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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Des-N-(methoxycarbonyl)-L-tert-leucine Bis-Boc Atazanavir supplier in China

Cas:198904-86-8

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of Des-N-(methoxycarbonyl)-L-tert-leucine Bis-Boc Atazanavir Cas 198904-86-8 Guaranteed purity High quality & competitive price Quality control Fast feedback Appearance:White powder Storage:cool dry place Package:100g/1kg/fo

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/1488.html Product Name 2-[(2S,3S)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-hydroxy -4-phenylbu

Henan Tianfu Chemical Co., Ltd.

Des-N-(methoxycarbonyl)-L-tert-leucine Bis-Boc Atazanavir Basic information Product Name: Des-N-(methoxycarbonyl)-L-tert-leucine Bis-Boc Atazanavir Synony

198904-86-8 Des-N-(methoxycarbonyl)-L-tert-leucine Bis-Boc Atazanavir

Cas:198904-86-8

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu

Des-N- (methoxycarbonyl) -L-Tert-Leucine Bis-Boc Atazanavir CAS198904-86-8

Cas:198904-86-8

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 198904-86-8 with competitive price

Cas:198904-86-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Henan Sinotech Import&Export Corporation

Product name:Des-N-(methoxycarbonyl)-L-tert-leucine Bis-Boc Atazanavir CAS:198904-86-8 Molecular Formula:C32H42N4O5 Molecular Weight:562.69968 EINECS:606-396-7 Purity:99% Appearance:White powder Storage: Room Temperature Package:

Des-N-(methoxycarbonyl)-L-tert-leucine Bis-Boc Atazanavir CAS: 198904-86-8

Cas:198904-86-8

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Shijiazhuang Sdyano Fine Chemical Co., Ltd

1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his produccts from many recent effective packing ways;

Des-N-(methoxycarbonyl)-L-tert-leucine Bis-Boc Atazanavir

Cas:198904-86-8

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Qingdao Beluga Import and Export Co., LTD

Des-N-(methoxycarbonyl)-L-tert-leucine Bis-Boc Atazanavir CAS:198904-86-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, sp

Des-N-(methoxycarbonyl)-L-tert-leucine Bis-Boc Atazanavir CAS:198904-86-8

Cas:198904-86-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1-[4-(Pyridin-2-yl)phenyl]-5-(s)-2,5-bis[(tert-butyloxycarbonyl)-amino]-4(s)-hydroxyl-6-phenyl-2-azahexane

Cas:198904-86-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Atazanavir Sulfate 1 Transportation:By Sea/Air/Courier Port:Qin

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

198904-86-8

Cas:198904-86-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Des-N-(methoxycarbonyl)-L-tert-leucine Bis-Boc Atazanavir

Cas:198904-86-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

Siwei Development Group Ltd.

Product name: Atazanavir CAS No.: 198904-86-8 Molecule Formula:C32H42N4O5 Molecule Weight:562.70 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard TESTING ITEMS

Lower Price Atazanavir in stock

Cas:198904-86-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Think Chemical Co. Ltd

HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thinkchem specializes in exp

Atazanavir intermediates 198904-86-8

Cas:198904-86-8

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Shanghai Minstar Chemical Co., Ltd

Des-N-(methoxycarbonyl)-L-tert-leucine Bis-Boc Atazanavir Basic information Product Name: Des-N-(methoxycarbonyl)-L-tert-leucine Bis-Boc Atazanavir Synonyms: 2-[(2S,3S)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-hydroxy-4-phenylbutyl] -2-[[4-(2

Des-N-(methoxycarbonyl)-L-tert-leucine Bis-Boc Atazanavir

Cas:198904-86-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

Synthetic route

(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane
98760-08-8

(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
198904-85-7

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
198904-86-8

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

Conditions
ConditionsYield
In isopropyl alcohol for 24h; Inert atmosphere; Reflux; Large scale;85.4%
In isopropyl alcohol Heating / reflux;75%
In isopropyl alcohol for 16h; Heating;69%
1-(4-(pyridin-2-yl)-phenyl)-1-oxo-5(S)-2,5-di[(tert-butoxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
198905-10-1

1-(4-(pyridin-2-yl)-phenyl)-1-oxo-5(S)-2,5-di[(tert-butoxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
198904-86-8

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

Conditions
ConditionsYield
With diisobutylaluminium hydride at 0℃; for 2.5h;60%
(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester
98760-08-8, 98818-34-9, 98818-35-0, 103127-56-6, 98737-29-2

(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
198904-85-7

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
198904-86-8

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

Conditions
ConditionsYield
In isopropyl alcohol at 65℃; for 16h;57%
In isopropyl alcohol at 65 - 85℃; for 16h; Product distribution / selectivity;35%
In isopropyl alcohol at 85℃; for 16h;35%
2-bromo-pyridine
109-04-6

2-bromo-pyridine

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
198904-86-8

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) Mg, I2, 2.) <1,3-bis(diphenylphosphino)propane>nickel(II) chloride, diisobutylaluminum hydride, 3.) aq. HCl
2: 93 percent / ethanol / 4 h / Heating
3: 89 percent / H2 / 10percent Pd/C / methanol
4: 69 percent / propan-2-ol / 16 h / Heating
View Scheme
Multi-step reaction with 4 steps
1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / toluene; ethanol / 20 h / 76 °C / Inert atmosphere
2: toluene; isopropyl alcohol / 2 h / 80 - 85 °C / Inert atmosphere; Large scale
3: palladium 10% on activated carbon; sodium formate / water; ethanol / 1.5 h / 57 °C
4: isopropyl alcohol / 24 h / Inert atmosphere; Reflux; Large scale
View Scheme
2-(4-formylphenyl)pyridine
127406-56-8

2-(4-formylphenyl)pyridine

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
198904-86-8

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 93 percent / ethanol / 4 h / Heating
2: 89 percent / H2 / 10percent Pd/C / methanol
3: 69 percent / propan-2-ol / 16 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: toluene; isopropyl alcohol / 2 h / 80 - 85 °C / Inert atmosphere; Large scale
2: palladium 10% on activated carbon; sodium formate / water; ethanol / 1.5 h / 57 °C
3: isopropyl alcohol / 24 h / Inert atmosphere; Reflux; Large scale
View Scheme
1,1-dimethoxy-1-(4-bromophenyl)methane
24856-58-4

1,1-dimethoxy-1-(4-bromophenyl)methane

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
198904-86-8

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) Mg, I2, 2.) <1,3-bis(diphenylphosphino)propane>nickel(II) chloride, diisobutylaluminum hydride, 3.) aq. HCl
2: 93 percent / ethanol / 4 h / Heating
3: 89 percent / H2 / 10percent Pd/C / methanol
4: 69 percent / propan-2-ol / 16 h / Heating
View Scheme
N-(tert-butoxycarbonyl)-N'-[4-(pyridin-2-yl)phenylmethylidene]hydrazine
857904-11-1

N-(tert-butoxycarbonyl)-N'-[4-(pyridin-2-yl)phenylmethylidene]hydrazine

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
198904-86-8

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 89 percent / H2 / 10percent Pd/C / methanol
2: 69 percent / propan-2-ol / 16 h / Heating
View Scheme
t-butoxycarbonylhydrazine
870-46-2

t-butoxycarbonylhydrazine

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
198904-86-8

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 53 percent / H2, AcOH / Raney Ni / methanol / 750.06 Torr / Ambient temperature
2: NaBH3CN, TsOH / 1,2-dimethoxy-ethane / Ambient temperature
3: 1.) aq. borax; 2.) MTBD
4: 60 percent / DIBAH / 2.5 h / 0 °C
View Scheme
Boc-L-phenylalaninal
72155-45-4

Boc-L-phenylalaninal

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
198904-86-8

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 39 percent / BnEt3N(1+)*Cl(1-) / H2O; CH2Cl2 / 0 °C
2: 53 percent / H2, AcOH / Raney Ni / methanol / 750.06 Torr / Ambient temperature
3: NaBH3CN, TsOH / 1,2-dimethoxy-ethane / Ambient temperature
4: 1.) aq. borax; 2.) MTBD
5: 60 percent / DIBAH / 2.5 h / 0 °C
View Scheme
4-Pyridin-2-yl-benzoic acid (1R,2S)-2-tert-butoxycarbonylamino-1-(tert-butoxycarbonyl-hydrazonomethyl)-3-phenyl-propyl ester
198905-09-8

4-Pyridin-2-yl-benzoic acid (1R,2S)-2-tert-butoxycarbonylamino-1-(tert-butoxycarbonyl-hydrazonomethyl)-3-phenyl-propyl ester

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
198904-86-8

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: NaBH3CN, TsOH / 1,2-dimethoxy-ethane / Ambient temperature
2: 1.) aq. borax; 2.) MTBD
3: 60 percent / DIBAH / 2.5 h / 0 °C
View Scheme
4-Pyridin-2-yl-benzoic acid (1S,2S)-2-tert-butoxycarbonylamino-1-(N'-tert-butoxycarbonyl-hydrazinomethyl)-3-phenyl-propyl ester

4-Pyridin-2-yl-benzoic acid (1S,2S)-2-tert-butoxycarbonylamino-1-(N'-tert-butoxycarbonyl-hydrazinomethyl)-3-phenyl-propyl ester

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
198904-86-8

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) aq. borax; 2.) MTBD
2: 60 percent / DIBAH / 2.5 h / 0 °C
View Scheme
4-Pyridin-2-yl-benzoic acid (1R,2S)-2-tert-butoxycarbonylamino-1-cyano-3-phenyl-propyl ester
198905-08-7

4-Pyridin-2-yl-benzoic acid (1R,2S)-2-tert-butoxycarbonylamino-1-cyano-3-phenyl-propyl ester

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
198904-86-8

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 53 percent / H2, AcOH / Raney Ni / methanol / 750.06 Torr / Ambient temperature
2: NaBH3CN, TsOH / 1,2-dimethoxy-ethane / Ambient temperature
3: 1.) aq. borax; 2.) MTBD
4: 60 percent / DIBAH / 2.5 h / 0 °C
View Scheme
(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane
98760-08-8

(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
198904-85-7

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine

A

C47H63N5O9
1140968-73-5

C47H63N5O9

B

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
198904-86-8

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

Conditions
ConditionsYield
In isopropyl alcohol Reflux;
(2S,3S)-3-(t-butoxycarbonylamino)-4-phenylbutane-1,2-diol
149451-80-9

(2S,3S)-3-(t-butoxycarbonylamino)-4-phenylbutane-1,2-diol

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
198904-86-8

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: dmap; triethylamine / toluene / 3 h / 50 °C / Large scale
1.2: 3 h / 0 - 5 °C / Large scale
2.1: ammonium fluoride; acetic acid / methanol / 11 h / 20 °C / Large scale
3.1: potassium tert-butylate / isopropyl alcohol; tetrahydrofuran / 1.83 h / 17 °C
4.1: isopropyl alcohol / 24 h / Inert atmosphere; Reflux; Large scale
View Scheme
methanesulfonic acid 2-tert-butoxycarbonylamino-1-(tert-butyl-dimethyl-silanyloxymethyl)-3-phenyl-propyl ester
437713-03-6

methanesulfonic acid 2-tert-butoxycarbonylamino-1-(tert-butyl-dimethyl-silanyloxymethyl)-3-phenyl-propyl ester

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
198904-86-8

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: ammonium fluoride; acetic acid / methanol / 11 h / 20 °C / Large scale
2: potassium tert-butylate / isopropyl alcohol; tetrahydrofuran / 1.83 h / 17 °C
3: isopropyl alcohol / 24 h / Inert atmosphere; Reflux; Large scale
View Scheme
4-formylphenylboronic acid,
87199-17-5

4-formylphenylboronic acid,

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
198904-86-8

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / toluene; ethanol / 20 h / 76 °C / Inert atmosphere
2: toluene; isopropyl alcohol / 2 h / 80 - 85 °C / Inert atmosphere; Large scale
3: palladium 10% on activated carbon; sodium formate / water; ethanol / 1.5 h / 57 °C
4: isopropyl alcohol / 24 h / Inert atmosphere; Reflux; Large scale
View Scheme
C16H25NO6S

C16H25NO6S

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
198904-86-8

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium tert-butylate / isopropyl alcohol; tetrahydrofuran / 1.83 h / 17 °C
2: isopropyl alcohol / 24 h / Inert atmosphere; Reflux; Large scale
View Scheme
2-[4-(2-pyridinyl)phenyl]methylenehydrazinecarboxylic acid tert-butyl ester
198904-84-6

2-[4-(2-pyridinyl)phenyl]methylenehydrazinecarboxylic acid tert-butyl ester

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
198904-86-8

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: palladium 10% on activated carbon; sodium formate / water; ethanol / 1.5 h / 57 °C
2: isopropyl alcohol / 24 h / Inert atmosphere; Reflux; Large scale
View Scheme
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
198904-86-8

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

1-[4-(pyridin-2-yl)phenyl]-4(S)-hydroxy-5(S)-2,5-diamino-6-phenyl-2-azahexane trihydrochloride

1-[4-(pyridin-2-yl)phenyl]-4(S)-hydroxy-5(S)-2,5-diamino-6-phenyl-2-azahexane trihydrochloride

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran at 50℃; for 4h;100%
With hydrogenchloride In tetrahydrofuran at 22 - 55℃; for 3h; Large scale;95%
With hydrogenchloride In dichloromethane at 0 - 40℃; for 1.5h;
With hydrogenchloride In dichloromethane; water at 0.5 - 40℃;
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
198904-86-8

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

1-[4-(pyridin-2-yl)-phenyl]-4(S)-hydroxy-5(S)-2,5-diamino-6-phenyl-2-azahexane hydrochloride
1313358-78-9

1-[4-(pyridin-2-yl)-phenyl]-4(S)-hydroxy-5(S)-2,5-diamino-6-phenyl-2-azahexane hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; water In tetrahydrofuran at 60℃; for 3h;100%
In 1,4-dioxane; hydrogenchloride; methanol; N,N-dimethyl-formamide; toluene
With hydrogenchloride In 1,4-dioxane; dichloromethane at 20℃; for 0.333333h;
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
198904-86-8

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

1-[4-(pyridin-2-yl)-phenyl]-4(S)-hydroxy-5(S)-2,5-diamino-6-phenyl-2-azahexane
437713-06-9

1-[4-(pyridin-2-yl)-phenyl]-4(S)-hydroxy-5(S)-2,5-diamino-6-phenyl-2-azahexane

Conditions
ConditionsYield
With hydrogenchloride In dichloromethane; water at 40 - 45℃; for 3h; Solvent; Temperature; Concentration;96.1%
Stage #1: 1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane With hydrogenchloride; water In tetrahydrofuran at 60℃; for 3h;
Stage #2: With sodium hydrogencarbonate In tetrahydrofuran; water at 25℃; for 3h;
61%
Stage #1: 1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane With hydrogenchloride In tetrahydrofuran; water at 60℃; for 3h;
Stage #2: With ethanol In tetrahydrofuran; water
Stage #3: With sodium hydrogencarbonate In tetrahydrofuran; water at 25℃; for 3h;
61%
With hydrogenchloride In 1,4-dioxane at 50℃; for 4h;
With hydrogenchloride In dichloromethane
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
198904-86-8

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

Tert-butyl (1S,2S)-1-benzyl-2-hydroxy-3-{1-[4-(2-pyridinyl)benzyl]hydrazino}propylcarbamate
857904-20-2

Tert-butyl (1S,2S)-1-benzyl-2-hydroxy-3-{1-[4-(2-pyridinyl)benzyl]hydrazino}propylcarbamate

Conditions
ConditionsYield
Stage #1: 1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane With hydrogenchloride In tetrahydrofuran; water at 60℃; for 3h;
Stage #2: di-tert-butyl dicarbonate With sodium hydrogencarbonate In tetrahydrofuran; water at 25℃; for 3h;
72%
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
198904-86-8

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

C42H40N6O7

C42H40N6O7

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: HCl / dioxane / 4 h / 50 °C
2: Et3N / tetrahydrofuran / 8 h / 0 - 20 °C
View Scheme
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
198904-86-8

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

C46H44N6O9

C46H44N6O9

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: HCl / dioxane / 4 h / 50 °C
2: Et3N / tetrahydrofuran / 8 h / 0 - 20 °C
View Scheme
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
198904-86-8

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

1-[4-(Pyridin-2-yl)-phenyl]-4(S)-hydroxy-5(S)-2,5-bis[N-(N-methoxycarbonyl-(L)-valyl)amino]-6-phenyl-2-azahexane

1-[4-(Pyridin-2-yl)-phenyl]-4(S)-hydroxy-5(S)-2,5-bis[N-(N-methoxycarbonyl-(L)-valyl)amino]-6-phenyl-2-azahexane

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 100 percent / aq. HCl / tetrahydrofuran / 4 h / 50 °C
2: 1.) N-ethyl-N'-<3-(dimethylamino)propyl>carbodiimide hydrochloride, 1-hydroxybenzotriazole, Et3N / 1.) DMF, 0 deg C, 20 min, 2.) DMF, RT, overnight
View Scheme
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
198904-86-8

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

atazanavir
198904-31-3

atazanavir

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 100 percent / aq. HCl / tetrahydrofuran / 4 h / 50 °C
2: 1.) O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate, N-ethyldiisopropylamine / 1.) CH2Cl2, 0 deg C, 20 min, 2.) CH2Cl2, overnight
View Scheme
Multi-step reaction with 2 steps
1: hydrogenchloride / tetrahydrofuran / 3 h / 22 - 55 °C / Large scale
2: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 22 - 25 °C / Large scale
View Scheme
Multi-step reaction with 2 steps
1: hydrogenchloride / dichloromethane; water / 0.5 - 40 °C
2: dipotassium hydrogenphosphate / water / 5 - 40 °C
View Scheme
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
198904-86-8

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

1-[4-(Pyridin-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane.3hydrochloride

1-[4-(Pyridin-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane.3hydrochloride

Conditions
ConditionsYield
Stage #1: 1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane With hydrogenchloride In dichloromethane; water at 5 - 40℃;
Stage #2:
Stage #3: With water for 0.25h;
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
198904-86-8

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

(2S,3S)-3-amino-4-phenyl-1-(1-(4-(pyridin-2-yl)benzyl)hydrazinyl)butan-2-ol hydrochloride

(2S,3S)-3-amino-4-phenyl-1-(1-(4-(pyridin-2-yl)benzyl)hydrazinyl)butan-2-ol hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; water In tetrahydrofuran at 45 - 55℃; for 3h;
With hydrogenchloride; water In dichloromethane Reflux;
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
198904-86-8

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

C22H26N4O*3HI

C22H26N4O*3HI

Conditions
ConditionsYield
With trimethylsilyl iodide In tetrahydrofuran
1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
198904-86-8

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

atazanavir sulphate

atazanavir sulphate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride / tetrahydrofuran / 3 h / 22 - 55 °C / Large scale
2: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 22 - 25 °C / Large scale
3: sulfuric acid / ethanol / 22 °C / Large scale
View Scheme
Multi-step reaction with 3 steps
1: hydrogenchloride / dichloromethane; water / 0.5 - 40 °C
2: dipotassium hydrogenphosphate / water / 5 - 40 °C
3: sulfuric acid / acetone; 1-methyl-pyrrolidin-2-one / 0.5 h / 40 - 50 °C
View Scheme

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