1.2: -10 - 25 °C
2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 10 - 50 °C / Inert atmosphere; Darkness
2.2: 0 - 35 °C / pH 12 - 13
3.1: triethylamine / N,N-dimethyl-formamide / 2 h / 90 - 100 °C
3.2: 3 h / Reflux
4.1: water; sodium carbonate; methanol / 2 h / 25 - 30 °C
5.1: hydrogen; methanesulfonic acid / 5%-palladium/activated carbon / acetone / 20 °C / 2585.81 Torr
5.2: 0.5 h / 25 - 30 °C
6.1: hydrogen bromide / dichloromethane; water; ethylene glycol / 0.5 h / 5 - 10 °C / Inert atmosphere
View Scheme
Multi-step reaction with 6 steps
1.1: ethylmagnesium bromide; zinc(II) chloride / dichloromethane; tetrahydrofuran / 5 - 30 °C
1.2: -10 - 25 °C
2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 10 - 50 °C / Inert atmosphere; Darkness
2.2: 0 - 35 °C / pH 12 - 13
3.1: N,N-dimethyl-formamide / 95 - 100 °C
3.2: 0 - 5 °C / pH 8 - 9
4.1: N-ethyl-N,N-diisopropylamine / palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 90 - 95 °C / Inert atmosphere
5.1: water; sodium carbonate; methanol / 2 h / 25 - 30 °C
6.1: hydrogen; methanesulfonic acid / 5%-palladium/activated carbon / acetone
6.3: 0.5 h / 20 °C
View Scheme
(R)-2-(5-bromo-1H-indole-3-carbonyl)pyrrolidine-1-carboxylic acid phenyl ester
1353991-68-0

(R)-2-(5-bromo-1H-indole-3-carbonyl)pyrrolidine-1-carboxylic acid phenyl ester

eletriptan hydrobromide
177834-92-3

eletriptan hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 10 - 50 °C / Inert atmosphere; Darkness
1.2: 0 - 35 °C / pH 12 - 13
2.1: N,N-dimethyl-formamide / 95 - 100 °C
2.2: 0 - 5 °C / pH 8 - 9
3.1: N-ethyl-N,N-diisopropylamine / palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 90 - 95 °C / Inert atmosphere
4.1: water; sodium carbonate; methanol / 2 h / 25 - 30 °C
5.1: hydrogen; methanesulfonic acid / 5%-palladium/activated carbon / acetone / 20 °C / 2585.81 Torr
5.2: 0.5 h / 25 - 30 °C
6.1: hydrogen bromide / dichloromethane; water; ethylene glycol / 0.5 h / 5 - 10 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 10 - 50 °C / Inert atmosphere; Darkness
1.2: 0 - 35 °C / pH 12 - 13
2.1: triethylamine / N,N-dimethyl-formamide / 2 h / 90 - 100 °C
2.2: 3 h / Reflux
3.1: water; sodium carbonate; methanol / 2 h / 25 - 30 °C
4.1: hydrogen; methanesulfonic acid / 5%-palladium/activated carbon / acetone
4.3: 0.5 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 10 - 50 °C / Inert atmosphere; Darkness
1.2: 0 - 35 °C / pH 12 - 13
2.1: N,N-dimethyl-formamide / 95 - 100 °C
2.2: 0 - 5 °C / pH 8 - 9
3.1: N-ethyl-N,N-diisopropylamine / palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 90 - 95 °C / Inert atmosphere
4.1: water; sodium carbonate; methanol / 2 h / 25 - 30 °C
5.1: hydrogen; methanesulfonic acid / 5%-palladium/activated carbon / acetone
5.3: 0.5 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 10 - 50 °C / Inert atmosphere; Darkness
1.2: 0 - 35 °C / pH 12 - 13
2.1: triethylamine / N,N-dimethyl-formamide / 2 h / 90 - 100 °C
2.2: 3 h / Reflux
3.1: water; sodium carbonate; methanol / 2 h / 25 - 30 °C
4.1: hydrogen; methanesulfonic acid / 5%-palladium/activated carbon / acetone / 20 °C / 2585.81 Torr
4.2: 0.5 h / 25 - 30 °C
5.1: hydrogen bromide / dichloromethane; water; ethylene glycol / 0.5 h / 5 - 10 °C / Inert atmosphere
View Scheme
(R)-5-bromo-3-(N-methylpyrrolidine-2-ylmethyl)-1H-indole
143322-57-0

(R)-5-bromo-3-(N-methylpyrrolidine-2-ylmethyl)-1H-indole

eletriptan hydrobromide
177834-92-3

eletriptan hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / acetonitrile / 75 - 80 °C
2.1: hydrogen / palladium 10% on activated carbon / methanol / 40 °C / 3677.86 Torr
2.2: 5 h / 25 - 70 °C
View Scheme
tert-butyl (R,E)-3-((1-methylpyrrolidin-2-yl)methyl)-5-(2-(phenylsulfonyl)vinyl)-1H-indole-1-carboxylate hydrobromide

tert-butyl (R,E)-3-((1-methylpyrrolidin-2-yl)methyl)-5-(2-(phenylsulfonyl)vinyl)-1H-indole-1-carboxylate hydrobromide

eletriptan hydrobromide
177834-92-3

eletriptan hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C
2.1: methanesulfonic acid / acetone; water / 0.08 h
2.2: 6 h / 30 °C / 2250.23 Torr
3.1: hydrogen bromide / water; ethanol / 6 h / 20 °C
View Scheme
tert-butyl (R)-5-bromo-3-((1-methylpyrrolidin-2-yl)methyl)-1H-indole-1-carboxylate

tert-butyl (R)-5-bromo-3-((1-methylpyrrolidin-2-yl)methyl)-1H-indole-1-carboxylate

eletriptan hydrobromide
177834-92-3

eletriptan hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: tris-(o-tolyl)phosphine; triethylamine; palladium diacetate / acetonitrile / 15 h / Inert atmosphere; Reflux
2.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C
3.1: methanesulfonic acid / acetone; water / 0.08 h
3.2: 6 h / 30 °C / 2250.23 Torr
4.1: hydrogen bromide / water; ethanol / 6 h / 20 °C
View Scheme
eletriptan hydrobromide
177834-92-3

eletriptan hydrobromide

4-methyl-8-[2-(phenylsulfonyl)ethyl]-1,2,3,5,10,10a-hexahydropyrrolidino[3,2-b]indol-4-ium
1408337-90-5

4-methyl-8-[2-(phenylsulfonyl)ethyl]-1,2,3,5,10,10a-hexahydropyrrolidino[3,2-b]indol-4-ium

Conditions
ConditionsYield
With dihydrogen peroxide In water; acetonitrile at 80 - 85℃; for 0.75h;60%
eletriptan hydrobromide
177834-92-3

eletriptan hydrobromide

3-(N-methyl-2(R)-pyrrolidinylmethyl)-5-(2-phenylsulphonylethyl)-1H-indole hydrobromide monohydrate
273211-28-2

3-(N-methyl-2(R)-pyrrolidinylmethyl)-5-(2-phenylsulphonylethyl)-1H-indole hydrobromide monohydrate

Conditions
ConditionsYield
With water at 60℃; under 20 Torr; for 16h; Product distribution / selectivity;
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