As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:198904-86-8
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:198904-86-8
Min.Order:0 Metric Ton
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inquiryUnique advantages of Des-N-(methoxycarbonyl)-L-tert-leucine Bis-Boc Atazanavir Cas 198904-86-8 Guaranteed purity High quality & competitive price Quality control Fast feedback Appearance:White powder Storage:cool dry place Package:100g/1kg/fo
Cas:198904-86-8
Min.Order:100 Gram
Negotiable
Type:Trading Company
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:198904-86-8
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:198904-86-8
Min.Order:5 Kiloliter
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Type:Manufacturers
inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/1488.html Product Name 2-[(2S,3S)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-hydroxy -4-phenylbu
Cas:198904-86-8
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryDes-N-(methoxycarbonyl)-L-tert-leucine Bis-Boc Atazanavir Basic information Product Name: Des-N-(methoxycarbonyl)-L-tert-leucine Bis-Boc Atazanavir Synony
Cas:198904-86-8
Min.Order:1 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu
Cas:198904-86-8
Min.Order:1 Kilogram
FOB Price: $1.0 / 10.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:198904-86-8
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:198904-86-8
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiryProduct name:Des-N-(methoxycarbonyl)-L-tert-leucine Bis-Boc Atazanavir CAS:198904-86-8 Molecular Formula:C32H42N4O5 Molecular Weight:562.69968 EINECS:606-396-7 Purity:99% Appearance:White powder Storage: Room Temperature Package:
Cas:198904-86-8
Min.Order:5 Metric Ton
FOB Price: $1.0 / 2.0
Type:Other
inquiry1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his produccts from many recent effective packing ways;
Cas:198904-86-8
Min.Order:0 Metric Ton
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Type:Trading Company
inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s
Cas:198904-86-8
Min.Order:10 Gram
Negotiable
Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:198904-86-8
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryDes-N-(methoxycarbonyl)-L-tert-leucine Bis-Boc Atazanavir CAS:198904-86-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, sp
Cas:198904-86-8
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:198904-86-8
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:198904-86-8
Min.Order:0
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Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:198904-86-8
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryAppearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Atazanavir Sulfate 1 Transportation:By Sea/Air/Courier Port:Qin
Cas:198904-86-8
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:198904-86-8
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:198904-86-8
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryWe are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
Cas:198904-86-8
Min.Order:100 Gram
FOB Price: $100.0 / 2000.0
Type:Lab/Research institutions
inquiryProduct name: Atazanavir CAS No.: 198904-86-8 Molecule Formula:C32H42N4O5 Molecule Weight:562.70 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard TESTING ITEMS
Cas:198904-86-8
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thinkchem specializes in exp
Des-N-(methoxycarbonyl)-L-tert-leucine Bis-Boc Atazanavir Basic information Product Name: Des-N-(methoxycarbonyl)-L-tert-leucine Bis-Boc Atazanavir Synonyms: 2-[(2S,3S)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-hydroxy-4-phenylbutyl] -2-[[4-(2
Cas:198904-86-8
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:198904-86-8
Min.Order:1 Kilogram
FOB Price: $18.0 / 20.0
Type:Trading Company
inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:198904-86-8
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Cas:198904-86-8
Min.Order:1 Metric Ton
FOB Price: $1.5
Type:Trading Company
inquiryLocated in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h
Cas:198904-86-8
Min.Order:0
Negotiable
Type:Other
inquiry(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
In isopropyl alcohol for 24h; Inert atmosphere; Reflux; Large scale; | 85.4% |
In isopropyl alcohol Heating / reflux; | 75% |
In isopropyl alcohol for 16h; Heating; | 69% |
1-(4-(pyridin-2-yl)-phenyl)-1-oxo-5(S)-2,5-di[(tert-butoxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
With diisobutylaluminium hydride at 0℃; for 2.5h; | 60% |
(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
In isopropyl alcohol at 65℃; for 16h; | 57% |
In isopropyl alcohol at 65 - 85℃; for 16h; Product distribution / selectivity; | 35% |
In isopropyl alcohol at 85℃; for 16h; | 35% |
2-bromo-pyridine
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1.) Mg, I2, 2.) <1,3-bis(diphenylphosphino)propane>nickel(II) chloride, diisobutylaluminum hydride, 3.) aq. HCl 2: 93 percent / ethanol / 4 h / Heating 3: 89 percent / H2 / 10percent Pd/C / methanol 4: 69 percent / propan-2-ol / 16 h / Heating View Scheme | |
Multi-step reaction with 4 steps 1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / toluene; ethanol / 20 h / 76 °C / Inert atmosphere 2: toluene; isopropyl alcohol / 2 h / 80 - 85 °C / Inert atmosphere; Large scale 3: palladium 10% on activated carbon; sodium formate / water; ethanol / 1.5 h / 57 °C 4: isopropyl alcohol / 24 h / Inert atmosphere; Reflux; Large scale View Scheme |
2-(4-formylphenyl)pyridine
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 93 percent / ethanol / 4 h / Heating 2: 89 percent / H2 / 10percent Pd/C / methanol 3: 69 percent / propan-2-ol / 16 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1: toluene; isopropyl alcohol / 2 h / 80 - 85 °C / Inert atmosphere; Large scale 2: palladium 10% on activated carbon; sodium formate / water; ethanol / 1.5 h / 57 °C 3: isopropyl alcohol / 24 h / Inert atmosphere; Reflux; Large scale View Scheme |
1,1-dimethoxy-1-(4-bromophenyl)methane
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1.) Mg, I2, 2.) <1,3-bis(diphenylphosphino)propane>nickel(II) chloride, diisobutylaluminum hydride, 3.) aq. HCl 2: 93 percent / ethanol / 4 h / Heating 3: 89 percent / H2 / 10percent Pd/C / methanol 4: 69 percent / propan-2-ol / 16 h / Heating View Scheme |
N-(tert-butoxycarbonyl)-N'-[4-(pyridin-2-yl)phenylmethylidene]hydrazine
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 89 percent / H2 / 10percent Pd/C / methanol 2: 69 percent / propan-2-ol / 16 h / Heating View Scheme |
t-butoxycarbonylhydrazine
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 53 percent / H2, AcOH / Raney Ni / methanol / 750.06 Torr / Ambient temperature 2: NaBH3CN, TsOH / 1,2-dimethoxy-ethane / Ambient temperature 3: 1.) aq. borax; 2.) MTBD 4: 60 percent / DIBAH / 2.5 h / 0 °C View Scheme |
Boc-L-phenylalaninal
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 39 percent / BnEt3N(1+)*Cl(1-) / H2O; CH2Cl2 / 0 °C 2: 53 percent / H2, AcOH / Raney Ni / methanol / 750.06 Torr / Ambient temperature 3: NaBH3CN, TsOH / 1,2-dimethoxy-ethane / Ambient temperature 4: 1.) aq. borax; 2.) MTBD 5: 60 percent / DIBAH / 2.5 h / 0 °C View Scheme |
4-Pyridin-2-yl-benzoic acid (1R,2S)-2-tert-butoxycarbonylamino-1-(tert-butoxycarbonyl-hydrazonomethyl)-3-phenyl-propyl ester
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: NaBH3CN, TsOH / 1,2-dimethoxy-ethane / Ambient temperature 2: 1.) aq. borax; 2.) MTBD 3: 60 percent / DIBAH / 2.5 h / 0 °C View Scheme |
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1.) aq. borax; 2.) MTBD 2: 60 percent / DIBAH / 2.5 h / 0 °C View Scheme |
4-Pyridin-2-yl-benzoic acid (1R,2S)-2-tert-butoxycarbonylamino-1-cyano-3-phenyl-propyl ester
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 53 percent / H2, AcOH / Raney Ni / methanol / 750.06 Torr / Ambient temperature 2: NaBH3CN, TsOH / 1,2-dimethoxy-ethane / Ambient temperature 3: 1.) aq. borax; 2.) MTBD 4: 60 percent / DIBAH / 2.5 h / 0 °C View Scheme |
(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
A
C47H63N5O9
B
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
In isopropyl alcohol Reflux; |
(2S,3S)-3-(t-butoxycarbonylamino)-4-phenylbutane-1,2-diol
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: dmap; triethylamine / toluene / 3 h / 50 °C / Large scale 1.2: 3 h / 0 - 5 °C / Large scale 2.1: ammonium fluoride; acetic acid / methanol / 11 h / 20 °C / Large scale 3.1: potassium tert-butylate / isopropyl alcohol; tetrahydrofuran / 1.83 h / 17 °C 4.1: isopropyl alcohol / 24 h / Inert atmosphere; Reflux; Large scale View Scheme |
methanesulfonic acid 2-tert-butoxycarbonylamino-1-(tert-butyl-dimethyl-silanyloxymethyl)-3-phenyl-propyl ester
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: ammonium fluoride; acetic acid / methanol / 11 h / 20 °C / Large scale 2: potassium tert-butylate / isopropyl alcohol; tetrahydrofuran / 1.83 h / 17 °C 3: isopropyl alcohol / 24 h / Inert atmosphere; Reflux; Large scale View Scheme |
4-formylphenylboronic acid,
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / toluene; ethanol / 20 h / 76 °C / Inert atmosphere 2: toluene; isopropyl alcohol / 2 h / 80 - 85 °C / Inert atmosphere; Large scale 3: palladium 10% on activated carbon; sodium formate / water; ethanol / 1.5 h / 57 °C 4: isopropyl alcohol / 24 h / Inert atmosphere; Reflux; Large scale View Scheme |
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium tert-butylate / isopropyl alcohol; tetrahydrofuran / 1.83 h / 17 °C 2: isopropyl alcohol / 24 h / Inert atmosphere; Reflux; Large scale View Scheme |
2-[4-(2-pyridinyl)phenyl]methylenehydrazinecarboxylic acid tert-butyl ester
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: palladium 10% on activated carbon; sodium formate / water; ethanol / 1.5 h / 57 °C 2: isopropyl alcohol / 24 h / Inert atmosphere; Reflux; Large scale View Scheme |
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
With hydrogenchloride In tetrahydrofuran at 50℃; for 4h; | 100% |
With hydrogenchloride In tetrahydrofuran at 22 - 55℃; for 3h; Large scale; | 95% |
With hydrogenchloride In dichloromethane at 0 - 40℃; for 1.5h; | |
With hydrogenchloride In dichloromethane; water at 0.5 - 40℃; |
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
1-[4-(pyridin-2-yl)-phenyl]-4(S)-hydroxy-5(S)-2,5-diamino-6-phenyl-2-azahexane hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride; water In tetrahydrofuran at 60℃; for 3h; | 100% |
In 1,4-dioxane; hydrogenchloride; methanol; N,N-dimethyl-formamide; toluene | |
With hydrogenchloride In 1,4-dioxane; dichloromethane at 20℃; for 0.333333h; |
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
1-[4-(pyridin-2-yl)-phenyl]-4(S)-hydroxy-5(S)-2,5-diamino-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
With hydrogenchloride In dichloromethane; water at 40 - 45℃; for 3h; Solvent; Temperature; Concentration; | 96.1% |
Stage #1: 1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane With hydrogenchloride; water In tetrahydrofuran at 60℃; for 3h; Stage #2: With sodium hydrogencarbonate In tetrahydrofuran; water at 25℃; for 3h; | 61% |
Stage #1: 1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane With hydrogenchloride In tetrahydrofuran; water at 60℃; for 3h; Stage #2: With ethanol In tetrahydrofuran; water Stage #3: With sodium hydrogencarbonate In tetrahydrofuran; water at 25℃; for 3h; | 61% |
With hydrogenchloride In 1,4-dioxane at 50℃; for 4h; | |
With hydrogenchloride In dichloromethane |
di-tert-butyl dicarbonate
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Tert-butyl (1S,2S)-1-benzyl-2-hydroxy-3-{1-[4-(2-pyridinyl)benzyl]hydrazino}propylcarbamate
Conditions | Yield |
---|---|
Stage #1: 1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane With hydrogenchloride In tetrahydrofuran; water at 60℃; for 3h; Stage #2: di-tert-butyl dicarbonate With sodium hydrogencarbonate In tetrahydrofuran; water at 25℃; for 3h; | 72% |
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: HCl / dioxane / 4 h / 50 °C 2: Et3N / tetrahydrofuran / 8 h / 0 - 20 °C View Scheme |
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: HCl / dioxane / 4 h / 50 °C 2: Et3N / tetrahydrofuran / 8 h / 0 - 20 °C View Scheme |
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 100 percent / aq. HCl / tetrahydrofuran / 4 h / 50 °C 2: 1.) N-ethyl-N'-<3-(dimethylamino)propyl>carbodiimide hydrochloride, 1-hydroxybenzotriazole, Et3N / 1.) DMF, 0 deg C, 20 min, 2.) DMF, RT, overnight View Scheme |
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
atazanavir
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 100 percent / aq. HCl / tetrahydrofuran / 4 h / 50 °C 2: 1.) O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate, N-ethyldiisopropylamine / 1.) CH2Cl2, 0 deg C, 20 min, 2.) CH2Cl2, overnight View Scheme | |
Multi-step reaction with 2 steps 1: hydrogenchloride / tetrahydrofuran / 3 h / 22 - 55 °C / Large scale 2: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 22 - 25 °C / Large scale View Scheme | |
Multi-step reaction with 2 steps 1: hydrogenchloride / dichloromethane; water / 0.5 - 40 °C 2: dipotassium hydrogenphosphate / water / 5 - 40 °C View Scheme |
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
Stage #1: 1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane With hydrogenchloride In dichloromethane; water at 5 - 40℃; Stage #2: Stage #3: With water for 0.25h; |
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
With hydrogenchloride; water In tetrahydrofuran at 45 - 55℃; for 3h; | |
With hydrogenchloride; water In dichloromethane Reflux; |
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
With trimethylsilyl iodide In tetrahydrofuran |
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydrogenchloride / tetrahydrofuran / 3 h / 22 - 55 °C / Large scale 2: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 22 - 25 °C / Large scale 3: sulfuric acid / ethanol / 22 °C / Large scale View Scheme | |
Multi-step reaction with 3 steps 1: hydrogenchloride / dichloromethane; water / 0.5 - 40 °C 2: dipotassium hydrogenphosphate / water / 5 - 40 °C 3: sulfuric acid / acetone; 1-methyl-pyrrolidin-2-one / 0.5 h / 40 - 50 °C View Scheme |
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