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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

3-Hydroxyazetidine hydrochloride

Cas:18621-18-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 3-Hydroxyazetidine Hydrochloride supplier in China

Cas:18621-18-6

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com Product Name 3-Hydroxyazetidine hydrochloride CAS No.

3-Hydroxyazetidine hydrochloride

Cas:18621-18-6

Min.Order:1 Gram

FOB Price: $8.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

Manufacturer supply 3-Hydroxyazetidine hydrochloride CAS 18621-18-6 with attractive price Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its inte

Manufacturer supply 3-Hydroxyazetidine hydrochloride CAS 18621-18-6 with attractive price

Cas:18621-18-6

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay (Ursolic acid) 98%min 98.22% -----------------------------------------------------------------------------------------------------------

High purity 3-hydroxyazetidine hydrochloride 18621-18-6,98%min

Cas:18621-18-6

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

3-Hydroxyazetidine hydrochloride CAS No.:18621-18-6 Name: 3-Hydroxyazetidine hydrochloride Molecular Structure Molecular Formula: C3H7NO.HCl Molecular Weight: 109.55 CAS Registry Number: 18621-18-6 Appe

High purity 3-Hydroxyazetidine hydrochloride CAS No.:18621-18-6

Cas:18621-18-6

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

3-Hydroxyazetidine Hydrochloride

Cas:18621-18-6

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Large Stock 99.0% Azetidin-3-ol HCl 18621-18-6 Producer

Cas:18621-18-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

3-Hydroxyazetidine hydrochloride

Cas:18621-18-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3-Hydroxyazetidine hydrochloride

Cas:18621-18-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Leader Biochemical Group

About Product Details

China Biggest factory Manufacturer Supply High Quality 3-Hydroxyazetidine Hydrochloride CAS 18621-18-6

Cas:18621-18-6

Min.Order:1 Kilogram

FOB Price: $1.0 / 5.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

CAS: 18621-18-6 EINECS: 628-004-3 Chemical formula: C3H8ClNO Molecular weight: 109.55 InchI: InchI=1/C3H7NO. ClH/c5-3-1-4-2-3/ H3-5H, 1-2H2; 1H InchIKey UQUPQEUNHVVNKW-UHFFAOYSA-N Melting point: 85-90 ° C Boiling point: 170.7 ° C at 760 mmHg

3-Hydroxyazetidine hydrochloride 18621-18-6

Cas:18621-18-6

Min.Order:5 Kilogram

FOB Price: $20.0 / 80.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 18621-18-6 with best quality

Cas:18621-18-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

3-Hydroxyazetidine hydrochloride/ LIDE PHARMA- Factory supply / Best price

Cas:18621-18-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

Name: Azetidin-3-ol HCl Synonyms: 3-(Hydroxy)azetidine Hydrochloride CAS:18621-18-6 MF: C3H8ClNO Appearance: white powder Storage:Store in cool and dry place, away from sun light. Package: 25kgs/drum Application: Pharmaceutical Intermediate Tr

Azetidin-3-ol HCl

Cas:18621-18-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

3-Hydroxyazetidine hydrochloride 18621-18-6

Cas:18621-18-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

3-Hydroxyazetidine hydrochloride CAS:18621-18-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality

3-Hydroxyazetidine hydrochloride CAS:18621-18-6

Cas:18621-18-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

3-Hydroxyazetidine hydrochloride

Cas:18621-18-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

3-Hydroxyazetidine Hydrochloride

Cas:18621-18-6

Min.Order:0

Negotiable

Type:Manufacturers

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Triumph International Development Limilted

Appearance:White or off-white Solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Se

Azetidin-3-ol HCl

Cas:18621-18-6

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

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Zhengzhou Yuanli Biological Technology Co., Ltd.

Product Name:3-Hydroxyazetidine hydrochloride Appearance: White crystal CAS No.:18621-18-6 MF:C3H8ClNO MW:109.55 EINECS NO :628-004-3 Assay : 97% Packaging details: 25kg/Drum Shipping: Within 3 days after get your payment Advantages: 1. IS

Biggest manufacturer of 3-Hydroxyazetidine hydrochloride

Cas:18621-18-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

CAS 18621-18-6 3-Hydroxyazetidine hydrochloride

Cas:18621-18-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

3-Hydroxyazetidine hydrochloride

Cas:18621-18-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

3-HYDROXYAZETIDINE HYDROCHLORIDE

Cas:18621-18-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3-Hydroxyazetidine hydrochloride

Cas:18621-18-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

azetidin-3-ol hydrochloride

Cas:18621-18-6

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Hope Chem Co., Ltd

1. Product advantages: exquisite appearance and unique functions. 2. Product Advantages: Our products are the best,fast speed ,in large stock 3. High-quality products and thoughtful service are your greatest satisfaction. 4. The product

3-Hydroxyazetidine hydrochloride

Cas:18621-18-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

our strengths: 1: Fast and guaranteed shipment (TNT;EMS;FEDEX;DHL;UPS;EUB, special line) 2: Various payment items accepted (Btc; MoneyGram; WU) 3: Valued package (Paraffin coating; Double aluminum foil bag; Vacuum packaging) 4: Efficient delivery

High purity 3-Hydroxyazetidine hydrochloride with lower price

Cas:18621-18-6

Min.Order:1 Gram

Negotiable

Type:Other

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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured productsAzetidin-3-ol hydrochloride

Cas:18621-18-6

Min.Order:100 Gram

Negotiable

Type:Other

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

3-Hydroxyazetidine hydrochloride/High quality/Best price

Cas:18621-18-6

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Synthetic route

1-(diphenylmethyl)-3-azetidinol hydrochloride
90604-02-7

1-(diphenylmethyl)-3-azetidinol hydrochloride

azetion-3-ol hydrochloride
18621-18-6

azetion-3-ol hydrochloride

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In ethanol; water at 20℃; under 2625.21 Torr; for 4h;100%
With palladium hydroxide on carbon; hydrogen In ethanol at 20℃; under 3040.2 Torr; for 12h; Inert atmosphere;94%
With hydrogen; palladium hydroxide on carbon In ethanol at 20℃; under 3040.2 Torr; for 12h;94%
1-acetyl-3-acetoxyazetidine
143329-27-5

1-acetyl-3-acetoxyazetidine

azetion-3-ol hydrochloride
18621-18-6

azetion-3-ol hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In water for 4h; Heating;100%
N-(trityl)-3-hydroxyazetidine

N-(trityl)-3-hydroxyazetidine

azetion-3-ol hydrochloride
18621-18-6

azetion-3-ol hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In chloroform at 0 - 5℃; for 7h; Solvent;95%
C6H10ClNO3

C6H10ClNO3

azetion-3-ol hydrochloride
18621-18-6

azetion-3-ol hydrochloride

Conditions
ConditionsYield
In methanol at 65℃; for 1h;92.6%
1-benzylazetidine-3-ol hydrochloride
223382-13-6

1-benzylazetidine-3-ol hydrochloride

azetion-3-ol hydrochloride
18621-18-6

azetion-3-ol hydrochloride

Conditions
ConditionsYield
With palladium on activated charcoal; hydrogen In ethanol; water at 20℃; under 2585.81 Torr; for 24h; Large scale reaction;90%
hydrogenchloride
7647-01-0

hydrogenchloride

1-(diphenylmethyl)-3-hydroxyazetidine
18621-17-5

1-(diphenylmethyl)-3-hydroxyazetidine

azetion-3-ol hydrochloride
18621-18-6

azetion-3-ol hydrochloride

Conditions
ConditionsYield
With hydrogen; 10% palladium on activated carbon In 1,4-dioxane; methanol at 60℃; under 2068.65 Torr; for 6h;68%
3-benzylidenamino-1-chloropropan-2-ol

3-benzylidenamino-1-chloropropan-2-ol

azetion-3-ol hydrochloride
18621-18-6

azetion-3-ol hydrochloride

Conditions
ConditionsYield
With potassium carbonate In isopropyl alcohol Solvent; Large scale;66%
1-azabicyclo<1.1.0>butane
19540-05-7

1-azabicyclo<1.1.0>butane

azetion-3-ol hydrochloride
18621-18-6

azetion-3-ol hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; formic acid 1.) THF, r.t., 18 h; 2.) MeOH, H2O, r.t., 20 h; Yield given; Multistep reaction;
Stage #1: 1-azabicyclo<1.1.0>butane With acetic anhydride In tetrahydrofuran at 20℃; for 10h;
Stage #2: With hydrogenchloride for 3h; Heating;
tert-butyl 2-hydroxyazetidine-1-carboxylate
848438-92-6

tert-butyl 2-hydroxyazetidine-1-carboxylate

azetion-3-ol hydrochloride
18621-18-6

azetion-3-ol hydrochloride

Conditions
ConditionsYield
Stage #1: tert-butyl 2-hydroxyazetidine-1-carboxylate With trifluoroacetic acid In dichloromethane at 20℃;
Stage #2: With sodium hydroxide In water pH=11;
Stage #3: With hydrogenchloride In 1,4-dioxane
1-benzyl-3-hydroxyazetidine
54881-13-9

1-benzyl-3-hydroxyazetidine

azetion-3-ol hydrochloride
18621-18-6

azetion-3-ol hydrochloride

Conditions
ConditionsYield
Stage #1: N-benzyl-3-hydroxyazetidine With hydrogen; acetic acid; 5% palladium hydroxide on carbon In water at 55 - 65℃; under 2068.65 Torr; for 2 - 8h;
Stage #2: With hydrogenchloride at 5 - 40℃; for 1.5h;
N-tert-butyl-3-hydroxyazetidine
13156-04-2

N-tert-butyl-3-hydroxyazetidine

azetion-3-ol hydrochloride
18621-18-6

azetion-3-ol hydrochloride

Conditions
ConditionsYield
Stage #1: N-tert-butyl-3-hydroxyazetidine With boron trifluoride diethyl etherate; acetic anhydride; tert-butylamine at 112℃; for 14h;
Stage #2: With hydrogenchloride In water at 99℃; for 5h; Temperature;
2-chloro-7-fluoro-5-methyl-6-phenyl-1,3-benzoxazole-4-carbonitrile
927390-34-9

2-chloro-7-fluoro-5-methyl-6-phenyl-1,3-benzoxazole-4-carbonitrile

azetion-3-ol hydrochloride
18621-18-6

azetion-3-ol hydrochloride

7-fluoro-2-(3-hydroxyazetidin-1-yl)-5-methyl-6-phenyl-1,3-benzoxazole-4-carbonitrile
927390-57-6

7-fluoro-2-(3-hydroxyazetidin-1-yl)-5-methyl-6-phenyl-1,3-benzoxazole-4-carbonitrile

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane for 6h; Heating / reflux;100%
azetion-3-ol hydrochloride
18621-18-6

azetion-3-ol hydrochloride

benzyl chloroformate
501-53-1

benzyl chloroformate

1-Benzyloxycarbonyl-3-hydroxyazetidine
128117-22-6

1-Benzyloxycarbonyl-3-hydroxyazetidine

Conditions
ConditionsYield
Stage #1: azetion-3-ol hydrochloride With potassium carbonate In tetrahydrofuran; water at 20 - 25℃; for 0.5h;
Stage #2: benzyl chloroformate In tetrahydrofuran; water at 0 - 25℃;
100%
Stage #1: azetion-3-ol hydrochloride With potassium carbonate In tetrahydrofuran; water at 20 - 25℃; for 0.5h;
Stage #2: benzyl chloroformate In tetrahydrofuran; water at 0 - 25℃;
100%
With potassium carbonate In tetrahydrofuran; water at 0 - 20℃;96%
(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-amine
1223404-88-3

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-amine

azetion-3-ol hydrochloride
18621-18-6

azetion-3-ol hydrochloride

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

(R)-N-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxyazetidine-1-carboxamide
1223403-41-5

(R)-N-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxyazetidine-1-carboxamide

Conditions
ConditionsYield
Stage #1: 5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-amine; 1,1'-carbonyldiimidazole In dichloromethane at 20℃; for 2h;
Stage #2: azetion-3-ol hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane for 0.0833333h;
100%
4-(7-fluoro-quinazolin-4-yl)-piperidine-1-carboxylic acid tert-butyl ester
916731-80-1

4-(7-fluoro-quinazolin-4-yl)-piperidine-1-carboxylic acid tert-butyl ester

azetion-3-ol hydrochloride
18621-18-6

azetion-3-ol hydrochloride

4-[7-(Azetidin-3-yloxy)-quinazolin-4-yl]-piperidine-1-carboxylic acid tert-butyl ester
916733-34-1

4-[7-(Azetidin-3-yloxy)-quinazolin-4-yl]-piperidine-1-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
Stage #1: azetion-3-ol hydrochloride With potassium tert-butylate In dimethyl sulfoxide at 20℃; for 0.5h;
Stage #2: 4-(7-fluoro-quinazolin-4-yl)-piperidine-1-carboxylic acid tert-butyl ester In dimethyl sulfoxide at 20℃; for 3.5h;
100%
4-cyano-4,4-diphenylbutanoic acid
6523-63-3

4-cyano-4,4-diphenylbutanoic acid

azetion-3-ol hydrochloride
18621-18-6

azetion-3-ol hydrochloride

5-(3-hydroxy-azetidin-1-yl)-5-oxo-2,2-diphenylpentanenitrile
1355533-23-1

5-(3-hydroxy-azetidin-1-yl)-5-oxo-2,2-diphenylpentanenitrile

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18h;100%
azetion-3-ol hydrochloride
18621-18-6

azetion-3-ol hydrochloride

4,6-dichloro-2-methoxypyrimidine
1074-40-4

4,6-dichloro-2-methoxypyrimidine

1-(6-iodo-2-methoxypyrimidin-4-yl)azetidin-3-ol

1-(6-iodo-2-methoxypyrimidin-4-yl)azetidin-3-ol

Conditions
ConditionsYield
With triethylamine In isopropyl alcohol at 75℃; for 2h;100%
2-cyclopropyl-4,6-diiodopyrimidine

2-cyclopropyl-4,6-diiodopyrimidine

azetion-3-ol hydrochloride
18621-18-6

azetion-3-ol hydrochloride

1-(2-cyclopropyl-6-iodopyrimidin-4-yl)azetidin-3-ol

1-(2-cyclopropyl-6-iodopyrimidin-4-yl)azetidin-3-ol

Conditions
ConditionsYield
With triethylamine In isopropyl alcohol at 90℃; for 1h;100%
C23H22F2N4O2

C23H22F2N4O2

azetion-3-ol hydrochloride
18621-18-6

azetion-3-ol hydrochloride

C26H29F2N5O2

C26H29F2N5O2

Conditions
ConditionsYield
Stage #1: C23H22F2N4O2; azetion-3-ol hydrochloride With sodium acetate In methanol at 20℃; for 4h;
Stage #2: With sodium tetrahydroborate In methanol at 0 - 20℃; for 1.5h;
100%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

azetion-3-ol hydrochloride
18621-18-6

azetion-3-ol hydrochloride

tert-butyl 3-hydroxyazetidine-1-carboxylate
141699-55-0

tert-butyl 3-hydroxyazetidine-1-carboxylate

Conditions
ConditionsYield
With potassium carbonate In tetrahydrofuran; water for 4h;99%
With triethylamine In methanol at 20℃; for 6h;93%
With triethylamine In methanol at 0 - 20℃; for 6h;93%
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-amine
1218935-62-6

(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-amine

azetion-3-ol hydrochloride
18621-18-6

azetion-3-ol hydrochloride

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

(R)-N-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)-3-hydroxyazetidine-1-carboxamide
1218935-04-6

(R)-N-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)-3-hydroxyazetidine-1-carboxamide

Conditions
ConditionsYield
Stage #1: (R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-amine; 1,1'-carbonyldiimidazole In dichloromethane at 20℃; for 1h;
Stage #2: azetion-3-ol hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.5h;
99%
C23H26BrClN6O4S
1353628-72-4

C23H26BrClN6O4S

azetion-3-ol hydrochloride
18621-18-6

azetion-3-ol hydrochloride

C26H32BrN7O5S
1353623-64-9

C26H32BrN7O5S

Conditions
ConditionsYield
With triethylamine In methanol at 70℃; for 2h;99%
azetion-3-ol hydrochloride
18621-18-6

azetion-3-ol hydrochloride

3,4,5-Trimethoxybenzoyl chloride
4521-61-3

3,4,5-Trimethoxybenzoyl chloride

(3-hydroxyazetidin-1-yl)(3,4,5-trimethoxyphenyl)methanone

(3-hydroxyazetidin-1-yl)(3,4,5-trimethoxyphenyl)methanone

Conditions
ConditionsYield
Stage #1: azetion-3-ol hydrochloride; 3,4,5-Trimethoxybenzoyl chloride With potassium carbonate In water; ethyl acetate at 20℃; for 16h;
Stage #2: With sodium hydroxide In tetrahydrofuran; methanol; water for 20h;
99%
2-bromobenzo[4,5]imidazol[1,2-a]pyrimidine
1320211-47-9

2-bromobenzo[4,5]imidazol[1,2-a]pyrimidine

azetion-3-ol hydrochloride
18621-18-6

azetion-3-ol hydrochloride

1-(benzo[4,5]imidazo[1,2-a]pyrimidin-2-yl)azetidin-3-ol

1-(benzo[4,5]imidazo[1,2-a]pyrimidin-2-yl)azetidin-3-ol

Conditions
ConditionsYield
With triethylamine at 100℃; for 0.166667h; Microwave irradiation;99%
azetion-3-ol hydrochloride
18621-18-6

azetion-3-ol hydrochloride

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

1-(4-methoxybenzyl)azetidin-3-ol
111043-52-8

1-(4-methoxybenzyl)azetidin-3-ol

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride; triethylamine In dichloromethane at 20℃; Inert atmosphere;99%
4-(5-(1-isobutyl-5-(pyridin-4-yl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)benzaldehyde
1258009-72-1

4-(5-(1-isobutyl-5-(pyridin-4-yl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)benzaldehyde

azetion-3-ol hydrochloride
18621-18-6

azetion-3-ol hydrochloride

1-(4-(5-(1-isobutyl-5-(pyridin-4-yl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidin-3-ol
1258009-81-2

1-(4-(5-(1-isobutyl-5-(pyridin-4-yl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidin-3-ol

Conditions
ConditionsYield
With sodium cyanoborohydride; acetic acid In methanol at 20℃;98.5%
1-(4-fluoro-3-nitrophenyl)tetrazole

1-(4-fluoro-3-nitrophenyl)tetrazole

azetion-3-ol hydrochloride
18621-18-6

azetion-3-ol hydrochloride

1-(2-nitro-4-(tetrazol-1-yl)phenyl)azetidin-3-ol

1-(2-nitro-4-(tetrazol-1-yl)phenyl)azetidin-3-ol

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 72h;98%
2,4-difluoro-5-nitrobenzaldehyde

2,4-difluoro-5-nitrobenzaldehyde

azetion-3-ol hydrochloride
18621-18-6

azetion-3-ol hydrochloride

2-fluoro-4-(3-hydroxyazetidin-1-yl)-5-nitrobenzaldehyde

2-fluoro-4-(3-hydroxyazetidin-1-yl)-5-nitrobenzaldehyde

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 0℃; for 0.5h;97.35%
azetion-3-ol hydrochloride
18621-18-6

azetion-3-ol hydrochloride

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid
84358-13-4

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

C14H24N2O4

C14H24N2O4

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃;97%
azetion-3-ol hydrochloride
18621-18-6

azetion-3-ol hydrochloride

4,6-dichloro-2-methoxypyrimidine
1074-40-4

4,6-dichloro-2-methoxypyrimidine

1-(6-chloro-2-methoxypyrimidin-4-yl)azetidin-3-ol

1-(6-chloro-2-methoxypyrimidin-4-yl)azetidin-3-ol

Conditions
ConditionsYield
With triethylamine In isopropyl alcohol at 85℃; for 2h;97%
azetion-3-ol hydrochloride
18621-18-6

azetion-3-ol hydrochloride

5-chloro-2-[[5-methyl-3-(6-methyl-3-pyridyl)isoxazol-4-yl]methyl]pyridazin-3-one

5-chloro-2-[[5-methyl-3-(6-methyl-3-pyridyl)isoxazol-4-yl]methyl]pyridazin-3-one

5-(3-hydroxyazetidin-1-yl)-2-[[5-methyl-3-(6-methyl-3-pyridyl)isoxazol-4-yl]methyl]pyridazin-3-one

5-(3-hydroxyazetidin-1-yl)-2-[[5-methyl-3-(6-methyl-3-pyridyl)isoxazol-4-yl]methyl]pyridazin-3-one

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide; acetonitrile at 70℃; for 18h;97%
1-fluoro-2-nitro-4-trifluoromethyl-benzene
367-86-2

1-fluoro-2-nitro-4-trifluoromethyl-benzene

azetion-3-ol hydrochloride
18621-18-6

azetion-3-ol hydrochloride

1-(2-nitro-4-(trifluoromethyl)phenyl)azetidin-3-ol

1-(2-nitro-4-(trifluoromethyl)phenyl)azetidin-3-ol

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 16h;97%
5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester
1224944-77-7

5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester

azetion-3-ol hydrochloride
18621-18-6

azetion-3-ol hydrochloride

ethyl 5-(3-hydroxyazetidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylate

ethyl 5-(3-hydroxyazetidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 60℃; for 2h; Inert atmosphere;97%
2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazole-5-carboxylic acid
960391-21-3

2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazole-5-carboxylic acid

azetion-3-ol hydrochloride
18621-18-6

azetion-3-ol hydrochloride

1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)azetidin-3-ol
960391-39-3

1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)azetidin-3-ol

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 2h;96%
(R)-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine
1223405-16-0

(R)-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine

azetion-3-ol hydrochloride
18621-18-6

azetion-3-ol hydrochloride

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

(R)-N-(5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxyazetidine-1-carboxamide
1223403-84-6

(R)-N-(5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxyazetidine-1-carboxamide

Conditions
ConditionsYield
Stage #1: (R)-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine; 1,1'-carbonyldiimidazole In dichloromethane at 20℃; for 2h;
Stage #2: azetion-3-ol hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane for 0.0833333h;
96%
1-(6-amino-3,5-difluoro-2-pyridyl)-8-chloro-6-fluoro-1,4-dihydro-7-fluoro-4-oxo-3-quinolinecarboxylic acid ethyl ester
189279-51-4

1-(6-amino-3,5-difluoro-2-pyridyl)-8-chloro-6-fluoro-1,4-dihydro-7-fluoro-4-oxo-3-quinolinecarboxylic acid ethyl ester

azetion-3-ol hydrochloride
18621-18-6

azetion-3-ol hydrochloride

1-(6-amino-3,5-difluoro-2-pyridyl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-hydroxy-1-azetidinyl)-4-oxo-3-quinolinecarboxylic acid ethyl ester

1-(6-amino-3,5-difluoro-2-pyridyl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-hydroxy-1-azetidinyl)-4-oxo-3-quinolinecarboxylic acid ethyl ester

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 60 - 70℃;96%
With 1,8-diazabicyclo[5.4.0]undec-7-ene at 50℃; for 1h; Cooling with ice;28.1 g
azetion-3-ol hydrochloride
18621-18-6

azetion-3-ol hydrochloride

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

1-(p-Toluenesulfonyl)azetidin-3-ol
154010-96-5

1-(p-Toluenesulfonyl)azetidin-3-ol

Conditions
ConditionsYield
Stage #1: azetion-3-ol hydrochloride With triethylamine In methanol at 0 - 20℃; for 0.5h; Inert atmosphere;
Stage #2: p-toluenesulfonyl chloride In methanol at 0 - 20℃; Inert atmosphere;
95%
With triethylamine In dichloromethane at 20℃; for 12h; Schlenk technique;66%
With triethylamine In diethyl ether Yield given;
azetion-3-ol hydrochloride
18621-18-6

azetion-3-ol hydrochloride

Ethanesulfonyl chloride
594-44-5

Ethanesulfonyl chloride

1-ethylsulfonylazetidin-3-ol

1-ethylsulfonylazetidin-3-ol

Conditions
ConditionsYield
With potassium phosphate; sodium hydroxide In tetrahydrofuran; water at 20℃; for 3h;95%
ethyl 2-chloro-1,3-benzoxazole-6-carboxylate

ethyl 2-chloro-1,3-benzoxazole-6-carboxylate

azetion-3-ol hydrochloride
18621-18-6

azetion-3-ol hydrochloride

ethyl 2-(3-hydroxyazetidin-1-yl)-1,3-benzoxazole-6-carboxylate

ethyl 2-(3-hydroxyazetidin-1-yl)-1,3-benzoxazole-6-carboxylate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;95%
With N-ethyl-N,N-diisopropylamine In water; N,N-dimethyl-formamide at 10 - 35℃;19.26 g

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